CN108670978A - A kind of preparation process of Lyophilized Bovine Colostrums enteric-coated microsome - Google Patents
A kind of preparation process of Lyophilized Bovine Colostrums enteric-coated microsome Download PDFInfo
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- CN108670978A CN108670978A CN201810570121.8A CN201810570121A CN108670978A CN 108670978 A CN108670978 A CN 108670978A CN 201810570121 A CN201810570121 A CN 201810570121A CN 108670978 A CN108670978 A CN 108670978A
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- bovine colostrums
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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Abstract
The invention discloses a kind of preparation processes of Lyophilized Bovine Colostrums enteric-coated microsome, are made of content and enteric film coating powder, and composition weight proportioning is in content：Lyophilized Bovine Colostrums 500g 510g；Each component weight proportion is in enteric film coating powder：Hypromellose phthalate 21.25g 22g, diethyl phthalate 3.75g 4.25g, production technology of the present invention is advanced simple, it is rapid complete that particulate form makes it absorb, its immunological regulation is given full play to, intestinal flora is adjusted, promotes gastrointestinal tract growth and development or the healing of intestinal tissue wound, anti-aging, enhancing development and other effects, is suitable for all kinds of inferior healths and postoperative crowd；It can effectively ensure that active immne protein matter is not destroyed by hydrochloric acid in gastric juice in the first freeze-dried powder of ox, ensure its effect, have and increase immunological regulation, adjust intestinal flora, promote gastrointestinal tract growth and development or the healing of intestinal tissue wound, anti-aging, enhancing development and other effects so that product health-care effect is greatly enhanced.
Description
Technical field
The present invention relates to enteric-coated microsome preparing technical field, specially a kind of preparation work of Lyophilized Bovine Colostrums enteric-coated microsome
Skill.
Background technology
It is active immne protein matter that immunity active ingredient is improved in Lyophilized Bovine Colostrums, but it is easy to by hydrochloric acid in gastric juice
It destroys and fails, therefore active immne protein matter is prevented to be to ensure that Lyophilized Bovine Colostrums by hydrochloric acid in gastric juice destruction after human body is taken
The emphasis of effect；And the method for using enteric film coating, the destruction of hydrochloric acid in gastric juice when can be taken to avoid human body.
The Lyophilized Bovine Colostrums enteric-coated microsome of the present invention is effectively guaranteed ox and is just frozen using enteric method for coating film
Active immne protein matter is not destroyed by hydrochloric acid in gastric juice in dry powder, it is ensured that its effect increases immunological regulation, adjusts enterobacteriaceae
Group promotes gastrointestinal tract growth and development or the healing of intestinal tissue wound, anti-aging, enhancing development and other effects so that production
Product health-care effect is greatly enhanced.
Invention content
The purpose of the present invention is to provide a kind of preparation processes of Lyophilized Bovine Colostrums enteric-coated microsome, to solve above-mentioned background
The problem of being proposed in technology.
To achieve the above object, the present invention provides the following technical solutions：A kind of Lyophilized Bovine Colostrums enteric-coated microsome, the intestines
Molten particle is made of content and enteric film coating powder, and the interior tolerant middle composition weight proportioning is：Lyophilized Bovine Colostrums
500g-510g；Each component weight proportion is in the enteric film coating powder：Hypromellose phthalate
21.25g-22g, diethyl phthalate 3.75g-4.25g.
Preferably, a kind of preparation process of Lyophilized Bovine Colostrums enteric-coated microsome, includes the following steps：
A, take 99% edible ethanol solution 112mL-115mL, by after the completion of proportioning hypromellose phthalate and neighbour
Diethyl phthalate is added while stirring, until all dissolvings, add purified water 112mL-115mL, stirs 20min-
After 30min, enteric film coating liquid is obtained；
B, Lyophilized Bovine Colostrums are crossed into 10 mesh sieve, Lyophilized Bovine Colostrums particle is made；
C, Lyophilized Bovine Colostrums particle is placed in coating pan, opens heating device, pot body is heated, until temperature of charge reaches in pot
At 35 DEG C -38 DEG C, prepare whitewashing；
D, adjust spray gun speed be 6mL-8mL/S, 3 ㎏ -4kg of spray gun pressure, maintain pot in temperature of charge between 35-45 DEG C,
Carry out whitewashing coating operations；
E, it is dried after whitewashing, obtains finished product Lyophilized Bovine Colostrums enteric-coated microsome.
