CN108653512A - A kind of massage lotion and preparation method thereof for treating the various pain caused by soft tissue injury - Google Patents
A kind of massage lotion and preparation method thereof for treating the various pain caused by soft tissue injury Download PDFInfo
- Publication number
- CN108653512A CN108653512A CN201810780573.9A CN201810780573A CN108653512A CN 108653512 A CN108653512 A CN 108653512A CN 201810780573 A CN201810780573 A CN 201810780573A CN 108653512 A CN108653512 A CN 108653512A
- Authority
- CN
- China
- Prior art keywords
- soft tissue
- root
- tissue injury
- bark
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of massage lotion and preparation method thereof for treating the various pain caused by soft tissue injury, which includes following Chinese medicine material：10 15g of Chinese ephedra, 10 15g of rhizoma pinellinae praeparata, 10 15g of gypsum rubrum, 10 15g of wild aconite root, 10 15g of Chinese hydrangeavine root-bark, 10 15g of camphor, 10 15g of pyrolusite, 10 15g of semen momordicae, 10 15g of the root bark of tree peony, 10 15g of honeysuckle.Said medicine just selects that medicine is superior, prescription is rigorous, compatibility is proper, synergistic entirely, and is prepared by science, and local administration is uniform, it is easy to operate, the effect of with various pain caused by treatment acute or chronic soft tissue injury, it can quickly and effectively relieve pain, promote the reparation of soft tissue injury, and it has no toxic side effect, securely and reliably, curative effect is stablized, and cure rate is high, it is of low cost, patient's no pain.
Description
Technical field
It is the present invention relates to clinically to treat the massage lotion of disease, more particularly to a kind of to treat caused by soft tissue injury
The massage lotion and preparation method thereof of various pain.
Background technology
Soft tissue injury refer to the reasons such as various acute traumas or chronic strain and self-disease cause human body skin,
The pathologic lesion of the soft tissues such as subcutaneous fascia, muscle, tendon, ligament, capsular ligament, synovial bursae and neural blood vessel.Clinical manifestation
It is the common disease and frequently-occurring disease of the section office such as massage section, orthopaedics, department of acupuncture and moxibustion for local pain, swelling, deformity, dysfunction etc..Its
The common cause of disease has tumble injury, abrades, injures, damage etc. caused by injury gained in sports and permanent faulty posture, is mainly in person between twenty and fifty.
With the quickening pace of modern life, the incidence of the change of working method and the increase of stress, soft tissue becomes in rising
Gesture, the pain generated also drastically influence work quality and quality of life.Doctor trained in Western medicine is mainly using oral Indomethacin, Bu Luo
The anti-inflammatory analgesics class such as sweet smell, Fenbid, Voltarol drug, physiotherapy, operation etc., although can be with quickly alleviating pain, due to medicine
The reasons such as the adverse reaction of object, the easy recurrent of disorders post surgery, longer, its follow-up medical expense costliness for the treatment of cycle limit it
Extensive use in clinic.Chinese medicine mainly uses the therapies such as acupuncture, massage, the external application of Chinese medicine, although acupuncture can quickly have
Effect analgesic and prognosis bona, but pain when its acupuncture is impatient at by patient, massages and the external application of Chinese medicine all damages soft tissue
Wound has good effect, can avoid the pain in therapeutic process well.In clinic normal someone with massage in conjunction with massage medium come
It is treated, treatment improves a lot than the effect of simple massage and Traditional Chinese medicine external medicinal；Pressing for soft tissue injury is treated at present
Dairy products class of rubbing is numerous, but due to many-sided, curative effect is still not fully up to expectations, therefore seeks safer more effective treatment
Pharmaceutical formulation seems more urgent.
Invention content
In view of the deficiencies of the prior art, the object of the present invention is to provide a kind of various pain treated caused by soft tissue injury
Massage lotion and preparation method thereof, can effectively solve soft tissue injury leads to various pain problems.
