CN108686255B - Biological dressing for preventing scar formation and preparation method thereof - Google Patents
Biological dressing for preventing scar formation and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention discloses a biological dressing for preventing scar formation and a preparation method thereof. The biological dressing for preventing the scar formation comprises a packing material, a base material and a dressing medicament, wherein the dressing medicament consists of the following raw materials: sodium hyaluronate, composite active peptide, EGF, KGF, FGF, glycerol, hydroxyethyl cellulose, chitosan, phenoxyethanol, hamamelis extract, scutellaria root extract, raspberry extract, sanguisorba extract, onion extract and water. Also discloses a preparation method of the biological dressing for preventing scar formation. The scar-proof biological dressing contains hyaluronic acid, EGF, KGF, small molecule active peptide, various plant extracts and other bioactive components, has obvious effects of promoting healing, preventing and reducing scar formation on skin wounds, and can be used for treating and nursing various body surface wounds and problem skins.
Description
Technical Field
The invention relates to a biological dressing for preventing scar formation and a preparation method thereof.
Background
The repair of human skin injury is a complex physiological process, and the healing speed of the wound and the formation and proliferation of scars after healing are always puzzled by people. For this reason, there are efforts to find ideal dressings, including good biocompatibility, controlling and absorbing the exudate of the wound, preventing the invasion of bacteria and inhibiting the growth and reproduction of bacteria, protecting the new tissues, accelerating the healing of the wound, preventing and reducing scars, stopping bleeding and easing pain, good mechanical properties, and the like. None of the dressings have yet been able to meet and satisfy the above requirements.
With the development of molecular biology, the application of biomaterials in medical dressings has been increasingly researched, and a great deal of results have been obtained, such as collagen, growth factors, hyaluronic acid, chitosan, alginate and the like. CN1337270A discloses a wound dressing and a preparation method thereof, wherein collagen and hyaluronic acid are coated or adhered on a substrate surface as a wound dressing. CN1228338A discloses a multilayer composite dressing containing collagen and growth factors for promoting wound tissue repair. CN1335135A discloses an artificial skin powder containing sodium hyaluronate and its preparation method, wherein the powder is prepared from sodium hyaluronate and pharmacologically active substances (heparin, chondroitin sulfate, epidermal growth factor, etc.) and is used for treating burn and scald. CN1380109A discloses a chitosan, collagen and calcium alginate composite sponge biological dressing and a preparation process thereof, the method comprises the steps of compounding and crosslinking the substances, neutralizing the substances with a buffer solution until the PH value is 5-7, emulsifying, pre-freezing, and freeze-drying to obtain the chitosan collagen sponge biological dressing. CN1379146A discloses a compound (Ag + Ag)2O) a production process of the silver-containing antibacterial fabric, and the dressing with antibacterial effect can be produced.
The invention and the dressing product thereof mainly pay attention to the fact that the invention and the dressing product thereof play a good role in wound treatment in the links of protecting the wound environment, promoting wound healing and preventing wound infection, but do not relate to prevention and reduction of scar formation, and the generation of scars not only affects the beauty, but also can generate symptoms of unsmooth perspiration, serious itching and the like, thereby causing great pain to patients.
Disclosure of Invention
The invention aims to provide a biological dressing for preventing scar formation and a preparation method thereof, and the biological dressing can promote wound healing and prevent and reduce scar formation.
The technical scheme adopted by the invention is as follows:
a biological dressing for preventing scar formation comprises a packing material, a base material and a dressing medicament, wherein the dressing medicament is prepared from the following raw materials in percentage by mass:
the balance of water;
the composite active peptide comprises a short-chain peptide consisting of 3-10 amino acids.
In the biological dressing for preventing scar formation, the composite active peptide is composed of at least three of copper tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, acetyl tetrapeptide-9, tetrapeptide-30, pentapeptide-3, pentapeptide-18, hexapeptide-2, hexapeptide-9, hexapeptide-10, nonapeptide-1 and decapeptide-12.
