CN112452157A

CN112452157A - Collagen draws purification device

Info

Publication number: CN112452157A
Application number: CN202011342193.0A
Authority: CN
Inventors: 不公告发明人
Original assignee: Hefei Infinity Medical Instrument Co ltd
Current assignee: Jinan Pantheon Biotechnology Co ltd
Priority date: 2020-11-26
Filing date: 2020-11-26
Publication date: 2021-03-09
Anticipated expiration: 2040-11-26
Also published as: CN112452157B

Abstract

The invention relates to the technical field of collagen extraction, in particular to a collagen extraction and purification device, comprising a material tank, the upper end of the material tank is provided with a feeding pipe for supplying collagen raw materials, and the lower part of the material tank is integrally formed with a conical connection The main motor is fixed on the material tank by bolts, and the output end of the main motor drives a stirring paddle inserted into the material tank. The beneficial effects are as follows: the collagen purification device designed by the present invention can quickly pass through the first filter membrane, the second filter membrane and the third filter membrane to realize the purification of macromolecular components and small molecular impurities that do not meet the screening requirements in the collagen raw material. Effective filtration to achieve rapid purification, and the device can repeatedly use the internal solution to flush the collagen raw material, which not only saves resources, but also ensures the purity of the purification through repeated purification. At the same time, the device can be automated Therefore, it can effectively reduce labor costs.

Description

Collagen draws purification device

Technical Field

The invention relates to the technical field of collagen extraction, in particular to a collagen extraction and purification device.

Background

Collagen is an important component constituting an organism, and purified collagen can be used in the fields of medicines, cosmetics, foods, and the like. Collagen still has a large amount of impurity residues in the inside after raw materials are simply extracted, and partial collagen components with overlarge molecular weights are not suitable for subsequent processing and need to be cleaned in subsequent purification processes. However, the existing collagen purification equipment has incomplete functions, is difficult to effectively and completely remove inorganic salts and other components in the collagen raw material, and cannot well separate unqualified macromolecular components, so that the subsequent processing is not facilitated.

The novel collagen purification device capable of improving the impurity removal effect in the collagen can effectively solve the problems, and the collagen extraction and purification device is provided for the purpose.

Disclosure of Invention

The present invention aims to provide a collagen extraction and purification device to solve the problems of the background art.

In order to achieve the purpose, the invention provides the following technical scheme: a collagen extraction and purification device comprises a material tank, wherein the upper end of the material tank is provided with a feeding pipe for supplying a collagen raw material, a conical connecting pipe is integrally formed below the material tank, a main motor is fixedly installed on the material tank through a bolt, and the output end of the main motor drives a stirring paddle inserted into the material tank;

the bottom of the conical connecting pipe is fixedly provided with a flow guide pipe through a bolt, a first material valve, a second material valve and a third material valve are sequentially arranged on the flow guide pipe from top to bottom, the flow guide pipe is provided with a first collecting pipe between the first material valve and the second material valve, a second collecting pipe is arranged between the second material valve and the third material valve, the flow guide pipe is communicated with a second return pipe between the first material valve and the first collecting pipe, a first filtering membrane is fixedly arranged between the first collecting pipe and the second material valve through a bolt, and a third filtering membrane is fixedly arranged between the second collecting pipe and the third material valve through a bolt;

a first extrusion push rod is fixedly mounted on the first collecting pipe through a bolt, a first push plate inserted into the first collecting pipe is driven by the output end of the first extrusion push rod, a second extrusion push rod is fixedly mounted on the second collecting pipe through a bolt, a second push plate inserted into the second collecting pipe is driven by the output end of the second extrusion push rod, a first discharge pipe is communicated with the first collecting pipe, a first electromagnetic valve is fixedly mounted on the first discharge pipe, a second discharge pipe is communicated with the second collecting pipe, and a second electromagnetic valve is mounted on the second discharge pipe;

