CN104324184A - Traditional Chinese medicine composition for treating irregular menstruation and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating irregular menstruation and preparation method of traditional Chinese medicine composition Download PDF

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CN104324184A
CN104324184A CN201410595112.6A CN201410595112A CN104324184A CN 104324184 A CN104324184 A CN 104324184A CN 201410595112 A CN201410595112 A CN 201410595112A CN 104324184 A CN104324184 A CN 104324184A
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herba
chinese medicine
medicine composition
menoxenia
parts
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张立
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention relates to a traditional Chinese medicine composition for treating irregular menstruation and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: fructus viticis, Chinese brake herb, Chinese lizardtail rhizome or herb, yerbadetajo herb, motherwort herb, Chinese angelica, Szechuan lovage rhizome, white paeony root, nutgrass galingale rhizome, Indian mockstrawberry herb and hairyvein agrimonia herb and bud. The traditional Chinese medicine composition has the effects of regulating menstruation and relieving pain, can effectively improve various discomfortable symptoms of irregular menstruation and has a relatively good curative effect on the irregular menstruation.

Description

A kind of Chinese medicine composition for the treatment of menoxenia and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of menoxenia and preparation method thereof.
Background technology
Menoxenia, also claims menoxenia.This is a kind of common gynaecopathia.Show as the exception of menstrual cycle or amount of bleeding, or the moon is premenstrual, menstrual period time stomachache and General Symptoms.Under normal circumstances, 3-7 days menstrual period, through blood volume 50-100 milliliters.Between menstrual period, due to the change of organism endocrine function, the irritability of brain reduces, and make immunologic function degression in body, the resistance against diseases of whole body weakens, and is thus easily subject to the impact of extraneous unfavorable factor and various disease occurs.
Hematopathy, hypertension, endocrine disturbance, miscarriage, ectopic pregnancy, hydatidiform mole, hyperprolactinemia, ovarian tumor, hysteromyoma, adenosis of breast, tuberculosis of fallopian tube, endometrial tuberculosis, chronic endometritis, chronic salpingo-ocphoritis etc. all can cause menoxenia.Extraneous factor is as mood disorders, cold stimulation, also can cause menoxenia addicted to tobacco and wine, electromagnetic wave etc.
Menoxenia is the modal a kind of disease of gynecological.The traditional Chinese medical science thinks all diseases caused by exogenous pathogenic factor six climate exopathogens, internal damage by the excessive seven emotions and sexual overstrain, improper diet and overtiredness, or by the impact of other diseases, all can cause menoxenia.
The Syndrome Differentiation of Traditional Chinese Medicine of menoxenia and method for making:
1, blood-heat type
Symptom: menoxenia, red or have purple block or dark red through color, matter is sticky and thick, and ambition is unhappy, flushing xerostomia, dry mouth and throat, Blushing, yellowish urine constipation, red tongue with yellow fur.
Treatment: should clearing away heat and cooling blood.
2, type of depressed liver and heat transmission
Symptom: menoxenia, blockage of menstruation, breast side of body breast and lower abdominal distention pain, does not uncomfortable in chestly relax, irritable or kindly to sigh, and eructation and poor appetite is red or purple through color, tongue tip side of red, bitter taste in the mouth and dry throat, yellow and thin fur.
Treatment: dispersing the stagnated live-QI to relieve the stagnation of QI heat clearing away.
3, qi-deficiency type
Symptom: advanced menstrual period, or menostaxis, the light matter of amount polychrome is rare clearly, and Mental fatigue limb is soft weak, shortness of breath and palpitation, anorexia and loose stool, empty and bearing-down sensation of the lower abdomen, pale tongue with thin fur.
Treatment: hemostasis by invigorating QI.
4, blood-deficiency type
Symptom: delayed menstrual cycle, the few color of amount is talked, and matter is rare clearly, dizziness and blurred vision, and cardiopalmus is seized with terror swollen, little sleep disturbed by dreams, and shallow complexion is simple and unadorned, the few tongue of light red tongue.
