CN109464609A - Composition and preparation method thereof with effect for reducing blood fat - Google Patents
Composition and preparation method thereof with effect for reducing blood fat Download PDFInfo
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- CN109464609A CN109464609A CN201811384538.1A CN201811384538A CN109464609A CN 109464609 A CN109464609 A CN 109464609A CN 201811384538 A CN201811384538 A CN 201811384538A CN 109464609 A CN109464609 A CN 109464609A
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- hawthorn
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- blood fat
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of composition and preparation method thereof with effect for reducing blood fat, the composition are prepared by following raw material in parts by weight: 0.1-10 parts of golden camellia tea, 0.1-10 parts of hawthorn, 0.1-10 parts of leaves of Hawthorn, 0.1-10 parts of Siraitia grosvenorii, 0.1-10 parts of cortex cinnamomi, 0.1-10 parts of loguat leaf, 0.1-10 parts of sugarcane top and 0.1-10 parts of lophatherum gracile.The present invention perfectly blends together the fragrance of the sweet tea of Siraitia grosvenorii, the acid of hawthorn, leaves of Hawthorn, loguat leaf and the puckery and bitter of golden camellia tea, sugarcane top, the sweet taste of lophatherum gracile and cortex cinnamomi, gained tea product good mouthfeel, with anti-oxidant, auxiliary adjustment of blood fat, blood glucose, promote functions of intestines and stomach, relieving sore-throat, anti-inflammatory and other effects and without side-effects.
Description
Technical field
The present invention relates to health tea technical field, specifically a kind of composition and its preparation side with effect for reducing blood fat
Method.
Background technique
With economic and industry high speed development, the continuous improvement of the goods and materials living standard of people, overnutrition at
For a big health problem of modern society, the problems such as hyperlipidemia, hyperglycemia, gastro-intestinal problems, laryngopharyngitis, annoyings many people.City
Though there are many reducing blood lipid, drug that is hypoglycemic, promoting the functions such as stomach, relieving sore-throat, anti-inflammatory on face, side effect is bigger.
Using natural health-care products or other dietotherapies, larger side effect caused by taking drugs not only is avoided, but also maintain people
The health of body becomes the only choosing that people chase health.Therefore, it develops and studies a kind of composition with effect for reducing blood fat
It is very necessary, the development trend of society was not only complied with, but also meet the market demand.
Many health products are mixed by various traditional Chinese medicine ingredients on the market, and mouthfeel is very poor, and healthcare function compared with
It to be single, and is not easy to absorb, while larger to taste injury, is not suitable for long-term drinking.
Summary of the invention
The present invention market Antilipemic health-care tea there are aiming at the problem that, a kind of good mouthfeel is provided, absorption of human body is conducive to,
With auxiliary adjustment of blood fat, blood glucose, promote functions and the composition without side-effects such as functions of intestines and stomach, relieving sore-throat, anti-inflammatory.
In order to achieve the goal above, The technical solution adopted by the invention is as follows:
A kind of composition with effect for reducing blood fat, the composition are prepared by following raw material in parts by weight: Camellia nitidissima
0.1-10 parts of leaf, 0.1-10 parts of hawthorn, 0.1-10 parts of leaves of Hawthorn, 0.1-10 parts of Siraitia grosvenorii, 0.1-10 parts of cortex cinnamomi, loguat leaf 0.1-
10 parts, 0.1-10 parts of sugarcane top and 0.1-10 parts of lophatherum gracile.
The drug effect of this programme each component is as follows:
Golden camellia tea: golden camellia tea is Theaceae (Theaceae) Camellia (Camellia) Camellia nitidissima group (Sect.
Chrysantha Chang) dried leaf of plant also contains containing a variety of physiologically active ingredients such as tea polyphenols, tea saponin, flavonoids
There are a variety of pairs of human bodies such as more organic germanium, selenium and zinc to have the microelement of important health-care effect, while it or Zhuang are civil
A kind of Chinese traditional herbs, have hypoglycemic, reducing blood lipid, drop cholesterol in serum, inhibit tumour growth, improve immunity of organism energy
The different physiological roles such as power, without other toxic side effects.
Hawthorn: hawthorn is the dry fruit of hawthorn (Crataegus L.) or Malus (Malus Mill.) plant, can
It is used as medicine, is the distinctive dual-purpose of drug and fruit tree species of China, there is food digesting stomach fortifying, scattered stasis, change the effect of turbid lipid-loweringing, can be used for meat
It stagnates, gastral cavilty turgor, let out dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, chest impediment and cardialgia, hernia pain, hyperlipidemia,
Without other toxic side effects.
