CN108771883A - A kind of traditional Chinese medicine extraction liquid film concentration and separation device - Google Patents

A kind of traditional Chinese medicine extraction liquid film concentration and separation device Download PDF

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Publication number
CN108771883A
CN108771883A CN201810602573.XA CN201810602573A CN108771883A CN 108771883 A CN108771883 A CN 108771883A CN 201810602573 A CN201810602573 A CN 201810602573A CN 108771883 A CN108771883 A CN 108771883A
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CN
China
Prior art keywords
tank
film
heating
chinese medicine
concentrated
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201810602573.XA
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Chinese (zh)
Inventor
储浩侠
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Hefei Feng Jie Biological Technology Co Ltd
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Hefei Feng Jie Biological Technology Co Ltd
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Priority to CN201810602573.XA priority Critical patent/CN108771883A/en
Publication of CN108771883A publication Critical patent/CN108771883A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/028Flow sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/028Flow sheets
    • B01D11/0284Multistage extraction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D36/00Filter circuits or combinations of filters with other separating devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D36/00Filter circuits or combinations of filters with other separating devices
    • B01D36/003Filters in combination with devices for the removal of liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

The invention discloses a kind of traditional Chinese medicine extraction liquid films to be concentrated and separated device, including agitator tank, heating tank, film concentration tank and cooling tank, the upper end of agitator tank is provided with motor, the lower end of motor is provided with blender and heated wall, connecting tube one and filter screen are provided between agitator tank and heating tank, the upper end of heating tank is provided with distillation collector and heating tube, the lower end side of heating tank and it is provided with inlet tube between film concentration tank upper end, heating tank is internally provided with the feedboard being connected with inlet tube and several atomizers, the lower end of high-pressure osmosis film one is provided with adsorption layer and high-pressure osmosis film two, the upper end side of film concentration tank is provided with compression pump and concentrated solution outlet, connecting tube two is provided between film concentration tank and cooling tank, the inner upper end of cooling tank is both provided with condenser pipe with lower end, the side of cooling tank is provided with return duct.Advantageous effect:Achieve the effect that film concentrates so that the extracting solution of Chinese medicine is more refined.