a separation tank is arranged on the side face of the material tank, a liquid storage tank is fixedly mounted at the upper end of the separation tank through a bolt, a second backflow pump communicated with the liquid storage tank is fixedly mounted at the bottom of the liquid storage tank through a bolt, the outlet end of the second backflow pump is communicated with the second backflow pipe, an extraction pump communicated with the inside of the separation tank is fixedly mounted on the separation tank through a bolt, and the inlet end of the extraction pump is communicated with the bottom of the flow guide pipe through an extraction pipe;

the upper end of the separation tank is fixedly provided with a main push rod through a bolt, the output end of the main push rod drives an extrusion plate inserted into the separation tank, the bottom of the separation tank is fixedly provided with a separation box through a bolt, a second filtering membrane is fixedly arranged in the separation box through a bolt, the separation box is fixedly provided with a first backflow pump communicated with the inside of the separation box through a bolt, and the output end of the first backflow pump is communicated with the liquid storage tank through a first backflow pipe;

the breather pipe that communicates with stripper plate top space is installed at the top of knockout drum, and the intercommunication has the supplementary feed liquor pipe of being connected with outside confession liquid equipment on the liquid storage pot, the bottom of knockout drum is provided with the fluid-discharge tube with the inside intercommunication of knockout drum, and installs the flowing back valve on the fluid-discharge tube, there is the controller through bolt fixed mounting on the material jar, and the controller pass through the wire respectively with second backflow pump, home push rod, flowing back valve, extraction pump, first extrusion push rod, third material valve, second solenoid valve, second material valve, first solenoid valve, first material valve, liquid feed pump, main motor, first backflow pump and second extrusion push rod electric connection.

Preferably, the side of stirring rake is through bolt fixed mounting be used for carrying out the side scraper blade of scraping to the collagen raw materials of adhesion on the material jar inner wall, and the bottom of stirring rake is through bolt fixed mounting be used for carrying out the bottom scraper blade of scraping to the collagen raw materials of adhesion on the taper joint pipe.

Preferably, the material tank is fixedly provided with a liquid supply pump communicated with the interior of the material tank through a bolt, the liquid inlet end of the liquid supply pump is connected with external liquid supply equipment through a liquid supply pipe, and the liquid supply pump is electrically connected with the controller through a cable.

Preferably, the first filtration membrane and the third filtration membrane are microfiltration membranes, and the second filtration membrane is a nanofiltration membrane.

Preferably, the controller is an S7-200 PLC device, and the main push rod, the first extrusion push rod and the second extrusion push rod are single-rod double-acting hydraulic rods.

Compared with the prior art, the invention has the beneficial effects that: the collagen purification device designed by the invention can rapidly and effectively filter macromolecular components and micromolecular impurities which do not meet the screening requirement in the collagen raw material through the first filtering membrane, the second filtering membrane and the third filtering membrane, so that rapid purification is realized, the device can repeatedly and circularly utilize the internal solution to wash the collagen raw material, resources are saved, the repeated purification can also ensure the purification purity, and meanwhile, the device can automatically perform purification operation, so that the labor cost can be effectively reduced, and the collagen purification device has high practical value.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a side view of the structure of the present invention;

FIG. 3 is a sectional view of the installation of the material tank and the draft tube of the present invention;

FIG. 4 is an assembled cross-sectional view of a fluid reservoir and a separation tank of the present invention.

In the figure: 1. a material tank; 2. a second reflux pump; 3. an auxiliary liquid inlet pipe; 4. a liquid storage tank; 5. a first return pipe; 6. a main push rod; 7. a breather pipe; 8. a separation tank; 9. a drain valve; 10. a liquid discharge pipe; 11. a pump; 12. a first extrusion push rod; 13. a first collection tube; 14. a second collection tube; 15. an extraction pipe; 16. a third material valve; 17. a second solenoid valve; 18. a second discharge pipe; 19. a second material valve; 20. a first solenoid valve; 21. a first discharge pipe; 22. a flow guide pipe; 23. a first material valve; 24. a tapered connecting pipe; 25. a liquid supply tube; 26. a liquid supply pump; 27. feeding pipes; 28. a main motor; 29. a controller; 30. a first backflow pump; 31. a separation tank; 32. a second filter membrane; 33. a second return pipe; 34. a pressing plate; 35. a first push plate; 36. a second push plate; 37. a first filter membrane; 38. a bottom scraper; 39. a side surface scraper; 40. a stirring paddle; 41. a second extrusion push rod; 42. a third filter membrane.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments obtained by those skilled in the art without creative efforts based on the technical solutions of the present invention belong to the protection scope of the present invention.

