CN111012680A - Novel tea-based antioxidant - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Abstract
A novel tea-based antioxidant comprises a gel carrier and an antioxidant active substance, wherein the gel carrier is synthesized by sodium alginate and calcium ions, and the antioxidant active substance comprises EGCG active ingredients; further, the preparation process of the gel carrier comprises the following steps: (1) mixing sodium alginate and water to form a solution a with the concentration of 1-10%; (2) preparing and synthesizing 0.1-10% of calcium ion solution, adding EGCG, and stirring and mixing to obtain solution b; (3) and mixing the solution a and the solution b, fully reacting, rinsing with water, and drying to obtain the antioxidant finished product. According to the invention, the active substance EGCG in the tea base with poor stability is placed in the gel synthesized by sodium alginate and calcium ions to prepare the antioxidant, so that the application range of the EGCG can be effectively widened, and meanwhile, the obtained antioxidant has a slow release effect, is green and safe, and has a simple preparation process.
Description
Technical Field
The invention belongs to the technical field of daily-use chemical industry, and particularly relates to a novel tea-based antioxidant.
Background
Tea is a recognized healthy beverage and has certain special health-care effects, wherein the tea mainly has tea polyphenol in the tea, and the tea polyphenol has important application in the fields of food processing, medicines, daily chemical industry and the like. The tea polyphenol has the main effect of catechin components, and the component with the strongest effect is catechin EGCG.
Research shows that Epigallocatechin gallate (EGCG) is a characteristic monomer component in tea, and has a strong proton providing capability due to the fact that the chemical structure of EGCG has more ortho-phenolic hydroxyl groups (not less than 3), and shows excellent antioxidant performance. In addition, research proves that EGCG also has obvious pharmacological actions of resisting and preventing cancers, resisting bacteria, viruses, inflammation, cardiovascular and cerebrovascular diseases, mutation, nerve regulation, aging resistance, liver function improvement and the like. However, EGCG has large polarity, strong water solubility, difficult oil dissolution, easy influence of light, heat, oxygen and pH, poor stability and low bioavailability, and the factors greatly limit the application of the EGCG in oil-containing products and play better physiological and pharmacological activities. Therefore, the EGCG is coated by selecting a proper carrier, so that the stability of the EGCG can be improved, and the application tediousness of the EGCG is widened; at present, a large number of carriers with bilayer structure have been used for coating EGCG, such as ethosome, liposome, niosome, etc.
The liposome-like body is mainly composed of a nonionic surfactant, and compared with a liposome mainly composed of phospholipid, the cost of the liposome-like body is lower, and the oxidation stability is better, however, the liposome-like carrier has a bilayer structure and high membrane fluidity, so that leakage of active substances or medicines is easily caused, and how to prepare a preparation method which is stable, has high retention rate and can obtain a good EGCG slow release effect is a problem to be solved urgently.
The application publication No. CN109464298A discloses a preparation method of EGCG liposome and EGCG liposome gel, wherein the PVA/HA/EGCG liposome gel is obtained by loading EGCG liposome into gel on the basis of preparing EGCG liposome with small particle size and high entrapment rate by ethanol injection-high speed dispersion; the gel is not introduced with a chemical cross-linking agent, is more green and mild, HAs good biocompatibility, HAs better sustained-release effect than PVA/HA/EGCG gel, can control the release speed of EGCG by regulating the content of PVA and HA, and HAs potential application value in the aspects of active matter sustained release of cosmetics and drug controlled release of biological medicines. However, in the reference of primary arrangement of carcinogen lists published by international cancer research institution of world health organization international cancer in 2017, 10, 27 and in the three types of carcinogen lists, the PVA (polyvinyl alcohol) used in the scheme is not suitable for being applied to the fields of cosmetics and biomedicine, so that a safer and more reliable material is selected for preparation.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a novel tea-based antioxidant, which is prepared by putting an active substance EGCG in a tea base with poor stability into a gel synthesized by sodium alginate and calcium ions, so that the application range of the EGCG can be effectively widened, and meanwhile, the obtained antioxidant has a slow release effect, is green and safe and has a simple preparation process.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a novel tea-based antioxidant comprises a gel carrier and an antioxidant active substance, wherein the gel carrier is synthesized by sodium alginate and calcium ions, and the antioxidant active substance comprises EGCG active ingredients; further, the preparation process of the gel carrier comprises the following steps: (1) mixing sodium alginate and water to form a solution a with the concentration of 1-10%; (2) preparing and synthesizing 0.1-10% of calcium ion solution, adding EGCG, and stirring and mixing to obtain solution b; (3) and mixing the solution a and the solution b, fully reacting, rinsing with water, and drying to obtain the antioxidant finished product.