Preferably, heating device uses dry-type thermostat in the step C.
Preferably, drying temperature is 25~30 DEG C in the step E, drying time 1-2 hour.
Compared with prior art, the beneficial effects of the invention are as follows：Production technology of the present invention is advanced simple, and particulate form makes it
Absorption is rapid complete, gives full play to its immunological regulation, adjusts intestinal flora, promotes gastrointestinal tract growth and development or intestinal tissue wound
Healing, anti-aging, enhancing development and other effects, be suitable for all kinds of inferior healths and postoperative crowd；It can effectively ensure that
Just active immne protein matter is not destroyed ox by hydrochloric acid in gastric juice in freeze-dried powder, it is ensured that its effect increases immunological regulation, adjusts
Intestinal flora promotes gastrointestinal tract growth and development or the healing of intestinal tissue wound, anti-aging, enhancing development and other effects,
So that product health-care effect is greatly enhanced.
Specific implementation mode
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
The every other embodiment that art personnel are obtained without making creative work belongs to the model that the present invention protects
It encloses.
The present invention provides the following technical solutions：A kind of Lyophilized Bovine Colostrums enteric-coated microsome, the enteric-coated microsome is by content
It is formed with enteric film coating powder, the interior tolerant middle composition weight proportioning is：Lyophilized Bovine Colostrums 500g-510g；The intestines
Each component weight proportion is in molten film coating powder：Hypromellose phthalate 21.25g-22g, phthalic acid
Diethylester 3.75g-4.25g.
Embodiment one：
Enteric-coated microsome is made of content and enteric film coating powder, and the interior tolerant middle composition weight proportioning is：Colostrum freezes
Dry powder 500g；Each component weight proportion is in the enteric film coating powder：Hypromellose phthalate 21.25g,
Diethyl phthalate 3.75g.
The preparation process of the present embodiment, includes the following steps：
A, 99% edible ethanol solution 112mL is taken, by the hypromellose phthalate and O-phthalic after the completion of proportioning
Diethyl phthalate is added while stirring, until all dissolvings, add purified water 112mL, after stirring 20min, obtains enteric film
Coating solution；
B, Lyophilized Bovine Colostrums are crossed into 10 mesh sieve, Lyophilized Bovine Colostrums particle is made；
C, Lyophilized Bovine Colostrums particle is placed in coating pan, opens heating device, pot body is heated, until temperature of charge reaches in pot
At 35 DEG C, prepare whitewashing；
D, it is 6mL/S, 3 ㎏ of spray gun pressure to adjust spray gun speed, and temperature of charge in pot is maintained to carry out whitewashing coating between 35 DEG C
Operation；
E, it is dried after whitewashing, obtains finished product Lyophilized Bovine Colostrums enteric-coated microsome.
In the present embodiment, heating device uses dry-type thermostat in step C.
In the present embodiment, drying temperature is 25 DEG C in step E, 1 hour drying time.
Embodiment two：
Enteric-coated microsome is made of content and enteric film coating powder, and the interior tolerant middle composition weight proportioning is：Colostrum freezes
Dry powder 510g；Each component weight proportion is in the enteric film coating powder：Hypromellose phthalate 22g, neighbour
Diethyl phthalate 4.25g.
The preparation process of the present embodiment, includes the following steps：
A, 99% edible ethanol solution 115mL is taken, by the hypromellose phthalate and O-phthalic after the completion of proportioning
Diethyl phthalate is added while stirring, until all dissolvings, add purified water 115mL, after stirring 30min, obtains enteric film
Coating solution；
B, Lyophilized Bovine Colostrums are crossed into 10 mesh sieve, Lyophilized Bovine Colostrums particle is made；
C, Lyophilized Bovine Colostrums particle is placed in coating pan, opens heating device, pot body is heated, until temperature of charge reaches in pot
At 38 DEG C, prepare whitewashing；
D, it is 8mL/S, spray gun pressure 4kg to adjust spray gun speed, and temperature of charge in pot is maintained to carry out whitewashing coating between 45 DEG C
Operation；
E, it is dried after whitewashing, obtains finished product Lyophilized Bovine Colostrums enteric-coated microsome.
In the present embodiment, heating device uses dry-type thermostat in step C.
In the present embodiment, drying temperature is 30 DEG C in step E, 2 hours drying times.
