CN108653790A - A kind of biological dressing of prevention and reduction scar formation - Google Patents
A kind of biological dressing of prevention and reduction scar formation Download PDFInfo
- Publication number
- CN108653790A CN108653790A CN201810505270.6A CN201810505270A CN108653790A CN 108653790 A CN108653790 A CN 108653790A CN 201810505270 A CN201810505270 A CN 201810505270A CN 108653790 A CN108653790 A CN 108653790A
- Authority
- CN
- China
- Prior art keywords
- biological dressing
- hyaluronic acid
- growth factor
- parts
- scar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
Abstract
The invention discloses the biological dressings that a kind of prevention and reduction scar are formed.This biological dressing is made of base material and attachment liquid pharmaceutical on base material, and liquid pharmaceutical is made of raw material below：Water, gradient molecular weight hyaluronic acid compositions, composite reactive peptide, growth factor compounding, glycerine, hydroxy ethyl fiber, xanthans, sodium alginate, chitosan, Phenoxyethanol and plant extracts.The preparation method for the biological dressing that this prevention and reduction scar are formed is also disclosed that simultaneously.A kind of biological dressing is prepared by compounding gradient hyaluronic acid, small active peptides, growth factor and natural plant extracts isoreactivity component in the present invention, this biological dressing has the function of significantly promoting healing, prevents and reduce scar formation to skin trauma, can be used for the treatment and nursing of various body surface wounds and problem skin.
Description
Technical field
The present invention relates to the biological dressings that a kind of prevention and reduction scar are formed.
Background technology
With the development of molecular biology, application study of the biomaterial in medical dressing is increasing, and achieves
A large amount of achievements, such as collagen, growth factor, hyaluronic acid, chitosan, alginates.CN1337270A discloses a kind of wound
Mouth dressing and preparation method, this method are that collagen and hyaluronic acid are coated on to a base material table in a manner of being coated with or adhering
Wound dressing is used as on face.CN1228338A discloses a kind of promotion wound tissue and repairs, contains collagen and growth factor
MULTILAYER COMPOSITE dressing.CN1335135A discloses a kind of artificial skin powder agent and production method containing Sodium Hyaluronate,
This method is that Sodium Hyaluronate and pharmacological active substance (heparin, chondroitin sulfate, epidermal growth factor etc.) are made powder and are used for
Burn and scald.CN1380109A discloses a kind of chitosan, collagen and calcium alginate compounded spongy biological dressing and its preparation process,
This method be neutralized to by the compounding of these substances, crosslinking, with buffer solution PH be 5~7, after emulsification through pre-freeze, freeze-drying
It is made.CN1379146A discloses a kind of compound (Ag+Ag2O) the production technology of silver-containing antibacterial fabric can be produced with antibacterial
The dressing of effect.
The above invention and its casting product, principal concern is all in protection wound climate, promotion wound healing, prevention wound
In the link of infection, although play the role of on Wound healing and bone regeneration it is preferable, be not directed to prevent and reduce scar formed, and
The generation of scar not only influences beauty, and will produce perspire it is unsmooth, serious disturb the symptoms such as itch, cause great pain to patient
It is bitter.
Invention content
The purpose of the present invention is to provide the biological dressings that a kind of prevention and reduction scar are formed, and this biological dressing can
Wound healing, prevention and reduction scar is promoted to be formed.
The technical solution used in the present invention is：
A kind of biological dressing of prevention and reduction scar formation is by base material and to adhere to liquid pharmaceutical group on base material
At this liquid pharmaceutical is made of the raw material of following mass parts：
In terms of the relative molecular weight Mr of hyaluronic acid, gradient molecular weight hyaluronic acid compositions are by the original of following mass parts
Material composition：
In this biological dressing, composite reactive peptide includes the short-chain peptide of 3~10 amino acid composition.
In this biological dressing, composite reactive peptide is by copper tripeptides -1, palmityl tripeptides -5, palmityl tetrapeptide -7, acetyl group
At least four in tetrapeptide -9, tetrapeptide -30, pentapeptide -3, pentapeptide -18, hexapeptide -2, hexapeptide -9, hexapeptide -10, nonapeptide -1, decapeptide -12
Kind composition.
In this biological dressing, growth factor compound is made of the raw material of following mass percent：Epidermal growth factor
40%~80%, keratinocyte growth factor 10%~40%, fibroblast growth factor 5 %~30%.
