CN108686195A - It is a kind of to have effects that improve Traditional medicine bubble bath composition, preparation method and the application of acute eczema - Google Patents
It is a kind of to have effects that improve Traditional medicine bubble bath composition, preparation method and the application of acute eczema Download PDFInfo
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- CN108686195A CN108686195A CN201810955684.9A CN201810955684A CN108686195A CN 108686195 A CN108686195 A CN 108686195A CN 201810955684 A CN201810955684 A CN 201810955684A CN 108686195 A CN108686195 A CN 108686195A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/9068—Zingiber, e.g. garden ginger
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Abstract
Have effects that improve the Traditional medicine bubble bath composition of acute eczema the invention discloses a kind of, includes following components by weight:5~12 parts of 3~7 parts of folium artemisiae argyi, 1~5 part of cape jasmine, 2~7 parts of honeysuckle, 5~15 parts of lotus leaf, 12~25 parts of orange peel, 1~5 part of wrinkled giant hyssop, 2~6 parts of sophora flower, 3~9 parts of mulberry leaf, 5~15 parts of peppermint and ginger.The invention also discloses the preparation method of the Traditional medicine bubble bath composition improve with acute eczema and have effects that the Traditional medicine bubble bath composition for improving acute eczema is preparing the application improved on acute eczema drug.The present invention has effects that the Traditional medicine bubble bath composition for improving acute eczema can reduce erythematous papules quantity and itch degree on acute eczema patient body, alleviate acute eczema, also sleep with active passages through which vital energy circulates, comfortable tranquilizing the mind, antifatigue, improvement, promote immunity and other effects.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine more particularly to a kind of Traditional medicine bubbles with improvement acute eczema
Bath composition should have effects that improve the preparation method of the Traditional medicine bubble bath composition of acute eczema and its improve in preparation acute wet
Application on rash drug.
Background technology
Acute eczema, also known as atopic dermatitis are a kind of recurrent, inflammatory skin diseases, be mainly shown as it is extensive,
Erythema multiforme papule.Pruitus, drying, inflammation etc., affect the world 15%~30% children and 2%~10% at
Year people.Eczema is the skin disease caused by a variety of internal and external factors, and pathogenesis is complicated, it is considered that has relatively closely with allergy
Relationship.The drug for treating this kind of allergy of eczema includes topical steroids and immunomodulator, wherein glucocorticosteroid swashs
Though element has preferable therapeutic effect, the adverse reactions such as atrophoderma, pigmentation can be caused.
Drug generally existing disease specific aim currently used for treating acute eczema is not strong, therapeutic effect is not satisfactory, stops
After medicine easily recurrence etc. drawbacks, meanwhile, take for a long time such treatment acute eczema drug can also cause metabolic disorder, induce aggravate sense
Dye, adverse reactions, the severe patient such as tired, sleep difference can also influence the liver kidney and endocrine metabolic diseases function of patient, it is difficult to satisfaction pair
Acute eczema it is long-term, thoroughly effect a radical cure demand.
Invention content
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide one kind having improvement acute eczema work(
The Traditional medicine bubble bath composition of effect, to overcome, the specific aim for the drug generally existing for being currently used for treatment acute eczema is not strong, treats
Effect is not satisfactory, be discontinued after easily recur, take the drawbacks such as side effect is apparent for a long time.
The second object of the present invention is to provide a kind of system of the Traditional medicine bubble bath composition improve with acute eczema
Preparation Method prepares a kind of Chinese medicine bathing with improvement acute eczema by the preparation method of the Traditional medicine bubble bath composition
Composition, for alleviating acute eczema.
The third object of the present invention, which is to provide, a kind of having effects that the Traditional medicine bubble bath composition for improving acute eczema is being made
The standby application improved on acute eczema drug, by bathing, the Traditional medicine bubble bath composition plays the role of alleviating acute eczema.
An object of the present invention adopts the following technical scheme that realization:
It is a kind of to have effects that improve the Traditional medicine bubble bath composition of acute eczema, include following components by weight:Folium artemisiae argyi 3
~7 parts, 1~5 part of cape jasmine, 2~7 parts of honeysuckle, 5~15 parts of lotus leaf, 12~25 parts of orange peel, 1~5 part of wrinkled giant hyssop, 2~6 parts of sophora flower,
5~12 parts of 3~9 parts of mulberry leaf, 5~15 parts of peppermint and ginger.
