CN108815317A - A kind of preparation process of radix tetrastigme freeze-dried powder - Google Patents
A kind of preparation process of radix tetrastigme freeze-dried powder Download PDFInfo
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- CN108815317A CN108815317A CN201810815195.3A CN201810815195A CN108815317A CN 108815317 A CN108815317 A CN 108815317A CN 201810815195 A CN201810815195 A CN 201810815195A CN 108815317 A CN108815317 A CN 108815317A
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B1/00—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids
- F26B1/005—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids by means of disintegrating, e.g. crushing, shredding, milling the materials to be dried
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- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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Abstract
The invention discloses a kind of preparation processes of radix tetrastigme freeze-dried powder, including step：1) it pre-processes, after fresh radix tetrastigme stem tuber is carried out ultrasonic cleaning, dried, is ground into coarse powder with roughing mill；2) pre-freeze is handled, at -60~-65 DEG C, 2~3h of pre-freeze；3) Freezing smashing, the radix tetrastigme coarse powder of pre-freeze is crushed again by further cooling make up to after -65 DEG C of glass transition temperature, radix tetrastigme freeze-dried powder after pulverized is classified and is collected by fish grading machine of gas flow screen, and the radix tetrastigme powder for not reaching 500 mesh fineness requirements, which returns to feed bin, to be continued to crush；4) vacuum freeze drying, -65 DEG C of condenser temperature, 10 ± 5Pa of freeze drying box pressure, using radiant heating method, the radix tetrastigme powder temperature of pre-freeze is strictly kept to be lower than -38 DEG C of plait point temperature in drying process, the effective component of the radix tetrastigme freeze-dried powder of preparation retains more complete, it is more preferable to take rear effect, it takes rear human body to be easier to absorb, be unlikely to deteriorate, the time that can be stored is longer.
Description
Technical field
The present invention relates to a kind of preparation processes of radix tetrastigme freeze-dried powder.
Background technique
Radix tetrastigme (Tetrastigma hemsleyanum Diels et Gilg) belongs to Vitaceae Tetrastigma plant,
Its underground root tuber and herb can all be used as medicine, and be the distinctive rare rare Chinese medicine in China, wherein producing the performance optimal of radix tetrastigme with Zhejiang.
According to《Compendium of Materia Medica》It records, radix tetrastigme is cool in nature, nontoxic, sweet and slightly bitter taste, has the effect of clearing heat and detoxicating, promoting blood circulation by removing wind.In radix tetrastigme
Chemical component is many kinds of, is known as " the natural composite plant antibiotic of wide spectrum ".The main chemical compositions of radix tetrastigme have flavones, Huang
Ketoside, polysaccharide, steroid, amino acid, starch etc., by modern pharmacological studies have shown that radix tetrastigme has heat dissipation, qi-regulating, work
Blood, tonifying spleen, removing toxic substances, wind-dispelling, anti-inflammatory, analgesia, antiviral, liver protection, strengthen immunity, it is antitumor the effects of；Radix tetrastigme is anti-swollen
In tumor clinical application, by more cancer kind (lung cancer, breast cancer, gastric cancer, malignant lymphoma, liver cancer, kidney, nasopharyngeal carcinoma, uterus
Cancer, chronic myelocytic leukemia, Huppert's disease etc.) clinical observation, according to the World Health Organization (WHO) to malignant tumour
Curative effect determinate standard counts total effective rate up to 78.33%；Meanwhile discovery is used to treat infantile hyperpyrexia, chronic in conventional therapy
Sphagitis, tonsillitis, hepatitis, pneumonia, gastritis, scrofula and snake bite etc. have special effect.Therefore food of Zhejiang Province drug
Radix tetrastigme is included in Zhejiang Province's Chinese medicine preparation specification register by Surveillance Authority, and together with the units such as Chinese medicine management board of Zhejiang Province
Radix tetrastigme Chinese medicine " new eight Zhe's " was classified as in 2018 to be widelyd popularize.