To achieve the goals above, the technical scheme is that：
A kind of massage lotion for treating the various pain caused by soft tissue injury, including following Chinese medicine material：Chinese ephedra 10-15g,
Rhizoma pinellinae praeparata 10-15g, gypsum rubrum 10-15g, wild aconite root 10-15g, Chinese hydrangeavine root-bark 10-15g, camphor 10-15g, pyrolusite 10-15g,
Semen momordicae 10-15g, root bark of tree peony 10-15g, honeysuckle 10-15g.
Preferably, the massage lotion of the various pain caused by soft tissue injury, including following Chinese medicine material are treated：Chinese ephedra 10,
Rhizoma pinellinae praeparata 10g, gypsum rubrum 10g, wild aconite root 10g, Chinese hydrangeavine root-bark 10g, camphor 10g, pyrolusite 10g, semen momordicae 10g, root bark of tree peony 10g,
Honeysuckle 10g.
It is former to weigh each Chinese medicine by weight for a kind of preparation method of massage lotion that treating the various pain caused by soft tissue injury
Material, 70% ethanol solution that 6 times of raw material gross weight is added are heated to reflux 1.5h, filter, and collect filtrate；Then it is added into the dregs of a decoction
70% ethanol solution of 4 times of dregs of a decoction weight is heated to reflux 1.5h, and filtrate is collected in filtering, merges secondary filtrate, stands for 24 hours, mistake
Filter, filtrate recycling ethanol are simultaneously condensed into paste, set dry 6h in 60 DEG C of vacuum drying chambers, let cool, crush, medicinal powder is made；So
Customary adjuvant is added afterwards, massage lotion is made.
The preparation method of massage lotion：By ready stearic acid 150g, albolene 100g, single stearic acid glycerine lipoprotein 85g
It is put into oil phase heating reaction kettle, is heated to 80 DEG C of meltings, heat preservation is spare；The another Tween-80 30g, sorbic acid 2g, sweet of taking
Oil 75, pure water 500ml are heated in water phase in retort, are heated to 80 DEG C of dissolving heat preservations, water phase is slowly added in oil phase,
It is stirred while addition to emulsification and is molded, let cool to 60 DEG C, by gained emulsifiable paste and medicinal powder with weight ratio 1.2:1 ratio pours into height
In fast mulser, carry out emulsification and semi-finished product are made, eventually by the embedding of emulsifiable paste bottle placer in moulding in pipe to obtain the final product.
Raw material of the present invention use natural traditional Chinese medicine, prepare easy, at low cost, safe to use convenient, good effect, nontoxic secondary anti-
It answers, patient's no pain is easy to receive, and is the innovation treated on soft tissue injury pharmaceutical formulation.
Specific implementation mode
The specific implementation mode of the present invention is described in further detail with reference to embodiments.
Embodiment 1
A kind of massage lotion for treating the various pain caused by soft tissue injury, including following Chinese medicine material：Chinese ephedra 10, method half
Summer 10g, gypsum rubrum 10g, wild aconite root 10g, Chinese hydrangeavine root-bark 10g, camphor 10g, pyrolusite 10g, semen momordicae 10g, root bark of tree peony 10g, gold and silver
Flower 10g.
Preparation method is：Each Chinese medicine material is weighed by weight, and 70% (v/v) ethyl alcohol that 6 times of raw material gross weight is added is molten
Liquid is heated to reflux 1.5h, and filtrate is collected in filtering；Then 70% (v/v) ethanol solution that 4 times of dregs of a decoction weight is added into the dregs of a decoction adds
Heat reflux 1.5h, filtering collect filtrate, merge secondary filtrate, stand for 24 hours, filtering, filtrate recycling ethanol is simultaneously condensed into thick paste
Shape sets dry 6h in 60 DEG C of vacuum drying chambers, lets cool, crush, medicinal powder is made；By ready stearic acid 150g, albolene
100g, single stearic acid glycerine lipoprotein 85g are put into oil phase heating reaction kettle, are heated to 80 DEG C of meltings, are kept the temperature spare (oil phase)；Separately take
Tween-80 30g, sorbic acid 2g, glycerine 75, pure water 500ml are heated in water phase in retort, are heated to 80 DEG C of dissolvings
It keeps the temperature (water phase), water phase is slowly added in oil phase, stirred while being added to emulsification and be molded, let cool to 60 DEG C, by gained
Emulsifiable paste is with medicinal powder with weight ratio 1.2:1 ratio is poured into high-speed emulsifying machine, carries out emulsification and semi-finished product are made, eventually by emulsifiable paste
Bottle placer embedding is in moulding in pipe to obtain the final product.