Further, the folium artemisiae argyi is 4~6 parts, and the cape jasmine is 2~4 parts, and the honeysuckle is 3~6 parts, the lotus
Leaf is 9~12 parts, and the orange peel is 18~22 parts, and the wrinkled giant hyssop is 2~4 parts, and the sophora flower is 3~5 parts, and the mulberry leaf are 5
~8 parts, the peppermint is 8~12 parts, and the ginger is 7~10 parts.
Further, the folium artemisiae argyi is 5.5 parts, and the cape jasmine is 3 parts, and the honeysuckle is 4.5 parts, and the lotus leaf is 10
Part, the orange peel is 20 parts, and the wrinkled giant hyssop is 3.2 parts, and the sophora flower is 3.5 parts, and the mulberry leaf are 6 parts, and the peppermint is 10
Part, the ginger is 9 parts.
The second object of the present invention adopts the following technical scheme that realization:
A kind of preparation method of the Traditional medicine bubble bath composition improve with acute eczema, includes the following steps:
Stock:Folium artemisiae argyi, cape jasmine, gold and silver are weighed according to each group distribution ratio of Traditional medicine bubble bath composition described in any one of the above embodiments
Flower, lotus leaf, orange peel, wrinkled giant hyssop, sophora flower, mulberry leaf, peppermint and ginger crush and cross 10~40 mesh sieve;
Prepare solid-liquid blending ingredients:The honeysuckle of crushing, orange peel, wrinkled giant hyssop, sophora flower peppermint and ginger are immersed in 30~
The temperature of 2~8h in the ethanol solution of 60% (wt%), ethanol solution are 45~60 DEG C, and 70~85 DEG C are transferred to after the completion of impregnating
Under the conditions of remove ethyl alcohol, solid-liquid blending ingredients are made;
Prepare Traditional medicine bubble bath composition:The folium artemisiae argyi of crushing, cape jasmine, lotus leaf and mulberry leaf are added to above-mentioned solid-liquid mixing group
Water carries 2~4h under the conditions of being placed in 95~100 DEG C in point, filters out solid slag, and Traditional medicine bubble bath composition is made.
Further, in material preparation step, the folium artemisiae argyi, cape jasmine, honeysuckle, lotus leaf, orange peel, wrinkled giant hyssop, sophora flower, mulberry leaf,
Peppermint and ginger crush and cross 20~25 mesh sieve.
Further, in preparing solid-liquid blending ingredients step, the dosage of the ethanol solution is 300~800 parts, ethyl alcohol
For 40~45% ethyl alcohol, ethyl alcohol soaking time is 4~6h, and the temperature of ethanol solution is 52 DEG C.
Further, in preparing solid-liquid blending ingredients step, blending ingredients impregnate after the completion of be transferred to vacuum degree be-
Under the conditions of 0.05MPa, temperature are 75 DEG C, ethyl alcohol in solution is removed.
Further, in preparing Traditional medicine bubble bath composition step, water temperature raising degree is 98 DEG C, and water carries the time as 3h, and water carries
Complete mixture crosses 100~200 mesh double gauzes, and filtrate is Traditional medicine bubble bath composition.
The third object of the present invention adopts the following technical scheme that realization:
A kind of Traditional medicine bubble bath composition answering on preparing improvement acute eczema drug for having effects that improve acute eczema
With.
Compared with prior art, the beneficial effects of the present invention are:
(1) present invention is a kind of having effects that it includes several Chinese medicine material to improve the Traditional medicine bubble bath composition of acute eczema,
By means of the synergistic effect of the effective active component of conditioning unbalance to immunity of organism in several Chinese medicine material, conditioning engine body is played
The effect of immune imbalance, to make acute eczema patient before and after improvement, the erythematous papules quantity on patient body and itch journey
Degree decline is extremely notable, achievees the effect that alleviate acute eczema.In addition, should have effects that improve the Chinese medicine of acute eczema by bathing
Bathing composition also has active passages through which vital energy circulates, comfortable tranquilizing the mind, antifatigue, improvement sleep, promotion immunity and other effects.