The eating method of traditional radix tetrastigme is fairly simple, generallys use decoction or dries levigation and swallows, but some suppression cancers
Efficacy component depend merely on decocting and can not be precipitated, and drying levigation can be such that a big chunk effective component is lost, and cause drug effect concentration
Not enough, the effective component for extracting radix tetrastigme is used to be taken, although effect is preferable, extraction process is complicated, extraction cost
It is higher, it is difficult to carry out the popularization of large area；Therefore by radix tetrastigme at low temperature freeze preservation be made " radix tetrastigme freeze-dried powder " just at
Only selection, this preparation process can retain the effective active composition of radix tetrastigme to greatest extent, and can make the patient side of taking
Just, effect is good, solves the problems, such as that radix tetrastigme extracts complicated, expensive, popularization hardly possible.
Existing radix tetrastigme powder largely uses heated-air drying, and the effective component contained is allowed in radix tetrastigme to be largely lost；It adopts
With antivacuum frozen drying, the inorganic salts contained in radix tetrastigme can be made as the drying of moisture is to surface migration, lead to three
The Surface hardened layer of leaf blueness powder stirs difficulty when taking after mixing it with water, absorb after taking slowly, rear effect is taken in influence；The system of part freeze-dried powder
The temperature of Preparation Method, pre-freeze and crushing not enough (- 40 DEG C or less), causes effective component to keep incomplete, partially containing thermal sensitivity
Active constituent is lost.
Summary of the invention
The present invention effectively prevent effective component in radix tetrastigme to be lost in order to solve the above technical problems, providing one kind, is allowed to take
It is more preferable with rear effect, greatly improve the preparation process of the quality of radix tetrastigme freeze-dried powder and the radix tetrastigme freeze-dried powder of effect.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of preparation process of radix tetrastigme freeze-dried powder, including step：
1) it pre-processes
After fresh radix tetrastigme stem tuber is carried out ultrasonic cleaning, dried, coarse powder is ground into roughing mill；
2) pre-freeze is handled
At -60~-65 DEG C, 2~3h of pre-freeze；
3) Freezing smashing
The radix tetrastigme coarse powder of pre-freeze is subjected to powder by further cooling make up to again after -65 DEG C of glass transition temperature
Broken, the radix tetrastigme freeze-dried powder after being crushed is classified and is collected by fish grading machine of gas flow screen, does not reach 500 mesh fineness requirements
Radix tetrastigme powder, which returns to feed bin, to be continued to crush；
4) vacuum freeze drying
The setting of vacuum freeze drier：
- 65 DEG C of condenser temperature, vacuum degree：Freeze drying box 10 ± 5Pa of pressure is tight in drying process using radiant heating method
The plait point temperature that lattice keep the radix tetrastigme powder temperature of pre-freeze to be lower than -38 DEG C, in the drying process to avoid radix tetrastigme powder
Temperature rises the fine structure too fast, the ice crystal thawing destruction freezing for forming pre-freeze is set up, and fine structure is made to collapse
It falls into, blocks moisture distillation causes freeze-drying to fail.
The radix tetrastigme stem tuber that radix tetrastigme stem tuber selects growth to expire 4 years in the step 1) as a preferred technical solution,.
As a preferred technical solution, in the step 1), it is 20khz that the ultrasonication, which selects wave band,；The powder
The coarse powder partial size being broken into is 20~30 mesh.
The eutectic point of step 2) the pre-freeze processing radix tetrastigme, plait point use electric-resistivity method as a preferred technical solution,
It measures.
The specific test method of the electric-resistivity method is as a preferred technical solution,：With market universal tester general-purpose
Table makees ohmer, and cryogenic temperature is counted as temperature element, is frozen in DW-450 super-low temperature pulverizator and completes, and when test visits thermometric
Head and resistance electrode are inserted in parallel into the center of radix tetrastigme stem tuber, and keep the spacing of 2~3cm, draw freezing with conducting wire and set
Standby rear access test macro passes through multimeter reading radix tetrastigme stem tuber synchronous with low-reading thermometer in temperature changing process
Resistance value and temperature, the eutectic point for measuring radix tetrastigme is -43 DEG C, and plait point is -38 DEG C.
