CN108771713A - A kind of decompression fat reducing composition and preparation method thereof - Google Patents
A kind of decompression fat reducing composition and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of decompression fat reducing composition and preparation method thereof, the raw material group of the Chinese medicine composition becomes：White-backed pseudo-ginseng total flavonoid, propolis flavone, hawthorn fruit total flavone extract, mulberry leaf, matrimony vine, Radix Glycyrrhizae.The chromocor extract extracted by using Radix et Rhizoma Gynurae divaricatae, propolis and hawthorn is as major function raw material, under interaction, not only plays the role of expanding blood vessel and lasting buck, moreover it is possible to significantly reduce serum cholesterol and triglycerides, achieve the effect that be depressured fat reducing.
Description
Technical field
The present invention relates to a kind of technical field of traditional Chinese medicines, more particularly, to a kind of decompression fat reducing composition and preparation method thereof.
Background technology
To becoming better and better, the salt standard of receiving of higher and higher degree development, crowd also constantly increases crowd's standard of living therewith
Add, along with manual labor is reduced, the chance of human locomotion is less, for a long time body's cholesterol metabolism disorder, and salt of receiving increases
Add, increases the burden of kidney, standard of living raising, weight gain.This is all an important factor for causing hypertension, so
The present middle-aged and the old, which has, much suffers from different degrees of hypertension, and hyperlipidemia makes high blood to improve people's health level
Pressure hyperlipidemia is improved, and occurs various drugs or food in the market.
Chinese patent《A kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat and preparation method thereof》(number of patent application：
CN201710528063.8) disclose a kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat and preparation method thereof, by hawthorn, Poria cocos,
Dried orange peel, radix bupleuri, grass-leaved sweetflag, rhizoma alismatis, the tuber of pinellia, the dried immature fruit of citron orange, Radix Glycyrrhizae composition；With abundant raw material, drug safety, it is quick, without pair make
The advantages of using.But its formula is directly prepared using various traditional Chinese medicine dryings, and active ingredient therein is made not obtain fully
It utilizes, therapeutic effect unobvious.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of decompression fat reducing composition and preparation method thereof, by using
The chromocor extract that Radix et Rhizoma Gynurae divaricatae, propolis and hawthorn extract not only has expansion as major function raw material under interaction
Open the effect of blood vessel and lasting buck, moreover it is possible to significantly reduce serum cholesterol and triglycerides, achieve the effect that be depressured fat reducing.
The present invention can be achieved through the following technical solutions：
A kind of decompression fat reducing composition, is made of the raw material of following parts by weight：10~20 parts of white-backed pseudo-ginseng total flavonoid,
10~16 parts of propolis flavone, 13~17 parts of hawthorn fruit total flavone extract, 25~30 parts of mulberry leaf, 6~10 parts of matrimony vine, Radix Glycyrrhizae 15~
20 parts.
Preferably, a kind of decompression fat reducing composition, is made of the raw material of following parts by weight：White-backed pseudo-ginseng total flavonoid 12
~18 parts, it is 12~14 parts of propolis flavone, 14~16 parts of hawthorn fruit total flavone extract, 26~28 parts of mulberry leaf, 7~9 parts of matrimony vine, sweet
16~18 parts of grass.
Preferably, a kind of decompression fat reducing composition, is made of the raw material of following parts by weight：White-backed pseudo-ginseng total flavonoid 15
Part, 13 parts of propolis flavone, 15 parts of hawthorn fruit total flavone extract, 27 parts of mulberry leaf, 8 parts of matrimony vine, 17 parts of Radix Glycyrrhizae.
Preferably, the preparation method of the propolis flavone is：It takes propolis to freeze 1~5h at -40 DEG C~-80 DEG C, crushes
At fine powder；The ethanol solution that the concentration of volume percent of 30~80 times of amounts are 60~80% is added in propolis after crushing, with super
High pressure extraction equipment extracts, and extraction pressure is 300~600Mpa, and the time of extraction is 5~15min；Take extracting solution dense
Contracting, it is dry, obtain propolis flavone.
