CN108813581A - 一种保肝解酒组合物及其制备方法 - Google Patents
一种保肝解酒组合物及其制备方法 Download PDFInfo
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- CN108813581A CN108813581A CN201810481781.9A CN201810481781A CN108813581A CN 108813581 A CN108813581 A CN 108813581A CN 201810481781 A CN201810481781 A CN 201810481781A CN 108813581 A CN108813581 A CN 108813581A
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Abstract
本发明公开了一种保肝解酒组合物及其制备方法，该组合物由重量份的绿豆肽1‑10份、玉米肽0.1‑5份、低聚异麦芽糖0.1‑5份、膳食纤维0.1‑5份、绿咖啡豆提取物0.1‑5份、金银花提取物0.1‑5份、低聚木糖0.1‑5份、甘草提取物0.01‑5份、罗汉果苷0.01‑5份、牛磺酸0.01‑1份混合制成。本发明保肝解酒组合物口感甜润，药效作用明显，不仅能起到保肝解酒作用，增加饮酒者酒量上限，消除醒酒时头痛、头晕等宿醉症状，还能改善肠道菌群组成结构，具有良好的保健作用。
Description
技术领域
本发明属于保健品技术领域，尤其涉及一种保肝解酒组合物及其制备方法。
背景技术
酒文化是中华民族饮食文化的重要组成部分，已成为人们社会活动不可缺少的工具。人体饮酒后，酒精自肠胃道吸收迅速进入血液，在2小时内被完全吸收，其中，约80％酒精被十二指肠和空肠吸收，其余的20％由胃吸收，人体吸收的酒精快速分布至全身各组织，适量者有助于身体健康，过量者轻则引起昏睡以及各种无意识行为，重则甚至引起酒精中毒死亡。肝脏是代谢酒精的主要器官，酒精经肝脏中的乙醇脱氢酶(ADH)催化生产乙醛，乙醛经肝线粒体中的乙醛脱氢酶(ALDH)进一步氧化成无毒乙酸，最终生成二氧化碳和能量。但肝脏代谢酒精速度缓慢，且酒精具有细胞毒性，一次过量饮酒导致肝脏难以快速代谢，酒精累积肝脏会使肝细胞膜表面的脂质过氧化，破坏肝细胞膜，进一步发展会使肝细胞内的微管和线粒体等结构受到破坏，使细胞内的代谢紊乱，导致具有细胞毒性的代谢产物产生，从而导致肝细胞肿胀、坏死。
现今，受酒桌文化的影响，许多人饮酒过度，超出人体酒精代谢的限度，从而引起肝脏损伤和肝脏功能衰退，对人体的健康构成了极大的威胁。目前的保肝解酒产品有西药和保健产品，其中，西药在短期内有良好的作用，但是无法对人体进行系统的治疗和调养，同时具有很大的副作用。而保健产品含有一定量的功效成分，能够调节人体的机能，维护健康或预防某种疾病，安全无毒，受益人群广；随着消费者健康和安全意识的逐渐增强，保健品具有广阔的市场前景。
肠道菌群的组成不仅受环境影响，亦与遗传背景、宿主及菌群间的相互作用相关，而个体化菌群变化会引起肥胖、糖尿病、脂肪肝、高脂肪症等疾病，而这些疾病的发生是肝脏疾病进展的威胁因素，且随着研究的深入和积累，肠道菌群与肝损伤之间的关系逐渐明确。最引人注目的是，研究发现乙醇的代谢产物乙醛对肝脏的损伤远高于乙醇，而且乙醇脱氢酶和乙醛脱氢酶的活性与肠道菌群之间有密切联系，比如肠道菌群中变形杆菌数量与乙醛蓄积量成正相关，而且变形杆菌数量不仅能够增加内源性酒精的产生，还能影响酒精代谢。