Description

A kind of traditional Chinese medicine extraction liquid film concentration and separation device
Technical field
The present invention relates to films to concentrate field, it particularly relates to which a kind of traditional Chinese medicine extraction liquid film is concentrated and separated device.
Background technology
Ingredient contained by Chinese medicine is sufficiently complex, existing containing plurality of active ingredients, and has invalid components, also include it is toxic at Point.It extracts its active ingredient and is further detached, purified, it is one in traditional Chinese medicine research field important to obtain effective monomer Content.Traditional Chinese medicine extraction is exactly to extract wherein active ingredient to greatest extent using some technologies so that the inherent quality of Chinese medicine preparation It is improved with clinical therapeutic efficacy, and then the effect of Chinese medicine is played to greatest extent.The extraction of Chinese medicine is Chinese Traditional Medicine Important unit operation, process, the selection of technological process and device configuration all by be directly related to Chinese medicine quality and Clinical effectiveness.The techniques such as traditional centrifugal process, plate-frame filtering method, fining agent method, alcohol deposition method, resin adsorption method can not carry Chinese medicine Liquid is taken to carry out effectively clarification and purification, while there is also such as filtration difficulties to block fast, resin plug-hole, alcohol precipitation solvent consumption Greatly, the problems such as causing environmental burden.
For the problems in the relevant technologies, currently no effective solution has been proposed.
Invention content
For the problems in the relevant technologies, the present invention proposes that a kind of traditional Chinese medicine extraction liquid film is concentrated and separated device, existing to overcome There is the above-mentioned technical problem present in the relevant technologies.
The technical proposal of the invention is realized in this way:
A kind of traditional Chinese medicine extraction liquid film concentration and separation device, including agitator tank, heating tank, film concentration tank and cooling tank, the stirring The upper end of tank is provided with motor, and the upper end side of the agitator tank is provided with feed inlet, and the lower end of the motor is provided through In agitator tank top middle portion described above and the blender inside the agitator tank is extended to, the inner wall of the agitator tank and separate One end of the blender is provided with heated wall, and connecting tube one, the company are provided between the agitator tank and the heating tank The middle part of take over one is provided with filter screen, the lower end of the filter screen and the water valve one being connected with the heating tank, described to add The upper end of hot tank is provided with distillation collector, and the lower end of the distillation collector is provided with heating tube, the lower end of the heating tank Side and inlet tube is provided between film concentration tank upper end, the heating tank is internally provided with and the inlet tube The lower end of the feedboard being connected, the feedboard is provided with several atomizers, and the lower end of the atomizer is provided with height Permeable membrane one, the lower end of the high-pressure osmosis film one is pressed to be provided with adsorption layer, the adsorption layer is far from the high-pressure osmosis film one Lower end be provided with high-pressure osmosis film two, the upper end side of the film concentration tank is provided with compression pump, the lower end of the compression pump It is provided with concentrated solution outlet, connecting tube two is provided between the film concentration tank and the cooling tank, the connecting tube two is close The lower end of the cooling tank is provided with sealing valve, and inner upper end and the lower end of the cooling tank are both provided with condenser pipe, described cold But tank is provided with return duct close to the side of the inlet tube and positioned at the side of the film concentration tank, and the cooling tank is far from institute The side for stating return duct is provided with water outlet.
Further, the inlet tube is provided with water pump one close to one end of the heating tank.
Further, the return duct is provided with water pump two close to one end of the cooling tank.
Further, the lower end of the compression pump is provided with the supporting rack being fixedly connected with the film concentration tank.
Further, the concentrated solution outlet is both provided with water valve two with the water outlet.
Further, the inlet tube and the return duct are close to the side of the film concentration tank and are provided with control valve.
Beneficial effects of the present invention are:Enter filter screen filtration in connecting tube one by liquid after stirring to enter in heating tank It is heated by heating tube, so that liquid molecule is active, the moisture content in drug is able to distillation removal, passes through the effect of compression pump Down so that liquid is concentrated by high-pressure osmosis film one and high-pressure osmosis film two, adsorption layer further adsorbs impurities in water, Jin Ertong Cross connecting tube two enter cooling tank in condenser pipe and return duct in by extracting solution, ceaselessly group branches away, multiple cycling extraction fills Code insurance barrier purification quality, to achieve the effect that film concentrates so that the extracting solution of Chinese medicine is more refined.
Description of the drawings
It in order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, below will be to institute in embodiment Attached drawing to be used is needed to be briefly described, it should be apparent that, the accompanying drawings in the following description is only some implementations of the present invention Example, for those of ordinary skill in the art, without creative efforts, can also obtain according to these attached drawings Obtain other attached drawings.
Fig. 1 is a kind of traditional Chinese medicine extraction liquid film concentration and separation apparatus structure schematic diagram according to the ... of the embodiment of the present invention.
In figure:
1, agitator tank;2, heating tank;3, film concentration tank;4, cooling tank;5, motor;6, feed inlet;7, blender;8, heated wall; 9, connecting tube one;10, filter screen;11, water valve one;12, collector is distilled;13, heating tube;14, inlet tube;15, feedboard; 16, atomizer;17, high-pressure osmosis film one;18, adsorption layer;19, high-pressure osmosis film two;20, compression pump;21, concentrate goes out Mouthful;22, connecting tube two;23, sealing valve;24, condenser pipe;25, return duct;26, water outlet;27, water pump one;28, water pump two; 29, supporting rack;30, water valve two;31, control valve.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained belong to what the present invention protected Range.
According to an embodiment of the invention, a kind of traditional Chinese medicine extraction liquid film concentration and separation device is provided.