In the design of the scheme, edible sodium alginate is selected to rapidly form gel and have irreversible property with calcium ions under extremely mild conditions, the gel is used as a carrier of EGCG active substances with poor stability extracted from tea base, the inactivation of the EGCG and other active substances can be avoided, the gel strength, elasticity and water retention of the prepared sodium alginate are good, the slow-release effect is achieved, and the gel is used as an excellent carrier of an antioxidant in the design of the scheme.
Further, the calcium ion solution is prepared from calcium hydrophosphate and citric acid.
In the design of the scheme, a common calcium chloride solution is selected as a reagent for preparing a carrier of the antioxidant, which may be irritant or harmful to human skin or human body, so that the edible grade calcium hydrophosphate and the excessive citric acid react to obtain free calcium ions, and the free calcium ions react with the sodium alginate to prepare the gel carrier, which is safer and more reliable.
Further, the reaction temperature of the solution a and the solution b in the step (3) is 20-60 ℃, the reaction time is 30-90 min, and preferably 50-60 ℃.
In the design of the scheme, the release performance of the gel needs to be improved by controlling the conditions of the gel reaction, the sodium alginate intermolecular chain segment is wound at the temperature of 20-60 ℃ to obtain certain stretching, the sodium alginate intermolecular chain segment is favorably combined with calcium ions to form a network structure, and the prepared gel has high strength, good elasticity and low dehydration rate and is a better carrier; preferably, the reaction is carried out at 50-60 ℃ to prevent citric acid and calcium ions from forming precipitates which are not beneficial to the formation of gel.
Further, a mixed solution c is prepared, wherein the main components of the mixed solution c comprise glycerin and HA, and the mass ratio of the HA to the glycerin is 1: 1.5-20.
In the design of the scheme, the glycerol is added, so that the toughness of the gel can be improved, the burst release effect of the gel is reduced, and the release performance of the gel is improved; meanwhile, the glycerol is a good co-emulsifier, helps other synergistic components such as HA and the like to form and stabilize the monomer droplets in submicron order, and ensures that the effective components play a role; HA, hyaluronic acid, is used as a synergist to promote the absorption of active substances by the skin when used as an antioxidant, and HAs moisturizing and repairing effects.
Preferably, the preparation process of the gel carrier comprises the following steps: and mixing the mixed solution c with the solution a to obtain a mixed solution d, adding the mixed solution b into the mixed solution d, adding a buffer solution to adjust the pH value to 2.0-5.5, reacting while stirring, rinsing with water, and drying to obtain an antioxidant finished product.
Preferably, the buffer solution comprises: phosphate buffer solution, citric acid-citrate buffer solution, acetate buffer solution, preferably citric acid-citrate buffer solution.
Preferably, the molecular weight of said HA is 5.0 x 105-2.1*106。
Preferably, the particle size of the sodium alginate is 100-300 meshes.
The invention has the following beneficial effects:
according to the scheme, the antioxidant is prepared by coating and bearing the active substance EGCG in the tea base with the gel, so that the stability and retention rate of the active substance can be effectively improved, and the prepared antioxidant product is mild and green, has a good slow release effect, and has a good application value in the field of cosmetics.
Drawings
Fig. 1 is a time-EGCG release rate line graph of an embodiment of the present invention.
Detailed Description
Example 1
The novel tea-based antioxidant consists of:
EGCG, sodium alginate, calcium hydrophosphate, citric acid, 0.1M citric acid-sodium citrate buffer solution, glycerol, hyaluronic acid and deionized water.
Every 100 parts of sodium alginate gel contains 10 parts of EGCG, 2 parts of sodium alginate, 0.4 part of calcium hydrophosphate, 2.5 parts of citric acid, 5 parts of glycerol and 0.5 part of hyaluronic acid in parts by mass.
The preparation method of the novel tea-based antioxidant comprises the following steps:
(1) molecular weight of 1.5 x 106Dissolving Da hyaluronic acid (Shandong Furuida Biochemical Co., Ltd.) in deionized water at a ratio of 1:2 (mass ratio), adding glycerol after hyaluronic acid is fully swelled, and obtainingTo solution c.