Treatment: blood yiqi.
5, blood-cold type
Symptom: menstrual period are delayed, color is secretly measured few, cold and pain in the lower abdomen, hot, to subtract, or aversion to cold and cold limbs, pale complexion, thin white fur of tongue.
Treatment: expelling pathogenic cold by warming the meridian.
6, Qi-stagnation type
Symptom: menstruation is delayed, the few color of amount secretly has block, and little abdominal distention is even pain, and breast coerces distending pain of the breast, dark tongue quality.
Treatment: vital energy regualting and blood circulation-promoting.
7, blood stasis type
Symptom: postponed menstruation, or few through carrying out amount, color is purple blackly has block, lower abdominal distention pain tenderness, or twinge, clot discharge after its alleviation of pain light, purplish tongue or have petechia ecchymosis.
Treatment: blood circulation promoting and blood stasis dispelling.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of menoxenia;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method for the treatment of menoxenia.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition for the treatment of menoxenia of the present invention, it is prepared from by the raw material comprising following weight portion:
White leeward 30-50 part, Herba Pteridis Multifidae 25-40 part, Rhizoma Saururi (Herba Saururi) 15-30 part, Herba Ecliptae 5-15 part, Herba Leonuri 10-30 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 3-10 part, Radix Paeoniae Alba 8-20 part, Rhizoma Cyperi 5-10 part, Herba Duchesneae Indicae 20-40 part, Herba Agrimoniae 5-15 part.
Preferably, be prepared from by the raw material comprising following weight portion:
White leeward 35-45 part, Herba Pteridis Multifidae 30-35 part, Rhizoma Saururi (Herba Saururi) 20-25 part, Herba Ecliptae 8-12 part, Herba Leonuri 15-25 part, Radix Angelicae Sinensis 8-12 part, Rhizoma Chuanxiong 5-8 part, Radix Paeoniae Alba 10-15 part, Rhizoma Cyperi 7-9 part, Herba Duchesneae Indicae 25-35 part, Herba Agrimoniae 8-12 part.
More excellent, be prepared from by the raw material comprising following weight portion:
Leeward 40 parts in vain, Herba Pteridis Multifidae 32 parts, Rhizoma Saururi (Herba Saururi) 23 parts, Herba Ecliptae 10 parts, Herba Leonuri 20 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Chuanxiong 6 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Cyperi 7 parts, Herba Duchesneae Indicae 30 parts, Herba Agrimoniae 10 parts.
Below the crude drug source of Chinese medicine composition of the present invention:
Leeward in vain, root, leaf, the flower of narrow leaf Herba Buddlejae Lindleyanae Buddleia asiatica Lour..Belong to 72 wind under classics Herba Achnatheri Inebriantis class of Yao nationality medicine.Acrid in the mouth, hardship, warm in nature.Dispelling, collateral-activating, dissipating blood stasis for subsidence of swelling, promoting the circulation of QI to relieve pain, preventing phlegm from forming and stopping coughing, refutes bone, hemostasis, removing damp to relieve itching, putrefaction removing and tissue regeneration promoting.Wind syndrome of head pain after tradition is applied to and manages property, cold syndrome of the stomach pain, rheumatic arthritis, icterohepatitis, metrorrhagia, puerperal hemorrhage too much, vomiting, splenasthenic abdominal distention, dysentery, abdominal pain due to worm stagnation, fishbone bone stuck in the throat, asthma, traumatic injury, erysipelas, otitis media, traumatic hemorrhage, burn and scald, eczema, innominate toxic swelling.
Herba Pteridis Multifidae is the herb of Pteridaceae plant Herba Pteridis Multifidae Pteris multifida Poir..Light, micro-hardship, cool.Clearing away heat-damp and promoting diuresis, removing toxic substances dysentery relieving, cooling blood for hemostasis.For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage is controlled in external, burn and scald.