Referring to fig. 1 to 4, the present invention provides a technical solution: a collagen extraction and purification device comprises a material tank 1, wherein an upper end of the material tank 1 is provided with a feeding pipe 27 for supplying a collagen raw material, a conical connecting pipe 24 is integrally formed below the material tank 1, a main motor 28 is fixedly installed on the material tank 1 through a bolt, an output end of the main motor 28 drives a stirring paddle 40 inserted into the material tank 1, a side surface of the stirring paddle 40 is fixedly provided with a side surface scraping plate 39 for scraping the collagen raw material adhered to the inner wall of the material tank 1 through the bolt, the bottom of the stirring paddle 40 is fixedly provided with a bottom scraping plate 38 for scraping the collagen raw material adhered to the conical connecting pipe 24 through the bolt, the side surface scraping plate 39 is adhered to the inner wall of the material tank 1 for placing the collagen raw material, and the bottom scraping plate 38 is adhered to the conical connecting pipe 24 for facilitating the collagen raw material to be adhered to the conical connecting pipe 24 and facilitating the collagen raw material to enter a guide pipe 22 through the conical connecting pipe 24;

referring to fig. 1 and 3, a draft tube 22 is fixedly installed at the bottom of a conical connection tube 24 through bolts, a first material valve 23, a second material valve 19 and a third material valve 16 are sequentially installed on the draft tube 22 from top to bottom, the draft tube 22 is provided with a first collecting tube 13 between the first material valve 23 and the second material valve 19, the draft tube 22 is provided with a second collecting tube 14 between the second material valve 19 and the third material valve 16, the draft tube 22 is communicated with a second return tube 33 between the first material valve 23 and the first collecting tube 13, the draft tube 22 is fixedly provided with a first filtering membrane 37 between the first collecting tube 13 and the second material valve 19 through bolts, and a third filtering membrane 42 is fixedly installed between the second collecting tube 14 and the third material valve 16 through bolts;

a first extrusion push rod 12 is fixedly arranged on the first collecting pipe 13 through a bolt, a first push plate 35 inserted into the first collecting pipe 13 is driven by the output end of the first extrusion push rod 12, a second extrusion push rod 41 is fixedly arranged on the second collecting pipe 14 through a bolt, and the output end of the second extrusion push rod 41 drives a second push plate 36 inserted into the second collecting pipe 14, the first collecting pipe 13 is communicated with a first discharge pipe 21, a first electromagnetic valve 20 is fixedly arranged on the first discharge pipe 21, a second discharge pipe 18 is communicated with the second collecting pipe 14, the second electromagnetic valve 17 is arranged on the second discharge pipe 18, the rear end of the first push plate 35 is fixedly provided with a protective sleeve for preventing the collagen raw material from entering the rear end of the first push plate, and the rear end of the second push plate 36 is fixedly provided with a protective sleeve for preventing the collagen raw material from entering the rear end of the second push plate 36;

referring to fig. 1 and 4, a separation tank 8 is arranged on the side surface of a material tank 1, a liquid storage tank 4 is fixedly mounted at the upper end of the separation tank 8 through a bolt, a second backflow pump 2 communicated with the liquid storage tank 4 is fixedly mounted at the bottom of the liquid storage tank 4 through a bolt, the outlet end of the second backflow pump 2 is communicated with a second backflow pipe 33, an extraction pump 11 communicated with the inside of the separation tank 8 is fixedly mounted on the separation tank 8 through a bolt, and the inlet end of the extraction pump 11 is communicated with the bottom of a flow guide pipe 22 through an extraction pipe 15;

