CN108654141B - Platelet-rich plasma preparation device - Google Patents
Platelet-rich plasma preparation device Download PDFInfo
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- CN108654141B CN108654141B CN201810583443.6A CN201810583443A CN108654141B CN 108654141 B CN108654141 B CN 108654141B CN 201810583443 A CN201810583443 A CN 201810583443A CN 108654141 B CN108654141 B CN 108654141B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0217—Separation of non-miscible liquids by centrifugal force
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Abstract
The invention relates to a preparation device of platelet-rich plasma, belonging to the field of medical instruments. The invention provides a platelet-rich plasma preparation device, which comprises: a pipe body and a pressure lever; the top end of the tube body is open and the bottom end is closed; the lower edge of the pressure lever slides along the inner wall of the tube body in a sealing way; the interior of the tube body comprises a first chamber and a second chamber; the pressure lever is a hollow lever, a pressure lever side port is arranged on the side wall of the pressure lever, and the pressure lever side port is communicated with the first cavity and the second cavity. The invention can avoid the vibration to the platelet rich plasma in the preparation process, prevent other blood components such as red blood cells and the like from being mixed into the platelet rich plasma, and reduce the operation difficulty.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a platelet-rich plasma preparation device.
Background
Blood is mainly composed of blood cells, platelets, and plasma, wherein platelets can release various growth factors to promote tissue regeneration and repair. By centrifuging the blood, the components of different specific gravities are separated into plasma, platelets and blood cells in sequence. The concentrated Platelet plasma can be separated from the plasma by a series of operations, i.e., Platelet-rich plasma (PRP). The plasma contains high-concentration platelets, and also contains high-concentration leukocytes and fibrin. Leukocytes prevent infection, and fibrin can build a three-dimensional structure required for tissue repair. A number of basic studies and clinical trials have demonstrated that PRP can significantly promote bone and soft tissue repair. Since PRP is from self, safe and effective, it has been applied to the fields of orthopedics, oral and maxillofacial surgery, plastic surgery, cosmetology, sports medicine, etc.
When platelet-rich plasma is prepared by using the conventional platelet-rich plasma preparation device, the following problems exist: the open preparation system is easily polluted by the outside; the transfer among multiple containers exists, so that the pollution and activation probability of the blood platelets is increased; the red blood cell layer removing operation is required, the operation is complicated, and the acquisition rate of the prepared platelet-rich plasma platelets is easily affected by the skill of an operator, and it is difficult to concentrate the platelets to a high concentration.
Disclosure of Invention
In view of the above analysis, the present invention aims to provide a platelet rich plasma preparation apparatus, which is used to solve the problems of insufficient quality, complex operation and insufficient safety of platelet rich plasma prepared by the existing equipment.
The purpose of the invention is mainly realized by the following technical scheme:
an embodiment of the present invention provides a platelet rich plasma preparing apparatus including: a pipe body and a pressure lever; the top end of the tube body is open and the bottom end of the tube body is closed, and the tube body comprises a first cavity and a second cavity; the lower extreme of depression bar slides along the inner wall of body is sealed, and the depression bar is the cavity pole, is equipped with the depression bar side mouth on the lateral wall of depression bar, and first cavity of depression bar side mouth intercommunication and second cavity.
In one embodiment of the invention, the preparation device is further provided with a pushing structure, and the pushing structure is arranged at the top end of the pressure rod.
In one embodiment of the invention, the compression bar further comprises an inner rod, and the inner rod is a hollow rod and is connected with the pushing structure; the inner rod is sleeved in the pressure rod and moves axially and/or circumferentially along the inner surface of the pressure rod, and the inner rod keeps a sealing state during movement; an inner rod side opening is arranged on the side wall of the pressure lever, and the position of the inner rod side opening corresponds to that of the pressure lever side opening.
In one embodiment of the invention, the pressure lever comprises a cylindrical part and an expanding part which are arranged from top to bottom, and the inner rod is sleeved in the cylindrical part; the sectional dimension of the flared portion gradually increases from top to bottom.
In one embodiment of the present invention, the tube comprises, from top to bottom: the cross-sectional size of the thick part is larger than that of the thin part;
the section size of the transition part is gradually reduced from top to bottom or the transition part is of a step diameter-changing structure.