Leaves of Hawthorn: leaves of Hawthorn is the dried leaf of hawthorn (Crataegus L.) or Malus (Malus Mill.) plant,
It is sour, it is mild-natured, have the medicinal history of nearly one thousand years in China as traditional Chinese medicine, there is activating microcirculation and removing stasis medicinal, qi-regulating to promote blood circulation, change it is turbid
The effect of lipid-loweringing, is used for qi depression to blood stasis, chest impediment and cardialgia, chest distress, palpitation and amnesia, dizziness and tinnitus, hyperlipidemia, without other poison
Side effect.
Siraitia grosvenorii: Siraitia grosvenorii is the dry fruit of cucurbitaceous plant Siraitia grosvenorii (Siraitia grosvenorii).Alias
Sweating fruit, balloonvine heartseed herb, Semen Momordicae, invaluable, arhat table, naked tortoise bar are described as " angle fruit " by people, are national first batch of approvals
One of dual-purpose of drug and food material, have effects that sound, laxation defaecation are opened in clearing heat and moistening lung, relieving sore-throat, lost for lung-heat type cough, pharyngalgia
Sound, dry constipation of intestines, without other toxic side effects.
Cortex cinnamomi: cortex cinnamomi is the dry bark of Lauraceae (Lauraceae) Cinnamomum (Cinnamomum) plant.Nature and flavor are pungent, sweet, greatly
Heat；Return kidney, spleen, the heart, Liver Channel.Have the effects that anti-oxidant, anti-inflammatory, immunological regulation, adjust glycolipid metabolism, also commonly uses and make fragrance,
Without other toxic side effects.
Loguat leaf: loguat leaf is the leaf of rosaceae (Rosaceae) loquat category (Eriobotrya) plant.There is clearing lung-heat to stop
Cough, stomach function regulating diuresis, the effect of quenching the thirst.There are treatment lung feverish cough, hemoptysis, bleeding from five sense organs or subcutaneous tissue, stomach hot vomiting effect, without other toxic side effects.
Sugarcane top: sugarcane top is the drying blade of grass family (Gramineae) saccharum (Saccharum) plant.Have
The effects of anti-oxidant, hypoglycemic, anti-inflammatory, without other toxic side effects.
Lophatherum gracile: lophatherum gracile is the drying blade of grass family (Gramineae) lophatherum gracile category (Lophatherum) plant.
With refrigerant, antipyretic, diuresis and the effect of hasten parturition, without other toxic side effects.
Preferably, the composition with effect for reducing blood fat, is prepared by following raw material in parts by weight: Camellia nitidissima
5 parts of leaf, 10 parts of hawthorn, 5 parts of leaves of Hawthorn, 10 parts of Siraitia grosvenorii, 1 part of cortex cinnamomi, 1 part of loguat leaf, 1 part of sugarcane top and 1 part of lophatherum gracile.
Preferably, the composition with effect for reducing blood fat, is prepared by following raw material in parts by weight: Camellia nitidissima
3 parts of leaf, 8 parts of hawthorn, 2 parts of leaves of Hawthorn, 6 parts of Siraitia grosvenorii, 0.5 part of cortex cinnamomi, 0.5 part of loguat leaf, 0.5 part of sugarcane top and lophatherum gracile
0.5 part.
Preferably, the composition with effect for reducing blood fat, is prepared by following raw material in parts by weight: Camellia nitidissima
2 parts of leaf, 6 parts of hawthorn, 3 parts of leaves of Hawthorn, 4 parts of Siraitia grosvenorii, 0.1 part of cortex cinnamomi, 0.1 part of loguat leaf, 0.1 part of sugarcane top and lophatherum gracile
0.1 part.
Preparation method of composition of the present invention with effect for reducing blood fat includes the following steps: first to select and clean gold
Jasmine tea leaf, hawthorn, leaves of Hawthorn, Siraitia grosvenorii, cortex cinnamomi, loguat leaf, sugarcane top, lophatherum gracile weigh respectively after dry according to aforementioned proportion
Raw material pulverizes and sieves, and is uniformly mixed, and packs to get the composition with effect for reducing blood fat.
Preferably, the method for the drying be shady place dry, dried under the sun, be placed in 20-80 DEG C of baking oven it is dry and
It is placed in one of freeze-drying in freeze drier.
