CN108785366A - A kind of composition to relax bowel and its application - Google Patents
A kind of composition to relax bowel and its application Download PDFInfo
- Publication number
- CN108785366A CN108785366A CN201810930637.9A CN201810930637A CN108785366A CN 108785366 A CN108785366 A CN 108785366A CN 201810930637 A CN201810930637 A CN 201810930637A CN 108785366 A CN108785366 A CN 108785366A
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- China
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- raw material
- composition
- prepared
- folium sennae
- constipation
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The present invention relates to a kind of compositions to relax bowel, in parts by weight, are prepared using the raw material including following ingredient：0.01~6 part of folium sennae, 0.01~15 part of Siraitia grosvenorii, 0.1~10 part of campanulaceae.Composition provided by the invention can be used for preparing the food or health products to relax bowel, can be also used for preparing the drug for preventing or treating constipation.Raw material selected by the present invention is safe to the human body, environmentally friendly；The present invention creatively has found, these types of ingredient progress compatibility is used in combination, and can play effect that is synergistic, mitigating toxic side effect, can effective prophylactic treatment constipation, great help is provided to the patient perplexed for a long time by constipation.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of composition to relax bowel and its application.
Background technology
Constipation (constipation) is clinical common complicated symptom, rather than a kind of disease, shows as defecation frequency
It reduces, excrement is stiff and (or) difficult defecation.Defecation frequency reduction refers to weekly defecation and is less than 3 times.Difficult defecation includes defecation expense
Power, discharge is difficult, defecation is felt not to the utmost, defecation is time-consuming and needs gimmick defecation assisting.The chronic constipation course of disease is at least 6 months.
With the influence of the change of people's dietary structure and psychiatric and social factor, constipation incidence, which has to increase, to become
Gesture.Illness rate of the constipation in crowd is up to 27%, but only sub-fraction constipation person can go to a doctor.Constipation can influence each age
The people of section.Women is more than male, and old age is more than the green, prime of life.Because constipation incidence is high, the cause of disease is complicated, patient often has manifold vexations,
Constipation can influence quality of life when serious.
The Alarm sign of constipation include have blood in stool, anaemia, become thin, generate heat, melena, abdominal pain etc. and Family history of cancer.If
Hospital admission should be removed at once by alarm sign occur, make further to check.Since constipation is a kind of more universal symptom, mild symptoms
Differ again, most people usually do not go special to comprehend, it is believed that constipation is not disease, does not have to treatment, but the harm of actually constipation is very
Greatly.Constipation some diseases such as colon cancer, hepatic encephalopathy, mammary gland disease, alzheimer's disease generation in play an important role, this side
There are many research reports in face；Constipation can cause life unexpected in acute myocardial infarction AMI, cerebrovascular accident patient, there is many painful things
Example let us vigilance；Part constipation and anorectal disease, such as hemorrhoid, anal fissure have close relationship.
The drug of common treatment constipation has:1. displacement type purgatives, such purgatives can increase the volume of stool, to enhance excrement
Just to the stimulation of enteron aisle receptor, there are commonly dietary fiber, fructose, sorbierite, mannitol, polyethylene glycol and saline laxatives.
After, the osmotic pressure of enteric cavity part can be made to increase, moisture absorption is reduced, and faecal volume increases.Dietary fiber and fructose, though
It Small side effects but works slow, is not suitable as the rapid defaecation treatment of temporary constipation；And saline laxative such as phenolphthalein tablet, have very big
Side effect, informal dress will produce drug resistance, deactivates and aggravates constipation, easily cause intestinal disorder, generate dependence.2. lubricity is rushed down
Agent：It is not absorbed in enteron aisle, but can interfere with the absorption of moisture, therefore often play the role of lubricating intestinal wall, softer stool, commonly used
Have atoleine, glycerine and plant oil.The such purgatives of prolonged application influence the absorption of vitamin and calcium, also will produce anus
Irritation.3. irritant purgative：Rheum officinale and folium sennae tablet preparation.Such purgatives is influenced because having stimulation to intestinal mucosa
The absorption of moisture and electrolyte in enteron aisle, therefore there is stronger catharsis to act on.This kind of higher strong, some goes back toxic side effect, therefore
Old and frail, pregnant woman, postpartum, weakness due to chronic disease, Tianjin impairment of yin is lost, deficiency of blood person should all use with caution.Purgative drugs prescriptions easily injures one's stomach gas, proves effective and stops,
Clothes can not be crossed.
