CN108697795A - Gfral受体疗法 - Google Patents
Gfral受体疗法 Download PDFInfo
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- CN108697795A CN108697795A CN201680082844.2A CN201680082844A CN108697795A CN 108697795 A CN108697795 A CN 108697795A CN 201680082844 A CN201680082844 A CN 201680082844A CN 108697795 A CN108697795 A CN 108697795A
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- gfral
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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Applications Claiming Priority (1)
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| PCT/CN2016/074809 WO2017147742A1 (en) | 2016-02-29 | 2016-02-29 | Gfral receptor therapies |
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| CN108697795A true CN108697795A (zh) | 2018-10-23 |
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| JP (1) | JP2019510739A (enExample) |
| CN (1) | CN108697795A (enExample) |
| WO (1) | WO2017147742A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069636A (zh) * | 2016-03-04 | 2018-12-21 | 恩格姆生物制药公司 | 用于调节体重的组合物和方法 |
| WO2023274276A1 (zh) * | 2021-06-30 | 2023-01-05 | 上海津曼特生物科技有限公司 | 抗gfral抗体及其应用 |
| CN116444667A (zh) * | 2023-06-13 | 2023-07-18 | 上海驯鹿生物技术有限公司 | 一种靶向gdf15的全人源抗体及其应用 |
| WO2024183468A1 (zh) * | 2023-03-03 | 2024-09-12 | 北京志道生物科技有限公司 | 一种多肽分子 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2694092B1 (en) | 2011-04-08 | 2017-01-04 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| AU2017241161B2 (en) | 2016-03-31 | 2022-05-26 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
| US20190234935A1 (en) * | 2016-10-12 | 2019-08-01 | Janssen Biotech, Inc. | Methods for screening for modulators of gdf15-like biological activity |
| TWI724392B (zh) | 2018-04-06 | 2021-04-11 | 美商美國禮來大藥廠 | 生長分化因子15促效劑化合物及其使用方法 |
| EA202191105A1 (ru) * | 2018-10-22 | 2021-08-03 | Янссен Фармацевтика Нв | Слитые белки, полученные из глюкагоноподобного пептида 1 (glp1) и ростового фактора дифференцировки 15 (gdf15), и их применение |
| WO2021071837A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| BR112022017039A2 (pt) | 2020-02-28 | 2022-11-16 | Kallyope Inc | Agonistas de gpr40 |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ,インク. | Ampkアクチベーター |
| AU2021284131B2 (en) * | 2020-06-04 | 2025-05-29 | Daegu Gyeongbuk Institute Of Science And Technology | GFRAL-antagonistic antibody and use thereof |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| EP4314071A1 (en) | 2021-03-31 | 2024-02-07 | Cambridge Enterprise Limited | Therapeutic inhibitors of gdf15 signalling |
| IT202300006387A1 (it) * | 2023-03-31 | 2024-10-01 | Univ Degli Studi Roma La Sapienza | Inibitore del recettore gfral per uso nel trattamento della sclerosi laterale amiotrofica |
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| CN101854947A (zh) * | 2007-08-16 | 2010-10-06 | 圣文森特医院悉尼有限公司 | 用于调节巨噬细胞抑制因子(mic-1)活性的药剂和方法 |
| CN102321173A (zh) * | 2011-08-12 | 2012-01-18 | 中国医学科学院肿瘤研究所 | 人源化巨噬细胞抑制因子1单克隆抗体及其应用 |
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| US7247446B2 (en) * | 2002-03-05 | 2007-07-24 | Genentech, Inc. | PRO34128 nucleic acids |
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- 2016-02-29 JP JP2018540415A patent/JP2019510739A/ja active Pending
- 2016-02-29 EP EP16891935.5A patent/EP3423094A4/en not_active Withdrawn
- 2016-02-29 CN CN201680082844.2A patent/CN108697795A/zh active Pending
- 2016-02-29 WO PCT/CN2016/074809 patent/WO2017147742A1/en not_active Ceased
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| CN103533951A (zh) * | 2011-04-08 | 2014-01-22 | 安姆根有限公司 | 使用生长分化因子15(gdf-15)治疗或改善代谢障碍的方法 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069636A (zh) * | 2016-03-04 | 2018-12-21 | 恩格姆生物制药公司 | 用于调节体重的组合物和方法 |
| WO2023274276A1 (zh) * | 2021-06-30 | 2023-01-05 | 上海津曼特生物科技有限公司 | 抗gfral抗体及其应用 |
| WO2024183468A1 (zh) * | 2023-03-03 | 2024-09-12 | 北京志道生物科技有限公司 | 一种多肽分子 |
| CN116444667A (zh) * | 2023-06-13 | 2023-07-18 | 上海驯鹿生物技术有限公司 | 一种靶向gdf15的全人源抗体及其应用 |
| CN116444667B (zh) * | 2023-06-13 | 2023-09-01 | 上海驯鹿生物技术有限公司 | 一种靶向gdf15的全人源抗体及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017147742A1 (en) | 2017-09-08 |
| EP3423094A4 (en) | 2019-11-06 |
| EP3423094A1 (en) | 2019-01-09 |
| JP2019510739A (ja) | 2019-04-18 |
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