CN106109488A - The application in preparing the food or medicine with blood fat reducing function of a kind of Quinoa polysaccharide - Google Patents
The application in preparing the food or medicine with blood fat reducing function of a kind of Quinoa polysaccharide Download PDFInfo
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- CN106109488A CN106109488A CN201610710973.3A CN201610710973A CN106109488A CN 106109488 A CN106109488 A CN 106109488A CN 201610710973 A CN201610710973 A CN 201610710973A CN 106109488 A CN106109488 A CN 106109488A
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- quinoa
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- 150000004676 glycans Chemical class 0.000 title claims abstract description 82
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- 210000004369 blood Anatomy 0.000 title claims abstract description 34
- 239000008280 blood Substances 0.000 title claims abstract description 34
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 79
- 239000006228 supernatant Substances 0.000 claims description 52
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- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
Abstract
The invention provides the application in preparing the food or medicine with blood fat reducing function of a kind of Quinoa polysaccharide.The present invention has investigated the Quinoa polyoses extract effect for reducing blood fat to hyperlipemia rat model.Result shows, Quinoa polysaccharide has significant effect for reducing blood fat, has bright market prospects.The present invention opens the new application of Quinoa polysaccharide, all has good value of exploiting and utilizing on health food and drug market, and application space is wide.
Description
Technical field
The invention belongs to food and field of pharmaceutical technology, be specifically related to a kind of Quinoa polysaccharide, in preparation, there is blood fat reducing function
Food or medicine in application.
Background technology
Hyperlipemia is a kind of common and multiple metabolic disease, be the significant risk causing cardiovascular and cerebrovascular disease because of
Element, is common in middle-aged and elderly people, but along with dietary structure and the change of living habit, prevalence is also gradually increased in adolescence.
The treatment of hyperlipemia at present has become the problem that medical circle pays high attention to.In the market antihyperlipidemic product mainly with Statins,
Fibrates Western medicine is main, but great majority have side effect, such as, increase the weight of gastric ulcer and cause gastrointestinal irritation, make carbohydrate tolerance reduction cause
Diabetes, increase uric acid cause gout, and severe patient even can cause irreversibility hepatic injury, and relapse rate is of a relatively high, unsuitable
Long-term taking.Ancient Times in China just has the record using plant extract to reduce blood fat, therefore finds new from conventional medicament and plant
Natural Lipid-lowering activities composition be treatment hyperlipemia an important channel, therefore from natural plants screen research and development there is safety
Efficient blood lipid-lowering medicine or edible health product tool are of great significance.
Quinoa (Chenopodium quinoa Willd.), also known as South America Herba chenopodii, Kui Herba chenopodii, Herba chenopodii paddy, quinoa etc., is 1 year
Raw Chenopodiaceae (Chenopodiaceae) herbaceous crops, originates in mountain area, South America Andean, the most more than 5000～7000
The utilization in year and plantation history, be referred to as " mother of corn " by Inca.Quinoa seed is gone back rich in protein, carotenoid
And Vc, the composition equilibrium of its Amino Acids in Proteins, simultaneously rich in trace element, its content apparently higher than most of common corn,
Thus regarded as a kind of solitary plant meeting human body basic nutrition demand by the United Nations, it is referred to as by international nutritionist
" super corn ".Modern study also finds wherein containing abundant Polyphenols, flavonoid, saponins isoreactivity composition, have antioxidation,
The multiple biological activitys such as antiinflammatory, blood sugar lowering, fat-reducing, for maintaining the healthy of the mankind to have a very important role.Early stage
Research display, containing abundant water soluble polysaccharide in Quinoa, but yet there are no the report that Quinoa polysaccharide is applied to blood fat reducing.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is to provide a kind of Quinoa polysaccharide to have blood fat reducing merit in preparation
Application in the food of effect or medicine, the Quinoa polysaccharide that the present invention provides has good effect for reducing blood fat.
The invention provides the application in preparing the food or medicine with blood fat reducing function of a kind of Quinoa polysaccharide.
