CN108642142A - Cartridge component and hybridization instrument - Google Patents
Cartridge component and hybridization instrument Download PDFInfo
- Publication number
- CN108642142A CN108642142A CN201810592043.1A CN201810592043A CN108642142A CN 108642142 A CN108642142 A CN 108642142A CN 201810592043 A CN201810592043 A CN 201810592043A CN 108642142 A CN108642142 A CN 108642142A
- Authority
- CN
- China
- Prior art keywords
- cartridge
- reaction warehouse
- channel
- reaction
- department
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Abstract
The invention discloses cartridge component and hybridization instruments, are related to hybridization instrument technical field.Cartridge component provided by the invention includes the first cartridge, the second cartridge and reaction chip.First cartridge is provided with reaction warehouse, throws away channel and mounting portion, and reaction warehouse is connected to channel is thrown away, and reaction chip is set in reaction warehouse.Second cartridge is provided with adding mouth, form portion and department of assembly, adding mouth and is connected to reaction warehouse, and form portion is oppositely arranged with reaction warehouse, and department of assembly is set to the side in form portion and is supported with the side wall of reaction warehouse, and the second cartridge is covered in the first cartridge.The present invention also provides a kind of hybridization instruments including cartridge component.Cartridge component and hybridization instrument provided by the invention have the characteristics that simple in structure, easy to use and are convenient for observation, and can be convenient for the processing of waste liquid.
Description
Technical field
The present invention relates to hybridization instrument technical fields, in particular to cartridge component and hybridization instrument.
Background technology
Traditional micro-array biochip analysis system, it is several to generally comprise chip hybridization, cleaning, dyeing and detection etc.
Link, these links are had been manually done by operating personnel, are not only taken time and effort, but also manual operation can bring experimental error,
Polluted possibility.For this problem, scientific research personnel develops the micro- of a variety of different self-enclosed hybridization cleaning systems
Array chip structure, and dyeing integration system is cleaned in mating full-automatic hybridization for it, realizes the full-automation of operation.
However, current this system makes different reactions or cleaning solution pass through often by piping connection modules
It crosses pipeline and enters chip card box.Liquid passes in and out chip card box in addition to that can expend longer time by pipeline, leads to the total of detection
Time lengthening；Meanwhile by Pipe transfer, there is also occur to carry the possibility polluted；In addition, if pipeline selection is improper, very
The case where being susceptible to pipeline aging and leakage.
Invention content
The purpose of the present invention is to provide a kind of cartridge components, with simple in structure, easy to use and convenient for observation
Feature, and the processing of waste liquid can be convenient for.
The present invention provides a kind of technical solution about cartridge component：
A kind of cartridge component, including the first cartridge, the second cartridge and reaction chip.First cartridge is provided with reaction
Storehouse throws away channel and mounting portion, and the reaction warehouse is connected to the channel that throws away, and the reaction chip is set to the reaction warehouse
It is interior.Second cartridge is provided with adding mouth, form portion and department of assembly, and the adding mouth is connected to the reaction warehouse, described to regard
Window portion is oppositely arranged with the reaction warehouse, the department of assembly be set to the side in the form portion and with the side wall of the reaction warehouse
It supports, second cartridge is covered in first cartridge.
Further, the form portion towards the reaction warehouse direction projection and in second cartridge far from the reaction
The side in storehouse forms recessed portion.
Further, one end end set of the department of assembly far from second cartridge has seal face, the reaction core
Piece is set to the bottom wall of the reaction warehouse, and the seal face is supported with the reaction chip.
Further, one end end set of the department of assembly far from second cartridge has protrusion, the seal face to prolong
The protrusion is extended to, the side wall of the reaction warehouse is provided with the groove with the male cooperation.
Further, first cartridge is additionally provided with into channel, described to be connected into channel with the reaction warehouse, institute
State adding mouth with it is described enter channel it is opposite and with it is described entrance channel be connected to.
Further, the bottom surface into channel is obliquely installed towards the reaction warehouse, and the position of the mounting portion with
The position into channel is opposite.
Further, second cartridge is additionally provided with mark part, and the position of the mark part throws away channel phase with described
It is right.
Further, second cartridge is additionally provided with current limliting item, and the current limliting item is opposite with the position of the mark part,
The current limliting item throws away channel cooperation with described.
