CN108743744A - A kind of bluish dogbane bee glue soft capsule and preparation method thereof - Google Patents
A kind of bluish dogbane bee glue soft capsule and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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Abstract
The present invention relates to medicines and health protection field, especially a kind of bluish dogbane bee glue soft capsule and preparation method thereof.This kind of bluish dogbane bee glue soft capsule, is mainly made of content and rubber, content is mainly prepared from the following raw materials in parts by weight：8-10 parts of 40-76 parts of apocynum extract, 50-85 parts of bee glue powder, 230-300 parts of grape seed oil and beeswax；Rubber is mainly prepared from the following raw materials in parts by weight：100-150 parts of gelatin, 40-60 parts of glycerine, 0.15-0.25 parts of Brown Ferric Oxide, temptation red 0.045-0.075 parts and appropriate purified water.A kind of bluish dogbane bee glue soft capsule and preparation method thereof of the present invention, compatibility advantages of simple make one internal high-density lipoprotein liver sterol using 3 kinds of apocynum extract, bee glue powder, grape seed oil raw materials combinations（HDL-C）It increases, low density lipoprotein cholesterol（LDL-C）It reduces, adjusts internal triglycerides（TG）Metabolism, reduce cholesterol level, fully and effectively prevent cardiovascular and cerebrovascular disease generation.
Description
Technical field
The present invention relates to medicines and health protection field, especially a kind of bluish dogbane bee glue soft capsule and preparation method thereof.
Background technology
In the past 30 years, the blood lipid level of Chinese population is stepped up, and dyslipidemia illness rate obviously increases.Chinese Adult blood
The extremely overall illness rate of fat is up to 40.4%.The raising of crowd's serum cholesterol level will lead to during~the year two thousand thirty in 2010 me
State's cardiovascular disease event about increases by 9,200,000.In recent years National survey the results show that hypercholesterolemia illness rate 4.9%；It is high
Triglycerides（TG）The illness rate 13.1% of mass formed by blood stasis；Low hdl cholesterol（HDL-C）The illness rate 33.9% of mass formed by blood stasis.I.e.
With low density lipoprotein cholesterol（LDL-C）Or the dyslipidemia with the characteristics of TC raisings is atherosclerotic cardiovascular disease
Disease（ASCVD）Important risk factor；It is horizontal to reduce LDL-C, morbidity and the death risk of ASCVD can be substantially reduced.I
The long-term queue Follow-up Data of state's population epidemiology shows that hypertension is significantly stronger than other painstaking effort to the pathogenic effects of population of China
Pipe disease risk factor.Clinic mostly uses Statins lipid-regulation medicine and cholesterol absorption inhibitor at present（Ezetimibe etc.）To reduce
LDL-C is horizontal, however cholesterol absorption inhibitor and statin combination can occur transaminase and increase and the side effects such as myalgia.
Therefore, LDL-C levels can be substantially reduced by how providing one kind, adjust TG contents, and soft capsule without side-effects,
It is those skilled in the art's urgent problem to be solved.
Invention content
The purpose of the present invention is to provide a kind of bluish dogbane bee glue soft capsules and preparation method thereof, overcome the aforementioned prior art
Deficiency, compatibility advantages of simple, can be substantially reduced LDL-C level, adjust internal triglycerides（TG）Metabolism, it is solid to reduce courage
Alcohol content, while lipid peroxidation substance is reduced, blood vessel elasticity is protected, is reduced blood pressure, while assisting reducing blood lipid, enhances heart and brain
The defencive function of blood vessel fully and effectively prevents the generation of cardiovascular and cerebrovascular disease, and without side-effects.
The technical scheme adopted by the invention to solve the technical problem is that：
A kind of bluish dogbane bee glue soft capsule, is mainly made of content and rubber, and the content is mainly by following parts by weight
Raw material be made：8-10 parts of 40-76 parts of apocynum extract, 50-85 parts of bee glue powder, 230-300 parts of grape seed oil and beeswax；Institute
Rubber is stated mainly to be prepared from the following raw materials in parts by weight：100-150 parts of gelatin, 40-60 parts of glycerine, Brown Ferric Oxide 0.15-
0.25 part, temptation red 0.045-0.075 parts and appropriate purified water.
