CN105030847A - Preparation method of nanometer Chinese herbal medicine ultrafine powder - Google Patents
Preparation method of nanometer Chinese herbal medicine ultrafine powder Download PDFInfo
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Abstract
The invention relates to a preparation method of nanometer Chinese herbal medicine ultrafine powder. The preparation method comprises the following steps: (1) cutting to-be-processed Chinese medicinal herbs into slices, grinding, placing the obtained powder into a freeze dryer for free drying, and thus obtaining dry Chinese herbal medicine powder with water content being less than 1%; and (2) placing the dry Chinese herbal medicine powder prepared in the step (1) into a fully-closed high-speed centrifugation ultrafine grinder for ultrafine grinding, recovering the Chinese herbal medicine ultrafine powder with grain diameters being smaller than 100nm by adopting a vaporizing electro-static separator, carrying out ultrafine grinding circularly on the Chinese herbal medicine ultrafine powder with grain diameters being not smaller than 100nm till the dry Chinese herbal medicine powder is completely grinded into the Chinese herbal medicine ultrafine powder with grain diameters smaller than 100nm, and thus preparing the nanometer Chinese herbal medicine ultrafine powder. Compared with the prior art, the preparation method has the advantages that the technological conditions are simple, the operation is convenient, the economic cost is low, large-scale generation is facilitated, the activity of the prepared nanometer powder is obviously superior to that of common raw Chinese herbal medicine powder, and thus the effect of improving the efficacy of the medicine is achieved.
Description
Technical field
The invention belongs to Technology of Processing Chinese Herbal Medicines field, relate to a kind of preparation method of nanometer Chinese herbal medicine micropowder.
Background technology
Chinese medicine is that indelible contribution has been made in the existence of the Chinese nation and procreation.Statistical data shows, there is the people of 80% in the whole world using natural drug as basic medical health means, the whole world containing Chinese medicine interior plant amedica sales volume just with annual 10% speed increment, the annual rate of growth in western developed country plant amedica market reaches more than 20%, greatly exceed the growth rate of chemical drugs.
Nanometer Chinese herbal medicine refer to use nanotechnology manufacture, particle diameter is less than the important effective ingredient of 100nm, effective site, former medicine and compound formulation.Along with nanotechnology is on the continuous infiltration in drug research field and impact, the research and development of nanometer Chinese herbal medicine have been provided with the feasibility in theoretic probability and practice.As everyone knows, living organism is an extremely complicated process to the absorption of medicine, metabolism, excretion, and the pharmacodynamics effect that Chinese medicine produces can not give the credit to the chemical composition of medicine uniquely, also should have substantial connection with the chemical composition particle diameter of medicine.Chinese herbal medicine nanorize effectively can increase drug solubility, improves bioavailability, reduces medication, saving Chinese medicaments resource.The physicochemical property of medicine, biological activity generation Chinese medicine may be caused after Chinese medicine is made into nanoparticle to change, make its increased activity, and produce new effect.Therefore, if the particle diameter of medicine can be reduced to nanoscale, the activity of medicine and bioavailability can be greatly improved, and can produce new drug effect.
Application number be 201010502298.8 Chinese invention patent disclose a kind of preparation method of Chinese herbal medicine ultra-fine powder slices for decoction, the method comprises the following steps: by each Chinese herbal medicine after selected on sorting machine, dry in input dehydrator, each Chinese herbal medicine after oven dry, it is less than 6% that its water content controls, and input in micronizer respectively and grind, then input in ultra-fine grinding mill respectively and wear into ultrafine pharmaceutical powders, granularity is 300-1200 order; The adjuvant magnesium stearate of to be the supplementary product starch of 3-6% and percentage by weight by ultrafine pharmaceutical powders and percentage by weight be 1-3% is allocated, and stir in blender, then make ultra-fine powder slices for decoction in molding machine, every sheet ultra-fine powder slices for decoction weight is 1 gram.The technical scheme of this patent disclosure need to add adjuvant with the use of, there is the intervention of allogenic material, and temperature is higher during preparation, this can have an impact to the biological activity of raw material, be unfavorable for the biological activity increasing substantially raw material, the aobvious poor effect of drug effect speed may be caused, be further improved.
Summary of the invention
Object of the present invention is exactly provide a kind of process conditions simple to overcome defect that above-mentioned prior art exists, easy to operate, the preparation method of economical and practical nanometer Chinese herbal medicine micropowder.