(2) a kind of preparation method of the Traditional medicine bubble bath composition improve with acute eczema of the present invention, passes through the system
Preparation Method prepares a kind of above-mentioned Traditional medicine bubble bath composition with improvement acute eczema, which is liquid
Blending ingredients propose the extraction of two steps by ethanol solution extraction and water, fully discharge the active component in several Chinese medicine material medicine.
(3) present invention is a kind of having effects that the Traditional medicine bubble bath composition for improving acute eczema is preparing improvement acute eczema medicine
Application on object can improve acute eczema by the bathing Traditional medicine bubble bath composition, moreover it is possible to conditioning engine body immune imbalance, tool
There are active passages through which vital energy circulates, comfortable tranquilizing the mind, antifatigue, improvement sleep, promotion immunity and other effects.
Specific implementation mode
In the following, in conjunction with specific implementation mode, the present invention is described further, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
1~5 having effects that the Chinese medicine bathing for improving acute eczema combines to illustrate that the present invention is a kind of by the following examples
The preparation process of object.Folium artemisiae argyi, cape jasmine, honeysuckle, lotus leaf, orange peel, wrinkled giant hyssop, sophora flower, mulberry leaf, peppermint in Examples 1 to 5 and life
The Chinese medicine material medicine that Jiang Junwei dries.
Embodiment 1
Stock:Weigh folium artemisiae argyi 7g, cape jasmine 1g, honeysuckle 7g, lotus leaf 5g, orange peel 12g, wrinkled giant hyssop 5g, sophora flower 2g, mulberry leaf 9g,
Peppermint 15g and ginger 12g is crushed and is crossed 10 mesh sieve.
Prepare solid-liquid blending ingredients:The honeysuckle of crushing, orange peel, wrinkled giant hyssop, sophora flower peppermint and ginger are placed in glass container
In the ethanol solution that 750ml mass fractions are 60% is injected into glass container simultaneously, then glass container is transferred to thermostatted water
In bath, the water temperature of regulating thermostatic water-bath is 45 DEG C, and glass container is placed in thermostat water bath and is transferred to after maintenance constant temperature 8h
The thermostat water bath that water temperature is 70 DEG C keeps being evacuated to -0.05MPa to vial while constant temperature 2h, thus removes mixing
Most ethyl alcohol in component.
Prepare Traditional medicine bubble bath composition:The folium artemisiae argyi of crushing, cape jasmine, lotus leaf and mulberry leaf are added to the solid-liquid of above-mentioned preparation
It is stirred and evenly mixed in blending ingredients, then carries out water under the conditions of the vial for containing above-mentioned solid-liquid blending ingredients is transferred to 95 DEG C and carry
4h.After the completion of water body, the solid-liquid blending ingredients in vial are crossed into 100 mesh double gauzes, filtrate is Traditional medicine bubble bath composition.
Embodiment 2
Stock:Weigh folium artemisiae argyi 6g, cape jasmine 4g, honeysuckle 6g, lotus leaf 9g, orange peel 18g, wrinkled giant hyssop 4g, sophora flower 3g, mulberry leaf 8g,
Peppermint 8g and ginger 7g is crushed and is crossed 20 mesh sieve.
Prepare solid-liquid blending ingredients:The honeysuckle of crushing, orange peel, wrinkled giant hyssop, sophora flower peppermint and ginger are placed in glass container
In the ethanol solution that 438ml mass fractions are 40% is injected into glass container simultaneously, then glass container is transferred to thermostatted water
In bath, the water temperature of regulating thermostatic water-bath is 48 DEG C, and glass container is placed in thermostat water bath and is transferred to after maintenance constant temperature 4h
The thermostat water bath that water temperature is 72 DEG C keeps being evacuated to -0.05MPa to vial while constant temperature 2h, thus removes mixing
Most ethyl alcohol in component.
Prepare Traditional medicine bubble bath composition:The folium artemisiae argyi of crushing, cape jasmine, lotus leaf and mulberry leaf are added to the solid-liquid of above-mentioned preparation
It is stirred and evenly mixed in blending ingredients, then carries out water under the conditions of the vial for containing above-mentioned solid-liquid blending ingredients is transferred to 97 DEG C and carry
3.5h.After the completion of water body, the solid-liquid blending ingredients in vial are crossed into 120 mesh double gauzes, filtrate is Traditional medicine bubble bath composition.
