CN108785567A - A kind of drug and preparation method thereof for treating tuberculous osteoarthropathy - Google Patents

A kind of drug and preparation method thereof for treating tuberculous osteoarthropathy Download PDF

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CN108785567A
CN108785567A CN201810927656.6A CN201810927656A CN108785567A CN 108785567 A CN108785567 A CN 108785567A CN 201810927656 A CN201810927656 A CN 201810927656A CN 108785567 A CN108785567 A CN 108785567A
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grams
impurity
dries
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root
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陈怀银
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract

The invention discloses a kind of drugs and preparation method thereof for treating tuberculous osteoarthropathy, it is mainly by ground bettle, tortoise plastron, long-noded pit viper, honeysuckle, prepared rehmannia root, dragon's blood, teasel root, zaocys dhumnade, the root of bidentate achyranthes, oyster, scorpio, the rhizome of davallia, Semen Cuscutae, rhizoma cibotii, deer horn glue, cicada slough, Radix Notoginseng, frankincense, myrrh, the fruit of glossy privet, bletilla, moutan bark, coix seed, Prunella vulgaris, seaweed, corydalis tuber, carbonized hair, radix bupleuri is prepared according to a certain weight ratio, drug of the present invention has broken stasis of blood blood, nourishing and suppressing Yang, it is clearing heat and detoxicating, filling liver kidney, benefiting quintessence, the function of tonifying lung, it is quick for treating tuberculous osteoarthropathy, good effect, it does not recur.

Description

A kind of drug and preparation method thereof for treating tuberculous osteoarthropathy
Technical field
The present invention relates to a kind of drugs and preparation method thereof for treating tuberculous osteoarthropathy, belong to the field of Chinese medicines.
Technical background
Tuberculous osteoarthropathy is the destructive lesion as caused by tubercle bacillus invades bone or joint.Site of pathological change majority is negative Great, movable bones that are more, being easy to happen strain or joint.Most predilection site is backbone, followed by hip, knee, foot, elbow, hand etc..In Doctor then thinks tuberculous osteoarthropathy and caused by liver and kidney deficiency, damage and exhaustion of lung-YIN, fire excess from yin deficiency, obstruction of collaterals by blood stasis is related.Since western medicine pair is made With big, therefore there are great demands to the Chinese medicine of effectively treating tuberculous osteoarthropathy by people, up to now, it has not been found that Related report about the present invention.
Invention content
Repeatedly verification of the present inventor according to research and the clinical test of theory of traditional Chinese medical science has finally found effectively treatment bone and closes The drug of nodule core, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine compositions of effective treatment tuberculous osteoarthropathy.
Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.
The present invention is selection ground bettle, tortoise plastron, long-noded pit viper, honeysuckle, prepared rehmannia root, dragon's blood, teasel root, zaocys dhumnade, the root of bidentate achyranthes, male Oyster, scorpio, the rhizome of davallia, Semen Cuscutae, rhizoma cibotii, deer horn glue, cicada slough, Radix Notoginseng, frankincense, myrrh, the fruit of glossy privet, bletilla, moutan bark, Job's tears Benevolence, Prunella vulgaris, seaweed, corydalis tuber, carbonized hair, radix bupleuri, Radix Paeoniae Alba, safflower, Cortex Phellodendri, Chinese violet, kelp drug are combined system Standby, make each efficacy of drugs generate synergistic effect these pharmaceutical compositions, so as to effectively treat tuberculous osteoarthropathy.Wherein It is because its nature and flavor is salty, cold to select ground bettle, and slightly poisonous, return liver warp has broken stasis of blood blood, the function of continuous muscles and bones to control injured bone, the stasis of blood Blood Amenorrhea , abdominal mass and lump.It is to enter liver and kidney channel because of the salty sweet and neutral of its nature and flavor to select tortoise plastron, there is an enriching yin, checking exuberance of yang, kidney tonifying, strong bone Function controls