CN103768643B - A kind of silver ion alginate sustained-release antibacterial gel and preparation method thereof - Google Patents
A kind of silver ion alginate sustained-release antibacterial gel and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of medicine, be specifically related to a kind of silver ion alginate sustained-release antibacterial gel and preparation method thereof.Silver ion alginate sustained-release antibacterial gel effective ingredient of the present invention is silver ion, gel-type vehicle is alginate, and silver ion content is 0.001% to 10%, and the release time of silver ion continues more than 50 hours, silver ion releasing ratio, more than 70%, has good slow release effect.Silver ion alginate sustained-release antibacterial gel process for preparing of the present invention, is loaded in silver ion richness in high-ratio surface porous carrier, more effectively can avoids the oxidation of silver ion; The porous carrier being rich in silver ion evenly spreads in alginate solution and forms gel, ensure that uniformity and the antibacterial effect of preparation; Preparation method is simple, is easy to industrialization.
Description
Technical field
The invention belongs to technical field of medicine, be specifically related to a kind of silver ion alginate sustained-release antibacterial gel and preparation method thereof.
Technical background
Have research to think, wound will heal soon than under the environment of drying under moistening environment, makes the process of people to wound healing have new understanding.Bacteriological infection is one of principal element affecting wound healing, and a large amount of inflammatory factors, protease and the free radical that contain in wound fluid all can slow down the healing rate of wound.The research and development of NEW TYPE OF COMPOSITE biological antibiosis agent have important meaning to treatment surgical infection wound, are the inexorable trends of wound dressing development.
With alginate be raw material research and development alginate fibre has avirulence, height absorbs water into gelation, high oxygen permeability, good biocompatibility, overall ease of removal, good biodegradation absorbability, anthemorrhagic performance, can promote the advantageous characteristic such as wound healing, macroion adsorptivity, be widely used in biomedical research.Alginic acid is as Absorbable hemostatic material, and it has inhibitory action to bacterial growth.Alginic acid biological dressing extracts from natural seaweed, and the material used in the course of processing is without any toxicity, and thus alginic acid fibre biological dressing is to human non-toxic.
Silver and compound thereof are widely applied in the field such as medical science, health with its excellent antibacterial and bacteriostasis property.Silver ion is used as anti-biotic material because the advantages such as its antibacterial ability is strong are selected and has long history, silver ion is considered to have the antibacterial activity of wide spectrum, all there is antibacterial action to gram-negative bacteria, gram positive bacteria, fungus and fractionated viral etc., even very strong antibacterial action is all demonstrated to some Resistant strains.Carrying silver ion dressing goes out for antibacterial, antibacterial silver ion or atom because of its sustained release, thus avoids wound infection.
At present, in alginic acid fibre, add chemical reaction method and the mixing method of silver ion.Chemical method refers to and to be prepared from sodium ion in Ag ion exchange alginate.But because silver ion is monovalent metallic ion, when sodium alginate aqueous solution adds after silver nitrate aqueous solution exchanges, sodium alginate is also unlike in when adding calcium chloride water and can forms gel like that.And have very strong oxidisability due to silver ion, be easy to blackening after light met by antibacterial prepared by this method, have impact on the outward appearance of product.Mixing method refers to and directly the inorganic salt nano particles of argentiferous and alginate is mixed with solid antimicrobial, but uneven owing to mixing the dispersion in the mixture of rear silver, affects antibacterial effect.After this solid antimicrobial is made gel still can there is the problem of oxidation in silver ion.
Although antibacterial prepared by said method has certain effect, still there is obvious shortcoming.And the antibacterial of preparation does not all have the effect of slow release silver ion.
Summary of the invention
The present invention aims to provide a kind of silver ion alginate antibacterial gel with slow-release function.Effective ingredient is silver ion, and gel-type vehicle is alginate, and silver ion content is 0.001% to 10%, and the release time of silver ion continues more than 50 hours, and silver ion releasing ratio is more than 70%.
The present invention also aims to provide a kind of preparation method with the silver ion alginate antibacterial gel of slow-release function.The porous carrier of rich carrying silver ion is evenly spread in alginate solution, then adds high-valence cationic and obtain gel.
