CN108704049A - A kind of preparation method of Chinese medicine composition and its health food with anti-oxidation function - Google Patents
A kind of preparation method of Chinese medicine composition and its health food with anti-oxidation function Download PDFInfo
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- CN108704049A CN108704049A CN201810949246.1A CN201810949246A CN108704049A CN 108704049 A CN108704049 A CN 108704049A CN 201810949246 A CN201810949246 A CN 201810949246A CN 108704049 A CN108704049 A CN 108704049A
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- honeysuckle
- berry
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- chinese medicine
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Toxicology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides the preparation methods of a kind of Chinese medicine composition with anti-oxidation function and its health food, belong to technical field of functional food, which includes the raw material of following parts by weight：3~45 parts of honeysuckle, 1~9 part of purple perilla, 1~12 part of Rhizoma Chuanxiong, 1~21 part of the root bark of Chinese wolf-berry, 1~18 part of rhizoma cyperi.The formula composition of the Chinese medicine composition of the present invention is theoretical according to traditional Chinese medicine anti-aging, is further screened and is analyzed by modern pharmacology, using honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry, rhizoma cyperi as primary raw material.The main component of the Chinese medicine composition of the present invention is Flavonoid substances, can be used for alleviating the symptoms such as skin aging, blood vessel aging, organ failure caused by people's interior free yl increase.Meanwhile showing the health food edible safety with anti-oxidation function that the present invention is prepared through toxicology test, it has no toxic side effect.
Description
Technical field
The present invention relates to technical field of functional food more particularly to a kind of Chinese medicine compositions and guarantor with anti-oxidation function
The preparation method of health food.
Background technology
Organism can generate active oxygen radical by the chemical reaction of single electron transfer, and Kinds of Free Radicals is various.Just
Often in the case of, these free radicals keep dynamic balance state, free radical constantly to generate in body, at the same also constantly by itself
System of defense is removed, and the health for largely accumulating and influencing human body is not will produce.The balance that active oxygen radical is generated and removed
When state is destroyed, content increases, and the abnormal state of oxidative stress occurs so as to cause body.Oxidative stress
(Oxidative Stress, OS) is that Soha professors propose on the basis of free radical in nineteen ninety.Be chronically at it is this not
Normal state can cause oxidativestress damage, free radical to attack body and generate series of chemical.A large amount of free radical heap
Product is also possible to that destruction can be generated to biofilm structure and function, to cause cancer, cardiovascular and cerebrovascular disease, body aging, nerve
The great chronic diseases such as degenerative disease, disease of immune system, diabetes, various inflammation.
As pressure is increasing in modern life and work, environmental pollution getting worse and the mankind use hand daily
Electromechanical brain etc. brings a large amount of radiation, increases so as to cause man-machine interior free yl, causes skin aging phenomenon, blood vessel occur old
Change, organ failure, gives rise to diseases.The health food with anti-oxidation function is thus developed to be of great significance.But it is existing
Have that the health food Varieties of known anti-oxidation function in technology are less and anti-oxidation function is not notable.Thus, at present
Need that a kind of oxidation resistance is more preferable, effect more fully product.
Invention content
The purpose of the present invention is to provide its of a kind of Chinese medicine composition with anti-oxidation function and health food preparations
Method can be used in treatment, alleviates and improve the middle-aged and the old because of a series of next damages of body oxidized zone and symptom.
In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：
The present invention provides a kind of Chinese medicine compositions with anti-oxidation function, include the raw material of following parts by weight：Gold and silver
Spend 3~45 parts, 1~9 part of purple perilla, 1~12 part of Rhizoma Chuanxiong, 1~21 part of the root bark of Chinese wolf-berry, 1~18 part of rhizoma cyperi.
Preferably, include the raw material of following parts by weight：4~15 parts of honeysuckle, 2~3 parts of purple perilla, 2~4 parts of Rhizoma Chuanxiong, bone
2~7 parts of skin, 2~6 parts of rhizoma cyperi.
The present invention provides the antioxidant functional foods of Chinese medicine composition described in said program.
Preferably, the dosage form of the health food is pulvis, granule or tablet.