As shown in Figure 1, traditional Chinese medicine extraction liquid film according to the ... of the embodiment of the present invention is concentrated and separated device, including agitator tank 1, heating The upper end of tank 2, film concentration tank 3 and cooling tank 4, the agitator tank 1 is provided with motor 5, the upper end side setting of the agitator tank 1 There are feed inlet 6, the lower end of the motor 5 to be provided through in 1 top middle portion of the agitator tank and extend in the agitator tank 1 The blender 7 in portion, the inner wall of the agitator tank 1 and one end far from the blender 7 are provided with heated wall 8, the agitator tank 1 Connecting tube 1 is provided between the heating tank 2, the middle part of the connecting tube 1 is provided with filter screen 10, the filter screen 10 lower end is equipped with the water valve 1 being connected with the heating tank 2, and the upper end of the heating tank 2 is provided with distillation collector 12, the lower end of the distillation collector 12 is provided with heating tube 13, the lower end side of the heating tank 2 and is concentrated positioned at the film Inlet tube 14 is provided between 3 upper end of tank, the heating tank 2 is internally provided with the feedboard being connected with the inlet tube 14 15, the lower end of the feedboard 15 is provided with several atomizers 16, and the lower end of the atomizer 16 is provided with high-pressure osmosis The lower end of film 1, the high-pressure osmosis film 1 is provided with adsorption layer 18, and the adsorption layer 18 is far from the high-pressure osmosis film One 17 lower end is provided with high-pressure osmosis film 2 19, and the upper end side of the film concentration tank 3 is provided with compression pump 20, the pressure The lower end of pump 20 is provided with concentrated solution outlet 21, and connecting tube 2 22 is provided between the film concentration tank 3 and the cooling tank 4, The connecting tube 2 22 is provided with sealing valve 23, the inner upper end of the cooling tank 4 and lower end close to the lower end of the cooling tank 4 It is both provided with condenser pipe 24, the cooling tank 4 is set close to the side of the inlet tube 14 and positioned at the side of the film concentration tank 3 It is equipped with return duct 25, side of the cooling tank 4 far from the return duct 25 is provided with water outlet 26.
By means of above-mentioned technical proposal, the filtering of filter screen 10 in connecting tube 1 is entered by liquid after stirring and enters heating It is heated by heating tube 13 in tank 2, so that liquid molecule is active, the moisture content in drug is able to distillation removal, passes through pressure So that liquid is concentrated by high-pressure osmosis film 1 and high-pressure osmosis film 2 19 under the action of pump 20, adsorption layer 18 further adsorbs Impurities in water, so by connecting tube 2 22 enter cooling tank 4 in condenser pipe 24 and return duct 25 in by extracting solution ceaselessly Group branches away, and multiple cycling extraction fully ensures purification quality, to achieve the effect that film concentrates so that the extracting solution of Chinese medicine is more Add refined.
In one embodiment, for above-mentioned water pump 1, the inlet tube 14 is close to one end of the heating tank 2 It is provided with water pump 1, so that the liquid in heating tank 2 is able to enter in film concentration tank 3 by inlet tube 14, Jin Erti High film concentration process processing efficiency.In addition, when concrete application, water pump 1 can regulate and control liquid flow velocity as needed.
In one embodiment, the return duct 25 is provided with water pump 2 28 close to one end of the cooling tank 4, to make It obtains the liquid in cooling tank 4 to be able to enter in film concentration tank 3 by return duct 25, so that film is dense again for condensed liquid It is reprocessed in contracting tank 3.In addition, when concrete application, water pump 2 28 can regulate and control liquid flow velocity as needed.
In one embodiment, for above-mentioned compression pump 20, the lower end of the compression pump 20 is provided with and the film The supporting rack 29 that concentration tank 3 is fixedly connected so that compression pump 20 and the fixation of film concentration tank 3 are more secured, and then improves pressure The stability of power pump 20 in use.In addition, when concrete application, the fixation of supporting rack 29 is welded, and reinforces stability.
In one embodiment, for above-mentioned water valve 2 30, the concentrated solution outlet 21 is equal with the water outlet 26 It is provided with water valve 2 30, so that concentrated solution outlet 21 and the liquid of water outlet 26 are controlled, and then improves film concentration The controlling of separator.In addition, when concrete application, water valve 2 30 is provided with handle, can open as needed.
In one embodiment, for above-mentioned control valve 31, the inlet tube 14 is close to the return duct 25 The side of the film concentration tank 3 is provided with control valve 31, so that inlet tube 14 and the liquid of return duct 25 are controlled, And then improve the controlling of film concentration and separation device.In addition, when concrete application, control valve 31 is according to water pump 1 and water pump 2 28 Demand switched.
Operation principle:In use, the Chinese medicine extracted is needed to be entered in agitator tank 1 by feed inlet 6, and then blender It is stirred under the driving of motor 5, while the heated wall 8 of 1 inside both sides of agitator tank accelerates the quick mixing of Chinese medicine, and then after stirring Liquid enters filter screen 10 in connecting tube 1 and is heated by heating tube 13 in filtering into heating tank 2, so that liquid molecule It is active, to which the atomizer 16 entered by inlet tube 14 in film concentration tank 3 sprays, and then make under the action of compression pump 20 Liquid is concentrated by high-pressure osmosis film 1 and high-pressure osmosis film 2 19, and adsorption layer 18 further adsorbs impurities in water, Jin Ertong Cross connecting tube 2 22 enter cooling tank 4 in condenser pipe 24 and return duct 25 in by extracting solution, ceaselessly group branches away, repeatedly follow Ring extraction fully ensures purification quality, is flowed out after the completion by water outlet, and then achievees the effect that film concentrates.
In conclusion by means of the above-mentioned technical proposal of the present invention, is entered in connecting tube 1 by liquid after stirring and filtered The filtering of net 10 enters in heating tank 2 is heated by heating tube 13, so that liquid molecule is active, the moisture content in drug is steamed It evaporates and removes, by making that liquid passes through high-pressure osmosis film 1 and high-pressure osmosis film 2 19 concentrates under the action of compression pump 20, inhale Attached layer 18 further adsorbs impurities in water, and then enters condenser pipe 24 and return duct 25 in cooling tank 4 by connecting tube 2 22 Middle by extracting solution, ceaselessly group branches away, and multiple cycling extraction fully ensures purification quality, to achieve the effect that film concentrates, makes The extracting solution for obtaining Chinese medicine is more refined.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.