the deficiency of the kidney yin, and hectic fever due to yin labor heat is spitted blood, bleeding from five sense organs or subcutaneous tissue, chronic cough, seminal emission, uterine bleeding, under band, pain in the back, and the atrophic debility of bones, wind formation from yin deficiency, long Dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.It is because its nature and flavor is sweet, salty to select long-noded pit viper, and temperature, toxic, return liver warp has wind-dispelling Wet, saturating muscles and bones, arresting convulsion is jerked.It controls rheumatism to paralyse, arthralgia, leprosy, scabies leprosy, child convulsion is twitched, lockjaw, syphilis, scrofula Scrofula malignant sore.It is to tremble with fear because its nature and flavor is sweet, enter lung, stomach, have heat-clearing, the function of removing toxic substances to control warm disease heating to select honeysuckle, heat Malicious bloody flux, large carbuncle, pyogenic infections, scrofula, anal fistula.It is because its nature and flavor is sweet to select prepared rehmannia root, and tepor enters liver and kidney channel, there is enriching yin, is mended The function of blood, it is few to control deficiency of Yin blood, waist knee flaccidity, Cough osteopyrexia, and seminal emission, uterine bleeding, irregular menstruation is quenched one's thirst, number of urinating, deaf, blurred vision. It is to put down because of its property sweet-salty, enter the heart, Liver Channel, have scattered stasis pain, the function of hemostasia and promoting granulation to control traumatic injury to select dragon's blood, interior Hinder stasis caused pain, traumatic hemorrhage is more than, scrofula, and ulcer on the shank is burst not to be conformed to long.It is because of its nature and flavor toil to select teasel root, and tepor enters liver, kidney Through, there are filling liver kidney, continuous muscles and bones to adjust the function of blood vessels, controls aching pain in waist and back, the foot and knee being feeble, threatened abortion, uterine bleeding, under band, seminal emission, bruise Damage, metal-inflicted wound, anal fistula, ulcer sore swells.It is because of its nature and flavor sweet and neutral to select zaocys dhumnade, and return liver warp has dispelling, collateral-activating, antispastic to control Arthralgia pain due to rheumatism, numb limb, spasm of twitching, pruitus, leprosy.Select the root of bidentate achyranthes and be because its nature and flavor sweetness and bitterness acid, puts down, enter liver, Kidney channel, life scattered blood stasis, the function of subduing inflammation control gonorrhoea, hematuria, Amenorrhea , Disorder lumps in the abdomen, difficult labour, placenta retension, postpartum blood stasis abdomen Bitterly, larynx numbness, carbuncle swells, traumatic injury are ripe that filling liver kidney, strengthening the bones and muscles is used to control control waist and knee ostalgia, spasm of limbs, Impotence numbness.Select oyster be because It is salty and bitter for its nature and flavor, it is cool, enter liver and kidney channel, holds back the moon, checking exuberance of yang, hidroschesis, the function of puckery essence, Zhi Jing Epilepsy, dizziness, spontaneous perspiration, night sweat, Seminal emission, stranguria with turbid discharge, uterine bleeding, under, scrofula, goiter and tumor.Selecting scorpio is put down because its nature and flavor is salty pungent, toxic, enters meridian of Foot-JUE YIN, has Wind-dispelling, relieving convulsion, dredging collateral, the function of removing toxic substances control convulsion , Dian Epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, rheumatism Numbness pain, lockjaw, scrofula, rubella sore swells.It is because its is bitter in taste to select the rhizome of davallia, and temperature enters liver and kidney channel, there is kidney tonifying, Promoting blood circulation, the function of hemostasis control kidney deficiency chronic diarrhea and pain in the back, arthralgia pain due to rheumatism, dentalgia, tinnitus, the bruise sudden strain of a muscle, bone fracture, appendicitis, spot It is bald, corn.It is to enter liver and kidney channel because of the pungent sweet and neutral of its nature and flavor, have filling liver kidney, benefiting quintessence, the function of improving eyesight to control to select Semen Cuscutae Soreness of waist and