In one embodiment of the invention, the edge of the lower end of the flared portion sealingly slides up and down along the inner wall of the thin portion.
In one embodiment of the invention, the top of the tube body is provided with an upper cover, the upper cover is connected with the tube body in a sealing way, the center of the upper cover is provided with a central hole, and the cylindrical part of the pressure rod penetrates through the central hole.
In one embodiment of the invention, the upper cover is provided with a locking structure for locking the position of the pressure rod.
In one embodiment of the invention, the outer edge of the upper cover is provided with a balance hole; the space formed by the lower surface of the upper cover and the inner side surface of the pipe body is communicated with the outside through the balance hole; the balance hole is provided with a silica gel cover.
In one embodiment of the invention, the pushing structure is provided with a vertical communication hole which is communicated with the hollow part of the pressure rod, and the communication hole is sealed by a silica gel plug.
The embodiment of the invention has the beneficial effects that:
1. the technical scheme of the invention adopts the telescopic compression bar, realizes the separation of platelet rich plasma on the upper layer of the platelet rich plasma by means of the side port of the compression bar, can adaptively adjust the expansion amount of the compression bar according to the blood consumption, improves the adaptability of the technical scheme of the invention, realizes the opening and closing of the side port of the compression bar by the inner bar, can effectively separate the platelet rich plasma, avoids the multi-container transfer of the platelet rich plasma and avoids the activation or pollution of platelets caused by the multi-container transfer operation.
2. The technical scheme of the invention keeps the tube body for containing blood relatively static, thereby avoiding the shock to the blood during operation and influencing the quality of the prepared platelet-rich plasma; the plasma is separated from top to bottom by the movement of the pressure rod, the separated platelet poor plasma is contained in the first cavity, and then the platelet rich plasma is directly obtained in the hollow structure, so that the platelet rich plasma with high concentration can be obtained, and the extraction operation is simpler and more convenient;
3. according to the technical scheme, the sealing structures are arranged at all positions in the plasma processing device, so that the pollution of the outside to the platelet-rich plasma can be effectively prevented.
In the invention, the technical schemes can be combined with each other to realize more preferable combination schemes. Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
Drawings
The drawings are only for purposes of illustrating particular embodiments and are not to be construed as limiting the invention, wherein like reference numerals are used to designate like parts throughout.
FIG. 1 is a schematic overall structure diagram of an embodiment of the present invention;
FIG. 2 is a cross-sectional view of the overall structure of an embodiment of the present invention;
FIG. 3-1 is a schematic view of a transition portion of a stepped reducing structure according to an embodiment of the present invention;
FIG. 3-2 is a schematic view of an arcuate transition portion of an embodiment of the present invention;
FIG. 4-1 is a schematic view of an inner rod rotation according to an embodiment of the present invention;
FIG. 4-2 is a schematic view of the inner rod moving up and down according to the embodiment of the present invention;
reference numerals: 10-a tube body; 101-a first chamber; 102-a second chamber; 11-thick portion; 12-a transition portion; 13-detail; 20-covering the upper cover; 21-a central hole; 30-a pressure bar; 31-a cylindrical portion; 32-flared section; 33-side port of the pressure bar; 34-an inner rod; 35-inner rod side port; 40-a push structure; 41-a handle; 42-silica gel plug; 43-communicating hole.
Detailed Description
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate preferred embodiments of the invention and together with the description, serve to explain the principles of the invention and not to limit the scope of the invention.
