CN108295037A - A kind of 3D printing stomach and intestine slow release tablet - Google Patents
A kind of 3D printing stomach and intestine slow release tablet Download PDFInfo
- Publication number
- CN108295037A CN108295037A CN201810334097.8A CN201810334097A CN108295037A CN 108295037 A CN108295037 A CN 108295037A CN 201810334097 A CN201810334097 A CN 201810334097A CN 108295037 A CN108295037 A CN 108295037A
- Authority
- CN
- China
- Prior art keywords
- printing
- stomach
- release pharmaceutical
- pharmaceutical tablet
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of 3D printing stomach and intestine slow release tablets, pass through 3D printing multilayer controlled-release pharmaceutical tablet made from printed material including 3D printer, the number of plies of the multilayer controlled-release pharmaceutical tablet is 2~7 layers, the outer layer thickness of multilayer controlled-release pharmaceutical tablet is 4~6mm, internal layer thickness is 2~7mm, a concentration of outer layer concentration that the 3D printing multilayer controlled-release pharmaceutical tablet carries medicine is low with respect to internal layer load concentration, and the 3D printing multilayer controlled-release pharmaceutical tablet carries the concentration of medicine, and outer layer is 0.35 with internal layer concentration ratio：1~0.8：1.The 3D printing stomach and intestine slow release tablet of the present invention, multilayer controlled-release pharmaceutical tablet can be according to the state of an illness differences of patient, to by the thickness and drugloading rate that change each layer, print the drugloading rate of suitable Case treatment, especially old man and children.
Description
Technical field
The present invention relates to a kind of pharmaceutical drugs, and in particular to a kind of slow release tablet.
Background technology
Controlled release preparation be that blood is made by clothing film timing, a kind of quantitative, evenly dosage form of release drug outward
Concentration is constant, to preferably play curative effect.Traditional controlled release preparation will generally pass through coating or sustained-release micro-spheres are made,
Not only complex process, and drugloading rate is low.3D printing is as a kind of novel processing and fabricating mode, in field of pharmaceutical preparations
Using having made first appearance.3D printing can be very good the process and result of control processing and fabricating to be digitized as basis.Including
Filling rate, specific surface area, homogeneous degree etc. are controlled, there are very high potentiality making controlled release fertilizer field of pharmaceutical preparations.
Invention content
Goal of the invention：In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of 3D printing stomach and intestine slow releasing medicinal
Piece, it is easy to use.
Technical solution：A kind of 3D printing stomach and intestine slow release tablet of the present invention, including 3D printer are made by printed material
3D printing multilayer controlled-release pharmaceutical tablet, the number of plies of the multilayer controlled-release pharmaceutical tablet is 2~7 layers, and the outer layer thickness of multilayer controlled-release pharmaceutical tablet is 4
~6mm, internal layer thickness are 2~7mm, and a concentration of outer layer concentration that the 3D printing multilayer controlled-release pharmaceutical tablet carries medicine carries medicine with respect to internal layer
Concentration is low, and the 3D printing multilayer controlled-release pharmaceutical tablet carries the concentration of medicine, and outer layer is 0.35 with internal layer concentration ratio：1~0.8：1.
The shape of the 3D printing multilayer controlled-release pharmaceutical tablet is crescent, hexagon or spherical shape.
The printed material be 1~3wt% hydroxypropyl methyl celluloses, 5~10wt% alginates and 0.15~
0.2wt% calcium chloride.
The printing pressure of the 3D printer is 0.6~0.8kpa, the 3D printer nozzle movement speed of pharmacy is 10~
20mm/s, 10~15 DEG C of print temperature.
The printed material is merged with medicine drug is carried by mulser.
The 3D printer is using air pressure as the printer of power.
Advantageous effect：The 3D printing stomach and intestine slow release tablet of the present invention thickness of each layer and drugloading rate from outer layer to internal layer are passed
Increase, by regulating and controlling parameter, realizes that drug controlled release, the shape of multilayer controlled-release pharmaceutical tablet of the invention can change, regulation and control are different
Surface-to-volume ratio, realize medicine controlled releasing；Patient can also select the shape liked according to personal preference simultaneously, to increase
The enthusiasm of medication, multilayer controlled-release pharmaceutical tablet of the invention is with the basic material that enteric macromolecule is printing, to avoid stomach
The loss of the not acidproof drug of damage and part, multilayer controlled-release pharmaceutical tablet of the invention can be according to the state of an illness difference of patient, to pass through
The thickness and drugloading rate for changing each layer, print the drugloading rate of suitable Case treatment, especially old man and children.
Description of the drawings
Fig. 1 is the structural diagram of the present invention.
Specific implementation mode
Technical solution of the present invention is described in detail below, but protection scope of the present invention is not limited to embodiment.