Claims (6)

1. a kind of traditional Chinese medicine extraction liquid film is concentrated and separated device, which is characterized in that including agitator tank(1), heating tank(2), film concentration Tank(3)And cooling tank(4), the agitator tank(1)Upper end be provided with motor(5), the agitator tank(1)Upper end side setting There is feed inlet(6), the motor(5)Lower end be provided through in the agitator tank(1)Top middle portion simultaneously extends to described stir Mix tank(1)Internal blender(7), the agitator tank(1)Inner wall and far from the blender(7)One end be provided with heating Wall(8), the agitator tank(1)With the heating tank(2)Between be provided with connecting tube one(9), the connecting tube one(9)Middle part It is provided with filter screen(10), the filter screen(10)Lower end be equipped with and the heating tank(2)The water valve one being connected(11), institute State heating tank(2)Upper end be provided with distillation collector(12), the distillation collector(12)Lower end be provided with heating tube (13), the heating tank(2)Lower end side and be located at the film concentration tank(3)Inlet tube is provided between upper end(14), institute State heating tank(2)Be internally provided with and the inlet tube(14)The feedboard being connected(15), the feedboard(15)Under End is provided with several atomizers(16), the atomizer(16)Lower end be provided with high-pressure osmosis film one(17), the height Press permeable membrane one(17)Lower end be provided with adsorption layer(18), the adsorption layer(18)Far from the high-pressure osmosis film one(17)'s Lower end is provided with high-pressure osmosis film two(19), the film concentration tank(3)Upper end side be provided with compression pump(20), the pressure Pump(20)Lower end be provided with concentrated solution outlet(21), the film concentration tank(3)With the cooling tank(4)Between be provided with connection Pipe two(22), the connecting tube two(22)Close to the cooling tank(4)Lower end be provided with sealing valve(23), the cooling tank (4)Inner upper end and lower end be both provided with condenser pipe(24), the cooling tank(4)Close to the inlet tube(14)Side and Positioned at the film concentration tank(3)Side be provided with return duct(25), the cooling tank(4)Far from the return duct(25)One Side is provided with water outlet(26).
2. a kind of traditional Chinese medicine extraction liquid film according to claim 1 is concentrated and separated device, which is characterized in that the inlet tube (14)Close to the heating tank(2)One end be provided with water pump one(27).
3. a kind of traditional Chinese medicine extraction liquid film according to claim 1 is concentrated and separated device, which is characterized in that the return duct (25)Close to the cooling tank(4)One end be provided with water pump two(28).
4. a kind of traditional Chinese medicine extraction liquid film according to claim 1 is concentrated and separated device, which is characterized in that the compression pump (20)Lower end be provided with and the film concentration tank(3)The supporting rack being fixedly connected(29).
5. a kind of traditional Chinese medicine extraction liquid film according to claim 1 is concentrated and separated device, which is characterized in that the concentrate goes out Mouthful(21)With the water outlet(26)It is both provided with water valve two(30).
6. a kind of traditional Chinese medicine extraction liquid film according to claim 1 is concentrated and separated device, which is characterized in that the inlet tube (14)With the return duct(25)It is close to the film concentration tank(3)Side be provided with control valve(31).
CN201810602573.XA 2018-06-12 2018-06-12 A kind of traditional Chinese medicine extraction liquid film concentration and separation device Pending CN108771883A (en)