The embodiment of the invention provides a platelet-rich plasma preparation device, which comprises: a pipe body 10 and a pressure lever 30; the top end of the tube body 10 is open and the bottom end is closed; the lower edge of the pressure lever 30 slides along the inner wall of the tube body 10 in a sealing way; the interior of the pipe body 10 comprises a first chamber 101 and a second chamber 102, the first chamber 101 is a chamber formed by the inner wall of the pipe body 10 and the outer wall of the pressure lever, and the second chamber 102 is a chamber formed by the bottom surface of the inner side of the pipe body 10 and the inner wall of the pressure lever 30; the pressure lever 30 is a hollow lever, a pressure lever side port 33 is arranged on the side wall of the pressure lever 30, the pressure lever side port 33 is communicated with the first chamber 101 and the second chamber 102, and the number of the pressure lever side ports 33 is not limited, but the pressure lever side ports 33 are all located on the same horizontal section. When the blood pressure-reducing device is used, the pressure lever 30 is in a completely pulled-up state, the lower edge of the pressure lever 30 is separated from the inner wall of the tube body 10 at the moment, the first cavity 101 is communicated with the second cavity 102, the space formed by the lower surface of the upper cover 20 and the inner side surface of the tube body 10 is used for containing blood, after centrifugal separation and layering are carried out, the pressure lever 30 is pushed downwards, the lower edge of the pressure lever 30 is contacted with the inner wall of the tube body 10 and is sealed, the first cavity 101 and the second cavity 102 are separated, the first cavity 101 and the second cavity 102 are only communicated through the pressure lever side port 33 at the moment, platelet-rich plasma can flow into the first cavity 101 from the pressure lever side port 33 at the uppermost layer, the uppermost layer in the second cavity 102 is platelet-. In the embodiment of the invention, the platelet-rich plasma on the upper layer of the platelet-rich plasma is separated by the compression bar 30, the platelet-rich plasma in the middle of the whole separated blood is not affected, the multi-container transfer or vibration of the platelet-rich plasma is avoided, and the high concentration of the platelet-rich plasma is ensured.
The prior art can be mainly divided into three categories.
The main principle of the first prior art is as follows: the structure for containing blood is kept fixed, the blood is pushed upwards through the upper top part, so that platelet poor plasma on the upper layer of the platelet rich plasma overflows, and the platelet rich plasma is obtained. However, this type of apparatus has a disadvantage that the upward movement of the upper member causes vibration or shaking of the blood, which may mix other components in the blood into the platelet rich plasma, thereby affecting the concentration of the platelet rich plasma. According to the embodiment of the invention, the platelet poor plasma on the upper layer of the platelet rich plasma is separated in a mode of being from top to bottom, and the downward movement of the pressure rod 30 does not affect the parts except the platelet poor plasma, so that the high concentration of the platelet rich plasma is ensured.
The main principle of the second type of prior art is: two times of centrifugation are performed, and after the first centrifugation, the red blood cells in the lowermost layer of the centrifuged blood are extracted, and after the second centrifugation, the platelet-rich plasma is extracted from the lowermost layer of the centrifuged blood. However, these devices have two additional disadvantages, requiring intermediate opening of the container, increasing the likelihood of contamination of the plasma, and the stability and effectiveness of the platelet rich plasma being adversely affected by the presence of residual red blood cells during the second draw. In the embodiment of the invention, the platelet rich plasma can be directly extracted by one-time separation, so that frequent centrifugation and extraction are avoided, the possibility of contamination of the platelet rich plasma is reduced, and the platelet rich plasma directly extracted avoids red blood cells from being mixed into the platelet rich plasma, thereby ensuring the stability and effectiveness of the platelet rich plasma.
The main principle of the third type of prior art is as follows: the blood after centrifugal separation is filled into a container with a thin middle part and a thick middle part, and the blood is deeply inserted into the container by using a syringe in the container to be directly extracted. However, the devices have two disadvantages, the injector needs to be deeply drawn under the liquid level in the operation process, and the position and the posture of the injector need to be adjusted, so that platelet-rich plasma is agitated, the concentration of the platelet-rich plasma is reduced, higher requirements are provided for the operation level of operators, and the operation difficulty is higher. According to the embodiment of the invention, the upper layer of the platelet poor plasma is separated by pressing the pressing rod 30, and an operator can directly extract the platelet rich plasma in the upper layer of the rest part in the second chamber 102, so that the stirring of the platelet rich plasma is avoided, the concentration of the platelet rich plasma is ensured, and the operation difficulty is greatly simplified.
In order to further facilitate the downward pushing of the compression bar 30, the preparation device is further provided with a pushing structure 40, the pushing structure 40 is disposed at the top end of the compression bar 30, so that the compression bar 30 can be pushed downward by the pushing structure, the compression bar 30 is pushed downward, and the platelet poor plasma at the uppermost layer in the second chamber 102 overflows from the side port 33 of the compression bar into the first chamber 101. Illustratively, the pushing structure 40 may be provided as a T-shaped handle 41, the lower end of which is connected to the plunger 30.
