CN102552571A - Traditional Chinese medicine composition for treating urinary calculus, capsule, syrup and preparation method - Google Patents
Traditional Chinese medicine composition for treating urinary calculus, capsule, syrup and preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating urinary calculus. The traditional Chinese medicine composition comprises juncus roemerianus, rhizoma polygoni cuspidati, radix platycodonis, panax pseudoginseng, radix rubiae, fructus polygoni orientalis, cluster mallow fruit, herba plantaginis, radix stephaniae tetrandrae, radix adenophorae, fructus lycii, radix achyranthis bidentatae, radix paeoniae rubra, radix pulsatillae and senna leaf. The traditional Chinese medicine composition provided by the invention overcomes the shortcomings in treating urinary calculus at present; and with the precious traditional Chinese medicine knowledge and the traditional Chinese medicine resources of China, the invention provides a traditional Chinese medicine with little side effect, good curative effect, low cost and high cure rate and avoids disease relapse so as to realize a good effect in treating urinary calculus.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine that is used to treat urinary system calculus.
Background technology
It is to cause that residue is difficult to discharge in the urine owing to suffer from a deficiency of the kidney that urinary system calculus forms, and generates crystal, receives its damp and hot with the passing of time Cheng Shi that decocts; Or cause stagnation of QI blood stasis because of insufficiency of kidney-YANG and damp-heat accumulation, irritability stasis, damage cause the stasis of blood etc., and stasis of blood heat-transformation of a specified duration, heat is annotated bladder; The gasification function of kidney and bladder is not normal in addition; Heat decocts crystal Cheng Shi in the urine for a long time, is a kind of worldwide commonly encountered diseases, frequently-occurring disease, and its sickness rate is in rising trend.In recent years along with the continuous expansion of environmental pollution, the change of people's living habit, the patient of urinary system calculus is constantly increasing, and the treatment of primary disease is more and more come into one's own.
Be divided into renal calculus, ureteral calculus, vesical calculus again according to position, calculus place clinically, domestic sickness rate is higher.Primary disease is not in sending out, and is clinical how asymptomatic, or the slight vagoue pain of lumbus and abdomen is only arranged, hands and feet being not warm etc., and send out then has the prominent waist abdomen severe pain of doing like strand more, leads and few abdomen or hematuria or urethral irritation or sandstone discharge from urine.
Though existing at present multiple means is applied to clinical treatment, and obtains good result, mainly comprises medicine calculus and surgical calculus removing.The medicine calculus is anti-inflammatory analgetic to a certain extent, and the effect of relief of symptoms is arranged really, and the import medicine also can relief of symptoms, but all can not eradicate fully, thereby lithagogue effect is all not obvious.And the surgical calculus removing therapy is painful greatly with it, expense is high; General do not accepted and perform the operation and to eliminate the reason that forms calculus by the patient; Therefore as easy as rolling off a log recurrence regenerative stone after performing the operation; Many cases need operation once more, and take the lithotrite extracorporeal shock-wave lithotomy to cause the local mucous membrane major injury almost inevitable, and these factors all are unfavorable for the treatment of calculus.
Summary of the invention
Technical problem to be solved by this invention is; Overcome the deficiency of existing treatment urinary system calculus; Utilize China valuable Chinese medicine knowledge and Chinese medicine resource; Provide that a kind of side effect is little, good effect, cost is low, cure rate is high, the state of an illness repeatedly Chinese medicine not, thereby the treatment urinary system calculus is played good effect.
Ask in order to solve above-mentioned technology; The invention provides a kind of Chinese medicine composition that is used to treat urinary system calculus, it comprises: Medulla Junci, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Radix Notoginseng, Radix Rubiae, Fructus Polygoni Orientalis, Fructus Malvae, Herba Plantaginis, Radix Stephaniae Tetrandrae, Radix Adenophorae, Fructus Lycii, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra, the Radix Pulsatillae and Folium Sennae.
Wherein, The weight fraction of each component ratio does in the said Chinese medicine composition, 15～25 weight portion Medulla Juncies, 15～25 weight portion Rhizoma Polygoni Cuspidati, 5～10 weight portion Radix Platycodoniss, 20～30 weight portion Radix Notoginseng, 20～30 weight portion Radix Rubiaes, 20～30 weight parts water Fructus Carthami tinctoriis, 25～35 weight portion Fructus Malvae, 35～45 weight portion Herba Plantaginiss, 25～35 weight portion Radixs Stephaniae Tetrandrae, 50～70 weight portion Radix Adenophoraes, 65～80 weight portion Fructus Lycii, 20～30 weight portion Radix Achyranthis Bidentataes, 20～30 weight portion Radix Paeoniae Rubra, 15～25 weight portion Radix Pulsatillaes and 15～25 weight portion Folium Sennae.
