CN108653168B - A kind of face cleaning gel and preparation method thereof - Google Patents

A kind of face cleaning gel and preparation method thereof Download PDF

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Publication number
CN108653168B
CN108653168B CN201810685331.1A CN201810685331A CN108653168B CN 108653168 B CN108653168 B CN 108653168B CN 201810685331 A CN201810685331 A CN 201810685331A CN 108653168 B CN108653168 B CN 108653168B
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extract
face cleaning
parts
sodium
cleaning gel
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CN108653168A (en
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何廷刚
关淑敏
艾勇
朱思阳
朱植谱
杨青文
方丽
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Hua An Tang Biotech Group Co Ltd
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Hua An Tang Biotech Group Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/596Mixtures of surface active compounds

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Abstract

The invention discloses a kind of face cleaning gels, by weight, including following component: 10-35 parts of alkanoylamino acid surfaces activating agent;10-35 parts of amphoteric surfactant;1-5 parts of nonionic surfactant.The nonionic surfactant of certain content by being added in the alkanoylamino acid surfaces activating agent of certain content and the amphoteric surfactant of certain content by the present invention, pass through the coordinated of each component, the face cleaning gel clear appearance being prepared is transparent, and there is certain viscosity, stability is good, foam exquisiteness is plentiful, with good cleaning capacity, and skin allergy and stimulation will not be caused, feel more pleasant not tight after, it is easy to use, can meet very well can effective cleaning skin while consumer pursues the quality of appearance, mild inirritative demand.And preparation process of the present invention is simple, it is easy to accomplish, it can be with scale volume production.

Description

A kind of face cleaning gel and preparation method thereof
Technical field
The present invention relates to daily cosmetics technical field, in particular to a kind of face cleaning gel and preparation method thereof.
Background technique
In daily life, due to can be accumulated on the skins such as the pollutants such as dust in air, cosmetics residual various greases, Dirt, if cleaned not in time, remaining grease, dirt are easy blocking pore, the skin problem such as cause blackhead, pore coarse. Face cleaning plays an important role to skin care as the first step of skin basic nursing, the excess oil on thorough cleaning skin surface and Dirt facilitates the absorption of subsequent skin care item.
In recent years, consumer constantly promotes the attention rate of face cleaning product mildness.Strong cleaning force, fizzy soap Fundamental mode face cleaning product, since degreasing power is strong, skin water shortage is tight after cleaning, is easy to damage skin.But for other kinds of For face cleaning product, the usual appearance of face cleaning gel on the market is in semi-permeable zone of opacity frosted shape, and viscosity is excessively high, is in jelly Shape will affect use feeling and foam again, be unable to satisfy consumer for appearance quality pursue while can effective cleaning skin, Mild inirritative demand.
Summary of the invention
In view of above-mentioned deficiencies of the prior art, primary and foremost purpose of the present invention is to provide that a kind of appearance is clear, foaming abundancy is fine and smooth, Mild non-stimulated and good with certain viscosity, stability face cleaning gel.
An other purpose of the invention is to provide the preparation method of above-mentioned face cleaning gel.
Face cleaning gel of the present invention, by weight, including following component:
10-35 parts of alkanoylamino acid surfaces activating agent;
10-35 parts of amphoteric surfactant;
1-5 parts of nonionic surfactant.
Preferably, the face cleaning gel, by weight, including following component:
15-30 parts of alkanoylamino acid surfaces activating agent;
15-30 parts of amphoteric surfactant;
2-4 parts of nonionic surfactant.
Wherein, the mass concentration of the alkanoylamino acid surfaces activating agent is 25%-35%, is selected from alkanoyl glycine The mixing of one or both of salt, Alkanoyl sarcosinates.
