CN108785425A - It is a kind of with the health care oral liquid to relax bowel - Google Patents

It is a kind of with the health care oral liquid to relax bowel Download PDF

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Publication number
CN108785425A
CN108785425A CN201811049216.1A CN201811049216A CN108785425A CN 108785425 A CN108785425 A CN 108785425A CN 201811049216 A CN201811049216 A CN 201811049216A CN 108785425 A CN108785425 A CN 108785425A
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parts
health care
oral liquid
liquid
extracting solution
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崔烓堃
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Shandong Heng Fu Wine Industry Co Ltd
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Shandong Heng Fu Wine Industry Co Ltd
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Priority to CN201811049216.1A priority Critical patent/CN108785425A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733Fructosans, e.g. inulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
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    • A61K36/68Plantaginaceae (Plantain Family)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of with the health care oral liquid to relax bowel, including below according to the raw material of parts by weight:100-150 parts of cassia seed extracting solution, 20-50 parts of radix scutellariae, 80-150 parts of jujube, 5-15 parts of plantain seed, 60-120 parts of fig, 40-80 parts of inulin, 5-12 parts of Radix Angelicae Sinensis, 15-20 parts of dried orange peel, 20-30 parts of indigo naturalis, 15-30 parts of Cortex Magnoliae Officinalis.The present invention cassia seed extracting solution, radix scutellariae, Radix Angelicae Sinensis in oral liquid material, dried orange peel magnolia obovata, to make the formula have relax bowel, beautifying face and moistering lotion and a variety of medical health care functions such as anti-oxidant, antifatigue, have a vast market foreground.

Description

It is a kind of with the health care oral liquid to relax bowel
Technical field
It is specifically a kind of with the health care oral liquid to relax bowel the present invention relates to oral solution technical field.
Background technology
Oral solution absorbs the process characteristic of traditional Chinese medicine, be by decoction further refine, concentration, embedding, sterilizing and It obtains.Oral solution be earliest by health products it is a kind of in the form of come across market, as Oral Liquid Radix Panacis Quinquefolii, member can oral solution, Ferulic acid etc.;And it is nearest, many therapeutic oral solutions have emerged in multitude in the formulation, such as chaihu oral liquid, Yupingfeng Oral solution, oral liquid of honeysuckle flower and scutellaria, antiviral oral liquor, heat-clearing and detoxicating oral liquid etc..Oral solution have taking dose it is small, absorb compared with Soon, stable quality, it is easy to carry and use, easy to maintain the advantages that, be especially suitable for industrialized production.Some kinds may be adapted to Chinese medicine Acute disease medication such as Sini Tang oral solution, oral liquid of honeysuckle flower and scutellaria, therefore in recent years mostly closes tablet, granule, pill, decoction, Chinese medicine Agent, injection etc. are converted into oral solution, make and develop one of faster dosage form in pharmaceutical preparation.But the production of oral solution is set The requirement of standby and process conditions is all higher, and cost is costly.
The various defaecation ease constipation product sold on the market now, the good and bad jumbled together for drug, most of only simple cathartics, allows people A large amount of dehydrations cause the huge injury of human body, and are respectively provided with ease constipation beauty treatment or anti-in domestic oral solution product market at present Tired, strengthen immunity function oral solution gradually increases, but without the effect of relaxing bowel.
Invention content
The purpose of the present invention is to provide a kind of with the health care oral liquid to relax bowel, to solve in above-mentioned background technology The problem of proposition.
To achieve the above object, the present invention provides the following technical solutions:
It is a kind of with the health care oral liquid to relax bowel, including below according to the raw material of parts by weight:Cassia seed extracting solution 100-150 Part, 20-50 parts of radix scutellariae, 80-150 parts of jujube, 5-15 parts of plantain seed, 60-120 parts of fig, 40-80 parts of inulin, Radix Angelicae Sinensis 5-12 Part, 15-20 parts of dried orange peel, 20-30 parts of indigo naturalis, 15-30 parts of Cortex Magnoliae Officinalis.