Wherein, The weight fraction of each component ratio does in the said Chinese medicine composition, 20～25 weight portion Medulla Juncies, 20～25 weight portion Rhizoma Polygoni Cuspidati, 8～10 weight portion Radix Platycodoniss, 25～30 weight portion Radix Notoginseng, 25～30 weight portion Radix Rubiaes, 25～30 weight parts water Fructus Carthami tinctoriis, 30～35 weight portion Fructus Malvae, 40～45 weight portion Herba Plantaginiss, 30～35 weight portion Radixs Stephaniae Tetrandrae, 60～70 weight portion Radix Adenophoraes, 75～80 weight portion Fructus Lycii, 25～30 weight portion Radix Achyranthis Bidentataes, 25～30 weight portion Radix Paeoniae Rubra, 20～25 weight portion Radix Pulsatillaes and 20～25 weight portion Folium Sennae.
Wherein, the dosage form of said Chinese medicine composition can be granule, honey refining pill, drop pill, capsule, tablet, powder, decoct, syrup.
The capsule that the present invention also provides above-mentioned Chinese medicine composition to process, the method for preparing of said capsule comprise,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step went on foot the dry powder blend that obtains with the first step to the three, added excipient, disintegrating agent mixing, dry, pulverizing, added fluidizer; Or process particle drying, add lubricant; Or process micropill; In incapsulating at last, obtain capsule, said excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants; Described disintegrating agent is sodium carboxymethyl cellulose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Described fluidizer (lubricant) is that magnesium stearate, differential silica gel and other have the pharmaceutic adjuvant of fluidizer effect.Excipient, disintegrating agent, the weight content of fluidizer (lubricant) in medicine are:: 5～70%, 1～30%, 0.1～10%.
The syrup that the present invention also provides above-mentioned Chinese medicine composition to process, the method for preparing of said syrup comprise,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step; Dry powder blend with the first step to the three steps acquisition; Add water dissolution, regulate pH value to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently with 40% sodium hydroxide solution with respect to 2～3 times of mixture qualities; Promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
The present invention also provides the method for preparing of above-mentioned Chinese medicine composition, and when the dosage form of said Chinese medicine composition was capsule, it comprised,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step went on foot the dry powder blend that obtains with the first step to the three, added excipient, disintegrating agent mixing, dry, pulverizing, added fluidizer; Or process particle drying, add lubricant; Or process micropill; In incapsulating at last, obtain capsule, said excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants; Described disintegrating agent is sodium carboxymethyl cellulose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Described fluidizer (lubricant) is that magnesium stearate, differential silica gel and other have the pharmaceutic adjuvant of fluidizer effect.Excipient, disintegrating agent, the weight content of fluidizer (lubricant) in medicine are:: 5～70%, 1～30%, 0.1～10%.
The present invention also provides the method for preparing of above-mentioned Chinese medicine composition, and when the dosage form of said Chinese medicine composition was syrup, it comprised,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step; Dry powder blend with the first step to the three steps acquisition; Add water dissolution, regulate pH value to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently with 40% sodium hydroxide solution with respect to 2～3 times of mixture qualities; Promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
Beneficial effect of the present invention:
The present invention overcomes the deficiency of existing treatment urinary system calculus; Utilize China valuable Chinese medicine knowledge and Chinese medicine resource; Provide that a kind of side effect is little, good effect, cost is low, cure rate is high, the state of an illness repeatedly Chinese medicine not, thereby the treatment urinary system calculus is played good effect.
The specific embodiment
Motherland's medical science is discussed quite detailed to urinary system calculus disease, belong to " stranguria " category.The record of " stranguria caused by urinary stone " is just arranged in " General Treatise on the Cause and Symptoms of Diseases ", and accumulated abundant treatment experience.The origin cause of formation of stranguria caused by urinary stone is the same with other gonorrheas, is damp and hot holding in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels mostly, and a little less than the deficiency of kidney-QI, functioning of bladder is unfavorable, and damp and hot interior giving birth to decocts water liquid impurity and form calculus." Huatuo's Zhongzang classic " institute cloud: " void is hindered healthy energy, and pathogenic heat are gradually dark, and knot gathers into sand, decocting in water salt and for example, and fiery big flood is few, salt is Cheng Shi gradually ", suffering from a deficiency of the kidney is this, damp and hot QI and blood hands over resistance to be mark.
The etiology and pathogenesis of urinary system calculus carries in " General Treatise on the Cause and Symptoms of Diseases ": the influence of " Zhu Linzhe, so bladder heat is also by suffering from a deficiency of the kidney ", think that its etiology and pathogenesis mainly is the unable mistake of the functioning of bladder department that suffers from a deficiency of the kidney, and damp-heat accumulation decocts body fluid, and with the passing of time the moon tires out, and gathers to form stone." formulary of peaceful benevolent dispensary " pointed out: " deficiency of kidney-QI, bladder has heat, and water channel is obstructed, drenches drop and does not declare, and goes out less and number, and umbilicus abdomen shoot is held work sometimes, overstrain is promptly sent out, or dung such as fermented bean drink, just or go out sandstone "." Gu opinion doctor system " said: " heat is in bladder, and it is long-pending to decoct day, gently then coagulates like fat, very then becomes sandstone." " medical secrets of official " also have " the heat institute of suffering from a deficiency of the kidney takes advantage of, and heat then becomes to drench ", the saying of " the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, urine are decocted by it, accumulate over a long period, and impurity is become sandstone in the urine ".