First preparation is rich in the porosu solid of the high-specific surface area of silver ion as the carrier of slow release silver ion, is then prepared into gel with alginate.The porosu solid being rich in the high-specific surface area of silver ion just as " storage silver ion pond ", can discharge silver ion slowly, reach the effect of slow release silver ion in gel in alginate.
Particularly, the inventive method comprises the following steps:
The porous carrier of silver ion is rich in a, preparation;
B, prepare alginate solution;
C, the porous carrier being rich in silver ion in a is joined in b in alginate solution, dispersed;
D, in dispersion liquid in c, add high-valence cationic solution, form gel.
More specifically, the inventive method comprises the following steps:
A, utilize the zeolite molecular sieve with ion exchanging function of high-specific surface area and silver ion solution to carry out ion exchange, the porous carrier of silver ion is rich in preparation;
B, prepare alginate solution;
C, the porous carrier being rich in silver ion in a is joined in b in alginate solution, dispersed;
D, in dispersion liquid in c, add high-valence cationic solution, stir, leave standstill and form gel.
Preferably, being rich in silver ion content in the porous carrier of silver ion is 5% ~ 75%.
Preferably, alginate solution concentration is 1% ~ 50%, and alginate comprises sodium alginate and/or potassium alginate.
Preferably, porous carrier select high-specific surface area there is ion exchanging function porous carrier, comprise type A zeolite molecular sieve, X-type zeolite molecular sieve, Y-type zeolite molecular sieve, natural mordenite molecular sieve, natural clinoptilolite molecular sieve, synthesizing Si-Al zeolite molecular sieve, aluminium phosphate molecular sieve, mesopore molecular sieve or brucite.
Preferably, type A zeolite molecular sieve comprises NaA, KA, CaA, and described X-type zeolite molecular sieve comprises NaX, LiX, HX, CaX, and described Y-type zeolite molecular sieve comprises MgY, NaY, CaY, HY.
Preferably, the molecular composition of Si-Al zeolite molecular sieve of described type A zeolite molecular sieve, X-type zeolite molecular sieve, Y-type zeolite molecular sieve, natural clinoptilolite molecular sieve, natural mordenite molecular sieve (MOR) and synthesis is 0.5 ~ 15molNa
2o, 0.5 ~ 14molSiO
2, 0.5 ~ 10molAl
2o
3, 0.1 ~ 20molH
2o; Described aluminium phosphate molecular sieve molecular composition is 0.5 ~ 10molNa
2o, 0.5 ~ 14molP
2o
5, 0.5 ~ 10molAl
2o
3, 0.1 ~ 30molH
2o; Described mesopore molecular sieve consists of 0.5 ~ 14molSiO
2, 0.1 ~ 30molH
2o.
Silver ion solution is preferably silver nitrate or silver acetate solutions, and ion-exchange temperature is that room temperature (20 DEG C) is to 80 DEG C.
Preferably, the addition of porous carrier in alginate solution being rich in silver ion described in is 0.01% ~ 20%.
Preferably, described high-valence cationic comprises Ca
2+, Zn
2+, Mn
2+, Fe
2+, Fe
3+, Al
3+, Co
2+and/or Cu
2+; High-valence cationic concentration is 0.5%-85%, and addition is 1% ~ 50%, and one-tenth gelling temp is that room temperature (20 DEG C) is to 80 DEG C; High-valence cationic is present in aqueous solution with soluble-salt form, as being the aqueous solution of acetate, nitrate, sulfate or chloride etc.
Silver ion alginate sustained-release antibacterial gel of the present invention, there is good slow release effect, the release time of silver ion can continue more than 50 hours, and extend a lot than common silver-ion antibiotic preparation silver ion release duration, the releasing ratio of silver ion has exceeded 70%.
Silver ion alginate sustained-release antibacterial gel process for preparing of the present invention, is loaded in silver ion richness in high-ratio surface porous carrier, more effectively can avoids the oxidation of silver ion; The porous carrier being rich in silver ion evenly spreads in alginate solution and forms gel, ensure that uniformity and the antibacterial effect of preparation; Preparation method is simple, is easy to industrialization.