knee joint, seminal emission, quenches one's thirst, dripping urination, and mesh is dark.It is to enter liver and kidney channel because of its sweet, warm bitter in taste, there is tonifying liver to select rhizoma cibotii Kidney, curing rheumatism are good for waist foot, and the function in sharp joint controls back ache, goinyalgia flaccidity of lower limbs, and cold-dampness general arthralgia loses and drowns, frequent micturition, seminal emission, in vain Band.It is because of its property sweet-salty to select deer horn glue, and temperature enters liver and kidney channel, enriches blood, the function of strengthening the essence controls deficiency of kidney-QI, consumptive disease Thin thin, pain in the back, cloudy subcutaneous ulcer, impotence in male, involuntary emission, uterus void is cold, uterine bleeding, under band.Select cicada slough be because of its property sweet-salty, It is cool, enter lung, Liver Channel, there is dissipate wind-heat, facilitaing lung to determine the function of convulsion, controls affection of exogenous wind-heat, hoarse voice of coughing, measles without adequate eruption, rubella scabies Itch, little Jing Epilepsy, hot eyes, ocular, furuncle swelling toxin, lockjaw.It is the temperature because of its property sweet and slightly bitter taste to select Radix Notoginseng, enter liver, stomach, Large intestine channel has hemostasis, dissipates the stasis of blood, detumescence, and the function of analgesic therapy controls haematemesis, hemoptysis, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, bloody flux, uterine bleeding , Disorder lumps in the abdomen, postpartum Bruise, lochia not under, fall and flutter hemostasis, traumatic hemorrhage, carbuncle swells pain.It is the temperature because its nature and flavor is arduous to select frankincense, enter the heart, liver, The spleen channel has regulating qi and activating blood, analgesic therapy, the function of chasing after poison to control qi and blood stagnation, trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhoea, production Hemostasis shouting pain afterwards.It is to put down because its is bitter in taste, enter Liver Channel, have scattered blood stasis eliminatings, the function of detumescence ding-tong to control and fall damage to select myrrh, Metal-inflicted wound, muscles and bones, all Tong , Disorder lumps in the abdomen of trusted subordinate, Amenorrhea, ulcer sore pain, anal fistula, mesh barrier.Select the fruit of glossy privet be because of its nature and flavor bitter sweet, It is flat, enter liver and kidney channel, there is filling liver kidney, the function of strong waist and knee to control yin asthenia generating intrinsic heat, dizzy, mesh spends tinnitus, soreness and weakness of waist and knees, beard and hair morning In vain.Select bletilla be because of its nature and flavor bitter sweet, it is cool, enter lung channel, there is tonifying lung, stop blooding, detumescence is raw to see, the function of sore, controls lung wound Hemoptysis, bleeding from five sense organs or subcutaneous tissue, metal-inflicted wound bleeding, swollen ulcer drug, canker sores, soup fire burn, rhagadia manus et pedis.It is because of its nature and flavor to select moutan bark It is arduous, it is cool, enter the heart, liver and kidney channel, there is heat-clearing, cool blood and blood, the function of dispersing blood stasis controls heat invading xuefen, macular eruption , Jing Epilepsy, spit, be defeated in battle, It has blood in stool, hectic fever due to yin labor heat, Amenorrhea , Disorder lumps in the abdomen, large carbuncle flutters damage.Select coix seed be because of its property slightly sweet flavor, it is cool, enter spleen, lung, kidney channel, There is an invigorating the spleen, tonifying lung, heat-clearing, the function of dampness removing controls diarrhea, arthritis with fixed pain caused by dampness, muscle arteries and veins contraction, joint stuffiness, oedema, tinea pedis, consumptive lung disease, lung Carbuncle, acute appendicitis, stranguria with turbid discharge, leukorrhea.Selecting Prunella vulgaris is trembled with fear, enters liver, gallbladder channel because of its nature and flavor toil, there is a clearing liver, the function of dissipating bind, Control scrofula, goiter and tumor, acute mastitis, breast cancer, mesh pearl nyctalgia, photophobia sheds tears, vertigo, facial paralysis, arthralgia and