CN114392204A - Skin cleaning composition and preparation method and application thereof - Google Patents

Skin cleaning composition and preparation method and application thereof Download PDF

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CN114392204A
CN114392204A CN202111598941.6A CN202111598941A CN114392204A CN 114392204 A CN114392204 A CN 114392204A CN 202111598941 A CN202111598941 A CN 202111598941A CN 114392204 A CN114392204 A CN 114392204A
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phase
cleansing
skin
weight
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刘海平
夏洁
蒙宇
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Guangzhou Nabion Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/732Starch; Amylose; Amylopectin; Derivatives thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

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Abstract

The invention belongs to the technical field of cosmetics, and discloses a skin cleaning composition, and a preparation method and application thereof. The skin cleansing composition has moderate cleansing power, abundant foam, easy rinsing, low irritation, and little damage to skin barrier. By adding the excipient into the skin cleaning composition, the excipient is approximately spherical particles after being dispersed and swelled in water, the texture is soft, and the particles are uniform; when the usage amount of the amino acid system is larger, the stability can be assisted and liquid gel can be formed; so as to achieve the purposes of shaping, stabilizing, softening the paste, quickly spreading and the like, form ice slush or ice crystal gel similar to appearance gel, effectively assist cleaning, and improve hand feeling and foam.

Description

Skin cleaning composition and preparation method and application thereof
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a skin cleaning composition as well as a preparation method and application thereof.
Background
According to the definition of "cosmetic supervision and management regulation" applied from 1/2021, cosmetics refer to daily chemical industry products applied to the surface of human body such as skin, hair, nails, lips, etc. by smearing, spraying or other similar methods for the purpose of cleaning, protecting, beautifying and decorating. The classification principle of cosmetics in China is mainly classified according to the functions and the use parts of the products. The products are classified according to their functions into cleaning cosmetics, nursing cosmetics, beautifying cosmetics and decorative cosmetics. They are classified into skin cosmetics, hair cosmetics, nail cosmetics, and lip cosmetics according to the site of use. Among them, the cleansing cosmetic is intended to remove dirt on the skin, to keep the skin fresh, and to contribute to the maintenance of the normal physiological state of the skin. The face cleaning product belongs to a major class of cosmetics and accounts for more than 10% of the cosmetic market. At present, the types of face cleaning products in domestic markets are various, the face cleaning products are increasingly paid attention by consumers and manufacturers, the requirements of people on the face cleaning products are higher and higher, and the development of the formula of the face cleaning products is more and more important.
Currently common facial cleansing products are facial cleansing cream, facial cleansing milk, facial cleansing gel (facial cleansing gel), facial cleansing bubbles (facial cleansing mousse), and the like. The cleansing cream has thicker texture, abundant foam and stronger cleaning power, has the function of makeup removal, can effectively remove isolation and sunscreen products and the like, and is suitable for the skin which is not sensitive to oiliness and mixing; the face cleanser has abundant foam, more water and milder and moist property, and generally does not stimulate the skin; the face-cleaning gel (face-cleaning gel) is more fresh and mild than face-cleaning cream and face-cleaning milk, and is suitable for sensitive and dry skin; the cleansing foam (cleansing mousse) allows abundant foam to be directly extruded from a pump port due to the progress of packaging design, has simple formula, no thickening, low surface active concentration, mildness, refreshing property and no residue, and is suitable for various skin types and seasons. With the increasingly stringent requirements of consumers on the appearance of the face cleansing product, the market demand for diversified formulations of the face cleansing product is also increasing.
The formula of the face cleaning product mainly comprises water, a surfactant, a thickening agent, a humectant, a preservative, essence and the like. Currently available facial cleansing products are roughly classified into soap-based type and amino acid type ones according to the difference in main activity. The soap-based cleansing facial mask is usually rich in foam, easy to wash, fresh and cool in skin feel and strong in cleansing force; the disadvantages are that the soap base is slightly alkaline, the degreasing force is too strong, the skin is easy to be dry and astringent after washing, the skin irritation is larger, the requirements on saponification technology such as stirring speed and temperature in the production process are higher, and the batch stability is difficult to ensure. The amino acid type cleansing is safe and mild, the cleansing power is moderate, and the skin feel is smooth; the disadvantages are that the foam is not rich enough, the consumer feels no clean after washing with false slip, the thickening is difficult, the water is easy to dissolve, and the viscosity of the material body is obviously reduced in the using process. How to match the formula of the face cleaning product ensures that the viscosity of the product is stable in the life cycle while considering rich foam, moderate cleaning power, easy washing and low irritation, and is another problem to be solved by the face cleaning product.
Disclosure of Invention
It is an object of the first aspect of the present invention to provide a skin cleansing composition.