Further, the quantity of first cartridge and second cartridge is corresponding multiple, and multiple described the
One cartridge is sequentially connected.
Another object of the present invention is to provide a kind of hybridization instrument, with simple in structure, easy to use and convenient for observation
The characteristics of, and the processing of waste liquid can be convenient for.
The present invention also provides a kind of technical solutions about hybridization instrument：
A kind of hybridization instrument, including multiple cartridge components.Cartridge component, including the first cartridge, the second cartridge and reaction chip.
First cartridge is provided with reaction warehouse, throws away channel and mounting portion, and the reaction warehouse is connected to the channel that throws away, described anti-
Chip is answered to be set in the reaction warehouse.Second cartridge is provided with adding mouth, form portion and department of assembly, the adding mouth with
The reaction warehouse connection, the form portion are oppositely arranged with the reaction warehouse, and the department of assembly is set to the side in the form portion
The side wall of reaction warehouse described in Bian Bingyu supports, and second cartridge is covered in first cartridge.Multiple described first
Cartridge is sequentially connected.
Compared with prior art, the advantageous effect of cartridge component and hybridization instrument provided by the invention is：
The reaction warehouse of first cartridge setting is for housing reaction solution, and reaction chip is set in reaction warehouse, that is to say, that
Reaction warehouse provides the place of reaction.Second cartridge closes reaction warehouse for covering, and adding mouth is for reaction solution to be added into reaction warehouse.
Channel is thrown away under the influence of centrifugal force throwing away the waste liquid after reaction from channel is thrown away, and it is logical for miniflow to throw away channel
Road is also possible to prevent the reagent in reagent blending process and is thrown out of (centrifugal force is different).The effect in form portion is easy for observing,
Department of assembly is used for detachably connected with the first box body.Mounting portion is used to the first box body being installed on hybridization instrument.The present invention carries
The cartridge component and hybridization instrument of confession have the characteristics that simple in structure, easy to use and are convenient for observation, and can be convenient for the place of waste liquid
Reason.
Description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described.It should be appreciated that the following drawings illustrates only certain embodiments of the present invention, therefore it is not construed as pair
The restriction of range.It for those of ordinary skill in the art, without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is structural schematic diagram of the cartridge component that provides of the embodiment of the present invention under the first visual angle；
Fig. 2 is structural schematic diagram of the cartridge component that provides of the embodiment of the present invention under the second visual angle；
Fig. 3 is the decomposition texture schematic diagram for the cartridge component that the embodiment of the present invention provides；
Fig. 4 is the enlarged structure schematic diagram at IV in Fig. 2.
Icon：100- cartridge components；The first cartridges of 110-；112- reaction warehouses；114- throws away channel；116- mounting portions；
118- enters channel；The second cartridges of 120-；121- adding mouths；123- forms portion；The departments of assembly 125-；127- mark parts；128- is limited
Flow item；130- reaction chips.
Specific implementation mode
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described.Obviously, described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.The present invention being usually described and illustrated herein in the accompanying drawings is implemented
The component of example can be arranged and be designed with a variety of different configurations.
Therefore, below the detailed description of the embodiment of the present invention to providing in the accompanying drawings be not intended to limit it is claimed
The scope of the present invention, but be merely representative of the present invention selected embodiment.Based on the embodiments of the present invention, this field is common
The every other embodiment that technical staff is obtained without creative efforts belongs to the model that the present invention protects
It encloses.
It should be noted that：Similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined, then it further need not be defined and explained in subsequent attached drawing in a attached drawing.
In the description of the present invention, it is to be understood that, the instructions such as term "upper", "lower", "inner", "outside", "left", "right"
Orientation or positional relationship be based on the orientation or positional relationship shown in the drawings or the invention product using when usually put
Orientation or positional relationship or the orientation or positional relationship that usually understands of those skilled in the art, be merely for convenience of retouching
It states the present invention and simplifies description, do not indicate or imply the indicated equipment or element must have a particular orientation, with specific
Azimuth configuration and operation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " etc. are only used for distinguishing description, it is not understood to indicate or imply relatively important
Property.
In the description of the present invention, it is also necessary to which explanation is unless specifically defined or limited otherwise, " setting ", " even
Connect " etc. terms shall be understood in a broad sense, for example, " connection " may be a fixed connection, may be a detachable connection, or integrally connect
It connects；It can be mechanical connection, can also be electrical connection；Can be directly connected to, can also be indirectly connected with by intermediary, it can
To be the connection inside two elements.For the ordinary skill in the art, can understand as the case may be above-mentioned
The concrete meaning of term in the present invention.