Preferably, the dosage form of the medicine described in blood fat reducing function is selected from tablet, granule, pill, capsule, is administered orally
Liquid or soft extract.
Preferably, described Quinoa polysaccharide uses decocting method extraction, supersound extraction, microwave extraction or pressurized solvent method to extract.
Preferably, described decocting method extract particularly as follows:
After Quinoa after pulverizing carries out circumfluence distillation 0.5～2h after mixing with water, filter and be centrifuged, obtain supernatant
Liquid；
Carrying out precipitate with ethanol by adding dehydrated alcohol after described supernatant concentration, stand 1～6h, sucking filtration must precipitate, washing and drying,
Obtain Quinoa polysaccharide.
Preferably, described supersound extraction particularly as follows:
Quinoa and water Hybrid Heating after pulverizing, carries out supersound extraction 1～2 times, after each 1～3 hour, filter and from
The heart, obtains supernatant；
By precipitate with ethanol after described supernatant concentration, standing 1～6h, sucking filtration must precipitate, washing and drying, obtains Quinoa polysaccharide.
Preferably, described microwave extraction particularly as follows:
Will pulverize after Quinoa mix with the ethanol water that volume fraction is 0%～20%, employing power be 300～
The microwave extraction 1 of 700W～2 times, after extracting 0.5～1h every time, filter and be centrifuged, obtain supernatant；
By precipitate with ethanol after described supernatant concentration, standing 1～6h, sucking filtration must precipitate, washing and drying, obtains Quinoa polysaccharide.
Preferably, described pressurized solvent method extract particularly as follows:
Quinoa after pulverizing mixes with water, is placed in sealing pressing extractor, at 2.0～8.0kg cm-2Pressure strip
Carry out pressurization extraction 1～2 time under part, after extracting 0.5～1h every time, filter and be centrifuged, obtain supernatant；
By precipitate with ethanol after described supernatant concentration, standing 1～6h, sucking filtration must precipitate, washing and drying, obtains Quinoa polysaccharide.
Preferably, after washing and drying, also include:
Product after drying mixes redissolution with water, obtains mixed solution；
Addition 1～the chitosan flocculant of 3% bulking value specific concentration in described mixed solution, flocculation 24～48h,
To reactant liquor；Described mixed solution is 1:(0.1～0.2 with the mass ratio of described chitosan flocculant)；
Described reactant liquor is centrifuged 1～2 time under 3000～5000r/min, each 10～30min, obtains the supernatant；
The described supernatant is dried.
Preferably, the dosage of described Quinoa polysaccharide is 2～20g/kg.
Compared with prior art, the invention provides a kind of Quinoa polysaccharide and there is in preparation food or the medicine of blood fat reducing function
Application in product.The present invention has investigated the Quinoa polyoses extract effect for reducing blood fat to hyperlipemia rat model.Result shows, Herba chenopodii
Wheat polysaccharide has significant effect for reducing blood fat, has bright market prospects.The present invention opens the new application of Quinoa polysaccharide, in health care
All having good value of exploiting and utilizing on food and drug market, application space is wide.
Accompanying drawing explanation
Fig. 1 is the hepatic pathology change photo of Normal group；
Fig. 2 is the hepatic pathology change photo of model group；
Fig. 3 is the hepatic pathology change photo of positive controls；
Fig. 4 is the hepatic pathology change photo of Quinoa polysaccharide low dose group；
Fig. 5 is the hepatic pathology change photo of Quinoa polysaccharide high dose group.
Detailed description of the invention
The invention provides the application in preparing the food or medicine with blood fat reducing function of a kind of Quinoa polysaccharide.
In the Quinoa polysaccharide provided in present invention application in preparation has the food of blood fat reducing function or medicine, described
Quinoa polysaccharide is used for blood fat reducing, has good health protection and therapeutic action to cardiovascular disease.Preferably, described Quinoa polysaccharide is used for
The medicine of the cardiovascular disease such as preparation treatment or the prevention coronary heart disease relevant to hyperlipidemia, atherosclerosis or food.