In a word, lithogenous main cause is to suffer from a deficiency of the kidney, and qi depression to blood stasis is the condition that forms calculus; Damp-heat in the urinary bladder is a pathologic basis, so in treatment, will catch this principal contradiction of suffering from a deficiency of the kidney, is main with tonifying kidney and nourishing yin; The method that is aided with circulation of qi promoting removing blood stasis with potent drugs, eliminating damp-heat is to reach the purpose of fossil, calculus.
Based on this principle, the Chinese medicine preparation of treatment urinary system calculus of the present invention comprises Medulla Junci, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Radix Notoginseng, Radix Rubiae, Fructus Polygoni Orientalis, Fructus Malvae, Herba Plantaginis, Radix Stephaniae Tetrandrae, Radix Adenophorae, Fructus Lycii, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra, the Radix Pulsatillae and Folium Sennae.
Each component pharmacology is following in the side:
Medulla Junci: cold nature, sweet in the mouth, light is gone into the heart, lung, small intestinal, urinary bladder channel; Have relieving stranguria by diuresis, the effect of clearing heart fire cures mainly cards such as gonorrhea, edema, dysuria, the puckery pain of oliguria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, aphtha of the mouth and tongue, wound; " medicineization justice ": lampwick; Abnormal smells from the patient is all light, and the lighter's come-up is specially gone into cardiopulmonary; Nature and flavor are all light, the sharp key of light ability.Make top hot and suffocating descending, go out from urine.Cure mainly the cough pharyngalgia, the eye red blurred vision, the stranguria with urinary obstruction edema, dysuria, the summer-heat turbid urine, the nocturnal fretfulness in infants, all the merit of heat clearing away is also.Generation is doubted pastel thing, thinks that power is thin and ignore it, does not know expelling the excess with mild diaphoretic, and light master is in oozing, and only this can lead the heat of cardiopulmonary, go up certainly along following, and regulating fluid apssage, following defeated bladder, its power solely wins.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, return liver, gallbladder, lung meridian, the effect of expelling wind and removing dampness, dissipating blood stasis analgesic therapy, preventing phlegm from forming and stopping coughing is arranged, be used for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
Radix Platycodonis: bitter in the mouth, suffering, slightly warm in nature is gone into lung meridian, has the effect of expelling phlegm for arresting cough, lung qi dispersing evacuation of pus, cures mainly cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Radix Notoginseng: warm in nature, sweet in the mouth, little hardship are returned liver, stomach warp, have hemostasis, dissipating blood stasis, detumescence; The analgesic effect cures mainly: control haematemesis, and hemoptysis, epistaxis is had blood in stool; Dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia; Fall and pounce on blood stasis, traumatic hemorrhage, cards such as carbuncle pain, modern pharmacology prove, Radix Notoginseng can hemostasis, antithrombotic, promotion hemopoietic, antiinflammatory, protect the liver, antitumor, analgesia, cardiovascular is had good effect.
Radix Rubiae: cold in nature, bitter in the mouth is returned Liver Channel, effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling cures mainly: the heat in blood spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Amenorrhea; Postpartum stagnation stomachache; Traumatic injury; Rheumatic arthralgia; Jaundice; Carbuncle sore; Hemorrhoid are swollen, and Radix Rubiae has protective effect to acute myocardial ischemia, and Staphyloccocus aureus, streptococcus pneumoniae, hemophilus influenza are had inhibitory action.
Fructus Polygoni Orientalis: distinguish the flavor of, cold nature is gone into liver, stomach warp, has promoting flow of QI and blood, and the effect of hard masses softening and resolving is used for abdominal distention, hepatosplenomegaly, the tuberculosis of cervical lymph nodes, cards such as clearing away heat to improve acuity of vision.
Fructus Malvae: sweet in the mouth, puckery, cool in nature, return bladder, large intestine, small intestine meridian, have the effect of clearing away heat and promoting diuresis, stimulating milk secretion eliminating carbuncle, loosening bowel to relieve constipation, be used for stranguria, edema, dysuria, agalactia, cards such as acute mastitis.
Herba Plantaginis: sweet in the mouth, light, cold nature is returned lung meridian, Liver Channel, kidney channel, urinary bladder channel, has clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, makes eye bright, the expectorant effect, cures mainly main dysuria; The stranguria with turbid discharge leukorrhagia; The edema distension; The heat-damp in summer dysentery; Conjunctival congestion is hidden from view; The expectorant heat syndrome cough is breathed heavily, and Herba Plantaginis has diuresis, urinary calculus removing effect.
The Radix Pulsatillae: bitter in the mouth, cold in nature, go into stomach, large intestine channel, have heat-clearing and toxic substances removing, the effect of eliminating pathogenic heat from blood to cure dysentery, being mainly used in gastrointestinal has damp and hot stagnant heating stomachache, dysentery pus and blood, cards such as tenesmus; To the hematodiarrhoea hematochezia better effects if of large intestine heat in blood, dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus, Sha Shi door bacterium there is stronger inhibitory action.
