CN103800302A - Enteric-coated hollow capsule production process - Google Patents
Enteric-coated hollow capsule production process Download PDFInfo
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- CN103800302A CN103800302A CN201210444913.3A CN201210444913A CN103800302A CN 103800302 A CN103800302 A CN 103800302A CN 201210444913 A CN201210444913 A CN 201210444913A CN 103800302 A CN103800302 A CN 103800302A
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- enteric
- glue
- hollow capsule
- capsule
- gelatin
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Abstract
The invention provides an enteric-coated hollow capsule production process, and relates to a hollow capsule production process. The production process comprises: adopting a pharmaceutical gelatin as a main material, adding a plasticizer and an enteric-coated auxiliary material after gelatin dissolving, loading the obtained gelatin liquid, drying, and carrying out cutting and nesting to prepare the enteric-coated hollow capsule in one time. According to the present invention, the complex process that the gastric-dissolved blank is firstly prepared and then the gastric juice blank is coated and demolded is reduced, and the produced product has characteristics of stable quality, uniform thickness, less weight difference, accurate disintegration point and high qualification rate, and meets requirements of the national pharmacopoeia on the enteric-coated hollow capsule.
Description
Technical field
The present invention relates to a kind of production technology of Capsules, be specifically related to a kind of production technology of enteric hollow capsule.
Background technology
Current domestic enteric hollow capsule production technology is first on mould, to dip in gastric-dissolved capsule blank to form casing play, and then dips in once or secondary enteric coating liquid forms one deck coatings and makes.Because coatings thickness degree in accordance with regulations requires to reach 2-3 micron, therefore operation is loaded down with trivial details, and drying forming is slow, Capsules became uneven, capsules weight difference is large, easily appears at gastric juice disintegrate, capsule is frangible, thus on capsule filler when filling medicated powder conforming product rate low.
Summary of the invention
The object of this invention is to provide a kind of production technology of enteric hollow capsule, its steady quality, thickness is even, and weight differential is little, and disintegrate point is accurate, and qualification rate is high, and can mass automatic production.
In order to solve the existing problem of background technology, the present invention adopts following production technology:
1), by enteric adjuvant hypromellose phthalic acid fat 2g, add acetone, ethanol, that triethyl citrate is stirred to complete dissolution filter in 9:0.5:0.25 ratio is for subsequent use;
2) colloidal sol: by the weight ratio of 1:0.02:2.5, gelatin, plasticizer, 65 ℃ of hot water are put into reaction pot, start blender simultaneously, continue to be heated to temperature and reach 75 ℃, glue is all dissolved, add appropriate food coloring and opacifier.Then glue is emitted in reaction pot, and be filtered in heat-preserving container, by the weight ratio of gelatin and enteric auxiliary material liquid 1:0.25, enteric liquid is added in heat-preserving container, stir, leave standstill insulation for subsequent use;
3) dip in glue: the glue in heat-preserving container is put to gastric-dissolved capsule production line glue groove, and capsule die dips in gum forming;
4) dry: capsule die enters after drying in oven after dipping in glue, and the demoulding, otch, fit form enteric hollow capsule.
Plasticizer in described production craft step 2 is sorbitol; Opacifier is titanium oxide.
It is major ingredient that the present invention adopts pharmagel, adds plasticizer, enteric adjuvant, dips in glue, oven dry, otch, fit again and once make after colloidal sol; Not only reduce and first made gastric solubleness blank, then gastric juice blank has been carried out to the loaded down with trivial details operation that the demoulding forms after coating, and the constant product quality of producing, thickness is even, and weight differential is little, and disintegrate point is accurate, qualification rate is high, meets state-promulgated pharmacopoeia to enteric hollow capsule requirement simultaneously.
The specific embodiment:
This specific embodiment is by the following technical solutions: 200g hypromellose phthalic acid fat is added to acetone 2000ml, ethanol 40ml is stirred to completely and dissolves, add triethyl citrate 20ml, continue to be stirred to evenly, filtration is kept in hermetic container for subsequent use.In reaction pot, 1kg gelatin, 20g sorbitol, 2.5kg65 ℃ hot water are poured into, opened blender, continue reacting by heating pot laminated heat-preserving water, make glue temperature reach 75 ℃, be incubated 2 hours, after glue dissolves completely, add appropriate food coloring and opacifier, then glue emitted from reaction pot and be filtered in heat-preserving container, the weight ratio of pressing again gelatin and enteric auxiliary material liquid 1:0.25, enteric adjuvant 250g adds in heat-preserving container, stirs, build lid, leave standstill insulation for subsequent use.Glue groove is loaded onto to gastric solubleness hollow capsule production line, ON cycle water temperature controller and water circulating pump, water temperature is controlled at 53 ± 2 ℃, and glue in heat-preserving container is put into glue groove, makes in glue groove glue circulation unimpeded, turns over glue speed, flow is consistent in glue groove; Capsule die starts to dip in glue, enters in baking oven after dipping in glue, through reciprocating 6 layers of oven dry, dry the temperature inside the box and be controlled at 25 ± 2 ℃, humidity 36-50%, after dipping in glue and drying through the ingot stripper demoulding, otch, fit enteric coated capsule.