Preferably, the content is mainly prepared from the following raw materials in parts by weight：56 parts of apocynum extract, bee glue powder
9 parts of 68 parts, 265 parts of grape seed oil and beeswax；The rubber is mainly prepared from the following raw materials in parts by weight：It is 125 parts of gelatin, sweet
50 parts of oil, 0.2 part of Brown Ferric Oxide, temptation red 0.06 part and appropriate purified water.
A kind of preparation method of bluish dogbane bee glue soft capsule, in turn includes the following steps：Prepare apocynum extract, propolis
Crushing, the modulation of color water, changes glue, pill, sizing, wipes ball, drying, selects pill package dispensing.
Preferably, the apocynum extract process for preparing includes following operation：Fresh Folium Apocyni Veneti is taken, cleans, dries in the air
It is dry, it is crushed to 10-20 mesh；75% ethyl alcohol extract 3 times, every time 2 when；200 mesh refined filtration of ethanol extract recycles ethyl alcohol, filtrate 70-
75 DEG C of vacuum-concentrcteds to proportion is 1.05-1.06 medicinal extract, is spray-dried, and is crushed, and 80 mesh sieve is crossed, and bluish dogbane extraction is made
Object.
Preferably, the propolis crushing process includes following operation：The accurate propolis weighed after -18 DEG C of freezings, opens powder
Broken machine, makes its 30-80s that dallies, confirms that machine is normal, and propolis, which is poured into pulverizer, to be crushed, and is sieved through 100 mesh sieve, bee is made
Rubber powder.
Preferably, the blending process includes following operation：The grape seed oil of predetermined weight number is weighed, material-compound tank is added
In, interlayer temperature 70 C is set, blender is started, waits for that temperature rises to 70 DEG C in material-compound tank, is added the beeswax of definite quality number,
Mixing speed 10-15rin/min is set, 20min is stirred, stops interlayer heating after beeswax all dissolving, is waited for warm in material-compound tank
When degree is down to 20 DEG C, it is slowly added into the apocynum extract and bee glue powder of predetermined weight number, stirs 15-30min, 80 mesh screens
It is spare in filtering to feed liquid bucket.
Preferably, the color water modulated process includes following operation：Take Brown Ferric Oxide and the temptation of predetermined weight number red,
It is added in 100 times of purified waters, stirs evenly, color water is made in the filtering of 100 mesh screens.
Preferably, describedization glue process includes following operation：In 18 DEG C -24 DEG C of temperature, relative humidity 45%-60% environment
Under, glycerine and the purifying of predetermined weight number is added after interlayer temperature rises to 65 DEG C in 65 DEG C of settingization glue tank interlayer temperature
The dosage of water, purified water is 100-150 parts, setting speed 30rin/min, opens stirring, and stirring to temperature in tank rises to 65 DEG C
When, the gelatin of predetermined weight number is slowly put into, 65 DEG C of constant temperature stir 2h, the color water modulated is added, stir 0.5h, keep stirring
It mixes and is warming up to 73 DEG C, constant temperature stirs 0.5h at 73 DEG C, and constant temperature stirs 0.5h after being warming up to 78 DEG C, is evacuated to -0.06-
0.08Mpa continues to stir 0.5h, exhaust 2-2.5h, stands 0.5-1h, glue is made, and glue obtained sieves with 100 mesh sieve net,
It is put into glue solution barrel, is kept the temperature under 60-65 DEG C of environment, it is spare.
Preferably, the pelletizing process includes following operation：At 18-23 DEG C of temperature, relative humidity 20-30% environment, open
Open encapsulating machine, 60-70 DEG C of setting expanding and arranging box temperature, 11-22 DEG C of idler wheel water temperature, 38-45 DEG C of injector temperature, every dress of adjustment
390-410mg is measured, and adjusting thickness handle makes rubber thickness be 0.78-0.80mm, starts pill, specification is 400mg/, is made
Soft capsule；
Preferably, the type-approval process includes following operation：The soft capsule suppressed is transported to conveyer belt in rolling cage, in temperature
26-30 DEG C of degree, in the environment of relative humidity 30-40%, 8rin/min shapes 1-3h；
Preferably, the wiping ball process includes following operation：Sterilizing is wiped ball and is arranged in 95% alcohol and is impregnated with, is then drained, it will
Wiping ball cloth after draining is put into rotating cage together with the soft capsule after sizing, starts rotating cage, wipes ball 30min；
Preferably, the drying process includes following operation：Soft capsule is placed in drying plant low temperature drying 35- after wiping ball
40h, temperature control is at 26-30 DEG C, relative humidity 30-35%；
Preferably, described that pill package process is selected to include following operation：Substandard and damaged soft capsule is sorted out, by the soft of qualification
Capsule packaging to get.
