CN101732281A - Production process of enteric hollow capsule - Google Patents
Production process of enteric hollow capsule Download PDFInfo
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- CN101732281A CN101732281A CN201010101795A CN201010101795A CN101732281A CN 101732281 A CN101732281 A CN 101732281A CN 201010101795 A CN201010101795 A CN 201010101795A CN 201010101795 A CN201010101795 A CN 201010101795A CN 101732281 A CN101732281 A CN 101732281A
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Abstract
The invention relates to a production process of an enteric hollow capsule. The production process is characterized in that the enteric hollow capsule is formed by carrying out soling, coloring, sol dipping and drying on medicinal bone element gelatin which is used as a main raw material to obtain a gastric-soluble blank and coating and deciduating the gastric-soluble blank. The invention not only can be quickly dried and formed without generating soft and deformed capsules, but also can produce products with high surface smooth finish, small weight difference and high qualified rate.
Description
Technical field
The present invention relates to a kind of production technology of Capsules, exactly is a kind of production technology of enteric hollow capsule.
Background technology
Form preparation after the common Capsules powder charge, dissolve in the stomach after oral, absorb the back through small intestinal and bring into play drug effect.Because the part medicine has stimulation to stomach, after patient takes side effect is arranged; Also have the part medicine to meet gastric acid and easily degrade, therefore, above-mentioned this quasi drugs just is not suitable for using common Capsules preparation.Enteric hollow capsule does not dissolve under one's belt, has only just can obtain dissolving after arriving intestinal, thereby has solved the problem of the side effect and the degraded of above-mentioned medicine.In addition, enteric hollow capsule also can dissolve at small intestinal or colon position according to the demand of medicine character, can reach the directed purpose that discharges of medicine.
The enteric hollow capsule of Sheng Chaning was to dip in earlier gelatin solution to form casing play on mould in the past, and then dip in enteric coating liquid and form one deck coatings and make, because coatings thickness degree will reach 2～3 microns in accordance with regulations, therefore oven dry is shaped slowly, and fringe margin is arranged, and capsule surface is easy to generate bubble simultaneously.Be through once dipping in coating solution because of the coating bed thickness again, so the Capsules became uneven, not only capsules weight difference is big, and appears at the substandard product of disintegrate in the gastric juice easily, simultaneously because capsule surface fineness is poor, thus on capsule filler during filling medicated powder product percent of pass low.
Summary of the invention
The objective of the invention is at above-mentioned defective, it is fast to provide a kind of oven dry to be shaped to people, can not produce the capsule of distortion that feels like jelly, and produce the surface smoothness height, and weight differential is little, the production technology of the enteric hollow capsule that qualification rate is high.
The present invention it be that to adopt medicinal bone gelatin be major ingredient through colloidal sol, painted, dip in glue, the gastric solubleness blank is made in oven dry, again the gastric solubleness blank is carried out the coating rear demoulding and forms, concrete steps are as follows:
(1) it is standby ethanol and acetone to be mixed into mixed liquor, and its ethanol percentage by weight is 10～60%, and acetone is weight percentage 90～40%;
(2) by 1: 3～8 weight ratio enteric-coating material is dissolved in the above-mentioned standby mixed liquor, soaking 1～10 day after-filtration, to get coating solution standby;
(3) colloidal sol: by 1: 1～4 weight ratio gelatin is put into water and soak in changing the glue jar, temperature is 20～30 ℃, and the time is 0.5～2 hour;
(4) it is painted: after immersion is finished, to change the heating of glue jar with circulating hot water, evacuation is removed the bubble in the glue when glue temperature is 40～80 ℃, then glue is emitted and filtered from change the glue jar, add proper amount of edible pigment and opacifier in the glue after filtration, the sodium lauryl sulphate that adds glue weight 0.1～0.5% simultaneously, the back that stirs is standby;
(5) dip in glue: the glue groove is loaded onto the Capsules production line dip in glue, ON cycle water temperature controller and water circulating pump are put into the glue groove with the standby glue in above-mentioned painted back, make the interior glue circulation of glue groove unimpeded, turn over glue speed, flow unanimity in the glue groove, after debugging determines to dip in glue length capsule die is dipped in glue;
(6) oven dry: capsule die enters drying in oven after dipping in glue, makes the gastric solubleness blank;
(7) coating: the gastric solubleness blank is sent into temperature be controlled at 20～25 ℃, humidity is controlled between 40～55% coating carries out coating more than at least twice, and coating thickness is 2～2.5 microns, promptly gets enteric hollow capsule behind the demoulding;
Enteric-coating material can be acrylic resin, cellulose acetate phthalate, Hydroxypropyl Methylcellulose Phathalate, phthalic acid hydroxyalkyl methylcellulose, poly-acetic acid O-phthalic vinyl acetate, hydroxypropylmethylcellulose acetate methylcellulose, succinate or their mixture.Described opacifier is a titanium dioxide.