Preferably, the alkanoyl glycinate in cocoyl Sodium Glycinate or cocoyl glycine potassium one Kind or two kinds of mixing;The Alkanoyl sarcosinates in cocoyl Sodium Glycinate or cocoyl glycine potassium one Kind or two kinds of mixing;Preferably, the alkanoyl sodium sarcosinate is selected from sodium N-lauroyl sarcosinate, myristoy sarcosine One or more of sodium, palmitoyl sarcosine sodium, Sodium Coco acylsarcosinate, lauroyl sarcosine potassium.
Wherein, the mass concentration of the amphoteric surfactant is 20-50%, is selected from Cocoamidopropyl betaine, cocounut oil It is amide ethyl glycine betaine, lauroylamidopropyl betaine, palmitamide propyl betaine, myristamide propyl betaine, hard Rouge amido propyl betaine, palmitoleoyl both sexes guanidine-acetic acid sodium, myristoyl both sexes guanidine-acetic acid sodium, stearoyl both sexes guanidine-acetic acid One of sodium, sodium cocoamphoacetate, Sodium Lauroamphoacetate, lauroyl both sexes base diethyl acid disodium are several Kind.
Wherein, the nonionic surfactant is selected from PEG-120 methyl dioleate, PEG-120 methyl Portugal Sugared trioleate, three isostearate of PEG-120 methyl, coconut oleoyl amine methyl MEA, palmitoleic acid amide MEA, the moon One or more of osmanthus amide MEA, acetamide MEA, coconut oleoyl amine DEA, lauramide DEA;Preferably PEG-120 One or two kinds of mixing of methyl dioleate, coconut oleoyl amine methyl MEA.
Face cleaning gel of the present invention further includes by weight 1-5 parts of moisturizer, 0.01-0.5 parts of skin conditions Agent, 0.01-0.1 parts of chelating agents and 50-80 parts of water.
Wherein, moisturizer is selected from one or more of glycerol, propylene glycol, butanediol, pentanediol, isoprene.
Wherein, the skin conditioning agent is selected from dipotassium glycyrrhizinate, hyaluronic acid, thermal water, hydrolysis conchiolin, Ou Xia To careless (MARRUBIUM VULGARE) extract, citrus (CITRUS RETICULATA) pericarp extract, Thymus serpyllum (THYMUS SERPILLUM) extract, purslane (PORTULACA OLERACEA) extract, ginkgo (GINKGO BILOBA) Leaf extract, tea (CAMELLIA SINENSIS) leaf extract, dog rose (ROSA CANINA) berry extract, North America gold thread Plum (HAMAMELIS VIRGINIANA) extract, centella (CENTELLA ASIATICA) extract, glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract, Cnidium officinale Makino (CNIDIUM OFFICINALE) root extract, Japanese elm (ULMUS DAVIDIANA) root extract, white willow (SALIX ALBA) bark extract, cork tree (PHELLODENDRON AMURENSE) tree Bark extract, aloe barbadensis Miller (ALOE BARBADENSIS) leaf extract, fragrant citrus (CITRUS JUNOS) berry extract, Mo Jiao Algae (FUCUS VESICULOSUS) extract, lichee (LITCHI CHINENSIS) pericarp extract, rice (ORYZA SATIVA) Germ extracts, Mi Luomu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extraction, hydrolysis monkey-bread tree (ADANSONIA DIGITATA) extract, Wild soybean (GLYCINE SOJA) seed extract, Tokyo oriental cherry (PRUNUS YEDOENSIS) leaf extract, purple perilla (PERILLA OCYMOIDES) leaf extract, grape (VITIS VINIFERA) seed extract Object, edelweiss (LEONTOPODIUM ALPINUM) extract, wing seed Moringa (MORINGA PTERYGOSPERMA) seed mention Take one or more of object.
In addition, the pH value of face cleaning gel of the present invention is 7.5-8.5.