Radix Stephaniae Tetrandrae: bitter in the mouth, suffering, cold in nature, go into bladder, kidney channel; Have inducing diuresis to remove edema, the function of wind-expelling pain-stopping is used for edema due to the retention of water-damp in the body; dysuria, and cards such as rheumatic arthralgia, Radix Stephaniae Tetrandrae can make myocardial contraction weaken; cardiac pump function each item index reduces, and coronary artery dilator is arranged, increase the effect of coronary flow.
Radix Adenophorae: sweet in the mouth, little hardship, cold nature is gone into lung, stomach warp; Nourishing the lung to arrest cough is arranged, and the effect of nourishing the stomach to promote the production of body fluid is mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, chronic cough expectorant blood; Cards such as deficiency of stomach-Yin, mouthfeel parched throat, constipation, the few tongue of red tongue; Can improve cellular immunization and non-specific immunity, suppress humoral immunization, have the function of regulating immunologic balance.
Fructus Lycii: sweet in the mouth, property are flat, go into liver, kidney channel, liver and kidney tonifying is arranged, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; Cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat, goes into liver, kidney channel.Radix Achyranthis Bidentatae is used for invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow; Ignite (blood) descending; Inducing diuresis for treating stranguria syndrome cures mainly soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Blood circulation promoting and blood stasis dispelling.
Radix Paeoniae Rubra: bitter in the mouth, little hardship, go into Liver Channel, removing fire from the liver is arranged, clearing away heat and cooling blood, the effect of stasis-dispelling and pain-killing is mainly used in the vigorous conjunctival congestion and swelling pain of liver-fire, has a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule is hemorrhage, and the blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Blood is capable to block caused various pain; The symptoms such as furuncle carbuncle of heat in blood poison Sheng.
Folium Sennae: sweet in the mouth, hardship, cold in nature, go into large intestine channel, purging heat to relax the bowels is arranged, the stagnate merit of diuretic of row is mainly used in the constipation of the stagnant the intestines and stomach of accumulation of heat, the abdominal distention abdominal distention of accumulation of food in the stomach and intes tine due to indigestion, symptoms such as anorexia.
Further preferred, the said Chinese medicine preparation that is used to treat urinary system calculus only is made up of said components.
The said Chinese medicine preparation that is used for treating urinary system calculus, the ratio of weight and number of various components can be preferably: 15～25 weight portion Medulla Juncies, 15～25 weight portion Rhizoma Polygoni Cuspidati, 5～10 weight portion Radix Platycodoniss, 20～30 weight portion Radix Notoginseng, 20～30 weight portion Radix Rubiaes, 20～30 weight parts water Fructus Carthami tinctoriis, 25～35 weight portion Fructus Malvae, 35～45 weight portion Herba Plantaginiss, 25～35 weight portion Radixs Stephaniae Tetrandrae, 50～70 weight portion Radix Adenophoraes, 65～80 weight portion Fructus Lycii, 20～30 weight portion Radix Achyranthis Bidentataes, 20～30 weight portion Radix Paeoniae Rubra, 15～25 weight portion Radix Pulsatillaes and 15～25 weight portion Folium Sennae.
The said Chinese medicine preparation that is used for treating urinary system calculus, the ratio of weight and number of various components also can further be preferably: 20～25 weight portion Medulla Juncies, 20～25 weight portion Rhizoma Polygoni Cuspidati, 8～10 weight portion Radix Platycodoniss, 25～30 weight portion Radix Notoginseng, 25～30 weight portion Radix Rubiaes, 25～30 weight parts water Fructus Carthami tinctoriis, 30～35 weight portion Fructus Malvae, 40～45 weight portion Herba Plantaginiss, 30～35 weight portion Radixs Stephaniae Tetrandrae, 60～70 weight portion Radix Adenophoraes, 75～80 weight portion Fructus Lycii, 25～30 weight portion Radix Achyranthis Bidentataes, 25～30 weight portion Radix Paeoniae Rubra, 20～25 weight portion Radix Pulsatillaes and 20～25 weight portion Folium Sennae.
The dosage form of the said Chinese medicine preparation that is used to treat urinary system calculus can for: granule, honey refining pill, drop pill, capsule, tablet, powder, decoct, syrup, administering mode is preferably oral.
The further preferred therapeutic renal calculus of said treatment urinary system calculus, ureteral calculus, vesical calculus.
When the dosage form of Chinese medicine preparation of the present invention was capsule, its preparation method may further comprise the steps:
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step went on foot the dry powder blend that obtains with the first step to the three, added excipient, disintegrating agent mixing, dry, pulverizing, added fluidizer; Or process particle drying, add lubricant; Or process micropill; In incapsulating at last, obtain capsule, said excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants; Described disintegrating agent is sodium carboxymethyl cellulose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Described fluidizer (lubricant) is that magnesium stearate, differential silica gel and other have the pharmaceutic adjuvant of fluidizer effect.Excipient, disintegrating agent, the weight content of fluidizer (lubricant) in medicine are:: 5～70%, 1～30%, 0.1～10%.