Rhizoma Saururi (Herba Saururi) is dry rhizome or the herb of Saururaceae plant Rhizoma Saururi (Herba Saururi) Saururus chinensis (Lour.) Baill..Sweet, pungent, cold.Return lung, urinary bladder channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For dysuria, drench the puckery pain of drop, leucorrhea, urinary tract infection, oedema due to nephritis; External treatment sore swollen toxin, eczema.
Herba Ecliptae is the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..Sweet, sour, cold.Return kidney, Liver Channel.Nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Herba Leonuri is the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Bitter, pungent, be slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Chuanxiong is samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Paeoniae Alba, the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Bitter, sour, be slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Rhizoma Cyperi is the dry rhizome of sedge dried tuber Cyperus rotundus L..Pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Herba Duchesneae Indicae, Rosaceae Herba Duchesneae Indicae platymiscium Herba Duchesneae Indicae Duchesnea indica (Andr.) Focke, with all herbal medicine.Sweet, sour, cold.Slightly poisonous.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For cold, fever, cough, infantile hyperpyrexia infantile convulsion, laryngopharynx swelling and pain, diphtheria, icterohepatitis, bacillary dysentery, amebic dysentery, menorrhagia; Parotitis is controlled in external, venom, eye conjunctivitis, furuncle swelling toxin, herpes zoster, eczema.Also curing cancers can be tried.And can be used for killing wriggler, fly larvae.
Herba Agrimoniae is the dry aerial parts of rosaceous plant Radix Agrimoniae Agrimonia pilosa Ledeb..Bitter, puckery, flat.GUIXIN, Liver Channel.Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.Concrete preparation method is as follows:
Scheme one: get whole 11 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme two: get whole 11 taste medical materials, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme three: get whole 11 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The Chinese medicine for the treatment of menoxenia of the present invention, with pharmaceutically acceptable carrier combination, can also make various oral formulations, as tablet, capsule, oral liquid, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 4: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
Method 5: oral liquid
Get one of scheme one to scheme three gained active component, dissolve after-purification, concentrate, add oral liquid and commonly use adjuvant, production method is prepared into oral liquid of the present invention routinely.
Above-mentioned oral liquid is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Multiple formulations with reference to modern pharmacological research achievement, through test for many years, is screened, be have found the Chinese medicine formula effectively treating menoxenia by the applicant on the basis of research tradition tcm syndrome differentiation and treatment.
Chinese medicine composition effective ingredient disclosed in this invention is by leeward, Herba Pteridis Multifidae, Rhizoma Saururi (Herba Saururi), Herba Ecliptae, Herba Leonuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Cyperi, Herba Duchesneae Indicae, Herba Agrimoniae are prepared from vain.Fang Zhongbai is leeward is one of 72 wind common in strong precious jade medicine, and gynecology is usually used in metrorrhagia, and puerperal hemorrhage is too much; Herba Pteridis Multifidae clearing away heat-damp and promoting diuresis, can be used for leucorrhea, the treatment of metrorrhagia; Rhizoma Saururi (Herba Saururi) heat-clearing and toxic substances removing; Herba Ecliptae nourishing the liver and kidney, cooling blood for hemostasis; Herba Leonuri promoting blood flow to regulate menstruation is the first key medicine of menoxenia; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving; Rhizoma Chuanxiong blood-activating and qi-promoting, for menoxenia, amenorrhea dysmenorrhea; Radix Paeoniae Alba nourishing blood for regulating menstruation; Rhizoma Cyperi menstruction regulating and pain relieving; Herba Duchesneae Indicae heat-clearing and toxic substances removing; Herba Agrimoniae astringing to arrest bleeding, gynecological is used for metrostaxis, pudendal pruritus leukorrhagia.Full side works in coordination with mutually, has the effect of menstruction regulating and pain relieving, has good therapeutic effect to menoxenia.