(2) Sodium alginate (10 mg/ml aqueous solution with a particle size of 200 mesh, viscosity of 205 mPa.s at 25 ℃, Qingdao crystal biotechnology limited) is dissolved in deionized water to prepare a solution a with a concentration of 1.0% (g/100 ml).
(3) Adding deionized water into citric acid (with a particle size of 80 meshes) to prepare a citric acid solution with a concentration of 1.0%, heating the citric acid solution in a water bath to 60 ℃, adding calcium hydrophosphate (with a particle size of 200 meshes, from Hibei Kelong Biotech Co., Ltd.) to saturate the solution, adding EGCG, and stirring uniformly to obtain a solution b.
(4) And uniformly mixing the solution c and the solution a to obtain a mixed solution d, then adding the solution b while starting stirring in a plain mode, stirring at room temperature for 60min, and dropwise adding 0.1mol/L citric acid-sodium citrate during stirring to keep the pH value of the reaction at 4.75 to obtain the transparent sodium alginate gel.
(5) Repeatedly washing the formed gel with deionized water for at least 5 times, wherein the washing time is not less than 20min, and slowly turning the gel during washing to dissolve the residual reaction impurities in water for removal.
The sodium alginate gel, namely the antioxidant, prepared by the method is light yellow, and has certain hardness, toughness and viscoelasticity.
Example 2
The novel tea-based antioxidant consists of:
EGCG, sodium alginate, calcium hydrophosphate, citric acid, 0.1M citric acid-sodium citrate buffer solution, glycerol, hyaluronic acid and deionized water.
Every 100 parts of sodium alginate gel contains 10 parts of EGCG, 2 parts of sodium alginate, 1 part of calcium hydrophosphate, 4 parts of citric acid, 3 parts of glycerol and 0.5 part of hyaluronic acid in parts by mass.
The preparation method of the novel tea-based antioxidant comprises the following steps:
(1) molecular weight 2.0 x 106Da hyaluronic acid (Shandong Furuida Biochemical Co., Ltd.) was dissolved in a ratio (mass ratio) of 1:2And (3) adding glycerol after hyaluronic acid is fully swelled in deionized water to obtain a solution c.
(2) Sodium alginate (10 mg/ml aqueous solution with a particle size of 200 mesh, viscosity of 205 mPa.s at 25 ℃, Qingdao crystal biotechnology limited) is dissolved in deionized water to prepare a solution a with a concentration of 1.0% (g/100 ml).
(3) Adding deionized water into citric acid (with a particle size of 80 meshes) to prepare a citric acid solution with a concentration of 1.0%, heating the citric acid solution in a water bath to 50 ℃, adding calcium hydrophosphate (with a particle size of 200 meshes, from Hibei Kelong Biotech Co., Ltd.) to saturate the solution, adding EGCG, and stirring uniformly to obtain a solution b.
(4) And uniformly mixing the solution c and the solution a to obtain a mixed solution d, then adding the solution b while starting stirring in a plain mode, stirring at room temperature for 60min, and dropwise adding 0.1mol/L citric acid-sodium citrate during stirring to keep the pH value of the reaction at 4.5, thereby obtaining the transparent sodium alginate gel.
(5) Repeatedly washing the formed gel with deionized water for at least 5 times, wherein the washing time is not less than 20min, and slowly turning the gel during washing to dissolve the residual reaction impurities in water for removal.
The sodium alginate gel, namely the antioxidant, prepared by the method is light yellow, and has certain hardness, toughness and viscoelasticity.
Example 3
The novel tea-based antioxidant consists of:
EGCG, sodium alginate, calcium hydrophosphate, citric acid, 0.1M citric acid-sodium citrate buffer solution, glycerol, hyaluronic acid and deionized water.
Every 100 parts of sodium alginate gel contains 15 parts of EGCG, 2 parts of sodium alginate, 1.0 part of calcium hydrophosphate, 5 parts of citric acid, 4 parts of glycerol and 0.5 part of hyaluronic acid in parts by mass.
The preparation method of the novel tea-based antioxidant comprises the following steps:
(1) molecular weight of 1.5 x 106Da hyaluronic acid (Shandong)Forrida biochemical engineering Co., Ltd.) was dissolved in deionized water at a ratio (mass ratio) of 1:2, and after hyaluronic acid was sufficiently swollen, glycerin was added to obtain a solution c.
(2) Sodium alginate (10 mg/ml aqueous solution with a particle size of 200 mesh, viscosity of 205 mPa.s at 25 ℃, Qingdao crystal biotechnology limited) is dissolved in deionized water to prepare a solution a with a concentration of 1.0% (g/100 ml).