In this biological dressing, plant extracts is made of the raw material of following mass parts：
In this biological dressing, base material is cotton fabric, wool fabric, silk fabrics, linen, bamboo fabric, wood pulp, viscose glue fibre
Dimension, chitosan fiber, activated carbon fibre, terylene, polyamide fibre, polypropylene fibre, spandex, aramid fiber, acetate fiber, polyurethane fiber, non-woven fabrics
In one of which.
The preparation method for the biological dressing that this prevention and reduction scar are formed, includes the following steps：
One, liquid pharmaceutical is prepared
1) gradient molecular weight hyaluronic acid compositions and water are mixed, stirs evenly, obtains gradient hyaluronic acid solution；
2) growth factor compound, glycerol and water are mixed, stirs evenly, obtains growth factor solution；
3) by composite reactive peptide, hydroxyethyl cellulose, xanthans, sodium alginate, chitosan, Phenoxyethanol, plant extract
Object and water mixing, stir evenly, and obtain composite reactive peptide combination liquid；
4) gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid are mixed, stirs evenly, obtains
Liquid pharmaceutical；
Two, biological dressing is prepared
Liquid pharmaceutical is attached in the method for being coated with, adhering or impregnate on base material, is prevented and reduce scar to be formed
Biological dressing.
It prepares in liquid pharmaceutical step, in gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid
The mass ratio of water is 1：1：8.
The beneficial effects of the invention are as follows：
The present invention is living by compounding gradient hyaluronic acid, small active peptides, growth factor and natural plant extracts etc.
Property component be prepared a kind of biological dressing, this biological dressing, which has skin trauma, significant to be promoted to heal, prevent and subtract
The effect that few scar is formed, can be used for the treatment and nursing of various body surface wounds and problem skin.
Specific implementation mode
A kind of biological dressing of prevention and reduction scar formation is by base material and to adhere to liquid pharmaceutical group on base material
At this liquid pharmaceutical is made of the raw material of following mass parts：
Further, in terms of the relative molecular weight Mr of hyaluronic acid, gradient molecular weight hyaluronic acid compositions are by following
The raw material of mass parts forms：
Further, in this biological dressing, composite reactive peptide includes the short-chain peptide of 3~10 amino acid composition.
Preferably, in this biological dressing, composite reactive peptide by copper tripeptides -1, palmityl tripeptides -5, palmityl tetrapeptide -7,
In acetyl group tetrapeptide -9, tetrapeptide -30, pentapeptide -3, pentapeptide -18, hexapeptide -2, hexapeptide -9, hexapeptide -10, nonapeptide -1, decapeptide -12
At least four compositions.
Further, in this biological dressing, growth factor compound is made of the raw material of following mass percent：Epidermis
Growth factor (EGF) 40%~80%, keratinocyte growth factor (KGF) 10%~40%, fibroblast growth factor
(FGF) 5%~30%.
Preferably, in this biological dressing, plant extracts is made of the raw material of following mass parts：
Further, in this biological dressing, base material is cotton fabric, wool fabric, silk fabrics, linen, bamboo fabric, wood
Slurry, viscose rayon, chitosan fiber, activated carbon fibre, terylene, polyamide fibre, polypropylene fibre, spandex, aramid fiber, acetate fiber, polyurethane are fine
One of which in dimension, non-woven fabrics.
The preparation method for the biological dressing that this prevention and reduction scar are formed, includes the following steps：
One, liquid pharmaceutical is prepared
1) gradient molecular weight hyaluronic acid compositions and water are mixed, stirs evenly, obtains gradient hyaluronic acid solution；
2) growth factor compound, glycerol and water are mixed, stirs evenly, obtains growth factor solution；
3) by composite reactive peptide, hydroxyethyl cellulose, xanthans, sodium alginate, chitosan, Phenoxyethanol, plant extract
Object and water mixing, stir evenly, and obtain composite reactive peptide combination liquid；
4) gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid are mixed, stirs evenly, obtains
Liquid pharmaceutical；
Two, biological dressing is prepared
Liquid pharmaceutical is attached in the method for being coated with, adhering or impregnate on base material, is prevented and reduce scar to be formed
Biological dressing.
Preferably, it prepares in liquid pharmaceutical step, gradient hyaluronic acid solution, growth factor solution and composite reactive peptide group
The mass ratio for closing water in liquid is 1：1：8.