The present invention provides the preparation methods of granule in health food described in said program, include the following steps：
1) honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with Extraction solvent and carries out soak extraction, filtered
To extracting solution, the Extraction solvent is water or ethanol water；
2) extracting solution obtained in the step 1) is concentrated, obtains medicinal extract；
3) medicinal extract obtained in the step 2) is mixed with auxiliary material and carries out wet granulation, obtain granule, the auxiliary material
For food auxiliary material.
Preferably, the gross mass of honeysuckle in the step 1), purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi and Extraction solvent
Volume ratio is 1g:(10~30) mL.
Preferably, the volumetric concentration of ethanol water is 30%~80% in the step 1).
Preferably, auxiliary material includes filler and corrigent in the step 3).
The present invention provides the preparation methods of pulvis in health food described in said program, include the following steps：
A honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with Extraction solvent) and carry out soak extraction, is obtained by filtration
Extracting solution, the Extraction solvent are water or ethanol water；
B) by the step A) in extracting solution centrifugation, take supernatant, obtain refined liquid；
C) to the step B) in refined liquid be spray-dried after, mixed with auxiliary material, obtain pulvis, the auxiliary material is
Food auxiliary material.
Preferably, the auxiliary material is xylitol and/or L-arabinose.
Beneficial effects of the present invention：Honeysuckle, purple perilla, river in the Chinese medicine composition with anti-oxidation function of the present invention
The components such as rhizome of chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are that can be used for the raw material of health food, wherein honeysuckle and purple perilla be both food and in
Medicinal material.The formula composition of the Chinese medicine composition of the present invention is theoretical according to traditional Chinese medicine anti-aging, further passes through modern pharmacology
Screening analysis, using honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry, rhizoma cyperi as primary raw material.In formula honeysuckle clear away heart-fire, the heat of lung,
The poison for solving skin is monarch drug in a prescription；Root bark of Chinese wolf-berry cool blood is except steaming, clearing lung-heat fall fire；Rhizoma cyperi soothing liver-qi stagnation, regulating the flow of QI to ease the stomach are ministerial drug altogether；Rhizoma Chuanxiong is lived
Blood gas, purple perilla regulating the flow of QI to ease the stomach are adjutant altogether.The effect of all medicines share plays heat-clearing, cool blood altogether, soothing the liver, qi-regulating, be suitable for the stagnation of the circulation of vital energy,
All cards on blood stasis, fire of deficiency type inflammation.The main component of the Chinese medicine composition of the present invention is Flavonoid substances, can be used for alleviating because in human body
The symptoms such as skin aging, blood vessel aging, organ failure caused by free radical increases.Meanwhile showing the present invention through toxicology test
The health food edible safety with anti-oxidation function being prepared, has no toxic side effect.
Description of the drawings
Influence of the sample to mouse weight in Fig. 1 embodiments 5；
Influence of the sample to MDA contents in serum in Fig. 2 embodiments 5；
Influence of the sample to Proteins in Serum carbonyl content in Fig. 3 embodiments 5；
Influence of the sample to SOD vigor in serum in Fig. 4 embodiments 5；
Influence of the sample to GSH contents in serum in Fig. 5 embodiments 5.
Specific implementation mode
The present invention provides a kind of Chinese medicine compositions with anti-oxidation function, include the raw material of following parts by weight：Gold and silver
Spend 3~45 parts, 1~9 part of purple perilla, 1~12 part of Rhizoma Chuanxiong, 1~21 part of the root bark of Chinese wolf-berry, 1~18 part of rhizoma cyperi.
In the present invention, the antioxidant composition includes 3~45 parts of honeysuckle, preferably 4~15 parts, more preferably 5
Part, the honeysuckle is from commercially available.Honeysuckle is the drying of caprifoliaceae plant honeysuckle (Lonicera japonica Thunb)
Bud or the flower just opened, property is sweet, trembles with fear, and return lung, the heart, stomach have clearing heat and detoxicating, dispelling wind and heat from the body effect.Mainly contain in honeysuckle
Have volatile oil, microelement kind, organic acid, triterpene saponin, flavonoids, etc. active ingredients, have it is antibacterial, antiviral,
It is anti-inflammatory it is antipyretic, to immune system, it is anti-oxidant the effects that, wherein total phenols and total flavonoid have antioxidation.Honeysuckle carries
Take liquid that can remove the H outside Mice Body2O2, can reduce be burned Murine Neutrophil synthesis ability, and reduce release it is molten
The ability of enzyme body enzyme, illustrates Flos Lonicerae extractive solution Wheat Protein.Also there are some researches prove honeysuckles can make T- in rat blood serum
AOC contents significantly increase, SOD activity significantly increases, GSH contents are significantly raised, and MDA contents occur significantly lowering phenomenon, so
Prove that it can improve the effect of internal oxidation resistance.