Wherein, the present invention does not has particular restriction to the dosage form of the described medicine with blood fat reducing function, is preferably oral
Dosage form, more preferably tablet, granule, pill, capsule, oral liquid or soft extract.
Preferably, the dosage of described Quinoa polysaccharide is 2～20g/kg, preferably 5～10g/kg.
In the present invention, described Quinoa polysaccharide uses decocting method extraction, supersound extraction, microwave extraction or pressurized solvent method to carry
Take.
Preferably, described decocting method extract particularly as follows:
After Quinoa after pulverizing carries out circumfluence distillation 0.5～2h after mixing with water, filter and be centrifuged, obtain supernatant
Liquid；
Carrying out precipitate with ethanol by adding dehydrated alcohol after described supernatant concentration, stand 1～6h, sucking filtration must precipitate, washing and drying,
Obtain Quinoa polysaccharide.
Concrete, first Quinoa seed is pulverized by the present invention, obtains the Quinoa powder of 10～150 mesh.
Being mixed with water by described Quinoa powder, obtain mixture, described Quinoa powder soaks in water.Wherein, described Herba chenopodii
Flour end is 1:(10～30 with the mass ratio of water), preferably 1:20.
After described mixture is carried out circumfluence distillation 0.5～2h, filter and be centrifuged, obtain supernatant；
Then, described supernatant is concentrated, obtains concentrated solution.Described concentrated solution is excellent with the volume ratio of described supernatant
Elect 1:(5～10 as)
In described concentrated solution add dehydrated alcohol carry out precipitate with ethanol, it is preferred that described dehydrated alcohol account for described concentrated solution with
The volume fraction of the mixed solution of described dehydrated alcohol is 70%～85%.
After precipitate with ethanol, carry out standing 1～6 hour by the mixed solution obtained, in the present invention, it is preferred to enter under cryogenic
Row stands, and the temperature of described standing is preferably 4～15 DEG C.
After standing terminates, carry out sucking filtration, be precipitated thing.
Then, described precipitate is washed and dries, obtain Quinoa polysaccharide.The present invention is to described washing and drying
Method does not has particular restriction, well known to a person skilled in the art method.
Preferably, described supersound extraction particularly as follows:
Quinoa and water Hybrid Heating after pulverizing, carries out supersound extraction 1～2 times, after each 1～3 hour, filter and from
The heart, obtains supernatant；
Carrying out precipitate with ethanol by adding dehydrated alcohol after described supernatant concentration, stand 1～6h, sucking filtration must precipitate, washing and drying,
Obtain Quinoa polysaccharide.
Concrete, first Quinoa seed is pulverized by the present invention, obtains the Quinoa powder of 10～150 mesh.
Being mixed with water by described Quinoa powder, obtain mixture, described Quinoa powder soaks in water.Wherein, described Herba chenopodii
Flour end is 1:(10～30 with the mass ratio of water), preferably 1:20.
Described mixture is carried out supersound extraction 1～2 times, after each 1～3 hour, filters and be centrifuged, obtain supernatant.
In the present invention, described ultrasonic frequency is preferably 20～100kHz
Then, described supernatant is concentrated, obtains concentrated solution.Described concentrated solution is excellent with the volume ratio of described supernatant
Elect 1:(5～10 as).
In described concentrated solution add dehydrated alcohol carry out precipitate with ethanol, it is preferred that described dehydrated alcohol account for described concentrated solution with
The volume fraction of the mixed solution of described dehydrated alcohol is 70%～85%.
After precipitate with ethanol, carry out standing 1～6 hour by the mixed solution obtained, in the present invention, it is preferred to enter under cryogenic
Row stands, and the temperature of described standing is preferably 4～15 DEG C.
After standing terminates, carry out sucking filtration, be precipitated thing.
Then, described precipitate is washed and dries, obtain Quinoa polysaccharide.The present invention is to described washing and drying
Method does not has particular restriction, well known to a person skilled in the art method.