In the biological dressing for preventing the scar formation, the components of the dressing medicament also comprise a pharmaceutically acceptable carrier accounting for 0-20% of the mass percent of the dressing medicament, and the carrier comprises at least one of a film-forming agent, a solvent, a gel material, a cross-linking agent, a humectant, a foaming agent, a surfactant or an excipient.
In the biological dressing for preventing the scar formation, the base material is a fiber fabric or a non-woven fabric.
The fiber fabric in the biological dressing base material for preventing the scar formation is at least one of cotton, wool, silk, hemp, bamboo, wood pulp, viscose fiber, chitosan fiber, activated carbon fiber, terylene, chinlon, polypropylene fiber, spandex, aramid fiber, acetate fiber and polyurethane fiber.
In the biological dressing for preventing the scar formation, the packing material is a polyethylene bag or an aluminum foil bag.
The preparation method of the biological dressing for preventing the scar formation comprises the following steps:
1) putting the base material into a packaging material, and sterilizing for later use;
2) mixing sodium hyaluronate with water, stirring and dissolving to obtain sodium hyaluronate solution;
3) mixing EGF, KGF, FGF, glycerol and water, and uniformly stirring to obtain a growth factor solution;
4) mixing compound active peptide, hydroxyethyl cellulose, chitosan, phenoxyethanol, hamamelis extract, scutellaria root extract, raspberry extract, sanguisorba extract and onion extract with water, and stirring uniformly to obtain compound active peptide solution;
5) mixing a sodium hyaluronate solution, a growth factor solution and a composite active peptide solution to obtain a dressing medicament;
6) filling the dressing agent into the packaging material obtained in the step 1), and fully infiltrating to obtain the biological dressing for preventing scar formation.
In the step 2) of the preparation method, the mass ratio of the sodium hyaluronate to the water is 1: (15-25).
In the step 5) of the preparation method, the volume ratio of the sodium hyaluronate solution to the growth factor solution to the composite active peptide solution is 1: 1: 8.
the invention has the beneficial effects that:
the scar-proof biological dressing contains hyaluronic acid, EGF, KGF, small molecule active peptide, various plant extracts and other bioactive components, has obvious effects of promoting healing, preventing and reducing scar formation on skin wounds, and can be used for treating and nursing various body surface wounds and problem skins.
Specifically, the method comprises the following steps:
the hyaluronic acid selected by the invention has almost all skin repairing functions of moisturizing, repairing, detumescence, antioxidation and the like, can be used as a medical dressing, and is used for treating and nursing dermatitis, eczema, skin allergy and superficial injury (such as sunburn).
The invention selects a plurality of small molecule active peptides with the functions of promoting repair and protecting skin as main components, and the small molecule active peptides can be directly absorbed by skin to play the effect in the modes of epithelial cell and intercellular space passive diffusion, carrier transmembrane transport, endocytosis and the like, and can generate good repair and protection effects on skin inflammation, superficial injury and sub-health skin.
Detailed Description
A biological dressing for preventing scar formation comprises a packing material, a base material and a dressing medicament, wherein the dressing medicament is prepared from the following raw materials in percentage by mass:
the composite active peptide comprises a short-chain peptide consisting of 3-10 amino acids.
The EGF, i.e. the growth factor, is an epidermal growth factor, and the KGF, i.e. the keratinocyte growth factor and the FGF, i.e. the fibroblast growth factor.
Preferably, the biological dressing for preventing scar formation comprises a packing material, a base material and a dressing medicament, wherein the dressing medicament is prepared from the following raw materials in percentage by mass:
preferably, in the biological dressing for preventing scar formation, the compound active peptide is composed of at least three of copper tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, acetyl tetrapeptide-9, tetrapeptide-30, pentapeptide-3, pentapeptide-18, hexapeptide-2, hexapeptide-9, hexapeptide-10, nonapeptide-1 and decapeptide-12.