In the present invention, the antioxidant composition includes 1~9 part of purple perilla, preferably 2~3 parts, more preferably 2 parts, institute
Purple perilla is stated from commercially available.Purple perilla is the drying stem of labiate purple perilla (Perilla frutescens Britt), and property is pungent,
Temperature, return lung, the spleen channel have effects that regulating the flow of QI to ease the stomach, analgesic, tocolysis.Volatile oil, terpene, glycoside, phenolic acid are mainly contained in purple perilla
The active ingredients such as class, flavonoids, have antipyretic, antimicrobial, preventing or arresting vomiting, antitumor, hypoglycemic, reducing blood lipid, it is anti-oxidant, anti-inflammatory,
The effects that antiallergy.Extractive of perilla can promote ferric ion to be reduced into ferrous ion, and lecithin lipid oxidation is made to produce
The formation of object is suppressed.Extractive of perilla has remarkable effect to the Scavenging activity of free radical, has stronger oxidation resistance.
Its total flavonoid content is proportionate with free radical scavenging activity.
In the present invention, the antioxidant composition includes 1~12 part of Rhizoma Chuanxiong, preferably 2~4 parts, more preferably 2 parts,
The Rhizoma Chuanxiong is from commercially available.Rhizoma Chuanxiong is the dry root of samphire Rhizoma Chuanxiong (Ligusticum chuanxiong Hort)
Stem, property is acrid in flavour and warm in nature, Return liver, courage, pericardium channel, has blood-activating and qi-promoting, wind-expelling pain-stopping effect.Volatile oil, biology are mainly contained in Rhizoma Chuanxiong
The active ingredients such as alkali, phenolic acid and organic acid, have Green Tea Extract, to cardiovascular and cerebrovascular, Central nervous system, antalgic and sedative,
To digestive system, to respiratory system, to urinary system the effects that.Chuanxiong bioalkali can be by reducing NO, the third two in rat body
Aldehyde equal size has antioxidant activity to improve Activity of Superoxidase in Rats.It can also reduce in rat body
Nitric oxide synthase activity, to reduce the damage of rat nerve function and brain tissue.Ligustrazine has Function of Antioxygen Free Radical,
It can repair cerebral ischemia re-pouring injured.Flavonoids have the multiple biological activities such as anti-oxidant, anti-aging in Rhizoma Chuanxiong.It is purple
Flavones ingredient has the function of anti-aging, removing and inhibition free radical etc. in Soviet Union.
In the present invention, the antioxidant composition includes 1~21 part of the root bark of Chinese wolf-berry, preferably 2~7 parts, more preferably 3
Part, the root bark of Chinese wolf-berry is from commercially available.The root bark of Chinese wolf-berry is the dry root skin of matrimony vine of solanaceae plant (Lycium chinense Mill),
Property it is sweet, tremble with fear, return lung, liver and kidney channel, have cool blood except steam, clearing lung-heat fall fire effect.Flavonoids, alkaloid are mainly contained in the root bark of Chinese wolf-berry
The active ingredients such as class have the function of Adjust-blood lipid, blood pressure lowering, Green Tea Extract etc..Root bark of Chinese wolf-berry extracting solution can be by reducing in body
The generation of oxygen radical improves the ability for eliminating free radical, improves antioxidant ability of organism, root bark of Chinese wolf-berry extracting solution is to islet function
Destruction have therapeutic effect.
In the present invention, the antioxidant composition includes 1~18 part of rhizoma cyperi, preferably 2~6 parts, more preferably 2 parts,
The rhizoma cyperi is from commercially available.Rhizoma cyperi is the dry rhizome of sedge nutgrass flatsedge (Cyperus rotundus L), and property is pungent, micro-
Bitter, micro- sweet and neutral, Return liver, spleen, tri-jiao channel have soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving effect.It mainly contains and waves in rhizoma cyperi
The active ingredients such as hair oil class, flavonoids have calm, anti-inflammatory, the hypoglycemic, protection to nervous system, antiallergy, anti-oxidant etc.