Embodiment 2
A kind of massage lotion for treating the various pain caused by soft tissue injury, including following Chinese medicine material：Chinese ephedra 15, method half
Summer 15g, gypsum rubrum 12g, wild aconite root 15g, Chinese hydrangeavine root-bark 12g, camphor 15g, pyrolusite 15g, semen momordicae 12g, root bark of tree peony 12g, gold and silver
Flower 12g.
Preparation method is the same as embodiment 1.
Embodiment 3
A kind of massage lotion for treating the various pain caused by soft tissue injury, including following Chinese medicine material：Chinese ephedra 12, method half
Summer 12g, gypsum rubrum 15g, wild aconite root 12g, Chinese hydrangeavine root-bark 15g, camphor 12g, pyrolusite 12g, semen momordicae 15g, root bark of tree peony 15g, gold and silver
Flower 15g.
Preparation method is the same as embodiment 1.
In said medicine, wherein：
Chinese ephedra：Acrid flavour, slight bitter are warm-natured.Return lung, bladder warp.It is interior can inducing sweat and dispelling exogenous evils, freeing lung and relieving asthma, inducing diuresis for removing edema.External enwergy temperature
Degrading the channel is dissipated and is stagnated.Cure mainly chill exterior syndrome, cough and asthma real example, geomantic omen oedema.
Rhizoma pinellinae praeparata：Acrid flavour, it is warm-natured.Returns spleen, stomach, lung channel.It is eliminating dampness and eliminating phlegm, dissipating bind.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, wind
Phlegm dizziness, phlegm and headache.
Gypsum rubrum：It is acrid flavour, salty, it is cold in nature.The thoughts of returning home, stomach, kidney channel.Clearing heat-fire, relieving restlessness are quenched the thirst.For polydipsia of generating heat, throat
Swelling and pain, aphthae, toothache；Burn and scald is controlled in external application.
Wild aconite root：Acrid flavour, hardship, property heat.The thoughts of returning home, liver,kidney,spleen warp.Dispelling wind and eliminating dampness, antalgic.For wind-cold-dampness arthralgia, close
Crymodynia is saved, cold hernia is had a pain, trusted subordinate's crymodynia.
Chinese hydrangeavine root-bark：It is lightly seasoned, it is cool in nature.Converge to the spleen channel.Relaxing tendons and activating collaterals, expelling wind and activating blood flow.Cure mainly rheumatism tinea pedis, chill rheumatism, four limbs
Joint pain.
Camphor：Acrid flavour, it is warm-natured.Thoughts of returning home warp, the spleen channel.It is sensible to ward off dirty, warm in pain, dampness removing desinsection.It vomits and diarrhoea for cold-dampness, stomach
Abdomen pain；External application controls scabies, tinea, saprodontia and has a pain.
Pyrolusite：It is sweet in flavor, mild-natured.Return kidney, Liver Channel.Dissolving stasis and hemostasis, swelling and pain relieving, myogenic sore.Main traumatic injury, metal-inflicted wound
Bleeding, carbuncle swells sore, scald.
Semen momordicae：Bitter, micro-sweet, it is cool in nature；It is toxic.Return liver, spleen, stomach.Mass dissipating and swelling eliminating attacks poison and treats sore.It is swollen for sore
Poison, acute mastitis, scrofula, anal fistula, chronic eczema, the favus of the scalp.