(3) Adding deionized water into citric acid (with a particle size of 80 meshes) to prepare a citric acid solution with a concentration of 1.0%, heating the citric acid solution in a water bath to 60 ℃, adding calcium hydrophosphate (with a particle size of 200 meshes, from Hibei Kelong Biotech Co., Ltd.) to saturate the solution, adding EGCG, and stirring uniformly to obtain a solution b.
(4) And uniformly mixing the solution c and the solution a to obtain a mixed solution d, then adding the solution b while starting stirring in a plain mode, stirring at room temperature for 40min, and dropwise adding 0.1mol/L citric acid-sodium citrate during stirring to keep the pH value of the reaction at 4.75 to obtain the transparent sodium alginate gel.
(5) Repeatedly washing the formed gel with deionized water for at least 5 times, wherein the washing time is not less than 20min, and slowly turning the gel during washing to dissolve the residual reaction impurities in water for removal.
The sodium alginate gel, namely the antioxidant, prepared by the method is light yellow, and has certain hardness, toughness and viscoelasticity.
Comparative example 1
This example differs from example 1 in that no glycerol was added.
Comparative example 2
The difference between the present example and example 1 is that glycerol is contained in an amount of 1 part by mass per 100 parts by mass of the sodium alginate gel.
Comparative example 3
The difference between the present example and example 1 is that glycerol is contained in an amount of 2 parts by mass per 100 parts by mass of the sodium alginate gel.
Comparative examples 4 to 7
The difference from the embodiment is that each 100 parts of sodium alginate gel contains 1.0 part, 1.5 parts, 2.5 parts and 3 parts of sodium alginate by mass, and the content of the rest components is constant.
The release characteristics of the antioxidants prepared in examples 1-3 and comparative examples 1-3 were tested, with examples 1-3 labeled a-c and comparative examples 1-3 labeled d-f;
as can be seen from the attached figure 1, the release rate of the EGCG is slowed down along with the increase of the addition amount of the glycerol, the sudden release effect is most obvious when the glycerol is not added to the antioxidant d, the release effect is most gentle when the antioxidant a is added to the maximum amount, and the final release effect differences of a to f are not large, so that the final EGCG release effect is not influenced by the addition of the glycerol.
The antioxidant gels prepared in example 1 and comparative examples 4 to 7 were tested for gel strength, elasticity (texture measurement), and dehydration rate before and after freezing (dehydration rate = (W)1-W2）/W1100%), labeled a-D, with the results shown in the following table:
according to the table, the appearance characteristics of the gel gradually become better along with the increase of the concentration of the sodium alginate, the antioxidant A has thin gel, poor toughness, easy breakage in stretching and poor elasticity, the frozen ice crystal is large, the gel is layered after being thawed, and the surface of the gel is wrinkled and inelastic; d, the antioxidant gel is thick in colloid, compact in glue layer, good in elastic toughness, small in ice crystal and thin in ice layer after being frozen, and has smooth, non-layered and elastic surface after being unfrozen; the dehydration rate also decreases with the increase of the concentration of sodium alginate; however, the gel property required for preparing the antioxidant product cannot be too thin or too thick, so the effect of selecting the sodium alginate with medium concentration is optimal.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.
Claims (8)
1. A novel tea-based antioxidant comprises a gel carrier and an antioxidant active substance, and is characterized in that the gel carrier is synthesized by sodium alginate and calcium ions, the antioxidant active substance comprises EGCG active ingredients, and the preparation process of the gel carrier comprises the following steps: (1) mixing sodium alginate and water to form a solution a with the concentration of 1-10%; (2) preparing and synthesizing 0.1-10% of calcium ion solution, adding EGCG, and stirring and mixing to obtain solution b; (3) and (4) mixing the solution a and the solution b for reaction, rinsing with water, and drying to obtain the antioxidant finished product.
2. A novel tea based antioxidant as claimed in claim 2 wherein the calcium ion solution is formulated from calcium hydrogen phosphate and citric acid.
3. The novel tea-based antioxidant as claimed in claim 2, wherein the reaction temperature of the solution a and the solution b in the step (3) is 20-60 ℃ and the reaction time is 30-90 min.
4. The novel tea-based antioxidant according to claim 2, characterized in that a mixed solution c is prepared, the main components of which comprise glycerin and HA, wherein the mass ratio of HA to glycerin is 1: 1.5-20.