When the dosage form of Chinese medicine preparation of the present invention was syrup, its preparation method may further comprise the steps:
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step; Dry powder blend with the first step to the three steps acquisition; Add water dissolution, regulate pH value to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently with 40% sodium hydroxide solution with respect to 2～3 times of mixture qualities; Promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.
Embodiment 1 Chinese materia medica syrup 1 of the present invention
20g Medulla Junci, 30g Fructus Malvae, 40g Herba Plantaginis, 60g Radix Adenophorae, 75g Fructus Lycii and 25g Radix Achyranthis Bidentatae are mixed, add the 750g determining alcohol and be 75% ethanol, heating and refluxing extraction 3 times; Each reflux, extract, 2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.10 (60 ℃) under 60 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 25g Radix Notoginseng, 25g Radix Rubiae and 25g Fructus Polygoni Orientalis are mixed, be ground into powder, using the 300g determining alcohol is that 80% ethanol is as solvent; Flooded 36 hours, and adopted percolation, collect percolate with the speed of per minute 2ml percolation slowly; Be concentrated into the mastic of relative density 1.27 (60 ℃); Dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 20g Rhizoma Polygoni Cuspidati, 8g Radix Platycodonis, 30g Radix Stephaniae Tetrandrae, 25g Radix Paeoniae Rubra, the 20g Radix Pulsatillae and 20g Folium Sennae are mixed, add the 620g determining alcohol and be 85% alcohol reflux 3 times, each 3 hours; Filter; Filtrating merges, and reclaims ethanol, is concentrated into the mastic of relative density 1.22 (60 ℃); In 65 ℃ of reduced vacuum dryings, get dry powder; Dry powder blend with the front obtains adds the 900g water dissolution, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds correctives sucrose 200g, potassium sorbate preservative 2g mix homogeneously subsequently, promptly gets syrup 1.
Embodiment 2 Chinese materia medica syrups 2 of the present invention
25g Medulla Junci, 35g Fructus Malvae, 45g Herba Plantaginis, 70g Radix Adenophorae, 80g Fructus Lycii and 30g Radix Achyranthis Bidentatae are mixed, add the 850g determining alcohol and be 75% ethanol, heating and refluxing extraction 3 times; Each reflux, extract, 2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.10 (60 ℃) under 60 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 30g Radix Notoginseng, 30g Radix Rubiae and 30g Fructus Polygoni Orientalis are mixed, be ground into powder, using the 360g determining alcohol is that 80% ethanol is as solvent; Flooded 36 hours, and adopted percolation, collect percolate with the speed of per minute 2ml percolation slowly; Be concentrated into the mastic of relative density 1.27 (60 ℃); Dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 25g Rhizoma Polygoni Cuspidati, 10g Radix Platycodonis, 35g Radix Stephaniae Tetrandrae, 30g Radix Paeoniae Rubra, the 25g Radix Pulsatillae and 25g Folium Sennae are mixed, add the 720g determining alcohol and be 85% alcohol reflux 3 times, each 3 hours; Filter; Filtrating merges, and reclaims ethanol, is concentrated into the mastic of relative density 1.22 (60 ℃); In 65 ℃ of reduced vacuum dryings, get dry powder; Dry powder blend with the front obtains adds the 1100g water dissolution, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds correctives sucrose 200g, potassium sorbate preservative 2g mix homogeneously subsequently, promptly gets syrup 2.
Embodiment 3 Chinese medicinal capsule agent 1 of the present invention
20g Medulla Junci, 30g Fructus Malvae, 40g Herba Plantaginis, 60g Radix Adenophorae, 75g Fructus Lycii and 25g Radix Achyranthis Bidentatae are mixed, add the 750g determining alcohol and be 75% ethanol, heating and refluxing extraction 3 times; Each reflux, extract, 2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.10 (60 ℃) under 60 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 25g Radix Notoginseng, 25g Radix Rubiae and 25g Fructus Polygoni Orientalis are mixed, be ground into powder, using the 300g determining alcohol is that 80% ethanol is as solvent; Flooded 36 hours, and adopted percolation, collect percolate with the speed of per minute 2ml percolation slowly; Be concentrated into the mastic of relative density 1.27 (60 ℃); Dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 20g Rhizoma Polygoni Cuspidati, 8g Radix Platycodonis, 30g Radix Stephaniae Tetrandrae, 25g Radix Paeoniae Rubra, the 20g Radix Pulsatillae and 20g Folium Sennae are mixed, add the 620g determining alcohol and be 85% alcohol reflux 3 times, each 3 hours; Filter; Filtrating merges, and reclaims ethanol, is concentrated into the mastic of relative density 1.22 (60 ℃); In 65 ℃ of reduced vacuum dryings, get dry powder; With the dry powder blend that the front obtains, add excipient starch 50g, disintegrating agent carboxymethyl base sodium cellulosate 8g mixing, dry, pulverizing, add fluidizer magnesium stearate 8g, in incapsulating, obtain capsule 1.