The step 3) selects deep cooling type super-low temperature pulverizator as a preferred technical solution, and the pulverizer system is with liquid
Nitrogen is cold source, and smashed product, which has, to never degenerate, and is not aoxidized, even particle size distribution, the good feature of geometric figure.
Freezing smashing temperature is -80 DEG C in the step 3) as a preferred technical solution,.
Radiant heating is that the radix tetrastigme powder that will need to be freeze-dried is placed in the step 4) as a preferred technical solution,
It on basin, is inserted between two panels heating plate, is allowed to and supply heat by heating plate radiation not with contact heater plate,
Therefore heating plate can be heated to the temperature of permissible range or more, and by the temperature of dry radix tetrastigme powder be then maintained at allowable temperature it
It is interior, distillation can be accelerated in this way and shorten drying time, the operation of dry front and back is also easy to, and is especially filled in Large Scale and Continuous drying
It is more efficient in setting.
Advantages of the present invention：
1, the effective component of radix tetrastigme retains more complete, and it is more preferable to take rear effect.
2, when taking after mixing it with water, faster, stirring is easier rehydration the radix tetrastigme freeze-dried powder of this technique preparation, is taken rear human body and is easier to
It absorbs.
3, the radix tetrastigme freeze-dried powder of this technique preparation is unlikely to deteriorate, and the time that can be stored is longer.Due to using above-mentioned skill
Art scheme, a kind of preparation process of radix tetrastigme freeze-dried powder, including step：1) it pre-processes, fresh radix tetrastigme stem tuber is surpassed
Sound wave cleaning after drying, is ground into coarse powder with roughing mill；2) pre-freeze is handled, at -60~-65 DEG C, 2~3h of pre-freeze；3) it freezes
It crushes, the radix tetrastigme coarse powder of pre-freeze is crushed again by further cooling make up to after -65 DEG C of glass transition temperature,
Radix tetrastigme freeze-dried powder after pulverized is classified and is collected by fish grading machine of gas flow screen, and the three of 500 mesh fineness requirements are not reached
Leaf blueness powder, which returns to feed bin, to be continued to crush；4) vacuum freeze drying, the setting of vacuum freeze drier：- 65 DEG C of condenser temperature, vacuum
Degree：Freeze drying box 10 ± 5Pa of pressure strictly keeps the radix tetrastigme powder temperature of pre-freeze using radiant heating method in drying process
Degree is lower than -38 DEG C of plait point temperature, and the effective component of radix tetrastigme retains more complete, takes that rear effect is more preferable, three leaves of preparation
When taking after mixing it with water, faster, stirring is easier rehydration green freeze-dried powder, is taken rear human body and is easier to absorb, is unlikely to deteriorate, the time that can be stored
It is longer.
Specific embodiment
The present invention will be further described below with reference to examples, but protection scope of the present invention is not limited solely to implement
Example.
A kind of preparation process of radix tetrastigme freeze-dried powder, including step：
1) it pre-processes
After fresh radix tetrastigme stem tuber is carried out ultrasonic cleaning, dried, coarse powder is ground into roughing mill；
2) pre-freeze is handled
At -60~-65 DEG C, 2~3h of pre-freeze；
3) Freezing smashing
The radix tetrastigme coarse powder of pre-freeze is subjected to powder by further cooling make up to again after -65 DEG C of glass transition temperature
Broken, the radix tetrastigme freeze-dried powder after being crushed is classified and is collected by fish grading machine of gas flow screen, does not reach 500 mesh fineness requirements
Radix tetrastigme powder, which returns to feed bin, to be continued to crush；
4) vacuum freeze drying
The setting of vacuum freeze drier：
- 65 DEG C of condenser temperature, vacuum degree：Freeze drying box 10 ± 5Pa of pressure is tight in drying process using radiant heating method
The plait point temperature that lattice keep the radix tetrastigme powder temperature of pre-freeze to be lower than -38 DEG C, in the drying process to avoid radix tetrastigme powder
Temperature rises the fine structure too fast, the ice crystal thawing destruction freezing for forming pre-freeze is set up, and fine structure is made to collapse
It falls into, blocks moisture distillation causes freeze-drying to fail.