Present disclosure is described in further detail below by way of specific embodiment.It is former used in embodiment
Material unless otherwise specified, can be obtained from routine business approach.
Embodiment 1：
The preparation method of 1 biological dressing of embodiment, includes the following steps：
1) 25 grams of high molecular weight hyaluronic acids, 5 grams of middle-molecular-weihydroxyethyl hyaluronic acids, 15 grams of low-molecular-weight hyaluronic acids, 5 are weighed
Gram oligomerization hyaluronic acid adds 1000mL ultra-pure waters, heating stirring dissolving to obtain gradient hyaluronic acid solution；
2) 0.5gEGF, 0.25gKGF, 0.25gFGF, 150g glycerine and 1000mL ultra-pure waters are weighed, is mixed evenly,
Obtain growth factor solution；
3) weigh 5g copper tripeptides -1,20g palmityls tetrapeptide -7,10g acetyl group tetrapeptides -9,5g pentapeptides -3,5g hexapeptides -10,
5g nonapeptides -1,20g hydroxyethyl celluloses, 30g xanthans, 20g sodium alginates, 20g Phenoxyethanols, 5g hamamelis extracts, 10g
Radix scutellariae root extract, 10g Fructus Rubi extracts, 5g Radix Sangusorbae extracts, 5g Bulbus Allii Cepae extracts and the mixing of 8000mL ultra-pure waters, stirring
Uniformly, composite reactive peptide combination liquid is obtained；
4) gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid are mixed, stirs evenly, impregnates
Onto non-woven fabrics, dosage is advisable with can fully soak non-woven fabrics, obtains the biological dressing of embodiment 1.
Embodiment 2：
The preparation method of 2 biological dressing of embodiment, includes the following steps：
1) weigh 20 grams of high molecular weight hyaluronic acids, 10 grams of middle-molecular-weihydroxyethyl hyaluronic acids, 10 grams of low-molecular-weight hyaluronic acids,
10 grams of oligomerization hyaluronic acids add 1000mL ultra-pure waters, heating stirring dissolving to obtain gradient hyaluronic acid solution；
2) 0.5gEGF, 0.25gKGF, 0.25gFGF, 100g glycerine and 1000mL ultra-pure waters are weighed, is mixed evenly,
Obtain growth factor solution；
3) 5g palmityl tripeptides -5,5g palmityls tetrapeptide -7,15g acetyl group tetrapeptides -9,5g tetrapeptides -30,5g pentapeptides-are weighed
3,5g hexapeptides -9,5g hexapeptides -10,5g decapeptides -12,20g hydroxyethyl celluloses, 20g xanthans, 20g sodium alginates, 10g shells are poly-
Sugar, 20g Phenoxyethanols, 5g hamamelis extracts, 20g radix scutellariaes root extract, 10g Fructus Rubi extracts, 5g Radix Sangusorbae extracts,
10g Bulbus Allii Cepae extracts and the mixing of 8000mL ultra-pure waters, stir evenly, and obtain composite reactive peptide combination liquid；
4) gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid are mixed, stirs evenly, impregnates
Onto non-woven fabrics, dosage is advisable with can fully soak non-woven fabrics, obtains the biological dressing of embodiment 2.
Embodiment 3：
The preparation method of 3 biological dressing of embodiment, includes the following steps：
1) weigh 25 grams of high molecular weight hyaluronic acids, 10 grams of middle-molecular-weihydroxyethyl hyaluronic acids, 10 grams of low-molecular-weight hyaluronic acids,
5 grams of oligomerization hyaluronic acids add 1000mL ultra-pure waters, heating stirring dissolving to obtain gradient hyaluronic acid solution；
2) 0.5gEGF, 0.25gKGF, 0.25gFGF, 250g glycerine and 1000mL ultra-pure waters are weighed, is mixed evenly,
Obtain growth factor solution；
3) 5g copper tripeptides -1,20g palmityl tripeptides -5,5g tetrapeptides -30,5g pentapeptides -3,5g pentapeptides -18,5g hexapeptides-are weighed
2,5g nonapeptides -1,20g hydroxyethyl celluloses, 20g xanthans, 10g sodium alginates, 20g chitosans, 20g Phenoxyethanols, 5g gold threads
Prunus mume extract, 20g radix scutellariaes root extract, 10g Fructus Rubi extracts, 5g Radix Sangusorbae extracts, 10g Bulbus Allii Cepae extracts and 8000mL are super
Pure water mixes, and stirs evenly, and obtains composite reactive peptide combination liquid；
4) gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid are mixed, stirs evenly, impregnates
Onto non-woven fabrics, dosage is advisable with can fully soak non-woven fabrics, obtains the biological dressing of embodiment 3.
