CN108640835A - 一种有机催化制备三醋酸甘油酯的方法 - Google Patents
一种有机催化制备三醋酸甘油酯的方法 Download PDFInfo
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- CN108640835A CN108640835A CN201810371100.3A CN201810371100A CN108640835A CN 108640835 A CN108640835 A CN 108640835A CN 201810371100 A CN201810371100 A CN 201810371100A CN 108640835 A CN108640835 A CN 108640835A
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- Prior art keywords
- glycerine
- acetic acid
- triacetyl glycerine
- catalyst
- amino
- Prior art date
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- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000006555 catalytic reaction Methods 0.000 title claims abstract description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 80
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 71
- 238000006243 chemical reaction Methods 0.000 claims abstract description 36
- 235000011187 glycerol Nutrition 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000003054 catalyst Substances 0.000 claims abstract description 17
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical class NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000032050 esterification Effects 0.000 claims abstract description 8
- 238000005886 esterification reaction Methods 0.000 claims abstract description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 33
- PYSJLPAOBIGQPK-UHFFFAOYSA-N 4-phenyl-1,3-thiazol-2-amine Chemical class S1C(N)=NC(C=2C=CC=CC=2)=C1 PYSJLPAOBIGQPK-UHFFFAOYSA-N 0.000 claims description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 10
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 4
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 3
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims description 3
- 229950003476 aminothiazole Drugs 0.000 claims 1
- 150000003851 azoles Chemical class 0.000 claims 1
- FSATURPVOMZWBY-UHFFFAOYSA-N n-thiophen-2-ylacetamide Chemical group CC(=O)NC1=CC=CS1 FSATURPVOMZWBY-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 9
- 239000001257 hydrogen Substances 0.000 abstract description 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 238000007086 side reaction Methods 0.000 abstract description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract description 2
- 238000010189 synthetic method Methods 0.000 abstract description 2
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 description 25
- 238000010992 reflux Methods 0.000 description 21
- 239000000047 product Substances 0.000 description 14
- 238000004821 distillation Methods 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 11
- 238000005292 vacuum distillation Methods 0.000 description 11
- 238000009835 boiling Methods 0.000 description 10
- 230000001105 regulatory effect Effects 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000002253 acid Substances 0.000 description 4
- 235000013773 glyceryl triacetate Nutrition 0.000 description 4
- UWAXMUSNRIUHRQ-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-1,3-thiazol-2-amine Chemical compound S1C(N)=NC(C=2C=C(Cl)C(Cl)=CC=2)=C1 UWAXMUSNRIUHRQ-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- WXPLRSVMGRAIGW-UHFFFAOYSA-N n-(1,3-thiazol-2-yl)acetamide Chemical class CC(=O)NC1=NC=CS1 WXPLRSVMGRAIGW-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000001087 glyceryl triacetate Substances 0.000 description 2
- 239000011964 heteropoly acid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229960002622 triacetin Drugs 0.000 description 2
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000002608 ionic liquid Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- -1 triacetin Ester Chemical class 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201810371100.3A CN108640835B (zh) | 2018-04-23 | 2018-04-23 | 一种有机催化制备三醋酸甘油酯的方法 |
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CN201810371100.3A CN108640835B (zh) | 2018-04-23 | 2018-04-23 | 一种有机催化制备三醋酸甘油酯的方法 |
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CN108640835A true CN108640835A (zh) | 2018-10-12 |
CN108640835B CN108640835B (zh) | 2020-08-21 |
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CN201810371100.3A Active CN108640835B (zh) | 2018-04-23 | 2018-04-23 | 一种有机催化制备三醋酸甘油酯的方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112961056A (zh) * | 2021-02-03 | 2021-06-15 | 江苏瑞佳化学有限公司 | 一种三醋酸甘油酯的制备方法及其应用 |
CN113648451A (zh) * | 2021-08-19 | 2021-11-16 | 青岛大学 | 一种新型α-氰基丙烯酸酯类医用粘合剂及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009095458A1 (de) * | 2008-01-31 | 2009-08-06 | Basf Se | VERFAHREN ZUR HERSTELLUNG VON ESTERN VON α, β-UNGESÄTTIGTEN CARBONSÄUREN |
CN107022069A (zh) * | 2017-04-27 | 2017-08-08 | 南京工业大学 | 一种利用仿生催化剂催化γ‑戊内酯开环聚合的方法 |
CN107200686A (zh) * | 2017-04-27 | 2017-09-26 | 南京工业大学 | 一种利用磷酸苯酯类仿生催化剂连续生产醋酸甘油酯的方法 |
-
2018
- 2018-04-23 CN CN201810371100.3A patent/CN108640835B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009095458A1 (de) * | 2008-01-31 | 2009-08-06 | Basf Se | VERFAHREN ZUR HERSTELLUNG VON ESTERN VON α, β-UNGESÄTTIGTEN CARBONSÄUREN |
CN107022069A (zh) * | 2017-04-27 | 2017-08-08 | 南京工业大学 | 一种利用仿生催化剂催化γ‑戊内酯开环聚合的方法 |
CN107200686A (zh) * | 2017-04-27 | 2017-09-26 | 南京工业大学 | 一种利用磷酸苯酯类仿生催化剂连续生产醋酸甘油酯的方法 |
Non-Patent Citations (1)
Title |
---|
张开诚等: "《化学实验教程》", 28 February 2018, 华中科技大学出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112961056A (zh) * | 2021-02-03 | 2021-06-15 | 江苏瑞佳化学有限公司 | 一种三醋酸甘油酯的制备方法及其应用 |
CN113648451A (zh) * | 2021-08-19 | 2021-11-16 | 青岛大学 | 一种新型α-氰基丙烯酸酯类医用粘合剂及其制备方法 |
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CN108640835B (zh) | 2020-08-21 |
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CB03 | Change of inventor or designer information |
Inventor after: Kang Peng Inventor after: Duan Jindian Inventor after: Shi Shengpeng Inventor after: Cai Tao Inventor after: Guo Kai Inventor after: Zhao Wanru Inventor after: Zhu Ning Inventor after: Fang Zheng Inventor after: Hu Xin Inventor after: Li Zhenjiang Inventor before: Guo Kai Inventor before: Zhao Wanru Inventor before: Zhu Ning Inventor before: Fang Zheng Inventor before: Hu Xin Inventor before: Li Zhenjiang Inventor before: Duan Jindian |
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Effective date of registration: 20220311 Address after: 100000 No. 22, Chaoyangmen North Street, Chaoyang District, Beijing Patentee after: CHINA PETROLEUM & CHEMICAL Corp. Address before: 210000 Puzhu South Road, Pukou District, Nanjing, Jiangsu 30 Patentee before: NANJING University OF TECHNOLOGY |
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