Preferably, it will pulverize and sieve and be uniformly mixed after obtained composition conventionally extracts, obtained extract
Passing through polishing purification, blood fat reducing preparation is prepared according to the common process of preparation.
Preferably, the conventional method is extracted including one in decoction, diacolation, dipping, ultrasound, reflux and steam distillation
Kind method.
Preferably, the method for the polishing purification includes water extract-alcohol precipitation, extraction, silica gel column chromatography separation, macroporous resin column
One of separation and ion exchange post separation.
Preferably, the preparation includes powder, tablet, capsule, granule, oral solution or pill.
Compared with prior art, it advantages of the present invention and has the beneficial effect that
The present invention is based on Chinese medicine traditional medicine theory and modern traditional Chinese and western medicine theories, by scientific matching, by the sweet tea of Siraitia grosvenorii, hawthorn
Acid, leaves of Hawthorn, loguat leaf and the puckery and bitter of golden camellia tea, sugarcane top, the fragrance of the sweet taste of lophatherum gracile and cortex cinnamomi it is perfect
It blends together, gained tea product good mouthfeel has anti-oxidant, auxiliary adjustment of blood fat, blood glucose, promotes functions of intestines and stomach, relieving sore-throat, resists
Inflammation and other effects and without side-effects, long-term drinking is conducive to human health, and raw material materials are convenient, and manufacture craft is simple, is suitble to
Batch making.
Detailed description of the invention
Fig. 1: groups of animals blood lipid level is tested in product of the present invention reducing blood lipid；
Fig. 2: product of the present invention is to H2O2The influence of PC-12 the cell LDH and SOD of damage.
Specific embodiment
Invention is further described in detail With reference to embodiment.It is emphasized that following the description is only
It is merely exemplary, the range and its application being not intended to be limiting of the invention.
Embodiment 1
A kind of composition with effect for reducing blood fat, is prepared by following raw material in parts by weight: 5 parts of golden camellia tea, hawthorn
10 parts, 5 parts of leaves of Hawthorn, 10 parts of Siraitia grosvenorii, 1 part of cortex cinnamomi, 1 part of loguat leaf, 1 part of sugarcane top and 1 part of lophatherum gracile.
Preparation method are as follows: first select and clean golden camellia tea, hawthorn, leaves of Hawthorn, Siraitia grosvenorii, cortex cinnamomi, loguat leaf, sugarcane
Leaf, lophatherum gracile, shady place according to aforementioned proportion weigh each raw material after drying, pulverize and sieve, and are uniformly mixed, and pack to get having
The composition of effect for reducing blood fat.
Embodiment 2
A kind of composition with effect for reducing blood fat, is prepared by following raw material in parts by weight: 3 parts of golden camellia tea, hawthorn 8
Part, 2 parts of leaves of Hawthorn, 6 parts of Siraitia grosvenorii, 0.5 part of cortex cinnamomi, 0.5 part of loguat leaf, 0.5 part of sugarcane top and 0.5 part of lophatherum gracile.
Preparation method are as follows: first select and clean golden camellia tea, hawthorn, leaves of Hawthorn, Siraitia grosvenorii, cortex cinnamomi, loguat leaf, sugarcane
Leaf, lophatherum gracile weigh each raw material according to aforementioned proportion after drying under the sun, pulverize and sieve, and are uniformly mixed, and pack to get tool
There is the composition of effect for reducing blood fat.
Embodiment 3
A kind of composition with effect for reducing blood fat, is prepared by following raw material in parts by weight: 2 parts of golden camellia tea, hawthorn 6
Part, 3 parts of leaves of Hawthorn, 4 parts of Siraitia grosvenorii, 0.1 part of cortex cinnamomi, 0.1 part of loguat leaf, 0.1 part of sugarcane top and 0.1 part of lophatherum gracile.
Preparation method are as follows: first select and clean golden camellia tea, hawthorn, leaves of Hawthorn, Siraitia grosvenorii, cortex cinnamomi, loguat leaf, sugarcane
Leaf, lophatherum gracile are placed under 40-60 DEG C of baking oven and weigh each raw material according to aforementioned proportion after drying, pulverize and sieve, be uniformly mixed, packet
Dress is to get the composition with effect for reducing blood fat.
Embodiment 4
A kind of composition with effect for reducing blood fat, is prepared by following raw material in parts by weight: 5 parts of golden camellia tea, hawthorn 3
Part, 4 parts of leaves of Hawthorn, 2 parts of Siraitia grosvenorii, 2 parts of cortex cinnamomi, 6 parts of loguat leaf, 1 part of sugarcane top and 2 parts of lophatherum gracile.