Comparative example 1：
Whether comparative example 1 gradient hyaluronic acid solution or not when preparing, remaining is identical with embodiment 2, thus obtains pair
The biological dressing of ratio 1.
Comparative example 2：
Comparative example 2 or not growth factor solution, remaining is identical with embodiment 2, thus obtains comparative example when preparing
2 biological dressing.
Comparative example 3：
Comparative example 3 or not composite reactive peptide combination liquid, remaining is identical with embodiment 2, thus obtains pair when preparing
The biological dressing of ratio 3.
Performance evaluation：
One, Super pulse CO2It is repaired after dot matrix laser operation
It finds gently to depressed scar after severe acne, and receives Super pulse CO2The patient of dot matrix laser therapy 70,
Middle male 30, women 40,18~39 years old age.Seven groups are randomly divided into, every group of 10 people, wherein three groups of aspiration testing example
1~3, three groups of test comparison examples 1~3, last group as a contrast test by example.Postoperative, implementation is respectively adopted in three groups of embodiment
The biological dressing of example 1~3, the biological dressing that comparative example 1~3 is respectively adopted of three groups of comparative example is sooner or later each daily to be applied with 1 time,
Continuous use 10 days.Homemade cold water ice bag is selected to carry out cold compress example as a contrast simultaneously, it is equally sooner or later each daily to be applied with once,
Continuous use 10 days.During experiment, patient is required to postoperative stringent sun-proof, every group of just common aureomycin hydrochloride eye ointment external application 2
Times/day, continuous three days.
Scored according to inflammatory reaction within the 5th day in experiment, scored from 1 point~5 points by degree, 1 point indicate without
Erythema, oedema, burning heat sensation；5 points indicate apparent erythema, oedema and scorching hot, cusalgia.Test result is shown in Table 1, shown in
It is divided into the average mark of every group of 10 people.
1 inflammatory reaction of table is scored
| Test group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Reference examples |
| Average mark | 2.4 | 2.2 | 2.3 | 2.6 | 2.5 | 2.9 | 3.4 |
Volunteer is advised to record surface of a wound scab forming time, decrustation time and whole decrustation times at first, the time
Average value (day) can be shown in Table 2.
Table 2 averagely incrustation and decrustation time
Two, acne scars reparation
70 patients with acne of collection carry out scar repairing test, wherein male 28, women 42,18~30 years old age.
Seven groups are randomly divided into, every group of 10 people, wherein three groups of aspiration testing example 1~3, three groups of test comparison examples 1~3, last group
Example is tested as a contrast.The biological dressing that Examples 1 to 3 is respectively adopted of three groups of embodiment, three groups of comparative example are respectively adopted
The biological dressing of comparative example 1~3, it is sooner or later each daily to be applied with once, it is used continuously 15 days；Reference examples select commercially available common dressing
It is applied with, it is same to be applied with sooner or later once daily, it is used continuously 15 days.
Volunteer scores according to skin lesion form, scores from 0 point~5 points by erythema/pigment degree, wherein 0 point
It indicates to observe under available light, is visible by naked eyes erythema/pigmentation；3 points indicate to observe under available light, moderate erythema/color
Plain calm, color is compared with red yellow brown；5 points indicate to observe under available light, severe erythema/pigmentation, and color is scarlet/deep to take off
Color.
The appraisal result of acne scars reparation is shown in Table 3, and the score value is average mark.
3 acne scars repairing effect of table scores
| Test group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Reference examples |
| Before treatment | 4.5 | 4.5 | 4.4 | 4.4 | 4.5 | 4.4 | 4.6 |
| It treats the 5th day | 3.5 | 3.4 | 3.6 | 3.8 | 3.7 | 3.9 | 4.2 |
| It treats the 10th day | 2.7 | 2.3 | 2.6 | 2.8 | 2.7 | 2.9 | 3.5 |
| It treats the 15th day | 1.6 | 1.2 | 1.5 | 1.7 | 1.8 | 2.0 | 3.0 |
From above-mentioned Evaluation results it is found that the dressing of the present invention can promote wound healing, prevention and reduce scar
It is formed.
