CN110946841A - Multi-bacterium symbiotic probiotic capsule prepared by multilayer embedding technology - Google Patents
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Abstract
The invention discloses a multi-bacterium symbiotic probiotic capsule prepared by a multilayer embedding technology, which comprises a coating and a multi-bacterium filling medicament, wherein the multi-bacterium filling medicament consists of the following components in parts by weight: the invention relates to a preparation method of a capsule, which comprises the following steps of 32-38 parts by mass of active lactobacillus, 30-32 parts by mass of snow lotus bacteria, 23-25 parts by mass of eurotium cristatum, 50-54 parts by mass of lactose and 48-50 parts by mass of fruit powder, wherein the active lactobacillus consists of bifidobacterium, lactobacillus and lactobacillus casei, the active lactobacillus adopts active lactobacillus powder, the snow lotus bacteria adopts snow lotus bacteria freeze-dried powder, and the invention relates to the technical field of raw bacteria capsules. The multi-bacteria symbiotic probiotic capsule prepared by the multilayer embedding technology achieves the purposes of realizing symbiosis of multi-probiotics, improving the drug effect of the probiotic capsule and facilitating production and processing.
Description
Technical Field
The invention relates to the technical field of probiotic capsules, in particular to a multi-bacterium symbiotic probiotic capsule prepared by a multilayer embedding technology.
Background
Probiotics is a kind of active microorganisms beneficial to a host, and is a general term for active beneficial microorganisms which are planted in the intestinal tract and the reproductive system of a human body and can generate definite health efficacy so as to improve the micro-ecological balance of the host and play beneficial roles.
Bacteria existing in human intestinal tracts contain beneficial bacteria which are beneficial to human health and bad bacteria which are easy to induce diseases. When the total number of beneficial bacteria in the intestinal tract is more, the number of bad bacteria is relatively reduced. In addition, each person has a different constitution, different probiotics also have different characteristics, some people may be suitable for the bacteria, and some people may be suitable for other bacteria; the combination of species avoids the aforementioned differences and thus has an effect on most people, but it is understood that the combination of species is not the more species the better, but rather a suitable combination, and that the species of the combination are not antagonistic to each other and preferably have a synergistic effect.
At present, the quantity of probiotics in the probiotic capsule is less, the coating outside the capsule is dissolved by gastric juice, the probiotics inside the capsule is exposed outside and corroded by the gastric juice, and the probiotics are not easily absorbed by intestinal tracts, so that the drug effect is reduced.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a multi-bacteria symbiotic probiotic capsule prepared by a multilayer embedding technology, which solves the problems that the number of probiotics in the existing probiotic capsule is small, the coating on the outer part of the capsule is dissolved by gastric juice, the probiotics in the capsule are exposed outside and corroded by the gastric juice, and the probiotics are not easily absorbed by intestinal tracts, so that the drug effect is reduced.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a multi-bacteria symbiotic probiotic capsule prepared by a multilayer embedding technology comprises a coating and a multi-bacteria filling medicament, wherein the multi-bacteria filling medicament consists of the following components in parts by weight: 32-38 parts of active lactobacillus, 30-32 parts of saussurea involucrata, 23-25 parts of eurotium cristatum, 50-54 parts of lactose and 48-50 parts of fruit powder, wherein the active lactobacillus consists of bifidobacterium, lactobacillus and lactobacillus casei, the active lactobacillus adopts active lactobacillus powder, and the saussurea involucrata adopts saussurea involucrata freeze-dried powder.
Preferably, the optimal weight parts of the multi-bacterium filling medicament comprise the following components: 35 parts of active lactobacillus, 31 parts of saussurea involucrate, 24 parts of eurotium cristatum, 52 parts of lactose and 49 parts of fruit powder.
Preferably, the coating consists of β parts by mass of cyclodextrin 7 parts by mass and soy protein isolate 21 parts by mass.
A preparation method of a multi-bacteria symbiotic probiotic capsule prepared by multilayer embedding technology comprises the following steps:
step one, dissolving soy protein isolate in purified water, pouring the soy protein isolate into a forming mold after the soy protein isolate is fully dissolved, drying and shaping the soy protein isolate solution in the mold, and then demolding to prepare a soy protein isolate coating to form a first layer of coating;
step two, dissolving β cyclodextrin in water for dilution, and then uniformly spraying β cyclodextrin solution on the outer surface of the soy protein isolate coating through a sprayer to form a two-layer coating;
step three, simultaneously adding active lactobacillus powder and saussurea involucrate freeze-dried powder adopted by the active lactobacillus and the saussurea involucrate into a special container, then sequentially adding lactose and fruit powder into the container, adding a proper amount of purified water, and mixing and stirring uniformly by a stirrer;
step four, filtering the uniformly mixed and stirred medicament solution, filtering out the medicament which is not fully dissolved, transferring the filtrate into a drying box, drying the moisture, condensing out solid medicament, adding the solid medicament into crushing equipment, and making the solid medicament into powder with uniform particles to obtain a multi-bacterium filled medicament;
and step five, coating and fixing the coating outside the multi-bacterium filling medicament through special equipment, and encapsulating the capsule.