The root bark of tree peony：Bitter, pungent, cold nature.The thoughts of returning home, liver and kidney channel.Clearing heat and cooling blood, it is promoting blood circulation and removing blood stasis.Heat enters ying blood, febrile virulent maculae,
Hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, the pain of injury caused by falling and tumbling, carbuncle sore tumefacting virus.
Honeysuckle：It is sweet in flavor, it is cold in nature.Return lung, the heart, stomach.It is clearing heat and detoxicating, fry charcoal cooling blood and hemostasis.Affection of exogenous wind-heat, warm disease hair
Heat；Toxic-heat and blood stasis；Carbuncle swells furunculosis；Larynx numbness and multi-infection disease.
In we's composition, monarch：Pyrolusite dissolving stasis and hemostasis, swelling and pain relieving, myogenic sore, honeysuckle removing toxic substances dissipate wind-heat, the two
Compatibility can solve acute swelling pain；Wild aconite root dispelling cold and removing dampness, it is pungent to alter dredging collateral, it can treat from the beginning of cold solidifying pain with pyrolusite and with the passing of time tremble with fear
The stagnant pain of dampness, three medicines are dredged through removing obstruction in channels to relieve pain in terms of cold, the wet, stasis of blood, the heat toxin four jointly.
Minister：Chinese hydrangeavine root-bark, camphor help pyrolusite promoting blood circulation to remove blood stasis to relieve pain, detumescence and promoting granulation, rhizoma pinellinae praeparata, two medicine eliminating dampness of semen momordicae
Phlegm, toxic removing dispersing swelling and dissipating binds help wild aconite root dehumidifying with mass dissipating and swelling eliminating, and gypsum rubrum clearing heat-fire helps honeysuckle clearing heat and detoxicating to subside a swelling
Analgesic.
Assistant makes：Root bark of tree peony cooling and activating blood, and clear interior heat are hot and suffocating；Chinese ephedra inducing diaphoresis dispersing wind and cold, opens and lets out space between skin and muscles, and temperature three-way meridian, dissipates
It stagnates；Body surface is not reached to remove strongly fragrant long yang-energy, all medicines is enable preferably to be absorbed into body.
Said medicine just selects that medicine is superior, prescription is rigorous, compatibility is proper, synergistic entirely, and is prepared by science, locally gives
Medicine is uniform, easy to operate, has the effect of various pain caused by treatment acute or chronic soft tissue injury, can quickly and effectively alleviate pain
Bitterly, promote the reparation of soft tissue injury, and have no toxic side effect, securely and reliably, curative effect is stablized, and cure rate is high, of low cost, patient
No pain.The party forms massage lotion by clinic application, achieves good effect, relevant information is as follows.
1, the standard of case is selected
1.1 general information
In December, -2017 in January, 2015 is with the pain caused patient of the various soft tissue injuries of massage lotion of the present invention treatment 360
Example, 253 people of male, 107 people of women, age reckling 16 years old, the maximum 60 years old, average age 38.5 years old；The course of disease most short person 3
It, most elder 15 years.Lumbar soft tissue injury 137, back soft tissue injury 64, neck soft damage 101, other
58, position.Subject is divided into treatment 1 group 90 at random with random digits table, treats 2 groups 90, treats 3 groups 90,
Control group 90.
1.2 diagnostic criteria
According to《Chinese medical disease Standardization of diagnosis and curative effect》With《New Chinese medicine clinical guidance principle》In related soft tissue injury
Diagnostic criteria.1. having apparent trauma history or chronic internal lesion caused by overexertion history, sharp ache or pain are lasting, may occur in which local swelling, limb
Body moving obstacle；2. injury tenderness is apparent, it may occur in which that the livid purple ecchymosis in part, severe patient may occur in which that subcutaneous hematoma, fluctuation sign are positive；
3. x-ray inspection excludes fracture, dislocation and osteopathy etc..
1.3 experiment case standards
1.3.1 being included in case standard
1. meeting above-mentioned diagnostic criteria；
2. age 16-60 year person.