  
A kind of Chinese medicine composition for the treatment of menoxenia provided by the invention has the following advantages:
1, composite preparation provided by the invention is safe and effective, has the effect of menstruction regulating and pain relieving, has good therapeutic effect to menoxenia.
2, prove through clinical trial, patient is after traditional Chinese medicine composition for treating of the present invention, and the total effective rate of menoxenia patient reaches 91.5%, and compares before each symptom and treatment after treatment, is all significantly improved.
3, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, and mouthfeel is good, and cost is low.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 oral liquid
Take white leeward 3kg, Herba Pteridis Multifidae 2.5kg, Rhizoma Saururi (Herba Saururi) 1.5kg, Herba Ecliptae 0.5kg, Herba Leonuri 1kg, Radix Angelicae Sinensis 0.5kg, Rhizoma Chuanxiong 0.3kg, Radix Paeoniae Alba 0.8kg, Rhizoma Cyperi 0.5kg, Herba Duchesneae Indicae 2kg, Herba Agrimoniae 0.5kg.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds adjuvant mannitol, sorbic acid, water stirs in extractum, subpackage, obtained oral liquid.
Embodiment 2 tablet
Take white leeward 5kg, Herba Pteridis Multifidae 4kg, Rhizoma Saururi (Herba Saururi) 3kg, Herba Ecliptae 1.5kg, Herba Leonuri 3kg, Radix Angelicae Sinensis 1.5kg, Rhizoma Chuanxiong 1kg, Radix Paeoniae Alba 2kg, Rhizoma Cyperi 1kg, Herba Duchesneae Indicae 4kg, Herba Agrimoniae 1.5kg.With 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3 granule
Take white leeward 3.5kg, Herba Pteridis Multifidae 3kg, Rhizoma Saururi (Herba Saururi) 2kg, Herba Ecliptae 0.8kg, Herba Leonuri 1.5kg, Radix Angelicae Sinensis 0.8kg, Rhizoma Chuanxiong 0.5kg, Radix Paeoniae Alba 1kg, Rhizoma Cyperi 0.7kg, Herba Duchesneae Indicae 2.5kg, Herba Agrimoniae 0.8kg.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 4 capsule
Take white leeward 4.5kg, Herba Pteridis Multifidae 3.5kg, Rhizoma Saururi (Herba Saururi) 2.5kg, Herba Ecliptae 1.2kg, Herba Leonuri 2.5kg, Radix Angelicae Sinensis 1.2kg, Rhizoma Chuanxiong 0.8kg, Radix Paeoniae Alba 1.5kg, Rhizoma Cyperi 0.9kg, Herba Duchesneae Indicae 3.5kg, Herba Agrimoniae 1.2kg.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, in extractum, add supplementary product starch, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method.
Embodiment 5 tablet
Take white leeward 4kg, Herba Pteridis Multifidae 3.2kg, Rhizoma Saururi (Herba Saururi) 2.3kg, Herba Ecliptae 1kg, Herba Leonuri 2kg, Radix Angelicae Sinensis 1kg, Rhizoma Chuanxiong 0.6kg, Radix Paeoniae Alba 1.2kg, Rhizoma Cyperi 0.7kg, Herba Duchesneae Indicae 3kg, Herba Agrimoniae 1kg.Extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 6 granule
Take white leeward 3.8kg, Herba Pteridis Multifidae 2.8kg, Rhizoma Saururi (Herba Saururi) 1.8kg, Herba Ecliptae 0.6kg, Herba Leonuri 2.3kg, Radix Angelicae Sinensis 1.3kg, Rhizoma Chuanxiong 0.4kg, Radix Paeoniae Alba 1.8kg, Rhizoma Cyperi 0.6kg, Herba Duchesneae Indicae 3.8kg, Herba Agrimoniae 0.6kg.Extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 7 syrup
Take white leeward 4.2kg, Herba Pteridis Multifidae 3.8kg, Rhizoma Saururi (Herba Saururi) 2.8kg, Herba Ecliptae 1.4kg, Herba Leonuri 2.8kg, Radix Angelicae Sinensis 0.6kg, Rhizoma Chuanxiong 0.6kg, Radix Paeoniae Alba 0.9kg, Rhizoma Cyperi 0.7kg, Herba Duchesneae Indicae 2.8kg, Herba Agrimoniae 0.7kg.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 8 mixture
Take white leeward 3.2kg, Herba Pteridis Multifidae 3kg, Rhizoma Saururi (Herba Saururi) 1.5kg, Herba Ecliptae 1.3kg, Herba Leonuri 1.2kg, Radix Angelicae Sinensis 1kg, Rhizoma Chuanxiong 0.7kg, Radix Paeoniae Alba 1.2kg, Rhizoma Cyperi 0.9kg, Herba Duchesneae Indicae 3.2kg, Herba Agrimoniae 0.9kg.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, filtrate is concentrated into 3 times that gross weight is medical material gross weight, fill, add mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, obtained mixture.