Embodiment three：
Enteric-coated microsome is made of content and enteric film coating powder, and the interior tolerant middle composition weight proportioning is：Colostrum freezes
Dry powder 502g；Each component weight proportion is in the enteric film coating powder：Hypromellose phthalate 21.50g,
Diethyl phthalate 3.90g.
The preparation process of the present embodiment, includes the following steps：
A, 99% edible ethanol solution 113mL is taken, by the hypromellose phthalate and O-phthalic after the completion of proportioning
Diethyl phthalate is added while stirring, until all dissolvings, add purified water 113mL, after stirring 22min, obtains enteric film
Coating solution；
B, Lyophilized Bovine Colostrums are crossed into 10 mesh sieve, Lyophilized Bovine Colostrums particle is made；
C, Lyophilized Bovine Colostrums particle is placed in coating pan, opens heating device, pot body is heated, until temperature of charge reaches in pot
At 36 DEG C, prepare whitewashing；
D, it is 7mL/S, 3 ㎏ of spray gun pressure to adjust spray gun speed, and temperature of charge in pot is maintained to carry out whitewashing coating between 38 DEG C
Operation；
E, it is dried after whitewashing, obtains finished product Lyophilized Bovine Colostrums enteric-coated microsome.
In the present embodiment, heating device uses dry-type thermostat in step C.
In the present embodiment, drying temperature is 26 DEG C in step E, 1 hour drying time.
Example IV：
Enteric-coated microsome is made of content and enteric film coating powder, and the interior tolerant middle composition weight proportioning is：Colostrum freezes
Dry powder 505g；Each component weight proportion is in the enteric film coating powder：Hypromellose phthalate 21.80g,
Diethyl phthalate 4g.
The preparation process of the present embodiment, includes the following steps：
A, 99% edible ethanol solution 114mL is taken, by the hypromellose phthalate and O-phthalic after the completion of proportioning
Diethyl phthalate is added while stirring, until all dissolvings, add purified water 114mL, after stirring 25min, obtains enteric film
Coating solution；
B, Lyophilized Bovine Colostrums are crossed into 10 mesh sieve, Lyophilized Bovine Colostrums particle is made；
C, Lyophilized Bovine Colostrums particle is placed in coating pan, opens heating device, pot body is heated, until temperature of charge reaches in pot
At 37 DEG C, prepare whitewashing；
D, it is 7mL/S, spray gun pressure 4kg to adjust spray gun speed, and temperature of charge in pot is maintained to carry out whitewashing coating between 40 DEG C
Operation；
E, it is dried after whitewashing, obtains finished product Lyophilized Bovine Colostrums enteric-coated microsome.
In the present embodiment, heating device uses dry-type thermostat in step C.
In the present embodiment, drying temperature is 28 DEG C in step E, 1 hour drying time.
Clinical case：
Perhaps certain, man, 35 years old, long campaigns IT industries usually felt that body is apprehensive over nearly one month, night hidrosis, sleep quality
Difference, poor appetite do not check the apparent cause of disease through physical examination, after learn this drug after, have the attitude having a try in arms and taken, taken
After one month, hence it is evident that feel that the state of mind is poor, appetite also improves, and continues after taking two weeks, sleep quality significantly improves.
Production technology of the present invention is advanced simple, and it is rapid complete that particulate form makes it absorb, and gives full play to its immunological regulation, adjusts
It saves intestinal flora, promote the work(such as gastrointestinal tract growth and development or the healing of intestinal tissue wound, anti-aging, enhancing development
Effect is suitable for all kinds of inferior healths and postoperative crowd；Active immne protein matter in the first freeze-dried powder of ox is can effectively ensure that
It is not destroyed by hydrochloric acid in gastric juice, it is ensured that its effect increases immunological regulation, adjusts intestinal flora, promotes gastrointestinal tract growth and development or intestines
The healing of road tissue injury, anti-aging, enhancing development and other effects so that product health-care effect is greatly enhanced.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. a kind of Lyophilized Bovine Colostrums enteric-coated microsome, it is characterised in that：The enteric-coated microsome is by content and enteric film coating
Powder forms, and the interior tolerant middle composition weight proportioning is：Lyophilized Bovine Colostrums 500g-510g；In the enteric film coating powder
Each component weight proportion is：Hypromellose phthalate 21.25g-22g, diethyl phthalate 3.75g-
4.25g。
2. a kind of preparation process of Lyophilized Bovine Colostrums enteric-coated microsome, it is characterised in that：Preparation process includes the following steps：
A, take 99% edible ethanol solution 112mL-115mL, by after the completion of proportioning hypromellose phthalate and neighbour
Diethyl phthalate is added while stirring, until all dissolvings, add purified water 112mL-115mL, stirs 20min-
After 30min, enteric film coating liquid is obtained；
B, Lyophilized Bovine Colostrums are crossed into 10 mesh sieve, Lyophilized Bovine Colostrums particle is made；
C, Lyophilized Bovine Colostrums particle is placed in coating pan, opens heating device, pot body is heated, until temperature of charge reaches in pot
At 35 DEG C -38 DEG C, prepare whitewashing；
D, adjust spray gun speed be 6mL-8mL/S, 3 ㎏ -4kg of spray gun pressure, maintain pot in temperature of charge between 35-45 DEG C,
Carry out whitewashing coating operations；
E, it is dried after whitewashing, obtains finished product Lyophilized Bovine Colostrums enteric-coated microsome.