Object of the present invention can be achieved through the following technical solutions:
A preparation method for nanometer Chinese herbal medicine micropowder, the method specifically comprises the following steps:
(1) Chinese medicinal herbs to be processed is carried out section to pulverize, then, be placed in freezer dryer, carry out lyophilization, the Chinese herbal medicine dry powder of obtained moisture < 1%;
(2) the Chinese herbal medicine dry powder that step (1) is obtained is placed in totally enclosed type high speed centrifugation ultrafine crusher, carry out superfine grinding, gasification electrostatic separator is adopted to reclaim the Chinese herbal medicine fine powder of particle diameter < 100nm, and superfine grinding is carried out in the Chinese herbal medicine fine powder continuation circulation of particle diameter >=100nm, until the whole superfine grinding of Chinese herbal medicine dry powder is to particle diameter < 100nm, i.e. obtained nanometer Chinese herbal medicine micropowder.
The particle diameter of the Chinese herbal medicine dry powder described in step (1) is 60-80 order.
Cryodesiccated condition described in step (1) is: be first cooled to rapidly-16 ~-22 DEG C by room temperature, freezing 2 ~ 3h, be more slowly warming up to 20 ~ 25 DEG C, and regulate vacuum to be 8 ~ 16Pa, process 2 ~ 3h.
Described rate of temperature fall is 10 ~ 15 DEG C/min.
Described heating rate is 1.2 ~ 2.4 DEG C/min.
The condition of the superfine grinding described in step (2) is: the temperature controlling condensation cycle water is 0 ~ 4 DEG C, and adjustment centrifugal rotational speed is 3000 ~ 4000rpm, and the processing time is 10 ~ 15min.
The nanometer Chinese herbal medicine micropowder adopting the present invention to prepare gained effectively can increase drug solubility, improves bioavailability, reduces medication, saving Chinese medicaments resource, this is due to after medicine makes nanoparticle, considerably increases it and is exposed to surface area in medium, promote the dissolving of medicine; Due to adhesiveness and the small particle diameter of nanoparticle, be conducive to the increase of anelasticity during local application, also the time of contact and the contact area that improve medicine and intestinal wall is conducive to, and easier penetrate tissue gap, improve the absorption efficiency of effective ingredient, simultaneously, because the little surface activity of granule is large, its insoluble composition is also easily attached on intestinal wall and is absorbed, and medical material can be made so really to reach full use, is conducive to improving bioavailability and drug effect.
Compared with prior art, the present invention has following characteristics:
1) employing removal Chinese herbal medicine moisture, ultra-fine two steps of nanometer can obtain nanometer Chinese herbal medicine micropowder, process conditions are simple, and easy to operate, Financial cost is low, be conducive to extension to generate, the nanometer grade powder activity made obviously is better than the former powder of common Chinese herbal medicine;
2) fully can retain the medicinal ingredient of Chinese herbal medicine, after patient takes, can the property of medicine be given full play to, reach the effect improving drug effect;
3) obtained nanometer Chinese herbal medicine micropowder can be processed into lamellar finished product, taking convenience, the absorption efficiency of effective ingredient is high, and bioavailability and drug effect are given prominence to, and store also very convenient.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1:
Aborning, adopt the preparation method of nanometer Chinese herbal medicine micropowder of the present invention to carry out nano level superfine pulverizing to the precious medicinal herbs such as Cordyceps, Ganoderma respectively, and carried out activity experiment, specific experiment data are as follows:
Immunocompetence regulating action before and after table 1 Cordyceps nanometer
| Group | NK cytoactive | NK cytoactive translation data |
| Cordyceps nano ultrafine powders 50mg/kg | 49.5±16.91 | 0.716±0.159 |
| The common fine powder 50mg/kg of Cordyceps | 31.52±18.63 | 0.577±0.12 |
Immunocompetence regulating action before and after table 2 ganoderma nano
| Group | NK cytoactive | NK cytoactive translation data |
| Ganoderma nano micropowder 50mg/kg | 37.39±13.61 | 0.653±0.150 |
| The common fine powder 50mg/kg of Ganoderma | 23.16±13.15 | 0.512±0.130 |
From table 1 and table 2 test result analysis, the Cordyceps nano ultrafine powders adopting the preparation method of nanometer Chinese herbal medicine micropowder of the present invention to obtain and the NK cytoactive of ganoderma nano micropowder are obviously better than the common fine powder of Cordyceps, the common fine powder of Ganoderma, after this has also absolutely proved that Chinese medicine is made into nanoparticle, can make the physicochemical property of medicine, biological activity changes, activity obviously strengthens.