Preferably, described microwave extraction particularly as follows:
Will pulverize after Quinoa mix with the ethanol water that volume fraction is 0%～20%, employing power be 300～
The microwave extraction 1 of 700W～2 times, after extracting 0.5～1h every time, filter and be centrifuged, obtain supernatant；
Carrying out precipitate with ethanol by adding dehydrated alcohol after described supernatant concentration, stand 1～6h, sucking filtration must precipitate, washing and drying,
Obtain Quinoa polysaccharide.
Concrete, first Quinoa seed is pulverized by the present invention, obtains the Quinoa powder of 10～150 mesh.
Described Quinoa powder is mixed with the ethanol water that volume fraction is 0%～20%, obtains mixture, described Herba chenopodii
Flour end is soaked in the ethanol water that volume fraction is 0%～20%.Wherein, described Quinoa powder with the mass ratio of water is
1:(10～30), preferably 1:20.
Described mixture is carried out microwave extraction 1～2 times, after each 0.5～1 hour, filters and be centrifuged, obtain supernatant
Liquid.The power of described microwave is preferably 700W.
Then, described supernatant is concentrated, obtains concentrated solution.Described concentrated solution is excellent with the volume ratio of described supernatant
Elect 1:(5～10 as).
In described concentrated solution, add dehydrated alcohol carry out precipitate with ethanol, it is preferred that described concentrated solution and described dehydrated alcohol
In mixed solution, the volume fraction of ethanol is 70%～85%.
After precipitate with ethanol, carry out standing 1～6 hour by the mixed solution obtained, in the present invention, it is preferred to enter under cryogenic
Row stands, and the temperature of described standing is preferably 4～15 DEG C.
After standing terminates, carry out sucking filtration, be precipitated thing.
Then, described precipitate is washed and dries, obtain Quinoa polysaccharide.The present invention is to described washing and drying
Method does not has particular restriction, well known to a person skilled in the art method.
Preferably, described pressurized solvent method extract particularly as follows:
Quinoa after pulverizing mixes with water, is placed in sealing pressing extractor, at 2.0～8.0kg cm-2Pressure strip
Carry out pressurization extraction 1～2 time under part, after extracting 0.5～1h every time, filter and be centrifuged, obtain supernatant；
Carrying out precipitate with ethanol by adding dehydrated alcohol after described supernatant concentration, stand 1～6h, sucking filtration must precipitate, washing and drying,
Obtain Quinoa polysaccharide.
Concrete, first Quinoa seed is pulverized by the present invention, obtains the Quinoa powder of 10～150 mesh.
Being mixed with water by described Quinoa powder, obtain mixture, described Quinoa powder soaks in water.Wherein, described Herba chenopodii
Flour end is 1:(10～30 with the mass ratio of water), preferably 1:20.
Described mixture is placed in sealing pressing extractor, at 2.0～8.0kg cm-2Pressure condition under add
Pressure extraction 1～2 time, after extracting 0.5～1h every time, filters and is centrifuged, obtain supernatant.
Then, described supernatant is concentrated, obtains concentrated solution.Described concentrated solution is excellent with the volume ratio of described supernatant
Elect 1:(5～10 as).
In described concentrated solution add dehydrated alcohol carry out precipitate with ethanol, it is preferred that described dehydrated alcohol account for described concentrated solution with
The volume fraction of the mixed solution of described dehydrated alcohol is 70%～85%.
After precipitate with ethanol, carry out standing 1～6 hour by the mixed solution obtained, in the present invention, it is preferred to enter under cryogenic
Row stands, and the temperature of described standing is preferably 4～15 DEG C.
After standing terminates, carry out sucking filtration, be precipitated thing.
Then, described precipitate is washed and dries, obtain Quinoa polysaccharide.The present invention is to described washing and drying
Method does not has particular restriction, well known to a person skilled in the art method.