Preferably, the preparation method of the hawthorn fruit total flavone extract is：Hawthorn is removed the peel into decladding, takes pulp, is added 10
60% alcohol reflux of amount extracts 2 times again, extracts 1.5h every time, merges extracting solution, recycles ethyl alcohol, obtains medicinal extract, 5 times of medicinal extract addition
Distilled water is measured, stands overnight, supernatant is collected by centrifugation, with ammonium hydroxide tune pH to 7~8, is added in large pore resin absorption column, adjusts
Flow velocity 5mL/min washes away impurity with distilled water, using ethyl alcohol as mobile phase desorption, recycles ethyl alcohol, obtains hawthorn fruit total flavone extraction
Object.
Preferably, a kind of preparation method of decompression fat reducing composition, includes the following steps：
(1) it takes Radix et Rhizoma Gynurae divaricatae drying, crush, cross 12 mesh sieve, be added 40 times and measure the ethanol solution that mass fractions are 60%,
30min is impregnated at room temperature；Then the ultrasonic extraction 15min at 60 DEG C, filtering repeat to extract 3 times, merging filtrate to the dregs of a decoction,
It is spare to obtain white-backed pseudo-ginseng total flavonoid；
(2) mulberry leaf, matrimony vine and Radix Glycyrrhizae are cleaned respectively, its 10-20 times distilled water immersion measured extraction 30min is added, obtains
Chinese medicine extract；
(3) Chinese medicine extract obtained by step (2) is heated to 50 DEG C, and it is always yellow to be slowly added to Radix et Rhizoma Gynurae divaricatae while stirring
Ketone, propolis flavone and hawthorn fruit total flavone extract are to stirring to get the Chinese medicine composition for preparing of the present invention.
Each main functional component mechanism of action of the present invention is as follows：
Natural constituent there are many containing in Radix et Rhizoma Gynurae divaricatae, including polysaccharide, flavonoids, terpene, alkaloid, human body must
The 9 kinds of amino acid and 11 kinds of mineral elements needed；With anti-aging, antithrombotic and antitumaous effect, also have hypoglycemic, blood pressure lowering,
The functions such as reducing blood lipid and improvement gastrointestinal tract, can treat and prevent many diseases.
Its is mild-natured for honey, and bitter, pungent, micro-sweet have the function of bidirectional modulation blood pressure, and when blood pressure is higher, honey can promote
Make coronary vasodilation, blood pressure is made to decline, when blood pressure declines to a certain extent, the acetylcholine in honey can help patient
The transport and utilization of internal cholesterol, can be such that blood pressure increases in turn, and in addition to this, honey has facilitation effect to brain function, production
It is raw that blood pressure is made to maintain normal self-discipline corrective action, therefore honey can be used for preventing artery sclerosis and coronary heart disease；Contain in propolis
Some flavone compound Quercetins can reduce the harm of lipid peroxidation confrontation blood vessel, prevent vascular sclerosis, and can also have
Effect ground reduces content of triglyceride, reduces platelet aggregation, improves microcirculation, alleviates excessively high blood pressure.
General flavone in hawthorn plays the role of expanding blood vessel and lasting buck, in addition, hawthorn also can significantly reduce serum courage
Sterol and triglycerides, effectively prevent atherosclerosis；It can be by enhancing myocardial contractive power, increasing cardiac output, expansion hat
Shape arteries, increase coronary blood flow, reduction myocardial oxygen consumption etc. play the role of cardiac stimulant and prevent anginal.
The present invention has following advantageous effect：
The chromocor extract that Chinese medicine composition prepared by the present invention has used Radix et Rhizoma Gynurae divaricatae, propolis and hawthorn to extract is made
For major function raw material, raw material is green safe, has no toxic side effect, by under interaction, not only having expansion blood vessel and persistently drop
The effect of pressure, moreover it is possible to significantly reduce serum cholesterol and triglycerides, achieve the effect that be depressured fat reducing.
Specific implementation mode
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, below
In conjunction with specific embodiments, the present invention is further explained.