Preparation method are as follows: first select and clean golden camellia tea, hawthorn, leaves of Hawthorn, Siraitia grosvenorii, cortex cinnamomi, loguat leaf, sugarcane
Leaf, lophatherum gracile are placed in freeze drier after being lyophilized and weigh each raw material according to aforementioned proportion, pulverize and sieve, be uniformly mixed, packet
Dress is to get the composition with effect for reducing blood fat.
Safety evaluatio
Experimental material: 1,2,3,4 gained health protection tea of Example respectively adds 10 times of water to decoct 3 times, 30 minutes every time, merges and decoct
The water extract to get 1,2,3,4 product of embodiment is concentrated in boil liquid.
Acute toxicity test in mice: experiments have shown that, it is administered with intragastric administration on mice, can not accurately measure the production of embodiment 1,2,3,4
The LD of product50。
Rat acute toxicity test: with the water extract of 1,2,3,4 product of embodiment to rat oral gavage 7 days, the rat of administration
Maximum dosage is 20g/kgBW, actually belongs to nontoxic grade.
Rat chronic toxicity test: with water extract stomach-filling 3 months of 1,2,3,4 product of embodiment, every biochemical indicator was aobvious
Show, animal organ's dissection, compared with the control group, without overt toxicity effect.
Lipid-loweringing experiment
Experimental material: the golden camellia tea of 10g, the hawthorn of 40g, the leaves of Hawthorn of 10g, the Siraitia grosvenorii of 20g, the cortex cinnamomi of 1g, 1g Pi are taken
Rake leaf, 1g sugarcane top, 1g lophatherum gracile, are pulverized and mixed, and add 10 times of water to decoct 3 times, 30 minutes every time, merge decoction liquor, be concentrated, i.e.,
Obtain reducing blood lipid extract.
Experimental method: 60 SPF grades of KM mouse are used into basal feed adaptable fed one week in laboratory environments, then
6 groups are randomly divided into, every group of 10 animals.Respectively A: blank control group, B: model control group, C: Simvastatin suspension is given
3mg/kg stomach-filling, D: colestid piece suspension 3mg/kg stomach-filling, E are given: give reducing blood lipid solution of extract 1g/kg stomach-filling,
F: reducing blood lipid solution of extract 2g/kg stomach-filling is given.In addition to blank control group, experimental group injects 75% yolk emulsion
0.2mL/10g, establishes acute hyperlipidemia model, and A, B group give the distilled water of same volume.Groups of animals anaesthetizes posterior orbit after 3 weeks
Blood is taken, centrifugation obtains serum, and measurement total cholesterol (T-CHO), high-density protein (HDLC) are horizontal, lipid-loweringing test result such as attached drawing
Shown in 1.
From attached drawing 1 as can be seen that the experimental results showed that, compared with blank group, model group rats T-CHO is significantly raised,
HDLC is substantially reduced, and illustrates modeling success.After three weeks, C, D, E, F group rat T-CHO are substantially reduced, and HDLC is obvious for administration
It increases, wherein two groups of drugs of C, D are commercially available fat-reducing medicament, and two groups of E, F are product of the present invention, and it is obvious to illustrate that product of the present invention has
Effect for reducing blood fat be better than market product.
Oxidation Resistance Test
Experimental material: the golden camellia tea of 10g, the hawthorn of 40g, the leaves of Hawthorn of 10g, the Siraitia grosvenorii of 20g, the cortex cinnamomi of 1g, 1g Pi are taken
Rake leaf, 1g sugarcane top, 1g lophatherum gracile, are pulverized and mixed, and add 10 times of water to decoct 3 times, 30 minutes every time, merge decoction liquor, be concentrated, i.e.,
Obtain reducing blood lipid water extract of the present invention.
Experimental method: Trypsin digestion is in the PC-12 cell of logarithmic growth phase, and gently piping and druming mixes, and is made unicellular
Suspension, cell count, about 5000/100 μ L are added in 96 orifice plates, setting control wells, model group, drug-treated group, and every group
3 multiple holes are set, 37 DEG C, 5 % CO are placed in2It is cultivated for 24 hours in incubator.The DMEM culture medium of 100 μ L is added in control group；Mould
The DMEM culture medium of 90 μ L is added in type group, and the 90 μ L of reducing blood lipid water extract of various concentration, concentration gradient group is added in drug-treated group
It is provided that after 25,50,100,200,400,600,800 μ g/ml, model group and drug-treated group incubate 4h in advance and 10 μ L is respectively added
H2O2, make H2O2Final concentration of 200 μm of ol/L continue to cultivate 20h measurement LDH, SOD index, as a result as shown in Fig. 2.