It is an object of a second aspect of the present invention to provide the use of a skin cleansing composition of the first aspect in the preparation of a cosmetic product.
The third aspect of the invention aims to provide a face-cleaning gel.
The fourth aspect of the present invention is to provide the method for preparing the facial gel of the third aspect.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
in a first aspect of the invention, a skin cleansing composition is provided, comprising the following components in parts by weight: 10-45 parts of amino acid surfactant, 3-12 parts of auxiliary surfactant, 1-5 parts of thickening suspending agent, 4-6 parts of humectant and 0-9 parts of excipient.
Preferably, the excipient is other than 0 parts by weight.
Preferably, the skin cleansing composition comprises the following components in parts by weight: 15-40 parts of amino acid surfactant, 5-10 parts of auxiliary surfactant, 2-4 parts of thickening suspending agent, 4-5 parts of humectant and 6-7.5 parts of excipient.
Further preferably, the skin cleansing composition comprises the following components in parts by weight: 20-40 parts of amino acid surfactant, 5-10 parts of auxiliary surfactant, 3-4 parts of thickening suspending agent, 4-5 parts of humectant and 7-7.5 parts of excipient.
Preferably, the amino acid surfactant is at least one of potassium cocoyl glycinate, sodium lauroyl sarcosinate, disodium cocoyl glutamate and sodium cocoyl glycinate; further at least one of potassium cocoyl glycinate and sodium lauroyl sarcosinate.
Preferably, the sodium lauroyl sarcosinate is a sodium lauroyl sarcosinate solution; further, the lauroyl sarcosine sodium solution contains 20 to 40 wt% of sodium lauroyl sarcosine.
Preferably, the co-surfactant is at least one of sodium cocoyl methyl taurate, decyl glucoside, cocamidopropyl betaine, sodium lauroamphoacetate and sodium cocoyl isethionate; further comprises at least one of sodium cocoyl methyl taurate, decyl glucoside and cocamidopropyl betaine.
Preferably, the sodium cocoyl methyl taurate is sodium cocoyl methyl taurate solution; further a sodium cocoyl methyl taurate solution with the content of 20-40 wt% of sodium cocoyl methyl taurate.
Preferably, the cocamidopropyl betaine is cocamidopropyl betaine solution; further, the cocoamidopropyl betaine solution contains 20-40 wt% of cocoamidopropyl betaine.
Preferably, the thickening suspending agent is at least one of hydroxypropyl starch phosphate, acrylic acid (ester) copolymer and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer; further at least one of hydroxypropyl starch phosphate and acrylic acid (ester) copolymer.
Preferably, the acrylic copolymer is an acrylic copolymer solution; further, the acrylic copolymer solution contains 20-40 wt% of acrylic copolymer.
Preferably, the humectant is at least one of glycerin, sorbitol, propylene glycol, dipropylene glycol, and butylene glycol; further at least one of glycerin, propylene glycol and butylene glycol.
Preferably, the excipient is at least one of acrylic acid (ester) cross-linked polymer and sodium polyacrylate; further acrylic crosslinked polymer; the excipient is approximately spherical particles after being dispersed and swelled in water, the texture is soft, and the particles are uniform; when the usage amount of the amino acid system is larger, the stability can be assisted and liquid gel can be formed; so as to achieve the purposes of shaping, stabilizing, softening the paste, quickly spreading and the like, form ice slush or ice crystal gel similar to appearance gel, effectively assist cleaning, and improve hand feeling and foam.
In a second aspect of the invention, there is provided the use of a skin cleansing composition according to the first aspect of the invention in the preparation of a cosmetic product.
Preferably, the cosmetic is any one of a cleansing gel, a bath gel and a exfoliating gel.
In a third aspect of the invention, the facial cleansing gel comprises the following components in parts by weight: 18 to 77 parts of the skin cleansing composition of the first aspect.
Preferably, the cleansing gel comprises the following components in parts by weight: 32 to 66.5 parts of the skin cleansing composition of the first aspect.
Further preferably, the facial cleansing gel comprises the following components in parts by weight: 39-66.5 parts of the skin cleansing composition of the first aspect.
Preferably, the cleansing gel further comprises the following components in parts by weight: 0.3-0.8 part of skin conditioner.
Further preferably, the facial cleansing gel further comprises the following components in parts by weight: 0.4-0.7 parts of a skin conditioner.
Still more preferably, the cleansing gel further comprises the following components in parts by weight: 0.5-0.6 part of skin conditioner.
Preferably, the skin conditioner is at least one of a purslane extract, a wild chrysanthemum extract, a scutellaria root extract and a honeysuckle flower extract; further comprises herba Portulacae extract.