Effect.Total flavonoid medical value is very high in rhizoma cyperi, has anticancer, antitumor, resisting cardiovascular disease, anti-inflammatory and antalgic, is immunized
The effects that adjusting, hypoglycemic, anti-oxidant, anti-aging and radioresistance.In addition, rhizoma cyperi flavones all has free radical and active oxygen ion
There is preferable Scavenging activity.The concentration of rhizoma cyperi flavones is higher, and free radical is eliminated more thorough.
The formula composition of antioxidant composition of the present invention is theoretical according to traditional Chinese medicine anti-aging, further passes through modern pharmacology
Screening analysis is learned, determining primary raw material is honeysuckle, Caulis Perillae, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry, rhizoma cyperi.In formula honeysuckle clear away heart-fire, lung
Heat, solve the poison of skin as monarch drug in a prescription；Root bark of Chinese wolf-berry cool blood is except steaming, clearing lung-heat fall fire；Rhizoma cyperi soothing liver-qi stagnation, regulating the flow of QI to ease the stomach are ministerial drug altogether；
Rhizoma Chuanxiong blood-activating and qi-promoting, Caulis Perillae regulating the flow of QI to ease the stomach are adjutant altogether.The effect of all medicines share plays heat-clearing, cool blood altogether, soothing the liver, qi-regulating, fits
All cards in the stagnation of the circulation of vital energy, blood stasis, fire of deficiency type inflammation.The antioxidant composition main component of the present invention is flavonoids, can be alleviated because of human body
The symptoms such as skin aging, blood vessel aging, organ failure caused by interior free radical increases.
The present invention provides a kind of antioxidant functional foods including Chinese medicine composition described in said program；It is described anti-oxidant
The content of total flavonoids in health food is preferred >=97.60mg/g；The antioxidant functional food further includes preferably auxiliary material；Institute
It is food auxiliary material to state auxiliary material.
In the present invention, the auxiliary material preferably include filler and corrigent, more preferably further include wetting agent and/or
Adhesive；The filler is preferably starch, dextrin, pregelatinized starch, lactose, microcrystalline cellulose, sucrose, mannitol, sorb
It is one or more in alcohol and inorganic salts, more preferably dextrin and/or lactose；The corrigent is preferably sweetener, fragrance
With one or more in essence, more preferably sweetener；The sweetener is preferably honey element and/or xylitol, more preferably
For honey element；The wetting agent is preferably distilled water or ethanol water, and the ethyl alcohol that more preferably volume fraction is 50% is water-soluble
Liquid；Described adhesive is preferably starch slurry, the derivative of cellulose, polyvinylpyrrolidone, carboxymethylcellulose sodium solution, bright
Starch slurries one or more in glue and sucrose, that more preferably volume fraction is 10%.
In the present invention, the dosage form of the antioxidant functional food is custard agent, decoction, pulvis, granule or tablet, preferably
Pulvis, granule or tablet；The tablet is preferably chewable tablets.
In the present invention, when the dosage form of the antioxidant functional food is granule, the mass ratio of the medicinal extract and auxiliary material
Preferably:(9~10):(10~11), preferably 99：101；The auxiliary material is preferably dextrin, lactose, honey element and volume fraction
For 10% starch slurry；The parts by weight for the starch slurry that the medicinal extract, dextrin, lactose, honey element and volume fraction are 10% are preferred
It is 49.5 parts, 16.5 parts, 33 parts, 1 part and 10 parts.
The present invention provides the preparation methods of granule health food described in said program, include the following steps：
1) honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with Extraction solvent and carries out soak extraction, filtered
To extracting solution, the Extraction solvent is water or ethanol water；
2) extracting solution obtained in the step 1) is concentrated, obtains medicinal extract；
3) medicinal extract obtained in the step 2) is mixed with auxiliary material and carries out wet granulation, obtain granule.
In the present invention, honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed into progress with water or ethanol water
Extracting solution is obtained by filtration in soak extraction；The honeysuckle, purple perilla, Rhizoma Chuanxiong, the gross mass of the root bark of Chinese wolf-berry and rhizoma cyperi and Extraction solvent
Volume ratio is 1g:(10~30) mL, preferably 1g:(15~25) mL, more preferably 1g:18mL；The body of the ethanol water
Product a concentration of 30%~80%, preferably 40%~75%, more preferably 70%.In the present invention, the temperature of the extraction is preferred
It is 80~100 DEG C, more preferably 100 DEG C；The number of the extraction is preferably 1~3 time, more preferably 2 times；The extraction when
Between preferably 90~240min, more preferably 210min；The mode of the filtering is preferably plate compression.