As a further solution of the present invention:Including below according to the raw material of parts by weight:Cassia seed extracting solution 100-120 Part, 20-40 parts of radix scutellariae, 80-120 parts of jujube, 5-10 parts of plantain seed, 60-80 parts of fig, 40-60 parts of inulin, 5-7 parts of Radix Angelicae Sinensis, 15-18 parts of dried orange peel, 20-25 parts of indigo naturalis, 15-20 parts of Cortex Magnoliae Officinalis.
As further scheme of the invention:Including below according to the raw material of parts by weight:110 parts of cassia seed extracting solution, 30 parts of radix scutellariae, 100 parts of jujube, 8 parts of plantain seed, 70 parts of fig, 50 parts of inulin, 6 parts of Radix Angelicae Sinensis, 16 parts of dried orange peel, 25 parts of indigo naturalis, thickness 20 parts of Piao.
The preparation method with the health care oral liquid to relax bowel, which is characterized in that steps are as follows:
1)Each raw material is weighed by weight;
2)The cassia seed of harvest is taken to clean, the drying time at 7-12 hours, parches;It is then placed in big iron pan and stir-fries, first After downward upwards, firmly uniform, when Cassia sub-color starts to black, beginning small fire stir-fries 10-15 minutes and is molded;When color at For dark brown when, naturally dry after taking-up, be put into 10 times amount ethyl alcohol in, impregnate 1-2 hour, supernatant is removed after heating extraction, conjunction And extracting solution, the filtration of 100-120 mesh, then through the ultrafiltration column ultrafiltration that molecular weight is 5000-10000 of shutting off, ultrafiltrate is concentrated under reduced pressure 1.05 filtrate, as cassia seed extracting solution when relative density is 80 DEG C;
3)Remaining raw material is first processed with tradition and breaking method processes, then is crushed using research of super-pine crush equipment processing, institute is made The drug granule grain size of crushing is spare between reaching 1-150 microns;Said medicine particle is packed in fine cloth bag, is put into Decocting pot It is interior, add 3-6 times of water to decoct 1-2 hours, filter juice preserves, remaining dregs of a decoction adds 2-4 times of water to decoct 0.5-1 hours again, filtered juice After remove the dregs of a decoction, will successively two juice be filtered after merging, and when filtrate is concentrated into 1 milliliter of liquid and is equivalent to 2 grams of crude drug, let cool, medicine is added 95% ethyl alcohol of 2 times of liquid amount, stir evenly placement 1-2 days, after ethyl alcohol to be recycled, then use appropriate distilled water, filter, then by by every 100- In the medicinal extract that 300 grams of Chinese medicine materials decoct, appropriate distilled water is added to 1000 milliliters, refrigerates, filtration is packaged in 5-10 milliliters It is sealed in bottle, liquid A is obtained after sterilizing;
4)Cassia seed extracting solution and liquid A are mixed and are placed on, refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate It is placed in again in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml crude drug amounts containing 0.1g, then add dextrin, bottle after ultraviolet sterilization, i.e., Obtain the health care oral liquid for having and relaxing bowel.
As a further solution of the present invention:Step 2)In, the number of the heating extraction be twice, it is 1-2 hours each.
As further scheme of the invention:Step 3)In, sterilizing methods are that 100 DEG C of boiling water sterilize 60 minutes.
As further scheme of the invention:Step 4)In, refrigerated storage temperature is 0-3 DEG C, and cold preservation time is 48 hours.
Compared with prior art, the beneficial effects of the invention are as follows:The present invention cassia seed extracting solution, Huang in oral liquid material A kind of reed mentioned in ancient books, Radix Angelicae Sinensis, dried orange peel magnolia obovata, to make the formula have relax bowel, beautifying face and moistering lotion and a variety of medical treatment such as anti-oxidant, antifatigue Healthcare function has a vast market foreground.
Specific implementation mode
Technical scheme of the present invention is described in more detail With reference to embodiment.
Embodiment 1
It is a kind of with the health care oral liquid to relax bowel, including below according to the raw material of parts by weight:100 parts of cassia seed extracting solution, 20 parts of radix scutellariae, 80 parts of jujube, 5 parts of plantain seed, 60 parts of fig, 40 parts of inulin, 5 parts of Radix Angelicae Sinensis, 15 parts of dried orange peel, 20 parts of indigo naturalis, thickness 15 parts of Piao.