Embodiment 3
Stock:Weigh folium artemisiae argyi 5.5g, cape jasmine 3g, honeysuckle 4.5g, lotus leaf 10g, orange peel 20g, wrinkled giant hyssop 3.2g, sophora flower
3.5g, mulberry leaf 6g, peppermint 10g and ginger 9g are crushed and are crossed 22 mesh sieve.
Prepare solid-liquid blending ingredients:The honeysuckle of crushing, orange peel, wrinkled giant hyssop, sophora flower peppermint and ginger are placed in glass container
In the ethanol solution that 560ml mass fractions are 40% is injected into glass container simultaneously, then glass container is transferred to thermostatted water
In bath, the water temperature of regulating thermostatic water-bath is 52 DEG C, and glass container is placed in thermostat water bath and is shifted after maintenance constant temperature 4.5h
To the thermostat water bath that water temperature is 75 DEG C, keeps being evacuated to -0.05MPa to vial while constant temperature 2h, thus remove mixed
Most ethyl alcohol in being combined point.
Prepare Traditional medicine bubble bath composition:The folium artemisiae argyi of crushing, cape jasmine, lotus leaf and mulberry leaf are added to the solid-liquid of above-mentioned preparation
It is stirred and evenly mixed in blending ingredients, then carries out water under the conditions of the vial for containing above-mentioned solid-liquid blending ingredients is transferred to 98 DEG C and carry
3h.After the completion of water body, the solid-liquid blending ingredients in vial are crossed into 150 mesh double gauzes, filtrate is Traditional medicine bubble bath composition.
Embodiment 4
Stock:Weigh folium artemisiae argyi 4g, cape jasmine 2g, honeysuckle 3g, lotus leaf 12g, orange peel 22g, wrinkled giant hyssop 2g, sophora flower 5g, mulberry leaf 5g,
Peppermint 12g and ginger 10g is crushed and is crossed 25 mesh sieve.
Prepare solid-liquid blending ingredients:The honeysuckle of crushing, orange peel, wrinkled giant hyssop, sophora flower peppermint and ginger are placed in glass container
In the ethanol solution that 693ml mass fractions are 45% is injected into glass container simultaneously, then glass container is transferred to thermostatted water
In bath, the water temperature of regulating thermostatic water-bath is 55 DEG C, and glass container is placed in thermostat water bath and is transferred to after maintenance constant temperature 6h
The thermostat water bath that water temperature is 80 DEG C keeps being evacuated to -0.02MPa to vial while constant temperature 2h, thus removes mixing
Most ethyl alcohol in component.
Prepare Traditional medicine bubble bath composition:The folium artemisiae argyi of crushing, cape jasmine, lotus leaf and mulberry leaf are added to the solid-liquid of above-mentioned preparation
It is stirred and evenly mixed in blending ingredients, then carries out water under the conditions of the vial for containing above-mentioned solid-liquid blending ingredients is transferred to 99 DEG C and carry
2.5h.After the completion of water body, the solid-liquid blending ingredients in vial are crossed into 180 mesh double gauzes, filtrate is Traditional medicine bubble bath composition.
Embodiment 5
Stock:Weigh folium artemisiae argyi 3g, cape jasmine 5g, honeysuckle 2g, lotus leaf 15g, orange peel 25g, wrinkled giant hyssop 1g, sophora flower 6g, mulberry leaf 3g,
Peppermint 5g and ginger 5g is crushed and is crossed 40 mesh sieve.
Prepare solid-liquid blending ingredients:The honeysuckle of crushing, orange peel, wrinkled giant hyssop, sophora flower peppermint and ginger are placed in glass container
In the ethanol solution that 350ml mass fractions are 30% is injected into glass container simultaneously, then glass container is transferred to thermostatted water
In bath, the water temperature of regulating thermostatic water-bath is 60 DEG C, and glass container is placed in thermostat water bath and is transferred to after maintenance constant temperature 2h
Constant temperature 2h is kept in the thermostat water bath that water temperature is 85 DEG C, thus removes the most ethyl alcohol in blending ingredients.
Prepare Traditional medicine bubble bath composition:The folium artemisiae argyi of crushing, cape jasmine, lotus leaf and mulberry leaf are added to the solid-liquid of above-mentioned preparation
It is stirred and evenly mixed in blending ingredients, then carries out water under the conditions of the vial for containing above-mentioned solid-liquid blending ingredients is transferred to 100 DEG C and carry
2h.After the completion of water body, the solid-liquid blending ingredients in vial are crossed into 200 mesh double gauzes, filtrate is Traditional medicine bubble bath composition.
