CN108743904A - 一种治疗细菌性痢疾的药物及其制备方法 - Google Patents
一种治疗细菌性痢疾的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗细菌性痢疾的药物及其制备方法,其主要是由马齿苋、白头翁、白芍、仙鹤草、秦皮、槟榔、黄连、当归、山楂、人参、地榆、金银花、老鹳草、枳实、木槿花、马鞭草、败酱、苦参、墨旱莲按一定重量配比制备而成,本发明药物具有清热解毒、清热凉血、缓中止痛、大补元气、排脓破瘀的功能,用于治疗细菌性痢疾见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗细菌性痢疾的药物及其制备方法,属中药领域。
技术背景
细菌性痢疾是志贺菌属(痢疾杆菌)引起的肠道传染病,志贺菌经消化道感染人体后,引起结肠黏膜的炎症和溃疡,并释放毒素入血。中医则认为细菌性痢疾与湿热蕴结、疫毒壅盛、热毒内闭、气滞血瘀有关。由于西药治疗副作用大,因此人们对有效治疗细菌性痢疾的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗细菌性痢疾的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗细菌性痢疾的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明是选择马齿苋、白头翁、白芍、仙鹤草、秦皮、槟榔、黄连、当归、山楂、人参、地榆、金银花、老鹳草、枳实、木槿花、马鞭草、败酱、苦参、墨旱莲、干姜、地锦草、儿茶、大黄、白芷、乌梅、龙胆、吴茱萸、铁苋菜、木香药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗细菌性痢疾。其中选用马齿苋是因为其性味酸,寒,入大肠、肝、脾经,有清热解毒,散血消肿的功能,治热痢脓血,热淋,血淋,带下,痈肿恶疮,丹毒,瘰疬。选用白头翁是因为其性味苦,寒,入大肠、肝、胃经,有清热凉血,解毒的功能,治热毒血痢,温疟寒热,鼻衄,血痔。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用仙鹤草是因为其性味苦辛,平,入肺、肝、脾经,有止血,健胃的功能,治咯血,吐血,尿血,便血,赤白痢疾,崩漏带下,劳伤脱力,痈肿,跌打、创伤出血。选用秦皮是因为其性味苦,寒,入肝、胆经,有消热燥湿,平喘止咳,明目的功能,治细菌性痢疾,肠炎,白带,慢性气管炎,目赤肿痛,迎风流泪,牛皮癣。选用槟榔是因为其性味苦辛,温,入脾、胃、大肠经,有杀虫,破积,下气,行水的功能,治虫积、食滞,脘腹胀痛,泻痢后重,疟疾,水肿,脚气,痰癖,癥结。选用黄连是因为其性味苦,寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒,热盛心烦,痞满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿痛,火眼,口疮,痈疽疮毒,湿疹,汤火烫伤。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用人参是因为其性味甘微甘,温,入脾、肺经,有大补元气,固脱生津,安神的功能,治劳伤虚损,食少,倦怠,反胃吐食,大便滑泄,虚咳喘促,自汗暴脱,惊悸,健忘,眩晕头痛,阳萎,尿频,消渴,妇女崩漏,小儿慢惊及久虚不复,一切气血津液不足之症。选用地榆是因为其性味苦酸、寒。入肝、大肠经。凉血止血,清热解毒。治吐血,衄血,血痢,崩溃,肠风,痔漏,痈肿,湿疹,金疮,烧伤。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用老鹳草是因为其性味苦辛,有祛风,活血,清热解毒的功能,治风湿疼痛,拘挛麻木,痈疽,跌打,肠炎,痢疾。选用枳实是因为其性味苦,寒,入脾、胃经,有破气,散痞,泻痰,消积的功能,治胸腹胀痛,胸痹,痞痛,痰癖,水肿,食积,便秘,胃下垂,子宫下垂,脱肛。选用木槿花是因为其性味甘苦,凉,入脾、肺二经,有清热,利湿,凉血的功能,治肠风泻血,痢疾,白带。选用马鞭草是因为其性味苦,凉,入肝、脾经,有清热解毒,活血散瘀,利水消肿的功能,治外感发热,湿热黄疸,水肿,痢疾,疟疾,白喉,喉痹,淋病,经闭,癥瘕,痈肿疮毒牙疳。选用败酱是因为其性味苦,平,入肝、胃、大肠经,有清热解毒,排脓破瘀的功能,治肠痈,下痢,赤白带下,产后瘀滞腹痛,目赤肿痛,痈肿疥癣。选用苦参是因为其性味苦,寒,入肝、肾、大肠、小肠经,有清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿肺炎,疳积,急性扁桃体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用墨旱莲是因为其性味苦酸,凉,入肝、肾经,有凉血,止血,补肾,益阴的功能,治吐血,咳血,衄血,尿血,便血,血痢,刀伤出血,须发早白,白喉,淋浊,滞下,阴部湿痒。选用干姜是因为其性味辛,热,入脾、胃、肺经,有温中逐寒,回阳通脉的功能,治心腹冷痛,吐泻,肢冷脉微,寒饮喘咳,风寒湿痹,阳虚吐、衄、下血。选用地锦草是因为其性味辛,平,有清热解毒,活血,止血,利湿,通乳的功能,治菌痢,肠炎,咳血,吐血,便血,崩漏,外伤出血,湿热黄疸,乳汁不通,痈疽疔疮,跌打肿痛。选用儿茶是因为其性味苦、涩,微寒,归肺经,有收湿生肌敛疮的功能,治溃疡不敛,湿疹,口疮,跌扑伤痛,外伤出血。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用乌梅是因为其性味酸,温,入肝,脾,肺,大肠经,有收敛生津,安蛔驱虫的功能,治久咳,虚热烦渴,久疟,痢疾,便血,尿血,血崩,蛔厥腹痛,呕吐,钩虫病,牛皮癣,胬肉。