The preparation method with the health care oral liquid to relax bowel, which is characterized in that steps are as follows:
1)Each raw material is weighed by weight;
2)The cassia seed of harvest is taken to clean, the drying time at 7 hours, parches;It is then placed in big iron pan and stir-fries, first downwards Afterwards upwards, firmly uniform, when Cassia sub-color starts to black, beginning small fire stir-fries 10 minutes and is molded;When color becomes dark brown When color, naturally dry after taking-up is put into 10 times of amount ethyl alcohol, impregnates 1 hour, supernatant is removed after heating extraction, merge extracting solution, 100 mesh filter, then the ultrafiltration column ultrafiltration for being 5000 through the molecular weight that shuts off, and ultrafiltrate is concentrated under reduced pressure 1.05 when relative density is 80 DEG C Filtrate, as cassia seed extracting solution;
3)Remaining raw material is first processed with tradition and breaking method processes, then is crushed using research of super-pine crush equipment processing, institute is made The drug granule grain size of crushing is spare between reaching 1 micron;Said medicine particle is packed in fine cloth bag, is put into Decocting pot, adds 3 Water again decocts 1 hour, and filter juice preserves, remaining dregs of a decoction adds 2 times of water to decoct 0.5 hour again, and the dregs of a decoction are removed after filtered juice, will priority Two juice filter after merging, and when filtrate is concentrated into 1 milliliter of liquid and is equivalent to 2 grams of crude drug, let cool, 95% second of 2 times of amounts of liquid are added Alcohol stirs evenly placement 1 day, after ethyl alcohol to be recycled, then uses appropriate distilled water, filtration, then by being decocted by every 100 grams of Chinese medicine materials In medicinal extract, appropriate distilled water is added to 1000 milliliters, refrigerates, filtration is packaged in 5 milliliters of bottles and seals, and liquid A is obtained after sterilizing;
4)Cassia seed extracting solution and liquid A are mixed and are placed on, refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate It is placed in again in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml crude drug amounts containing 0.1g, then add dextrin, bottle after ultraviolet sterilization, i.e., Obtain the health care oral liquid for having and relaxing bowel.
Step 2)In, the number of the heating extraction is 1 hour every time twice.
Step 3)In, sterilizing methods are that 100 DEG C of boiling water sterilize 60 minutes.
Step 4)In, refrigerated storage temperature is 0 DEG C, and cold preservation time is 48 hours.
Embodiment 2
It is a kind of with the health care oral liquid to relax bowel, including below according to the raw material of parts by weight:150 parts of cassia seed extracting solution, 50 parts of radix scutellariae, 150 parts of jujube, 15 parts of plantain seed, 120 parts of fig, 80 parts of inulin, 12 parts of Radix Angelicae Sinensis, 20 parts of dried orange peel, indigo naturalis 30 Part, 30 parts of Cortex Magnoliae Officinalis.
The preparation method with the health care oral liquid to relax bowel, which is characterized in that steps are as follows:
1)Each raw material is weighed by weight;
2)The cassia seed of harvest is taken to clean, the drying time at 12 hours, parches;Be then placed in big iron pan and stir-fry, first to After down upwards, firmly uniform, when Cassia sub-color starts to black, beginning small fire stir-fries 15 minutes and is molded;When color becomes black When brown, naturally dry after taking-up is put into 10 times of amount ethyl alcohol, impregnates 2 hours, supernatant is removed after heating extraction, merge extraction Liquid, 120 mesh filter, then the ultrafiltration column ultrafiltration for being 10000 through the molecular weight that shuts off, when ultrafiltrate reduced pressure relative density is 80 DEG C 1.05 filtrate, as cassia seed extracting solution;
3)Remaining raw material is first processed with tradition and breaking method processes, then is crushed using research of super-pine crush equipment processing, institute is made The drug granule grain size of crushing is spare between reaching 150 microns;Said medicine particle is packed in fine cloth bag, is put into Decocting pot, 6 times of water is added to decoct 2 hours, filter juice preserves, remaining dregs of a decoction adds 4 times of water to decoct 1 hour again, and the dregs of a decoction are removed after filtered juice, will be first Two juice filter after merging afterwards, when filtrate is concentrated into 1 milliliter of liquid and is equivalent to 2 grams of crude drug, let cool, the 95% of 2 times of amounts of liquid is added Ethyl alcohol stirs evenly placement 2 days, after ethyl alcohol to be recycled, then uses appropriate distilled water, filtration, then press by the decoction of every 300 grams of Chinese medicine materials at Medicinal extract in, appropriate distilled water is added to 1000 milliliters, refrigerates, filtration is packaged in 10 milliliters of bottles and seals, after sterilizing liquid A;
4)Cassia seed extracting solution and liquid A are mixed and are placed on, refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate It is placed in again in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml crude drug amounts containing 0.1g, then add dextrin, bottle after ultraviolet sterilization, i.e., Obtain the health care oral liquid for having and relaxing bowel.