As shown in Figure 1, a kind of 3D printing stomach and intestine slow release tablet of the present invention, including 3D printer are made by printed material
3D printing multilayer controlled-release pharmaceutical tablet, the number of plies of multilayer controlled-release pharmaceutical tablet is 2~7 layers, 1 thickness of outer layer of multilayer controlled-release pharmaceutical tablet is 4~
6mm, 2 thickness of internal layer are 2~7mm, and 1 concentration of a concentration of outer layer that the 3D printing multilayer controlled-release pharmaceutical tablet carries medicine is carried with respect to internal layer 2
Concentration is low, and 3D printing multilayer controlled-release pharmaceutical tablet carries the concentration of medicine, and outer layer 1 is 0.35 with 2 concentration ratio of internal layer：1~0.8：1,3D beats
The shape for printing multilayer controlled-release pharmaceutical tablet is circle, triangle, crescent, hexagon or square, and printed material is 1~3wt% hydroxyls
The printing pressure of propyl methocel, 5~10wt% alginates and 0.15~0.2wt% calcium chloride, 3D printer is 0.6
The 3D printer nozzle movement speed of~0.8kpa, pharmacy are 10~20mm/s, 10~15 DEG C of print temperature, printed material and load
Medicine drug is merged by mulser, and 3D printer is using air pressure as the printer of power.
The 3D printing stomach and intestine slow release tablet of the present invention thickness of each layer and drugloading rate from outer layer to internal layer are incremented by, and pass through regulation and control
Parameter realizes that drug controlled release, the shape of multilayer controlled-release pharmaceutical tablet of the invention can change, regulates and controls different surface-to-volumes
Than realizing medicine controlled releasing；Patient can also select the shape liked according to personal preference simultaneously, to increase the positive of medication
Property, multilayer controlled-release pharmaceutical tablet of the invention is with the basic material that enteric macromolecule is printing, to avoid damage and the part of stomach
The loss of not acidproof drug, multilayer controlled-release pharmaceutical tablet of the invention can be according to the state of an illness differences of patient, to by changing each layer
Thickness and drugloading rate print the drugloading rate of suitable Case treatment, especially old man and children.
As above, it although the present invention has been indicated and described with reference to specific preferred embodiment, shall not be construed as pair
The limitation of invention itself.Without prejudice to the spirit and scope of the invention as defined in the appended claims, can to its
Various changes can be made in form and in details.
Claims (6)
1. a kind of 3D printing stomach and intestine slow release tablet, it is characterised in that：Pass through 3D printing made from printed material including 3D printer
Multilayer controlled-release pharmaceutical tablet, the number of plies of the multilayer controlled-release pharmaceutical tablet are 2~7 layers, outer layer (1) thickness of multilayer controlled-release pharmaceutical tablet is 4~
6mm, internal layer (2) thickness are 2~7mm, and the 3D printing multilayer controlled-release pharmaceutical tablet carries a concentration of outer layer (1) concentration of medicine with respect to internal layer
(2) it is low to carry concentration, the 3D printing multilayer controlled-release pharmaceutical tablet carries the concentration of medicine, and outer layer (1) is 0.35 with internal layer (2) concentration ratio：1
~0.8：1.
2. 3D printing stomach and intestine slow release tablet according to claim 1, it is characterised in that：The 3D printing multilayer controlled-release pharmaceutical tablet
Shape be crescent, hexagon or spherical shape.
3. 3D printing stomach and intestine slow release tablet according to claim 2, it is characterised in that：The printed material is 1~3wt%
Hydroxypropyl methyl cellulose, 5~10wt% alginates and 0.15~0.2wt% calcium chloride.
4. 3D printing stomach and intestine slow release tablet according to claim 3, it is characterised in that：The printing pressure of the 3D printer
3D printer nozzle movement speed for 0.6~0.8kpa, pharmacy is 10~20mm/s, 10~15 DEG C of print temperature.
5. 3D printing stomach and intestine slow release tablet according to claim 4, it is characterised in that：The printed material and load medicine drug
It is merged by mulser.
6. 3D printing stomach and intestine slow release tablet according to claim 5, it is characterised in that：The 3D printer is to be with air pressure
The printer of power.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810334097.8A CN108295037A (en) | 2018-04-14 | 2018-04-14 | A kind of 3D printing stomach and intestine slow release tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810334097.8A CN108295037A (en) | 2018-04-14 | 2018-04-14 | A kind of 3D printing stomach and intestine slow release tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108295037A true CN108295037A (en) | 2018-07-20 |
Family
ID=62847427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810334097.8A Withdrawn CN108295037A (en) | 2018-04-14 | 2018-04-14 | A kind of 3D printing stomach and intestine slow release tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108295037A (en) |
-
2018
- 2018-04-14 CN CN201810334097.8A patent/CN108295037A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180720 |
|
| WW01 | Invention patent application withdrawn after publication |