The invention also discloses the preparation methods of above-mentioned face cleaning gel, include the following steps:
(1) water, alkanoylamino acid surfaces activating agent, amphoteric surfactant, moisturizer are weighed according to the proportion, and mixing is stirred It mixes and is heated to 70-75 DEG C, nonionic surfactant is added in stirring, and stirring heat preservation 5-10 minutes transparent to being uniformly dissolved;
(2) stirring is cooled to 40-45 DEG C, and weighed skin conditioning agent, chelating agent according to the proportion is added, and stirs 5-10 minutes To homogeneous transparent, discharge filling to get face cleaning gel.
Compared with prior art, the present invention has following excellent effect:
1) present invention is sour by the alkanoylamino that the nonionic surfactant of certain content is added to certain content In surfactant and the amphoteric surfactant of certain content, by the coordinated of each component, the face cleaning that is prepared Gel clear appearance is transparent and has certain viscosity, stability good, and foam exquisiteness is plentiful, has good cleaning capacity, and not It can cause skin allergy and stimulation, feel more pleasant not tight after, it is easy to use, consumer can be met very well for appearance Quality while pursue can effective cleaning skin, mild inirritative demand.
2) preparation process of the present invention is simple, it is easy to accomplish, it can be with scale volume production.
Specific embodiment
Further illustrate that the present invention, following embodiment are the preferable embodiment party of the present invention below by specific embodiment Formula, but embodiments of the present invention are not limited by following embodiments.
The raw material that the embodiment of the present invention and comparative example use is as follows, but is not limited only to these raw materials:
Alkanoylamino acid surfaces activating agent:
Cocoyl Sodium Glycinate: mass concentration 30%, it is commercially available;
Cocoyl glycine potassium: mass concentration 30%, it is commercially available;
Sodium N-lauroyl sarcosinate: mass concentration 30%, it is commercially available;
Amphoteric surfactant:
Lauroylamidopropyl betaine: mass concentration 38%, it is commercially available;
Sodium Lauroamphoacetate: mass concentration 26%, it is commercially available;
Lauroyl both sexes base diethyl acid disodium: mass concentration 32%, it is commercially available;
Other raw materials also it is commercially available to obtain the final product.
The appearance transparence stability test method of face cleaning gel: to the face cleaning gel of embodiment 1-6 and comparative example 1-6, It is placed in 40 DEG C and stores to store within 1 month, 25 DEG C of room temperature 1 month, 4 DEG C of low temperature and store 1 month, restore to observing appearance transparent after room temperature Degree, test result are as shown in table 1.
The viscosity determining procedure of face cleaning gel: by the face cleaning gel of embodiment 1-6 and comparative example 1-6,25 DEG C of room temperature are placed in 24 hours, viscosity test is carried out, uses instrument: NDJ-1 type viscosimeter;Test condition: using No. 3 rotors, in turning for 50rpm Speed reads stable viscosity data after starting 1 minute using regulation by viscosimeter, and test result is as shown in table 1.
Embodiment 1-6 and comparative example 1-6: the preparation of face cleaning gel
Water, alkanoylamino acid surfaces activating agent, amphoteric surfactant, moisturizer are weighed according to the proportion of table 1, is mixed It is heated with stirring to 70-75 DEG C, nonionic surfactant is added in stirring, and stirring heat preservation 5-10 minutes transparent to being uniformly dissolved;It stirs It mixes and is cooled to 40-45 DEG C, be added according to the weighed skin conditioning agent of table 1, chelating agent, stirring 5-10 minutes to homogeneous transparent, out Expect filling to get face cleaning gel;Appearance transparence stability, the test result of viscosity of face cleaning gel are as shown in table 1.
The each group distribution ratio (parts by weight) of table 1 embodiment 1-6 and comparative example 1-6 and the test result of each performance indicator
Continued 1
Note: the "/" that comparative example 5 and comparative example 6 occur indicates that viscosity is too low, can not measure.