The radix tetrastigme stem tuber that radix tetrastigme stem tuber selects growth to expire 4 years in the step 1).
In the step 1), it is 20khz that the ultrasonication, which selects wave band,；The coarse powder partial size being ground into be 20~
30 mesh.
The eutectic point of step 2) the pre-freeze processing radix tetrastigme, plait point are measured using electric-resistivity method.
The specific test method of electric-resistivity method is：Make ohmer, cryogenic temperature with market universal tester multimeter
It is counted as temperature element, is frozen in DW-450 super-low temperature pulverizator and completes, is inserted temperature probe is parallel with resistance electrode when test
Enter the center of radix tetrastigme stem tuber, and keep the spacing of 2~3cm, accesses test macro after drawing freezing equipment with conducting wire,
In temperature changing process, pass through the multimeter resistance value and temperature for reading radix tetrastigme stem tuber synchronous with low-reading thermometer, measurement three
The eutectic point of Ye Qing is -43 DEG C, and plait point is -38 DEG C.
The step 3) selects deep cooling type super-low temperature pulverizator, and the pulverizer system is using liquid nitrogen as cold source, smashed production
Product, which have, to never degenerate, and does not aoxidize, even particle size distribution, the good feature of geometric figure.
Freezing smashing temperature is -80 DEG C in the step 3).
Radiant heating is that the radix tetrastigme powder that will need to be freeze-dried is placed on basin in the step 4), is inserted into two
Between piece heating plate, it is allowed to and supply heat by heating plate radiation, therefore heating plate can be heated to hold not with contact heater plate
Perhaps temperature more than range, and be then maintained within allowable temperature by the temperature of dry radix tetrastigme powder, it can accelerate to distil in this way
Shorten drying time, the operation of dry front and back is also easy to, especially more efficient in Large Scale and Continuous drying device.
Embodiment 1：
A kind of preparation process of radix tetrastigme freeze-dried powder, including step：
1) it pre-processes
After fresh radix tetrastigme stem tuber is carried out ultrasonic cleaning, dried, coarse powder is ground into roughing mill；
2) pre-freeze is handled
At -60 DEG C, pre-freeze 2h；
3) Freezing smashing
The radix tetrastigme coarse powder of pre-freeze is subjected to powder by further cooling make up to again after -65 DEG C of glass transition temperature
Broken, the radix tetrastigme freeze-dried powder after being crushed is classified and is collected by fish grading machine of gas flow screen, does not reach 500 mesh fineness requirements
Radix tetrastigme powder, which returns to feed bin, to be continued to crush；
4) vacuum freeze drying
The setting of vacuum freeze drier：
- 65 DEG C of condenser temperature, vacuum degree：Freeze drying box pressure 5Pa is strictly protected in drying process using radiant heating method
The radix tetrastigme powder temperature for holding pre-freeze is lower than -38 DEG C of plait point temperature, to avoid radix tetrastigme powder temperature in the drying process
Rise the fine structure too fast, the ice crystal thawing destruction freezing for forming pre-freeze is set up, collapses fine structure, hinder
Disconnected water sublimed, causes freeze-drying to fail.
The radix tetrastigme stem tuber that radix tetrastigme stem tuber selects growth to expire 4 years in the step 1).
In the step 1), the ultrasonication select wave band be~；The coarse powder partial size being ground into is~mesh.
The eutectic point of step 2) the pre-freeze processing radix tetrastigme, plait point are measured using electric-resistivity method.