Embodiment 2:
The present embodiment prepares nano ganoderma micropowder, specifically comprises the following steps:
(1) Ganoderma medical material to be processed is carried out section to pulverize, then, be placed in freezer dryer, carry out lyophilization, the Ganoderma dry powder of obtained moisture < 1%;
(2) the Ganoderma dry powder that step (1) is obtained is placed in totally enclosed type high speed centrifugation ultrafine crusher, carry out superfine grinding, gasification electrostatic separator is adopted to reclaim the Ganoderma fine powder of particle diameter < 100nm, and superfine grinding is carried out in the Ganoderma fine powder continuation circulation of particle diameter >=100nm, until the whole superfine grinding of Ganoderma dry powder is to particle diameter < 100nm, i.e. obtained nano ganoderma micropowder.
Wherein, in step (1), the particle diameter of Ganoderma dry powder is 60 orders, and cryodesiccated condition is: be first cooled to-16 DEG C rapidly by room temperature, freezing 2h, be more slowly warming up to 25 DEG C, and regulate vacuum to be 8Pa, process 2h.In practical operation, controlling rate of temperature fall is 15 DEG C/min, and controlling heating rate is 1.2 DEG C/min.
In step (2), the condition of superfine grinding is: the temperature controlling condensation cycle water is 4 DEG C, and adjustment centrifugal rotational speed is 4000rpm, and the processing time is 10min.
Embodiment 3:
The present embodiment prepares nano ganoderma micropowder, specifically comprises the following steps:
(1) Ganoderma medical material to be processed is carried out section to pulverize, then, be placed in freezer dryer, carry out lyophilization, the Ganoderma dry powder of obtained moisture < 1%;
(2) the Ganoderma dry powder that step (1) is obtained is placed in totally enclosed type high speed centrifugation ultrafine crusher, carry out superfine grinding, gasification electrostatic separator is adopted to reclaim the Ganoderma fine powder of particle diameter < 100nm, and superfine grinding is carried out in the Ganoderma fine powder continuation circulation of particle diameter >=100nm, until the whole superfine grinding of Ganoderma dry powder is to particle diameter < 100nm, i.e. obtained nano ganoderma micropowder.
Wherein, in step (1), the particle diameter of Ganoderma dry powder is 70 orders, and cryodesiccated condition is: be first cooled to-20 DEG C rapidly by room temperature, freezing 2h, be more slowly warming up to 20 DEG C, and regulate vacuum to be 10Pa, process 2h.In practical operation, controlling rate of temperature fall is 12 DEG C/min, and controlling heating rate is 2 DEG C/min.
In step (2), the condition of superfine grinding is: the temperature controlling condensation cycle water is 0 DEG C, and adjustment centrifugal rotational speed is 3500rpm, and the processing time is 12min.
Embodiment 4:
The present embodiment prepares nanometer Radix Rhodiolae micropowder, specifically comprises the following steps:
(1) Radix Rhodiolae medical material to be processed is carried out section to pulverize, then, be placed in freezer dryer, carry out lyophilization, the Radix Rhodiolae dry powder of obtained moisture < 1%;
(2) the Radix Rhodiolae dry powder that step (1) is obtained is placed in totally enclosed type high speed centrifugation ultrafine crusher, carry out superfine grinding, gasification electrostatic separator is adopted to reclaim the Radix Rhodiolae fine powder of particle diameter < 100nm, and superfine grinding is carried out in the Radix Rhodiolae fine powder continuation circulation of particle diameter >=100nm, until the whole superfine grinding of Radix Rhodiolae dry powder is to particle diameter < 100nm, i.e. obtained nanometer Radix Rhodiolae micropowder.
Wherein, in step (1), the particle diameter of Radix Rhodiolae dry powder is 80 orders, and cryodesiccated condition is: be first cooled to-22 DEG C rapidly by room temperature, freezing 3h, be more slowly warming up to 24 DEG C, and regulate vacuum to be 16Pa, process 3h.In practical operation, controlling rate of temperature fall is 15 DEG C/min, and controlling heating rate is 2.4 DEG C/min.
In step (2), the condition of superfine grinding is: the temperature controlling condensation cycle water is 2 DEG C, and adjustment centrifugal rotational speed is 3200rpm, and the processing time is 15min.
Embodiment 5:
The present embodiment prepares nanometer Cordyceps micropowder, specifically comprises the following steps:
(1) Cordyceps medical material to be processed is carried out section to pulverize, then, be placed in freezer dryer, carry out lyophilization, the Cordyceps dry powder of obtained moisture < 1%;
(2) the Cordyceps dry powder that step (1) is obtained is placed in totally enclosed type high speed centrifugation ultrafine crusher, carry out superfine grinding, gasification electrostatic separator is adopted to reclaim the Cordyceps fine powder of particle diameter < 100nm, and superfine grinding is carried out in the Cordyceps fine powder continuation circulation of particle diameter >=100nm, until the whole superfine grinding of Cordyceps dry powder is to particle diameter < 100nm, i.e. obtained nanometer Cordyceps micropowder.