the upper end of the separation tank 8 is fixedly provided with a main push rod 6 through a bolt, the output end of the main push rod 6 drives an extrusion plate 34 inserted into the separation tank 8, the bottom of the separation tank 8 is fixedly provided with a separation box 31 through a bolt, a second filtering membrane 32 is fixedly arranged in the separation box 31 through a bolt, the separation box 31 is fixedly provided with a first backflow pump 30 communicated with the inside of the separation box 31 through a bolt, and the output end of the first backflow pump 30 is communicated with the liquid storage tank 4 through a first backflow pipe 5;

referring to fig. 1 to 4, a vent pipe 7 communicated with a space above an extrusion plate 34 is installed at the top of a separation tank 8, an auxiliary liquid inlet pipe 3 connected with external liquid supply equipment is communicated with a liquid storage tank 4, a liquid discharge pipe 10 communicated with the inside of the separation tank 8 is arranged at the bottom of the separation tank 8, a liquid discharge valve 9 is installed on the liquid discharge pipe 10, a controller 29 is fixedly installed on a material tank 1 through bolts, and the controller 29 is electrically connected with a second backflow pump 2, a main push rod 6, the liquid discharge valve 9, an extraction pump 11, a first extrusion push rod 12, a third material valve 16, a second electromagnetic valve 17, a second material valve 19, a first electromagnetic valve 20, a first material valve 23, a liquid supply pump 26, a main motor 28, a first backflow pump 30 and a second extrusion push rod 41 through wires;

the material tank 1 is fixedly provided with a liquid supply pump 26 communicated with the interior of the material tank 1 through bolts, the liquid inlet end of the liquid supply pump 26 is connected with an external liquid supply device through a liquid supply pipe 25, the liquid supply pump 26 is electrically connected with a controller 29 through a cable, the first filtering membrane 37 and the third filtering membrane are microfiltration membranes, the second filtering membrane 32 is a sodium filtering membrane, the controller 29 is an S7-200 type PLC device, and the main push rod 6, the first extrusion push rod 12 and the second extrusion push rod 41 are single-rod double-acting hydraulic rods.