鉴于此，专利申请公布号CN 106616107 A公开了一种解酒、保健、补充能量的饮料，其由膳食纤维、木质素、椴树蜜、牛磺酸、浓缩草莓汁、葡萄糖、柠檬汁、木酚素、卵磷脂、大豆低聚糖、维生素C、维生素B1、维生素B6、谷胱甘肽、聚甘油脂肪酸酯、嗜热链球菌、嗜酸乳杆菌、双歧杆菌、乳酸乳球菌乳酸亚种、乳酸乳球菌乳脂亚种、乳酸乳球菌双乙酰亚种混合制成。该饮料可对体内酒精进行有效降解，使醉酒人们迅速恢复清醒，还具有降低血脂、血糖、血压并提高酶活性的作用，以及增强合成DNA、RNA、蛋白质的能力，促进细胞及组织活化，维持生理平衡、提高机体抵抗能力。但由于该饮料中加入嗜热链球菌、嗜酸乳杆菌、双歧杆菌等多种外源性肠道菌，使得外源性菌群与肠道内原有菌群难以快速融合并达到平衡，从而无法从根本上激发肝脏内乙醇脱氢酶和乙醛脱氢酶的活性，以至人体对该饮料产生一定的依赖性。
发明内容
本发明的目的在于：提供一种保肝解酒组合物及其制备方法，该组合物由绿豆肽、低聚异麦芽糖、绿咖啡豆提取物、甘草提取物、罗汉果苷和牛磺酸等混合而成，不仅能够抑制变形杆菌等有害菌，增殖体内益生菌，还能与肝脏中乙醇代谢产物乙醛结合，从而达到降解体内乙醛的目的，降低乙醛对肝脏和肝脏功能的损伤。
为了实现上述目的，本发明采用如下技术方案：
一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽1-10份、玉米肽0.1-5份、低聚异麦芽糖0.1-5份、膳食纤维0.1-5份、绿咖啡豆提取物0.1-5份、金银花提取物0.1-5份、低聚木糖0.1-5份、甘草提取物0.01-5份、罗汉果苷0.01-5份、牛磺酸0.01-1份。
作为优选，所述的一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽3-10份、玉米肽0.5-5份、低聚异麦芽糖0.5-5份、膳食纤维0.5-5份、绿咖啡豆提取物0.5-5份、金银花提取物0.5-5份、低聚木糖0.5-5份、甘草提取物0.05-5份、罗汉果苷0.05-5份、牛磺酸0.05-1份。
作为进一步优选，所述的一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽5-10份、玉米肽2-5份、低聚异麦芽糖1.5-5份、膳食纤维2.5-5份、绿咖啡豆提取物1-5份、金银花提取物1.5-5份、低聚木糖1.5-5份、甘草提取物0.2-5份、罗汉果苷0.2-5份、牛磺酸0.08-1份。
作为更进一步优选，所述的一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽8份、玉米肽3份、低聚异麦芽糖2份、膳食纤维3份、绿咖啡豆提取物1.5份、金银花提取物2份、低聚木糖2份、甘草提取物0.5份、罗汉果苷1份、牛磺酸0.08份。
进一步，将所述保肝解酒组合物制备成压片糖果、口香糖或液体饮料。
更进一步，所述保肝解酒组合物制备成压片糖果，包括如下步骤：
1)按照上述配方称取各组分，混合得到组分混合物；
2)将所述组分混合物经过配料、压片、定型、干燥、灭菌、包装、检验、外包装工艺后，制成压片糖果。
与现有技术相比，本发明的有益效果在于：
1)本发明保肝解酒组合物精选绿豆肽、绿咖啡豆提取物、低聚木糖、罗汉果苷等10种原料配伍，其配比科学合理，其中以绿咖啡豆提取物、金银花提取物和甘草提取物协同抑制变形杆菌等有害菌，其有效率提升18.7％左右；以低聚木糖、水溶性膳食纤维和低聚异麦芽糖协同增殖体内益生菌，其有效率提升15.5％左右；以绿豆肽、玉米肽作为主要功能成分，两者均可与乙醛结合使其降解，从而减少乙醛对人体的损伤，达到保肝解酒的目的；
2)本发明保肝解酒组合物中还加入牛磺酸，其不仅能优化肠道内菌群结构，还能显著提高肝脏中乙醇脱氢酶和乙醛脱氢酶的活性，起到解酒防醉效果；加入罗汉果苷不仅作为甜味剂使用，改善组合物产品的适口性，还能起到保肝及润肠作用，对改善肠道菌群结构具有显著作用；