Preferably, in the biological dressing for preventing scar formation, the dressing medicament further comprises a pharmaceutically acceptable carrier accounting for 0-20% of the mass percent of the dressing medicament, and the carrier comprises at least one of a film-forming agent, a solvent, a gel material, a cross-linking agent, a humectant, a foaming agent, a surfactant or an excipient.
Preferably, in the biological dressing for preventing scar formation, the substrate is a fiber fabric or a non-woven fabric.
Preferably, the fiber fabric in the biological dressing substrate for preventing scar formation is at least one of cotton, wool, silk, hemp, bamboo, wood pulp, viscose fiber, chitosan fiber, activated carbon fiber, terylene, chinlon, polypropylene fiber, spandex, aramid fiber, acetate fiber and polyurethane fiber.
Preferably, in the biological dressing for preventing scar formation, the packing material is a polyethylene bag or an aluminum foil bag.
The preparation method of the biological dressing for preventing the scar formation comprises the following steps:
1) putting the base material into a packaging material, and sterilizing for later use;
2) mixing sodium hyaluronate with water, stirring and dissolving to obtain sodium hyaluronate solution;
3) mixing EGF, KGF, FGF, glycerol and water, and uniformly stirring to obtain a growth factor solution;
4) mixing compound active peptide, hydroxyethyl cellulose, chitosan, phenoxyethanol, hamamelis extract, scutellaria root extract, raspberry extract, sanguisorba extract and onion extract with water, and stirring uniformly to obtain compound active peptide solution;
5) mixing a sodium hyaluronate solution, a growth factor solution and a composite active peptide solution to obtain a dressing medicament;
6) filling the dressing agent into the packaging material obtained in the step 1), and fully infiltrating to obtain the biological dressing for preventing scar formation.
Preferably, in step 2) of the preparation method, the mass ratio of sodium hyaluronate to water is 1: (15-25).
Preferably, in step 5) of the preparation method, the volume ratio of the sodium hyaluronate solution, the growth factor solution and the composite active peptide solution is 1: 1: 8.
the Hamamelis virginiana extract has the effects of moisturizing, whitening, promoting blood circulation, balancing skin pH value and grease secretion and repairing damaged skin, the radix scutellariae extract is a flavonoid extract and has the effects of inhibiting bacteria, resisting inflammation and removing free radicals, so that scar skin can be repaired and scar formation can be prevented, the raspberry extract contains a large amount of organic acid, saccharide, vitamin C and β -sitosterol, wherein the important nutrient component β -sitosterol has high permeability to the skin, so that moisture on the surface of the skin can be kept, skin metabolism is promoted, skin inflammation is inhibited, the auxiliary extensibility is good, smoothness and non-stickiness are achieved, tannin and triterpenoid saponin in the radix sanguisorbae extract can relax muscles and stimulate the circulation of blood, promote tissue regeneration and relieve pain, no scar is left on a skin wound, collagen can be promoted, the skin is complete and smooth and has no scar, the onion extract can remarkably improve the symptoms and the appearance of structural tissues of the scar, promote the texture recovery of hyperplastic erythema, pruritus and scar tissue, so that the beauty of the skin can be remarkably repaired, the scar is well, the tender, the scar is well, and the skin feels soft, and the skin tissue hardness can be quickly removed.
The present invention will be described in further detail with reference to specific examples. The starting materials used in the examples are, unless otherwise specified, commercially available from conventional sources.