The specific test method of electric-resistivity method is：Make ohmer, cryogenic temperature with market universal tester multimeter
It is counted as temperature element, is frozen in DW-450 super-low temperature pulverizator and completes, is inserted temperature probe is parallel with resistance electrode when test
Enter the center of radix tetrastigme stem tuber, and keep the spacing of 2cm, test macro is accessed after drawing freezing equipment with conducting wire, in temperature
It spends in change procedure, by the multimeter resistance value and temperature for reading radix tetrastigme stem tuber synchronous with low-reading thermometer, measures three leaves
Green eutectic point is -43 DEG C, and plait point is -38 DEG C.
The step 3) selects deep cooling type super-low temperature pulverizator, and the pulverizer system is using liquid nitrogen as cold source, smashed production
Product, which have, to never degenerate, and does not aoxidize, even particle size distribution, the good feature of geometric figure.
Freezing smashing temperature is -80 DEG C in the step 3).
Radiant heating is that the radix tetrastigme powder that will need to be freeze-dried is placed on basin in the step 4), is inserted into two
Between piece heating plate, it is allowed to and supply heat by heating plate radiation, therefore heating plate can be heated to hold not with contact heater plate
Perhaps temperature more than range, and be then maintained within allowable temperature by the temperature of dry radix tetrastigme powder, it can accelerate to distil in this way
Shorten drying time, the operation of dry front and back is also easy to, especially more efficient in Large Scale and Continuous drying device.
Embodiment 2：
A kind of preparation process of radix tetrastigme freeze-dried powder, including step：
1) it pre-processes
After fresh radix tetrastigme stem tuber is carried out ultrasonic cleaning, dried, coarse powder is ground into roughing mill；
2) pre-freeze is handled
At -62 DEG C, pre-freeze 2.5h；
3) Freezing smashing
The radix tetrastigme coarse powder of pre-freeze is subjected to powder by further cooling make up to again after -65 DEG C of glass transition temperature
Broken, the radix tetrastigme freeze-dried powder after being crushed is classified and is collected by fish grading machine of gas flow screen, does not reach 500 mesh fineness requirements
Radix tetrastigme powder, which returns to feed bin, to be continued to crush；
4) vacuum freeze drying
The setting of vacuum freeze drier：
- 65 DEG C of condenser temperature, vacuum degree：Freeze drying box pressure 10Pa is strictly protected in drying process using radiant heating method
The radix tetrastigme powder temperature for holding pre-freeze is lower than -38 DEG C of plait point temperature, to avoid radix tetrastigme powder temperature in the drying process
Rise the fine structure too fast, the ice crystal thawing destruction freezing for forming pre-freeze is set up, collapses fine structure, hinder
Disconnected water sublimed, causes freeze-drying to fail.
The radix tetrastigme stem tuber that radix tetrastigme stem tuber selects growth to expire 4 years in the step 1).
In the step 1), it is 20khz that the ultrasonication, which selects wave band,；The coarse powder partial size being ground into is 25
Mesh.
The eutectic point of step 2) the pre-freeze processing radix tetrastigme, plait point are measured using electric-resistivity method.
The specific test method of electric-resistivity method is：Make ohmer, cryogenic temperature with market universal tester multimeter
It is counted as temperature element, is frozen in DW-450 super-low temperature pulverizator and completes, is inserted temperature probe is parallel with resistance electrode when test
Enter the center of radix tetrastigme stem tuber, and keep the spacing of 2.5cm, accesses test macro after drawing freezing equipment with conducting wire,
In temperature changing process, pass through the multimeter resistance value and temperature for reading radix tetrastigme stem tuber synchronous with low-reading thermometer, measurement three
The eutectic point of Ye Qing is -43 DEG C, and plait point is -38 DEG C.
The step 3) selects deep cooling type super-low temperature pulverizator, and the pulverizer system is using liquid nitrogen as cold source, smashed production
Product, which have, to never degenerate, and does not aoxidize, even particle size distribution, the good feature of geometric figure.