Accompanying drawing explanation
Fig. 1: embodiment 1 silver ion alginate sustained-release antibacterial gel and the releasing effect comparison diagram of alginate silver ion directly adding silver ion
Fig. 2: the releasing effect figure of embodiment 2 silver ion alginate sustained-release antibacterial gel silver ion
Fig. 3: the releasing effect figure of embodiment 6 silver ion alginate sustained-release antibacterial gel silver ion
Fig. 4: the releasing effect figure of embodiment 8 silver ion alginate sustained-release antibacterial gel silver ion
Detailed description of the invention
The present invention is further elaborated in conjunction with respective drawings to adopt specific embodiment below.
Embodiment 1
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver nitrate solution 100 milliliters of 50%, what take 25g oven dry consists of 0.5 ~ 5molNa
2o:0.5 ~ 10molSiO
2: 0.5 ~ 10molAl
2o
3: 0.1 ~ 100molH
2the NaA zeolite of O, 60 DEG C exchange 3 hours, sucking filtration, dry.Repeat above-mentioned steps three times, the obtained NaA type porous carrier being rich in silver ion.Ag exists in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 75%.
The preparation of alginate solution: solution sodium alginate distilled water being mixed with 5% concentration, and be placed in 60 DEG C of waters bath with thermostatic control, make it dissolve completely.Take the NaA carrier 20g being rich in Ag ion, join in the sodium alginate soln of the above-mentioned concentration of 100mL, continue stirring 2 hours.
The preparation of gel: joined in the sodium alginate soln of argentiferous carrier of above-mentioned concentration by 50% volume ratio by the ferric chloride solution of 20%, forms gel under being allowed to condition at 60 DEG C of conditions.The content of the gel silver ion of final preparation is 10%.
Silver ion slow release effect is measured: take a certain amount of silver gel that contains and load in bag filter (molecular cut off is 2000), then bag filter is put into deionized water, the amount measuring silver ion in different time deionized water judges the slow-release capability of gel.
The present embodiment is prepared into the slow release effect of silver ion alginate sustained-release antibacterial gel, contrasts, as shown in Figure 1 with the releasing effect of the alginate silver ion directly adding silver ion.Can obviously find out from figure, the present embodiment is prepared into silver ion alginate sustained-release antibacterial gel, the release time of silver ion can continue 90 hours, and extend a lot than the alginate silver ion release duration directly adding silver ion, the releasing ratio of silver ion has exceeded 90%.
Embodiment 2
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver acetate solutions 100 milliliters of 20%, what take 25g oven dry consists of 0.5 ~ 5molNa
2o:0.5 ~ 10molSiO
2: 0.5 ~ 10molAl
2o
3: 0.1 ~ 100molH
2the NaX zeolite of O, 30 DEG C exchange 2 hours, sucking filtration, dry.Repeat above-mentioned steps three times, the obtained NaX type porous carrier being rich in silver ion.Ag exists in the carrier in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 5%.
The preparation of alginate solution: solution potassium alginate distilled water being mixed with 1% concentration, takes the NaX carrier 100mg being rich in Ag ion, joins in the sodium alginate soln of the above-mentioned concentration of 100mL, continues stirring 2 hours.
The preparation of gel: by the aluminum sulfate solution of 0.5% in 1% ratio pour in the potassium alginate solution of the argentiferous carrier of above-mentioned concentration, form gel under being allowed to condition at 50 DEG C of conditions.The content of the gel silver ion of final preparation is 0.005%.
Silver ion slow release effect is measured: as shown in Figure 2, embodiment 2 is prepared into silver ion alginate sustained-release antibacterial gel, and the release time of silver ion can continue more than 90 hours, and the releasing ratio of silver ion has exceeded 75%.
Embodiment 3
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver acetate solutions 100 milliliters of 30%, what take 25g oven dry consists of 0.5 ~ 5molNa
2o:0.5 ~ 10molSiO
2: 0.5 ~ 10molAl
2o
3: 0.1 ~ 100molH
2the MgY zeolite of O, 50 DEG C exchange 2 hours, sucking filtration, dry.Repeat above-mentioned steps three times, the obtained MgY type porous carrier being rich in silver ion.Ag exists in the carrier in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 40%.
The preparation of alginate solution: solution potassium alginate distilled water being mixed with 3% concentration, takes the MgY carrier 10g being rich in Ag ion, joins in the sodium alginate soln of the above-mentioned concentration of 100mL, continues stirring 2 hours.