Effect of the present invention
The present invention since to adopt medicinal bone gelatin be major ingredient through colloidal sol, painted, dip in glue, the gastric solubleness blank is made in oven dry, again the gastric solubleness blank is carried out at least twice coating, coating thickness is 2～2.5, demoulding forms again, therefore not only oven dry is shaped soon, can not produce the capsule of distortion that feels like jelly, and produce the surface smoothness height, weight differential is little, the product that qualification rate is high.
The specific embodiment
Embodiment 1:
It is standby that ethanol and acetone are mixed into mixed liquor, and its ethanol percentage by weight is 10%, and acetone is weight percentage 90%; The 1kg hydroxypropylmethyl cellulose phthalate is dissolved in the above-mentioned standby 3kg mixed liquor, and soaking 1～10 day after-filtration, to get coating solution standby; In changing the glue jar 1kg gelatin is put into 1kg water and soak the melt into glue, temperature is 20～30 ℃, and the time is 0.5～2 hour; After immersion is finished, to change the heating of glue jar with circulating hot water, evacuation is removed the bubble in the glue when glue temperature is 40～80 ℃, then glue is emitted and filtered from change the glue jar, add proper amount of edible pigment and titanium dioxide in the glue after filtration, the sodium lauryl sulphate that adds glue weight 0.1～0.5% simultaneously, the back that stirs is standby; The glue groove is loaded onto the Capsules production line dip in glue, ON cycle water temperature controller and water circulating pump are put into the glue groove with the standby glue in above-mentioned painted back, make the interior glue circulation of glue groove unimpeded, turn over glue speed, flow unanimity in the glue groove, after debugging determines to dip in glue length capsule die is dipped in glue; Capsule die enters drying in oven after dipping in glue, makes the gastric solubleness blank; The gastric solubleness blank is sent into temperature be controlled at 20～25 ℃, humidity is controlled between 40～55% coating carries out coating more than at least twice, and coating thickness is 2～2.5 microns, promptly gets enteric hollow capsule behind the demoulding; Enteric-coating material can be acrylic resin, cellulose acetate phthalate, Hydroxypropyl Methylcellulose Phathalate, phthalic acid hydroxyalkyl methylcellulose, poly-acetic acid O-phthalic vinyl acetate, hydroxypropylmethylcellulose acetate methylcellulose, succinate or their mixture.
Embodiment 2:
It is standby that ethanol and acetone are mixed into mixed liquor, and its ethanol percentage by weight is 35%, and acetone is weight percentage 65%; The 1kg hydroxypropylmethyl cellulose phthalate is dissolved in the above-mentioned standby 5kg mixed liquor, and soaking 1～10 day after-filtration, to get coating solution standby; In changing the glue jar 1kg gelatin is put into 2.5kg water and soak the melt into glue, temperature is 20～30 ℃, and the time is 0.5～2 hour; After immersion is finished, to change the heating of glue jar with circulating hot water, evacuation is removed the bubble in the glue when glue temperature is 40～80 ℃, then glue is emitted and filtered from change the glue jar, add proper amount of edible pigment and titanium dioxide in the glue after filtration, the sodium lauryl sulphate that adds glue weight 0.1～0.5% simultaneously, the back that stirs is standby; The glue groove is loaded onto the Capsules production line dip in glue, ON cycle water temperature controller and water circulating pump are put into the glue groove with the standby glue in above-mentioned painted back, make the interior glue circulation of glue groove unimpeded, turn over glue speed, flow unanimity in the glue groove, after debugging determines to dip in glue length capsule die is dipped in glue; Capsule die enters drying in oven after dipping in glue, makes the gastric solubleness blank; The gastric solubleness blank is sent into temperature be controlled at 20～25 ℃, humidity is controlled between 40～55% coating carries out coating more than at least twice, and coating thickness is 2～2.5 microns, promptly gets enteric hollow capsule behind the demoulding; Enteric-coating material can be acrylic resin, cellulose acetate phthalate, Hydroxypropyl Methylcellulose Phathalate, phthalic acid hydroxyalkyl methylcellulose, poly-acetic acid O-phthalic vinyl acetate, hydroxypropylmethylcellulose acetate methylcellulose, succinate or their mixture.