In the extracting method of above-mentioned four kinds of Quinoa polysaccharide, after washing and drying, also include:
Product after drying mixes redissolution with water, obtains mixed solution；
Addition 1～the chitosan flocculant of 3% bulking value specific concentration in described mixed solution, flocculation 24～48h,
To reactant liquor；Described mixed solution is 1:(0.1～0.2 with the mass ratio of described chitosan flocculant)；
Described reactant liquor is centrifuged 1～2 time under 3000～5000r/min, each 10～30min, obtains the supernatant；
The described supernatant is dried, obtains Quinoa polysaccharide.
The present invention has investigated the Quinoa polyoses extract effect for reducing blood fat to hyperlipemia rat model.Result shows, Quinoa
Polysaccharide has significant effect for reducing blood fat, has bright market prospects.The present invention opens the new application of Quinoa polysaccharide, at health care food
All having good value of exploiting and utilizing on product and drug market, application space is wide.
In order to be further appreciated by the present invention, the Quinoa polysaccharide provided the present invention below in conjunction with embodiment has fall in preparation
Application in the food of blood fat effect or medicine illustrates, and protection scope of the present invention is not limited by the following examples.
Embodiment 1
Prepared by Quinoa polyoses extract
Weighing Quinoa seed, pulverizing is the powder of 10～150 mesh, adds 20 times of water soakings, heats back mixture
Stream extracts 2h, filters and is centrifuged, takes supernatant, reaches add ethanol to containing alcohol volume ratio after supernatant concentration at 80%, low gentle and quiet
Putting 6h, sucking filtration must precipitate, and washing and drying i.e. obtains Quinoa polysaccharide.
Quinoa polysaccharide after above-mentioned drying is mixed with water, obtains the Quinoa polysaccharide solution that concentration is 1g/mL.
Embodiment 2
1, material
Take that upgrowth situation is good, body weight is about 200g male rat, Sichuan Province's Experimental Animal Center provide.
The Quinoa polyoses extract (1g/ml) of embodiment 1 preparation；
Simvastatin Tablets, is produced by Shanghai Xinyi Wanxiang Pharmaceutical Co., Ltd., and compound concentration is 1mg/ml；
Normal saline.
2, the preparation of high lipid food
Formula: (Chengdu, Sichuan reaches rich fruit and tests Company of Animals Ltd., feedstuff model: 8061 basis mixed fodder, performs mark
Accurate: GB 14924.3-2010) 88.5%, Adeps Sus domestica 10%, cholesterol 1%, Fel Sus domestica salt 0.5%.
Collocation method: add cholesterol after being dissolved in water-bath by Adeps Sus domestica, Fel Sus domestica salt is adjusted and mixed uniformly, then mixes with normal feedstuff
Even, it is placed in 80 DEG C of drying in thermostatic drying chamber, standby.
3, animal packet and experimental technique
Take after 50 rat adaptabilities raise one week, be randomly divided into 5 groups, respectively Normal group, model group, positive right
According to group (simvastatin), Quinoa polysaccharide high dose group, Quinoa polysaccharide low dose group.
Wherein, the rat that based on Normal group, mixed fodder is fed, gavage normal saline during experiment；
Model group is the rat that high lipid food is fed, gavage normal saline during experiment；
Positive controls is the rat that high lipid food is fed, the simvastatin solution of gavage 3mg/kg during experiment；
Quinoa polysaccharide high dose group is the rat that high lipid food is fed, and during experiment, the Quinoa polysaccharide of gavage 10g/kg is molten
Liquid；
Quinoa polysaccharide low dose group is the rat that high lipid food is fed, the Quinoa polysaccharide solution of gavage 5g/kg during experiment.
In addition to Normal group uses normal feedstuff and raises, remaining animal all uses high lipid food to feed, and raises 1 continuously
Month, only control feedstuff 20g/ every day.Take a small amount of blood and survey Triglycerides in Serum and cholesterol level, it is judged that whether its modeling becomes
Merit.