Compared with prior art, biological dressing of the invention has the following advantages that：
1) hyaluronic acid of different molecular weight is carried out scientific matching by the present invention, forms gradient hyaluronic acid system, has
The performance more various than the hyaluronic acid of unimodal molecular weight and effect can give full play to hyaluronic acid in skin repair, protection
With whole effects in terms of nursing, and stability is protected the effect of make Related product；
2) it is main that the present invention, which selects the several small active peptides with promotion reparation and protection skin correlation function,
Composition, since small active peptides can pass through epithelial cell and space between cells Passive diffusion, carrier transmembrane transport and cell endocytic
Etc. modes, directly absorbed by skin and play effect, can to scytitis, shallow damage and inferior health skin generate it is good
Reparation and protective effect.
3) growth factor these active constituents selected by have skin trauma and significant promote to heal, prevent and subtract
The effect that few scar is formed, can be used for the treatment and nursing of various body surface wounds and problem skin.
4) in the plant extracts used in the present invention：Hamamelis extract has moisturizing, Milk Protein, and blood is promoted to follow
Ring, balance skin pH value and fat secretion repair the effect for being damaged skin；Radix scutellariae root extract is a kind of flavone extract,
Have the function of antibacterial, anti-inflammatory, removing free radical, scarred skin can be repaired, prevent scar from being formed；Contain in Fructus Rubi extract
Have and largely contain organic acid, carbohydrate and vitamin C and cupreol, wherein important nutritional ingredient cupreol, has skin
There is very high permeability, the moisture of skin surface can be kept, promote skin metabolism, inhibits scytitis, auxiliary malleability is good,
It is smooth not stick；Tannin in Radix Sangusorbae extract and triterpenoid saponin energy relaxing tendons and activating collaterals, myogenic pain relieving repair skin wound and do not stay scar
Trace can promote collagen to generate, and make skin complete and smooth, no scar；Bulbus Allii Cepae extract can significantly improve the symptom of scar
With structure organization appearance, promotes the recovery of the erythema, itch, scar tissue quality of hyperplastic scar, can significantly repair skin
The aesthetics of scar, the preferable hardness and skin feel for softening scar quickly eliminate the inflammation of scar tissue and touch a tender spot and feels.
Claims (9)
1. the biological dressing that a kind of prevention and reduction scar are formed, it is characterised in that：By base material and adhere to liquid on base material
Medicament forms, and the liquid pharmaceutical is made of the raw material of following mass parts：
10000 parts of water；
10~80 parts of gradient molecular weight hyaluronic acid compositions；
20~80 parts of composite reactive peptide；
0.5~2 part of growth factor compound；
50~150 parts of glycerine；
10~30 parts of hydroxyethyl cellulose；
5~40 parts of xanthans；
5~30 parts of sodium alginate；
0~30 part of chitosan；
10~30 parts of Phenoxyethanol；
5~80 parts of plant extracts.
2. the biological dressing that a kind of prevention according to claim 1 and reduction scar are formed, it is characterised in that：With hyalomitome
The relative molecular weight Mr meters of acid, gradient molecular weight hyaluronic acid compositions are made of the raw material of following mass parts：
10~40 parts of the high molecular weight hyaluronic acid of Mr >=2,000,000；
200000≤Mr<1~20 part of 2000000 middle-molecular-weihydroxyethyl hyaluronic acid；
10000≤Mr<1~20 part of 200000 low-molecular-weight hyaluronic acid；
Mr<1~20 part of 10000 oligomerization hyaluronic acid.
3. the biological dressing that a kind of prevention according to claim 1 and reduction scar are formed, it is characterised in that：Composite reactive
Peptide includes the short-chain peptide of 3~10 amino acid composition.
4. the biological dressing that a kind of prevention according to claim 3 and reduction scar are formed, it is characterised in that：Composite reactive
Peptide is by copper tripeptides -1, palmityl tripeptides -5, palmityl tetrapeptide -7, acetyl group tetrapeptide -9, tetrapeptide -30, pentapeptide -3, pentapeptide -18, six
At least four compositions in peptide -2, hexapeptide -9, hexapeptide -10, nonapeptide -1, decapeptide -12.
5. the biological dressing that a kind of prevention according to claim 1 and reduction scar are formed, it is characterised in that：Growth factor
Compound is made of the raw material of following mass percent：Epidermal growth factor 40%~80%, keratinocyte growth factor 10%
~40%, fibroblast growth factor 5 %~30%.