Preferably, the cleansing gel further comprises the following components in parts by weight: 0.01-0.05 part of chelating agent.
Further preferably, the facial cleansing gel further comprises the following components in parts by weight: 0.01-0.03 parts of chelating agent.
Still more preferably, the cleansing gel further comprises the following components in parts by weight: 0.01-0.02 parts of chelating agent.
Preferably, the chelating agent is at least one of disodium EDTA and tetrasodium EDTA; further disodium EDTA.
Preferably, the cleansing gel further comprises the following components in parts by weight: 0.01-0.1 part of colorant.
Further preferably, the facial cleansing gel further comprises the following components in parts by weight: 0.01-0.08 part of colorant.
Still more preferably, the cleansing gel further comprises the following components in parts by weight: 0.01-0.06 parts of a coloring agent.
Preferably, the colorant is at least one of CI 42090 and CI 19140.
Preferably, the CI 42090 is a CI 42090 solution; further, the solution is CI 42090 solution with the CI 42090 content of 0.05-0.2 wt%.
Preferably, the CI 19140 is CI 19140 solution; further, the solution of CI 19140 is 0.05-0.2 wt% of CI 19140.
Preferably, the cleansing gel further comprises the following components in parts by weight: 0.1 to 0.6 parts of aromatic.
Further preferably, the facial cleansing gel further comprises the following components in parts by weight: 0.1 to 0.5 parts of aromatic.
Still more preferably, the cleansing gel further comprises the following components in parts by weight: 0.1 to 0.3 part of aromatic.
Preferably, the fragrance is a perfume.
Preferably, the cleansing gel further comprises the following components in parts by weight: 0.5-1.5 parts of preservative.
Further preferably, the facial cleansing gel further comprises the following components in parts by weight: 0.8-1.2 parts of preservative.
Still more preferably, the cleansing gel further comprises the following components in parts by weight: 0.8-1.0 part of preservative.
Preferably, the preservative is at least one of p-hydroxyacetophenone, glyceryl caprylate, caprylhydroxamic acid and phenoxyethanol; further at least one of caprylyl hydroximic acid and phenoxyethanol.
Preferably, the cleansing gel further comprises the following components in parts by weight: 0-1.0 parts of pH regulator.
Further preferably, the facial cleansing gel further comprises the following components in parts by weight: 0-0.8 part of pH regulator.
Still more preferably, the cleansing gel further comprises the following components in parts by weight: 0-0.4 part of pH regulator.
Preferably, the pH adjuster is at least one of aminomethyl propanol, arginine, sodium hydroxide, potassium hydroxide, and triethanolamine; further triethanolamine.
Preferably, the cleansing gel further comprises the following components in parts by weight: 45-65 parts of water.
Further preferably, the facial cleansing gel further comprises the following components in parts by weight: 46.22 to 63.72 parts of water.
Still more preferably, the cleansing gel further comprises the following components in parts by weight: 46.22 to 51.22 parts of water.
In a fourth aspect of the present invention, there is provided a process for preparing a cleansing gel of the third aspect of the present invention, comprising the steps of:
mixing humectant with excipient to obtain phase A;
mixing an amino acid surfactant, an auxiliary surfactant, a thickening suspending agent and water to obtain a phase B;
mixing skin conditioner, chelating agent, pH regulator, colorant, and antiseptic to obtain phase C;
mixing the phase C with the phase B to obtain a phase D; preferably, adding the phase C into the phase B under the stirring condition to obtain a phase D;
mixing the phase D with the phase A to obtain face cleaning gel; preferably, the phase A is added into the phase D under the stirring condition, and the mixture is stirred until the paste is uniform, so that the cleansing gel is obtained.
The invention has the beneficial effects that:
the invention provides a skin cleansing composition which has moderate cleansing power, abundant lather, easy rinsing, low irritation (mildness, low dry and harsh feel) and little damage to the skin barrier.
Furthermore, by adding an excipient into the skin cleaning composition, the excipient is dispersed and swelled in water to form approximately spherical particles, the texture is soft, and the particles are uniform; when the usage amount of the amino acid system is larger, the stability can be assisted and liquid gel can be formed; so as to achieve the purposes of shaping, stabilizing, softening the paste, quickly spreading and the like, form ice slush or ice crystal gel similar to appearance gel, effectively assist cleaning, and improve hand feeling and foam.
The invention provides a face cleaning gel which has moderate cleaning power, abundant foam, easy washing, low irritation (mild and low dry and astringent feeling) and small damage to skin barriers.