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功能,治肝经热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴部湿痒。选用吴茱萸是因为其性味辛苦,温,有毒,入肝、胃经,有温中,止痛,理气,燥湿的功能,治呕逆吞酸,厥阴头痛,脏寒吐泻,脘腹胀痛,脚气,疝气,口疮溃疡,齿痛,湿疹,黄水疮。选用铁苋菜是因为其性味苦、涩、凉,归心、肺、经,有清热解毒,利湿,收敛止血。用于肠炎,痢疾,吐血、衄血、便血、尿血,崩漏;外治痈疖疮疡,皮炎湿疹。选用木香是因为其性味辛苦,温,入肺、肝、脾经,有行气止痛,温中和胃的功能,治中寒气滞,胸腹胀痛,呕吐,泄泻,下痢里急后重,寒疝。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效
马齿苋15-25克、白头翁10-15克、白芍10-20克、仙鹤草10-20克、秦皮10-15克、槟榔5-10克、黄连10-15克、当归10-20克、山楂15-20克、人参10-15克、地榆10-20克、金银花10-20克、老鹳草10-15克、枳实10-20克、木槿花5-15克、马鞭草5-15克、败酱10-15克、苦参5-15克、墨旱莲10-20克、干姜10-20克、地锦草10-15克、儿茶10-15克、大黄5-10克、白芷5-15克、乌梅10-15克、龙胆10-20克、吴茱萸3-9克、铁苋菜5-15克、木香10-15克。
优选为
马齿苋20克、白头翁12克、白芍15克、仙鹤草15克、秦皮12克、槟榔8克、黄连12克、当归15克、山楂18克、人参12克、地榆15克、金银花15克、老鹳草12克、枳实15克、木槿花10克、马鞭草10克、败酱12克、苦参10克、墨旱莲15克、干姜15克、地锦草12克、儿茶12克、大黄8克、白芷10克、乌梅12克、龙胆15克、吴茱萸6克、铁苋菜10克、木香12克。
本发明药物的制备方法如下
一、备料
1、马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
2、白头翁:拣净杂质,洗净,润透后切片,晒干;
3、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
4、仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
5、秦皮:拣去杂质,洗净,润透后切块或切段,晒干;
6、槟榔:拣去杂质,以清水浸泡,按气温情况换水,至泡透为止,捞起,切片,晾干;
7、黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
8、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
9、山楂:拣净杂质,筛去核;
10、人参:除去芦头,切段即可;
11、地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
12、金银花:筛去泥沙,拣净杂质;
13、老鹳草:拣去杂质,除去残根,用水洗净,捞出,切段,晒干;
14、枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
15、木槿花:拣净杂质,晒干;
16、马鞭草:拣净杂质,洗净,润软切段,晒干;
17、败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥;
18、苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
19、墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
20、干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
21、地锦草:夏、秋间采收,去根,晒干;
22、儿茶:除去杂质,用时捣碎;
23、大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
24、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
25、乌梅:拣净杂质,筛去灰屑,洗净,晒干;
26、龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
27、吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
28、铁苋菜:夏、秋季采割,除去杂质,晒干;
29、木香:将原生药放清水内洗净,捞出,闷润12—24小时使软,切片,晒干。
二、制备
1、将所述重量的马齿苋、白头翁、白芍、仙鹤草、秦皮、槟榔、黄连、当归、山楂、人参、地榆、金银花、老鹳草、枳实、木槿花、马鞭草、败酱、苦参、墨旱莲、干姜、地锦草、儿茶、大黄、白芷、乌梅、龙胆、吴茱萸、铁苋菜、木香放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中马齿苋清热解毒,散血消肿,白头翁有清热凉血,解毒的功能二者为君药;白芍养血柔肝,缓中止痛,敛阴收汗,仙鹤草有止血,健胃的功能,与秦皮、槟榔、黄连、当归、山楂为臣药,九味药共同发挥清热解毒、清热凉血、养血柔肝、缓中止痛、敛阴收汗、健胃的作用,治疗细菌性痢疾效力全面,且以清热解毒、清热凉血、缓中止痛为主,可治本;人参大补元气,固脱生津,安神的功能与地榆、金银花、老鹳草、枳实、木槿花、马鞭草为佐药;败酱有清热解毒,排脓破瘀的功能与余下诸药为使药,是治标。