1.3.2 Excluded cases standard
1. not meeting above-mentioned soft tissue injury diagnostic criteria person；
2. skin disease and swelling and pain person caused by infection；
3. having apparent and folder card or complication person；
4. nursing period and pregnancy women；
5. allergic constitution person, and have allergies person to drug in this massage lotion；
6. having, severe cardiac, Liver and kidney function are abnormal, and spirit, disturbance of intelligence person；
7. the state of an illness is more critical, it is difficult to which validity and safety to new drug make accurate estimator；
8. abandon receiving other therapies between treatment or observation period halfway, curative effect person can not be judged.
1.3.3 the standard that falls off and processing
It is all to treat less than 3 course for the treatment of symptoms disappearance voluntarily drug withdrawal person, not as the case that falls off.After subject falls off, grind
Study carefully personnel to contact with subject, inquiry reason, completes the evaluation item that can be done at record last time administration time.Because of mistake
Quick reaction, adverse reaction and exit experiment case, researcher should take corresponding treatment to arrange according to subject's actual conditions
It applies.Experiment case is exited because treatment is invalid, record and reservation case observation table are included into futile treatment.
2, therapeutic scheme
2.1 therapy
1,2,3 group for the treatment of selects the massage lotion of the embodiment of the present invention 1,2,3 for medium progress massage treatment respectively, and daily one
Secondary, each 10-20min, 7 days are 1 course for the treatment of, treat 3 courses for the treatment of, and control group then uses dieda wanhua oil to carry out massage treatment,
Four groups of massage treatment gimmicks, time, courses for the treatment of are all consistent, and during treatment, if there is cured person to stop treatment, non-cured person continues to control
It treats, until 3 courses for the treatment of terminate.Period deactivates other treatment and drug.
Dieda wanhua oil forms：It is wild chrysanthemum, the root of three-nerved spicebush, water banyan, paniculate swallowwort, garlic, purslane, green onion, honeysuckle-leaf, black old
Tiger, the root of Chinese clematis, common bombax bark, native asarum, flower of kudzuvine, corymb polycarpaea herb, Chinese tinospora stem, frutus cnidii, berchemia lineata, Common Achyranthes Herb, bush, rheum officinale, mountain
The root of Dahurain angelica, bicolor cross pool snake, sarcandra, hypericum japonicum, tassel flower, Radix zanthoxyli, Herba Lycopi, safflower, pipewort, native pseudo-ginseng, kapok
Flower, ghostplant wormwood herb, windproof, cacumen biotae, vomiting nut, Balsamiferou Blumea Herb, Flos Mume, eclipta, Basil, withy, cape jasmine, castor bean, three
Rib (system), polygonum flaccidum, curcuma zedoary (system), chaulmoogra (benevolence), lotus leaf, Selaginella tamariscina, fructus viticis, gleditsia sinensis, the root of Dahurain angelica, the rhizome of davallia, peach kernel, tree peony
Skin, Rhizoma Chuanxiong (system), Exocarpium Citri Grandis, green peel, dried orange peel, bletilla, the coptis, radix paeoniae rubra, cattail pollen, the achene of Siberian cocklebur, unprocessed Arisaema erubescens, shellac, white Hu
Green pepper, rhizoma cyperi (system), nutmeg, fructus amomi, Asian puccoon, Rhizoma Et Radix Notopterygii, in one's early teens, Radix Angelicae Pubescentis, rhizoma zingiberis, fructus piperis longi, beautiful sweetgum resin, borneol, peppermint oil, pine
Fuel-economizing, gaultherolin, camphorated oil, eucalyptus oil, basil oil, fennel oil, cassia oil.
2.2 parameters for observation on effect refer to table 1.
1 patient symptom standards of grading of table
2.3 criterion of therapeutical effect
Recovery from illness：The symptoms such as pain, swelling, ecchymosis, somatic feature score reduce >=90% or more, and joint motion is normal.It is effective：Pain
Bitterly, the symptoms such as swelling, ecchymosis, somatic feature score reduce >=70%,<90%, joint motion is unrestricted.Effectively：Pain, swelling, the stasis of blood
The symptoms such as spot, somatic feature score reduce >=30%,<70%, joint motion improves.In vain：The symptoms such as pain, swelling, ecchymosis, sign
Integral is reduced less than 30%, and joint motion is unchanged.