In addition, the face cleaning gel to embodiment 1-6 and comparative example 1-6 carries out skin sense evaluation:
1) test method: subject uses the face cleaning gel of embodiment 1-6 and comparative example 1-6 according to application method respectively, Foaming abundancy degree, cleaning capacity, the comfort level after and general impression when to its appearance preference degree, use are made and being commented Valence, according to 1-5 points of evaluations and assembly average.
2) subject population's number: healthy women subject of 30 ages at 18-35 years old.
3) test assessment result is as shown in table 2:
The skin sense evaluation test result of table 2 embodiment 1-6 and comparative example 1-6
In addition, doing preservation challenge test to the face cleaning gel of embodiment 1-6 and comparative example 1-6: it is all satisfied the requirement of USP 32, Product has good anti-corrosion effect.
It is tested finally, doing sensitive skin to the face cleaning gel of embodiment 1-6 and comparative example 1-6:
1) test method and number: cutaneous safety assessment is carried out using the test method of normal individual trial, tests number 40 People.Its septum reset sensitivity skin quality people is more than 30 people.
2) subject selects: healthy women subject of the age at 18-35 years old;
3) it product application method and pot life: according to product operation instruction, takes appropriate product in the centre of the palm, water is added gently to rub out After foam, it is applied to the face of wetting and is massaged, then rinsed well with clear water.
4) observing time:
It observes 4 weeks altogether.Subject is before being included in research the 7th day after (the 0th day), clinical use, the 14th day after clinical use With the 28th day after clinical use, altogether carry out 4 follow-ups.
5) sensitive skin selection criteria
Subjective assessment: head examines day doctor to subject's recipient site to weather (cold and dry), skin care product, cleaning The sensibility of agent, textile and abrasive articles scores respectively:
0 point is insensitive;1 point is sometimes sensitive;2 points are sensitivity;
5 item ratings are added, it is sensitive that total score, which is greater than 4 points of persons,.
Such as: patient A readme (0 point) insensitive to weather, to skin care product sometimes sensitive (1 point), quick to detergent Feel (2 points), to textile sometimes sensitive (1 point), to abrasive articles sometimes sensitive (1 point);Five Xiang Xiangjia: 0+1+2+1+1=5 points, Therefore, it is determined that being sensitive.
Lactic acid irritant test:
Selection semar technique is tested, and 10% lactic acid is applied to nasolabial groove and any one side face cheek at room temperature, is existed respectively 2.5 and 5 minutes sensitivity responses to subject carry out 4 grades of evaluations, and then will score addition twice, and score value is greater than 3 for sensitivity Property skin.
0 point is no shouting pain;1 point is slight shouting pain;2 points are moderate shouting pain;3 points are severe shouting pain
Subjective assessment is greater than 4 points or lactic acid irritant test is positive, all can determine that as sensitive.
6) safety evaluation:
Test products are observed by normal individual trial test to human skin safety, it is especially sensitive to face skin Person.When subject pays a return visit, any bad thing that subject is occurred during using trial target is carefully inquired, checked and record Part, performance, time of origin, treatment measures including adverse events and lapses to, and to the relationship of adverse events and used product It judges.
Adverse events severity is judged by following grade III Standard:
Slightly-subject can endure, and be not required to especially handle, do not influence the normal life of subject;
Moderate-subject is difficult to endure, and needs to deactivate product or does specially treated, influences the normal life of subject;
Severe-obstruction normal life need to deactivate immediately product or do emergent management.