When the blood-purifying device is used, blood needs to be contained in the tube body 10, and the whole device is subjected to centrifugal separation along with the blood so as to avoid multi-container transfer of the blood. To avoid platelet rich plasma also escaping into the first chamber 101, it is desirable that the side port 33 of the pressure bar can be opened or closed. For this purpose, in the embodiment of the present application, an inner rod 34 is further disposed inside the pressing rod 30, and the inner rod 34 is a hollow rod and is connected to the pushing structure 40; the inner rod 34 is sleeved inside the pressure rod 30 without a gap, and the inner rod 34 axially and/or circumferentially moves along the inner surface of the pressure rod 30 and keeps rotating in a sealing state during movement; an inner rod side opening 35 is arranged on the side wall of the inner rod 34, and the position of the inner rod side opening 35 corresponds to that of the pressure rod side opening 33. The inner rod side port 35 can ensure that when the inner rod side port 35 is aligned with the pressure rod side port 33, the pressure rod side port 33 is opened, the first chamber 101 is communicated with the second chamber 102, platelet poor plasma can overflow into the first chamber 101 through the inner rod side port 35 and the pressure rod side port 33, and separation is achieved. The inner rod 34 is connected with the pushing structure 40, the pushing structure 40 can independently control the inner rod 34 to rotate or move up and down or combine the two, so that the inner rod side port 35 and the compression rod side port 33 are staggered, the compression rod side port 33 is closed, the first chamber 101 and the second chamber 102 are not communicated, and platelet-rich plasma cannot overflow from the compression rod side port 33 into the first chamber 101 after the platelet-poor plasma is completely separated. Although the inner rod 34 fits within the plunger 30 without gaps, blood can still leak through the connection and the seal between the inner rod 34 and the plunger 30 helps prevent blood from leaking between the inner rod 34 and the plunger 30.
Illustratively, the inner rod 34 rotates in the pressure rod 30, in this embodiment, an annular groove is formed inside the pressure rod 30, an annular protrusion is formed on the inner rod 34, and the annular protrusion of the inner rod 34 is clamped into the annular groove, so that the inner rod 34 rotates along the circumferential direction of the annular groove, the pressure rod side port 33 is dislocated from the inner rod side port 35, and the closing of the pressure rod side port 33 is realized.
Illustratively, the inner rod 34 translates inside the pressure lever 30, in this embodiment, a longitudinal groove parallel to the axis of the pressure lever 30 is formed inside the pressure lever 30, a longitudinal protrusion parallel to the axis of the inner rod 34 is formed on the inner rod 34, and the longitudinal protrusion is clamped into the longitudinal groove, so that the inner rod 34 translates up and down along the longitudinal groove, the pressure lever side port 33 and the inner rod side port 35 are dislocated, and the closing of the pressure lever side port 33 is realized.
In order to more accurately and clearly judge whether the platelet poor plasma is completely separated, in the embodiment of the present invention, the compression bar 30 includes a cylindrical portion 31 and a flared portion 32; the cylindrical portion 31 and the flared portion 32 are arranged from top to bottom; the inner rod 34 is fitted around the cylindrical portion 31; the cross-sectional dimension of the flared portion 32 gradually increases from top to bottom. When the pressure rod 30 presses down, the blood in the second chamber 102 firstly passes through the flared part 32, passes through the cylindrical part 31 and overflows through the pressure rod side opening 33, because the section size of the flared part 32 is small at the upper part and large at the lower part, when the pressure rod 30 presses down for a small distance, the height of the liquid level rise in the cylindrical part 31 is also larger, and for the platelet-rich plasma preparation device, no matter the prior art or the embodiment of the invention, a transparent material is generally adopted, so that whether the platelet-rich plasma completely overflows into the first chamber 101 can be more visually observed.
In order to provide the first chamber 101 with sufficient space for containing the platelet poor plasma, the tube 10 of the embodiment of the present invention comprises, from top to bottom: the thick part 11, the transition part 12 and the thin part 13, wherein the cross-sectional size of the thick part 11 is larger than that of the thin part 13; the cross-sectional dimension of the transition portion 12 gradually decreases from top to bottom, or the transition portion 12 has a step diameter-changing structure. The thick portion 11 ensures that the first chamber 101 has a larger space, and the lower edge of the flared portion 32 is separated from the inner wall of the thin portion 13 of the tube 10 when the pressure rod 30 is pulled up; the transition portion 12 is used to connect the thick portion 11 and the thin portion 13, and the transition portion 12 may be a tapered surface with a uniformly changing cross-sectional size, or a step-variable structure or an arc surface.