Below in conjunction with the accompanying drawings, the specific implementation mode of the present invention is described in detail.
First embodiment
Fig. 1 to Fig. 4 is please referred to, a kind of cartridge component 100 is present embodiments provided, with simple in structure, use
The characteristics of conveniently and convenient for observation, and the processing of waste liquid can be convenient for.
It is to be appreciated that cartridge component 100 provided in this embodiment is for hybridization instrument, such as molecule hybridization, protein hybridization etc..
The effect of cartridge component 100 is to realize that the reaction chip 130 of setting in the inner is reacted.
Simultaneously, it is also desirable to illustrate, gene film chip detection method is for animal derived materials, pathogenic microorganisms, plant source
Property, the detection such as transgenosis and anaphylactogen composition etc..This method feature is：Simply, practical, quick, accurate, there is at low cost, inspection
The features such as surveying full index and naked eyes direct interpretation.The detection method can realize single react multiple determination, with regular-PCR method and
Fluorescence quantitative PCR method compares, and greatly reduces user's labor intensity and reduces detection time.The introducing of this method can carry
To the related scientific research such as food-borne plant, animal, pathogenic microorganisms level, the detectability to improving laboratory has for high functional department
Certain meaning.The reaction chip 130 that the present embodiment uses is membrane DNA chip, that is to say, that hybridization instrument energy provided in this embodiment
Enough implement gene film chip detection method.
Cartridge component 100 provided in this embodiment includes the first cartridge 110, the second cartridge 120 and reaction chip 130.The
One cartridge 110 is provided with reaction warehouse 112, throws away channel 114 and mounting portion 116, and reaction warehouse 112 is connected to channel 114 is thrown away, instead
Chip 130 is answered to be set in reaction warehouse 112.Second cartridge 120 is provided with adding mouth 121, form portion 123 and department of assembly 125, adds
Sample mouth 121 is connected to reaction warehouse 112, and form portion 123 is oppositely arranged with reaction warehouse 112, and department of assembly 125 is set to form portion 123
Side and supported with the side wall of reaction warehouse 112, the second cartridge 120 is covered in the first cartridge 110.
It is to be appreciated that the reaction warehouse 112 of the first cartridge 110 setting is used to house reaction solution, and reaction chip 130 is set to
In reaction warehouse 112, that is to say, that reaction warehouse 112 provides the place of reaction.Second cartridge 120 closes reaction warehouse 112 for covering,
Adding mouth 121 into reaction warehouse 112 for being added reaction solution.After channel 114 is thrown away for that will react under the influence of centrifugal force
Waste liquid thrown away from channel 114 is thrown away, and throw away channel 114 be microchannel, be also possible to prevent in reagent blending process
Middle reagent is thrown out of (centrifugal force is different).The effect in form portion 123 is easy for observing, and department of assembly 125 is used for can with the first box body
Releasably connect.Mounting portion 116 is used to the first box body being installed on hybridization instrument.
In the present embodiment, form portion 123 towards reaction warehouse 112 direction projection and in the second cartridge 120 far from reaction warehouse
112 side forms recessed portion.
That is, form portion 123 is to sink to being arranged, make to make in turn form portion 123 at a distance from 112 bottom surface of reaction warehouse more
Closely, such cleaning solution need not be full of reaction warehouse 112, it is only necessary to cleaning solution liquid level be made to be contacted with form sinking inner surface.
The setting of above-mentioned recessed portion can prevent 112 cleaning liquid inside of reaction warehouse to be easy to cause spilling too much.
In the present embodiment, one end end set of the department of assembly 125 far from the second cartridge 120 has seal face, reaction chip
130 are set to the bottom wall of reaction warehouse 112, and seal face is supported with reaction chip 130.
It is appreciated that reaction chip 130 is set on the bottom surface of reaction warehouse 112, by seal face to reaction chip 130 into
Row limit is fixed, to prevent reaction chip 130 from moving and throwing away.Meanwhile setting seal face can also make structure in department of assembly 125
Simpler, assembly is more convenient when using.