Preferably, the size of the soy protein isolate coating in step one is prepared according to design requirements.
Preferably, the thickness of the second β cyclodextrin coating in the second step is set to be 0.01-0.013 mm.
Preferably, the purified water is added in the third step in an amount that can completely dissolve the starting materials.
Preferably, the drying temperature of the water in the fourth step is set to be 38-43 ℃, and the sterilization treatment is carried out on the uniform equipment before filtering and drying the medicament solution, wherein the sterilization treatment time is 15-20 min.
(III) advantageous effects
The invention provides a multi-bacteria symbiotic probiotic capsule prepared by a multilayer embedding technology. The method has the following beneficial effects:
the capsule is prepared by dissolving soybean protein isolate in purified water, pouring the soybean protein isolate into a forming die after the soybean protein isolate is fully dissolved, drying and shaping the soybean protein isolate solution in the die, demoulding to prepare a soybean protein isolate coating to form a first coating, dissolving β cyclodextrin in water for dilution, uniformly spraying β cyclodextrin solution on the outer surface of the soybean protein isolate coating through a sprayer to form a second coating, adding active lactobacillus powder and saussurea involucrata bacteria freeze-dried powder into a special container, sequentially adding lactose and fruit powder into the container, adding a proper amount of purified water, uniformly mixing and stirring through a stirrer, filtering the uniformly mixed medicament solution, filtering the medicament solution with low cholesterol, transferring the filtrate into a drying box, drying the water, condensing solid medicaments, adding the solid medicaments into crushing equipment, preparing into powder with uniform particles, obtaining a multi-bacteria filling medicament, ensuring that the uniformity of the multi-bacteria coexisting probiotic coating in the capsule is adjusted, fixing the filtrate in a drying box, drying the filtrate, drying the water, condensing the solid medicaments, adding the solid medicaments into crushing equipment, preparing the powdery monosaccharide, and packaging the multi-layer probiotic capsule to obtain the capsule which can be beneficial to the enteric bacteria capsule, and further achieve the aims of achieving the purposes of preventing the intestinal tract infection, the intestinal tract, the capsule, and preventing the intestinal tract infection of the capsule, and the intestinal tract infection of the intestinal tract, and the intestinal tract.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example one
A multi-bacteria symbiotic probiotic capsule prepared by a multilayer embedding technology comprises a coating and a multi-bacteria filling medicament, wherein the multi-bacteria filling medicament consists of the following components in parts by weight: 32 parts of active lactobacillus, 30 parts of saussurea involucrate, 23 parts of eurotium cristatum, 50 parts of lactose and 48 parts of fruit powder, wherein the active lactobacillus consists of bifidobacterium, lactobacillus and lactobacillus casei, the active lactobacillus adopts active lactobacillus powder, and the saussurea involucrate adopts saussurea involucrate freeze-dried powder.
A preparation method of a multi-bacteria symbiotic probiotic capsule prepared by multilayer embedding technology comprises the following steps:
step one, dissolving soy protein isolate in purified water, pouring the soy protein isolate into a forming mold after the soy protein isolate is fully dissolved, drying and shaping the soy protein isolate solution in the mold, and then demolding to prepare a soy protein isolate coating to form a first layer of coating;
step two, dissolving β cyclodextrin in water for dilution, and then uniformly spraying β cyclodextrin solution on the outer surface of the soy protein isolate coating through a sprayer to form a two-layer coating;
step three, simultaneously adding active lactobacillus powder and saussurea involucrate freeze-dried powder adopted by the active lactobacillus and the saussurea involucrate into a special container, then sequentially adding lactose and fruit powder into the container, adding a proper amount of purified water, and mixing and stirring uniformly by a stirrer;
step four, filtering the uniformly mixed and stirred medicament solution, filtering out the medicament which is not fully dissolved, transferring the filtrate into a drying box, drying the moisture, condensing out solid medicament, adding the solid medicament into crushing equipment, and making the solid medicament into powder with uniform particles to obtain a multi-bacterium filled medicament;
and step five, coating and fixing the coating outside the multi-bacterium filling medicament through special equipment, and encapsulating the capsule.