Step 2)In, the number of the heating extraction is 2 hours every time twice.
Step 3)In, sterilizing methods are that 100 DEG C of boiling water sterilize 60 minutes.
Step 4)In, refrigerated storage temperature is 3 DEG C, and cold preservation time is 48 hours.
Embodiment 3
It is a kind of with the health care oral liquid to relax bowel, including below according to the raw material of parts by weight:120 parts of cassia seed extracting solution, 30 parts of radix scutellariae, 120 parts of jujube, 10 parts of plantain seed, 100 parts of fig, 60 parts of inulin, 8 parts of Radix Angelicae Sinensis, 18 parts of dried orange peel, 25 parts of indigo naturalis, 25 parts of Cortex Magnoliae Officinalis.
The preparation method with the health care oral liquid to relax bowel, which is characterized in that steps are as follows:
1)Each raw material is weighed by weight;
2)The cassia seed of harvest is taken to clean, the drying time at 10 hours, parches;Be then placed in big iron pan and stir-fry, first to After down upwards, firmly uniform, when Cassia sub-color starts to black, beginning small fire stir-fries 12 minutes and is molded;When color becomes black When brown, naturally dry after taking-up is put into 10 times of amount ethyl alcohol, impregnates 1.5 hours, supernatant, merging is gone to carry after heating extraction Liquid, the filtration of 110 mesh are taken, then the ultrafiltration column ultrafiltration for being 6000 through the molecular weight that shuts off, it is 80 DEG C that relative density, which is concentrated under reduced pressure, in ultrafiltrate When 1.05 filtrate, as cassia seed extracting solution;
3)Remaining raw material is first processed with tradition and breaking method processes, then is crushed using research of super-pine crush equipment processing, institute is made The drug granule grain size of crushing is spare between reaching 100 microns;Said medicine particle is packed in fine cloth bag, is put into Decocting pot, 4 times of water is added to decoct 1.5 hours, filter juice preserves, remaining dregs of a decoction adds 3 times of water to decoct 0.8 hour again, and the dregs of a decoction are removed after filtered juice, It will successively two juice be filtered after merging, and when filtrate is concentrated into 1 milliliter of liquid and is equivalent to 2 grams of crude drug, let cool, 2 times of amounts of liquid are added 95% ethyl alcohol stirs evenly placement 1 day, after ethyl alcohol to be recycled, then uses appropriate distilled water, filters, then decocted by by every 200 grams of Chinese medicine materials In the medicinal extract being cooked into, appropriate distilled water being added to 1000 milliliters, refrigerates, filtration is packaged in 6 milliliters of bottles and seals, after sterilizing Liquid A;
4)Cassia seed extracting solution and liquid A are mixed and are placed on, refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate It is placed in again in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml crude drug amounts containing 0.1g, then add dextrin, bottle after ultraviolet sterilization, i.e., Obtain the health care oral liquid for having and relaxing bowel.
Step 2)In, the number of the heating extraction is 1.5 hours every time twice.
Step 3)In, sterilizing methods are that 100 DEG C of boiling water sterilize 60 minutes.
Step 4)In, refrigerated storage temperature is 2 DEG C, and cold preservation time is 48 hours.