Embodiment 4 Chinese medicinal capsule agent 2 of the present invention
25g Medulla Junci, 35g Fructus Malvae, 45g Herba Plantaginis, 70g Radix Adenophorae, 80g Fructus Lycii and 30g Radix Achyranthis Bidentatae are mixed, add the 850g determining alcohol and be 75% ethanol, heating and refluxing extraction 3 times; Each reflux, extract, 2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.10 (60 ℃) under 60 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 30g Radix Notoginseng, 30g Radix Rubiae and 30g Fructus Polygoni Orientalis are mixed, be ground into powder, using the 360g determining alcohol is that 80% ethanol is as solvent; Flooded 36 hours, and adopted percolation, collect percolate with the speed of per minute 2ml percolation slowly; Be concentrated into the mastic of relative density 1.27 (60 ℃); Dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder; 25g Rhizoma Polygoni Cuspidati, 10g Radix Platycodonis, 35g Radix Stephaniae Tetrandrae, 30g Radix Paeoniae Rubra, the 25g Radix Pulsatillae and 25g Folium Sennae are mixed, add the 720g determining alcohol and be 85% alcohol reflux 3 times, each 3 hours; Filter; Filtrating merges, and reclaims ethanol, is concentrated into the mastic of relative density 1.22 (60 ℃); In 65 ℃ of reduced vacuum dryings, get dry powder; With the dry powder blend that the front obtains, add excipient starch 50g, disintegrating agent carboxymethyl base sodium cellulosate 8g mixing, dry, pulverizing, add fluidizer magnesium stearate 8g, in incapsulating, obtain capsule 2.
Embodiment 5 clinical experiments
Clinical data
The urinary system calculus patient that 2009～2010 years my sections accept for medical treatment; 139 examples, male 75 examples, women 64 examples, 12～74 years old age; The course of disease 1 thoughtful 25 years; The patient all has typical clinical symptoms and all is diagnosed as urinary system calculus through ultrasound diagnosis, wherein renal calculus 73 examples, ureter epimere calculus 29 examples, ureter hypomere calculus 20 examples, vesical calculus 17 examples, calculus transverse diameter 0.4cm * 0.4cm～1.6cm * 1.5cm.This group patient all in outpatient service and how tame hospitalize, all is unwilling to be treated surgically, and 139 routine patients are divided into treatment group and matched group (90 examples are organized in treatment, matched group 49 examples) at random, and two groups of ordinary circumstance no significant differences have comparability.
Criterion of therapeutical effect
Cure: clinical symptom disappearance, calculus is discharged, and B ultrasonic or CT check hydronephrosis disappear, and calculus sign disappears; Produce effects: clinical symptom disappearance, calculus is most of discharges, and B ultrasonic or CT check hydronephrosis alleviate, and calculus is dwindled; Take a turn for the better: the lumbago sx, calculus is partly discharged, and B ultrasonic or CT check hydronephrosis alleviate, and calculus is dwindled; Invalid: between the lumbago symptom or the time send out, B ultrasonic or CT check renal calculus does not have obviously and dwindles, or behind rubble, assembles again.
Therapeutic Method
With B ultrasonic diagnostic apparatus (the Italian hundred black and white diasonograph AU4 of victory company types) inspection calculus and location.Lithotrite adopts the Hui Kang-5 multi-functional lithotrite of type water-bag type extracorporeal shock wave (Sino-foreign joint venture, ShenZhen,GuangDong).Position: ventricumbent position.Running voltage: 10.9～11kv.Impact number of times: 2700 times.Time: 40～45min.Need rubble person once more, according to circumstances interval 15～20d.
Treatment group: with the Chinese materia medica syrup treatment of the embodiment of the invention 2.Each 100mL, every day 3 times, the 500mL that slowly drinks water again after taking medicine, 1 week was 1 course of treatment.
Matched group: the 4000mL that drinks water every day, 1 week was 1 course of treatment, a year the lighter can suitably do the motion (making human body stand on head) of driving in the wrong direction, in good time till.
The result
The treatment group: in medicine time in the shortest 1 week, calculus drains, the longest 28d, and average calculus drains time 8d; Matched group: calculus drains time in the shortest 3 weeks, maximum duration 145d, and average calculus drains time 47d.Two groups of curative effects are seen table 1.
Table 1 liang group curative effect situation comparison (example, n=139)
| Group | Cure | Produce effects | Take a turn for the better | Invalid | Total effective rate (%) |
| The treatment group | 72 | 17 | 1 | 0 | 100 |
| Matched group | 17 | 12 | 10 | 9 | 81.6 |
Model case 1
Open X, man, 48 years old.This trouble is gone to a doctor because of violent lumbago, through X line, ultrasound investigation, turns out to be right kidney, the multiple calculus of bladder, accompanies hematuria simultaneously.It is strong that patient's oliguria with reddish urine and pain, white and thin fur, arteries and veins sink string, with the Chinese medicine oral liquid treatment of the embodiment of the invention 1, each 100mL, every day 3 times.After being admitted to hospital four days, promptly discharge more brown fine sand, serve on 3 again, conscious improvement is as usual.After the X report from a liner is accused: kidney, ureter, bladder area are not seen calculus.Recovered and discharged is not seen recurrence so far.