Furthermore, the face-cleaning gel has the ice sand appearance and the unique crystal ice sand appearance by adding the excipient into the face-cleaning gel, and when the face-cleaning gel is used, the fine ice sand particles have soft and comfortable frosting feeling during rubbing, so that a pleasant and unusual face-cleaning experience is brought to consumers; the face-cleaning gel formula system adopts a mild amino acid surfactant as a main surfactant, and matches a nonionic glycoside or amphoteric surfactant and the like as auxiliary surfactants, so that the face-cleaning gel is mild, free of stimulation, rich in foam, moderate in cleaning force, free of dryness after washing and good in use feeling; the face-cleaning gel does not need saponification or high-speed homogeneous emulsification, has low energy consumption, simple and convenient production process, sanitary and safety indexes meeting national relevant regulations, and has stable product and wide application value.
Drawings
FIG. 1 is an appearance diagram of cleansing gels prepared in examples 1 to 6.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
The starting materials used in the examples were prepared by conventional means or purchased from commercial sources, except as otherwise specified.
In this embodiment: glycerol was purchased from high-tech limited, de source (china); propylene glycol was purchased from SK picglobal co, ltd.; butanediol is available from OQ Chemicals Corporation; the acrylic acid (ester) cross-linked polymer is purchased from Sochang bioscience, Guangzhou, and has the product model of SC-21A; potassium cocoyl glycinate was purchased from Ajinomoto co, inc; sodium lauroyl sarcosinate was purchased from guangzhou, granted high-new materials, inc; decyl glucoside was purchased from basf (china) ltd; cocamidopropyl betaine was purchased from basf (china) ltd; sodium cocoyl methyl taurate sodium taurate was purchased from Toho chemical (Shanghai) Co., Ltd; the acrylic acid (ester) copolymer is purchased from Luobo advanced materials company and has the product model number of
Figure BDA0003431146550000051
AQUA SF-1 POLYMER; hydroxypropyl starch phosphate was purchased from noreon chemicals (bosch) ltd; disodium EDTA is available from novuyon Chemicals (Ningbo) co., Ltd; herba Portulacae (Portulaca OLERACEA) extract is obtained from HYUNDAI BIOLAND CO., LTD; CI 42090 was purchased from Biotech, Inc., Nabinon, Guangzhou; CI 19140 was purchased from Nabinon, Guangzhou, Biotech, Inc.; octanoyl hydroxamic acid was purchased from eizhuo biotechnology, guangzhou, inc; phenoxyethanol was purchased from clariant chemical (china) ltd; fragrances were purchased from the Qihuadun daily perfumery (Shanghai) Co., Ltd.
Example 1A cleansing gel
A face cleaning jelly contains components shown in Table 1.
The preparation method of the face-cleaning jelly comprises the following steps:
(1) mixing glycerol, propylene glycol and acrylic acid (ester) cross-linked polymer, and stirring and wetting at normal temperature (20-30 ℃) to obtain phase A for later use;
(2) adding water, potassium cocoyl glycinate, sodium cocoyl methyl taurate and acrylic acid (ester) copolymer into a main pot, and stirring for dissolving to obtain a phase B;
(3) mixing disodium EDTA, triethanolamine, herba Portulacae (Portulaca OLERACEA) extract, CI 42090, CI 19140, caprylyl hydroxamic acid, phenoxyethanol and essence to obtain phase C, adding phase C into phase B under stirring at normal temperature (20-30 deg.C), mixing uniformly, and dissolving completely to obtain phase D;
(4) adding the phase A into the phase D at a constant speed under stirring at normal temperature (20-30 ℃), and slowly stirring until the paste is uniform;
(5) and (3) carrying out vacuum defoaming on the paste to obtain the face cleaning gel.
Table 1 ingredient content of cleansing gel of example 1
Figure BDA0003431146550000061
Example 2A cleansing gel
A face cleaning jelly contains components shown in Table 2.
The preparation method of the face-cleaning jelly comprises the following steps:
(1) mixing glycerol, propylene glycol and acrylic acid (ester) cross-linked polymer, and stirring and wetting at normal temperature (20-30 ℃) to obtain phase A for later use;
(2) adding water, potassium cocoyl glycinate, sodium cocoyl methyl taurate and hydroxypropyl starch phosphate into a main pot, and stirring for dissolving to obtain a phase B;
(3) mixing disodium EDTA, herba Portulacae (Portulaca OLERACEA) extract, CI 42090, CI 19140, caprylyl hydroxamic acid, phenoxyethanol and essence to obtain phase C, adding phase C into phase B under stirring at normal temperature (20-30 deg.C), mixing, and dissolving completely to obtain phase D;
(4) adding the phase A into the phase D at a constant speed under stirring at normal temperature (20-30 ℃), and slowly stirring until the paste is uniform;
(5) and (3) carrying out vacuum defoaming on the paste to obtain the face cleaning gel.