In the present embodiment, one end end set of the department of assembly 125 far from the second cartridge 120 has protrusion, seal face to extend
To protrusion, the side wall of reaction warehouse 112 is provided with the groove with male cooperation.
That is, department of assembly 125 is preferably engaged by clamping by protrusion and groove.Certainly, it is not limited to that,
In other embodiments of the invention, department of assembly 125 can also be matched by the size relationship between 112 side wall of reaction warehouse
It closes, for example the size of department of assembly 125 is slightly larger than the distance between 112 side wall of reaction warehouse, and then passes through the position of itself of department of assembly 125
Department of assembly 125 is held between the two side walls of reaction warehouse 112 by shifting.
In the present embodiment, the first cartridge 110 is additionally provided with into channel 118, is connected into channel 118 and reaction warehouse 112
Logical, adding mouth 121 is opposite with into channel 118 and is connected into channel 118.
Further, in the present embodiment, it is obliquely installed into the bottom surface in channel 118 towards reaction warehouse 112, and mounting portion
116 position is opposite with the position in channel 118 is entered.
In the present embodiment, the second cartridge 120 is additionally provided with mark part 127, the position of mark part 127 and throws away channel
114 is opposite.
It is to be appreciated that the effect of mark part 127 is in order to which mark is arranged, in order to being capable of automatic identification in image acquisition phase
Chip type in cartridge component 100, therefore 100 end of cartridge component provides the mark part that can be used for differentiating chip categories
127。
Optionally, the point sample of array format may be used in the setting of mark part 127, and each point sample can be divided into black, white two
Kind color, it is exactly 0,1 to correspond to for computer, and can pass through the concrete form of the point sample in image acquisition phase judges core
The type of piece.
In addition, English can also be arranged without the mark of bracket mother and number composition in the lower section of point sample mark, mainly use
In identification of the operating personnel to the reaction chip 130 of cartridge component 100.
The mark can use the paper with gum, then use printer point sample needed for its printout surface, alphabetical sum number
Word.The stickup of the mark personnel that can arrange production before consigning to client are quantitatively posted by type；It can also be by required mark
Client is consigned to together with cartridge, allows client according to oneself required stickup.
In the present embodiment, the second cartridge 120 is additionally provided with current limliting item 128, the position of current limliting item 128 and mark part 127
Relatively, current limliting item 128 coordinates with channel 114 is thrown away.
It is to be appreciated that current limliting item 128 coordinates with channel 114 is thrown away, to prevent the liquid thrown away from entering the first cartridge 110
Between the second cartridge 120 and splash situation, liquid splashes can be avoided using current limliting item 128, and make liquid only from
Throw away the outflow of channel 114.
In the present embodiment, the quantity of the first cartridge 110 and the second cartridge 120 is corresponding multiple, and multiple first
Cartridge 110 is sequentially connected.
It is to be appreciated that the connection between multiple first cartridges 110 both can be detachably connected, can be integrated into
Type can be removed when only needing one of them first cartridge 110 by way of being detachably connected；Multiple first
Cartridge 110 using integrally formed mode connect when, can regard manufacture material by shear or break disconnected mode carry out it is multiple
The separation of first cartridge 110.
Optionally, cartridge component 100 is all made of PS (polystyrene plastics) material and PS materials is made with transparency height
The characteristics of, the Image Acquisition of experimental result can be convenient for.
The advantageous effect of cartridge component 100 provided in this embodiment：The reaction warehouse 112 of first cartridge 110 setting is for holding
Reaction solution is set, and reaction chip 130 is set in reaction warehouse 112, that is to say, that reaction warehouse 112 provides the place of reaction.The
Two cartridges 120 close reaction warehouse 112 for covering, and adding mouth 121 into reaction warehouse 112 for being added reaction solution.Throw away the use of channel 114
In under the influence of centrifugal force throwing away the waste liquid after reaction from channel 114 is thrown away, and it is microchannel to throw away channel 114,
It is also possible to prevent the reagent in reagent blending process and is thrown out of (centrifugal force is different).The effect in form portion 123 is easy for observing,
Department of assembly 125 is used for detachably connected with the first box body.Mounting portion 116 is used to the first box body being installed on hybridization instrument.This
The cartridge component 100 that embodiment provides has the characteristics that simple in structure, easy to use and is convenient for observation, and can be convenient for waste liquid
Processing.