Freezing smashing temperature is -80 DEG C in the step 3).
Radiant heating is that the radix tetrastigme powder that will need to be freeze-dried is placed on basin in the step 4), is inserted into two
Between piece heating plate, it is allowed to and supply heat by heating plate radiation, therefore heating plate can be heated to hold not with contact heater plate
Perhaps temperature more than range, and be then maintained within allowable temperature by the temperature of dry radix tetrastigme powder, it can accelerate to distil in this way
Shorten drying time, the operation of dry front and back is also easy to, especially more efficient in Large Scale and Continuous drying device.
Embodiment 3：
A kind of preparation process of radix tetrastigme freeze-dried powder, including step：
1) it pre-processes
After fresh radix tetrastigme stem tuber is carried out ultrasonic cleaning, dried, coarse powder is ground into roughing mill；
2) pre-freeze is handled
At -65 DEG C, pre-freeze 3h；
3) Freezing smashing
The radix tetrastigme coarse powder of pre-freeze is subjected to powder by further cooling make up to again after -65 DEG C of glass transition temperature
Broken, the radix tetrastigme freeze-dried powder after being crushed is classified and is collected by fish grading machine of gas flow screen, does not reach 500 mesh fineness requirements
Radix tetrastigme powder, which returns to feed bin, to be continued to crush；
4) vacuum freeze drying
The setting of vacuum freeze drier：
- 65 DEG C of condenser temperature, vacuum degree：Freeze drying box pressure 15Pa is strictly protected in drying process using radiant heating method
The radix tetrastigme powder temperature for holding pre-freeze is lower than -38 DEG C of plait point temperature, to avoid radix tetrastigme powder temperature in the drying process
Rise the fine structure too fast, the ice crystal thawing destruction freezing for forming pre-freeze is set up, collapses fine structure, hinder
Disconnected water sublimed, causes freeze-drying to fail.
The radix tetrastigme stem tuber that radix tetrastigme stem tuber selects growth to expire 4 years in the step 1).
In the step 1), it is 20khz that the ultrasonication, which selects wave band,；The coarse powder partial size being ground into is 30
Mesh.
The eutectic point of step 2) the pre-freeze processing radix tetrastigme, plait point are measured using electric-resistivity method.
The specific test method of electric-resistivity method is：Make ohmer, cryogenic temperature with market universal tester multimeter
It is counted as temperature element, is frozen in DW-450 super-low temperature pulverizator and completes, is inserted temperature probe is parallel with resistance electrode when test
Enter the center of radix tetrastigme stem tuber, and keep the spacing of 3cm, test macro is accessed after drawing freezing equipment with conducting wire, in temperature
It spends in change procedure, by the multimeter resistance value and temperature for reading radix tetrastigme stem tuber synchronous with low-reading thermometer, measures three leaves
Green eutectic point is -43 DEG C, and plait point is -38 DEG C.
The step 3) selects deep cooling type super-low temperature pulverizator, and the pulverizer system is using liquid nitrogen as cold source, smashed production
Product, which have, to never degenerate, and does not aoxidize, even particle size distribution, the good feature of geometric figure.
Freezing smashing temperature is -80 DEG C in the step 3).
Radiant heating is that the radix tetrastigme powder that will need to be freeze-dried is placed on basin in the step 4), is inserted into two
Between piece heating plate, it is allowed to and supply heat by heating plate radiation, therefore heating plate can be heated to hold not with contact heater plate
Perhaps temperature more than range, and be then maintained within allowable temperature by the temperature of dry radix tetrastigme powder, it can accelerate to distil in this way
Shorten drying time, the operation of dry front and back is also easy to, especially more efficient in Large Scale and Continuous drying device.