The preparation of gel: by the zinc nitrate solution of 85% in 30% ratio pour in the sodium alginate soln of argentiferous carrier of above-mentioned concentration, form gel under being allowed to condition at 40 DEG C of conditions.The content of the gel silver ion of final preparation is 3%.
Silver ion slow release effect is measured: as shown in Figure 3, embodiment 3 is prepared into silver ion alginate sustained-release antibacterial gel, and the release time of silver ion can continue more than 60 hours, and the releasing ratio of silver ion has exceeded 80%.
Embodiment 4
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver nitrate solution 100 milliliters of 50%, what take 25g oven dry consists of 0.5 ~ 5molNa
2o:0.5 ~ 10molSiO
2: 0.5 ~ 10molAl
2o
3: 0.1 ~ 100molH
2the natural mordenite of O, 70 DEG C exchange 2 hours, sucking filtration, dry.Repeat above-mentioned steps three times, the obtained natural mordenite porous carrier being rich in silver ion.Ag exists in the carrier in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 30%.
The preparation of alginate solution: solution sodium alginate distilled water being mixed with 5% concentration, takes the natural mordenite carrier 500mg being rich in Ag ion, joins in the sodium alginate soln of the above-mentioned concentration of 100mL, continues stirring 2 hours.
The preparation of gel: by the copper-bath of 1% in 40% ratio pour in the sodium alginate soln of argentiferous carrier of above-mentioned concentration, form gel under being allowed to condition at 80 DEG C of conditions.The content of the gel silver ion of final preparation is 0.1%.
Silver ion slow release effect is measured: as shown in Figure 4, embodiment 4 is prepared into silver ion alginate sustained-release antibacterial gel, and the release time of silver ion can continue more than 80 hours, and the releasing ratio of silver ion has exceeded 85%.
Embodiment 5
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver nitrate solution 100 milliliters of 30%, what take 25g oven dry consists of 0.5 ~ 5molNa
2o:0.5 ~ 10molSiO
2: 0.5 ~ 10molAl
2o
3: 0.1 ~ 100molH
2the natural clinoptilolite molecular sieve of O, 30 DEG C exchange 2 hours, sucking filtration, dry.Repeat above-mentioned steps three times, the obtained natural clinoptilolite molecular sieve porous carrier being rich in silver ion.Ag exists in the carrier in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 20%.
The preparation of alginate solution: solution sodium alginate distilled water being mixed with 3% concentration, takes the natural clinoptilolite molecular sieve porous carrier 2.5g being rich in Ag ion, joins in the sodium alginate soln of the above-mentioned concentration of 100mL, continues stirring 2 hours.
The preparation of gel: by violent for the nitric acid of 30% solution in 2% ratio pour in the sodium alginate soln of argentiferous carrier of above-mentioned concentration, form gel under being allowed to condition at 20 DEG C of conditions.The content of the gel silver ion of final preparation is 0.5%.
Silver ion slow release effect is measured: embodiment 5 is prepared into silver ion alginate sustained-release antibacterial gel, and the release time of silver ion can continue more than 65 hours, and the releasing ratio of silver ion has exceeded 85%.
Embodiment 6
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver acetate solutions 100 milliliters of 50%, what take 25g oven dry consists of 0.5 ~ 5molNa
2o:0.5 ~ 10molSiO
2: 0.5 ~ 10molAl
2o
3: 0.1 ~ 100molH
2the synthesizing Si-Al zeolite molecular sieve of O, 40 DEG C exchange 1 hour, sucking filtration, dry.Repeat above-mentioned steps three times, the obtained synthesizing Si-Al zeolite molecular sieve porous carrier being rich in silver ion.Ag exists in the carrier in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 10%.
The preparation of alginate solution: solution sodium alginate distilled water being mixed with 5% concentration, takes the synthesizing Si-Al zeolite molecular sieve porous carrier 10mg being rich in Ag ion, joins in the sodium alginate soln of the above-mentioned concentration of 100mL, continues stirring 2 hours.
The preparation of gel: by the calcium chloride solution of 50% in 10% ratio pour in the sodium alginate soln of argentiferous carrier of above-mentioned concentration, form gel under being allowed to condition at 30 DEG C of conditions.The content of the gel silver ion of final preparation is 0.001%.
Silver ion slow release effect is measured: embodiment 6 is prepared into silver ion alginate sustained-release antibacterial gel, and the release time of silver ion can continue more than 70 hours, and the releasing ratio of silver ion has exceeded 85%.