Embodiment 1
A kind of decompression fat reducing composition, is made of the raw material of following parts by weight：10 parts of white-backed pseudo-ginseng total flavonoid, propolis
10 parts of flavones, 13 parts of hawthorn fruit total flavone extract, 25 parts of mulberry leaf, 6 parts of matrimony vine, 15 parts of Radix Glycyrrhizae.
The preparation method of the propolis flavone is：It takes propolis to freeze 1~5h at -40 DEG C~-80 DEG C, is ground into fine powder；
The ethanol solution that the concentration of volume percent of 30~80 times of amounts is 60~80% is added in propolis after crushing, uses ultra high pressure extraction
Equipment extracts, and extraction pressure is 300~600Mpa, and the time of extraction is 5~15min；Extracting solution is taken to concentrate, it is dry, it obtains
Propolis flavone.
The preparation method of the hawthorn fruit total flavone extract is：Hawthorn is removed the peel into decladding, takes pulp, 10 times of amounts are added
60% alcohol reflux extracts 2 times, extracts 1.5h every time, merges extracting solution, recycles ethyl alcohol, obtains medicinal extract, and medicinal extract is added 5 times of amounts and steams
Distilled water is stood overnight, and supernatant is collected by centrifugation, and with ammonium hydroxide tune pH to 7~8, is added in large pore resin absorption column, is adjusted flow velocity
5mL/min washes away impurity with distilled water, using ethyl alcohol as mobile phase desorption, recycles ethyl alcohol, obtains hawthorn fruit total flavone extract.
A kind of preparation method of decompression fat reducing composition, include the following steps：
(1) it takes Radix et Rhizoma Gynurae divaricatae drying, crush, cross 12 mesh sieve, be added 40 times and measure the ethanol solution that mass fractions are 60%,
30min is impregnated at room temperature；Then the ultrasonic extraction 15min at 60 DEG C, filtering repeat to extract 3 times, merging filtrate to the dregs of a decoction,
It is spare to obtain white-backed pseudo-ginseng total flavonoid；
(2) mulberry leaf, matrimony vine and Radix Glycyrrhizae are cleaned respectively, the distilled water immersion extraction 30min of its 10~20 times amounts are added,
Obtain Chinese medicine extract；
(3) Chinese medicine extract obtained by step (2) is heated to 50 DEG C, and it is always yellow to be slowly added to Radix et Rhizoma Gynurae divaricatae while stirring
Ketone, propolis flavone and hawthorn fruit total flavone extract are to stirring to get the Chinese medicine composition for preparing of the present invention.
Embodiment 2
A kind of decompression fat reducing composition, is made of the raw material of following parts by weight：12 parts of white-backed pseudo-ginseng total flavonoid, propolis
12 parts of flavones, 14 parts of hawthorn fruit total flavone extract, 26 parts of mulberry leaf, 7 parts of matrimony vine, 16 parts of Radix Glycyrrhizae.
Embodiment 3
A kind of decompression fat reducing composition, is made of the raw material of following parts by weight：15 parts of white-backed pseudo-ginseng total flavonoid, propolis
13 parts of flavones, 15 parts of hawthorn fruit total flavone extract, 27 parts of mulberry leaf, 8 parts of matrimony vine, 17 parts of Radix Glycyrrhizae.
Embodiment 4
A kind of decompression fat reducing composition, is made of the raw material of following parts by weight：18 parts of white-backed pseudo-ginseng total flavonoid, propolis
14 parts of flavones, 16 parts of hawthorn fruit total flavone extract, 28 parts of mulberry leaf, 9 parts of matrimony vine, 18 parts of Radix Glycyrrhizae.
Embodiment 5
A kind of decompression fat reducing composition, is made of the raw material of following parts by weight：20 parts of white-backed pseudo-ginseng total flavonoid, propolis
16 parts of flavones, 17 parts of hawthorn fruit total flavone extract, 30 parts of mulberry leaf, 10 parts of matrimony vine, 20 parts of Radix Glycyrrhizae.