On the basis of hyperlipemia model, gavage gives medicine, every day 1 time, successive administration 1 month, within every two days, weighs, meter
Calculate each group of rat body weight rate of increase.First 1 day of off-test, water is can't help in fasting, and femoral artery takes blood, surveys Triglycerides in Serum, total
The index content such as cholesterol, high density lipoprotein, low density lipoprotein, LDL.With SPSS 17.0 statistical software analytical data, result with
Mean ± SD represents.Experimental result is shown in Tables 1 and 2, the table 1 Quinoa of the present invention polysaccharide serum glycerol three to high blood lipid model rat
The impact (n=10) of ester and T-CHOL
The table 1 Quinoa of the present invention polysaccharide serum triglycerides on high blood lipid model rat and the impact of T-CHOL
Compare with model group,▲P < 0.05, has significant difference.
The table 2 Quinoa polysaccharide serum high-density LP on high blood lipid model rat and the impact of low density lipoprotein, LDL
Compare with model group,▲P < 0.05, has significant difference.
From Tables 1 and 2, Quinoa polysaccharide has significant effect for reducing blood fat.
Embodiment 3
1, material
Take that upgrowth situation is good, body weight is about 200g male rat, Sichuan Province's Experimental Animal Center provide.
The Quinoa polyoses extract (1g/ml) of embodiment 1 preparation；
Simvastatin Tablets, is produced by Shanghai Xinyi Wanxiang Pharmaceutical Co., Ltd., and compound concentration is 1mg/ml；
Normal saline.
2, animal packet and experimental technique
Take after 50 rat adaptabilities raise one week, be randomly divided into 5 groups, respectively Normal group, model group, positive right
According to group (simvastatin), Quinoa polysaccharide high dose group, Quinoa polysaccharide low dose group.
Wherein, the rat that based on Normal group, mixed fodder is fed, gavage normal saline during experiment；
Model group is the rat that high lipid food is fed, gavage normal saline during experiment；
Positive controls is the rat that high lipid food is fed, the simvastatin solution of gavage 3mg/kg during experiment；
Quinoa polysaccharide high dose group is the rat that high lipid food is fed, and during experiment, the Quinoa polysaccharide of gavage 10g/kg is molten
Liquid；
Quinoa polysaccharide low dose group is the rat that high lipid food is fed, the Quinoa polysaccharide solution of gavage 5g/kg during experiment.
In addition to Normal group uses normal feedstuff and raises, remaining animal all uses high lipid food to feed, and raises 1 continuously
Month, only control feedstuff 20g/ every day.Take a small amount of blood and survey Triglycerides in Serum and cholesterol level, it is judged that whether its modeling becomes
Merit.
Being fixed through 4% paraformaldehyde by above-mentioned five groups of rat livers after raising, gradient alcohol dehydration, toluene is saturating
Bright, paraffin embedding, 5 μm section (Leica, RM2235, Germany), HE dyes, and om observation records pathology this pathology of various kinds
Change, and take pictures (Nikon eclipse 55i, Japan) with micro imaging system.Result is shown in that Fig. 1～Fig. 5, Fig. 1 are the most right
Taking the hepatic pathology change picture of group, in Fig. 1, Normal group liver has no obvious pathological change (HE × 400).
Fig. 2 is the hepatic pathology change photo of model group, in Fig. 2, model group liver liver rope arrangement disorder, sinus hepaticus locking.
Severe hepatic cell enlargement, severe big vesicle mixed type steatosis, little alveolitoid is main (HE × 400).
Fig. 3 is the hepatic pathology change photo of positive controls, and in Fig. 3, the arrangement of positive controls hepatic portion liver rope is disorderly
Disorderly, hepatocyte granular degeneration and slight little alveolitoid steatosis (HE × 400).
Fig. 4 is the hepatic pathology change photo of Quinoa polysaccharide low dose group；In Fig. 4, Quinoa polysaccharide low dose group liver liver
Cell moderate swelling, moderate big vesicle mixed type steatosis, little alveolitoid is main (HE × 400).