Example 1:
example 1 a method of making a biological dressing comprising the steps of:
1) folding the non-woven fabric, putting into an aluminum foil bag, and sterilizing for later use;
2) taking 50g of sodium hyaluronate, adding 1000mL of ultrapure water, mixing, heating, stirring and dissolving to obtain a sodium hyaluronate solution;
3) mixing 0.5g of EGF, 0.25g of KGF, 0.25g of FGF, 100g of glycerol and 1000mL of ultrapure water, and uniformly stirring to obtain a growth factor solution;
4) mixing 50g of composite active peptide (5g of copper tripeptide-1, 20g of palmitoyl tripeptide-5, 5g of tetrapeptide-30, 5g of pentapeptide-3, 5g of pentapeptide-18, 5g of hexapeptide-2 and 5g of nonapeptide-1), 20g of hydroxyethyl cellulose, 15g of chitosan, 20g of phenoxyethanol, 5g of hamamelis extract, 20g of scutellaria baicalensis root extract, 10g of raspberry extract, 5g of sanguisorba officinalis extract, 10g of onion extract and 8000mL of ultrapure water, and uniformly stirring to obtain a composite active peptide solution;
5) mixing a sodium hyaluronate solution, a growth factor solution and a composite active peptide solution to obtain a dressing medicament;
6) filling the dressing agent into the packing material obtained in the step 1), wherein the dosage is preferably enough to fully soak the non-woven fabric inside, and after full soaking, the biological dressing in the embodiment 1 is obtained.
Example 2:
example 2 a method of making a biological dressing comprising the steps of:
1) folding the non-woven fabric, putting into an aluminum foil bag, and sterilizing for later use;
2) taking 50g of sodium hyaluronate, adding 1000mL of ultrapure water, mixing, heating, stirring and dissolving to obtain a sodium hyaluronate solution;
3) mixing 0.5g of EGF, 0.25g of KGF, 100g of glycerol and 1000mL of ultrapure water, and uniformly stirring to obtain a growth factor solution;
4) mixing 50g of composite active peptide (5g of copper tripeptide-1, 20g of palmitoyl tetrapeptide-7, 10g of acetyl tetrapeptide-9, 10g of hexapeptide-10 and 5g of nonapeptide-1), 20g of hydroxyethyl cellulose, 15g of chitosan, 20g of phenoxyethanol, 5g of witch hazel extract, 20g of radix scutellariae extract, 10g of raspberry extract, 5g of sanguisorba extract, 10g of onion extract and 8000mL of ultrapure water, and uniformly stirring to obtain a composite active peptide solution;
5) mixing a sodium hyaluronate solution, a growth factor solution and a composite active peptide solution to obtain a dressing medicament;
6) filling the dressing agent into the packing material obtained in the step 1), wherein the dosage is preferably enough to fully soak the non-woven fabric inside, and after full soaking, obtaining the biological dressing in the embodiment 2.
Example 3:
example 3 a method of making a biological dressing comprising the steps of:
1) folding the non-woven fabric, putting into an aluminum foil bag, and sterilizing for later use;
2) taking 50g of sodium hyaluronate, adding 1000mL of ultrapure water, mixing, heating, stirring and dissolving to obtain a sodium hyaluronate solution;
3) mixing 0.25g of EGF, 0.25g of KGF, 0.25g of FGF, 100g of glycerol and 1000mL of ultrapure water, and uniformly stirring to obtain a growth factor solution;
4) mixing 50g of compound active peptide (5g of palmitoyl tripeptide-5, 5g of palmitoyl tetrapeptide-7, 15g of acetyl tetrapeptide-9, 5g of tetrapeptide-30, 5g of pentapeptide-3, 5g of hexapeptide-9, 5g of hexapeptide-10 and 5g of decapeptide-12), 20g of hydroxyethyl cellulose, 15g of chitosan, 20g of phenoxyethanol, 5g of hamamelis extract, 20g of scutellaria root extract, 10g of raspberry extract, 5g of sanguisorba extract, 10g of onion extract and 9000mL of water, and stirring uniformly to obtain a compound active peptide solution;
5) mixing a sodium hyaluronate solution, a growth factor solution and a composite active peptide solution to obtain a dressing medicament;
6) filling the dressing agent into the packing material obtained in the step 1), wherein the dosage is preferably enough to fully soak the non-woven fabric inside, and after full soaking, the biological dressing of the embodiment 3 is obtained.