5. A novel tea based antioxidant as claimed in claim 4 wherein the gel carrier is prepared by a process comprising: and mixing the mixed solution c with the solution a to obtain a mixed solution d, adding the mixed solution b into the mixed solution d, adding a buffer solution to adjust the pH value to 2.0-5.5, reacting while stirring, rinsing with water, and drying to obtain an antioxidant finished product.
6. A novel tea based antioxidant as claimed in claim 5 wherein the buffer solution comprises: phosphate buffer solution, citric acid-citrate buffer solution, acetate buffer solution.
7. A novel tea-based antioxidant according to any one of claims 4 to 6 wherein the HA HAs a molecular weight of 5.0 x 105-2.1*106。
8. The novel tea-based antioxidant as set forth in claim 1, wherein the particle size of sodium alginate is 100-300 mesh.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529434A (en) * | 2020-05-11 | 2020-08-14 | 山东农业大学 | Lip prevention and health care product containing EGCG and application thereof |
| CN115736159A (en) * | 2022-11-09 | 2023-03-07 | 奕威能生物科技(江苏)有限公司 | High-temperature and high-humidity resistant antioxidant for feed and preparation method thereof |
| CN115736159B (en) * | 2022-11-09 | 2024-04-19 | 奕威能生物科技(江苏)有限公司 | High-temperature-resistant high-humidity antioxidant for feed and preparation method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552546A (en) * | 2010-12-30 | 2012-07-11 | 无锡纳诺生物科技有限公司 | Tea polyphenol sodium alginate microsphere and preparation method and application thereof |
| CN102583741A (en) * | 2012-03-01 | 2012-07-18 | 南京大学 | Slow-release carbon source material using sodium alginate as base material and preparation method thereof |
| CN103110107A (en) * | 2013-01-20 | 2013-05-22 | 浙江大学 | Method for wrapping tea polyphenol by using protein gel |
| CN103768643A (en) * | 2014-02-17 | 2014-05-07 | 周继胡 | Silver ion alginate sustained-release antibacterial gel and preparation method thereof |
| CN104856963A (en) * | 2015-05-26 | 2015-08-26 | 大连理工大学 | Astaxanthin-sodium alginate sustained release microspheres as well as preparation method and application thereof |
| CN104921964A (en) * | 2015-06-09 | 2015-09-23 | 上海应用技术学院 | Carrageenan-tea polyphenol microsphere with oxidation resistance, as well as preparation method and use thereof |
| CN108659240A (en) * | 2018-04-04 | 2018-10-16 | 山东大学 | A kind of controllable sustained-release green gel and the preparation method and application thereof based on alkyl polyglucoside |
| CN109464298A (en) * | 2018-11-20 | 2019-03-15 | 江南大学 | A kind of preparation method and EGCG lipoid plastid gel of EGCG lipoid plastid gel |
| CN109864982A (en) * | 2019-03-22 | 2019-06-11 | 大连医诺生物股份有限公司 | Epigallo-catechin gallate (EGCG) microcapsule powder and preparation method thereof |
| CN110327227A (en) * | 2019-08-01 | 2019-10-15 | 上海应用技术大学 | A kind of hydrogel microsphere and preparation method thereof containing ellagic acid |
-
2019
- 2019-11-25 CN CN201911163881.8A patent/CN111012680A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552546A (en) * | 2010-12-30 | 2012-07-11 | 无锡纳诺生物科技有限公司 | Tea polyphenol sodium alginate microsphere and preparation method and application thereof |
| CN102583741A (en) * | 2012-03-01 | 2012-07-18 | 南京大学 | Slow-release carbon source material using sodium alginate as base material and preparation method thereof |
| CN103110107A (en) * | 2013-01-20 | 2013-05-22 | 浙江大学 | Method for wrapping tea polyphenol by using protein gel |
| CN103768643A (en) * | 2014-02-17 | 2014-05-07 | 周继胡 | Silver ion alginate sustained-release antibacterial gel and preparation method thereof |
| CN104856963A (en) * | 2015-05-26 | 2015-08-26 | 大连理工大学 | Astaxanthin-sodium alginate sustained release microspheres as well as preparation method and application thereof |
| CN104921964A (en) * | 2015-06-09 | 2015-09-23 | 上海应用技术学院 | Carrageenan-tea polyphenol microsphere with oxidation resistance, as well as preparation method and use thereof |
| CN108659240A (en) * | 2018-04-04 | 2018-10-16 | 山东大学 | A kind of controllable sustained-release green gel and the preparation method and application thereof based on alkyl polyglucoside |
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