Wherein, in step (1), the particle diameter of Cordyceps dry powder is 60 orders, and cryodesiccated condition is: be first cooled to-18 DEG C rapidly by room temperature, freezing 2.5h, be more slowly warming up to 22 DEG C, and regulate vacuum to be 12Pa, process 2.5h.In practical operation, controlling rate of temperature fall is 10 DEG C/min, and controlling heating rate is 2 DEG C/min.
In step (2), the condition of superfine grinding is: the temperature controlling condensation cycle water is 0 DEG C, and adjustment centrifugal rotational speed is 3000rpm, and the processing time is 15min.
Claims (6)
1. a preparation method for nanometer Chinese herbal medicine micropowder, is characterized in that, the method specifically comprises the following steps:
(1) Chinese medicinal herbs to be processed is carried out section to pulverize, then, be placed in freezer dryer, carry out lyophilization, the Chinese herbal medicine dry powder of obtained moisture < 1%;
(2) the Chinese herbal medicine dry powder that step (1) is obtained is placed in totally enclosed type high speed centrifugation ultrafine crusher, carry out superfine grinding, gasification electrostatic separator is adopted to reclaim the Chinese herbal medicine fine powder of particle diameter < 100nm, and superfine grinding is carried out in the Chinese herbal medicine fine powder continuation circulation of particle diameter >=100nm, until the whole superfine grinding of Chinese herbal medicine dry powder is to particle diameter < 100nm, i.e. obtained nanometer Chinese herbal medicine micropowder.
2. the preparation method of a kind of nanometer Chinese herbal medicine micropowder according to claim 1, is characterized in that, the particle diameter of the Chinese herbal medicine dry powder described in step (1) is 60-80 order.
3. the preparation method of a kind of nanometer Chinese herbal medicine micropowder according to claim 1, it is characterized in that, cryodesiccated condition described in step (1) is: be first cooled to rapidly-16 ~-22 DEG C by room temperature, freezing 2 ~ 3h, slowly be warming up to 20 ~ 25 DEG C again, and regulate vacuum to be 8 ~ 16Pa, process 2 ~ 3h.
4. the preparation method of a kind of nanometer Chinese herbal medicine micropowder according to claim 3, it is characterized in that, described rate of temperature fall is 10 ~ 15 DEG C/min.
5. the preparation method of a kind of nanometer Chinese herbal medicine micropowder according to claim 3, it is characterized in that, described heating rate is 1.2 ~ 2.4 DEG C/min.
6. the preparation method of a kind of nanometer Chinese herbal medicine micropowder according to claim 1, it is characterized in that, the condition of the superfine grinding described in step (2) is: the temperature controlling condensation cycle water is 0 ~ 4 DEG C, adjustment centrifugal rotational speed is 3000 ~ 4000rpm, and the processing time is 10 ~ 15min.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109954012A (en) * | 2017-12-25 | 2019-07-02 | 深圳市华力康生物科技有限公司 | A kind of Chinese medicine nanometer powder solid composite and preparation method thereof |
| CN110250434A (en) * | 2019-05-27 | 2019-09-20 | 黑龙江省北大荒绿色健康食品有限责任公司 | A kind of preparation method of high natural protein content bean powder |
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| CN1544080A (en) * | 2003-11-21 | 2004-11-10 | 钱康南 | Preparation and application of nanometer chrysalid worm grass meal |
| CN1586528A (en) * | 2004-08-13 | 2005-03-02 | 武汉理工大学 | Method for nano plant Chinese medicine |
| CN103229994A (en) * | 2013-04-19 | 2013-08-07 | 上海亨利生物医药科技有限公司 | Preparation method of nano cordyceps militaris powder for improving bioavailability of cordycepin, polysaccharide and adenosine |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1544080A (en) * | 2003-11-21 | 2004-11-10 | 钱康南 | Preparation and application of nanometer chrysalid worm grass meal |
| CN1586528A (en) * | 2004-08-13 | 2005-03-02 | 武汉理工大学 | Method for nano plant Chinese medicine |
| CN103229994A (en) * | 2013-04-19 | 2013-08-07 | 上海亨利生物医药科技有限公司 | Preparation method of nano cordyceps militaris powder for improving bioavailability of cordycepin, polysaccharide and adenosine |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109954012A (en) * | 2017-12-25 | 2019-07-02 | 深圳市华力康生物科技有限公司 | A kind of Chinese medicine nanometer powder solid composite and preparation method thereof |
| CN110250434A (en) * | 2019-05-27 | 2019-09-20 | 黑龙江省北大荒绿色健康食品有限责任公司 | A kind of preparation method of high natural protein content bean powder |
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