CN108686008A - One kind is for uremic pharmaceutical composition and preparation method thereof and purposes - Google Patents
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- CN108686008A CN108686008A CN201810932067.7A CN201810932067A CN108686008A CN 108686008 A CN108686008 A CN 108686008A CN 201810932067 A CN201810932067 A CN 201810932067A CN 108686008 A CN108686008 A CN 108686008A
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Abstract
The invention discloses one kind for uremic pharmaceutical composition and preparation method thereof and purposes, which includes main ingredient and adjuvant;Main ingredient includes Radix Salviae Miltiorrhizae, motherwort, monkshood, rheum officinale, coptis root, Rabdosia amethystoides;Adjuvant includes Herba Epimedii, cornus officinalis sieb et zucc, hairyvein agrimony, Eclipta prostrata, HERBA HEDYOTIS DIFFUSAE, Gorgon fruit.Main ingredient is counted in parts by weight:10~15 parts of Radix Salviae Miltiorrhizae, 10~15 parts of motherwort, 5~50 parts of monkshood, 2~30 parts of rheum officinale, 2~15 parts of coptis root, 10~50 parts of Rabdosia amethystoides.Adjuvant is counted in parts by weight:10~30 parts of Herba Epimedii, 10~50 parts of cornus officinalis sieb et zucc, 10~50 parts of hairyvein agrimony, 10~50 parts of Eclipta prostrata, 15~30 parts of HERBA HEDYOTIS DIFFUSAE, 10~30 parts of Gorgon fruit.The present invention also provides the preparation method of the pharmaceutical composition and purposes.Pharmaceutical composition provided by the invention has enriching yin and nourishing kidney, strengthening the spleen and stomach, effectively reduces creatinine, is curative for effect for treating uremia, greatly mitigates patient's pain and financial burden and other effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof and purposes, and in particular, to one kind being used for uremia
Pharmaceutical composition and preparation method thereof and purposes.
Background technology
Chronic renal failure, which refers to various kidney troubles, leads to the gradual irreversibility decline of renal function, until function loses institute
The clinical syndrome that a series of symptoms of appearance and metabolic disorder are formed, abbreviation chronic kidney hypofunction.The whole latter stage of chronic kidney hypofunction is
For it has often been said that uremia.A uremia not instead of independent disease, the clinic that the kidney trouble in various late periods is shared are comprehensive
Simulator sickness is the syndrome that chronic renal failure enters that a series of clinical manifestations occurred when the last stage eventually is formed.
Uremia is renal tissue almost fibrosis, the result for causing renal function to be lost.Existing medical technology treatment
Uremia is only treated by haemodialysis, peritoneal dialysis and kidney transplantation, and dialysis brings greatly inconvenient and pain to patient,
Kidney transplantation is even more to still suffer from the expense of great number, there is also rejection phenomenon.
Invention content
The object of the present invention is to provide a kind of pharmaceutical composition and preparation method thereof and purposes, can solve existing issue,
By clinical diagnosis and treatment compliance test result, there are enriching yin and nourishing kidney, strengthening the spleen and stomach, effectively reduce creatinine, is true for treating uremia curative effect
It cuts, greatly mitigates patient's pain and financial burden and other effects.
In order to achieve the above object, the present invention provides one kind being used for uremic pharmaceutical composition, wherein the composition
Including main ingredient and adjuvant;The main ingredient includes Radix Salviae Miltiorrhizae, motherwort, monkshood, rheum officinale, coptis root, Rabdosia amethystoides;The adjuvant includes
Herba Epimedii, cornus officinalis sieb et zucc, hairyvein agrimony, Eclipta prostrata, HERBA HEDYOTIS DIFFUSAE, Gorgon fruit.
Above-mentioned is used for uremic pharmaceutical composition, wherein the main ingredient is counted in parts by weight includes:Radix Salviae Miltiorrhizae 10~
15 parts, 10~15 parts of motherwort, 5~50 parts of monkshood, 2~30 parts of rheum officinale, 2~15 parts of coptis root, 10~50 parts of Rabdosia amethystoides.