Embodiment 4
It is a kind of with the health care oral liquid to relax bowel, including below according to the raw material of parts by weight:110 parts of cassia seed extracting solution, 30 parts of radix scutellariae, 100 parts of jujube, 8 parts of plantain seed, 70 parts of fig, 50 parts of inulin, 6 parts of Radix Angelicae Sinensis, 16 parts of dried orange peel, 25 parts of indigo naturalis, thickness 20 parts of Piao.
The preparation method with the health care oral liquid to relax bowel, which is characterized in that steps are as follows:
1)Each raw material is weighed by weight;
2)The cassia seed of harvest is taken to clean, the drying time at 7-12 hours, parches;It is then placed in big iron pan and stir-fries, first After downward upwards, firmly uniform, when Cassia sub-color starts to black, beginning small fire stir-fries 10-15 minutes and is molded;When color at For dark brown when, naturally dry after taking-up, be put into 10 times amount ethyl alcohol in, impregnate 1-2 hour, supernatant is removed after heating extraction, conjunction And extracting solution, the filtration of 100-120 mesh, then through the ultrafiltration column ultrafiltration that molecular weight is 5000-10000 of shutting off, ultrafiltrate is concentrated under reduced pressure 1.05 filtrate, as cassia seed extracting solution when relative density is 80 DEG C;
3)Remaining raw material is first processed with tradition and breaking method processes, then is crushed using research of super-pine crush equipment processing, institute is made The drug granule grain size of crushing is spare between reaching 50 microns;Said medicine particle is packed in fine cloth bag, is put into Decocting pot, adds 5 times of water decocts 1.5 hours, and filter juice preserves, remaining dregs of a decoction adds 3 times of water to decoct 0.8 hour again, and the dregs of a decoction are removed after filtered juice, will Successively two juice filter after merging, and when filtrate is concentrated into 1 milliliter of liquid and is equivalent to 2 grams of crude drug, let cool, 2 times of amounts of liquid are added 95% ethyl alcohol stirs evenly placement 2 days, after ethyl alcohol to be recycled, then uses appropriate distilled water, filters, then decocted by by every 200 grams of Chinese medicine materials In the medicinal extract being cooked into, appropriate distilled water being added to 1000 milliliters, refrigerates, filtration is packaged in 8 milliliters of bottles and seals, after sterilizing Liquid A;
4)Cassia seed extracting solution and liquid A are mixed and are placed on, refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate It is placed in again in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml crude drug amounts containing 0.1g, then add dextrin, bottle after ultraviolet sterilization, i.e., Obtain the health care oral liquid for having and relaxing bowel.
As a further solution of the present invention:Step 2)In, the number of the heating extraction is 2 hours every time twice.
As further scheme of the invention:Step 3)In, sterilizing methods are that 100 DEG C of boiling water sterilize 60 minutes.
As further scheme of the invention:Step 4)In, refrigerated storage temperature is 0 DEG C, and cold preservation time is 48 hours.
The present invention cassia seed extracting solution, radix scutellariae, Radix Angelicae Sinensis, dried orange peel magnolia obovata, to make the formula have in oral liquid material It relaxes bowel, beautifying face and moistering lotion and a variety of medical health care functions such as anti-oxidant, antifatigue, has a vast market foreground.
The better embodiment of the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party Formula, one skilled in the relevant art within the scope of knowledge, can also be without departing from the purpose of the present invention Various changes can be made.

Claims (7)

1. a kind of with the health care oral liquid to relax bowel, which is characterized in that including below according to the raw material of parts by weight:Cassia seed 100-150 parts of extracting solution, 20-50 parts of radix scutellariae, 80-150 parts of jujube, 5-15 parts of plantain seed, 60-120 parts of fig, inulin 40- 80 parts, 5-12 parts of Radix Angelicae Sinensis, 15-20 parts of dried orange peel, 20-30 parts of indigo naturalis, 15-30 parts of Cortex Magnoliae Officinalis.
2. according to claim 1 with the health care oral liquid to relax bowel, which is characterized in that including below according to weight The raw material of part:100-120 parts of cassia seed extracting solution, 20-40 parts of radix scutellariae, 80-120 parts of jujube, 5-10 parts of plantain seed, fig 60-80 parts, 40-60 parts of inulin, 5-7 parts of Radix Angelicae Sinensis, 15-18 parts of dried orange peel, 20-25 parts of indigo naturalis, 15-20 parts of Cortex Magnoliae Officinalis.