Total effective rate=(recovery from illness example+effective example+effective example)/case load × 100%
3, statistical method and result
3.1 statistical method
1. measurement data：Meet normal distribution person and carry out t inspections, comparison among groups use two independent samples t tests.Compare two-by-two
It is examined compared with using LSD.It does not meet normal distribution and then uses rank sum test.
2. enumeration data：Compare between two population rates (or composition ratio), uses χ2Inspection or exact propability, multiple samples
Compare between rate or composition ratio, using contingency table χ2It examines.
3. ranked data：Using Kruskal-Wallis H rank sum tests.
3.2 treatment results
360 patients treat 1 group of healing 39 after treatment；Effective 40；Effective 7；Invalid 4；Cure rate is
43.3%, total effective rate 95.6%；
Treat 2 groups of healings 32；Effective 47；Effective 8；Invalid 3；Cure rate is 35.6%, and total effective rate is
96.7%；
Treat 3 groups of healings 23；Effective 44；Effective 16；Invalid 7；Cure rate is 25.6%, and total effective rate is
92.2%；
Control group cures 25；Effective 49；Effective 13；Invalid 3；Cure rate is 27.8%, and total effective rate is
93.3%.
Through statistical analysis, the four groups of total effective rate indifference opposite sex (χ2=2.655；P=0.448>0.05)；
Treat 1 group and the significant difference (χ of control group cure rate2=4.752；P=0.029<0.05)；Illustrate treatment 1
Cure rate effect in group is better than control group；
2,3 groups for the treatment of and control group cure rate there was no significant difference (χ2=2.380；P=0.304>0.05)；Illustrate to treat
2,3 groups with control group the effect of it is suitable.
The above result shows that the effect for the treatment of group is good, the formula that 1 group is treated in treatment group is optimal, treats 2,3 groups
With control group therapeutic equivalence, consider that this formula composition is few, selects medicine superior, manufacture craft is relatively easy from formula composition drug.Therefore
The massage lotion of this formula composition has more preferable application prospect to the treatment of soft tissue injury, is more suitable for the popularization of clinical application.
Conclusion
From the above situation：The present invention using Local out dressing smear medication method, coordinate massage manipulation, make drug and
Local soft tissue is acted on of both massage manipulation, smears medication and quilt is transported by Sweat glands channel, cuticula and epidermis deep layer
Local soft tissue absorbs, and while outer spreading smears medication, can locally form a kind of sweat and be difficult to the relatively closed of evaporation and diffusion
State improves water content of stratum corneum, and by aquation, cuticula expansion is in porous state, is more conducive to Medicated Permeation suction
It receives, the local epidermis sweat gland of massage manipulation stimulation, cuticula and soft tissue more promote the absorption of external used medicine.Contain in the present invention
There are Chinese herbs for relieving exterior syndrome, inducing diaphoresis effect that Sweat glands channel is made to expand, cuticula transhipment and epidermis deep layer transport speed increase, while
The expansion for stimulating local vascular promotes drug to be absorbed and permeated, then the degrading the channel massaged to accelerate blood circulation,
Lively atmosphere blood, the effect for the pain that relieves the pain, factors collaboration so that soft tissue injury is local and surrounding blood vessel dilatation, blood flow add
Soon, histocyte membrane permeability increases, and local soft tissue Nutrition and Metabolism improved, and regeneration is accelerated, to generate analgesia,
The effect of anti-inflammation detumescence, the final reparation for promoting soft tissue injury, pain, swelling disappear, and functional activity is normal, disease recovery from illness.
The manufacture craft of the present invention is simple, at low cost, and drug is lacked using essence, and significant in efficacy, safe to use, local administration is uniform, makes
Easy to operate with massage lotion Combined with Massage, the few pain of patient, no toxicity, patient is willing to accept, total effective
Rate can reach 96.7%, and clinical meaning is great, is the innovation treated on soft tissue injury drug, mitigates for soft tissue injury patient
Slight illness on body and mind and psychological burden, are also made that creative contribution for human health cause.