myalgia, and pulmonary tuberculosis is anxious Property icteric catarrhal jaundice, metrorrhagia, band under.It is to tremble with fear because its is bitter in taste salty, enter lung, spleen, kidney channel, there is softening hard masses to select seaweed, Dissolving phlegm, Li Shui, the function of expelling the heat-evil control scrofula, goiter and tumor, accumulation, oedema, tinea pedis, testiclar gall.It is because of its property to select corydalis tuber Acrid flavour is bitter, and temperature enters liver, stomach, there is promoting blood circulation, dissipates the stasis of blood, qi-regulating, the function of analgesic, controls all pains of trusted subordinate's waist and knee, irregular menstruation , Disorder lumps in the abdomen, Metrorrhagia, postpartum anemic fainting, lochiorrhagia, traumatic injury.It is because its is bitter in taste to select carbonized hair, and temperature enters the heart, liver and kidney channel, has and disappear The stasis of blood, the function of hemostasis control haematemesis, nosebleed epistaxis, gingiva bleeding gingival hemorrhage, bloody flux, blood strangury, uterine bleeding.Select radix bupleuri be because its is bitter in taste, it is cool, Enter liver, gallbladder channel, has in inducing diaphoresis, soothing the liver, the function of rising Yang controls fevers and chills alternate, and fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria Disease, lower profit rectal prolapse, irregular menstruation, metroptosis.Select Radix Paeoniae Alba be because of its nature and flavor picric acid, it is cool, enter liver, the spleen channel, have blood-nourishing soft Liver, analgesic in delaying hold back the cloudy function of receiving sweat, control chest and abdomen pain over the hypochondriac region, diarrhea dysentery abdominal pain, spontaneous sweating, fever due to yin deficiency, menstruation is not It adjusts, uterine bleeding, under band.It is to enter the heart, Liver Channel because its nature and flavor is acrid in flavour and warm in nature to select safflower, has invigorate blood circulation, the function of stasis eliminatings analgesic to control Amenorrhea , Disorder lumps in the abdomen, difficult labour, stillborn foetus, disease that postpartum lochia can't go, hemostasis are had a pain, carbuncle swells, injury from falling down.It is because of its nature and flavor to select Cortex Phellodendri Hardship trembles with fear, enters lung, stomach, kidney channel, have nourishing yin and lessening fire, the function of moisturize laxation to control dysphoria with smothery sensation and quench one's thirst, hectic fever due to yin labor heat, cough with lung heat, greatly Just constipation, difficult urination.It is the converge to heart and liver channels because of its nature and flavor bitter, acrid, cold to select Chinese violet, has clearing heat and detoxicating, and cool blood disappears Swollen function controls furuncle swelling toxin, ulcer carbuncle on the back, erysipelas, venomous snake bite.It is to tremble with fear because its nature and flavor is salty, enter stomach to select kelp, There are softening hard masses, the function of row water to control scrofula, goiter and tumor is dysphagic, oedema, testiclar gall, under band.
Specific implementation mode
The drug dose of instant component is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is following heavy All tools have a better effect in amount range
15-20 grams of ground bettle, 10-20 grams of tortoise plastron, 5-10 grams of long-noded pit viper, 10-20 grams of honeysuckle, 5-15 grams of prepared rehmannia root, dragon's blood 10- 15 grams, 10-20 grams of teasel root, 10-15 grams of zaocys dhumnade, 10-15 grams of the root of bidentate achyranthes, 10-20 grams of oyster, 3-9 grams of scorpio, rhizome of davallia 10-20 Gram, 10-15 grams of Semen Cuscutae, 10-15 grams of rhizoma cibotii, 10-20 grams of deer horn glue, 5-15 grams of cicada slough, 10-15 grams of Radix Notoginseng, 5-15 grams of frankincense, 5-15 grams of myrrh, 10-15 grams of the fruit of glossy privet, 10-20 grams of bletilla, 10-15 grams of moutan bark, 5-15 grams of coix seed, 3-9 grams of Prunella vulgaris, 5-10 grams of seaweed, 10-20 grams of corydalis tuber, 10-20 grams of carbonized hair, 5-15 grams of radix bupleuri, 10-15 grams of Radix Paeoniae Alba, 5-15 grams of safflower, Cortex Phellodendri 5-15 grams, 10-20 grams of Chinese violet, 5-15 grams of kelp.