General flavone can improve high-density lipoprotein cholesterol in apocynum extract（HDL-C）, reduce low-density lipoprotein
White cholesterol（LDL-C）, body cholesterol level is reduced, reducing blood lipid, blood pressure lowering is effectively assisted to prevent the hair of cardiovascular and cerebrovascular disease
It is raw.Propolis contains very more Flavonoid substances and the active material with very strong anti-oxidation ability, can not only reduce
Harm of the lipid oxide to blood vessel prevents vascular sclerosis, and can also be effectively reduced triglyceride（TG）Content, reduce blood
Platelet is assembled, and improves microcirculation, reduces excessively high blood pressure.Linolenic acid in grape seed oil and procyanidine can resist certainly
By base, blood vessel elasticity is protected, reduces Blood Cholesterol, prevents thrombosis, blood vessel is expanded, effectively prevents cardiovascular and cerebrovascular disease
Generation.
The beneficial effects of the invention are as follows：Compared with prior art, a kind of bluish dogbane bee glue soft capsule of the invention and its system
Preparation Method, compatibility advantages of simple make one internal high density using 3 kinds of apocynum extract, bee glue powder, grape seed oil raw materials combinations
Lipoprotein liver sterol（HDL-C）It increases, low density lipoprotein cholesterol（LDL-C）It reduces, adjusts internal triglycerides（TG）'s
Metabolism reduces cholesterol level, while reducing lipid peroxidation substance, protects blood vessel elasticity, reduces blood pressure, assist reducing blood lipid
Meanwhile enhancing the defencive function of cardiovascular and cerebrovascular, fully and effectively prevent the generation of cardiovascular and cerebrovascular disease.
Specific implementation mode
A kind of 1 bluish dogbane bee glue soft capsule of embodiment
A kind of bluish dogbane bee glue soft capsule, is mainly made of content and rubber, and the content is mainly by following parts by weight
Raw material be made：9 parts of 56 parts of apocynum extract, 68 parts of bee glue powder, 265 parts of grape seed oil and beeswax；The rubber mainly by
The raw material of following parts by weight is made：Red 0.06 part and appropriate pure of 125 parts of gelatin, 50 parts of glycerine, 0.2 part of Brown Ferric Oxide, temptation
Change water.
A kind of preparation method of bluish dogbane bee glue soft capsule, it is characterised in that：It in turn includes the following steps：Prepare bluish dogbane
Extract, dispensing, the modulation of color water, changes glue, pill, sizing, wipes ball, drying, selects pill package propolis crushing.
It includes following operation to prepare apocynum extract process：Fresh Folium Apocyni Veneti is taken, is cleaned, is dried, be crushed to 10-
20 mesh；75% ethyl alcohol extract 3 times, every time 2 when；200 mesh refined filtration of ethanol extract recycles ethyl alcohol, 70-75 DEG C of vacuum decompression of filtrate
It is 1.05-1.06 medicinal extract to be concentrated into proportion, is spray-dried, and is crushed, and crosses 80 mesh sieve, apocynum extract is made.
Propolis crushing process includes following operation：The accurate propolis weighed after -18 DEG C of freezings, opens pulverizer, makes its sky
Turn 60s, confirm that machine is normal, propolis, which is poured into pulverizer, to be crushed, and is sieved through 100 mesh sieve, bee glue powder is made.
Blending process includes following operation：The grape seed oil of predetermined weight number is weighed, is added in material-compound tank, interlayer is set
Temperature 70 C starts blender, waits for that temperature rises to 70 DEG C in material-compound tank, and the beeswax of definite quality number, setting stirring speed is added
12rin/min is spent, 20min is stirred, stops interlayer heating after beeswax all dissolving, when temperature in material-compound tank is down to 20 DEG C,
It is slowly added into the apocynum extract and bee glue powder of predetermined weight number, stirs 20min, 80 mesh screens are filtered into feed liquid bucket,
It is spare.