The working principle is as follows: when the device is in use, firstly, the collagen raw material is sent into the material tank 1 by the feeding pipe 27, then the main motor 28 is utilized to drive the stirring paddle 40 to stir the collagen raw material, when the internal material is too dense, the corresponding solution can be sent into the material tank by the liquid supply pump 26 to be diluted, and after the collagen raw material is uniformly stirred, the purification process can be carried out. In the purification process, the first material valve 23 and the second material valve 19 are opened to enable the collagen raw material to enter the draft tube 22, when the draft tube 22 is filled, the first material valve 23 is closed and the third material valve 16 is opened, the extraction pump 11 is opened to start to send the solution in the draft tube 22 into the separation tank 8 through the extraction pipe 15, and the second backflow pump 2 also sends the purified solution in the liquid storage tank 4 into the first collection pipe 13 through the first extrusion push rod. The collagen raw material in the flow guiding pipe 22 will move downwards along the flowing direction of the solution, and then will be filtered by the first filtering membrane 37, so that the unqualified macromolecular substances which can not pass through the first filtering membrane 37 will stay in the first collecting pipe 13, while the qualified substance components will continue to move downwards and then be filtered by the third filtering membrane 42, so that the qualified collagen molecules will stay in the second collecting pipe 14, and then the other fine particulate substances in the solution will be carried by the solution and continue to be sent into the separating tank 8, these substances include various impurity components such as inorganic salts, etc., when the substance in the flow guiding pipe 22 is flushed by the purified solution provided by the second backflow pipe 33 for a specified time, it can be considered that all the qualified collagen has entered into the second collecting pipe 14, and all the small molecular impurities have been sent into the separating tank 8, then the second reflux pump 2 stops supplying liquid, the air pump 11 stops pumping, the second material valve 19 and the third material valve 16 start closing, the first electromagnetic valve 20 and the second electromagnetic valve 17 are opened, at this time, the first extrusion push rod 12 drives the first push plate 35 to extrude the material in the first collection pipe 13 so as to discharge the material through the first discharge pipe 21, the second extrusion push rod 41 drives the second push plate 36 to extrude the material in the second collection pipe 14 so as to discharge the material through the second discharge pipe 18, when the material in the first collection pipe 13 and the second collection pipe 14 is completely discharged, the first push plate 35 and the second push plate 36 return to the corresponding positions, then the first electromagnetic valve 20 and the second electromagnetic valve 17 are closed again, the first material valve 23 and the second material valve 19 are opened again, at this time, the collagen raw material in the material tank 1 can be filled in the guide pipe 22 again, when the draft tube 22 is filled, the first material valve 23 is closed again and the second backflow pump 2 and the extraction pump 11 are opened, so that continuous automatic feeding and purification operation is realized. The solution pumped into the separation tank 8 by the extraction pump is filtered by the second filtering membrane 32, so that the small molecular impurities in the solution are filtered and stay in the separation tank 8, the purified solution is pumped into the liquid storage tank 4 by the first backflow pump 30 to be used, the liquid storage tank 4 can also be filled with liquid required by the auxiliary liquid inlet pipe 3, when the solution pumped into the separation tank 8 by the extraction pump 11 fills the separation tank 8, the extraction pump 11 stops working, the main push rod 6 drives the extrusion plate 34 to downwards extrude the solution in the separation tank 8, so that the solution can be filtered by the second filtering membrane 32 at a higher flow rate, meanwhile, the solution below the extrusion plate 34 is continuously pumped by the first backflow pump 30, so that the small molecular impurities staying in the separation tank 8 are continuously concentrated, and when the extrusion plate 34 extrudes to a designated liquid level, the liquid discharge valve 9 can be opened, so that the concentrated small molecules and the residual solution are discharged out by the liquid discharge pipe 10 together with the concentrated small molecular impurities And then the drain valve 9 is closed, then the main push rod 6 drives the extrusion plate 34 to rise to the highest end, the extraction pump 11 continues to work and sends the liquid extracted from the second collecting pipe 14 into the space below the extrusion plate 34 in the rising process of the extrusion plate 34, and the vent pipe 7 arranged on the separation tank 8 can effectively facilitate the air exchange of the space above the extrusion plate 34 and avoid the situation that the extrusion plate 34 cannot be pressed down. The device can be quick through first filtration membrane 37, second filtration membrane 32 and third filtration membrane 42 realize carrying out effectual filtration to the macromolecular composition and the micromolecular impurity that are not conform to the screening requirement in the collagen raw materials, thereby realize quick purification, and the device can relapse cyclic utilization inside solution erode the collagen raw materials, not only save the resource, and the purity degree of purification can also be ensured to the purification of relapse, the device can be automatic simultaneously purify the operation, consequently, can effectual reduction labour cost, and has very high practical value.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a collagen draws purification device which characterized in that: the collagen production device comprises a material tank (1), wherein an upper end of the material tank (1) is provided with a feeding pipe (27) for supplying a collagen raw material, a conical connecting pipe (24) is integrally formed below the material tank (1), a main motor (28) is fixedly installed on the material tank (1) through a bolt, and an output end of the main motor (28) drives a stirring paddle (40) inserted into the material tank (1);

the bottom of the conical connecting pipe (24) is fixedly provided with a flow guide pipe (22) through a bolt, the flow guide pipe (22) is sequentially provided with a first material valve (23), a second material valve (19) and a third material valve (16) from top to bottom, the flow guide pipe (22) is provided with a first collecting pipe (13) between the corresponding first material valve (23) and the corresponding second material valve (19), the flow guide pipe (22) is provided with a second collecting pipe (14) between the corresponding second material valve (19) and the corresponding third material valve (16), the flow guide pipe (22) is communicated with a second return pipe (33) between the corresponding first material valve (23) and the corresponding first collecting pipe (13), the flow guide pipe (22) is fixedly provided with a first filtering membrane (37) at the middle position between the corresponding first collecting pipe (13) and the corresponding second material valve (19) through a bolt, and a third filtering membrane (42) is fixedly provided between the second collecting pipe (14) and the corresponding third material valve (16) through a bolt;