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CN201810602573.XA CN108771883A (en) 2018-06-12 2018-06-12 A kind of traditional Chinese medicine extraction liquid film concentration and separation device

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Application Number Priority Date Filing Date Title
CN201810602573.XA CN108771883A (en) 2018-06-12 2018-06-12 A kind of traditional Chinese medicine extraction liquid film concentration and separation device

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109550278A (en) * 2018-12-06 2019-04-02 禹州市天源生物科技有限公司 A kind of traditional Chinese medicine extraction enrichment facility
CN109998989A (en) * 2019-04-26 2019-07-12 安徽利民生物科技股份有限公司 A kind of folk prescription Ganoderma lucidum oral liquid production technology device
CN110812881A (en) * 2019-11-01 2020-02-21 恩施徕福硒业有限公司 Leaching equipment and process for leaching selenium flavone from rhizoma polygonati
CN112452157A (en) * 2020-11-26 2021-03-09 合肥市无穷术医疗器械有限责任公司 Collagen draws purification device

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Publication number Priority date Publication date Assignee Title
CN103041614A (en) * 2012-11-30 2013-04-17 广东医学院 Device and method for extracting and concentrating traditional Chinese medicine
CN103599244A (en) * 2013-11-21 2014-02-26 山东东阿阿胶股份有限公司 Blood replenishing and stomach nourishing compound donkey-hide gelatin syrup and preparation process thereof
CN105107226A (en) * 2015-08-10 2015-12-02 湖北民族学院 Medication separation and extraction apparatus
CN205199037U (en) * 2015-12-18 2016-05-04 南阳市环境保护局 Enrichment facility is drawed in circulation
CN205412322U (en) * 2016-03-30 2016-08-03 江西天施康中药股份有限公司 Traditional chinese medicine extraction and separation integration equipment
CN206081746U (en) * 2016-10-20 2017-04-12 广东真丽斯化妆品有限公司 Tea polyphenol high -purity extraction element for cosmetics
CN206837130U (en) * 2017-01-19 2018-01-05 江西桔王药业有限公司 A kind of Chinese medicine extract multiple-effect film concentrating and separating purification devices

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103041614A (en) * 2012-11-30 2013-04-17 广东医学院 Device and method for extracting and concentrating traditional Chinese medicine
CN103599244A (en) * 2013-11-21 2014-02-26 山东东阿阿胶股份有限公司 Blood replenishing and stomach nourishing compound donkey-hide gelatin syrup and preparation process thereof
CN105107226A (en) * 2015-08-10 2015-12-02 湖北民族学院 Medication separation and extraction apparatus
CN205199037U (en) * 2015-12-18 2016-05-04 南阳市环境保护局 Enrichment facility is drawed in circulation
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109550278A (en) * 2018-12-06 2019-04-02 禹州市天源生物科技有限公司 A kind of traditional Chinese medicine extraction enrichment facility
CN109998989A (en) * 2019-04-26 2019-07-12 安徽利民生物科技股份有限公司 A kind of folk prescription Ganoderma lucidum oral liquid production technology device
CN109998989B (en) * 2019-04-26 2021-02-05 安徽利民生物科技股份有限公司 Single-prescription ganoderma lucidum oral liquid production process device
CN110812881A (en) * 2019-11-01 2020-02-21 恩施徕福硒业有限公司 Leaching equipment and process for leaching selenium flavone from rhizoma polygonati
CN112452157A (en) * 2020-11-26 2021-03-09 合肥市无穷术医疗器械有限责任公司 Collagen draws purification device
CN112452157B (en) * 2020-11-26 2023-05-26 济南磐升生物技术有限公司 Collagen draws purification device

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Application publication date: 20181109