Preferably
20 grams of ground bettle, 15 grams of tortoise plastron, 8 grams of long-noded pit viper, 15 grams of honeysuckle, 10 grams of prepared rehmannia root, 12 grams of dragon's blood, 15 grams of teasel root, crow 12 grams of tip snake, 12 grams of the root of bidentate achyranthes, 15 grams of oyster, 6 grams of scorpio, 15 grams of the rhizome of davallia, 12 grams of Semen Cuscutae, 12 grams of rhizoma cibotii, 15 grams of deer horn glue, 10 grams of cicada slough, 12 grams of Radix Notoginseng, 10 grams of frankincense, 10 grams of myrrh, 12 grams of the fruit of glossy privet, 15 grams of bletilla, 12 grams of moutan bark, coix seed 10 Gram, 6 grams of Prunella vulgaris, 8 grams of seaweed, 15 grams of corydalis tuber, 15 grams of carbonized hair, 10 grams of radix bupleuri, 12 grams of Radix Paeoniae Alba, 10 grams of safflower, Cortex Phellodendri 10 Gram, 15 grams of Chinese violet, 10 grams of kelp.
The preparation method of drug of the present invention is as follows
One, it stocks up
1, ground bettle：Take crude drug, cleaning, drying；
2, tortoise plastron：It is impregnated with clear water, scrapes off residual meat, cleaned, dry, knock fritter；
3, long-noded pit viper：It strikes off end to end, warm water softens, and dice dries；
4, honeysuckle：Silt is weeded out, net impurity is picked；
5, prepared rehmannia root：Select clean prepared rehmannia root；
6, dragon's blood：Wipe dust away, knock fritter, in winter dryness weather, being placed in lime altar makes dry, then multiplies crisp grind；
7, teasel root：Silt is cleaned, retained root head is removed, slice dries after moisturizing, and weeds out bits；
8, zaocys dhumnade：Crude drug is taken, grey bits, used time decaptitating, squama, segment are brushed away；
9, the root of bidentate achyranthes：Impurity is picked, is cleaned, is softened, reed, segment is gone to dry；
10, oyster：It cleans, dries, pulverize use；
11, scorpio：Clear water floats the matter that desalts, and dries or low baking temperature roasting is used；
12, the rhizome of davallia：Sediment contamination is removed, is cleaned, is slightly impregnated, moisturize, is sliced, dries；
13, Semen Cuscutae：It crosses square-bottomed bamboo basket and removes impurity, clean, dry；
14, rhizoma cibotii：It takes sand to set to fry in pot to light, addition picks net rhizoma cibotii, is fried with high heat to heaving and showing buff, is taken Go out, screen out sand, after wind dries in the air, hits or shave yellow villus；
15, deer horn glue：Crude drug is taken, removes impurity, the used time smashs to pieces or levigation；
16, cicada slough：Impurity is picked, cleans and dries；
17, Radix Notoginseng：Net impurity is picked, is smashed to pieces, slice dries after grinding or moisturizing；
18, frankincense：Pick sand impurity；
19, myrrh：Impurity is picked, fragment is broken into；
20, the fruit of glossy privet：Impurity is picked, cleans, dries；
21, bletilla：Impurity is picked, is soaked in water, is pulled out, dries in the air to uniform humidity inside and outside, is sliced, it is dry；
22, moutan bark：Impurity is picked, core is removed, cleans, moisturizes, is sliced, dries；
23, coix seed：Crude drug is taken, residual leather shell, impurity are removed；
24, Prunella vulgaris：Crude drug is taken, discarding stalk, blade and impurity is removed, weeds out grey bits；
25, seaweed：Impurity is picked, is slightly floated with water, is slightly dried in the air, segment is dried；
26, corydalis tuber：Impurity is picked, is soaked in water, is cleaned, solarization is dried in the air, and is moistened to uniform humidity inside and outside, is sliced or broken；
27, carbonized hair：Hair is taken, impurity is removed, buck washes away grease, and clear water rinses, and dries, bright to forge into charcoal, cools；
28, radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, pulls out, is sliced after moisturizing, dries immediately in time；
29, Radix Paeoniae Alba：Impurity is picked, size is separated, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, Slice, it is dry；
30, safflower：Net impurity is picked, cauline leaf, base of a fruit head is removed, dries；
31, Cortex Phellodendri：Impurity is picked, is eluted with water, is pulled out, is moisturized, slice or chopping are dried；
32, Chinese violet：Crude drug is taken, impurity is removed, cleans, slightly dries in the air, segment is dry；
33, kelp：Impurity is picked, is rinsed with water, wide silk is cut into, dries.