a first extrusion push rod (12) is fixedly mounted on the first collecting pipe (13) through a bolt, a first push plate (35) inserted into the first collecting pipe (13) is driven by the output end of the first extrusion push rod (12), a second extrusion push rod (41) is fixedly mounted on the second collecting pipe (14) through a bolt, a second push plate (36) inserted into the second collecting pipe (14) is driven by the output end of the second extrusion push rod (41), a first discharge pipe (21) is communicated with the first collecting pipe (13), a first electromagnetic valve (20) is fixedly mounted on the first discharge pipe (21), a second discharge pipe (18) is communicated with the second collecting pipe (14), and a second electromagnetic valve (17) is mounted on the second discharge pipe (18);

a separation tank (8) is arranged on the side face of the material tank (1), a liquid storage tank (4) is fixedly mounted at the upper end of the separation tank (8) through a bolt, a second backflow pump (2) communicated with the liquid storage tank (4) is fixedly mounted at the bottom of the liquid storage tank (4) through a bolt, the outlet end of the second backflow pump (2) is communicated with a second backflow pipe (33), an extraction pump (11) communicated with the inside of the separation tank (8) is fixedly mounted on the separation tank (8) through a bolt, and the inlet end of the extraction pump (11) is communicated with the bottom of the flow guide pipe (22) through an extraction pipe (15);

the upper end of the separation tank (8) is fixedly provided with a main push rod (6) through a bolt, the output end of the main push rod (6) drives an extrusion plate (34) inserted into the separation tank (8), the bottom of the separation tank (8) is fixedly provided with a separation box (31) through a bolt, a second filtering membrane (32) is fixedly arranged in the separation box (31) through a bolt, a first backflow pump (30) communicated with the inside of the separation box (31) is fixedly arranged on the separation box (31) through a bolt, and the output end of the first backflow pump (30) is communicated with the liquid storage tank (4) through a first backflow pipe (5);

the top of the separation tank (8) is provided with a vent pipe (7) communicated with the space above the extrusion plate (34), and the liquid storage tank (4) is communicated with an auxiliary liquid inlet pipe (3) connected with external liquid supply equipment, a liquid discharge pipe (10) communicated with the inside of the separation tank (8) is arranged at the bottom of the separation tank (8), a liquid discharge valve (9) is arranged on the liquid discharge pipe (10), a controller (29) is fixedly arranged on the material tank (1) through a bolt, and the controller (29) is respectively electrically connected with the second backflow pump (2), the main push rod (6), the liquid discharge valve (9), the extraction pump (11), the first extrusion push rod (12), the third material valve (16), the second electromagnetic valve (17), the second material valve (19), the first electromagnetic valve (20), the first material valve (23), the liquid supply pump (26), the main motor (28), the first backflow pump (30) and the second extrusion push rod (41) through leads.

2. The collagen extracting and purifying device according to claim 1, wherein: the side of stirring rake (40) has side scraper blade (39) that are used for carrying out the scraping to the collagen raw materials of adhesion on material jar (1) inner wall through bolt fixed mounting, and the bottom of stirring rake (40) has bottom scraper blade (38) that are used for carrying out the scraping to the collagen raw materials of adhesion on taper joint pipe (24) through bolt fixed mounting.

3. The collagen extracting and purifying device according to claim 1, wherein: the material tank (1) is fixedly provided with a liquid supply pump (26) communicated with the interior of the material tank (1) through bolts, the liquid inlet end of the liquid supply pump (26) is connected with external liquid supply equipment through a liquid supply pipe (25), and the liquid supply pump (26) is electrically connected with the controller (29) through a cable.

4. The collagen extracting and purifying device according to claim 1, wherein: the first filtration membrane (37) and the third filtration membrane (42) are microfiltration membranes, and the second filtration membrane (32) is a nanofiltration membrane.

5. The collagen extracting and purifying device according to claim 1, wherein: the controller (29) is an S7-200 type PLC device, and the main push rod (6), the first extrusion push rod (12) and the second extrusion push rod (41) are all single-rod double-acting hydraulic rods.