The reducing blood lipid water extract that this experiment uses various concentration has intervened PC-12 cell H2O2 damage model respectively, ties
Fruit shows, compared with model group, reducing blood lipid water extract can be substantially reduced the burst size of LDH in cell culture medium, can significantly improve
The content of SOD in cell；The burst size of LDH is successively decreased with being incremented by for drug concentration substantially, and the content of SOD is substantially with drug concentration
Be incremented by and be incremented by, illustrating product of the present invention not only has the left and right of reducing blood lipid, also with apparent antioxidation.
The above content is combine it is specific/further detailed description of the invention for preferred embodiment, cannot
Assert that specific implementation of the invention is only limited to these instructions.General technical staff of the technical field of the invention is come
It says, without departing from the inventive concept of the premise, some replacements or modifications can also be made to the embodiment that these have been described,
And these substitutions or variant are regarded as belonging to the scope of protection of the present invention.
Claims (10)
1. a kind of composition with effect for reducing blood fat, it is characterised in that: the composition by following parts by weight raw material system
It is standby to form: 0.1-10 parts of golden camellia tea, 0.1-10 parts of hawthorn, 0.1-10 parts of leaves of Hawthorn, 0.1-10 parts of Siraitia grosvenorii, cortex cinnamomi 0.1-10
Part, 0.1-10 parts of loguat leaf, 0.1-10 parts of sugarcane top and 0.1-10 parts of lophatherum gracile.
2. according to claim 1 with the composition of effect for reducing blood fat, it is characterised in that: 5 parts of golden camellia tea, hawthorn 10
Part, 5 parts of leaves of Hawthorn, 10 parts of Siraitia grosvenorii, 1 part of cortex cinnamomi, 1 part of loguat leaf, 1 part of sugarcane top and 1 part of lophatherum gracile.
3. according to claim 1 with effect for reducing blood fat composition, it is characterised in that: 3 parts of golden camellia tea, 8 parts of hawthorn,
2 parts of leaves of Hawthorn, 6 parts of Siraitia grosvenorii, 0.5 part of cortex cinnamomi, 0.5 part of loguat leaf, 0.5 part of sugarcane top and 0.5 part of lophatherum gracile.
4. according to claim 1 with effect for reducing blood fat composition, it is characterised in that: 2 parts of golden camellia tea, 6 parts of hawthorn,
3 parts of leaves of Hawthorn, 4 parts of Siraitia grosvenorii, 0.1 part of cortex cinnamomi, 0.1 part of loguat leaf, 0.1 part of sugarcane top and 0.1 part of lophatherum gracile.
5. -4 a kind of preparation method of composition with effect for reducing blood fat according to claim 1, it is characterised in that: including such as
Lower step: first selecting and clean golden camellia tea, hawthorn, leaves of Hawthorn, Siraitia grosvenorii, cortex cinnamomi, loguat leaf, sugarcane top, lophatherum gracile, dry
Each raw material is weighed according to aforementioned proportion afterwards, is pulverized and sieved, is uniformly mixed, is packed to get the composition with effect for reducing blood fat.
6. according to claim 5 with the preparation method of composition of effect for reducing blood fat, it is characterised in that: the side of the drying
Method is that shady place is dried, dried under the sun, being placed in 20-80 DEG C of baking oven one for being dried and being placed in freeze drier in freeze-drying
Kind.
7. according to claim 5 with the preparation method of composition of effect for reducing blood fat, it is characterised in that: mixed by pulverizing and sieving
After the composition that conjunction uniformly obtains conventionally extracts, obtained extract is passing through polishing purification, according to the normal of preparation
Blood fat reducing preparation is prepared in rule technique.
8. according to claim 7 with the preparation method of composition of effect for reducing blood fat, it is characterised in that: the conventional method
Extracting includes one of decoction, diacolation, dipping, ultrasound, reflux and steam distillation method.
9. according to claim 7 with the preparation method of composition of effect for reducing blood fat, it is characterised in that: the polishing purification
Method include water extract-alcohol precipitation, extraction, silica gel column chromatography separation, one in macroreticular resin post separation and ion exchange post separation
Kind.
10. a kind of preparation with effect for reducing blood fat as claimed in claim 7, it is characterised in that: the preparation includes powder, piece
Agent, capsule, granule, oral solution or pill.
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