In the embodiment of the present invention, the lower edge of the flared portion 32 of the pressure rod 30 slides up and down along the inner wall of the thin portion 13 of the tube 10, and the lower edge of the flared portion 32 of the pressure rod 30 is sealed with the inner wall of the thin portion 13 of the tube 10. In this case, the first chamber 101 is a chamber defined between the inside of the wide portion 11, the inside of the transition portion 12, the inside of the thin portion 13 above the lower edge of the flared portion 32, the outside of the flared portion 32, and the outside of the cylindrical portion 31, and the second chamber 102 is a chamber defined by the inside of the flared portion 32, the inside of the inner stem 34, the bottom surface of the inside of the pipe 10, and the inside of the thin portion 13 below the lower edge of the flared portion 32. The sealing between the lower edge of the flared portion and the thin portion 13 of the tube 10 can effectively prevent blood from infiltrating into the first chamber 101 from between the flared portion 32 and the thin portion 13 when the flared portion 32 slides.
In the embodiment of the present invention, the top of the tube 10 is provided with an upper cover 20, the upper cover 20 is connected with the tube 10 in a sealing manner, the center of the upper cover 20 is provided with a central hole 21, and the cylindrical portion 31 of the pressing rod 30 passes through the central hole 21. The upper cover 20 is used to seal the whole apparatus, the upper cover 20 is provided with a central hole 21, and the pressing rod 30 passes through the central hole 21 to move up and down.
Because the embodiment of the invention needs to contain blood in the tube body 10 when in use, the whole device carries out centrifugation along with the blood, the pressure lever 30 and the tube body 10 need to be kept relatively static during centrifugation, and the upper cover 20 is provided with a locking structure for locking the position of the pressure lever 30. For example, the locking structure may be in a form of a thread, the outer side of the pressure rod 30 is provided with a thread, the upper cover 20 is provided with a nut, the nut and the upper cover 20 are in non-fixed connection through a limiting ring, and the nut and the thread on the outer side of the pressure rod 30 are screwed tightly to realize locking; the locking structure can also adopt a clamping ring form, an annular groove is arranged on the pressure rod 30, a limiting ring is arranged on the upper cover 20, and the limiting ring is clamped into the annular groove, so that locking can be realized.
In consideration of the sealing between the cap 20 and the tube 10, when blood is injected into the tube 10, the internal air pressure makes it difficult to inject blood into the tube 10. Therefore, in the embodiment of the present invention, the outer edge of the upper cover 20 is provided with a balance hole; the space formed by the lower surface of the upper cover 20 and the inner side surface of the tube body 10 is communicated with the outside through the balance hole; the balance hole is provided with a silica gel cover. Inside and outside through balance hole intercommunication body 10, can realize the smooth injection of blood in to body 10, sealed silica gel lid can prevent inside the pollutant access device in other steps simultaneously.
When the device is used, platelet-rich plasma is obtained through the hollow structure of the compression bar 30, the pushing structure 40 is provided with the vertical communication hole 43, the communication hole 43 is communicated with the hollow part of the compression bar 30 and is used for passing through a syringe, and the communication hole 43 is sealed by the silica gel plug 42, so that not only can the plasma be prevented from being polluted by pollutants, but also the blood can be prevented from splashing when the device is used for containing blood and carrying out centrifugal separation.
Considering that in some cases, the device of the embodiment of the present invention is not made of transparent material, and thus it cannot be determined whether the platelet poor plasma on the uppermost layer has been completely separated by directly observing the form of the page, in the embodiment of the present invention, the outer side wall of the compression bar 30 is provided with a scale, and the distance that the compression bar 30 is pressed down is used to determine how much plasma flows into the first chamber 101 through the compression bar side port 33, since various components in blood are relatively fixed, the volume of the platelet poor plasma is easily obtained under the condition that the total volume of blood is known, and thus it can be determined whether the platelet poor plasma has been completely separated by the scale on the compression bar 30.
The use method of the embodiment of the invention comprises the following steps:
rotating the inner rod 34 to make the inner rod side port 35 and the pressure rod side port 33 dislocate, opening the silica gel plug 42 at the connecting hole 43 of the pushing structure 40 and the silica gel cover of the balance hole at the outer edge of the upper cover 20, pulling the pressure rod 30 upwards to separate the lower edge of the flared part 32 from the thin part 13 of the tube body 10, and injecting the extracted blood into the tube body 10 through the communicating hole 43 of the pushing structure 40 and the hollow part of the pressure rod 30;
the relative position of the compression bar 30 and the upper cover 20 is fixed through a locking structure, a silica gel plug 42 at a communicating hole 43 of the pushing structure 40 is covered, and centrifugal separation is carried out, so that blood in the tube body 10 is divided into platelet poor plasma, a leucocyte layer and a red blood cell layer;
the locking structure is released from fixing the pressure lever 30 and the upper cover 20, and the inner rod 34 is rotated to align the inner rod side opening 35 and the pressure lever side opening 33;
the pushing structure 40 is used for slowly pushing the pressing rod 30 downwards, so that the lower edge of the flared part 32 of the pressing rod 30 is contacted with the inner wall of the thin part 13 of the tube body 10, and the pressing rod 30 divides the inner space of the tube body 10 into a first chamber 101 and a second chamber 102;
the compression bar 30 is continuously and slowly pushed downwards, the layered blood gradually rises along the hollow structure of the compression bar 30, and platelet poor plasma flows into the first chamber 101 through the inner rod side port 35 and the compression bar side port 33;
directly observing the liquid level or observing scales on the pressure lever 30, stopping pushing the pressure lever 30 when the platelet poor plasma completely enters the first chamber 101, rotating the inner rod 34 to make the inner rod side port 35 and the pressure lever side port 33 dislocated, and opening the silica gel plug 42 at the communicating hole 43 of the pushing structure 40;
connecting the luer connector of the injector with the communicating hole 43 of the pushing structure 40, continuously pushing the pressure lever 30, pressing the platelet rich plasma into the injector, stopping pushing the pressure lever 30 when red blood cells appear at the injector port, and taking down the injector, wherein the injector is the high-concentration platelet rich plasma.
In summary, the embodiment of the present invention provides a platelet rich plasma preparation apparatus, which employs a telescopic compression bar, and realizes separation of platelet rich plasma from upper layer of platelet rich plasma by means of a side port of the compression bar on the compression bar, and can adaptively adjust the telescopic amount of the compression bar according to the amount of blood, so as to improve the adaptability of the technical scheme of the present invention, and realize opening and closing of the side port of the compression bar by an inner rod, so as to effectively separate platelet rich plasma, avoid multi-container transfer of platelet rich plasma, and avoid activation or pollution of platelets caused by multi-container transfer operation; the tube body for containing blood is kept relatively still, so that the quality of prepared platelet-rich plasma is prevented from being influenced by blood shock during operation; the plasma is separated from top to bottom by the movement of the pressure rod, the separated platelet poor plasma is contained in the first chamber, and then the platelet rich plasma is directly obtained in the hollow structure, so that the platelet rich plasma with high concentration can be obtained, and the extraction operation is simpler and more convenient; according to the technical scheme, the sealing structures are arranged at all positions in the plasma processing device, so that the pollution of the outside to the platelet-rich plasma can be effectively prevented.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention.
Claims (8)
1. A platelet rich plasma preparation device, said preparation device comprising: a pipe body (10) and a pressure lever (30); the top end of the tube body (10) is open and the bottom end of the tube body is closed, and the tube body (10) comprises a first chamber (101) and a second chamber (102); the lower end of the pressure lever (30) slides in a sealing manner along the inner wall of the pipe body (10), the pressure lever (30) is a hollow lever, a pressure lever side opening (33) is formed in the side wall of the pressure lever (30), and the pressure lever side opening (33) is communicated with the first cavity (101) and the second cavity (102);
the preparation device is also provided with a pushing structure (40), and the pushing structure (40) is arranged at the top end of the pressure lever (30);
depression bar (30) are including tube-shape portion (31) and flaring portion (32) that from top to bottom set up, body (10) include from top to bottom: the edge of the lower end of the flaring portion (32) slides up and down in a sealing manner along the inner wall of the thin portion (13);
an upper cover (20) is arranged at the top of the pipe body (10), and the upper cover (20) is hermetically connected with the pipe body (10);
the pushing structure (40) is provided with a vertical communicating hole (43), and the communicating hole (43) is sealed through a silica gel plug (42).
2. The device according to claim 1, characterized in that said pressure bar (30) further comprises an inner bar (34), said inner bar (34) being a hollow bar and being connected to said pushing structure (40); the inner rod (34) is sleeved in the pressure rod (30), and the inner rod (34) moves axially and/or circumferentially along the inner surface of the pressure rod (30) and keeps a sealing state during movement; an inner rod side opening (35) is formed in the side wall of the pressure rod (30), and the position of the inner rod side opening (35) corresponds to that of the pressure rod side opening (33).
3. The device according to claim 2, characterized in that said inner rod (34) is housed inside said cylindrical portion (31); the section size of flaring portion (32) from top to bottom increases gradually.
4. A device according to claim 3, characterised in that the cross-sectional dimensions of the thick portion (11) are greater than those of the thin portion (13);
the section size of transition portion (12) from top to bottom reduces gradually or transition portion (12) are step reducing structure.
5. The manufacturing apparatus according to claim 3, wherein the upper cover (20) is provided at a center thereof with a central hole (21), and the cylindrical portion (31) of the pressing rod (30) passes through the central hole (21).
6. The manufacturing apparatus according to claim 5, wherein the upper cover (20) is provided with a locking structure for locking the position of the pressing rod (30).
7. The device according to claim 6, characterized in that the outer edge of the upper cover (20) is provided with balancing holes; the space formed by the lower surface of the upper cover (20) and the inner side surface of the pipe body (10) is communicated with the outside through the balance hole; and a silica gel cover is arranged at the balance hole.
8. The manufacturing apparatus according to any one of claims 2 to 7, wherein the communication hole (43) communicates with a hollow portion of the pressing rod (30).
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| CN201810583443.6A CN108654141B (en) | 2018-06-08 | 2018-06-08 | Platelet-rich plasma preparation device |
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| CN201810583443.6A CN108654141B (en) | 2018-06-08 | 2018-06-08 | Platelet-rich plasma preparation device |
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| CN108654141B true CN108654141B (en) | 2020-08-14 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110201424A (en) * | 2019-04-22 | 2019-09-06 | 福州比华利美容医院有限公司 | Combined type blood constituent separator |
| CN111974475B (en) * | 2020-08-20 | 2021-09-21 | 四川行之智汇知识产权运营有限公司 | Blood component separator |
| CN112371198A (en) * | 2020-11-24 | 2021-02-19 | 康膝生物医疗(深圳)有限公司 | Device and method for preparing injection type autologous i-PRF |
| CN113456910A (en) * | 2021-08-12 | 2021-10-01 | 起源细胞技术(滁州)有限公司 | Platelet-rich plasma collecting and separating device adopting physical (freezing) anticoagulation |
| CN114870436A (en) * | 2022-06-21 | 2022-08-09 | 浙江保尔曼生物科技有限公司 | Platelet-rich plasma preparation device and preparation method thereof |
| CN115770414B (en) * | 2023-01-30 | 2023-07-11 | 冠昊生物科技股份有限公司 | Centrifuge tube for preparing platelet-rich plasma and centrifugation method thereof |
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| US5686238A (en) * | 1992-02-10 | 1997-11-11 | Baxter International Inc. | Method and device for testing blood units for viral contamination |
| CN201164594Y (en) * | 2008-03-16 | 2008-12-17 | 董美娜 | Centrifuge tube for preparing platelet-rich plasma |
| CN103505910A (en) * | 2013-10-15 | 2014-01-15 | 广东省人民医院 | Method for preparing platelet rich plasma through one-step centrifugation method |
-
2018
- 2018-06-08 CN CN201810583443.6A patent/CN108654141B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686238A (en) * | 1992-02-10 | 1997-11-11 | Baxter International Inc. | Method and device for testing blood units for viral contamination |
| CN201164594Y (en) * | 2008-03-16 | 2008-12-17 | 董美娜 | Centrifuge tube for preparing platelet-rich plasma |
| CN103505910A (en) * | 2013-10-15 | 2014-01-15 | 广东省人民医院 | Method for preparing platelet rich plasma through one-step centrifugation method |
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