It is above-mentioned to be used for uremic pharmaceutical composition, wherein the main ingredient includes by weight:10~15g of Radix Salviae Miltiorrhizae,
10~15g of motherwort, 5~50g of monkshood, 2~30g of rheum officinale, 2~15g of coptis root, 10~50g of Rabdosia amethystoides.
Above-mentioned is used for uremic pharmaceutical composition, wherein the adjuvant is counted in parts by weight includes:Herba Epimedii 10
~30 parts, 10~50 parts of cornus officinalis sieb et zucc, 10~50 parts of hairyvein agrimony, 10~50 parts of Eclipta prostrata, 15~30 parts of HERBA HEDYOTIS DIFFUSAE, Gorgon fruit 10~30
Part.
It is above-mentioned to be used for uremic pharmaceutical composition, wherein the adjuvant includes by weight:Herba Epimedii 10~
30g, 10~50g of cornus officinalis sieb et zucc, 10~50g of hairyvein agrimony, 10~50g of Eclipta prostrata, 15~30g of HERBA HEDYOTIS DIFFUSAE, 10~30g of Gorgon fruit.
The present invention also provides the above-mentioned preparation methods for uremic pharmaceutical composition, wherein the method
For:Weigh each drug in proportion, clean after be ground it is broken, add water decoction extraction liquid, concentration it is spare.
The above-mentioned preparation method for uremic pharmaceutical composition, wherein the broken particle size range of the grinding
For 50~60 mesh.
The above-mentioned preparation method for uremic pharmaceutical composition, wherein liquid is extracted in described adding water to cook is
Medicinal material after cleaning first is added to the distilled water that 8~10 times of medicinal material amount is added by weight, heating decocts 90~120min, mistake
Filter extraction liquid, continuously adds the distilled water of 5~6 times of dregs of a decoction amount by weight in the gained dregs of a decoction, and heating decocts 60~
80min refilters extraction liquid, and merges with the liquid extracted before, and heating is boiled, be concentrated to it is former merge liquid volume 50~
It cools to room temperature, is stirred for uniformly, gained concentrate is spare after 60% mass concentration.Preferably, gained concentrate can be packed into
Container is simultaneously sealed.
Present invention provides the purposes of pharmaceutical composition prepared by above-mentioned method, wherein the pharmaceutical composition
It is used to prepare the uremic oral preparation for the treatment of.
Provided by the present invention for haing the following advantages for uremic pharmaceutical composition and preparation method thereof and purposes:
The preparation that pharmaceutical composition provided by the present invention is a kind of short treating period, curative effect is high, is had no adverse reaction with side effect,
Have the characteristics that reasonable recipe, dosage it is few, it is significant in efficacy, have no toxic side effect, be rapidly reached effect.The pharmaceutical composition has fast
Speed reduces creatinine value, promotes comprehensive excretion of vivotoxin, protects residual renal function, repairs damage renal function until restoring completely
Normal function and other effects.
Specific implementation mode
The specific implementation mode of the present invention is further described below.
Provided by the present invention for uremic pharmaceutical composition, including main ingredient and adjuvant;Main ingredient includes Radix Salviae Miltiorrhizae, benefit mother
Grass, monkshood, rheum officinale, coptis root, Rabdosia amethystoides;Adjuvant includes Herba Epimedii, cornus officinalis sieb et zucc, hairyvein agrimony, Eclipta prostrata, HERBA HEDYOTIS DIFFUSAE, Gorgon fruit.
Wherein, Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.It is bitter in taste, it is slightly cold;The thoughts of returning home, pericardium, Liver Channel.Tool
There is the effect of promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness is calmed the nerves.Cure mainly irregular menstruation, amenorrhoea dysmenorrhoea, the stagnant abdomen of the postpartum stasis of blood
Bitterly, blood stasis is pained, epigastric pain , lumps in the chest and abdomen, traumatic injury, rheumatism bi Zheng, sore and toxic, pyreticosis agitation coma, and palpitaition is lost
It sleeps.