Table 2 ingredient content of cleansing gel of example 2
Figure BDA0003431146550000071
Example 3A cleansing gel
A face cleaning jelly contains components shown in Table 3.
The preparation method of the face-cleaning jelly comprises the following steps:
(1) mixing glycerol, propylene glycol and acrylic acid (ester) cross-linked polymer, and stirring and wetting at normal temperature (20-30 ℃) to obtain phase A for later use;
(2) adding water, sodium lauroyl sarcosinate, decyl glucoside and acrylic acid (ester) copolymer into a main pot, and stirring for dissolving to obtain a phase B;
(3) mixing disodium EDTA, triethanolamine, herba Portulacae (Portulaca OLERACEA) extract, CI 42090, CI 19140, caprylyl hydroxamic acid, phenoxyethanol and essence to obtain phase C, adding phase C into phase B under stirring at normal temperature (20-30 deg.C), mixing uniformly, and dissolving completely to obtain phase D;
(4) adding the phase A into the phase D at a constant speed under stirring at normal temperature (20-30 ℃), and slowly stirring until the paste is uniform;
(5) and (3) carrying out vacuum defoaming on the paste to obtain the face cleaning gel.
Table 3 ingredient content of cleansing gel of example 3
Figure BDA0003431146550000072
Figure BDA0003431146550000081
Example 4A cleansing gel
A face cleaning jelly contains components shown in Table 4.
The preparation method of the face-cleaning jelly comprises the following steps:
(1) mixing glycerol, butanediol and acrylic acid (ester) cross-linked polymer, and stirring and wetting at normal temperature (20-30 ℃) to obtain a phase A for later use;
(2) adding water, sodium lauroyl sarcosinate, decyl glucoside and hydroxypropyl starch phosphate into a main pot, and stirring for dissolving to obtain a phase B;
(3) mixing disodium EDTA, herba Portulacae (Portulaca OLERACEA) extract, CI 42090, CI 19140, caprylyl hydroxamic acid, phenoxyethanol and essence to obtain phase C, adding phase C into phase B under stirring at normal temperature (20-30 deg.C), mixing, and dissolving completely to obtain phase D;
(4) adding the phase A into the phase D at a constant speed under stirring at normal temperature (20-30 ℃), and slowly stirring until the paste is uniform;
(5) and (3) carrying out vacuum defoaming on the paste to obtain the face cleaning gel.
Table 4 ingredient content of cleansing gel of example 4
Figure BDA0003431146550000082
Figure BDA0003431146550000091
Example 5A cleansing gel
A face cleaning jelly contains the components shown in Table 5.
The preparation method of the face-cleaning jelly comprises the following steps:
(1) mixing glycerol, butanediol and acrylic acid (ester) cross-linked polymer, and stirring and wetting at normal temperature (20-30 ℃) to obtain a phase A for later use;
(2) adding water, potassium cocoyl glycinate, cocamidopropyl betaine and acrylic acid (ester) copolymer into a main pot, and stirring for dissolving to obtain a phase B;
(3) mixing disodium EDTA, triethanolamine, herba Portulacae (Portulaca OLERACEA) extract, CI 42090, CI 19140, caprylyl hydroxamic acid, phenoxyethanol and essence to obtain phase C, adding phase C into phase B under stirring at normal temperature (20-30 deg.C), mixing uniformly, and dissolving completely to obtain phase D;
(4) adding the phase A into the phase D at a constant speed under stirring at normal temperature (20-30 ℃), and slowly stirring until the paste is uniform;
(5) and (3) carrying out vacuum defoaming on the paste to obtain the face cleaning gel.
Table 5 ingredient content of cleansing gel of example 5
Figure BDA0003431146550000092
Example 6A cleansing gel
A facial gel having the same component content as the facial gel of example 1 except that: this example does not contain a crosslinked polymer of acrylic acid (ester) type, the missing mass fraction being made up by water.
Comparative example 1 soap-based facial cleanser
A soap-based facial cleanser has the component contents shown in Table 6.
The preparation method of the soap-based facial cleanser comprises the following steps:
(1) mixing polyethylene glycol-8, lauric acid, myristic acid, palmitic acid, stearic acid, glycerol stearate, PEG-100 stearate and glycerol hydroxystearate, heating to 80 deg.C until completely dissolved to obtain phase B;
(2) mixing water accounting for 3 percent (by weight) of the soap-based facial cleanser with polyquaternium-7 to obtain a phase C;
(3) mixing the rest water, EDTA disodium, glycerol and potassium hydroxide, dissolving, and heating to 78 deg.C to obtain phase A;
(4) slowly adding the phase A into the phase B, quickly stirring, dispersing soap groups, reducing the stirring speed after completely adding the phase A, saponifying for 60 minutes to obtain a phase E, and cooling;
(5) and cooling the phase E to 50-60 ℃, adding the phase C, mixing phenoxyethanol and essence to obtain a phase D, adding the phase D at 45 ℃, slowly stirring to 38 ℃, and discharging after the paste is completely soft and fine.