Two, it prepares
1, by the ground bettle of the weight, tortoise plastron, long-noded pit viper, honeysuckle, prepared rehmannia root, dragon's blood, teasel root, zaocys dhumnade, the root of bidentate achyranthes, male Oyster, scorpio, the rhizome of davallia, Semen Cuscutae, rhizoma cibotii, deer horn glue, cicada slough, Radix Notoginseng, frankincense, myrrh, the fruit of glossy privet, bletilla, moutan bark, Job's tears Benevolence, Prunella vulgaris, seaweed, corydalis tuber, carbonized hair, radix bupleuri, Radix Paeoniae Alba, safflower, Cortex Phellodendri, Chinese violet, kelp are put into decocting container, Add 8 times of amounts of water, after impregnating 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, it will First time decoction liquor is poured into container；
2, the dregs of a decoction of filtering are added into 6 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
3, it decoction liquor will be mixed evenly twice, and be divided into 4 doses and take.
Ground bettle broken stasis of blood blood in prescription, continuous muscles and bones, it is monarch drug in a prescription that tortoise plastron, which has nourishing and suppressing Yang, kidney tonifying, both functions of strong bone,；In vain Flower snake wind-damp dispelling, saturating muscles and bones, arresting convulsion are jerked, and honeysuckle has heat-clearing, the function of removing toxic substances, with prepared rehmannia root, dragon's blood, teasel root, zaocys dhumnade, ox Knee, oyster, scorpio, the rhizome of davallia are ministerial drug, and 12 taste medicines play broken stasis of blood blood, nourishing and suppressing Yang, clearing heat and detoxicating, continuous muscles and bones, dispel jointly Rheumatism, the effect jerked of arresting convulsion, treatment tuberculous osteoarthropathy effect is comprehensive, and with broken stasis of blood blood, nourishing and suppressing Yang, it is clearing heat and detoxicating based on, can It effects a permanent cure；Semen Cuscutae has filling liver kidney, benefiting quintessence, function and metastoma dodecandum lour, mengtzu peperomia, affine cudweed, Azolla imbricata, smallfruit fig leaf, the spider of improving eyesight Spider is fragrant, Uncinata Spikemoss Herb is adjutant；Bletilla has tonifying lung, stops blooding, and detumescence is raw to see, and the function of sore is to make medicine with remaining all medicines, is to control Mark.
Drug of the present invention has the function of broken stasis of blood blood, nourishing and suppressing Yang, clearing heat and detoxicating, filling liver kidney, benefiting quintessence, tonifying lung, is used for Treat tuberculous osteoarthropathy, short treating period, quick, non-relapse after healing.
Carry out the advantageous effect of the present invention is further explained the drug below by way of test example, these test examples include this hair The animal toxicity test report of bright drug and clinical observation on the therapeutic effect data.
The animal toxicity test of [test example 1] drug of the present invention is reported：
Rabbit 30, male and female dual-purpose, 2.0-2.5kg of weight is taken to be divided to two groups, every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode gives for administration by gavage Medicine even served 7 days twice daily, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and drug is without bad Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] drug of the present invention
1, general information
Accept tuberculous osteoarthropathy out-patient totally 39 for medical treatment.
2, diagnostic criteria
Classical symptom is：Joint function disturbance, swelling, pain, deformity etc..
3, therapy
Above-mentioned medicament is selected, is taken to patient, each taking 1 dose, early daily, evening respectively takes 1 time, 30 days as a treatment course, continuously It takes 3 course for the treatment of.