The present invention centrifuges extracting solution, takes supernatant, obtain refined liquid after obtaining extracting solution；The centrifugation
Equipment is preferably ultracentrifuge；The time of the centrifugation is preferably 20~40min, more preferably 30min；The centrifugation turns
Speed is preferably 7000~8000r/min, more preferably 7500 r/min.
The present invention concentrates refined liquid, obtains medicinal extract after obtaining refined liquid；The mode of the concentration preferably subtracts
Pressure concentration；The pressure of the reduced pressure is preferably -80kPa~-40kPa, more preferably -60kPa；It is described to be concentrated under reduced pressure
To the relative density of medicinal extract be preferably 1.1~1.3, more preferably 1.2.
The present invention mixes with auxiliary material after obtaining medicinal extract, by medicinal extract and carries out wet granulation, obtains granule；The wet method system
The method of grain preferably mixes the medicinal extract with auxiliary material, dry, pulverize successively through first, the first sieving, softwood processed, granulation,
Second drying, the second sieving, obtain granule.In the present invention, the mode of first drying is preferably dried in vacuo；Described
The temperature of one drying is preferably 60~90 DEG C, more preferably 80 DEG C；The time of first drying is preferably 1~3h, more preferably
For 2h；The mode of the crushing is preferably ground；The granularity of first sieving is preferably 90~110 mesh, more preferably
100 mesh；It is 10% starch slurry as adhesive that volumetric concentration is preferably used when the softwood processed；The granulation is preferably using crowded
Platen press crosses the sieve granulation of 14 mesh；The mode of second drying is preferably fluidized bed drying；It is described second drying temperature be preferably
60~90 DEG C, more preferably 80 DEG C；The time of second drying is preferably 10~60min, more preferably 30min；Described
The granularity of two sievings is preferably 14~18 mesh, more preferably 16 mesh.
Granule prepared by the present invention is good in taste, and epigranular, color and luster is consistent, no moisture absorption, softening, caking, deliquescence etc.
Phenomenon.
In the present invention, when the health food is granule, the dose of the Chinese medicine composition is preferably 3~9g/
It, more preferably 6g/ days.
The present invention provides the preparation methods of the tablet of the health food described in said program, include the following steps：
A) honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with water or ethanol water and carry out soak extraction,
Extracting solution is obtained by filtration；
B) extracting solution obtained in the step a) is concentrated, obtains medicinal extract；
C) medicinal extract obtained in the step b) is mixed with auxiliary material and carries out wet granulation, the granulation that will be obtained obtains
To tablet；The auxiliary material is with above-mentioned granule auxiliary material, and details are not described herein again.
In the present invention, honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed into progress with water or ethanol water
Extracting solution is obtained by filtration in refluxing extraction；The honeysuckle, purple perilla, Rhizoma Chuanxiong, the gross mass of the root bark of Chinese wolf-berry and rhizoma cyperi and Extraction solvent
Volume ratio is 1g:(10~30) mL, preferably 1g:(15~25) mL, more preferably 1g:16mL；The body of the ethanol water
Product a concentration of 30%~80%, preferably 40%~75%, more preferably 70%.In the present invention, the temperature of the extraction is preferred
It is 80~100 DEG C, more preferably 85~95 DEG C, most preferably 90 DEG C；The number of the extraction is preferably 1~3 time, more preferably
2 times；The time of the extraction is preferably 90~240min, more preferably 150min；The mode of the filtering is preferably sheet frame pressure
Filter.
The present invention concentrates extracting solution, obtains medicinal extract after obtaining extracting solution；The mode of the concentration preferably subtracts
Pressure concentration；The pressure of the reduced pressure is preferably -80kPa~-40kPa, more preferably -60kPa；It is described to be concentrated under reduced pressure
To the relative density of medicinal extract be preferably 1.1~1.3, more preferably 1.15.
The present invention is after obtaining medicinal extract, after obtaining medicinal extract, auxiliary material and medicinal extract is mixed, wet granulation, that will be obtained
Grain tabletting, obtains chewable tablets.In the present invention, the method for the wet granulation with it is above-mentioned prepare granule health food when side
Method, details are not described herein again.