Embodiment 3:
It is standby that ethanol and acetone are mixed into mixed liquor, and its ethanol percentage by weight is 60%, and acetone is weight percentage 40%; The 1kg hydroxypropylmethyl cellulose phthalate is dissolved in the above-mentioned standby 8kg mixed liquor, and soaking 1～10 day after-filtration, to get coating solution standby; In changing the glue jar 1kg gelatin is put into 4kg water and soak the melt into glue, temperature is 20～30 ℃, and the time is 0.5～2 hour; After immersion is finished, to change the heating of glue jar with circulating hot water, evacuation is removed the bubble in the glue when glue temperature is 40～80 ℃, then glue is emitted and filtered from change the glue jar, add proper amount of edible pigment and titanium dioxide in the glue after filtration, the sodium lauryl sulphate that adds glue weight 0.1～0.5% simultaneously, the back that stirs is standby; The glue groove is loaded onto the Capsules production line dip in glue, ON cycle water temperature controller and water circulating pump are put into the glue groove with the standby glue in above-mentioned painted back, make the interior glue circulation of glue groove unimpeded, turn over glue speed, flow unanimity in the glue groove, after debugging determines to dip in glue length capsule die is dipped in glue; Capsule die enters drying in oven after dipping in glue, makes the gastric solubleness blank; The gastric solubleness blank is sent into temperature be controlled at 20～25 ℃, humidity is controlled between 40～55% coating carries out coating more than at least twice, and coating thickness is 2～2.5 microns, promptly gets enteric hollow capsule behind the demoulding; Enteric-coating material can be acrylic resin, cellulose acetate phthalate, Hydroxypropyl Methylcellulose Phathalate, phthalic acid hydroxyalkyl methylcellulose, poly-acetic acid O-phthalic vinyl acetate, hydroxypropylmethylcellulose acetate methylcellulose, succinate or their mixture.
Claims (2)
1. the production technology of an enteric hollow capsule is characterized in that: it be that to adopt medicinal bone gelatin be major ingredient through colloidal sol, painted, dip in glue, the gastric solubleness blank is made in oven dry, again the gastric solubleness blank is carried out the coating rear demoulding and forms, concrete steps are as follows:
(1) it is standby ethanol and acetone to be mixed into mixed liquor, and its ethanol percentage by weight is 10～60%, and acetone is weight percentage 90～40%;
(2) by 1: 3～8 weight ratio enteric-coating material is dissolved in the above-mentioned standby mixed liquor, soaking 1～10 day after-filtration, to get coating solution standby;
(3) colloidal sol: by 1: 1～4 weight ratio gelatin is put into water and soak in changing the glue jar, temperature is 20～30 ℃, and the time is 0.5～2 hour;
(4) it is painted: after immersion is finished, to change the heating of glue jar with circulating hot water, evacuation is removed the bubble in the glue when glue temperature is 40～80 ℃, then glue is emitted and filtered from change the glue jar, add proper amount of edible pigment and opacifier in the glue after filtration, the sodium lauryl sulphate that adds glue weight 0.1～0.5% simultaneously, the back that stirs is standby;
(5) dip in glue: the glue groove is loaded onto the Capsules production line dip in glue, ON cycle water temperature controller and water circulating pump are put into the glue groove with the standby glue in above-mentioned painted back, make the interior glue circulation of glue groove unimpeded, turn over glue speed, flow unanimity in the glue groove, after debugging determines to dip in glue length capsule die is dipped in glue;