4, efficacy assessment standard
It is effective：Tuberculous osteoarthropathy symptom disappears, and restores normal, and follow-up 1 year is without recurrence；
It improves：Patient articular's dysfunction, swelling, pain, the phenomenon of deformity mitigate, and the symptoms were significantly improved for tuberculous osteoarthropathy, by Step restores normal；
In vain：Improvement standard person is not achieved.
5, treatment results（It see the table below）
In above-mentioned treatment, with drug therapy tuberculous osteoarthropathy patient 39 of the present invention, as a result effective 29, obvious effective rate is 74.36%, it improves 7, improvement rate 17.94%, invalid 3, total effective rate 92.3%.

Claims (3)

1. a kind of drug for treating tuberculous osteoarthropathy, it is characterised in that：It is made of the bulk pharmaceutical chemicals in following weight range：
15-20 grams of ground bettle, 10-20 grams of tortoise plastron, 5-10 grams of long-noded pit viper, 10-20 grams of honeysuckle, 5-15 grams of prepared rehmannia root, dragon's blood 10- 15 grams, 10-20 grams of teasel root, 10-15 grams of zaocys dhumnade, 10-15 grams of the root of bidentate achyranthes, 10-20 grams of oyster, 3-9 grams of scorpio, rhizome of davallia 10-20 Gram, 10-15 grams of Semen Cuscutae, 10-15 grams of rhizoma cibotii, 10-20 grams of deer horn glue, 5-15 grams of cicada slough, 10-15 grams of Radix Notoginseng, 5-15 grams of frankincense, 5-15 grams of myrrh, 10-15 grams of the fruit of glossy privet, 10-20 grams of bletilla, 10-15 grams of moutan bark, 5-15 grams of coix seed, 3-9 grams of Prunella vulgaris, 5-10 grams of seaweed, 10-20 grams of corydalis tuber, 10-20 grams of carbonized hair, 5-15 grams of radix bupleuri, 10-15 grams of Radix Paeoniae Alba, 5-15 grams of safflower, Cortex Phellodendri 5-15 grams, 10-20 grams of Chinese violet, 5-15 grams of kelp.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：
20 grams of ground bettle, 15 grams of tortoise plastron, 8 grams of long-noded pit viper, 15 grams of honeysuckle, 10 grams of prepared rehmannia root, 12 grams of dragon's blood, 15 grams of teasel root, crow 12 grams of tip snake, 12 grams of the root of bidentate achyranthes, 15 grams of oyster, 6 grams of scorpio, 15 grams of the rhizome of davallia, 12 grams of Semen Cuscutae, 12 grams of rhizoma cibotii, 15 grams of deer horn glue, 10 grams of cicada slough, 12 grams of Radix Notoginseng, 10 grams of frankincense, 10 grams of myrrh, 12 grams of the fruit of glossy privet, 15 grams of bletilla, 12 grams of moutan bark, coix seed 10 Gram, 6 grams of Prunella vulgaris, 8 grams of seaweed, 15 grams of corydalis tuber, 15 grams of carbonized hair, 10 grams of radix bupleuri, 12 grams of Radix Paeoniae Alba, 10 grams of safflower, Cortex Phellodendri 10 Gram, 15 grams of Chinese violet, 10 grams of kelp.