Comparative example 1
Difference lies in without addition white-backed pseudo-ginseng total flavonoid in the composition of preparation with embodiment 1.
Comparative example 2
Difference lies in without addition propolis flavone in the composition of preparation with embodiment 1.
Comparative example 3
Difference lies in without addition hawthorn fruit total flavone extract in the composition of preparation with embodiment 1.
Efficacy validation
Test example 1
80 hypertension of selection are tested with the rat model of hyperlipidemia simultaneously, are randomly divided into 8 groups, every group 10,
Chinese medicine composition prepared by 1-5 of the embodiment of the present invention and comparative example 1-3 is fed respectively, is fed 10mg/kg daily, is continuously fed
One week, the rat average content with blood pressure internal after administration, total cholesterol and triglycerides before administration is measured, as a result such as
Shown in the following table 1：
The average content of the blood pressure of front and back rat, total cholesterol and triglycerides is administered in table 1
As seen from the above table, the reduction amount of embodiment group rat pressure value upon administration, total cholesterol and triglycerides is bright
It is aobvious to be better than comparative example group, illustrate that Chinese medicine composition prepared by the embodiment of the present invention has significant decompression fat reducing effect.
Test example 2
240 patients with hypertension and hyperlipidemia of selection test, and are randomly divided into 8 groups, and every group of 30 people distinguish
Chinese medicine composition prepared by 1-5 of the embodiment of the present invention and comparative example 1-3 is taken, twice daily, each 1g continuously takes one
The service condition of patient is observed after month.It is considered as recovery from illness by what the blood pressure of patient's body and blood fat restored normal value；By patient's body
Blood pressure and blood fat declined be considered as alleviation；It is considered as what the blood pressure of patient's body and blood fat did not improve in vain.Knot
Fruit is as shown in table 2 below：
The treatment of 2 each Chinese medicine composition of table
| Group | Recovery from illness/example | Alleviation/example | In vain/example | Efficient % |
| Embodiment 1 | 21 | 9 | 0 | 100 |
| Embodiment 2 | 23 | 7 | 0 | 100 |
| Embodiment 3 | 26 | 4 | 0 | 100 |
| Embodiment 4 | 24 | 6 | 0 | 100 |
| Embodiment 5 | 23 | 7 | 0 | 100 |
| Comparative example 1 | 12 | 10 | 8 | 73.3 |
| Comparative example 2 | 15 | 9 | 6 | 80.0 |
| Comparative example 3 | 16 | 8 | 6 | 80.0 |
As seen from the above table, by the comparison of embodiment 1 and comparative example 1 it is found that being added in the Chinese medicine composition of preparation white
Radix notoginseng flavones are carried on the back, the treated effect of patient can be improved 26.7%；By the comparison of embodiment 1 and comparative example 2 it is found that
Propolis flavone is added in the Chinese medicine composition of preparation, the treated effect of patient can be improved 20.0%；Pass through embodiment 1
With comparative example 3 comparison it is found that in the Chinese medicine composition of preparation add hawthorn fruit total flavone extract, by patient's or can provide
Material is efficient to improve 20.0%.
Specific example：
Lee 52 years old, suffers from hypertension, and Hyperlipidemia, inhibition of taking medicine has 3 years, when not taking medicine, blood pressure 92-
154mmHg, total cholesterol 230mg/dL.The Chinese medicine composition of the preparation of the embodiment of the present invention 2 is taken after 1 month, is continuously detected
Mean blood pressure is 71-135mmHg, and total cholesterol 190mg/dL is effectively relieved.
Marquis 45 years old, 85kg, suffers from hyperlipidemia more than 3 years, takes the present invention 1 month, and total cholesterol is by original
6.47mmol/L is down to 4.9mmol/L, and triglycerides is down to 0.97mmol/L, high density lipoprotein level by original 1.87mmol/L
White cholesterol, low density lipoprotein cholesterol are down in normal range (NR), and weight is down to 78kg, with obvious effects.