3)本发明保肝解酒组合物口感甜润，药效作用明显，不仅能起到保肝解酒作用，而且能够改善肠道菌群组成结构，具有良好的保健作用；
4)本发明保肝解酒组合物不仅能够起到解酒作用，还能起到改善喝酒时味感的作用，消除白酒辛辣味，更重要的是，长期食用或饮用本发明组合物产品能够增加酒量，酒量增幅达35％左右。
具体实施方式
下面结合具体实施例对本发明的技术方案作进一步说明，以便于同领域技术人员的理解，但不限制本发明的权利范围。
实施例1
一种保肝解酒组合物，由如下重量份原料制成：绿豆肽8kg、玉米肽3kg、低聚异麦芽糖2kg、膳食纤维3kg、绿咖啡豆提取物1.5kg、金银花提取物2kg、低聚木糖2kg、甘草提取物0.5kg、罗汉果苷1kg、牛磺酸0.08kg；
按照上述配比，将所述保肝解酒组合物制备成压片糖果、口香糖或液体饮料中任意一种产品类型，如压片糖果，制备工艺包括如下：
1)按照上述配方称取各组分，混合得到组分混合物；
2)将所述组分混合物经过配料、压片、定型、干燥、灭菌、包装、检验、外包装工艺后，制成压片糖果。
实施例2
一种保肝解酒组合物，根据需求可制备成压片糖果、口香糖或液体饮料以及其他产品类型，原料配比如下：
绿豆肽1kg、玉米肽0.1kg、低聚异麦芽糖0.1kg、膳食纤维0.1kg、绿咖啡豆提取物0.1kg、金银花提取物0.1kg、低聚木糖0.1kg、甘草提取物0.01kg、罗汉果苷0.01kg、牛磺酸0.01kg。
实施例3
一种保肝解酒组合物，根据需求可制备成压片糖果、口香糖或液体饮料以及其他产品类型，原料配比如下：
绿豆肽3kg、玉米肽0.5kg、低聚异麦芽糖0.5kg、膳食纤维0.5kg、绿咖啡豆提取物0.5kg、金银花提取物0.5kg、低聚木糖0.5kg、甘草提取物0.05kg、罗汉果苷0.05kg、牛磺酸0.05kg。
实施例4
一种保肝解酒组合物，根据需求可制备成压片糖果、口香糖或液体饮料以及其他产品类型，原料配比如下：
绿豆肽5kg、玉米肽2kg、低聚异麦芽糖1.5kg、膳食纤维2.5kg、绿咖啡豆提取物1kg、金银花提取物1.5kg、低聚木糖1.5kg、甘草提取物0.2kg、罗汉果苷0.2kg、牛磺酸0.08kg。
实施例5
一种保肝解酒组合物，根据需求可制备成压片糖果、口香糖或液体饮料以及其他产品类型，原料配比如下：
绿豆肽10kg、玉米肽5kg、低聚异麦芽糖5kg、膳食纤维5kg、绿咖啡豆提取物5kg、金银花提取物5kg、低聚木糖5kg、甘草提取物5kg、罗汉果苷5kg、牛磺酸1kg。
下面结合典型案例资料予以说明本发明保肝解酒组合物的功效：
1、志愿者甲：无白酒饮用史，对白酒辛辣味十分敏感，无法下咽，诸如茅台、五粮液等品牌名酒都十分抵触，服用本发明保肝解酒组合物产品5天(50g)后，喝茅台酒时感觉辛辣味明显减轻，有淡淡酒香味，饮酒200ml，无醉酒症状，仅谈话表现略有增加。
2、志愿者乙：平时酒量限制500ml，且饮酒至醉酒状态，第2天酒醒仍然有头疼、头晕等宿醉症状，服用本发明保肝解酒组合物产品后，饮酒至醉酒状态，第2天酒醒后无任何头疼、头晕等宿醉症状。
3、志愿者丙：平时酒量限制450ml，服用本发明保肝解酒组合物产品后，酒量限制提高至550ml，且无明显醉酒症状，也未出现身体不适感。
通过以上典型案例资料可知，本发明保肝解酒组合物产品具有增加酒量限制，消除酒醒时伴随的头晕、头痛等宿醉症状的效果，也可改善承受白酒辛辣味者饮酒时的酒味感。
需要注意的是，凡是将本发明组合物成分替换成提取原料的任意组合的技术方案均属于本发明的保护范围。
Claims (6)