6. the biological dressing that a kind of prevention according to claim 1 and reduction scar are formed, it is characterised in that：Plant extract
Object is made of the raw material of following mass parts：
7. the biological dressing that a kind of prevention according to claim 1 and reduction scar are formed, it is characterised in that：Base material is cotton
Fabric, wool fabric, silk fabrics, linen, bamboo fabric, wood pulp, viscose rayon, chitosan fiber, activated carbon fibre, terylene, brocade
One of which in synthetic fibre, polypropylene fibre, spandex, aramid fiber, acetate fiber, polyurethane fiber, non-woven fabrics.
8. the preparation method for the biological dressing that a kind of prevention of claim 1~7 any one of them and reduction scar are formed, special
Sign is：Include the following steps：
One, liquid pharmaceutical is prepared
1) gradient molecular weight hyaluronic acid compositions and water are mixed, stirs evenly, obtains gradient hyaluronic acid solution；
2) growth factor compound, glycerol and water are mixed, stirs evenly, obtains growth factor solution；
3) by composite reactive peptide, hydroxyethyl cellulose, xanthans, sodium alginate, chitosan, Phenoxyethanol, plant extracts and
Water mixes, and stirs evenly, and obtains composite reactive peptide combination liquid；
4) gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid are mixed, stirs evenly, obtains liquid
Medicament；
Two, biological dressing is prepared
Liquid pharmaceutical is attached in the method for being coated with, adhering or impregnate on base material, the life of scar formation is prevented and reduced
Object dressing.
9. the preparation method for the biological dressing that a kind of prevention according to claim 8 and reduction scar are formed, feature exist
In：It prepares in liquid pharmaceutical step, the matter of water in gradient hyaluronic acid solution, growth factor solution and composite reactive peptide combination liquid
Amount is than being 1：1：8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810505270.6A CN108653790A (en) | 2018-05-24 | 2018-05-24 | A kind of biological dressing of prevention and reduction scar formation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810505270.6A CN108653790A (en) | 2018-05-24 | 2018-05-24 | A kind of biological dressing of prevention and reduction scar formation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108653790A true CN108653790A (en) | 2018-10-16 |
Family
ID=63777834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810505270.6A Pending CN108653790A (en) | 2018-05-24 | 2018-05-24 | A kind of biological dressing of prevention and reduction scar formation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108653790A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743921A (en) * | 2018-05-24 | 2018-11-06 | 广州芬森医学科技有限公司 | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed |
| CN109453411A (en) * | 2018-12-03 | 2019-03-12 | 广州润虹医药科技股份有限公司 | A kind of chitosan dressing |
| CN109731126A (en) * | 2019-01-25 | 2019-05-10 | 芬森健康科技(广州)中心(有限合伙) | A kind of biological dressing and preparation method thereof with reparation skin function |
| CN109893467A (en) * | 2019-03-20 | 2019-06-18 | 江苏朗沁科技有限公司 | A kind of preparation method of face-beautifying dressing |
| CN114306714A (en) * | 2021-12-31 | 2022-04-12 | 安徽科门生物科技有限公司 | Method for using stem cell composite biological material for skin regeneration and repair |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104080438A (en) * | 2011-11-30 | 2014-10-01 | 味之素株式会社 | Whitening cosmetic |
| CN204072471U (en) * | 2014-06-20 | 2015-01-07 | 唐山市博世德医疗器械有限公司 | A kind of Silica hydrogel scar plaster |
| CN104856892A (en) * | 2014-11-14 | 2015-08-26 | 广州远想生物科技有限公司 | Cosmetic or skin care product preparation rich in growth factors and preparation method therefor |
| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
| CN105194719A (en) * | 2015-10-28 | 2015-12-30 | 成都清科生物科技有限公司 | Facial wound restoration dressing and plaster, and preparation methods thereof |
| CN105233270A (en) * | 2015-11-12 | 2016-01-13 | 上海昊海生物科技股份有限公司 | Medicine composition for water-optical treatment and application of medicine composition |
| CN107260636A (en) * | 2017-07-20 | 2017-10-20 | 山东彩娜菲诗生物科技有限公司 | A kind of shin moisturizer and preparation method thereof |
-
2018
- 2018-05-24 CN CN201810505270.6A patent/CN108653790A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104080438A (en) * | 2011-11-30 | 2014-10-01 | 味之素株式会社 | Whitening cosmetic |