In the present invention, when the dosage form of the health food is tablet, the dose of the tablet is preferably 4~12g/
It, more preferably 8g/ days.
The present invention provides the preparation methods of the pulvis of the health food described in said program, include the following steps：
A honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with water or ethanol water) and carry out soak extraction, mistake
Filter obtains extracting solution；
B) by the step A) in extracting solution centrifugation, take supernatant, obtain refined liquid；
C) to the step B) in refined liquid be spray-dried after, mixed with auxiliary material, obtain pulvis；The auxiliary material is
Food auxiliary material, preferably xylitol and/or L-arabinose, more preferably xylitol.
In the present invention, honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with water or ethanol water and is soaked
Bubble extraction, is obtained by filtration extracting solution；The quality of the honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi and water or ethanol water
Volume ratio is 1g:(10~30) mL, preferably 1g:(15~25) mL, more preferably 1g:16mL；The body of the ethanol water
Product a concentration of 30%~80%, preferably 40%~75%, more preferably 70%.In the present invention, the temperature of the extraction is preferred
It is 80~100 DEG C, more preferably 85~95 DEG C, most preferably 90 DEG C；The number of the extraction is preferably 1~3 time, more preferably
2 times；The time of the extraction is preferably 50~120min, more preferably 60~90min；The mode of the filtering is preferably sheet frame
Press filtration.
The present invention centrifuges extracting solution, takes supernatant, obtain refined liquid after obtaining extracting solution；The centrifugation
Equipment is preferably ultracentrifuge；The time of the centrifugation is preferably 20~40min, more preferably 30min；The centrifugation turns
Speed is preferably 8000~12000r/min, more preferably 10000 r/min.
The present invention is spray-dried refined liquid to obtain dry product, dry product and auxiliary material is mixed after obtaining refined liquid
It closes, obtains pulvis；The temperature of the spray drying is preferably 100~140 DEG C, more preferably 120 DEG C；The dry product with it is auxiliary
The mass ratio of material is preferably 100:7.
In the present invention, when the dosage form of the health food is pulvis, the dose of the pulvis is preferably 2~6g/
It, more preferably 4g/ days.
With reference to embodiment to a kind of Chinese medicine composition and its health care food with anti-oxidation function provided by the invention
The preparation method of product is described in detail, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
Honeysuckle 3kg, purple perilla 3kg, Rhizoma Chuanxiong 3kg, root bark of Chinese wolf-berry 7kg, rhizoma cyperi 6kg are weighed, 330L water boiling and extractions are added
120min, filtering, filter residue is mixed with 330L water, decocts 90min again.Merge filtrate twice, obtains extracting solution.Extracting solution is adopted
30min is centrifuged with the rotating speed of 7500r/min with ultracentrifuge.Supernatant is concentrated under reduced pressure under the pressure of -60kPa, is obtained
The medicinal extract that relative density is 1.2.
Medicinal extract is mixed with 4.4kg dextrin, the first drying is carried out at 90 DEG C.Crushing sieves with 100 mesh sieve, and is with volumetric concentration
10% starch slurry is as adhesive, and by screenings softwood, extrusion crosses the sieve granulation of 14 mesh, and the second drying is carried out at 80 DEG C
16 mesh sieves are crossed afterwards, obtain composition granule.
Embodiment 2
Honeysuckle 45kg, purple perilla 1kg, Rhizoma Chuanxiong 1kg, root bark of Chinese wolf-berry 1kg, rhizoma cyperi 1kg are weighed, is with 245L volumetric concentrations
Filter residue and 245L volumetric concentrations are 70% by 70% ethanol water mixing, the refluxing extraction 60min at 85 DEG C, filtering
Ethanol water mixes, the refluxing extraction 120min again at 80 DEG C.Merge filtrate twice, obtains extracting solution.By extracting solution-
It is concentrated under reduced pressure under the pressure of 40kPa, obtains the medicinal extract that relative density is 1.15.By medicinal extract and dextrin 6kg, lactose 3kg, sweetness
0.2kg elements mix, and the first drying is carried out at 90 DEG C.Crushing sieves with 100 mesh sieve, the ethanol water for being 50% with volumetric concentration
As wetting agent, by screenings softwood, extrusion crosses the sieve granulation of 14 mesh, and it is whole that 16 mesh sieve is crossed after progress second is dried at 60 DEG C
Grain, tabletting obtain tablet.
