CN108794411B - 某些化学实体、组合物及方法 - Google Patents

某些化学实体、组合物及方法 Download PDF

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Publication number
CN108794411B
CN108794411B CN201810724450.3A CN201810724450A CN108794411B CN 108794411 B CN108794411 B CN 108794411B CN 201810724450 A CN201810724450 A CN 201810724450A CN 108794411 B CN108794411 B CN 108794411B
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carbonyl
phenyl
optionally substituted
quinoxaline
urea
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Chinese (zh)
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CN108794411A (zh
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向平·钱
永-亮·朱
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Neupharma Inc
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Neupharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201810724450.3A 2011-09-14 2012-09-14 某些化学实体、组合物及方法 Active CN108794411B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161534390P 2011-09-14 2011-09-14
US61/534,390 2011-09-14
US201161535992P 2011-09-18 2011-09-18
US61/535,992 2011-09-18
CN201280055629.5A CN104080455B (zh) 2011-09-14 2012-09-14 某些化学实体、组合物及方法
PCT/US2012/055653 WO2013040515A1 (en) 2011-09-14 2012-09-14 Certain chemical entities, compositions, and methods

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CN108794411A CN108794411A (zh) 2018-11-13
CN108794411B true CN108794411B (zh) 2022-06-07

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CN202210707660.8A Pending CN115403531A (zh) 2011-09-14 2012-09-14 作为激酶抑制剂的化学实体、组合物及方法
CN201280055629.5A Active CN104080455B (zh) 2011-09-14 2012-09-14 某些化学实体、组合物及方法

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CN201280055629.5A Active CN104080455B (zh) 2011-09-14 2012-09-14 某些化学实体、组合物及方法

Country Status (7)

Country Link
US (6) US9518029B2 (enExample)
EP (2) EP3332785B1 (enExample)
JP (2) JP6093768B2 (enExample)
CN (3) CN108794411B (enExample)
AU (2) AU2012308238B2 (enExample)
CA (1) CA2848506C (enExample)
WO (1) WO2013040515A1 (enExample)

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EP3332785A1 (en) 2018-06-13
CA2848506A1 (en) 2013-03-21
AU2012308238A1 (en) 2014-04-17
CN108794411A (zh) 2018-11-13
US20180134669A1 (en) 2018-05-17
US20220251049A1 (en) 2022-08-11
CN104080455A (zh) 2014-10-01
CN104080455B (zh) 2018-07-31
US10065932B2 (en) 2018-09-04
US9822081B2 (en) 2017-11-21
CA2848506C (en) 2020-07-21
AU2017218983A1 (en) 2017-09-07
WO2013040515A1 (en) 2013-03-21
JP2017082011A (ja) 2017-05-18
JP6093768B2 (ja) 2017-03-08
CN115403531A (zh) 2022-11-29
JP2014530194A (ja) 2014-11-17
EP2755657A4 (en) 2015-03-25
AU2017218983B2 (en) 2019-05-02
EP2755657B1 (en) 2017-11-29
US10759766B2 (en) 2020-09-01
AU2012308238B2 (en) 2017-05-25
EP3332785B1 (en) 2020-05-06
US20200055828A1 (en) 2020-02-20
EP2755657A1 (en) 2014-07-23
US20210040048A1 (en) 2021-02-11
US20170183316A1 (en) 2017-06-29
US9518029B2 (en) 2016-12-13
US20150158826A1 (en) 2015-06-11

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