| CN204072471U (en) * | 2014-06-20 | 2015-01-07 | 唐山市博世德医疗器械有限公司 | A kind of Silica hydrogel scar plaster |
| CN104856892A (en) * | 2014-11-14 | 2015-08-26 | 广州远想生物科技有限公司 | Cosmetic or skin care product preparation rich in growth factors and preparation method therefor |
| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
| CN105194719A (en) * | 2015-10-28 | 2015-12-30 | 成都清科生物科技有限公司 | Facial wound restoration dressing and plaster, and preparation methods thereof |
| CN105233270A (en) * | 2015-11-12 | 2016-01-13 | 上海昊海生物科技股份有限公司 | Medicine composition for water-optical treatment and application of medicine composition |
| CN107260636A (en) * | 2017-07-20 | 2017-10-20 | 山东彩娜菲诗生物科技有限公司 | A kind of shin moisturizer and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743921A (en) * | 2018-05-24 | 2018-11-06 | 广州芬森医学科技有限公司 | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed |
| CN109453411A (en) * | 2018-12-03 | 2019-03-12 | 广州润虹医药科技股份有限公司 | A kind of chitosan dressing |
| CN109731126A (en) * | 2019-01-25 | 2019-05-10 | 芬森健康科技(广州)中心(有限合伙) | A kind of biological dressing and preparation method thereof with reparation skin function |
| CN109893467A (en) * | 2019-03-20 | 2019-06-18 | 江苏朗沁科技有限公司 | A kind of preparation method of face-beautifying dressing |
| CN114306714A (en) * | 2021-12-31 | 2022-04-12 | 安徽科门生物科技有限公司 | Method for using stem cell composite biological material for skin regeneration and repair |
| CN114306714B (en) * | 2021-12-31 | 2022-08-02 | 安徽科门生物科技有限公司 | Method for preparing stem cell composite biological material for skin regeneration and repair |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108653790A (en) | A kind of biological dressing of prevention and reduction scar formation | |
| CN108578747A (en) | A kind of gradient hyaluronic acid dressing and preparation method thereof | |
| CN108686255A (en) | It is a kind of to prevent the biological dressing and preparation method thereof that scar is formed | |
| CN106822988B (en) | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch | |
| CN107375905B (en) | Medical cold compress patch for repairing skin and preparation method thereof | |
| CN108721687A (en) | A kind of compounding repairs liquid and its preparation method and application | |
| CN105662981A (en) | Dual-effect cure essence | |
| CN108743921A (en) | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed | |
| CN101648002A (en) | Medicinal composition for treating skin injury and ulcer and application thereof | |
| CN102229705A (en) | Collagen temperature-sensitive hydrogel and preparation method thereof | |
| CN101791283B (en) | Cosmetic capable of eliminating striae gravidarum and scars | |
| CN103860449B (en) | A kind of skin care with pregrant abdominal stretch marks-removing effect and preparation method thereof | |
| CN107184961A (en) | A kind of competent cell renovation agent and preparation method thereof | |
| CN107998437A (en) | Nanometer cross-linking hyaluronic acid sodium gel and its preparation method and application | |
| CN107375032A (en) | A kind of composition and preparation method for repairing skin barrier | |
| CN109731126A (en) | A kind of biological dressing and preparation method thereof with reparation skin function | |
| CN108744024A (en) | It is a kind of to compound anti-scar liquor biological dressing and preparation method thereof | |
| CN108158885A (en) | Repair composition of striae of pregnancy and its preparation method and application | |
| CN104306324A (en) | Medical collagen gel and preparation method thereof | |
| CN106344435A (en) | Skin protection cream capable of eliminating striae gravidarum | |
| CN108686260A (en) | A kind of preparation method of the anti-scar emulsion biological dressing of compounding | |
| CN105126037B (en) | A kind of ointment for treating bone fracture and injury of the extract containing natural component and preparation method thereof | |
| CN110141678A (en) | A kind of alginates physical therapy liquid dressing and preparation method thereof | |
| CN109662939A (en) | A kind of newborn composition of chest enlarge U.S., chest enlarge breast cream and preparation method thereof | |
| CN109078172A (en) | A kind of preparation and its application based on autologous tissue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181016 |
|
| RJ01 | Rejection of invention patent application after publication |