本发明药物具有清热解毒、清热凉血、缓中止痛、大补元气、排脓破瘀的功能,用于治疗细菌性痢疾,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治细菌性痢疾门诊患者共52例。
2、诊断标准
典型症状为:发热、腹痛、腹泻、里急后重、黏液脓血便,同时伴有全身毒血症等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用1个疗程。
4、疗效评定标准
显效:细菌性痢疾症状消失,恢复正常,痊愈;
好转:患者发热、腹痛、腹泻、里急后重、黏液脓血便、全身毒血症的现象减轻,细菌性痢疾症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗细菌性痢疾患者52例,结果显效46例,显效率为88.46%,好转5例,好转率为9.61%,无效1例,总有效率为98.07%。
Claims (3)
1.一种治疗细菌性痢疾的药物,其特征在于:它是由下列重量范围内的原料药制成:
马齿苋15-25克、白头翁10-15克、白芍10-20克、仙鹤草10-20克、秦皮10-15克、槟榔5-10克、黄连10-15克、当归10-20克、山楂15-20克、人参10-15克、地榆10-20克、金银花10-20克、老鹳草10-15克、枳实10-20克、木槿花5-15克、马鞭草5-15克、败酱10-15克、苦参5-15克、墨旱莲10-20克、干姜10-20克、地锦草10-15克、儿茶10-15克、大黄5-10克、白芷5-15克、乌梅10-15克、龙胆10-20克、吴茱萸3-9克、铁苋菜5-15克、木香10-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
马齿苋20克、白头翁12克、白芍15克、仙鹤草15克、秦皮12克、槟榔8克、黄连12克、当归15克、山楂18克、人参12克、地榆15克、金银花15克、老鹳草12克、枳实15克、木槿花10克、马鞭草10克、败酱12克、苦参10克、墨旱莲15克、干姜15克、地锦草12克、儿茶12克、大黄8克、白芷10克、乌梅12克、龙胆15克、吴茱萸6克、铁苋菜10克、木香12克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
(2)白头翁:拣净杂质,洗净,润透后切片,晒干;
(3)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(4)仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
(5)秦皮:拣去杂质,洗净,润透后切块或切段,晒干;
(6)槟榔:拣去杂质,以清水浸泡,按气温情况换水,至泡透为止,捞起,切片,晾干;
(7)黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
(8)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(9)山楂:拣净杂质,筛去核;
(10)人参:除去芦头,切段即可;
(11)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
(12)金银花:筛去泥沙,拣净杂质;
(13)老鹳草:拣去杂质,除去残根,用水洗净,捞出,切段,晒干;
(14)枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
(15)木槿花:拣净杂质,晒干;
(16)马鞭草:拣净杂质,洗净,润软切段,晒干;
(17)败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥;
(18)苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
(19)墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
(20)干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
(21)地锦草:夏、秋间采收,去根,晒干;
(22)儿茶:除去杂质,用时捣碎;
(23)大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
(24)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
(25)乌梅:拣净杂质,筛去灰屑,洗净,晒干;
(26)龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
(27)吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
(28)铁苋菜:夏、秋季采割,除去杂质,晒干;
(29)木香:将原生药放清水内洗净,捞出,闷润12—24小时使软,切片,晒干;
(二)制备
(1)将所述重量的马齿苋、白头翁、白芍、仙鹤草、秦皮、槟榔、黄连、当归、山楂、人参、地榆、金银花、老鹳草、枳实、木槿花、马鞭草、败酱、苦参、墨旱莲、干姜、地锦草、儿茶、大黄、白芷、乌梅、龙胆、吴茱萸、铁苋菜、木香放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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