At present, it would be highly desirable to a kind of safety, no dependence, product with obvious effects, target user is extensive are developed, from early prevention
And improve constipation situation, it avoids constipation from having serious consequences, improves people's body sub-health state, improve the quality of living.
Invention content
The purpose of the present invention is overcoming the deficiencies of existing technologies, a kind of composition with function of relaxing bowel is provided.This
It invents the composition provided several ingredients progress compatibility is used in combination, effect that is synergistic, mitigating toxic side effect can be played
Fruit, to effective prophylactic treatment constipation.
Specifically, the present invention provides a kind of compositions to relax bowel, in parts by weight, using including following ingredient
Raw material be prepared：
0.01~6 part of folium sennae；
0.01~15 part of Siraitia grosvenorii；
0.1~10 part of campanulaceae.
Preferably, it is prepared using the raw material including following ingredient：
0.2~6 part of folium sennae；
0.2~10 part of Siraitia grosvenorii；
0.3~10 part of campanulaceae.
It is highly preferred that the raw material that use includes following ingredient is prepared：
0.2~2 part of folium sennae；
0.2~3 part of Siraitia grosvenorii；
0.3~3.6 part of campanulaceae.
It is further preferred that the raw material that use includes following ingredient is prepared：
0.7~1.5 part of folium sennae；
0.2~2 part of Siraitia grosvenorii；
0.4~1 part of campanulaceae.
As a preferred embodiment of the present invention, the composition to relax bowel be with the folium sennae of above-mentioned dosage part,
Siraitia grosvenorii and campanulaceae are prepared as a raw material.
The folium sennae that the present invention uses is the general designation of legume Cassia Angustifolia leaf or the drying leaflet of cassia acutifolia Delile leaf.Kind
Ye Gan is rushed down, hardship, trembles with fear, return large intestine channel, is a kind of common purgatives medicine, the stagnant row that has the function of to purge heat, defaecation, sharp water.Heat knot product
Stagnant, constipation abdominal pain, oedema turgor, clinic have been widely used as catharsis agent.The main component of folium sennae is sennoside A, B.It is modern
Pharmacology proves：Folium sennae also has the effects that antibacterial, hemostasis and spasmolysis of flaccid muscles in addition to discharge function.Clinically use cassia angustifolia
Leaf treats various bleedings and solid, and clinical effectiveness shows that this tool has a better effect.
The Siraitia grosvenorii that the present invention uses is cool in nature, sweet in flavor, nontoxic for the dry fruit of Curcurbitaceae Siraitia grosvenorii, return lung, large intestine
Through, moisten the lung and relieve the cough, cool blood laxation the effect of, for treating lung-fire cough caused by dryness, pharyngalgia aphonia, dry constipation of intestines etc..
The campanulaceae that the present invention uses is the root of the drying of campanulaceae.Spring, the excavation of two season of autumn, clean, remove fibrous root, take advantage of fresh peel off
Crust does not remove crust, dry.It is bitter, pungent, flat, distributed in lung channel.Cure mainly facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, chest
It is bored unsmooth, pharyngalgia hoarse voice, lung carbuncle pyemesis.