Motherwort is the fresh or dry aerial parts of labiate motherwort.It is bitter in taste, pungent, it is slightly cold.Return liver, the heart
Packet, bladder warp.With promoting blood circulation for regulating menstruation, inducing diuresis to remove edema, it is clearing heat and detoxicating the effect of.For irregular menstruation, dysmenorrhoea Amenorrhea, lochia is not
To the greatest extent, oedema oliguria, sore swollen toxin.
Monkshood is the processed goods of the sub- root of the ranunculaceae plant rhizome of Chinese monkshood.Acrid flavour, sweet, extremely hot in nature.It belongs to the heart, kidney, spleen channel.With return
Sun rescue it is inverse, the effect of mends fire supporing yang, eliminating cold to stop pain.It collapses for yang depletion, cold weak pulse of limb, deficiency of heart-YANG, chest impediment and cardialgia, the cold of insufficiency type spits
It rushes down, coldness and pain in the epigastrium, decline of kidney-YANG, impotence Gong Leng, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
Rheum officinale is the rhizome of polygonum rheum palmatum, Rheum tanguticum Maxim or Rheum officinale.It is bitter in taste, it trembles with fear.Return stomach, big
Intestines, Liver Channel.With the logical intestines that purge heat, the effect of removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.For real heat constipation, stagnant abdominal pain, rush down dysentery it is not well,
Jaundice with damp-heat pathogen.
Coptis root is perennial fallen leaves water plant, and summer and autumn adopt complete stool, fresh or dried, and main medicinal component is berberine.
It is bitter in taste, it trembles with fear.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.With heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating.For damp and hot feeling of fullness, vomit
Spit acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache quenches one's thirst, carbuncle swells furunculosis;
Eczema, wet sore are controlled outside, duct is suppurated.
Rabdosia amethystoides is the aerial part of labiate Rabdosia amethystoides.Acrid flavour, hardship, it is cool in nature;Return liver and kidney channel.With heat-clearing profit
It is wet, the effect of promoting blood circulation to remove blood stasis, removing toxicity for detumescence.For jaundice with damp-heat pathogen, stranguria, oedema, abscess of throat, joint pain, amenorrhoea, breast
Carbuncle, hemorrhoid, carbuncle on the back, traumatic injury, venomous snake bite.
Herba Epimedii is the cauline leaf of Berberidaceae plant Herba Epimedii, Epimedium brevicornum or Epimedium sagittatum.The pungent sweet, warm of nature and flavor.Enter
Liver and kidney channel.For mend the gate of vitality, strengthening the essence gas, strengthening the bones and muscles, tonifying kidney and strengthening yang key medicine, clinic be usually used in treat impotence in male do not lift, involuntary emission
The diseases such as premature ejaculation, urinary incontinence and female sterility.With tonifying kidney and strengthening yang, the effect of dispelling wind and eliminating dampness.Cure mainly impotence and premature ejaculation, soreness of waist leg
Bitterly, numb limb, hemiplegia, neurasthenia is forgetful, and tinnitus is dizzy.
Cornus officinalis sieb et zucc is derived from the edible root tuber of sweet potato.It is sweet in flavor, it is mild-natured.Returns spleen, kidney channel.It is weary with qi-restoratives, benefiting energy, invigorating the spleen
The effect of stomach, strong kidney yin.For curing mainly edema due to deficiency of the spleen, sore swollen toxin, dry constipation of intestines.Sweet potato is also known as pachyrhizus, sweet potato, sweet potato, sweet
Potato, sweet potato, sweet potato etc. are Convolvulaceae annual plant, are a kind of healthy food of dietotherapeutic.Sweet potato contain dietary fiber,
The kind trace element of carrotene, vitamin A, B, C, E and potassium, iron, copper, selenium, calcium etc. more than 10, nutritive value is very high, by nutrition
Family be known as the most balanced health food of nutrition.
Hairyvein agrimony is the dry aerial parts of rosaceous plant Agrimony.It is bitter in taste, puckery, it puts down;Converge to heart and liver channels.With receipts
Hemostasis is held back, the effect of stop dysentery, preventing malaria, qi-restoratives.For going out blood trouble, diarrhea, dysentery, malaria fever and chills, de-power internal lesion caused by overexertion, detoxify desinsection,
It can be with controlling under boil carbuncle swells, pruritus vulvae band.
Eclipta prostrata is the herb of dicotyledon medicine feverfew Eclipta prostrata.Because when crumpling its cauline leaf, it is seen that black
Juice flows out, so being called " eclipta ", different name is called Nanjing grass, alternanthera.Nature and flavor sweet acid, it is cool.Enter liver and kidney channel.With cool
Blood, hemostasis, kidney tonifying, the cloudy effect of benefit.For spitting blood, hemoptysis, bleeding from five sense organs or subcutaneous tissue, hematuria has blood in stool, bloody flux, knife wound bleeding, poliosis,
Diphtheria, stranguria with turbid discharge, band under, private parts is wet to itch, mouse mole.
HERBA HEDYOTIS DIFFUSAE, that is, oldenlandia diffusa is the herb of Rubiaceae plants of Hedyotis oldenlandia diffusa.It is bitter in taste, sweet, it trembles with fear;Enter
Stomach, large intestine, small intestinl channel.With clearing heat and detoxicating, carbuncle that disappears dissipating bind, effect that promoting urination and removing dampness, dampness removing are treating stranguria.For carbuncle sore tumefacting virus, pharynx
Larynx swells and ache, venomous snake bite, puckery pain of heat gonorrhea, various tumours, damp and hot oedema, jaundice, acute appendicitis, lung carbuncle, boil.
Gorgon fruit is the mature seed kernel of nymphaeaceae plant Gorgon euryale.Nature and flavor are sweet, puckery, put down;Returns spleen, kidney channel.With supplementing the kidney to control the nocturnal, invigorating the spleen
The effect of antidiarrheal, eliminating dampness and arresting leucorrhea.For emission and spermatorrhea, spleen deficiency chronic diarrhea, under.
Preferably, main ingredient is counted in parts by weight includes:10~15 parts of Radix Salviae Miltiorrhizae, 10~15 parts of motherwort, 5~50 parts of monkshood,
2~30 parts of rheum officinale, 2~15 parts of coptis root, 10~50 parts of Rabdosia amethystoides.
It is highly preferred that main ingredient includes by weight:10~15g of Radix Salviae Miltiorrhizae, 10~15g of motherwort, 5~50g of monkshood, rheum officinale 2
~30g, 2~15g of coptis root, 10~50g of Rabdosia amethystoides.
Preferably, adjuvant is counted in parts by weight includes:10~30 parts of Herba Epimedii, 10~50 parts of cornus officinalis sieb et zucc, hairyvein agrimony 10~
50 parts, 10~50 parts of Eclipta prostrata, 15~30 parts of HERBA HEDYOTIS DIFFUSAE, 10~30 parts of Gorgon fruit.
It is highly preferred that adjuvant includes by weight:10~30g of Herba Epimedii, 10~50g of cornus officinalis sieb et zucc, 10~50g of hairyvein agrimony,
10~50g of Eclipta prostrata, 15~30g of HERBA HEDYOTIS DIFFUSAE, 10~30g of Gorgon fruit.
The present invention also provides the preparation method that this is used for uremic pharmaceutical composition, this method is:It weighs in proportion
Each drug, clean after be ground it is broken, add water decoction extraction liquid, concentration it is spare.
Preferably, it is 50~60 mesh to grind broken particle size range.It is first by the medicine after cleaning to add water to cook extraction liquid
The distilled water that 8~10 times of medicinal material amount is added by weight is added in material, and heating decocts 90~120min, filters extraction liquid,
The distilled water of 5~6 times of dregs of a decoction amount by weight is continuously added in the gained dregs of a decoction, heating decocts 60~80min, refilters extraction
Liquid, and merge with the liquid extracted before, heating is boiled, after being concentrated to the former mass concentration for merging liquid volume 50~60%
It cools to room temperature, is stirred for uniformly, gained concentrate is spare.
Present invention provides the purposes of pharmaceutical composition prepared by this method, which is used to prepare treatment urine
The oral preparation of toxication.
With reference to embodiment to provided by the present invention for uremic pharmaceutical composition and preparation method thereof and purposes
It is further described.
Examples 1 to 4
Material composition proportioning prepares pharmaceutical composition shown in each embodiment difference according to the form below 1.Each raw material corresponds with phase
The national standard answered.
The list of ingredients (by weight) of 1. pharmaceutical composition of table.
| Raw material | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Radix Salviae Miltiorrhizae | 10g | 15g | 13g | 26g |
| Motherwort | 10g | 15g | 12g | 28g |
| Monkshood | 5g | 50g | 20g | 80g |
| Rheum officinale | 2g | 30g | 15g | 40g |
| Coptis root | 2g | 15g | 8g | 26g |
| Rabdosia amethystoides | 10g | 50g | 25g | 70g |
| Herba Epimedii | 10g | 30g | 15g | 40g |
| Cornus officinalis sieb et zucc | 10g | 50g | 30g | 80g |
| Hairyvein agrimony | 10g | 50g | 20g | 60g |
| Eclipta prostrata | 10g | 50g | 25g | 70g |
| HERBA HEDYOTIS DIFFUSAE | 15g | 30g | 20g | 50g |
| Gorgon fruit | 10g | 30g | 15g | 40g |
The present invention also provides the preparation methods of the pharmaceutical composition of each embodiment, and the drug of each embodiment of preparation
The purposes of composition.
The preparation method is:Each drug is weighed in the ratio of arbitrary an example in Examples 1 to 4, is ground brokenly after cleaning
Broken, it is 50~60 mesh to grind broken particle size range.Decoction extraction liquid is added water, first the medicinal material after cleaning is added by weight
It is calculated as that the distilled water of 8~10 times of medicinal material amount is added, heating decocts 90~120min, and filtering extraction liquid is relayed in the gained dregs of a decoction
The distilled water of continuous addition 5~6 times of dregs of a decoction amount by weight, heating decoct 60~80min, refilter extraction liquid, and therewith
Preceding extracted liquid merges, and heating is boiled, and is cooled to room temperature after being concentrated to the former mass concentration for merging liquid volume 50~60%,
It is stirred for uniformly, gained concentrate is spare.Preferably, gained concentrate can be packed into container and be sealed.
Present invention provides the purposes of pharmaceutical composition prepared by this method, which is used to prepare treatment urine
The oral preparation of toxication.Preferably, patient can continuously take three courses for the treatment of, be 1 month per the course for the treatment of, respectively take one sooner or later daily
It is secondary, 30~50g concentrates are taken orally every time.
Using the pharmaceutical composition prepared by various embodiments of the present invention, thousands of examples have been carried out point with uremic patient
The diagnosis and treatment based on an overall analysis of the illness and the patient's condition clinical test of type, efficient up to 88% or more, obvious effective rate reaches 73% or more, or even can reach clinic and control
More.
Provided by the present invention for uremic pharmaceutical composition and preparation method thereof and purposes, the pharmaceutical composition be through
The clinical test for having crossed many cases, to its per herbal medicine function with cure mainly and formed according to the research of modern Chinese medicine pharmacology
A kind of Chinese medicine preparation, have the characteristics that formula is scientific and reasonable, production method is simple and practicable, easy to spread, short treating period, curative effect
It is high, medical expense is low, has no adverse reaction and side effect.By clinical diagnosis and treatment compliance test result, have enriching yin and nourishing kidney, strengthening the spleen and stomach,
Effectively reduce creatinine, very big mitigation patient pain and financial burden and other effects curative for effect for treating uremia.
Although present disclosure is discussed in detail by above preferred embodiment, but it should be appreciated that above-mentioned
Description is not considered as limitation of the present invention.After those skilled in the art have read the above, for the present invention's
A variety of modifications and substitutions all will be apparent.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (9)
1. one kind being used for uremic pharmaceutical composition, which is characterized in that the composition includes main ingredient and adjuvant;The main ingredient
Including Radix Salviae Miltiorrhizae, motherwort, monkshood, rheum officinale, coptis root, Rabdosia amethystoides;The adjuvant includes Herba Epimedii, cornus officinalis sieb et zucc, hairyvein agrimony, non-irrigated lotus
Grass, HERBA HEDYOTIS DIFFUSAE, Gorgon fruit.
2. being used for uremic pharmaceutical composition as described in claim 1, which is characterized in that the main ingredient is in parts by weight
Meter includes:10~15 parts of Radix Salviae Miltiorrhizae, 10~15 parts of motherwort, 5~50 parts of monkshood, 2~30 parts of rheum officinale, 2~15 parts of coptis root, Rabdosia amethystoides
10~50 parts.
3. being used for uremic pharmaceutical composition as claimed in claim 2, which is characterized in that the main ingredient wraps by weight
Contain:10~15g of Radix Salviae Miltiorrhizae, 10~15g of motherwort, 5~50g of monkshood, 2~30g of rheum officinale, 2~15g of coptis root, 10~50g of Rabdosia amethystoides.
4. being used for uremic pharmaceutical composition as described in claim 1, which is characterized in that the adjuvant is in parts by weight
Meter includes:10~30 parts of Herba Epimedii, 10~50 parts of cornus officinalis sieb et zucc, 10~50 parts of hairyvein agrimony, 10~50 parts of Eclipta prostrata, HERBA HEDYOTIS DIFFUSAE 15~
30 parts, 10~30 parts of Gorgon fruit.
5. being used for uremic pharmaceutical composition as claimed in claim 4, which is characterized in that the adjuvant wraps by weight
Contain:10~30g of Herba Epimedii, 10~50g of cornus officinalis sieb et zucc, 10~50g of hairyvein agrimony, 10~50g of Eclipta prostrata, 15~30g of HERBA HEDYOTIS DIFFUSAE, Gorgon fruit
10~30g.
6. a kind of preparation method for uremic pharmaceutical composition as described in any one of Claims 1 to 5, special
Sign is that the method is:Weigh each drug in proportion, clean after be ground it is broken, add water decoction extraction liquid, it is dense
It contracts spare.
7. being used for the preparation method of uremic pharmaceutical composition as claimed in claim 6, which is characterized in that the grinding
Broken particle size range is 50~60 mesh.
8. being used for the preparation method of uremic pharmaceutical composition as claimed in claim 6, which is characterized in that described adds water
It is that the medicinal material after cleaning first is added to the distilled water that 8~10 times of medicinal material amount is added by weight to decoct extraction liquid, and heating is decocted
90~120min is boiled, filtering extraction liquid continuously adds the distilled water of 5~6 times of dregs of a decoction amount by weight in the gained dregs of a decoction,
Heating decocts 60~80min, refilters extraction liquid, and merge with the liquid extracted before, heating is boiled, and former conjunction is concentrated to
And cooled to room temperature after the mass concentration of liquid volume 50~60%, it is stirred for uniformly, gained concentrate is spare.
9. a kind of purposes of the pharmaceutical composition prepared method as claimed in claim 6, which is characterized in that the medicine group
It closes object and is used to prepare the uremic oral preparation for the treatment of.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104353047A (en) * | 2014-11-24 | 2015-02-18 | 时成伍 | Traditional Chinese medicine for treating nephritis |
| CN104623579A (en) * | 2013-11-11 | 2015-05-20 | 李耀华 | Traditional Chinese medicine composition for treating uremia |
| CN105770318A (en) * | 2016-03-15 | 2016-07-20 | 董济嘉 | Chinese patent medicine formula for preventing and rehabilitating uremia and preparation method thereof |
-
2018
- 2018-08-15 CN CN201810932067.7A patent/CN108686008A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623579A (en) * | 2013-11-11 | 2015-05-20 | 李耀华 | Traditional Chinese medicine composition for treating uremia |
| CN104353047A (en) * | 2014-11-24 | 2015-02-18 | 时成伍 | Traditional Chinese medicine for treating nephritis |
| CN105770318A (en) * | 2016-03-15 | 2016-07-20 | 董济嘉 | Chinese patent medicine formula for preventing and rehabilitating uremia and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郭生等: "益肾导浊活血法治疗尿毒症晚期的临床观察", 《河北医学》 * |
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Application publication date: 20181023 |
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