Embodiment 3
Honeysuckle 50kg, purple perilla 20kg, Rhizoma Chuanxiong 10kg are weighed, root bark of Chinese wolf-berry 30kg, rhizoma cyperi 20kg add water 1300L, decoction to carry
90min is taken, is filtered, by filter residue plus water 1040L, decocts extraction 60min.Merge filtrate twice, obtains extracting solution.Extracting solution is used
Ultracentrifuge centrifuges 30min with the rotating speed of 10000r/min.Collection supernatant is refined liquid.Refined liquid is sprayed at 120 DEG C
The xylitol of dried object weight 7% is added after mist drying, obtains pulvis.
The indices of granule of the embodiment 4 to being prepared in embodiment 1 are measured
It presses《Chinese Pharmacopoeia》Related request is measured, and is surveyed to the mobility, size distribution, water content of granule
It is fixed.The indices measurement result of granule of the present invention is shown in Table 1；The quality examination of granule of the present invention the results are shown in Table 2.
1 granule indices measurement result of table
As shown in Table 2, the quality for the granule that embodiment 1 is prepared meets《Chinese Pharmacopoeia》It is required that.
The anti-oxidation function of the granule of 5 embodiment 1 of embodiment is studied
Weight range is chosen in the male mouse of kunming 80 of 18~22g, is provided by Yanbian University's Experimental Animal Center.It is real
By animal subject adaptable fed one week before testing, progress next step experiment after sign performance is good.
Establish D- galactose oxidases damage mouse model：To 80 120 mg/kg BW shapes of mouse peritoneal injection of d-galactose
At model of oxidative, one time a day, injection volume 0.01mL/g, the variation of observation mouse hair color, activity characters, continued administration 6
Week.Modeling principle：Long-term a large amount of injection of d-galactose can generate excessive reactive oxygen species and free radicals content and increase, big to generate
Oxidation product is measured, leads to the reduction of body inner cell organ choush function, to generate various diseases.
Mouse after modeling is grouped at random, is divided into 3 study dosage groups and 1 model control group is taken with the day for human beings
Dosage is foundation, and 3 low dose group, middle dose group and high dose group study dosage group gavages give the embodiment 1 of various concentration
The granule being prepared, dosage are respectively 0.24g/kg BW, 0.48g/kg BW, 0.96g/kg BW, administration number of times 1
Times/day, it is respectively equivalent to 5,10,20 times of amounts of human body taking dose；Model control group gavage same volume distilled water.In gavage
While administration, continue to mouse peritoneal injection of d-galactose.Animal is put to death after experiment, eyeball takes blood.After weighing administration
0d, 10d, 20d, 30d mouse weight, and measure MDA contents, SOD vigor, content of protein carbonyl group and GSH contents.
(1) influence of the sample to mouse weight the results are shown in Table 3, Fig. 1.As a result it shows：0~30d mouse weights are administered to continue
Increase, each administration group compared with model control group, administration 0,10,20, there was no significant difference for the weight of 30d, show test sample
Product are on mouse weight without influence.
Influence of 3 granule of table to mouse weight
(LG:Low dose group；MG：Middle dose group；HG：High dose group；MC：Model control group)
(2) influence of the sample to MDA contents in serum the results are shown in Table 4, Fig. 2, as a result show：Compared with MC groups, LG, MG,
The MDA contents of tri- groups of HG decrease, and have significant difference (p<0.05), illustrate that the given the test agent can be in mouse
Conspicuousness reduces internal MDA contents after oxidative damage, reduces peroxide injury.This reduces lipid mistake the result shows that the drug has
The effect of oxidation, the experiment item index result are positive.
4 MDA assay results of table
Note：* each administration group and the more significant difference of model control group, p<0.05, following table is same
(3) influence of the sample to Proteins in Serum carbonyl content the results are shown in Table 5, Fig. 3, as a result show：Compared with MC groups,
The content of protein carbonyl group that tri- groups of LG, MG, HG is substantially reduced, and significant difference (p<0.05), illustrate that embodiment 1 is made
Standby obtained granule has the ability for the oxidative damage for repairing protein.Illustrate that this index experimental result is positive.