Effect test one
Experimental animal:SD rats (SPF grades) 60, male and female are unlimited, 180~220g of weight, and 60 rats are randomly divided into 6
Group:Experimental group A, experimental group B, experimental group C, experimental group D, experimental group E and control group, every group 10.Animal model:Electricity consumption pushes away
It cuts and battery powered shaver removes rat abdomen hair, area is about 2cm × 3cm, and 5% 2,4- bis- is smeared in the abdomen of shaving hair removal hair
30 μ l of nitro-chlorobenzene (DNCB) sensitization for the first time.The DNCB50 μ l that third day applies 0.2% in right back shaving area carry out secondary antigen
Attack, the left symmetrical shaving area in back do not have to drug position as a contrast.It is later primary every excitation in 3 days, continuously three times.In
It observes within nine days that erythema, oedema, papule, erosion or bleeding obviously occurs in the more left back in Rat Right back, shows modeling
Success.Test method:Traditional medicine bubble bath composition prepared by embodiment 1-5 one by volume 1:It is spare after 10 dilutions.From
From ten days, per daily towel, diluted dipping solution gently wipes the Rat Right back of the body 10 times in experimental group A in adhesional wetting embodiment 1, often
Diluted dipping solution gently wipes Rat Right in experimental group B and carries on the back 10 times in daily towel adhesional wetting embodiment 2, is stained with per daily towel
Diluted dipping solution gently wipes Rat Right in experimental group C and carries on the back 10 times in wet embodiment 3, and embodiment 4 is bedewed per daily towel
In diluted dipping solution gently wipe in experimental group D Rat Right and carry on the back 10 times, the diluted medicine in adhesional wetting embodiment 5 per daily towel
Bath solution gently wipes Rat Right in experimental group E and carries on the back 10 times, and per daily towel, adhesional wetting sterile water gently wipes rat in control group
The right back of the body 10 times.It is carried out continuously above-mentioned therapeutic process two weeks, the neck that breaks after two weeks is put to death.Being cut with aseptic operation will be on the right side of rat back part
Molding bay skin (inflammation skin) and the healthy skin in left side are cut, weigh respectively.
Observe skin turgor, including skin turgor degree=inflammation skin weight-healthy skin weight, inhibiting rate=(inflammation
Skin weight-healthy skin weight)/healthy skin weight × 100%.Skin turgor degree and inhibiting rate the results are shown in Table 1.
Reference literature"The influence that purslane extract expresses acute eczema rat skin TNF-α and IL-4", to upper
It states inflammation skin and TNF-α and the content of IL-4 is detected by immunohistochemistry, inspection the results are shown in Table 2.
Table 1
Note:* indicates experimental group compared with the control group compared with difference extremely significantly (P<0.01).
As shown in Table 1, the skin turgor degree pole of rat is substantially less than control group in experimental group A-E, and inhibiting rate is also apparent low
In control group, shows that Traditional medicine bubble bath composition prepared by embodiment 1-5 can be used in improving acute eczema, improve skin after two weeks
Swelling restores apparent, and inhibition is preferable, can preferably be restored to healthy skin state.Wherein, the Chinese medicine that prepared by embodiment 3
Bathing composition best results in terms of improving acute eczema.
Table 2
Note:* indicates experimental group compared with the control group compared with difference extremely significantly (P<0.01).
As shown in Table 2, the skin turgor degree pole of rat is substantially less than control group in experimental group A-E, shows embodiment 1-5 systems
Standby Traditional medicine bubble bath composition extremely can significantly lower TNF-α and the level of IL-4 in rat body, i.e., inflammation is anti-in rat body
It is deserved with alleviate.
Effect test two
Acute eczema patient data:Random storage is diagnosed as acute eczema patient 30 and is used as research object, meets"Skin
Skin venereology"In the diagnostic criteria in relation to acute eczema.The age distribution of 30 patients is 6~49 (25.2 ± 18.1), wherein
Male patient 18, female patient 12 press the time sequencing number 1-30 of income outpatient service.Experimental group A includes No. 1-5, reality
Test that a group B includes No. 6-10, experimental group C includes No. 11-15, experimental group D includes No. 16-20, experimental group E includes No. 21-25, experiment
Group F packets 26-30.Age, gender and not statistically significant (the P (s > of course of disease comparing difference of 6 groups of acute eczema patients;0.05),
It is comparable.