Skin adverse reaction is classified specified in the versions in 2015 " cosmetics safety technical specification " issued according to the Ministry of Public Health Normal individual trial tests skin adverse reaction grading standard to judge:
0 grade (dermoanergy);
1 grade (faint erythema occurs in skin);
2 grades (erythema, infiltration and papule occurs in skin);
3 grades (erythema, oedema, papule and blister occurs in skin);
4 grades (erythema, oedema and bleb occurs in skin)
The interpretation standard of adverse events and test products relationship:
A uses test products and reaction generation event sequence reasonable certainly, stops using test products reaction stopping or fast Speed mitigates or improves, and reuses test products reaction and reproduces, while documents and materials are proved, and have removed other Confounding Factor shadows It rings;
B is reasonable most likely with test products and reacting generating time sequence, and test products reaction is stopped using to stop, or Mitigate rapidly or improve, other factors influence can be excluded substantially;
C may use test products and reacting generating time in close relations, but cause the product more than one of adverse reaction, Or there are other factors can not be excluded;
D unrelated may be occurred using test products and adverse reaction, the time it is far, reaction performance with it is known The adverse reaction of cosmetics is misfitted;
E data to be evaluated is not complete, revalues after waiting updates or causality is difficult to come to a conclusion, and lacks documents and materials Evidence;
F can not evaluate that lacuna is too many, and causality is difficult to come to a conclusion, and data can not supplement.
7) test result:
Subject's ordinary circumstance: the age of selected subject between 22 years old to 33 years old, is selected in 40 subjects altogether, wherein 40 people of women, 0 people of male, average age 25.83 years old, complete cost study.In selected subject, having 30 people is sensibility flesh Skin, wherein 3 person of dividing of lactic acid irritant test score value > is 30 people, and 8 people someone have using cosmetic allergic contact dermatitis history, and 10 people are to daily washing Product is sensitive, and 7 people are sensitive to climate change or solarization, and 5 people are to wool is contained, and cotton, the clothings such as terylene are sensitive, and 3 people are to abrasive articles Sensitivity, 0 people are sensitive to metal objects.
Safety evaluation: 40 subjects (wherein sensitive 30 people of skin person) normal individual trial experimental study in 4 weeks, without it is any not Good reaction has preferable safety, even if also showing that preferable safety to the people of sensitive skin, is suitable for sensitive flesh Skin.

Claims (8)

1. a kind of face cleaning gel, which is characterized in that based on 100 parts of parts by weight, including following component:
16.5-30 parts of alkanoylamino acid surfaces activating agent;
15-30 parts of amphoteric surfactant;
2-4 parts of nonionic surfactant;
The mass concentration of the alkanoylamino acid surfaces activating agent is 25%-35%;
The mass concentration of the amphoteric surfactant is 20-50%;
The alkanoylamino acid surfaces activating agent is selected from one or both of alkanoyl glycinate, Alkanoyl sarcosinates Mixing;
The amphoteric surfactant is selected from Cocoamidopropyl betaine, cocoamidoethyl betaine, dodecanamide propyl Glycine betaine, palmitamide propyl betaine, myristamide propyl betaine, stearamide propyl glycine betaine, palmitoleoyl two Property guanidine-acetic acid sodium, myristoyl both sexes guanidine-acetic acid sodium, stearoyl both sexes guanidine-acetic acid sodium, sodium cocoamphoacetate, lauroyl One or more of both sexes guanidine-acetic acid sodium, lauroyl both sexes base diethyl acid disodium;
The nonionic surfactant is selected from PEG-120 methyl dioleate, three oleic acid of PEG-120 methyl Ester, three isostearate of PEG-120 methyl, coconut oleoyl amine methyl MEA, palmitoleic acid amide MEA, lauramide One or more of MEA, acetamide MEA, coconut oleoyl amine DEA, lauramide DEA.
2. face cleaning gel according to claim 1, which is characterized in that it is sweet that the alkanoyl glycinate is selected from cocoyl The mixing of one or both of propylhomoserin sodium or cocoyl glycine potassium;The Alkanoyl sarcosinates are selected from cocoyl flesh The mixing of one or both of propylhomoserin sodium or cocoyl sarcosine potassium.
3. face cleaning gel according to claim 1, which is characterized in that the Alkanoyl sarcosinates are selected from lauroyl flesh Propylhomoserin sodium, myristoy sarcosine sodium, palmitoyl sarcosine sodium, Sodium Coco acylsarcosinate, lauroyl sarcosine potassium One or more of.