3. a kind of preparation process of Lyophilized Bovine Colostrums enteric-coated microsome according to claim 2, it is characterised in that：The step
Heating device uses dry-type thermostat in rapid C.
4. a kind of preparation process of Lyophilized Bovine Colostrums enteric-coated microsome according to claim 2, it is characterised in that：The step
Drying temperature is 25~30 DEG C in rapid E, drying time 1-2 hour.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110999976A (en) * | 2019-12-20 | 2020-04-14 | 康道生物（南通）有限公司 | Bovine colostrum freeze-dried powder capsule and preparation process thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036633A (en) * | 2007-04-28 | 2007-09-19 | 杭州民生药业集团有限公司 | Enteric coated omeprazole pellets capsule and the preparing method thereof |
| CN101134037A (en) * | 2006-07-20 | 2008-03-05 | 杨喜鸿 | Rimonabant or the enteric-coated preparations of the rimonabant medical salts and method for preparing the same |
| CN101219152A (en) * | 2008-02-01 | 2008-07-16 | 吉林农业大学 | Immune bovine colostrum and method for preparing bifidobacteria composite tiny capsule and pill |
| CN101375849A (en) * | 2007-08-27 | 2009-03-04 | 湖南正清制药集团股份有限公司 | Novel dosage form of sinomenine medicament or hydrochlorate thereof and preparation technique thereof |
| CN104225604A (en) * | 2013-06-14 | 2014-12-24 | 信越化学工业株式会社 | Method for producing aqueous enteric coating liquid, solid preparation, and method for producing same |
| CN105707570A (en) * | 2014-12-01 | 2016-06-29 | 哈尔滨墨医生物技术有限公司 | Lumbricin protein lactobin tablet capable of enhancing immunity and production method thereof |
-
2018
- 2018-06-05 CN CN201810570121.8A patent/CN108670978A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101134037A (en) * | 2006-07-20 | 2008-03-05 | 杨喜鸿 | Rimonabant or the enteric-coated preparations of the rimonabant medical salts and method for preparing the same |
| CN101036633A (en) * | 2007-04-28 | 2007-09-19 | 杭州民生药业集团有限公司 | Enteric coated omeprazole pellets capsule and the preparing method thereof |
| CN101375849A (en) * | 2007-08-27 | 2009-03-04 | 湖南正清制药集团股份有限公司 | Novel dosage form of sinomenine medicament or hydrochlorate thereof and preparation technique thereof |
| CN101219152A (en) * | 2008-02-01 | 2008-07-16 | 吉林农业大学 | Immune bovine colostrum and method for preparing bifidobacteria composite tiny capsule and pill |
| CN104225604A (en) * | 2013-06-14 | 2014-12-24 | 信越化学工业株式会社 | Method for producing aqueous enteric coating liquid, solid preparation, and method for producing same |
| CN105707570A (en) * | 2014-12-01 | 2016-06-29 | 哈尔滨墨医生物技术有限公司 | Lumbricin protein lactobin tablet capable of enhancing immunity and production method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨柳 等: "免疫牛初乳与双歧杆菌复合微胶囊的研制", 《食品科学》 * |
| 祁荣: "肠溶包衣材料羟丙甲纤维素邻苯二甲酸酯的研究", 《中国优秀博硕士学位论文全文数据库（硕士） 医药卫生科技辑》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110999976A (en) * | 2019-12-20 | 2020-04-14 | 康道生物（南通）有限公司 | Bovine colostrum freeze-dried powder capsule and preparation process thereof |
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Application publication date: 20181019 |