In summary, white-backed pseudo-ginseng total flavonoid, propolis flavone are added in Chinese medicine composition prepared by the embodiment of the present invention
With hawthorn fruit total flavone extract, the therapeutic effect of hypertension, hyperlipemia patient can be effectively improved, while three plays synergy
Effect.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the present invention's
Protection domain.
Claims (6)
1. a kind of decompression fat reducing composition, which is characterized in that be made of the raw material of following parts by weight：White-backed pseudo-ginseng total flavonoid 10
~20 parts, it is 10~16 parts of propolis flavone, 13~17 parts of hawthorn fruit total flavone extract, 25~30 parts of mulberry leaf, 6~10 parts of matrimony vine, sweet
15~20 parts of grass.
2. a kind of decompression fat reducing composition according to claim 1, which is characterized in that by the raw material group of following parts by weight
At：12~18 parts of white-backed pseudo-ginseng total flavonoid, 12~14 parts of propolis flavone, 14~16 parts of hawthorn fruit total flavone extract, mulberry leaf 26~
28 parts, 7~9 parts of matrimony vine, 16~18 parts of Radix Glycyrrhizae.
3. a kind of decompression fat reducing composition according to claim 2, which is characterized in that by the raw material group of following parts by weight
At：15 parts of white-backed pseudo-ginseng total flavonoid, 13 parts of propolis flavone, 15 parts of hawthorn fruit total flavone extract, 27 parts of mulberry leaf, 8 parts of matrimony vine, Radix Glycyrrhizae
17 parts.
4. according to a kind of decompression fat reducing composition of claims 1 to 3 any one of them, which is characterized in that the propolis flavone
Preparation method be：It takes propolis to freeze 1~5h at -40 DEG C~-80 DEG C, is ground into fine powder；Propolis after crushing is added 30
The ethanol solution that the concentration of volume percent of~80 times of amounts is 60~80%, is extracted with ultra high pressure extraction equipment, extraction pressure
Power is 300~600Mpa, and the time of extraction is 5~15min；Extracting solution is taken to concentrate, it is dry, obtain propolis flavone.
5. according to a kind of decompression fat reducing composition of claims 1 to 3 any one of them, which is characterized in that the hawthorn is always yellow
The preparation method of ketone extract is：Hawthorn is removed the peel into decladding, takes pulp, 10 times is added and measures 60% alcohol refluxs extraction 2 times, every time
1.5h is extracted, extracting solution is merged, recycles ethyl alcohol, obtains medicinal extract, medicinal extract is added 5 times of amount distilled water, stands overnight, supernatant is collected by centrifugation
Liquid is added with ammonium hydroxide tune pH to 7~8 in large pore resin absorption column, adjusts flow velocity 5mL/min, impurity is washed away with distilled water, with
Ethyl alcohol is mobile phase desorption, recycles ethyl alcohol, obtains hawthorn fruit total flavone extract.
6. a kind of prepare such as a kind of method of decompression fat reducing composition of Claims 1 to 5 any one of them, which is characterized in that
Include the following steps：
(1) it takes Radix et Rhizoma Gynurae divaricatae drying, crush, cross 12 mesh sieve, be added 40 times and measure the ethanol solution that mass fractions are 60%, in room temperature
Lower immersion 30min；Then the ultrasonic extraction 15min at 60 DEG C, filtering repeat extraction 3 times to the dregs of a decoction, and merging filtrate obtains the white back of the body
Radix notoginseng flavones are spare；
(2) mulberry leaf, matrimony vine and Radix Glycyrrhizae are cleaned respectively, the distilled water immersion extraction 30min of its 10~20 times amounts is added, obtains Chinese medicine
Extracting solution；
(3) Chinese medicine extract obtained by step (2) is heated to 50 DEG C, is slowly added to white-backed pseudo-ginseng total flavonoid, bee while stirring
Glue flavones and hawthorn fruit total flavone extract are to stirring the Chinese medicine composition prepared to get the present invention.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260201A (en) * | 1999-09-10 | 2000-07-19 | 张发平 | Chinese preparatory medicine and its preparation method |
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Application publication date: 20181109 |