Color water modulated process includes following operation：Take Brown Ferric Oxide and the temptation of predetermined weight number red, 100 times of addition is pure
Change in water, stir evenly, color water is made in the filtering of 100 mesh screens.
It includes following operation to change glue process：At 18 DEG C -24 DEG C of temperature, relative humidity 45%-60% environment, settingization glue tank
The glycerine and purified water of predetermined weight number, the dosage of purified water is added after interlayer temperature rises to 65 DEG C in 65 DEG C of interlayer temperature
It is 120 parts, setting speed 30rin/min, opens stirring and slowly put into predetermined weight when stirring rises to 65 DEG C to temperature in tank
The gelatin of number, 65 DEG C of constant temperature stir 2h, the color water modulated are added, stir 0.5h, be kept stirring and be warming up to 73 DEG C, in 73
Constant temperature stirs 0.5h at DEG C, and constant temperature stirs 0.5h after being warming up to 78 DEG C, is evacuated to -0.06-0.08Mpa, continues to stir 0.5h,
Exhaust 2h stands 0.8h, glue is made, glue obtained sieves with 100 mesh sieve net, is put into glue solution barrel, under 60-65 DEG C of environment
Heat preservation, it is spare.
Pelletizing process includes following operation：At 18-23 DEG C of temperature, relative humidity 20-30% environment, encapsulating machine is opened,
60-70 DEG C of expanding and arranging box temperature, 11-22 DEG C of idler wheel water temperature are set, 38-45 DEG C of injector temperature adjusts every loading amount 390-
410mg, and adjusting thickness handle makes rubber thickness be 0.78-0.80mm, starts pill, specification is 400mg/, and soft capsule is made；
Type-approval process includes following operation：The soft capsule suppressed is transported to conveyer belt in rolling cage, in 26-30 DEG C of temperature,
In the environment of relative humidity 30-40%, 8rin/min sizings 2h；
It includes following operation to wipe ball process：Sterilizing is wiped ball and is arranged in 95% alcohol and is impregnated with, is then drained, by the wiping after draining
Ball cloth is put into rotating cage together with the soft capsule after sizing, starts rotating cage, wipes ball 30min；
Drying process includes following operation：Soft capsule is placed in drying plant low temperature drying 35-40h after wiping ball, and temperature control exists
26-30 DEG C, relative humidity 30-35%；
It includes following operation to select pill package process：Substandard and damaged soft capsule is sorted out, qualified soft capsule is packed, i.e.,
?.
A kind of 2 bluish dogbane bee glue soft capsule of embodiment
A kind of bluish dogbane bee glue soft capsule, is mainly made of content and rubber, and the content is mainly by following parts by weight
Raw material be made：8 parts of 40 parts of apocynum extract, 50 parts of bee glue powder, 230 parts of grape seed oil and beeswax；The rubber mainly by
The raw material of following parts by weight is made：Red 0.045 part and appropriate of 100 parts of gelatin, 40 parts of glycerine, 0.15 part of Brown Ferric Oxide, temptation
Purified water.
The preparation method of embodiment 2 is substantially the same manner as Example 1, and difference lies in purifying water consumptions during changing glue to be
100 parts.
A kind of 3 bluish dogbane bee glue soft capsule of embodiment
A kind of bluish dogbane bee glue soft capsule, is mainly made of content and rubber, and the content is mainly by following parts by weight
Raw material be made：10 parts of 76 parts of apocynum extract, 85 parts of bee glue powder, 300 parts of grape seed oil and beeswax；The rubber mainly by
The raw material of following parts by weight is made：Red 0.075 part and appropriate of 150 parts of gelatin, 60 parts of glycerine, 0.25 part of Brown Ferric Oxide, temptation
Purified water.
The preparation method of embodiment 3 is substantially the same manner as Example 1, and difference lies in purifying water consumptions during changing glue to be
150 parts.
A kind of 1 bluish dogbane bee glue soft capsule of comparative example
A kind of bluish dogbane bee glue soft capsule, is mainly made of content and rubber, and the content is mainly by following parts by weight
Raw material be made：9 parts of 35 parts of apocynum extract, 45 parts of bee glue powder, 200 parts of grape seed oil and beeswax；2. the rubber is main
It is prepared from the following raw materials in parts by weight：Red 0.06 part and appropriate of 125 parts of gelatin, 50 parts of glycerine, 0.2 part of Brown Ferric Oxide, temptation
Purified water.
The preparation method of comparative example 1 is same as Example 1.
Difference lies in this 3 kinds of core materials of apocynum extract, bee glue powder and grape seed oil with embodiment 1 for comparative example 1
Dosage do not fall in the framework of the present definition.
1 lipid-lowering test of experimental example
Experimental method：The essentially identical male SD rat 60 of weight is chosen, is randomly divided into two groups, the 1st group 10 are normal group,
It feeds with basal feed, second group 50 are high in fat group, are fed with high lipid food.The mode of the free feeding of rat is taken, drinking-water is unlimited,
Rat body weight is recorded before experiment.After 60 days, whole Rat Fast 12h, blood sampling measures blood fat items physical signs with hemostix：
Serum total cholesterol（TC）, serum triglyceride（TG）, serum high-density LP（HDL-C）, serum low-density LP
（LDL-C）, and measure rat body weight.Experimental data carries out processing statistics.The results are shown in Table 1：
Table 1
| Index | Serum total cholesterol content（mmol/L） | Serum triglyceride content（mmol/L） | Serum High Density Lipoprotein Cholesterol content（mmol/L） | Serum LDL cholesterol content（mmol/L） |
| Normal group | 1.95±0.14 | 0.81±0.13 | 0.11±0.09 | 0.39±0.08 |
| High in fat group | 3.64±0.18 | 1.83±0.27 | 0.85±0.21 | 2.52±0.28 |
Wherein, basal feed is purchased from the double lion experimental animal feed technology Co., Ltds in Suzhou.Base of the high lipid food in basal feed
The cholic acid of the cholesterol of 1% basal feed quality, the lard of 10% basal feed quality, 0.1% basal feed quality is added on plinth
The albumen powder of salt, 10% basal feed quality.
Comparable 30 High fat diet rats of weight are chosen from above-mentioned group model high in fat, are divided into 5 groups, respectively S1 groups, S2
Group, S3 groups, D1 groups and control group high in fat choose comparable 6 normal rats of weight as normal from above-mentioned normal group model
Group, wherein S1 groups, S2 groups, S3 groups, D1 groups and the daily feeding high lipid food of control group high in fat, while the daily gavage of S1 group mouse is given
Bluish dogbane bee glue soft capsule made from medicine embodiment 1, bluish dogbane propolis made from the daily gastric infusion embodiment 2 of S2 group mouse are soft
Capsule, bluish dogbane bee glue soft capsule made from the daily gastric infusion embodiment 3 of S3 group mouse, the daily gastric infusion pair of D1 group mouse
Bluish dogbane bee glue soft capsule made from ratio 1；The daily feeding basal feed of mouse normally organized.It is raised according to the feeding manner
30 days, every mouse tail vein took blood, measured blood fat indices using blood fat instrument, experimental result is as shown in table 2：
Table 2
| Index | Serum total cholesterol content（mmol/L） | Serum triglyceride content（mmol/L） | Serum High Density Lipoprotein Cholesterol content（mmol/L） | Serum LDL cholesterol content（mmol/L） |
| Normal group | 1.99±0.22 | 0.95±0.08 | 1.17±0.16 | 0.41±0.12 |
| Control group high in fat | 3.88±0.21 | 1.97±0.14 | 0.80±0.12 | 2.68±0.19 |
| S1 groups | 1.99±0.17 | 0.96±0.04 | 1.17±0.20 | 0.69±0.06 |
| S2 groups | 2.00±0.15 | 0.97±0.10 | 1.02±0.21 | 0.72±0.11 |
| S3 groups | 2.01±0.12 | 0.97±0.17 | 1.04±0.12 | 0.73±0.15 |
| D1 groups | 2.83±0.21 | 1.42±0.12 | 0.91±0.08 | 2.27±0.02 |
As can be seen from Table 2, it is solid can to significantly reduce the total courage of serum for bluish dogbane bee glue soft capsule made from 1-3 of the embodiment of the present invention
It is solid to promote serum high-density LP courage for alcohol content, serum triglyceride content and serum LDL cholesterol content
Alcohol content；And comparative example 1 does not fall within this due to the dosage of apocynum extract, bee glue powder and grape seed oil this 3 kinds of core materials
In the range of invention limits, effect of drugs is caused obviously to be not so good as 1-3 of the embodiment of the present invention, it can be seen that raw material of the present invention is simple,
Compatibility is reasonable, and bluish dogbane bee glue soft capsule obtained is made using 3 kinds of apocynum extract, bee glue powder, grape seed oil raw materials combinations
High-density lipoprotein liver sterol in human body（HDL-C）It increases, low density lipoprotein cholesterol（LDL-C）It reduces, adjusts sweet in vivo
Oily three esters（TG）Metabolism, reduce cholesterol level, while reducing lipid peroxidation substance, protect blood vessel elasticity, reduce blood pressure,
While assisting reducing blood lipid, enhance the defencive function of cardiovascular and cerebrovascular, fully and effectively prevents the generation of cardiovascular and cerebrovascular disease.
Above-mentioned specific implementation mode is only the specific case of the present invention, and scope of patent protection of the invention includes but not limited to
The product form and style of above-mentioned specific implementation mode, any claims of the present invention and any technical field of meeting
The appropriate changes or modifications that those of ordinary skill does it, all shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of bluish dogbane bee glue soft capsule, is mainly made of content and rubber, it is characterised in that：The content mainly by
The raw material of following parts by weight is made：40-76 parts of apocynum extract, 50-85 parts of bee glue powder, 230-300 parts of grape seed oil and
8-10 parts of beeswax；The rubber is mainly prepared from the following raw materials in parts by weight：100-150 parts of gelatin, 40-60 parts of glycerine, palm fibre
0.15-0.25 parts of iron oxide, temptation red 0.045-0.075 parts and appropriate purified water.
2. a kind of bluish dogbane bee glue soft capsule as described in claim 1, it is characterised in that：The content is mainly by following heavy
The raw material of amount number is made：9 parts of 56 parts of apocynum extract, 68 parts of bee glue powder, 265 parts of grape seed oil and beeswax；The rubber
Mainly it is prepared from the following raw materials in parts by weight：125 parts of gelatin, 50 parts of glycerine, 0.2 part of Brown Ferric Oxide, temptation it is red 0.06 part and
Appropriate purified water.
3. a kind of preparation method of bluish dogbane bee glue soft capsule as described in claim 1, it is characterised in that：Include as follows successively
Step：Apocynum extract is prepared, propolis crushing, dispensing, the modulation of color water, changes glue, pill, sizing, wipes ball, drying, selects ball packet
Dress.
4. a kind of preparation method of bluish dogbane bee glue soft capsule as claimed in claim 3, it is characterised in that：The preparation is spreaded out
Nettle extract process includes following operation：Fresh Folium Apocyni Veneti is taken, is cleaned, is dried, be crushed to 10-20 mesh；75% ethyl alcohol extracts
3 times, every time 2 when；200 mesh refined filtration of ethanol extract, recycles ethyl alcohol, and 70-75 DEG C of vacuum-concentrcted of filtrate to proportion is 1.05-
1.06 medicinal extract are spray-dried, and are crushed, and cross 80 mesh sieve, apocynum extract is made.
5. a kind of preparation method of bluish dogbane bee glue soft capsule as claimed in claim 4, it is characterised in that：The propolis crushes
Process includes following operation：The accurate propolis weighed after -18 DEG C of freezings, opens pulverizer, makes its 30-80s that dallies, confirms machine
Normally, propolis is poured into pulverizer to crush, is sieved through 100 mesh sieve, bee glue powder is made.
6. a kind of preparation method of bluish dogbane bee glue soft capsule as claimed in claim 5, it is characterised in that：The blending process
Including operating as follows：The grape seed oil of predetermined weight number is weighed, is added in material-compound tank, interlayer temperature 70 C is set, starts and stir
Device is mixed, waits for that temperature rises to 70 DEG C in material-compound tank, is added the beeswax of definite quality number, sets mixing speed 10-15rin/min,
20min is stirred, stops interlayer heating after beeswax all dissolving, when temperature in material-compound tank is down to 20 DEG C, is slowly added into regulation
The apocynum extract and bee glue powder of parts by weight stir 15-30min, and 80 mesh screens are filtered into feed liquid bucket, spare.
7. a kind of preparation method of bluish dogbane bee glue soft capsule as claimed in claim 6, it is characterised in that：The color water modulation
Process includes following operation：It takes Brown Ferric Oxide and the temptation of predetermined weight number red, is added in 100 times of purified waters, stirs evenly,
100 mesh screens filter, and color water is made.
8. a kind of preparation method of bluish dogbane bee glue soft capsule as claimed in claim 7, it is characterised in that：Describedization glue process
Including operating as follows：At 18 DEG C -24 DEG C of temperature, relative humidity 45%-60% environment, 65 DEG C of settingization glue tank interlayer temperature waits for
After interlayer temperature rises to 65 DEG C, the glycerine and purified water of predetermined weight number is added, setting speed 30rin/min opens stirring,
When stirring rises to 65 DEG C to temperature in tank, the gelatin of predetermined weight number is slowly put into, 65 DEG C of constant temperature stir 2h, and addition modulates
Color water, stir 0.5h, be kept stirring and be warming up to 73 DEG C, at 73 DEG C constant temperature stir 0.5h, constant temperature stirs after being warming up to 78 DEG C
0.5h is mixed, -0.06-0.08Mpa is evacuated to, continues to stir 0.5h, exhaust 2-2.5h, stands 0.5-1h, glue, system is made
The glue obtained sieves with 100 mesh sieve net, is put into glue solution barrel, is kept the temperature under 60-65 DEG C of environment, spare.
9. a kind of preparation method of bluish dogbane bee glue soft capsule as claimed in claim 8, it is characterised in that：
The pelletizing process includes following operation：At 18-23 DEG C of temperature, relative humidity 20-30% environment, encapsulating machine is opened,
60-70 DEG C of expanding and arranging box temperature, 11-22 DEG C of idler wheel water temperature are set, 38-45 DEG C of injector temperature adjusts every loading amount 390-
410mg, and adjusting thickness handle makes rubber thickness be 0.78-0.80mm, starts pill, specification is 400mg/, and soft capsule is made；
The type-approval process includes following operation：The soft capsule suppressed is transported to conveyer belt in rolling cage, in temperature 26-30
DEG C, in the environment of relative humidity 30-40%, 8rin/min sizings 1-3h；
The wiping ball process includes following operation：Sterilizing is wiped ball and is arranged in 95% alcohol and is impregnated with, is then drained, after draining
Wiping ball cloth be put into rotating cage together with the soft capsule after sizing, start rotating cage, wipe ball 30min；
The drying process includes following operation：Soft capsule is placed in drying plant low temperature drying 35-40h, temperature control after wiping ball
System is at 26-30 DEG C, relative humidity 30-35%；
It is described that pill package process is selected to include following operation：Substandard and damaged soft capsule is sorted out, by qualified soft capsule packet
Dress to get.
10. a kind of preparation method of bluish dogbane bee glue soft capsule as claimed in claim 8, it is characterised in that：The use of purified water
Amount is 100-150 parts.
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| KR101503834B1 (en) * | 2012-09-19 | 2015-03-24 | 대구한의대학교산학협력단 | A composition comprising a crude extract or purified fraction extract of Plantago asiatica for treating or preventing hyperlipidemia and obesity |
| CN106943372A (en) * | 2017-03-16 | 2017-07-14 | 于桐浩 | A kind of auxiliary hyperglycemic soft capsule and its production technology |
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| CN102771786A (en) * | 2012-06-29 | 2012-11-14 | 安徽省王巢食品有限公司 | Propolis and lucid ganoderma soft capsule with health care function and preparation method of propolis and lucid ganoderma soft capsule |
| KR101503834B1 (en) * | 2012-09-19 | 2015-03-24 | 대구한의대학교산학협력단 | A composition comprising a crude extract or purified fraction extract of Plantago asiatica for treating or preventing hyperlipidemia and obesity |
| CN106943372A (en) * | 2017-03-16 | 2017-07-14 | 于桐浩 | A kind of auxiliary hyperglycemic soft capsule and its production technology |
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Application publication date: 20181106 |