3. according to claim 1 with the health care oral liquid to relax bowel, which is characterized in that including below according to weight The raw material of part:110 parts of cassia seed extracting solution, 30 parts of radix scutellariae, 100 parts of jujube, 8 parts of plantain seed, 70 parts of fig, 50 parts of inulin, 6 parts of Radix Angelicae Sinensis, 16 parts of dried orange peel, 25 parts of indigo naturalis, 20 parts of Cortex Magnoliae Officinalis.
4. a kind of preparation method as described in any one of claims 1-3 with the health care oral liquid to relax bowel, feature exist In steps are as follows:
1)Each raw material is weighed by weight;
2)The cassia seed of harvest is taken to clean, the drying time at 7-12 hours, parches;It is then placed in big iron pan and stir-fries, first After downward upwards, firmly uniform, when Cassia sub-color starts to black, beginning small fire stir-fries 10-15 minutes and is molded;When color at For dark brown when, naturally dry after taking-up, be put into 10 times amount ethyl alcohol in, impregnate 1-2 hour, supernatant is removed after heating extraction, conjunction And extracting solution, the filtration of 100-120 mesh, then through the ultrafiltration column ultrafiltration that molecular weight is 5000-10000 of shutting off, ultrafiltrate is concentrated under reduced pressure 1.05 filtrate, as cassia seed extracting solution when relative density is 80 DEG C;
3)Remaining raw material is first processed with tradition and breaking method processes, then is crushed using research of super-pine crush equipment processing, institute is made The drug granule grain size of crushing is spare between reaching 1-150 microns;Said medicine particle is packed in fine cloth bag, is put into Decocting pot It is interior, add 3-6 times of water to decoct 1-2 hours, filter juice preserves, remaining dregs of a decoction adds 2-4 times of water to decoct 0.5-1 hours again, filtered juice After remove the dregs of a decoction, will successively two juice be filtered after merging, and when filtrate is concentrated into 1 milliliter of liquid and is equivalent to 2 grams of crude drug, let cool, medicine is added 95% ethyl alcohol of 2 times of liquid amount, stir evenly placement 1-2 days, after ethyl alcohol to be recycled, then use appropriate distilled water, filter, then by by every 100- In the medicinal extract that 300 grams of Chinese medicine materials decoct, appropriate distilled water is added to 1000 milliliters, refrigerates, filtration is packaged in 5-10 milliliters It is sealed in bottle, liquid A is obtained after sterilizing;
4)Cassia seed extracting solution and liquid A are mixed and are placed on, refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate It is placed in again in economic benefits and social benefits vacuum concentrator, is concentrated into every 1ml crude drug amounts containing 0.1g, then add dextrin, bottle after ultraviolet sterilization, i.e., Obtain the health care oral liquid for having and relaxing bowel.
5. the preparation method according to claim 4 with the health care oral liquid to relax bowel, which is characterized in that step 2) In, the number of the heating extraction be twice, it is 1-2 hours each.
6. the preparation method according to claim 4 with the health care oral liquid to relax bowel, which is characterized in that step 3) In, sterilizing methods are that 100 DEG C of boiling water sterilize 60 minutes.
7. the preparation method according to claim 4 with the health care oral liquid to relax bowel, which is characterized in that step 4) In, refrigerated storage temperature is 0-3 DEG C, and cold preservation time is 48 hours.
CN201811049216.1A 2018-09-10 2018-09-10 It is a kind of with the health care oral liquid to relax bowel Withdrawn CN108785425A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114680333A (en) * 2022-04-06 2022-07-01 湖南盛世丰花生物科技股份有限公司 Oral liquid with bowel relaxing function

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114680333A (en) * 2022-04-06 2022-07-01 湖南盛世丰花生物科技股份有限公司 Oral liquid with bowel relaxing function
CN114680333B (en) * 2022-04-06 2024-03-12 湖南盛世丰花生物科技股份有限公司 Oral liquid with bowel relaxing function

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