Bathing method:Daily morning and evening prepared by each bathing embodiment 1-5 by experimental group A-E (corresponding embodiment 1-5 respectively)
Traditional medicine bubble bath composition it is one.When bathing, first by the hot water of the corresponding Traditional medicine bubble bath compositions of embodiment 1-5 and 95 DEG C or more
It is 1 according to volume ratio:10 mixing.First use liquid steam fumigating eczema infection position, etc. temperature it is suitable after again by eczema infection position
It immerses in mixed liquor, impregnates 30min.Period can dip liquid wiping by towel.If water temperature drop to 30 DEG C or less can be with
Self-heating, water temperature are adjusted according to the demand of user.Experimental group F (control group) each oral glucose cortex daily morning and evening
Hormone glucocorticoid, oral dose are that 1 tablet once, every 5mg.30 patients receive 2 months improvement phases.
Fatiguability degree of 30 acute eczema patients before and after improving is counted, specific appraisal procedure is:30 acute wet
Rash patient receives to be both required to continuously read novel 1h before and after improving, and the fatigue conditions of patient are consulted after reading.Tired journey
Degree includes:Very tired, feeling of fatigue significantly, slightly fatigue, energetic four grades.Statistical result is shown in Table 3.
Sleep state of 30 acute eczema patients before and after improving is counted, specific appraisal procedure is:Night wake up 5 times with
It upper (i.e. intermittent sleep) or is difficult to the person of falling asleep and wakes up 1- at wake up 3-4 times poor, night that is calculated as sleeping at poor, night that is calculated as sleeping
It is excellent to be calculated as that sleep is general, night sufficient uninterrupted sleep is calculated as sleeping for 2 times, totally four grades.Statistical result is shown in Table 4.
Table 3
As shown in table 4, compared to experimental group F (corresponding glucocorticoid), the Chinese medicine bathing combination prepared by experimental group A-E
Object (corresponding embodiment 1-5) can significantly improve the fatiguability situation of acute eczema patient, still energy after reading one hour
Abundant patient numbers increase, although the glucocorticoid used in comparative example 1 shows certain improvement acute eczema patient's
The effect of fatiguability situation, but improve the effect for being apt to the fatiguability situation of acute eczema patient not as good as prepared by embodiment 1-5
Traditional medicine bubble bath composition.
Table 4
As shown in table 3, compared to experimental group F (corresponding contrast groups), prepared by experimental group A-E (corresponding embodiment 1-5)
Traditional medicine bubble bath composition can significantly improve the sleep state of acute eczema patient, and the patient's increase for reaching excellent situation of sleeping is bright
Aobvious, although the glucocorticoid used in experimental group F can also improve the sleep state of acute eczema patient, improvement is not so good as
Traditional medicine bubble bath composition prepared by embodiment 1-5.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (9)
1. a kind of have effects that improve the Traditional medicine bubble bath composition of acute eczema, which is characterized in that include following by weight
Component:3~7 parts of folium artemisiae argyi, 1~5 part of cape jasmine, 2~7 parts of honeysuckle, 5~15 parts of lotus leaf, 12~25 parts of orange peel, 1~5 part of wrinkled giant hyssop,
5~12 parts of 2~6 parts of sophora flower, 3~9 parts of mulberry leaf, 5~15 parts of peppermint and ginger.
2. Traditional medicine bubble bath composition as described in claim 1, which is characterized in that the folium artemisiae argyi is 4~6 parts, and the cape jasmine is 2
~4 parts, the honeysuckle is 3~6 parts, and the lotus leaf is 9~12 parts, and the orange peel is 18~22 parts, and the wrinkled giant hyssop is 2~4
Part, the sophora flower is 3~5 parts, and the mulberry leaf are 5~8 parts, and the peppermint is 8~12 parts, and the ginger is 7~10 parts.