Embodiment 9 powder
Take white leeward 3kg, Herba Pteridis Multifidae 2.8kg, Rhizoma Saururi (Herba Saururi) 3kg, Herba Ecliptae 1.2kg, Herba Leonuri 2kg, Radix Angelicae Sinensis 1.2kg, Rhizoma Chuanxiong 0.5kg, Radix Paeoniae Alba 1.8kg, Rhizoma Cyperi 0.8kg, Herba Duchesneae Indicae 2.2kg, Herba Agrimoniae 1.4kg.Pulverize, sieve, to obtain final product.
clinical trial
one, to the clinical observation of menoxenia disease
1 diagnostic criteria is according to " guideline of clinical investigations of new Chinese medicine " and " Shanghai City Chinese medical disease conventional treatment ".
1.1 inclusive criterias meet menoxenia diagnosis and TCM syndrome diagnosis person: 1. preceeded menorrhea; 2. delayed menstrual cycle; 3. menstruation irregularly successively; 4. hypomenorrhea; 5. menorrhagia; 6. Western medicine diagnose is ovalatory dysfunctional uterine bleeding person.
The menoxenia person that 1.2 exclusion standards cause for genitals's organic disease (hysteromyoma, adenomyosis, pituitary tumor etc.) on inspection; Be associated with severe primary disease and the psychotics such as cardiovascular, liver, kidney and hemopoietic system; Allergic constitution or to multi-medicament allergy sufferers.
2 physical data
Meet above-mentioned standard patient 120 example, age 12-40 year, average 28 years old, the course of disease 3 months-2 years.All carry out B ultrasonic, gynecologial examination and vaginal secretions routine examination during patient assessment, result prompting has no organic disease, and all patients all meet the diagnostic criteria of menoxenia.
3 Therapeutic Method
All patients take the tablet of the embodiment of the present invention 5, each 2, every day 2 times, and a point morning and evening respectively takes 1 time, treats 3 menstrual cycle, during taking this product, withdraws all other steroid hormones, and prohibits the food taking pungent dry raw food.
4 clinical efficacy standards are formulated with reference to " guideline of clinical investigations of new Chinese medicine ".
4.1 curative effect of disease judge recovery from illness: menstrual cycle, through amount, recover normal, other transference cures menstrual period, and integration reduces >=95%; Effective: menstrual cycle recovers (28 ± 7) sky, menorrhagia person, before amount comparatively treatment, reduce 1/3 or be less than 100ml, menstrual period recovered within 7 days, other transference cures or alleviate, integration minimizing >=70%; Effective: treat rear menstrual cycle, menstrual period, alleviate before amount comparatively treatment, integration reduces >=30%; Invalid: to treat rear menstrual cycle, through measuring, menstrual period, integration reduced <30% without improvement.