5 content of protein carbonyl group measurement result of table
(4) influence of the sample to SOD vigor in serum the results are shown in Table 6, Fig. 4, as a result show：Compared with MC groups, LG, MG,
The SOD vigor of tri- groups of HG has raised trend, measurement result to have significant (p<0.05).With the increase of dosage,
The raised amplitude of SOD vigor increases, and illustrates that the given the test agent can improve antioxidase activity, and the experiment item index result is in sun
Property.
6 SOD vitality tests result (x ± s, n=10) of table
(5) influence of the sample to GSH contents in serum the results are shown in Table 7, Fig. 5, as a result show：LG, MG, HG and MC group ratio
Compared with the display of GSH contents reduces, the significant meaning (p< of measurement result;0.05).With the increase of dosage, tri- groups of LM, MG, HG's
GSH changes of contents is notable.Show to give the mouse of granule through gavage, internal GSH contents have compared with model control group
It significantly increases, wherein high dose group increases most notable.Show that the given the test agent plays the role of increasing antioxidant, the experiment item
Index result is negative.
7 GSH assay results of table
As shown in the above, MDA contents, SOD vigor, content of protein carbonyl group and GSH content four indices knot
Fruit shows the positive, can determine that the anti-oxidant results of animal of granule that embodiment 1 is prepared is positive.
As seen from the above embodiment, the present invention provides a kind of Chinese medicine compositions with anti-oxidation function and its health care to eat
The granule of the preparation method of product, the health food has reduction content of protein carbonyl group and MDA contents, increases anti-SOD vigor
With the effect of GSH contents, as a result show that the health food contributes to mouse to repair the peroxide injury caused by D- galactolipins.According to
Function of health food evaluates criterion, can assert that the Chinese medicine composition and its health food have anti-oxidation function.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition with anti-oxidation function, includes the raw material of following parts by weight：3~45 parts of honeysuckle, purple perilla 1
~9 parts, 1~12 part of Rhizoma Chuanxiong, 1~21 part of the root bark of Chinese wolf-berry, 1~18 part of rhizoma cyperi.
2. Chinese medicine composition according to claim 1, which is characterized in that include the raw material of following parts by weight：Honeysuckle 4~
15 parts, 2~3 parts of purple perilla, 2~4 parts of Rhizoma Chuanxiong, 2~7 parts of the root bark of Chinese wolf-berry, 2~6 parts of rhizoma cyperi.
3. a kind of antioxidant functional food including Chinese medicine composition described in claims 1 or 2.
4. antioxidant functional food according to claim 3, which is characterized in that the dosage form of the health food be pulvis,
Granule or tablet.
5. the preparation method of granule, includes the following steps in health food described in claim 4：
1) honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with Extraction solvent and carries out soak extraction, be obtained by filtration and carry
It is water or ethanol water to take liquid, the Extraction solvent；
2) extracting solution obtained in the step 1) is concentrated, obtains medicinal extract；
3) medicinal extract obtained in the step 2) is mixed with auxiliary material and carries out wet granulation, obtain granule, the auxiliary material is food
Product auxiliary material.
6. the preparation method of granule according to claim 5, which is characterized in that honeysuckle, purple perilla, river in the step 1)
Rhizome of chuanxiong, the root bark of Chinese wolf-berry and the gross mass of rhizoma cyperi and the volume ratio of Extraction solvent are 1g:(10~30) mL.
7. according to the preparation method of the granule of claim 5 or 6, which is characterized in that ethanol water in the step 1)
Volumetric concentration be 30%~80%.
8. the preparation method of granule according to claim 5, which is characterized in that auxiliary material includes filler in the step 3)
And corrigent.
9. the preparation method of pulvis, includes the following steps in health food described in claim 4：
A honeysuckle, purple perilla, Rhizoma Chuanxiong, the root bark of Chinese wolf-berry and rhizoma cyperi are mixed with Extraction solvent) and carry out soak extraction, extraction is obtained by filtration
Liquid, the Extraction solvent are water or ethanol water；
B) by the step A) in extracting solution centrifugation, take supernatant, obtain refined liquid；
C) to the step B) in refined liquid be spray-dried after, mixed with auxiliary material, obtain pulvis, the auxiliary material is food
Auxiliary material.
10. the preparation method of pulvis according to claim 9, it is characterised in that：The auxiliary material be xylitol and/or L- I
Uncle's sugar.
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