3. the preparation method of drug according to claim 1 or claim 2, it includes the following steps：
（One）Stock
（1）Ground bettle：Take crude drug, cleaning, drying；
（2）Tortoise plastron：It is impregnated with clear water, scrapes off residual meat, cleaned, dry, knock fritter；
（3）Long-noded pit viper：It strikes off end to end, warm water softens, and dice dries；
（4）Honeysuckle：Silt is weeded out, net impurity is picked；
（5）Prepared rehmannia root：Select clean prepared rehmannia root；
（6）Dragon's blood：Wipe dust away, knock fritter, in winter dryness weather, being placed in lime altar makes dry, then multiplies crisp grind；
（7）Teasel root：Silt is cleaned, retained root head is removed, slice dries after moisturizing, and weeds out bits；
（8）Zaocys dhumnade：Crude drug is taken, grey bits, used time decaptitating, squama, segment are brushed away；
（9）The root of bidentate achyranthes：Impurity is picked, is cleaned, is softened, reed, segment is gone to dry；
（10）Oyster：It cleans, dries, pulverize use；
（11）Scorpio：Clear water floats the matter that desalts, and dries or low baking temperature roasting is used；
（12）The rhizome of davallia：Sediment contamination is removed, is cleaned, is slightly impregnated, moisturize, is sliced, dries；
（13）Semen Cuscutae：It crosses square-bottomed bamboo basket and removes impurity, clean, dry；
（14）Rhizoma cibotii：It takes sand to set to fry in pot to light, addition picks net rhizoma cibotii, is fried with high heat to heaving and showing buff, is taken Go out, screen out sand, after wind dries in the air, hits or shave yellow villus；
（15）Deer horn glue：Crude drug is taken, removes impurity, the used time smashs to pieces or levigation；
（16）Cicada slough：Impurity is picked, cleans and dries；
（17）Radix Notoginseng：Net impurity is picked, is smashed to pieces, slice dries after grinding or moisturizing；
（18）Frankincense：Pick sand impurity；
（19）Myrrh：Impurity is picked, fragment is broken into；
（20）The fruit of glossy privet：Impurity is picked, cleans, dries；
（21）Bletilla：Impurity is picked, is soaked in water, is pulled out, dries in the air to uniform humidity inside and outside, is sliced, it is dry；
（22）Moutan bark：Impurity is picked, core is removed, cleans, moisturizes, is sliced, dries；
（23）Coix seed：Crude drug is taken, residual leather shell, impurity are removed；
（24）Prunella vulgaris：Crude drug is taken, discarding stalk, blade and impurity is removed, weeds out grey bits；
（25）Seaweed：Impurity is picked, is slightly floated with water, is slightly dried in the air, segment is dried；
（26）Corydalis tuber：Impurity is picked, is soaked in water, is cleaned, solarization is dried in the air, and is moistened to uniform humidity inside and outside, is sliced or broken；
（27）Carbonized hair：Hair is taken, impurity is removed, buck washes away grease, and clear water rinses, and dries, bright to forge into charcoal, cools；
（28）Radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, pulls out, is sliced after moisturizing, dries immediately in time；
（29）Radix Paeoniae Alba：Impurity is picked, size is separated, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, Slice, it is dry；
（30）Safflower：Net impurity is picked, cauline leaf, base of a fruit head is removed, dries；
（31）Cortex Phellodendri：Impurity is picked, is eluted with water, is pulled out, is moisturized, slice or chopping are dried；
（32）Chinese violet：Crude drug is taken, impurity is removed, cleans, slightly dries in the air, segment is dry；
（33）Kelp：Impurity is picked, is rinsed with water, wide silk is cut into, dries；
（Two）It prepares
（1）By the ground bettle of the weight, tortoise plastron, long-noded pit viper, honeysuckle, prepared rehmannia root, dragon's blood, teasel root, zaocys dhumnade, the root of bidentate achyranthes, male Oyster, scorpio, the rhizome of davallia, Semen Cuscutae, rhizoma cibotii, deer horn glue, cicada slough, Radix Notoginseng, frankincense, myrrh, the fruit of glossy privet, bletilla, moutan bark, Job's tears Benevolence, Prunella vulgaris, seaweed, corydalis tuber, carbonized hair, radix bupleuri, Radix Paeoniae Alba, safflower, Cortex Phellodendri, Chinese violet, kelp are put into decocting container, Add 8 times of amounts of water, after impregnating 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, it will First time decoction liquor is poured into container；
（2）The dregs of a decoction of filtering are added into 6 times of amounts of water, are boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
（3）It decoction liquor will be mixed evenly twice, and be divided into 4 doses and take.
CN201810927656.6A 2018-08-15 2018-08-15 A kind of drug and preparation method thereof for treating tuberculous osteoarthropathy Withdrawn CN108785567A (en)

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Application publication date: 20181113