Model case 2
Suddenly * *, man, 32 years old, first visit on July 15 in 2009.Patient right side lumbago, lower abdomen contracture 2 days, oliguria with yellow urine or hematuria, red tongue, yellow and thin fur, stringy and rolling pulse.Right percussion tenderness over kidney region is obvious.It is conventional to look into urine: RBC (+++).X line abdominal part is taken the photograph sheet: in the ureter, hypomere calculus shadow 112cm * 017cm.Diagnosis stranguria caused by urinary stone (qi stagnation and blood stasis type).With the Chinese medicine oral liquid treatment of the embodiment of the invention 1, each 100mL, takes and discharges 1 1.1cm * 0.7cm of calculus after 3 days at every day 3 times.Check X line is taken the photograph sheet calculus shadow and is disappeared.
Model case 3
Lee * *, man, 47 years old, first visit on August 8 in 2009.Private prosecution left lower quadrant paroxysmal pain half a year, symptoms such as outbreak companion frequent micturition, dysurea, right kidney district 0.8cm * 0.9cm calculus is pointed out in ultrasound diagnosis once.Surplus from clothes " uralyt " moon, calculus size, position no change are found in check.During first visit patient's symptom as above, red tongue, yellow and greasy fur, rolling pulse is with the treatment of the Chinese medicine oral liquid of the embodiment of the invention 2; Each 100mL, every day 3 times, take 6 days after, the patient is conscious urethral orifice severe pain when urine; And discharge grain of rice appearance sandstone number, and back check B ultrasonic, the report calculus disappears.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (8)
1. Chinese medicine composition that is used to treat urinary system calculus; It is characterized in that, comprising: Medulla Junci, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Radix Notoginseng, Radix Rubiae, Fructus Polygoni Orientalis, Fructus Malvae, Herba Plantaginis, Radix Stephaniae Tetrandrae, Radix Adenophorae, Fructus Lycii, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra, the Radix Pulsatillae and Folium Sennae.
2. Chinese medicine composition as claimed in claim 1; It is characterized in that: the weight fraction of each component ratio does in the said Chinese medicine composition, 15～25 weight portion Medulla Juncies, 15～25 weight portion Rhizoma Polygoni Cuspidati, 5～10 weight portion Radix Platycodoniss, 20～30 weight portion Radix Notoginseng, 20～30 weight portion Radix Rubiaes, 20～30 weight parts water Fructus Carthami tinctoriis, 25～35 weight portion Fructus Malvae, 35～45 weight portion Herba Plantaginiss, 25～35 weight portion Radixs Stephaniae Tetrandrae, 50～70 weight portion Radix Adenophoraes, 65～80 weight portion Fructus Lycii, 20～30 weight portion Radix Achyranthis Bidentataes, 20～30 weight portion Radix Paeoniae Rubra, 15～25 weight portion Radix Pulsatillaes and 15～25 weight portion Folium Sennae.
3. according to claim 1 or claim 2 Chinese medicine composition; It is characterized in that: the weight fraction of each component ratio does in the said Chinese medicine composition, 20～25 weight portion Medulla Juncies, 20～25 weight portion Rhizoma Polygoni Cuspidati, 8～10 weight portion Radix Platycodoniss, 25～30 weight portion Radix Notoginseng, 25～30 weight portion Radix Rubiaes, 25～30 weight parts water Fructus Carthami tinctoriis, 30～35 weight portion Fructus Malvae, 40～45 weight portion Herba Plantaginiss, 30～35 weight portion Radixs Stephaniae Tetrandrae, 60～70 weight portion Radix Adenophoraes, 75～80 weight portion Fructus Lycii, 25～30 weight portion Radix Achyranthis Bidentataes, 25～30 weight portion Radix Paeoniae Rubra, 20～25 weight portion Radix Pulsatillaes and 20～25 weight portion Folium Sennae.
4. like the described Chinese medicine composition of claim 1 to 3, it is characterized in that: the dosage form of said Chinese medicine composition can be granule, honey refining pill, drop pill, capsule, tablet, powder, decoct, syrup.
5. the capsule that adopts the described Chinese medicine composition of claim 1 to 4 to process is characterized in that: the method for preparing of said capsule comprises,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step went on foot the dry powder blend that obtains with the first step to the three, added excipient, disintegrating agent mixing, dry, pulverizing, added fluidizer; Or process particle drying, add lubricant; Or process micropill; In incapsulating at last, obtain capsule, said excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants; Described disintegrating agent is sodium carboxymethyl cellulose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Described fluidizer (lubricant) is that magnesium stearate, differential silica gel and other have the pharmaceutic adjuvant of fluidizer effect.Excipient, disintegrating agent, the weight content of fluidizer (lubricant) in medicine are:: 5～70%, 1～30%, 0.1～10%.