4.2 hemostatic healing efficacies judge recovery from illness: stop in vaginal hemorrhage 3-5 days after treatment, recover normal through amount; Effective: to stop in the per vaginam course for the treatment of hemorrhage 5-10 days after treatment, minimizing 1/3 or be less than 100ml before amount comparatively treatment; Effective: treatment after vaginal hemorrhage within more than 10 days, stop, menstrual cycle, through amount all make moderate progress; Invalid: treatment after vaginal hemorrhage stop, the cycle, through amount be not improved.
4.3 regulating menstruation efficacy determinations recoveries from illness: after treatment, menstruation menstrual period recover normal are menstrual cycle, all normal through amount; Effective: after treatment, menstruation menstrual period recover normal, menstrual cycle, normal through measuring; Effective: after treatment through the phase shorten, the cycle, through amount change to some extent; Invalid: after treatment through the phase, the cycle, through measure all without change.
4.4 standards of grading are marked according to " guideline of clinical investigations of new Chinese medicine " Syndrome Scale quantization table and 3 point-scores, comprising symptom quantization modulation such as spiritlessness and weakness, deficiency of QI with disinclination to talk, lumbosacral aching pain, dysmenorrhea, distending pain of the breast, symptom the lighter is 1 point, in symptom, person is 2 points, severe symptom is 3 points, and compares symptom integral before and after treatment.
5 results
5.1 clinical efficacies are fully recovered 44 examples (36.7%), and effective 45 examples (37.5%), effective 22 examples (18.3%), no effect 9 (7.5%), total effective rate reaches 92.5%.Treatments period has no other untoward reaction.
3.2 appraisal result are in table 1
Patients Before And After symptom score change (`x ± s divides) treated by table 1
n Lower abdominal distention pain Lumbosacral aching pain Lassitude Distending pain of the breast Spiritlessness and weakness Deficiency of QI with disinclination to talk Dizziness and blurred vision Cardiopalmus Aversion to cold and cold limbs Dysphoria with feverish sensation in the chest palms and soles
Before treatment 120 118.4±38.9 159.6±77.4 121.8±29.6 174.9±36.4 122.5±22.1 166.3±30.6 133.7±37.2 140.8±23.4 96.6±45.9 138.5±26.6
After treatment 120 52.9±11.7 * 43.5±18.6 * 30.9±12.8 * 36.1±20.4 * 55.3±17.5 * 31.2±18.2 * 41.1±18.2 * 33.6±12.5 * 45.4±16.8 * 38.9±12.5 *
Note, compares with before treatment, * P < 0.05.
As shown in Table 1, after the treatment of 3 menstrual cycle, the present invention is 92.5% to the effective percentage of menoxenia, and compares before each symptom and treatment after treatment, is all significantly improved.Result shows: Chinese medicine composition of the present invention has good therapeutical effect to menoxenia.
model case
Old XX, female, 46 years old.Main suit's nearly in menoxenia, 18-20 days tides, go through 8-10 days totally, 2-4 days menstrual period are many through measuring, color is light red, time hold clot under the arm, pale complexion, spiritlessness and weakness, dizziness, soreness of waist pain, without stomachache, tastelessness, indigestion and loss of appetite, frequent urination at night, defecates rotten, pale tongue is fat has tooth to print, white and thin fur, deep-thready pulse, examine as menoxenia, through taking the embodiment of the present invention 6 granule 3 months, menstruation recovers normal substantially.
Woods XX, female, 31 years old.Main suit's delayed menstrual cycle, amount is few, and many 40-70 sky one tide, goes through 2 days totally, with napkin 45, do not drench, dizzy weak, cardiopalmus, the soreness of waist, shallow complexion is dark dim, pale tongue, white and thin fur, thready pulse, checks endocrine five prompting premature ovarian failure, examines as menoxenia (very few).Through taking the embodiment of the present invention 4 capsule 6 months, menstrual cycle recovers normal, through amount showed increased, goes through 4-5 days totally, and with napkin 10, check endocrine five is normal.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (8)

1. treat a Chinese medicine composition for menoxenia, it is characterized in that it is made up of the raw material comprising following weight portion:
White leeward 30-50 part, Herba Pteridis Multifidae 25-40 part, Rhizoma Saururi (Herba Saururi) 15-30 part, Herba Ecliptae 5-15 part, Herba Leonuri 10-30 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 3-10 part, Radix Paeoniae Alba 8-20 part, Rhizoma Cyperi 5-10 part, Herba Duchesneae Indicae 20-40 part, Herba Agrimoniae 5-15 part.