Performance evaluation:
mono-super pulse CO2Dot matrix laser postoperative repair
Finding the depressed scar after mild to severe acne and receiving super-pulse CO280 patients treated by lattice laser, 32 males and 48 females, age 18-40. The samples were randomized into four groups of 20 persons, three of which volunteer tested the examples and another tested the comparative examples. After operation, the three groups of the embodiment are externally applied for 20min every day by adopting the dressing of the embodiment 1-3 respectively, and are continuously used for 10 days; in the comparative example, the dressing of the example was not used, but a self-made cold water ice bag was used for cold compress, and the cold compress was also applied for 20min every day for 10 days. During the test period, the patients all require strict sun protection after operation, and the chlortetracycline hydrochloride eye ointment is normally used for external use for 2 times/day for each groupFor three consecutive days.
Scoring according to inflammatory reaction on the 5 th day of the test, scoring according to the degree from 1 to 5, wherein 1 indicates no erythema, edema and burning sensation; score 5 indicates marked erythema, edema, burning and burning pain. The results are shown in table 1, with scores shown as the average score of 20 people per group.
TABLE 1 inflammatory response score
| Test group | Example 1 | Example 2 | Example 3 | Comparative example |
| Average score | 2.1 | 2.5 | 2.3 | 3.4 |
Volunteers were instructed to record the time to wound scab, the time to first scab exfoliation and the time to total scab exfoliation, the average of the times (days) being shown in table 2.
TABLE 2 average escharosis and decrustation times
| Test group | Example 1 | Example 2 | Example 3 | Comparative example |
| Time of scab on wound surface (Tian) | 1.3 | 1.5 | 1.4 | 1.7 |
| Time (day) of first scab skin falling | 4.8 | 5.0 | 4.9 | 5.5 |
| Time of total crust detachment (Tian) | 5.8 | 6.1 | 6.0 | 8.2 |
Second, repairing acne scar
40 acne patients were recruited to undergo scar repair tests, 15 men and 25 women aged 18-35 years. The samples were randomized into four groups of 10 persons, three of which volunteer tested the examples and another tested the comparative examples. The three groups of the embodiment are respectively externally applied with the dressing of the embodiment 1-3 for 20min every day for 15 days; in the comparative example, the dressing of the example was not used, but a commercially available ordinary dressing was selected for external application, and the dressing was also applied for 20min every day for 15 days.
The volunteers are scored according to the skin lesion forms, and are scored according to the degree of erythema/pigmentation from 0 to 5, wherein 0 represents observation under natural light and no macroscopic erythema/pigmentation; score 3 indicates moderate erythema/pigmentation, reddish/tan in color, observed under natural light; score 5 indicates severe erythema/pigmentation, bright red/dark lift observed under natural light.
The results of the scoring for acne scar repair are shown in table 3, and the scores are the average scores.
TABLE 3 acne scar repair Effect score
| Test group | Example 1 | Example 2 | Example 3 | Comparative example |
| Before treatment | 4.5 | 4.5 | 4.2 | 4.5 |
| Treatment day 5 | 3.5 | 3.8 | 3.6 | 4.2 |
| Treatment of 1 stDay 0 | 2.4 | 2.7 | 2.6 | 3.3 |
| Treatment day 15 | 1.2 | 1.6 | 1.5 | 2.8 |
From the above performance evaluation results, it is understood that the dressing of the present invention can promote wound healing, prevent and reduce scar formation.
Claims (7)
1. A biological dressing for preventing scar formation comprises a packaging material, a base material and a dressing medicament, and is characterized in that: the dressing medicament is prepared from the following raw materials in percentage by mass:
the compound active peptide consists of at least three of copper tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, acetyl tetrapeptide-9, tetrapeptide-30, pentapeptide-3, pentapeptide-18, hexapeptide-2, hexapeptide-9, hexapeptide-10, nonapeptide-1 and decapeptide-12;
the base material is a fiber fabric or a non-woven fabric.