It is major ingredient that this specific embodiment adopts pharmagel, adds plasticizer, enteric adjuvant, dips in glue, oven dry, otch, fit again and once make after colloidal sol; Not only reduce and first made gastric solubleness blank, then gastric juice blank has been carried out to the loaded down with trivial details operation that the demoulding forms after coating, and the constant product quality of producing, thickness is even, and weight differential is little, and disintegrate point is accurate, qualification rate is high, meets state-promulgated pharmacopoeia to enteric hollow capsule requirement simultaneously.
Claims (3)
1. a production technology for enteric hollow capsule, is characterized in that its production technology is:
1), by enteric adjuvant hypromellose phthalic acid fat 2g, add acetone, ethanol, that triethyl citrate is stirred to complete dissolution filter in 9:0.5:0.25 ratio is for subsequent use;
2) colloidal sol: by the weight ratio of 1:0.02:2.5, gelatin, plasticizer, 65 ℃ of hot water are put into reaction pot, start blender simultaneously, continue to be heated to temperature and reach 75 ℃, glue is all dissolved, add appropriate food coloring and opacifier; Then glue is emitted in reaction pot, and be filtered in heat-preserving container, by the weight ratio of gelatin and enteric auxiliary material liquid 1:0.25, enteric liquid is added in heat-preserving container, stir, leave standstill insulation for subsequent use;
3) dip in glue: the glue in heat-preserving container is put to gastric-dissolved capsule production line glue groove, and capsule die dips in gum forming;
4) dry: capsule die enters after drying in oven after dipping in glue, and the demoulding, otch, fit form enteric hollow capsule.
2. the production technology of a kind of enteric hollow capsule according to claim 1, is characterized in that the plasticizer in described production craft step 2 is sorbitol.
3. the production technology of a kind of enteric hollow capsule according to claim 1, is characterized in that the opacifier in described production craft step 2 is titanium oxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210444913.3A CN103800302A (en) | 2012-11-09 | 2012-11-09 | Enteric-coated hollow capsule production process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210444913.3A CN103800302A (en) | 2012-11-09 | 2012-11-09 | Enteric-coated hollow capsule production process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103800302A true CN103800302A (en) | 2014-05-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210444913.3A Pending CN103800302A (en) | 2012-11-09 | 2012-11-09 | Enteric-coated hollow capsule production process |
Country Status (1)
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| CN (1) | CN103800302A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104210049A (en) * | 2014-07-08 | 2014-12-17 | 浙江越溪胶丸有限公司 | Empty capsule demolding process |
| CN112546016A (en) * | 2020-12-15 | 2021-03-26 | 浙江万里学院 | Enteric hollow cellulose capsule and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732281A (en) * | 2010-01-26 | 2010-06-16 | 安徽黄山胶囊有限公司 | Production process of enteric hollow capsule |
-
2012
- 2012-11-09 CN CN201210444913.3A patent/CN103800302A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732281A (en) * | 2010-01-26 | 2010-06-16 | 安徽黄山胶囊有限公司 | Production process of enteric hollow capsule |
Non-Patent Citations (6)
| Title |
|---|
| YOUNG-IL JEONG ET AL.: "Evaluation of an intestinal pressure-controlled colon delivery capsules prepared by a dipping method", 《JOURNAL OF CONTROLLED RELEASE》 * |
| 张冰等: "《中药不良反应概论》", 31 January 2005, 北京大学医学出版社 * |
| 沈雪梅: "《中药制剂学》", 31 May 2006, 中国医药科技出版社 * |
| 赵淑富: "肠溶胶囊", 《明胶科学与技术》 * |
| 邓铁宏等: "《药剂学》", 31 August 2011, 清华大学出版社 * |
| 黄家利: "《中药药剂学》", 31 August 2004, 科学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104210049A (en) * | 2014-07-08 | 2014-12-17 | 浙江越溪胶丸有限公司 | Empty capsule demolding process |
| CN112546016A (en) * | 2020-12-15 | 2021-03-26 | 浙江万里学院 | Enteric hollow cellulose capsule and preparation method thereof |
| CN112546016B (en) * | 2020-12-15 | 2022-04-22 | 浙江万里学院 | Enteric hollow cellulose capsule and preparation method thereof |
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Application publication date: 20140521 |
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| RJ01 | Rejection of invention patent application after publication |