Second embodiment
Please refer to Fig. 1 to Fig. 4, present embodiments provide a kind of hybridization instrument, with simple in structure, easy to use and
The characteristics of convenient for observing, and the processing of waste liquid can be convenient for.
Hybridization instrument provided in this embodiment includes pedestal, the multiple cartridge components 100 of rotating disk and setting on the rotating pan.
Rotating disk is rotatably arranged on pedestal, and cartridge component 100 includes the first cartridge 110, the second cartridge 120 and reaction chip
130.First cartridge 110 is provided with reaction warehouse 112, throws away channel 114 and mounting portion 116, reaction warehouse 112 and throws away channel 114
Connection, reaction chip 130 are set in reaction warehouse 112.Second cartridge 120 is provided with adding mouth 121, form portion 123 and assembly
Portion 125, adding mouth 121 are connected to reaction warehouse 112, and form portion 123 is oppositely arranged with reaction warehouse 112, and department of assembly 125, which is set to, to be regarded
The side of window portion 123 is simultaneously supported with the side wall of reaction warehouse 112, and the second cartridge 120 is covered in the first cartridge 110.It is multiple
First cartridge 110 is sequentially connected.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of cartridge component, which is characterized in that including the first cartridge, the second cartridge and reaction chip；
First cartridge is provided with reaction warehouse, throws away channel and mounting portion, and the reaction warehouse is connected to the channel that throws away, institute
Reaction chip is stated to be set in the reaction warehouse；
Second cartridge is provided with adding mouth, form portion and department of assembly, and the adding mouth is connected to the reaction warehouse, described to regard
Window portion is oppositely arranged with the reaction warehouse, the department of assembly be set to the side in the form portion and with the side wall of the reaction warehouse
It supports, second cartridge is covered in first cartridge.
2. cartridge component according to claim 1, which is characterized in that direction projection of the form portion towards the reaction warehouse
And form recessed portion in side of second cartridge far from the reaction warehouse.
3. cartridge component according to claim 1, which is characterized in that the one end of the department of assembly far from second cartridge
End set has seal face, and the reaction chip is set to the bottom wall of the reaction warehouse, and the seal face reacts core with described
Piece supports.
4. cartridge component according to claim 3, which is characterized in that the one end of the department of assembly far from second cartridge
End set has protrusion, the seal face to extend to the protrusion, and the side wall of the reaction warehouse is provided with and the male cooperation
Groove.
5. cartridge component according to claim 1, which is characterized in that first cartridge is additionally provided with into channel, institute
It states and is connected into channel with the reaction warehouse, the adding mouth is opposite with the entrance channel and is connected into channel with described.
6. cartridge component according to claim 5, which is characterized in that incline towards the reaction warehouse bottom surface into channel
Tiltedly setting, and the position of the mounting portion is opposite with the position into channel.
7. cartridge component according to claim 1, which is characterized in that second cartridge is additionally provided with mark part, described
The position of mark part with described to throw away channel opposite.
8. cartridge component according to claim 7, which is characterized in that second cartridge is additionally provided with current limliting item, described
Current limliting item is opposite with the position of the mark part, and the current limliting item throws away channel cooperation with described.
9. the cartridge component according to any one of claim 1-8, which is characterized in that first cartridge and described
The quantity of two cartridges is corresponding multiple, and multiple first cartridges are sequentially connected.
10. a kind of hybridization instrument, which is characterized in that more including multiple cartridge components as described in any one of claim 1-9
A first cartridge is sequentially connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810592043.1A CN108642142A (en) | 2018-06-08 | 2018-06-08 | Cartridge component and hybridization instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810592043.1A CN108642142A (en) | 2018-06-08 | 2018-06-08 | Cartridge component and hybridization instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108642142A true CN108642142A (en) | 2018-10-12 |
Family
ID=63752215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810592043.1A Pending CN108642142A (en) | 2018-06-08 | 2018-06-08 | Cartridge component and hybridization instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108642142A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109576150A (en) * | 2018-12-29 | 2019-04-05 | 西南民族大学 | Membrane DNA chip hybridization instrument |
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| US6258593B1 (en) * | 1999-06-30 | 2001-07-10 | Agilent Technologies Inc. | Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber |
| CN2725302Y (en) * | 2004-09-07 | 2005-09-14 | 中国人民解放军第三军医大学 | Multipurpose biological macromolecule microarray chip hybridization instrument |
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