2. the Chinese medicine composition for the treatment of menoxenia as claimed in claim 1, is characterized in that it is made up of the raw material comprising following weight portion:
White leeward 35-45 part, Herba Pteridis Multifidae 30-35 part, Rhizoma Saururi (Herba Saururi) 20-25 part, Herba Ecliptae 8-12 part, Herba Leonuri 15-25 part, Radix Angelicae Sinensis 8-12 part, Rhizoma Chuanxiong 5-8 part, Radix Paeoniae Alba 10-15 part, Rhizoma Cyperi 7-9 part, Herba Duchesneae Indicae 25-35 part, Herba Agrimoniae 8-12 part.
3. the Chinese medicine composition for the treatment of menoxenia as claimed in claim 1, is characterized in that it is made up of the raw material comprising following weight portion:
Leeward 40 parts in vain, Herba Pteridis Multifidae 32 parts, Rhizoma Saururi (Herba Saururi) 23 parts, Herba Ecliptae 10 parts, Herba Leonuri 20 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Chuanxiong 6 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Cyperi 7 parts, Herba Duchesneae Indicae 30 parts, Herba Agrimoniae 10 parts.
4. the Chinese medicine composition of the treatment menoxenia as described in any one of claim 1-3, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. the Chinese medicine composition for the treatment of menoxenia as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 11 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
6. the Chinese medicine composition for the treatment of menoxenia as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 11 taste medical materials, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
7. treatment menoxenia as claimed in claim 4 Chinese medicine composition, it is characterized in that its active component is prepared from by the following method: get whole 11 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, alcohol content is made to be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtain active component.
8. treat a Chinese medicine composition for menoxenia, Chinese medicine composition and the pharmaceutically acceptable carrier combination of the treatment menoxenia according to any one of claim 1-3 are prepared from.
CN201410595112.6A 2014-10-30 2014-10-30 Traditional Chinese medicine composition for treating irregular menstruation and preparation method of traditional Chinese medicine composition Pending CN104324184A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107737328A (en) * 2017-12-06 2018-02-27 韦永朴 A kind of Chinese medicine composition for treating uterine bleeding and preparation method thereof
CN107823556A (en) * 2017-11-15 2018-03-23 广西博白县华春福家庭农场 A kind of Chinese medicine composition for treating irregular menstruation and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1814195A (en) * 2005-12-05 2006-08-09 杨雄志 Chinese medicine composition for treating gynecopathy and use thereof
CN102357170A (en) * 2011-10-18 2012-02-22 文登市口腔医院 Traditional Chinese medicine for treating qi stagnation and blood stasis type amenorrhea
CN103566119A (en) * 2012-08-03 2014-02-12 天津太平洋制药有限公司 Drug for treating irregular menstruation and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1814195A (en) * 2005-12-05 2006-08-09 杨雄志 Chinese medicine composition for treating gynecopathy and use thereof
CN102357170A (en) * 2011-10-18 2012-02-22 文登市口腔医院 Traditional Chinese medicine for treating qi stagnation and blood stasis type amenorrhea
CN103566119A (en) * 2012-08-03 2014-02-12 天津太平洋制药有限公司 Drug for treating irregular menstruation and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107823556A (en) * 2017-11-15 2018-03-23 广西博白县华春福家庭农场 A kind of Chinese medicine composition for treating irregular menstruation and preparation method thereof
CN107737328A (en) * 2017-12-06 2018-02-27 韦永朴 A kind of Chinese medicine composition for treating uterine bleeding and preparation method thereof

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Application publication date: 20150204