Table 6 component content of soap-based cleansing cream of comparative example 1
Figure BDA0003431146550000101
Comparative example 2 amino acid facial cleanser
The component contents of the amino acid facial cleanser are shown in Table 7.
Table 7 component content of amino acid facial cleanser of comparative example 2
Figure BDA0003431146550000102
Figure BDA0003431146550000111
The preparation method of the amino acid facial cleanser comprises the following steps:
(1) mixing water accounting for 3 wt% of the amino acid facial cleanser with acrylic acid (ester)/stearyl polyether-20 methacrylate copolymer, and stirring uniformly to obtain phase B;
(2) mixing the rest water, PEG-17 polydimethylsiloxane and EDTA disodium, adding into an emulsifying pot, heating to 80 ℃, stirring uniformly, and cooling to 60 ℃ to obtain phase A;
(3) adding phase B into phase A, adding p-hydroxyacetophenone (phase C), stirring and dissolving to obtain phase E;
(4) mixing 1, 2-hexanediol, sodium lauroyl sarcosinate, potassium cocoyl glycinate, disodium cocoyl glutamate, triethanolamine and essence to obtain phase D, cooling phase E to 45 deg.C, adding phase D, stirring and mixing;
(5) cooling to below 38 ℃, and vacuumizing and defoaming to obtain the amino acid facial cleanser.
Comparative example 3A pearlescent cleanser
The component contents of the pearlescent facial cleanser are shown in table 8.
Table 8 component content of pearl facial cleanser of comparative example 3
Figure BDA0003431146550000112
Figure BDA0003431146550000121
The preparation method of the pearlescent facial cleanser comprises the following steps:
(1) mixing water accounting for 10 percent (weight ratio) of the pearl facial cleanser with sodium chloride to obtain a phase B;
(2) mixing the rest water, PEG-150 distearate, sodium laureth sulfate, cocamide MEA, cocamidopropyl betaine, ethylene glycol distearate and disodium laureth sulfosuccinate, adding into an emulsifying pot, heating to 80 deg.C, stirring, and cooling to 60 deg.C to obtain phase A;
(3) adding the phase B into the phase A, and uniformly stirring to obtain a phase D;
(4) cooling the phase D to 45 ℃, adding the phase C, stirring and mixing uniformly;
(5) cooling to below 38 ℃, and vacuumizing and defoaming to obtain the pearlescent facial cleanser.
Effects of the embodiment
Effect example 1 hygiene index detection and stability test
According to the detection method in technical specifications for safety of cosmetics (2015), the total number of bacterial colonies, the total number of mold and yeast and staphylococcus aureus of the facial cleansing products prepared in examples 1 to 6 and comparative examples 1 to 3 of the present invention were detected. Meanwhile, stability tests are carried out on the cleansing products prepared in the examples 1 to 6 and the comparative examples 1 to 3, and the stability tests are as follows:
(1) and (3) heat resistance test: placing the sample in a thermostat at 48 +/-1 ℃ for 24 hours, and observing whether layering and discoloration phenomena occur or not after the temperature is recovered to the room temperature;
(2) cold resistance test: and (3) placing the sample in a constant temperature box at (-15 +/-1 ℃) for 24 hours, and observing whether layering, thickening and discoloration phenomena exist after the room temperature is recovered.
The results of the hygiene index test and the stability test are shown in table 9: the total number of colonies in the face cleaning products prepared in the examples 1-6 and the comparative examples 1-3 is less than or equal to 500CFU/g, the total number of moulds and yeasts is less than or equal to 100CFU/g, no staphylococcus aureus is detected, and the face cleaning jelly meets the national standard, so that the face cleaning jelly prepared in the examples 1-6 is good in safety and can be used by consumers at ease; meanwhile, the products of the examples 1-6 have no abnormal heat resistance and cold resistance, which shows that the facial cleansing jelly prepared in the examples 1-6 has high stability; whereas the soap-based cleansing cream of comparative example 1 showed a thickening phenomenon in the cold resistance test.
TABLE 9 sanitary index test and stability test results of the cleansing products prepared in examples 1 to 6 and comparative examples 1 to 3
Figure BDA0003431146550000122
Figure BDA0003431146550000131
Effect example 2 appearance comparative test
10 g of each of the face cleansing gels prepared in examples 1 to 6 was placed on a black base plate and photographed by a camera, and the results are shown in fig. 1: the cleansing gels of examples 1 to 5 were ice-slush gel-like in appearance, and the cleansing gel of example 6 was a generally transparent gel-like in that no acrylic crosslinked polymer was added as an excipient.