Example two
A multi-bacteria symbiotic probiotic capsule prepared by a multilayer embedding technology comprises a coating and a multi-bacteria filling medicament, wherein the multi-bacteria filling medicament consists of the following components in parts by weight: 35 parts of active lactobacillus, 31 parts of saussurea involucrate, 24 parts of eurotium cristatum, 52 parts of lactose and 49 parts of fruit powder, wherein the active lactobacillus consists of bifidobacterium, lactobacillus and lactobacillus casei, the active lactobacillus adopts active lactobacillus powder, and the saussurea involucrate adopts saussurea involucrate freeze-dried powder.
A preparation method of a multi-bacteria symbiotic probiotic capsule prepared by multilayer embedding technology comprises the following steps:
step one, dissolving soy protein isolate in purified water, pouring the soy protein isolate into a forming mold after the soy protein isolate is fully dissolved, drying and shaping the soy protein isolate solution in the mold, and then demolding to prepare a soy protein isolate coating to form a first layer of coating;
step two, dissolving β cyclodextrin in water for dilution, and then uniformly spraying β cyclodextrin solution on the outer surface of the soy protein isolate coating through a sprayer to form a two-layer coating;
step three, simultaneously adding active lactobacillus powder and saussurea involucrate freeze-dried powder adopted by the active lactobacillus and the saussurea involucrate into a special container, then sequentially adding lactose and fruit powder into the container, adding a proper amount of purified water, and mixing and stirring uniformly by a stirrer;
step four, filtering the uniformly mixed and stirred medicament solution, filtering out the medicament which is not fully dissolved, transferring the filtrate into a drying box, drying the moisture, condensing out solid medicament, adding the solid medicament into crushing equipment, and making the solid medicament into powder with uniform particles to obtain a multi-bacterium filled medicament;
and step five, coating and fixing the coating outside the multi-bacterium filling medicament through special equipment, and encapsulating the capsule.
EXAMPLE III
A multi-bacteria symbiotic probiotic capsule prepared by a multilayer embedding technology comprises a coating and a multi-bacteria filling medicament, wherein the multi-bacteria filling medicament consists of the following components in parts by weight: 38 parts of active lactobacillus, 32 parts of saussurea involucrate, 25 parts of eurotium cristatum, 54 parts of lactose and 50 parts of fruit powder, wherein the active lactobacillus consists of bifidobacterium, lactobacillus and lactobacillus casei, the active lactobacillus adopts active lactobacillus powder, and the saussurea involucrate adopts saussurea involucrate freeze-dried powder.
A preparation method of a multi-bacteria symbiotic probiotic capsule prepared by multilayer embedding technology comprises the following steps:
step one, dissolving soy protein isolate in purified water, pouring the soy protein isolate into a forming mold after the soy protein isolate is fully dissolved, drying and shaping the soy protein isolate solution in the mold, and then demolding to prepare a soy protein isolate coating to form a first layer of coating;
step two, dissolving β cyclodextrin in water for dilution, and then uniformly spraying β cyclodextrin solution on the outer surface of the soy protein isolate coating through a sprayer to form a two-layer coating;
step three, simultaneously adding active lactobacillus powder and saussurea involucrate freeze-dried powder adopted by the active lactobacillus and the saussurea involucrate into a special container, then sequentially adding lactose and fruit powder into the container, adding a proper amount of purified water, and mixing and stirring uniformly by a stirrer;
step four, filtering the uniformly mixed and stirred medicament solution, filtering out the medicament which is not fully dissolved, transferring the filtrate into a drying box, drying the moisture, condensing out solid medicament, adding the solid medicament into crushing equipment, and making the solid medicament into powder with uniform particles to obtain a multi-bacterium filled medicament;
and step five, coating and fixing the coating outside the multi-bacterium filling medicament through special equipment, and encapsulating the capsule.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation. The use of the phrase "comprising one of the elements does not exclude the presence of other like elements in the process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The multi-bacterium symbiotic probiotic capsule prepared by the multilayer embedding technology comprises a coating and a multi-bacterium filling medicament, and is characterized in that the multi-bacterium filling medicament consists of the following components in parts by weight: 32-38 parts of active lactobacillus, 30-32 parts of saussurea involucrata, 23-25 parts of eurotium cristatum, 50-54 parts of lactose and 48-50 parts of fruit powder, wherein the active lactobacillus consists of bifidobacterium, lactobacillus and lactobacillus casei, the active lactobacillus adopts active lactobacillus powder, and the saussurea involucrata adopts saussurea involucrata freeze-dried powder.