Embodiment 7
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver nitrate solution 100 milliliters of 50%, what take 25g oven dry consists of 0.5 ~ 10molNa
2o, 0.5 ~ 14molP
2o
5, 0.5 ~ 10molAl
2o
3, 0.1 ~ 30molH
2the aluminium phosphate molecular sieve of O, 80 DEG C exchange 2 hours, sucking filtration, dry.Repeat above-mentioned steps three times, the obtained aluminium phosphate molecular sieve porous carrier being rich in silver ion.Ag exists in the carrier in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 50%.
The preparation of alginate solution: solution potassium alginate distilled water being mixed with 4% concentration, takes the aluminium phosphate molecular sieve porous carrier 6g being rich in Ag ion, joins in the sodium alginate soln of the above-mentioned concentration of 100mL, continues stirring 2 hours.
The preparation of gel: by the copperas solution of 10% in 20% ratio pour in the sodium alginate soln of argentiferous carrier of above-mentioned concentration, form gel under being allowed to condition at 70 DEG C of conditions.The content of the gel silver ion of final preparation is 2.5%.
Silver ion slow release effect is measured: embodiment 7 is prepared into silver ion alginate sustained-release antibacterial gel, and the release time of silver ion can continue more than 50 hours, and the releasing ratio of silver ion has exceeded 75%.
Embodiment 8
Be rich in the preparation of the porous carrier of silver ion: configuration concentration is the silver nitrate solution 100 milliliters of 50%, what take 25g oven dry consists of 0.5 ~ 10molNa
2o, 0.5 ~ 14molP
2o
5, 0.5 ~ 10molAl
2o
3, 0.1 ~ 30molH
2the aluminium phosphate molecular sieve of O, room temperature (20 DEG C) exchanges 2 hours, sucking filtration, dries.Repeat above-mentioned steps three times, the obtained aluminium phosphate molecular sieve porous carrier being rich in silver ion.Ag exists in the carrier in the form of an ion, and wherein the content of Ag ion accounts for gross mass is 60%.
The preparation of alginate solution: solution potassium alginate distilled water being mixed with 2% concentration, takes the aluminium phosphate molecular sieve porous carrier 7g being rich in Ag ion, joins in the potassium alginate solution of the above-mentioned concentration of 100mL, continues stirring 2 hours.
The preparation of gel: by the cobalt chloride solution of 5% in 5% ratio pour in the sodium alginate soln of argentiferous carrier of above-mentioned concentration, form gel under being allowed to condition at room temperature (20 DEG C) condition.The content of the gel silver ion of final preparation is 4%.
Silver ion slow release effect is measured: embodiment 6 is prepared into silver ion alginate sustained-release antibacterial gel, and the release time of silver ion can continue more than 90 hours, and the releasing ratio of silver ion has exceeded 85%.
Claims (13)
1. a silver ion alginate sustained-release antibacterial gel, is characterized in that, effective ingredient is silver ion, and gel-type vehicle is alginate, and silver ion content counts 0.001% to 10% with silver ion quality;
The release time of silver ion continues more than 50 hours, and silver ion releasing ratio is more than 70%;
Described gel is evenly spread in alginate solution by the porous carrier of rich carrying silver ion, then add that high-valence cationic obtains.
2. a silver ion alginate sustained-release antibacterial gel as claimed in claim 1, it is characterized in that, described porous carrier comprises type A zeolite molecular sieve, X-type zeolite molecular sieve, Y-type zeolite molecular sieve, natural mordenite molecular sieve, natural clinoptilolite molecular sieve, synthesizing Si-Al zeolite molecular sieve, aluminium phosphate molecular sieve, mesopore molecular sieve or brucite.
3. a silver ion alginate sustained-release antibacterial gel as claimed in claim 1, it is characterized in that, described high-valence cationic comprises Ca
2+, Zn
2+, Mn
2+, Fe
2+, Fe
3+, Al
3+, Co
2+and/or Cu
2+.