(6) oven dry: capsule die enters drying in oven after dipping in glue, makes the gastric solubleness blank;
(7) coating: the gastric solubleness blank is sent into temperature be controlled at 20～25 ℃, humidity is controlled between 40～55% coating carries out coating more than at least twice, and coating thickness is 2～2.5 microns, promptly gets enteric hollow capsule behind the demoulding;
2. the production technology of enteric hollow capsule according to claim 1 is characterized in that: enteric-coating material can be acrylic resin, cellulose acetate phthalate, Hydroxypropyl Methylcellulose Phathalate, phthalic acid hydroxyalkyl methylcellulose, poly-acetic acid O-phthalic vinyl acetate, hydroxypropylmethylcellulose acetate methylcellulose, succinate or their mixture.Described opacifier is a titanium dioxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010101795A CN101732281A (en) | 2010-01-26 | 2010-01-26 | Production process of enteric hollow capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010101795A CN101732281A (en) | 2010-01-26 | 2010-01-26 | Production process of enteric hollow capsule |
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| CN101732281A true CN101732281A (en) | 2010-06-16 |
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| CN201010101795A Pending CN101732281A (en) | 2010-01-26 | 2010-01-26 | Production process of enteric hollow capsule |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953816A (en) * | 2010-09-08 | 2011-01-26 | 浙江昂利康胶囊有限公司 | Medicinal hollow capsules and preparation method and manufacturing equipment thereof |
| CN103301087A (en) * | 2013-06-05 | 2013-09-18 | 绍兴康可胶囊有限公司 | Production process of enteric gelatin hollow capsules |
| CN103340838A (en) * | 2013-06-05 | 2013-10-09 | 绍兴康可胶囊有限公司 | Enteric gelatin hollow capsule |
| CN103520134A (en) * | 2013-10-29 | 2014-01-22 | 刘松林 | Duodenum targeted hollow capsules |
| CN103800303A (en) * | 2014-01-29 | 2014-05-21 | 江苏力凡胶囊有限公司 | Enteric gelatin hollow capsule and preparation method thereof |
| CN103800302A (en) * | 2012-11-09 | 2014-05-21 | 九江昂泰胶囊有限公司 | Enteric-coated hollow capsule production process |
| CN104434870A (en) * | 2014-10-27 | 2015-03-25 | 绍兴康可胶囊有限公司 | Enteric-coated gelatine empty capsules and preparation method thereof |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
-
2010
- 2010-01-26 CN CN201010101795A patent/CN101732281A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953816A (en) * | 2010-09-08 | 2011-01-26 | 浙江昂利康胶囊有限公司 | Medicinal hollow capsules and preparation method and manufacturing equipment thereof |
| CN103800302A (en) * | 2012-11-09 | 2014-05-21 | 九江昂泰胶囊有限公司 | Enteric-coated hollow capsule production process |
| CN103301087A (en) * | 2013-06-05 | 2013-09-18 | 绍兴康可胶囊有限公司 | Production process of enteric gelatin hollow capsules |
| CN103340838A (en) * | 2013-06-05 | 2013-10-09 | 绍兴康可胶囊有限公司 | Enteric gelatin hollow capsule |
| CN103520134A (en) * | 2013-10-29 | 2014-01-22 | 刘松林 | Duodenum targeted hollow capsules |
| CN103520134B (en) * | 2013-10-29 | 2015-07-22 | 刘松林 | Duodenum targeted hollow capsules |
| CN103800303A (en) * | 2014-01-29 | 2014-05-21 | 江苏力凡胶囊有限公司 | Enteric gelatin hollow capsule and preparation method thereof |
| CN104434870A (en) * | 2014-10-27 | 2015-03-25 | 绍兴康可胶囊有限公司 | Enteric-coated gelatine empty capsules and preparation method thereof |
| CN104434870B (en) * | 2014-10-27 | 2017-10-10 | 绍兴康可胶囊有限公司 | A kind of enteric gelatin hollow capsule and preparation method thereof |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
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Open date: 20100616 |