1.一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽1-10份、玉米肽0.1-5份、低聚异麦芽糖0.1-5份、膳食纤维0.1-5份、绿咖啡豆提取物0.1-5份、金银花提取物0.1-5份、低聚木糖0.1-5份、甘草提取物0.01-5份、罗汉果苷0.01-5份、牛磺酸0.01-1份。
2.如权利要求1所述的一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽3-10份、玉米肽0.5-5份、低聚异麦芽糖0.5-5份、膳食纤维0.5-5份、绿咖啡豆提取物0.5-5份、金银花提取物0.5-5份、低聚木糖0.5-5份、甘草提取物0.05-5份、罗汉果苷0.05-5份、牛磺酸0.05-1份。
3.如权利要求1或2所述的一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽5-10份、玉米肽2-5份、低聚异麦芽糖1.5-5份、膳食纤维2.5-5份、绿咖啡豆提取物1-5份、金银花提取物1.5-5份、低聚木糖1.5-5份、甘草提取物0.2-5份、罗汉果苷0.2-5份、牛磺酸0.08-1份。
4.如权利要求1-3任意一项所述的一种保肝解酒组合物，其特征在于：由如下重量份原料制成：绿豆肽8份、玉米肽3份、低聚异麦芽糖2份、膳食纤维3份、绿咖啡豆提取物1.5份、金银花提取物2份、低聚木糖2份、甘草提取物0.5份、罗汉果苷1份、牛磺酸0.08份。
5.如权利要求1-4任意一项所述的一种保肝解酒组合物，其特征在于：将所述保肝解酒组合物制备成压片糖果、口香糖或液体饮料。
6.如权利要求5所述的一种保肝解酒组合物，其特征在于：将所述保肝解酒组合物制备成压片糖果，包括如下步骤：
1)按照上述配方称取各组分，混合得到组分混合物；
2)将所述组分混合物经过配料、压片、定型、干燥、灭菌、包装、检验、外包装工艺后，制成压片糖果。
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| CN113318118A (zh) * | 2021-06-21 | 2021-08-31 | 广西大学 | 罗汉果甜苷提取物在热应激肠道损伤中的应用 |
| CN113519737A (zh) * | 2021-03-24 | 2021-10-22 | 苏州东诚堂生物科技有限公司 | 一种解酒护肝的多肽饮品及其制备方法 |
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| CN110946280A (zh) * | 2019-12-09 | 2020-04-03 | 董金龙 | 一种解酒护肝健脑的*酒肽及解酒护肝健脑*酒肽保健食品 |
| CN112970889A (zh) * | 2021-02-25 | 2021-06-18 | 广东维尔嘉康生命科技有限公司 | 一种具有防醉醒酒功能的小分子肽组合物 |
| CN113519737A (zh) * | 2021-03-24 | 2021-10-22 | 苏州东诚堂生物科技有限公司 | 一种解酒护肝的多肽饮品及其制备方法 |
| CN113318118A (zh) * | 2021-06-21 | 2021-08-31 | 广西大学 | 罗汉果甜苷提取物在热应激肠道损伤中的应用 |
| CN113318118B (zh) * | 2021-06-21 | 2022-11-25 | 广西大学 | 罗汉果甜苷提取物在热应激肠道损伤中的应用 |
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