Finally it should be noted that：Above embodiments are only to illustrate the present invention and not limit technology described in the invention
Scheme；Therefore, although this specification is referring to above-mentioned each embodiment, the present invention has been described in detail, this
Field it is to be appreciated by one skilled in the art that still can modify to the present invention or equivalent replacement；And all do not depart from this
The technical solution and its improvement of the spirit and scope of invention, should all cover within the scope of the claims of the present invention.
Claims (8)
1. a kind of preparation process of radix tetrastigme freeze-dried powder, which is characterized in that including step：
1) it pre-processes
After fresh radix tetrastigme stem tuber is carried out ultrasonic cleaning, dried, coarse powder is ground into roughing mill；
2) pre-freeze is handled
At -60~-65 DEG C, 2~3h of pre-freeze；
3) Freezing smashing
The radix tetrastigme coarse powder of pre-freeze is crushed again by further cooling make up to after -65 DEG C of glass transition temperature,
Radix tetrastigme freeze-dried powder after pulverized is classified and is collected by fish grading machine of gas flow screen, and the three of 500 mesh fineness requirements are not reached
Leaf blueness powder, which returns to feed bin, to be continued to crush；
4) vacuum freeze drying
The setting of vacuum freeze drier：
- 65 DEG C of condenser temperature, vacuum degree：Freeze drying box 10 ± 5Pa of pressure is strictly protected in drying process using radiant heating method
The radix tetrastigme powder temperature for holding pre-freeze is lower than -38 DEG C of plait point temperature.
2. the preparation process of radix tetrastigme freeze-dried powder as described in claim 1, it is characterised in that：Radix tetrastigme block in the step 1)
The radix tetrastigme stem tuber that stem selects growth to expire 4 years.
3. the preparation process of radix tetrastigme freeze-dried powder as described in claim 1, it is characterised in that：It is described super in the step 1)
It is 20khz that sonicated, which selects wave band,；The coarse powder partial size being ground into is 20~30 mesh.
4. the preparation process of radix tetrastigme freeze-dried powder as described in claim 1, it is characterised in that：Step 2) the pre-freeze processing three
The eutectic point of Ye Qing, plait point are measured using electric-resistivity method.
5. the preparation process of radix tetrastigme freeze-dried powder as claimed in claim 4, it is characterised in that：The electric-resistivity method is specifically tested
Method is：Make ohmer with market universal tester multimeter, cryogenic temperature is counted as temperature element, and it is ultralow to be frozen in DW-450
It is completed in warm pulverizer, when test is inserted in parallel into temperature probe and resistance electrode the center of radix tetrastigme stem tuber, and keeps 2
The spacing of~3cm accesses test macro after drawing freezing equipment with conducting wire, in temperature changing process, by multimeter and low
The synchronous resistance value and temperature for reading radix tetrastigme stem tuber of temperature thermometer, the eutectic point for measuring radix tetrastigme is -43 DEG C, plait point is -
38℃。
6. the preparation process of radix tetrastigme freeze-dried powder as described in claim 1, it is characterised in that：The step 3) selects deep cooling type
Super-low temperature pulverizator, the pulverizer system is using liquid nitrogen as cold source.
7. the preparation process of radix tetrastigme freeze-dried powder as described in claim 1, it is characterised in that：Freezing smashing in the step 3)
Temperature is -80 DEG C.
8. the preparation process of radix tetrastigme freeze-dried powder as described in claim 1, it is characterised in that：Radiant heating in the step 4)
Be that the radix tetrastigme powder that will need to be freeze-dried is placed on basin, be inserted between two panels heating plate, be allowed to not with heating plate
Contact, and heat is supplied by heating plate radiation, therefore heating plate can be heated to the temperature of permissible range or more, and by dry three
The temperature of leaf blueness powder is then maintained within allowable temperature, can be accelerated distillation in this way and be shortened drying time, the operation of dry front and back
Also it is easy to, it is especially more efficient in Large Scale and Continuous drying device.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113144053A (en) * | 2020-11-23 | 2021-07-23 | 王春燕 | A multifunctional radix Apioris Fortunei powder for preventing and treating various diseases |
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