3. Traditional medicine bubble bath composition as described in claim 1, which is characterized in that the folium artemisiae argyi is 5.5 parts, and the cape jasmine is 3
Part, the honeysuckle is 4.5 parts, and the lotus leaf is 10 parts, and the orange peel is 20 parts, and the wrinkled giant hyssop is 3.2 parts, and the sophora flower is
3.5 parts, the mulberry leaf are 6 parts, and the peppermint is 10 parts, and the ginger is 9 parts.
4. a kind of preparation method of the Traditional medicine bubble bath composition improve with acute eczema, which is characterized in that including following
Step:
Stock:According to each group distribution ratio of claim 1-3 any one of them Traditional medicine bubble bath compositions weigh folium artemisiae argyi, cape jasmine,
Honeysuckle, lotus leaf, orange peel, wrinkled giant hyssop, sophora flower, mulberry leaf, peppermint and ginger crush and cross 10~40 mesh sieve;
Prepare solid-liquid blending ingredients:The honeysuckle of crushing, orange peel, wrinkled giant hyssop, sophora flower peppermint and ginger are immersed in 30~60%
(wt%) temperature of 2~8h in ethanol solution, ethanol solution are 45~60 DEG C, and 70~85 DEG C of conditions are transferred to after the completion of impregnating
Ethyl alcohol is removed down, and solid-liquid blending ingredients are made;
Prepare Traditional medicine bubble bath composition:The folium artemisiae argyi of crushing, cape jasmine, lotus leaf and mulberry leaf are added in above-mentioned solid-liquid blending ingredients
Water carries 2~4h under the conditions of being placed in 95~100 DEG C, filters out solid slag, and Traditional medicine bubble bath composition is made.
5. preparation method as claimed in claim 4, which is characterized in that in material preparation step, the folium artemisiae argyi, cape jasmine, honeysuckle,
Lotus leaf, orange peel, wrinkled giant hyssop, sophora flower, mulberry leaf, peppermint and ginger crush and cross 20~25 mesh sieve.
6. preparation method as claimed in claim 4, which is characterized in that in preparing solid-liquid blending ingredients step, the ethyl alcohol
The dosage of solution is 300~800 parts, the ethyl alcohol that ethyl alcohol is 40~45%, and ethyl alcohol soaking time is 4~6h, the temperature of ethanol solution
Degree is 52 DEG C.
7. preparation method as claimed in claim 6, which is characterized in that in preparing solid-liquid blending ingredients step, blending ingredients
It is -0.05MPa, under the conditions of temperature is 75 DEG C that vacuum degree is transferred to after the completion of impregnating, ethyl alcohol in removing solution.
8. preparation method as claimed in claim 4, which is characterized in that in preparing Traditional medicine bubble bath composition step, water temperature raising
Degree is 98 DEG C, and water carries the time as 3h, and water has carried mixture and crossed 100~200 mesh double gauzes, and filtrate is Traditional medicine bubble bath composition.
9. a kind of having effects that the Traditional medicine bubble bath composition for improving acute eczema is preparing the application improved on acute eczema drug.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075257A (en) * | 2019-05-30 | 2019-08-02 | 中国人民解放军西部战区总医院 | Preparation and its purposes in preparation treatment eczema drug |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004018476A (en) * | 2002-06-18 | 2004-01-22 | Healthcare Lab:Kk | Agent for scalp |
| CN103071140A (en) * | 2013-02-18 | 2013-05-01 | 沈惠萍 | Traditional Chinese medicinal composition for treating eczema |
-
2018
- 2018-08-21 CN CN201810955684.9A patent/CN108686195A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004018476A (en) * | 2002-06-18 | 2004-01-22 | Healthcare Lab:Kk | Agent for scalp |
| CN103071140A (en) * | 2013-02-18 | 2013-05-01 | 沈惠萍 | Traditional Chinese medicinal composition for treating eczema |
Non-Patent Citations (3)
| Title |
|---|
| 刘建和: "《公务员医疗保健手册》", 31 January 2013, 中国中医药出版社 * |
| 张雪梅等: "金栀洁龈含漱液治疗皮炎湿疹的疗效观察", 《中国皮肤性病学杂志》 * |
| 邹春蕾: ""夏季问题宝宝常用营养药膳和护理汇总"", 《新浪博客》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075257A (en) * | 2019-05-30 | 2019-08-02 | 中国人民解放军西部战区总医院 | Preparation and its purposes in preparation treatment eczema drug |
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