6. the syrup that adopts the described Chinese medicine composition of claim 1 to 4 to process is characterized in that: the method for preparing of said syrup comprises,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step; Dry powder blend with the first step to the three steps acquisition; Add water dissolution, regulate pH value to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently with 40% sodium hydroxide solution with respect to 2～3 times of mixture qualities; Promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
7. the method for preparing of the said Chinese medicine composition of claim 1 to 4 is characterized in that:
When the dosage form of said Chinese medicine composition was capsule, it comprised,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step went on foot the dry powder blend that obtains with the first step to the three, added excipient, disintegrating agent mixing, dry, pulverizing, added fluidizer; Or process particle drying, add lubricant; Or process micropill; In incapsulating at last, obtain capsule, said excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants; Described disintegrating agent is sodium carboxymethyl cellulose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Described fluidizer (lubricant) is that magnesium stearate, differential silica gel and other have the pharmaceutic adjuvant of fluidizer effect.Excipient, disintegrating agent, the weight content of fluidizer (lubricant) in medicine are:: 5～70%, 1～30%, 0.1～10%.
8. the method for preparing of the said Chinese medicine composition of claim 1 to 4 is characterized in that:
When the dosage form of said Chinese medicine composition was syrup, it comprised,
The first step by said mixed, adds determining alcohol with respect to 2～4 times in mixture and is 65%～75% ethanol with Medulla Junci, Fructus Malvae, Herba Plantaginis, Radix Adenophorae, Fructus Lycii and Radix Achyranthis Bidentatae; Heating and refluxing extraction 2～4 times; Each reflux, extract, 1 hour～2 hours, merge extractive liquid, is with the centrifugal remove impurity of tube centrifuge; Extracting solution after the remove impurity is evaporated to relative density of medicine liquid 1.05～1.10 (60 ℃) under 60 ℃～70 ℃ condition; Concentrated solution after concentrating is dry with spray dryer, be ground into 100～200 orders subsequently, obtain dry powder;
In second step,, be ground into powder with Radix Notoginseng, Radix Rubiae and Fructus Polygoni Orientalis proportional mixing; Use determining alcohol be 70%～80% ethanol as solvent, flood 24 hours～36 hours, the employing percolation is with the speed of per minute 1～2ml percolation slowly; Collect percolate, be concentrated into the mastic of relative density 1.25～1.27 (60 ℃), dry with spray dryer; Be ground into 100～200 orders subsequently, obtain dry powder, the alcoholic acid quality that is added is 3～5 times of the second step mixture quality;
The 3rd step, remaining component is mixed, adding with respect to 4 times～6 times amounts of mixture determining alcohol is 75%～85% alcohol reflux 2 times～4 times; Each 2 hours～3 hours, to filter, filtrating merges; Reclaim ethanol; Be concentrated into the mastic of relative density 1.20～1.22 (60 ℃),, get dry powder in 55 ℃～65 ℃ reduced vacuum dryings;
The 4th step; Dry powder blend with the first step to the three steps acquisition; Add water dissolution, regulate pH value to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently with 40% sodium hydroxide solution with respect to 2～3 times of mixture qualities; Promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
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| CN 201210059205 CN102552571B (en) | 2012-02-28 | 2012-02-28 | Traditional Chinese medicine composition for treating urinary calculus, capsule, syrup and preparation method |
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| CN 201210059205 Expired - Fee Related CN102552571B (en) | 2012-02-28 | 2012-02-28 | Traditional Chinese medicine composition for treating urinary calculus, capsule, syrup and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943559A (en) * | 2017-05-05 | 2017-07-14 | 青岛市黄岛区中医医院 | It is a kind of to treat Chinese medicine composition of stone in urinary system and preparation method thereof |
| CN111135234A (en) * | 2020-01-16 | 2020-05-12 | 刘侠 | Traditional Chinese medicine composition for treating calculus |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1139576A (en) * | 1996-03-13 | 1997-01-08 | 刘述昌 | Making method for Huashiwan, a medicinal pill for gall and kidney stone |
| CN1268372A (en) * | 1999-03-31 | 2000-10-04 | 谭丰良 | Medicine for curing lithangiuria |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1139576A (en) * | 1996-03-13 | 1997-01-08 | 刘述昌 | Making method for Huashiwan, a medicinal pill for gall and kidney stone |
| CN1268372A (en) * | 1999-03-31 | 2000-10-04 | 谭丰良 | Medicine for curing lithangiuria |
Non-Patent Citations (4)
| Title |
|---|
| 《中医药研究》 20001031 韦建进 中医药治疗泌尿系结石研究进展 59-60 1-8 第16卷, 第5期 * |
| 《河南中医药学刊》 19960430 张茂信等 加味石苇散治疗泌尿系结石34例 38-39 1-4 第11卷, 第2期 * |
| 张茂信等: "加味石苇散治疗泌尿系结石34例", 《河南中医药学刊》, vol. 11, no. 2, 30 April 1996 (1996-04-30), pages 38 - 39 * |
| 韦建进: "中医药治疗泌尿系结石研究进展", 《中医药研究》, vol. 16, no. 5, 31 October 2000 (2000-10-31), pages 59 - 60 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943559A (en) * | 2017-05-05 | 2017-07-14 | 青岛市黄岛区中医医院 | It is a kind of to treat Chinese medicine composition of stone in urinary system and preparation method thereof |
| CN111135234A (en) * | 2020-01-16 | 2020-05-12 | 刘侠 | Traditional Chinese medicine composition for treating calculus |
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| CN102552571B (en) | 2013-07-10 |
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