4. face cleaning gel according to claim 1, which is characterized in that the nonionic surfactant is selected as PEG-120 One or two kinds of mixing of methyl dioleate, coconut oleoyl amine methyl MEA.
5. face cleaning gel according to claim 1, which is characterized in that by weight, further include 1-5 parts of moisturizer, 0.01-0.5 parts of skin conditioning agents, 0.01-0.1 parts of chelating agents and 50-80 parts of water.
6. face cleaning gel according to claim 5, which is characterized in that the moisturizer is selected from glycerol, propylene glycol, fourth two One or more of alcohol, pentanediol, isoprene;The skin conditioning agent is selected from dipotassium glycyrrhizinate, hyaluronic acid, hot spring Water, hydrolysis conchiolin, marrubium (MARRUBIUM VULGARE) extract, citrus (CITRUS RETICULATA) fruit Bark extract, Thymus serpyllum (THYMUS SERPILLUM) extract, purslane (PORTULACA OLERACEA) extract, silver Apricot (GINKGO BILOBA) leaf extract, tea (CAMELLIA SINENSIS) leaf extract, dog rose (ROSA CANINA) Berry extract, hamamelis (HAMAMELIS VIRGINIANA) extract, centella (CENTELLA ASIATICA) are extracted Object, glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extract, Cnidium officinale Makino (CNIDIUM OFFICINALE) root extract, Japanese elm (ULMUS DAVIDIANA) root extract, white willow (SALIX ALBA) bark extract, cork tree (PHELLODENDRON AMURENSE) bark extract, aloe barbadensis Miller (ALOE BARBADENSIS) leaf extract, fragrant citrus (CITRUS JUNOS) fruit Extract, bladder-wrack (FUCUS VESICULOSUS) extract, lichee (LITCHI CHINENSIS) pericarp extract, rice (ORYZA SATIVA) germ extracts, Mi Luomu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extraction, hydrolysis monkey Breadfruit (ADANSONIA DIGITATA) extract, Wild soybean (GLYCINE SOJA) seed extract, Tokyo oriental cherry (PRUNUS YEDOENSIS) leaf extract, purple perilla (PERILLA OCYMOIDES) leaf extract, grape (VITIS VINIFERA) seed extract Object, edelweiss (LEONTOPODIUM ALPINUM) extract, wing seed Moringa (MORINGA PTERYGOSPERMA) seed mention Take one or more of object.
7. face cleaning gel according to claim 1, which is characterized in that the pH value of the face cleaning gel is 7.5-8.5.
8. a kind of preparation method of such as described in any item face cleaning gels of claim 1-7, which is characterized in that including walking as follows It is rapid:
(1) water, alkanoylamino acid surfaces activating agent, amphoteric surfactant, moisturizer are weighed according to the proportion, are mixed and are added For heat to 70-75 DEG C, nonionic surfactant is added in stirring, and stirring heat preservation 5-10 minutes transparent to being uniformly dissolved;
(2) stirring is cooled to 40-45 DEG C, is added weighed skin conditioning agent, chelating agent according to the proportion, and stirring 5-10 minutes is to equal It is even transparent, it discharges filling to get face cleaning gel.
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CN111671700A (en) * 2020-05-15 2020-09-18 广州市科能化妆品科研有限公司 Anti-allergy-dry composition and preparation method thereof
CN112315850B (en) * 2020-10-13 2023-02-24 广州妮趣化妆品有限公司 Self-heating gel mask cream and preparation method thereof
CN114392204A (en) * 2021-12-24 2022-04-26 广州那比昂生物科技有限公司 Skin cleaning composition and preparation method and application thereof
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KR101351869B1 (en) * 2005-05-20 2014-01-15 로디아 인코포레이티드 Structured surfactant compositions
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