Fig. 5 is the hepatic pathology change photo of Quinoa polysaccharide high dose group, in Fig. 5, Quinoa polysaccharide high dose group liver liver
Cell silght enlargement, liver moderate mixed type steatosis, little alveolitoid is main (HE × 400).
From Fig. 1～Fig. 5, Quinoa polysaccharide high and low dose all shows improves hyperlipidemia animal livers characteristics of lesion, its
Middle Quinoa high dose group action intensity is close with positive drug, it was demonstrated that the effect for reducing blood fat of Quinoa polysaccharide.
Embodiment 4
The decoction extraction process of Quinoa polysaccharide
Weighing Quinoa seed, pulverizing is 10 mesh powder, adds 10 times of water soakings, mixture is carried out circumfluence distillation
0.5h, filters and is centrifuged, take supernatant, adds ethanol to containing alcohol volume ratio and reach 75% after suitably concentrating, stand at low temperature 3h, sucking filtration
Must precipitate, washing and drying, add 0.1% chitosan flocculant, centrifuging and taking supernatant after redissolution, cold drying i.e. obtains Quinoa polysaccharide.
Embodiment 5
The ultrasonic extraction process of Quinoa polysaccharide
Weighing Quinoa seed, pulverizing is 80 mesh powder, with 20 times of water soakings, mixture carries out warm macerating (90 DEG C) is ultrasonic to be carried
Take 2h, filter and be centrifuged, take supernatant, add ethanol to containing alcohol volume ratio after suitably concentrating and reach 75%, stand at low temperature 6h, sucking filtration
Must precipitate, washing and drying, add 0.1% chitosan flocculant, centrifuging and taking supernatant after redissolution, cold drying i.e. obtains Quinoa polysaccharide.
Embodiment 6
The microwave extraction technique of Quinoa polysaccharide
Weighing Quinoa seed, pulverizing is 150 mesh powder, adds 30 times of 10% soak with ethanol, uses 700W microwave extraction 2
Secondary, extract 0.5h every time, filter and be centrifuged, take supernatant, add ethanol after suitably concentrating and reach 70% to containing alcohol volume ratio, low temperature
Standing 6h, sucking filtration must precipitate, and adds 0.1% chitosan flocculant, centrifuging and taking supernatant after redissolution, and it is many that cold drying i.e. obtains Quinoa
Sugar.
Embodiment 7
The pressurised extraction technique of Quinoa polysaccharide
Weighing Quinoa seed, pulverizing is 100 mesh powder, with 20 times of water soakings, is placed in sealing pressing extractor and adds
Pressure extraction (8.0kg cm-2) 2 times, extract 0.5h every time, filter and be centrifuged, take supernatant, add ethanol after suitably concentrating to containing
Alcohol volume ratio reaches 75%, stand at low temperature 4h, and sucking filtration must precipitate, and adds 0.1% chitosan flocculant after redissolution, centrifuging and taking supernatant,
Cold drying i.e. obtains Quinoa polysaccharide.
Embodiment 8
The preparation of Quinoa polysaccharide tablet
The arbitrary described Quinoa polyoses extract of Example 4 is appropriate, and (50:30:10:5) adds starch, micro-by a certain percentage
Crystalline cellulose, polyvinylpolypyrrolidone also mix, wet granulation, dry, add 5% magnesium stearate as lubricant, are pressed into tablet,
Film coating and get final product.
Embodiment 9
The preparation of the many candy pills of Quinoa
In Example 4, arbitrary described Quinoa polyoses extract is appropriate, is ground into fine powder, sieves.Take sucrose to be dissolved in water,
It is about 1.35 (70 DEG C) with refined honey mixing refining to relative honey degree, filters, mix according to weight ratio 100:40 with said extracted thing fine powder
Even, pill block, rub ball bar, pill grain with the hands.
Embodiment 10
The preparation of Quinoa polysaccharide gum wafer
In Example 4, arbitrary described Quinoa polyoses extract is appropriate, and (100:80:20) adds manna by a certain percentage
Alcohol, polyvidone, wet granulation or micropill processed, use the encapsulation of 1# hard capsule case.
Embodiment 11
The preparation of Quinoa polyoses grain agent
In Example 4, arbitrary described Quinoa polyoses extract is appropriate, and (100:75:25) adds manna by a certain percentage
Alcohol, microcrystalline Cellulose, wet granulation, pack.
Embodiment 12
The preparation of Quinoa polyoses oral liquid
In Example 4, arbitrary described Quinoa polyoses extract is appropriate, adds sucrose 3.0%, Mel 1.5%, citric acid
0.05%, pack.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (9)
1. the Quinoa polysaccharide application in preparation has the food of blood fat reducing function or medicine.
Application the most according to claim 1, it is characterised in that described in there is the dosage form of medicine of blood fat reducing function selected from sheet
Agent, granule, pill, capsule, oral liquid or soft extract.
Application the most according to claim 1, it is characterised in that described Quinoa polysaccharide use decocting method extraction, supersound extraction,
Microwave extraction or pressurized solvent method are extracted.
Application the most according to claim 3, it is characterised in that described decocting method extract particularly as follows:
After Quinoa after pulverizing carries out circumfluence distillation 0.5～2h after mixing with water, filter and be centrifuged, obtain supernatant；
Carrying out precipitate with ethanol by adding dehydrated alcohol after described supernatant concentration, stand 1～6h, sucking filtration must precipitate, and washing and drying obtains
Quinoa polysaccharide.
Application the most according to claim 3, it is characterised in that described supersound extraction particularly as follows:
Quinoa and water Hybrid Heating after pulverizing, carries out supersound extraction 1～2 times, after each 1～3 hour, filters and be centrifuged,
Obtain supernatant；
By precipitate with ethanol after described supernatant concentration, standing 1～6h, sucking filtration must precipitate, washing and drying, obtains Quinoa polysaccharide.
Application the most according to claim 3, it is characterised in that described microwave extraction particularly as follows:
Quinoa after pulverizing mixes with the ethanol water that volume fraction is 0%～20%, and using power is 300～700W
Microwave extraction 1～2 times, after extracting 0.5～1h every time, filter and be centrifuged, obtain supernatant；
By precipitate with ethanol after described supernatant concentration, standing 1～6h, sucking filtration must precipitate, washing and drying, obtains Quinoa polysaccharide.
Application the most according to claim 3, it is characterised in that described pressurized solvent method extract particularly as follows:
Quinoa after pulverizing mixes with water, is placed in sealing pressing extractor, at 2.0～8.0kg cm-2Pressure condition under
Carry out pressurization extraction 1～2 time, after extracting 0.5～1h every time, filter and be centrifuged, obtain supernatant；
By precipitate with ethanol after described supernatant concentration, standing 1～6h, sucking filtration must precipitate, washing and drying, obtains Quinoa polysaccharide.
8. according to the application described in claim 4～7 any one, it is characterised in that after washing and drying, also include:
Product after drying mixes redissolution with water, obtains mixed solution；
Addition 1～the chitosan flocculant of 3% bulking value specific concentration, flocculation 24～48h in described mixed solution, obtain anti-
Answer liquid；Described mixed solution is 1:(0.1～0.2 with the mass ratio of described chitosan flocculant)；
Described reactant liquor is centrifuged 1～2 time under 3000～5000r/min, each 10～30min, obtains the supernatant；
The described supernatant is dried.
Application the most according to claim 1, it is characterised in that the dosage of described Quinoa polysaccharide is 2～20g/kg.
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| CN106509615A (en) * | 2016-11-20 | 2017-03-22 | 青海泰柏特生物科技有限公司 | Chenopodium quinoa willd soft capsules rich in resveratrol and preparation method of chenopodium quinoa willd soft capsules |
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| CN107347957A (en) * | 2017-07-25 | 2017-11-17 | 合肥台香食品有限公司 | A kind of processing method of the excellent quinoa coarse cereals bread of storage performance |
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