4. a preparation method for silver ion alginate sustained-release antibacterial gel, evenly spreads to the porous carrier of rich carrying silver ion in alginate solution, then adds high-valence cationic and obtain gel;
It is characterized in that, comprise the following steps:
A, utilize the zeolite molecular sieve with ion exchanging function of high-specific surface area and silver ion solution to carry out ion exchange, the porous carrier of silver ion is rich in preparation;
B, prepare alginate solution;
C, the porous carrier being rich in silver ion in a is joined in b in alginate solution, dispersed;
D, in dispersion liquid in c, add high-valence cationic solution, stir, leave standstill and form gel;
Being rich in silver ion content in the porous carrier of silver ion is 5% ~ 75% of porous carrier gross mass in mass; Alginate solution concentration is 1% ~ 50% in mass.
5. the preparation method of silver ion alginate sustained-release antibacterial gel as claimed in claim 4, it is characterized in that, alginate comprises sodium alginate or potassium alginate.
6. the preparation method of silver ion alginate sustained-release antibacterial gel as claimed in claim 5, it is characterized in that, porous carrier comprises type A zeolite molecular sieve, X-type zeolite molecular sieve, Y-type zeolite molecular sieve, natural mordenite molecular sieve, natural clinoptilolite molecular sieve, synthesizing Si-Al zeolite molecular sieve, aluminium phosphate molecular sieve, mesopore molecular sieve or brucite.
7. the preparation method of silver ion alginate sustained-release antibacterial gel as claimed in claim 6, it is characterized in that, silver ion solution is silver nitrate or silver acetate solutions, and ion-exchange temperature is that room temperature is to 80 DEG C.
8. the preparation method of silver ion alginate sustained-release antibacterial gel as claimed in claim 7, is characterized in that, the addition of the porous carrier being rich in silver ion in alginate solution is in mass/volume, and unit g/mL is 0.01% ~ 20%.
9. the preparation method of silver ion alginate sustained-release antibacterial gel as described in as arbitrary in claim 4-8, it is characterized in that, high-valence cationic concentration counts 0.5% ~ 85% with high-valence cationic salt quality, addition is equal alginate solution by volume 1% ~ 50%, becomes gelling temp to be that room temperature is to 80 DEG C.
10. the preparation method of silver ion alginate sustained-release antibacterial gel as claimed in claim 9, it is characterized in that, described high-valence cationic comprises Ca
2+, Zn
2+, Mn
2+, Fe
2+, Fe
3+, Al
3+, Co
2+and/or Cu
2+.
The preparation method of 11. silver ion alginate sustained-release antibacterial gels as claimed in claim 10, it is characterized in that, described high-valence cationic exists in solution with acetate, nitrate, sulfate or chloride.
The preparation method of 12. silver ion alginate sustained-release antibacterial gels as claimed in claim 11, it is characterized in that, type A zeolite molecular sieve comprises NaA, KA, CaA, and described X-type zeolite molecular sieve comprises NaX, LiX, HX, CaX, and described Y-type zeolite molecular sieve comprises MgY, NaY, CaY, HY.
The preparation method of 13. silver ion alginate sustained-release antibacterial gels as claimed in claim 12, it is characterized in that, the molecular composition of Si-Al zeolite molecular sieve of described type A zeolite molecular sieve, X-type zeolite molecular sieve, Y-type zeolite molecular sieve, natural clinoptilolite molecular sieve, natural mordenite molecular sieve (MOR) and synthesis is 0.5 ~ 15molNa
2o, 0.5 ~ 14molSiO
2, 0.5 ~ 10molAl
2o
3, 0.1 ~ 20molH
2o; Described aluminium phosphate molecular sieve molecular composition is 0.5 ~ 10molNa
2o, 0.5 ~ 14molP
2o
5, 0.5 ~ 10molAl
2o
3, 0.1 ~ 30molH
2o; Described mesopore molecular sieve consists of 0.5 ~ 14molSiO
2, 0.1 ~ 30molH
2o.
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| EP3660191B1 (en) | 2017-07-25 | 2022-04-27 | Huizhou Foryou Medical Devices Co., Ltd. | Antimicrobial alginate fibre, and preparation method for and use of dressing thereof |
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| CN115381854B (en) * | 2022-07-07 | 2024-02-20 | 广东省科学院生物与医学工程研究所 | Injectable antibacterial composite material and preparation method and application thereof |
| CN115227867B (en) * | 2022-07-07 | 2023-11-10 | 广东省科学院生物与医学工程研究所 | Antibacterial composite material and preparation method and application thereof |
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