Raw material selected by the present invention is safe to the human body, environmentally friendly.In above-mentioned preferred embodiment, folium sennae enters large intestine
Through, the row that expels the heat-evil is stagnant, and defaecation is monarch drug in a prescription, and ministerial drug is aided with the Siraitia grosvenorii of clearing lung-heat ease constipation, coordinates facilitaing lung apocenosis, the campanulaceae of chest distress,
Siraitia grosvenorii is mutually combined into adjutant with campanulaceae, to play the effect of " carry pot and take off lid ".These types of ingredient progress compatibility is used in combination, it can
To play synergistic effect, it can especially mitigate the toxic side effect of each component, it can effective prophylactic treatment constipation.
The present invention is further preferably added on the basis of selecting folium sennae, Siraitia grosvenorii and this special formulation of campanulaceae
One or both of lily, rde bean are as medicine is made, and to coordinating the drug actions of a prescription, especially mitigate the high violent pharmacological property of folium sennae；When
When being shared simultaneously with above-mentioned raw materials with rde bean using lily, the effect of ease constipation, defaecation, Er Qieneng can be not only further increased
Enough substantially reduced toxic side effects brought by folium sennae.It complements each other, acts synergistically, to reach ultimate attainment between above-mentioned each raw material
Effect.
The lily that the present invention uses is the dry meat scale leaf of liliaceous plant.Its is sweet in flavor and cold in property, distributed in heart and lung channels.Have
The effect of Yin nourishing and lung moistening cough-relieving, clearing away the heart fire and tranquillizing, be clinically used for treatment cough caused by dryness-heat, overstrain cough chronic cough, blood-stained sputum, dysphoria palpitates with fear,
It is insomnia and dreamful sleep, absent-minded.《This warp》,《Compendium of Materia Medica》In described lily " sharp stool and urine, tonifying middle-Jiao and Qi ", explicitly point out
It has the function of tonneau stool.For folium sennae, Siraitia grosvenorii and the campanulaceae synergistic effect with above-mentioned special ratios, the present invention
It is preferred that in preparing the raw material of the composition, the dosage of lily is 0.2~12 part, more preferably 1~7 part, further preferably 2
~5 parts.
The rde bean that the present invention uses is legume rde bean or the dry mature seed of red bean.Red bean is as a kind of
Coarse cereals, medical value are higher.Chinese medicine thinks that red bean is mild-natured, sweet in flavor, sour, have invigorating spleen for diuresis, eliminating dampness and heat and blood apocenosis,
Removing toxicity for detumescence and other effects.All spleen deficiency is uncomfortable, and ascites turgor, jaundice, rush down dysentery, is had blood in stool and purulent disease at difficult urination, all may be used
Consider food.In addition, red bean contains more dietary fiber, relax bowel with good, blood pressure lowering, reducing blood lipid is adjusted
Blood glucose, detoxicating and fighting cancer prevent calculus, the effect of body building and weight reducing.For folium sennae, Siraitia grosvenorii and the tangerine with above-mentioned special ratios
Stalk synergistic effect, the present invention preferably prepared in the raw material of the composition, and the dosage of rde bean is 0.2~30 part, and more preferably 2
~12 parts, further preferably 8~9 parts.
As present invention further optimization scheme, it includes that the raw material of following ingredient is prepared that the composition, which uses,：
As present invention further optimization scheme, it includes that the raw material of following ingredient is prepared that the composition, which uses,：
As present invention further optimization scheme, it includes that the raw material of following ingredient is prepared that the composition, which uses,：
As present invention further optimization scheme, it includes that the raw material of following ingredient is prepared that the composition, which uses,：
As the further preferred embodiment of the present invention, the composition to relax bowel is with the cassia angustifolia of above-mentioned dosage part
The raw material that leaf, Siraitia grosvenorii, campanulaceae, lily and rde bean form is prepared.
Composition provided by the invention can be mixed according to the method for this field routine, can also first be mixed to raw material
It is extracted with solvent after conjunction and obtains extract, first raw material can also be extracted with identical or different solvent respectively
Afterwards, extract is mixed.