Effect example 3 sensory evaluation test
90 healthy skin volunteers were selected for sensory evaluation tests, 10 per group. Each face cleaning product is used for 1 week, and is respectively used for 1 time in the morning and evening, a subject scores according to the feeling in the using process, the average value of the final result is taken, the score is divided into 10 points, 1 point is the worst effect, 10 points are the best effect, and the test results are shown in a table 10: the cleansing gel of the embodiments 1-6 of the invention has moderate cleansing power and foam richness, is equivalent to the soap-based cleansing cream of the comparative example 1, and is superior to the amino acid cleansing milk of the comparative example 2 and the pearlescent cleansing milk of the comparative example 3; the cleansing gels of examples 1-6 have slightly less rinsability than the soap-based cleansing cream of comparative example 1, but better than the amino acid cleansing cream of comparative example 2; the mildness of the facial cleansing gel of the embodiments 1-6 is superior to that of the soap-based facial cleansing cream of the comparative example 1 and the pearl facial cleansing cream of the comparative example 3, and is equivalent to that of the amino acid facial cleansing cream of the comparative example 2; the dry and astringent feeling of the cleansing gel of the examples 1 to 6 after washing is better than that of the cleansing products of the comparative examples 1 to 3; namely, the cleansing gels of examples 1 to 6 have moderate cleansing power, abundant foam, easy rinsing and low irritation (mild and low dry feeling).
TABLE 10 sensory evaluation scores of the cleansing products prepared in examples 1 to 6 and comparative examples 1 to 3
Group of Cleaning power Richness of foam Washability of the agent Degree of mildness Dry and astringent after washing
Example 1 8.2 8.6 8.3 8.3 7.8
Example 2 8.5 8.8 8.7 8.0 7.2
Example 3 8.6 8.4 8.3 8.5 8.0
Example 4 8.3 7.8 8.5 8.8 8.4
Example 5 8.5 9.0 8.9 9.0 8.1
Example 6 8.1 8.0 8.3 8.4 7.7
Comparative example 1 8.8 8.3 9.5 4.3 3.6
Comparative example 2 5.6 6.0 5.2 8.7 5.9
Comparative example 3 6.5 6.9 8.6 6.7 6.8
Effect example 4 foaming ability test
The cleansing products prepared in examples 1 to 6 and comparative examples 1 to 3 were subjected to a foaming force test (each treatment was repeated 3 times) according to GB/T13173.6 "determination of foaming force of detergent" (Ross-Miles method), and the test results are shown in Table 11 (3 averaging, two significant figures retained): the initial foam height of the facial cleansing gels of examples 1-6 is equivalent to (even better than) that of the soap-based facial cleanser of comparative example 1, and is superior to the amino acid facial cleanser of comparative example 2 and the pearlescent facial cleanser of comparative example 3; the foam height after 5min is superior to the soap-based facial cleanser of comparative example 1, the amino acid facial cleanser of comparative example 2 and the pearlescent facial cleanser of comparative example 3, which shows that the facial cleansing gels of examples 1-6 have better foaming power.
TABLE 11 foaming force test results of the cleansing products prepared in examples 1 to 6 and comparative examples 1 to 3
Group of Initial foam height (mm) 5min foam height (mm)
Example 1 76 72
Example 2 83 76
Example 3 80 75
Example 4 74 68
Example 5 85 78
Example 6 74 72
Comparative example 1 76 62
Comparative example 2 58 36
Comparative example 3 63 45
Effect example 5 percutaneous Water loss test
Trans Epidermal Water Loss (TEWL), also known as transdermal Water Loss, represents the degree of Water Loss from the dermis by evaporation through the epidermis, and is an important parameter describing the barrier function of the skin, which is closely related to the Water content of the stratum corneum of the skin. The lower the TEWL value, the less water is lost through the skin, the better the barrier function of the stratum corneum; conversely, the poorer the barrier function. The test was carried out on the volunteers using the product using a moisture percutaneous loss tester (Tewameter TM 3000).