2. The biological dressing for preventing scar formation as claimed in claim 1, wherein: the dressing agent further comprises a pharmaceutically acceptable carrier accounting for 0-20% of the dressing agent by mass, wherein the carrier comprises at least one of a film forming agent, a solvent, a gel material, a cross-linking agent, a humectant, a foaming agent, a surfactant or an excipient.
3. The biological dressing for preventing scar formation as claimed in claim 1, wherein: the fiber fabric in the base material is at least one of cotton, wool, silk, hemp, bamboo, wood pulp, viscose, chitosan fiber, activated carbon fiber, terylene, chinlon, polypropylene fiber, spandex, aramid fiber, acetate fiber and polyurethane fiber.
4. The biological dressing for preventing scar formation as claimed in claim 1, wherein: the packing material is a polyethylene bag or an aluminum foil bag.
5. The method for preparing a biological dressing for preventing scar formation as claimed in any one of claims 1 to 4, wherein the biological dressing comprises: the method comprises the following steps:
1) putting the base material into a packaging material, and sterilizing for later use;
2) mixing sodium hyaluronate with water, stirring and dissolving to obtain sodium hyaluronate solution;
3) mixing EGF, KGF, FGF, glycerol and water, and uniformly stirring to obtain a growth factor solution;
4) mixing compound active peptide, hydroxyethyl cellulose, chitosan, phenoxyethanol, hamamelis extract, scutellaria root extract, raspberry extract, sanguisorba extract and onion extract with water, and stirring uniformly to obtain compound active peptide solution;
5) mixing a sodium hyaluronate solution, a growth factor solution and a composite active peptide solution to obtain a dressing medicament;
6) filling the dressing agent into the packaging material obtained in the step 1), and fully infiltrating to obtain the biological dressing for preventing scar formation.
6. The method for preparing a biological dressing for preventing scar formation according to claim 5, wherein the method comprises the following steps: in the step 2), the mass ratio of the sodium hyaluronate to the water is 1: (15-25).
7. The method for preparing a biological dressing for preventing scar formation according to claim 5, wherein the method comprises the following steps: in the step 5), the volume ratio of the sodium hyaluronate solution to the growth factor solution to the composite active peptide solution is 1: 1: 8.
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| CN108743921A (en) * | 2018-05-24 | 2018-11-06 | 广州芬森医学科技有限公司 | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed |
| CN111166929A (en) * | 2018-11-09 | 2020-05-19 | 上海弗霓生物科技有限公司 | Wet wound dressing and preparation method thereof |
| CN109731126A (en) * | 2019-01-25 | 2019-05-10 | 芬森健康科技(广州)中心(有限合伙) | A kind of biological dressing and preparation method thereof with reparation skin function |
| CN111870730A (en) * | 2020-08-10 | 2020-11-03 | 海南芬森医疗器械有限公司 | Medical dressing for chronic wound surface and preparation method thereof |
| CN111921005A (en) * | 2020-08-29 | 2020-11-13 | 山东百多安医疗器械股份有限公司 | Preparation method of hemostatic and antibacterial dressing containing herba Cephalanoploris extract |
| CN115463243B (en) * | 2022-08-18 | 2023-09-15 | 南通大学 | Nanometer dressing for inhibiting scar hyperplasia and preparation method thereof |
| CN117298321A (en) * | 2023-09-22 | 2023-12-29 | 山东融元康医疗科技有限公司 | Medical skin care dressing and preparation method thereof |
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| CN106176688A (en) * | 2016-08-16 | 2016-12-07 | 深圳市华生元基因工程发展有限公司 | A kind of wound repair liquid and preparation method thereof |
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