2. The multi-bacteria symbiotic probiotic capsule prepared by the multilayer embedding technology according to claim 1, wherein the optimal weight parts of the multi-bacteria filling agent are as follows: 35 parts of active lactobacillus, 31 parts of saussurea involucrate, 24 parts of eurotium cristatum, 52 parts of lactose and 49 parts of fruit powder.
3. The multi-bacteria symbiotic probiotic capsule prepared by the multilayer embedding technology according to claim 1, characterized in that the coating consists of β parts by mass of cyclodextrin 7 and 21 parts by mass of isolated soy protein.
4. The preparation method of the multi-bacteria symbiotic probiotic capsule prepared by the multilayer embedding technology according to claim 3, characterized by comprising the following steps:
step one, dissolving soy protein isolate in purified water, pouring the soy protein isolate into a forming mold after the soy protein isolate is fully dissolved, drying and shaping the soy protein isolate solution in the mold, and then demolding to prepare a soy protein isolate coating to form a first layer of coating;
step two, dissolving β cyclodextrin in water for dilution, and then uniformly spraying β cyclodextrin solution on the outer surface of the soy protein isolate coating through a sprayer to form a two-layer coating;
step three, simultaneously adding active lactobacillus powder and saussurea involucrate freeze-dried powder adopted by the active lactobacillus and the saussurea involucrate into a special container, then sequentially adding lactose and fruit powder into the container, adding a proper amount of purified water, and mixing and stirring uniformly by a stirrer;
step four, filtering the uniformly mixed and stirred medicament solution, filtering out the medicament which is not fully dissolved, transferring the filtrate into a drying box, drying the moisture, condensing out solid medicament, adding the solid medicament into crushing equipment, and making the solid medicament into powder with uniform particles to obtain a multi-bacterium filled medicament;
and step five, coating and fixing the coating outside the multi-bacterium filling medicament through special equipment, and encapsulating the capsule.
5. The method for preparing the multi-bacteria symbiotic probiotic capsule prepared by the multilayer embedding technology according to claim 4, is characterized in that: the size of the soy protein isolate coating in step one is prepared according to design requirements.
6. The method for preparing the multi-bacteria symbiotic probiotic capsule according to the claim 4, wherein in the second step, the thickness of the two layers of β cyclodextrin coatings is set to be 0.01-0.013 mm.
7. The method for preparing the multi-bacteria symbiotic probiotic capsule prepared by the multilayer embedding technology according to claim 4, is characterized in that: and (3) adding purified water in the third step until the initial materials are completely dissolved.
8. The method for preparing the multi-bacteria symbiotic probiotic capsule prepared by the multilayer embedding technology according to claim 4, is characterized in that: in the fourth step, the drying temperature of the water is set to be 38-43 ℃, and the sterilization treatment is carried out on the uniform equipment before filtering and drying the medicament solution, wherein the sterilization treatment time is 15-20 min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112262980A (en) * | 2020-11-06 | 2021-01-26 | 汕头市培芝食品有限公司 | Preparation method of infant nutrition supplement by embedding technology |
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| CN105287649A (en) * | 2015-11-23 | 2016-02-03 | 西安木本贞生物科技有限公司 | Medical probiotics capsule |
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| CN110384239A (en) * | 2018-04-23 | 2019-10-29 | 青岛康益生物科技有限公司 | A kind of more bacterium symbiosis probiotics chewable tablets prepared by multilayer embedding techniques |
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2019
- 2019-12-23 CN CN201911340970.5A patent/CN110946841A/en active Pending
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| US5895648A (en) * | 1996-12-23 | 1999-04-20 | Sitia-Yomo S.P.A. | Composition for feed use comprising lyophilized live lactic bacteria |
| US20120263826A1 (en) * | 2011-04-15 | 2012-10-18 | Massey University | Encapsulation system for protection of probiotics during processing |
| CN105287649A (en) * | 2015-11-23 | 2016-02-03 | 西安木本贞生物科技有限公司 | Medical probiotics capsule |
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| CN110384239A (en) * | 2018-04-23 | 2019-10-29 | 青岛康益生物科技有限公司 | A kind of more bacterium symbiosis probiotics chewable tablets prepared by multilayer embedding techniques |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112262980A (en) * | 2020-11-06 | 2021-01-26 | 汕头市培芝食品有限公司 | Preparation method of infant nutrition supplement by embedding technology |
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Application publication date: 20200403 |