Randomly selecting 90 effective volunteers, wherein 45 male and female patients are selected, the age is 18-45 years (except for pregnant and lactating women), the tested part has no skin problem in the next month, no history of system diseases and no history of severe allergy to skin care products. Before testing, volunteers were asked to wipe both arms with clear water, sit still for 30 minutes in a constant temperature and humidity environment (temperature: 25. + -. 1 ℃ C., relative humidity: 40. + -. 5%) and to remain relaxed. A4 x 4cm test area is marked on the inner side of the arm of a volunteer 5cm away from the base of the palm, a plurality of areas (interval of 1cm) can be marked on the same arm at the same time, test examples and comparative examples are randomly distributed on the left arm and the right arm, and the marked areas can not be coated with medicines or cosmetics irrelevant to the experiment during the test. The same amount (2g) of samples are respectively used in the marking areas of the volunteers for 4 continuous weeks (the testing area of each volunteer is 9, each area of each volunteer fixedly uses one sample, and each person uses the samples for 1 time every day), and the samples are rubbed for the same number of turns to be washed clean and naturally dried. Before use, at week 1,The transdermal water loss values of the test area were measured and recorded using a Tewameter TM3000 at week 2 and week 4, respectively (TEWEL-W0、TEWEL-W1、TEWEL-W2、TEWEL-W4) And the change value Δ tewell after 4 weeks of use was calculated (tewell-W4)-(TEWEL-W0) The test results (average of the experimental data obtained) are shown in table 12: the higher the transdermal water dispersion loss of the volunteers with the increase of the test time, which indicates that different types of facial cleansing products can damage the skin barrier; as can be seen from Delta TEWEL, the facial gels of examples 1-6 of the present invention have a weaker effect on the skin barrier than the soap-based facial cleanser of comparative example 1 and the pearlescent facial cleanser of comparative example 3, and are close to the amino acid facial cleanser of comparative example 2, indicating that the mildness of the facial gels of examples 1-6 is close to that of the amino acid facial cleanser.
TABLE 12 results of tests on moisture loss through skin of cleansing products prepared in examples 1 to 6 and comparative examples 1 to 3
Figure BDA0003431146550000151
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (10)

1. A skin cleansing composition comprises the following components in parts by weight: 10-45 parts of amino acid surfactant, 3-12 parts of auxiliary surfactant, 1-5 parts of thickening suspending agent, 4-6 parts of humectant and 0-9 parts of excipient.
2. The skin cleansing composition according to claim 1, characterized by:
the skin cleaning composition comprises the following components in parts by weight: 15-40 parts of amino acid surfactant, 5-10 parts of auxiliary surfactant, 2-4 parts of thickening suspending agent, 4-5 parts of humectant and 6-7.5 parts of excipient.
3. The skin cleansing composition according to claim 1 or 2, characterized in that:
the amino acid surfactant is at least one of potassium cocoyl glycinate, sodium lauroyl sarcosinate, disodium cocoyl glutamate and sodium cocoyl glycinate.
4. The skin cleansing composition according to claim 1 or 2, characterized in that:
the auxiliary surfactant is at least one of sodium cocoyl methyl taurate, decyl glucoside, cocamidopropyl betaine, sodium lauroamphoacetate and sodium cocoyl isethionate.
5. The skin cleansing composition according to claim 1 or 2, characterized in that:
the excipient is at least one of acrylic acid (ester) cross-linked polymer and sodium polyacrylate.
6. The skin cleansing composition according to claim 1 or 2, characterized in that:
the thickening suspending agent is at least one of hydroxypropyl starch phosphate, acrylic acid (ester) copolymer and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer;
preferably, the humectant is at least one of glycerin, sorbitol, propylene glycol, dipropylene glycol, and butylene glycol.
7. Use of the skin cleansing composition according to any one of claims 1 to 6 for the preparation of a cosmetic.
8. The face-cleaning jelly comprises the following components in parts by weight: 18 to 77 parts of the skin cleansing composition according to any one of claims 1 to 6.
9. The cleansing gel according to claim 8, wherein:
the face-cleaning jelly also comprises the following components in parts by weight: 0.3-0.8 parts of a skin conditioner;
preferably, the cleansing gel further comprises the following components in parts by weight: 0.01-0.05 part of a chelating agent;
preferably, the cleansing gel further comprises the following components in parts by weight: 0.01-0.1 part of a coloring agent;
preferably, the cleansing gel further comprises the following components in parts by weight: 0.1-0.6 parts of an aromatic agent;
preferably, the cleansing gel further comprises the following components in parts by weight: 0.5-1.5 parts of a preservative;
preferably, the cleansing gel further comprises the following components in parts by weight: 0-1.0 part of a pH regulator;
preferably, the cleansing gel further comprises the following components in parts by weight: 45-65 parts of water.
10. The method of making cleansing gel according to claim 9, comprising the steps of:
mixing humectant with excipient to obtain phase A;
mixing an amino acid surfactant, an auxiliary surfactant, a thickening suspending agent and water to obtain a phase B;
mixing skin conditioner, chelating agent, pH regulator, colorant, and antiseptic to obtain phase C;
mixing the phase C with the phase B to obtain a phase D;
and mixing the phase D with the phase A to obtain the face cleaning gel.
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