In order to further increase the effect that relaxes bowel of above-mentioned composition, and convenient for mixing system with auxiliary material as active ingredient
Standby product, the preferably described composition of the present invention are prepared with the following method：
(1) folium sennae is taken, is extracted with ethyl alcohol, alcohol extract is obtained；
(2) remaining raw material is taken, is extracted with water after mixing, obtains water extract；
(3) alcohol extract is mixed with water extract to get；
Preferably, step (3) is first respectively dried the alcohol extract and water extract, then is mixed.
The present invention is extracted by largely putting into practice discovery, by folium sennae with ethyl alcohol, and by remaining starting material with water extract after, gained
Extract the active ingredient to relax bowel can be enriched with to greatest extent, and using above-mentioned specific preparation method it is obtained
Composition can not only play synergistic effect, but also can be chosen to remove toxic pair by extraction scheme between active ingredient
The ingredient of effect, to provide a kind of effective and safe composition.
The ethyl alcohol that the preferred above-mentioned steps of the present invention (1) use for 70~75% ethanol water.The present invention passes through a large amount of
Practice finds, folium sennae is extracted using 70~75% ethanol water can play it is best with other water extracts it
Between synergistic function.The present invention is further preferably adjusted to 1.5~2.5, to ensure the pH value of the alcohol extract
Target components are enriched with to the greatest extent.As a kind of specific preferred embodiment of the present invention, the step (1) is：Take folium sennae, powder
It is impregnated with 70~75% ethanol water after broken, ultrasonic extraction, centrifuging and taking supernatant, concentration, after adjusting pH is 1.5~2.5,
Centrifuging and taking precipitates, and obtains alcohol extract.
The present invention protects application of the composition in preparing the food or health products that relax bowel simultaneously.
Specifically, the food or health products provided by the invention to relax bowel, be using the composition as active ingredient,
The customary adjuvant of food or health products is added, is prepared according to the conventional method of this field.
The present invention protects the composition preparing the application in preventing or treating the drug of constipation simultaneously.
As a kind of concrete application mode, for preventing or treating the drug of constipation using the composition as active ingredient,
The customary adjuvant of drug is added, is prepared according to the conventional method of this field.The drug is preferably peroral dosage form, such as common
Tablet, capsule, oral solution etc..It is taken for the ease of patient, and ease constipation is played in a manner of best pharmacokinetics
The effect of defaecation, the preferably described drug of the present invention are tablet.
It is also wrapped on the basis of composition provided by the invention specifically, the present invention provides a kind of tablet to relax bowel
Include adhesive, disintegrant, lubricant and filler.
Wherein：
The adhesive can be selected from one kind in starch slurry, gelatin solution, sodium cellulose glycolate, hydroxypropyl cellulose
Or it is several.In the raw material of the tablet, the dosage of described adhesive is preferably 0.01~6 part.
It is fine that the disintegrant can be selected from dried starch, Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose sodium, crosslinking methylol
One or more of plain sodium of dimension.In the raw material of the tablet, the dosage of the disintegrant is preferably 0.01~6 part.
The lubricant can be selected from magnesium stearate, talcum powder, superfine silica gel powder, hydrogenated vegetable oil, one or more of.?
In the raw material of the tablet, the dosage of the lubricant is preferably 0.01~1 part.
The filler can be selected from one or more of starch, dextrin, mannitol, antierythrite, microcrystalline cellulose.?
In the raw material of the tablet, the dosage of the filler is preferably 0.5~8 part.
As the present invention a kind of specific embodiment, the tablet using the composition as active ingredient, further include as
The auxiliary material of lower parts by weight：
As a kind of preferred embodiment of the present invention, the tablet is using the composition as active ingredient, also
Include the auxiliary material of following parts by weight：
Present invention simultaneously provides the preparation methods of above-mentioned tablet, specifically comprise the following steps：By the composition first with fill out
Fill agent, disintegrant is uniformly mixed, and is added adhesive and is uniformly mixed, it is dry after whole grain, it is uniform to add mix lubricant, tabletting
Tablet is made.
The specific raw material of Scheme Choice provided by the invention can play effect that is synergistic, mitigating toxic side effect, make
Constipation can effectively be treated and prevented by obtaining the composition of gained, and great side is provided to the patient perplexed for a long time by constipation
It helps.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 0.5kg, Siraitia grosvenorii
3kg, campanulaceae 10kg.
The present embodiment provides the preparation method of the composition simultaneously, specially：
(1) folium sennae is taken, is impregnated with 70% ethanol water of 4 times of volumes after crushing, ultrasonic extraction 30 minutes, separation
Supernatant, concentration are 2 with lemon acid for adjusting pH, and stirring, centrifugation, extracting yellow sediment fraction take appropriate purified water to wash, and collect
Precipitation, obtains alcohol extract；
(2) remaining raw material is mixed, the water of 1/2 volume is added, decocted, filter to take supernatant, concentrated, obtain water extract；
(3) alcohol extract is dried in vacuo at 40 DEG C, the water extract is spray-dried, desciccate is mixed, i.e.,
?.
Embodiment 2
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 2.5kg, Siraitia grosvenorii
10kg, campanulaceae 0.5kg.The preparation method is the same as that of Example 1.
Embodiment 3
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 6kg, Siraitia grosvenorii 2kg,
Campanulaceae 5kg.The preparation method is the same as that of Example 1.
Embodiment 4
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 2kg, Siraitia grosvenorii 2kg,
Campanulaceae 3.6kg, rde bean 2kg, lily 7kg.
Embodiment 5
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 0.2kg, Siraitia grosvenorii
3kg, campanulaceae 0.3kg, rde bean 12kg, lily 1kg.
Embodiment 6
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 1kg, Siraitia grosvenorii 2kg,
Campanulaceae 3kg, rde bean 4kg, lily 6kg.
Embodiment 7
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 0.7kg, Siraitia grosvenorii
0.2kg, campanulaceae 1kg, rde bean 8kg, lily 5kg.
Embodiment 8
A kind of composition to relax bowel is present embodiments provided, raw material group becomes：Folium sennae 1.5kg, Siraitia grosvenorii
2kg, campanulaceae 0.4kg, rde bean 9kg, lily 2kg.
Embodiment 9
A kind of tablet to relax bowel is present embodiments provided, raw material group becomes：The composition that embodiment 1 provides, hydroxyl
Sodium carboxymethylcellulose pyce 0.25kg, dried starch 0.75kg, magnesium stearate 0.05kg, microcrystalline cellulose 0.5kg.
The present embodiment provides the preparation method of the tablet simultaneously, specially：By the composition and filler, disintegration
Agent is uniformly mixed, and is added adhesive and is uniformly mixed, and after the drying of wet grain, whole grain adds that mix lubricant is uniform, and tabletting is made
Tablet.
Embodiment 10
A kind of tablet to relax bowel is present embodiments provided to differ only in compared with Example 9：It is carried with embodiment 2
The composition of confession is as active ingredient.
Embodiment 11
A kind of tablet to relax bowel is present embodiments provided to differ only in compared with Example 9：It is carried with embodiment 3
The composition of confession is as active ingredient.
Embodiment 12
A kind of tablet to relax bowel is present embodiments provided to differ only in compared with Example 9：It is carried with embodiment 4
The composition of confession is as active ingredient.
Embodiment 13
A kind of tablet to relax bowel is present embodiments provided to differ only in compared with Example 9：It is carried with embodiment 5
The composition of confession is as active ingredient.
Embodiment 14
A kind of tablet to relax bowel is present embodiments provided to differ only in compared with Example 9：It is carried with embodiment 6
The composition of confession is as active ingredient.
Embodiment 15
A kind of tablet to relax bowel is present embodiments provided to differ only in compared with Example 9：It is carried with embodiment 7
The composition of confession is as active ingredient.
Embodiment 16
A kind of tablet to relax bowel is present embodiments provided to differ only in compared with Example 9：It is carried with embodiment 8
The composition of confession is as active ingredient.
Comparative example 1
This comparative example provides a kind of tablet to relax bowel and differs only in compared with Example 9：Without using arhat
Fruit.
Comparative example 2
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 12：Without using arhat
Fruit and campanulaceae.
Comparative example 3
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 12, the composition
Preparation method be：
Whole raw materials including folium sennae are mixed, the water of 1/2 volume is added, decocts, filters to take supernatant, it is dense
Contracting, spray drying to get.
Comparative example 4
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 12, the composition
Preparation method be：
(1) folium sennae is taken, is impregnated with 95% ethanol water of 4 times of volumes after crushing, ultrasonic extraction 30 minutes, separation
Supernatant, concentration, does not adjust pH value and directly stirs, centrifuges, extracting yellow sediment fraction, and appropriate purified water is taken to wash, and collects precipitation,
Obtain alcohol extract；
Step (2), (3) with composition in embodiment 12 preparation method.
Comparative example 5
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 12：It will be in composition
Raw material folium sennae replace with rheum officinale.
Comparative example 6
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 13：It will be in composition
Raw material folium sennae replace with rheum officinale.
Comparative example 7
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 14：It will be in composition
Raw material folium sennae replace with rheum officinale.
Comparative example 8
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 15：It will be in composition
Raw material folium sennae replace with rheum officinale.
Comparative example 9
This comparative example provides a kind of tablet to relax bowel and is differed only in compared with embodiment 16：It will be in composition
Raw material folium sennae replace with rheum officinale.
Experimental example
The tablet that this experimental example provides the various embodiments described above and comparative example comments the therapeutic effect to relax bowel
Valence.
Choose every group of 40 people of patient for being diagnosed as constipation.Meet following standard for examination person, 1. the constipation course of disease is more than 6 months,
There is paresthesia epilepsy within nearest 3 months；2. the age is more than 16 years old, it is less than 80 years old person；3. patient signs informed consent form, voluntary participation sheet
Research.
Every for examination person according to 1g/ times, each primary metering is taken daily morning and evening takes each embodiment and comparison respectively
The tablet that example provides.
Constipation clinical score:1. autonomous defecation:There is (0 point), by drug, hand assisted or bowel lavage defecation (3 points)；2. awareness of defecation
Sense:Have (0 point), without (1 point)；3. voluntarily stool interval:Defecation was primary (0 point) on 1st~2, and defecation was primary (1 point) on 3rd~4,5~
Defecation on the 6th is primary (2 points), and defecation is primary (3 points) within 6 days or more, cannot voluntarily defecation (4 points)；4. defecation effort:Naturally it arranges
Just, no defecation is laborious (0 point), and must exert oneself defecation (1 point), exerts that earn can defecation (2 points)；5. each defecation time:1~10min
(0 point), 11~20min (1 point), 21~30min (2 points), 30min or more (3 points)；6. just matter:Lump is dispersed in (3 points), lump
At item (2 points), there is crackle (1 point) in item, it is soft (0 point) at item light；7. abdominal distension, abdominal pain, defecation are felt not to the utmost, rectal tenesmus sense, anus
Door sense of obstruction is vented unsmooth sense 6 symptoms with without (0 point), slight (1 point), and obviously (2 points), unbearably 4 grades of (3 points) score.
Efficacy assessment standard《New Chinese medicine guideline of clinical investigations》, and clinic is combined, it is commented from following primary symptom curative effect is intended
Price card is accurate:1. clinical recovery:Primary symptom disappears, and defecation is normal, and constipation clinical symptoms integral is 0；2. effective:Clinical symptoms obviously change
Kind, clinical symptoms integral reduces >=2/3 before relatively treating；3. effectively:Clinical symptoms improve, but clinical symptoms integral reduction by 1/2~
2/3；4. improving:Clinical symptoms improve, but clinical symptoms integral relatively treats preceding reduction≤1/2；5. invalid:Clinical symptoms without
Improve or aggravate, clinical symptoms integral is without reduction or increases instead.
The effect for the tablet that embodiment 9~16 provides is as shown in table 1.
Table 1：Therapeutic effect of the tablet that each embodiment provides for constipation patient
The above results to constipation using the tablet that composition provided by the invention is prepared it is found that have good treatment
Effect can play synergistic function between each active ingredient.
The effect for the tablet that comparative example 1~4 provides is as shown in table 2.
Table 2：Therapeutic effect of the tablet that comparative example 1~4 provides for constipation patient
For the advantages of the present invention is further explained, main component folium sennae is substituted for by this experimental example equally has ease constipation to lead to
Just effect rheum officinale (rheum officinale be the perennial plant of a variety of polygonaceae Rheums be collectively referred to as and the title of Chinese medicine.Rheum officinale has
Purgating heat and bowels effect, for Gastrointestinal excess heat, stagnant, constipation, abdomen turgor, pain with tenderness or even hyperpyrexia, coma are raved
Language, such as dachengqi decoction；Or the cold accumulation and constipation of spleen sun deficiency, such as wenpi decoction) other compositions are constant, and as a comparison case 5~9, it goes forward side by side
Pedestrian's body proof test proves beneficial effects of the present invention deeper into ground.Effect such as 3 institute of table for the tablet that comparative example 5~9 provides
Show.
Table 3：Therapeutic effect of the tablet that comparative example 5~9 provides for constipation patient
Known to the above results：Lack folium sennae in being such as formulated, although the equally rheum officinale with functions of loosening bowel relieving constipation is added,
Last effective percentage is well below the embodiment for using folium sennae.
Although above having used general explanation, specific implementation mode and experiment, the present invention is made to retouch in detail
It states, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Range.
Claims (10)
1. a kind of composition to relax bowel, which is characterized in that in parts by weight, using the raw material preparation including following ingredient
At：
0.01~6 part of folium sennae；
0.01~15 part of Siraitia grosvenorii；
0.1~10 part of campanulaceae.
2. composition according to claim 1, which is characterized in that use includes that the raw material of following ingredient is prepared：
0.2~6 part of folium sennae；
0.2~10 part of Siraitia grosvenorii；
0.3~10 part of campanulaceae；
Preferably, it is prepared using the raw material including following ingredient：
0.2~2 part of folium sennae；
0.2~3 part of Siraitia grosvenorii；
0.3~3.6 part of campanulaceae；
It is highly preferred that the raw material that use includes following ingredient is prepared：
0.7~1.5 part of folium sennae；
0.2~2 part of Siraitia grosvenorii；
0.4~1 part of campanulaceae.
3. composition according to claim 1 or 2, which is characterized in that the raw material further includes 0.2~12 part of lily, excellent
It is selected as 1~7 part, more preferably 2~5 parts.
4. according to the composition described in claims 1 to 3 any one, which is characterized in that the raw material further includes rde bean 0.2
~30 parts, preferably 2~12 parts, more preferably 8~9 parts.
5. composition according to claim 1, which is characterized in that use includes that the raw material of following ingredient is prepared：
Preferably, it is prepared using the raw material including following ingredient：
It is highly preferred that the raw material that use includes following ingredient is prepared：
It is further preferred that the raw material that use includes following ingredient is prepared：
6. according to the composition described in Claims 1 to 5 any one, which is characterized in that using the method included the following steps
It is prepared：
(1) folium sennae is taken, is extracted with ethyl alcohol, alcohol extract is obtained；
(2) remaining raw material is taken, is extracted with water after mixing, obtains water extract；
(3) alcohol extract is mixed with water extract to get；
Preferably, step (3) is first respectively dried the alcohol extract and water extract, then is mixed.
7. composition according to claim 6, which is characterized in that the ethyl alcohol that step (1) uses for 70~75% ethyl alcohol
Aqueous solution；
Preferably, the step (1) is specially：Folium sennae is taken, is impregnated with 70~75% ethanol water after crushing, extraction,
Centrifuging and taking supernatant, concentration, after adjusting pH is 1.5~2.5, centrifuging and taking precipitation obtains alcohol extract.
8. the food that the composition described in claim 1~7 any one relaxes bowel in preparation prepares the health care to relax bowel
Application in the drug of food and/or preparation for preventing or treating constipation.
9. a kind of drug for preventing or treating constipation, which is characterized in that be combined described in Claims 1 to 5 any one
Object further includes following auxiliary material as active ingredient：Adhesive, disintegrant, lubricant and filler；
Preferably, further include the auxiliary material of following parts by weight：
It is highly preferred that further including the auxiliary material of following parts by weight：
It is further preferred that further including the auxiliary material of following parts by weight：
10. the method for preparing drug described in claim 9, which is characterized in that include the following steps：By the composition first with fill out
Fill agent and disintegrant to be uniformly mixed, add adhesive and be uniformly mixed, it is dry after whole grain, it is uniform to add mix lubricant,
Tabletting.
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| CN201810930637.9A CN108785366A (en) | 2018-08-15 | 2018-08-15 | A kind of composition to relax bowel and its application |
| HK18115480.5A HK1257803A1 (en) | 2018-08-15 | 2018-12-04 | A composition for improving intestinal tract and releasing the constipation and its application |
| TW108102309A TWI688399B (en) | 2018-08-15 | 2019-01-21 | Laxative composition and application thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810930637.9A Pending CN108785366A (en) | 2018-08-15 | 2018-08-15 | A kind of composition to relax bowel and its application |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN108785366A (en) |
| HK (1) | HK1257803A1 (en) |
| TW (1) | TWI688399B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0416163A (en) * | 1990-05-02 | 1992-01-21 | Nippon Synthetic Chem Ind Co Ltd:The | Intestine-controlling composition |
| CN104587312A (en) * | 2015-02-15 | 2015-05-06 | 孙红梅 | Traditional Chinese medicine composition for treating constipation |
| CN104958646A (en) * | 2015-07-28 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese medicinal preparation for relaxing bowels and preparation method thereof |
| CN107594297A (en) * | 2016-07-12 | 2018-01-19 | 李振祥 | A kind of five cereals are relieved summer heat congee |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101507792B (en) * | 2009-03-27 | 2010-12-29 | 刘玉梅 | Chinese patent medicine preparation capable of treating elderly constipation |
-
2018
- 2018-08-15 CN CN201810930637.9A patent/CN108785366A/en active Pending
- 2018-12-04 HK HK18115480.5A patent/HK1257803A1/en unknown
-
2019
- 2019-01-21 TW TW108102309A patent/TWI688399B/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0416163A (en) * | 1990-05-02 | 1992-01-21 | Nippon Synthetic Chem Ind Co Ltd:The | Intestine-controlling composition |
| CN104587312A (en) * | 2015-02-15 | 2015-05-06 | 孙红梅 | Traditional Chinese medicine composition for treating constipation |
| CN104958646A (en) * | 2015-07-28 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese medicinal preparation for relaxing bowels and preparation method thereof |
| CN107594297A (en) * | 2016-07-12 | 2018-01-19 | 李振祥 | A kind of five cereals are relieved summer heat congee |
Non-Patent Citations (4)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 30 June 2014, 上海科学技术出版社 * |
| 方亮: "《药剂学》", 31 March 2016, 中国医药科技出版社 * |
| 杨玉琴: "正交试验法优选番泻叶醇提工艺", 《河北中医》 * |
| 聂宏: "《中医食疗药膳学》", 31 August 2017, 西安交通大学出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| TW202009006A (en) | 2020-03-01 |
| HK1257803A1 (en) | 2019-11-01 |
| TWI688399B (en) | 2020-03-21 |
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