The foregoing is merely the embodiments that the present invention is best, and for those skilled in the art, the present invention can have
Various modifications and variations.All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on, should all
It is included within protection scope of the present invention.
Claims (6)
1. a kind of massage lotion for treating the various pain caused by soft tissue injury, which is characterized in that including following Chinese medicine material：Fiber crops
Yellow 10-15g, rhizoma pinellinae praeparata 10-15g, gypsum rubrum 10-15g, wild aconite root 10-15g, Chinese hydrangeavine root-bark 10-15g, camphor 10-15g are unknown
Different 10-15g, semen momordicae 10-15g, root bark of tree peony 10-15g, honeysuckle 10-15g.
2. the massage lotion of the various pain caused by treatment soft tissue injury according to claim 1, which is characterized in that preferably
, including following Chinese medicine material：Chinese ephedra 10, rhizoma pinellinae praeparata 10g, gypsum rubrum 10g, wild aconite root 10g, Chinese hydrangeavine root-bark 10g, camphor 10g, nothing
Name different 10g, semen momordicae 10g, root bark of tree peony 10g, honeysuckle 10g.
3. the massage lotion of the various pain caused by treatment soft tissue injury according to claim 1, which is characterized in that including
Following Chinese medicine material：Chinese ephedra 15, rhizoma pinellinae praeparata 15g, gypsum rubrum 12g, wild aconite root 15g, Chinese hydrangeavine root-bark 12g, camphor 15g, pyrolusite
15g, semen momordicae 12g, root bark of tree peony 12g, honeysuckle 12g.
4. the massage lotion of the various pain caused by treatment soft tissue injury according to claim 1, which is characterized in that including
Following Chinese medicine material：Chinese ephedra 12, rhizoma pinellinae praeparata 12g, gypsum rubrum 15g, wild aconite root 12g, Chinese hydrangeavine root-bark 15g, camphor 12g, pyrolusite
12g, semen momordicae 15g, root bark of tree peony 15g, honeysuckle 15g.
5. a kind of preparation of the massage lotion of the various pain caused by treatment soft tissue injury according to any one of claims 1-4
Method, which is characterized in that weigh each Chinese medicine material by weight, 70% ethanol solution that 6 times of raw material gross weight is added is heated to reflux
Filtrate is collected in 1.5h, filtering；Then 70% ethanol solution that 4 times of dregs of a decoction weight is added into the dregs of a decoction is heated to reflux 1.5h, mistake
Filtrate is collected in filter, merges secondary filtrate, is stood for 24 hours, and filtering, filtrate recycling ethanol is simultaneously condensed into paste, and it is dry to set 60 DEG C of vacuum
Dry 6h, lets cool in dry case, crushes, and medicinal powder is made；Then customary adjuvant is added, massage lotion is made.
6. the preparation method of the massage lotion of the various pain caused by treatment soft tissue injury according to claim 5, special
Sign is, the preparation method of massage lotion：Ready stearic acid 150g, albolene 100g, single stearic acid glycerine lipoprotein 85g are put
Enter in oil phase heating reaction kettle, be heated to 80 DEG C of meltings, heat preservation is spare；Separately take Tween-80 30g, sorbic acid 2g, glycerine
75, pure water 500ml is heated in water phase in retort, is heated to 80 DEG C of dissolving heat preservations, water phase is slowly added in oil phase, is being added
It is stirred while entering to emulsification and is molded, let cool to 60 DEG C, by gained emulsifiable paste and medicinal powder with weight ratio 1.2:1 ratio pours into high speed
In mulser, carry out emulsification and semi-finished product are made, eventually by the embedding of emulsifiable paste bottle placer in moulding in pipe to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810780573.9A CN108653512B (en) | 2018-07-17 | 2018-07-17 | Massage lotion for treating various pains caused by soft tissue injury and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810780573.9A CN108653512B (en) | 2018-07-17 | 2018-07-17 | Massage lotion for treating various pains caused by soft tissue injury and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108653512A true CN108653512A (en) | 2018-10-16 |
| CN108653512B CN108653512B (en) | 2020-11-24 |
Family
ID=63789312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810780573.9A Active CN108653512B (en) | 2018-07-17 | 2018-07-17 | Massage lotion for treating various pains caused by soft tissue injury and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108653512B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166979A (en) * | 1997-02-28 | 1997-12-10 | 雷中伟 | Effective burn and scald medicine |
| CN101129640A (en) * | 2007-08-22 | 2008-02-27 | 常换领 | Medicine for reliving inflammation and pain |
| CN105688174A (en) * | 2016-03-30 | 2016-06-22 | 陈廷明 | Traditional Chinese medicine composition for alleviating pain and method for preparing plaster |
-
2018
- 2018-07-17 CN CN201810780573.9A patent/CN108653512B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166979A (en) * | 1997-02-28 | 1997-12-10 | 雷中伟 | Effective burn and scald medicine |
| CN101129640A (en) * | 2007-08-22 | 2008-02-27 | 常换领 | Medicine for reliving inflammation and pain |
| CN105688174A (en) * | 2016-03-30 | 2016-06-22 | 陈廷明 | Traditional Chinese medicine composition for alleviating pain and method for preparing plaster |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108653512B (en) | 2020-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100402066C (en) | Plaster for treating rheumatism and osteoarthrosis | |
| CN104208580B (en) | It is a kind of to treat Chinese medicine composition for the treatment of rheumatic ostealgia and preparation method thereof | |
| CN113456779A (en) | Traditional Chinese medicine medicated wine for massaging and smearing, preparation method and application thereof | |
| CN107669935A (en) | A kind of Chinese medicine antiallergy beauty mask and preparation method thereof | |
| CN107261026A (en) | A kind of medicinal liquor for preventing and treating rheumatalgia and preparation method thereof | |
| CN103705737B (en) | A kind of external-applied ointment for assistance of acupuncture therapy | |
| CN105943705A (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof | |
| CN101987135B (en) | Medicine for treating tetanus and preparation method thereof | |
| CN108653512A (en) | A kind of massage lotion and preparation method thereof for treating the various pain caused by soft tissue injury | |
| CN102949507B (en) | Traditional Chinese medicine lotion for treating lumbocrural pain and preparation method thereof | |
| CN105561270A (en) | Analgesic Chinese herbal medicine for external application and preparation method thereof | |
| CN111202835A (en) | Vinasse traditional Chinese medicine bag for treating rheumatic arthralgia, lumbar muscle strain and joint injury | |
| CN104383175A (en) | Medicine for treating chronic osteomyelitis and preparation method of medicine | |
| CN105688170A (en) | External traditional Chinese medicinal composition for treating stroke, preparation of external traditional Chinese medicinal composition and preparation method of external traditional Chinese medicinal composition | |
| CN106177785A (en) | A kind of medicine treating cervical spondylosis | |
| CN105709194A (en) | Traditional Chinese medicine composition for treating stroke and external preparation thereof and preparation method of external preparation | |
| CN104922595A (en) | Traditional Chinese medicinal preparation for herpes zoster and preparation method thereof | |
| CN113197939A (en) | Traditional Chinese medicine composition for treating rheumatic cold arthralgia | |
| CN115708848A (en) | A topical lotion for treating and preventing dermatoses | |
| CN115400200A (en) | Rheumatism treatment medicament and preparation process thereof | |
| CN104887965A (en) | Traditional Chinese medicine preparation for treating spondylo-arthritis and preparation method thereof | |
| CN113288948A (en) | Medicine for relieving external humeral epicondylitis | |
| CN104491364A (en) | Pill for treating chronic lymphocytic thyroiditis and preparation method | |
| CN117462617A (en) | A series of Chinese medicinal preparations for treating femur head necrosis | |
| CN103877557A (en) | Chinese medicament ointment for treating onychomycosis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |