CN108633888A - A kind of sodium dichloroisocyanuratepowder powder and preparation method thereof - Google Patents
A kind of sodium dichloroisocyanuratepowder powder and preparation method thereof Download PDFInfo
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- CN108633888A CN108633888A CN201810617625.0A CN201810617625A CN108633888A CN 108633888 A CN108633888 A CN 108633888A CN 201810617625 A CN201810617625 A CN 201810617625A CN 108633888 A CN108633888 A CN 108633888A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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Abstract
The invention belongs to disinfectant fields, and in particular to a kind of sodium dichloroisocyanuratepowder powder and preparation method thereof.The sodium dichloroisocyanuratepowder powder includes following raw material and its parts by weight：47 60 parts of 40 50 parts of sodium dichloroisocyanurate, 0.2 1.0 parts of calgon, 0.5 2 parts of lauryl sodium sulfate and sodium sulphate.The sodium dichloroisocyanuratepowder powder aqueous solution can keep pH between 5.0 6.0, reduce the ionization of HClO, improve stability of solution, keep best disinfection effect, corrosion of the sodium dichloroisocyanurate solution to metal product can also be reduced simultaneously, it can 100% killing high-pathogenicity blue ear disease virus, swine fever virus and foot and mouth disease virus.
Description
Technical field
The invention belongs to disinfectant fields, and in particular to a kind of sodium dichloroisocyanuratepowder powder and preparation method thereof.
Background technology
Sodium dichloroisocyanurate be it is a kind of efficiently, wide spectrum, novel systemic fungicide, various bacteriums, algae, true can be killed
Bacterium and germ.Its chemical property is stablized, safe to use, easy, dosage is few, duration of efficacy is long convenient for storage transport, effect
Mechanism is：Sodium dichloroisocyanuratepowder powder is soluble in water slowly to discharge hypochlorous acid (HClO), and hypochlorous acid has excellent kill livestock
Effect changes membrane permeability, interferes enzyme system Physiology and biochemistry and influence DNA synthesis by making the protein denaturation of microorganism
Etc. processes, keep microorganism dead rapidly.
Chinese patent application CN101461363A discloses a kind of Youlvjing disinfecting agent and its application, the disinfectant are main
It is formed by sodium dichloroisocyanurate, ethanedioic acid, potassium permanganate, rosin, precipitated calcium carbonate, sodium acetate and auxiliary material mixed preparing.It should
Disinfectant can not only carry out disinfection to environment and various objects processing, moreover it is possible to carry out sootiness to room air and body surface and disappear
Poison processing, have it is simple for process, Disinfection Effect is reliable, remarkable advantage easy to operate.But it is molten after aqueous solution is made in the disinfectant
HClO in liquid is extremely unstable, works as pH>When 6.5, H can be ionized into+With ClO-, bactericidal effect is only the 1-2% of HClO, significantly
Reduce bactericidal effect.
Chinese patent application CN101897335A discloses a kind of sodium dichloroisocyanuratepowder powder, the sodium dichloroisocyanurate
Powder is made of sodium dichloroisocyanurate 18-22%, sodium tripolyphosphate 0.9-1.1%, sodium metasilicate 1.5-2% and surplus auxiliary material.Its
In, sodium tripolyphosphate can be such that sodium dichloroisocyanurate is acted under optimal acidity condition, reach highest as pH buffer
Killing germ effect；Auxiliary agent sodium metasilicate can improve the stability of product simultaneously.But after sodium dichloroisocyanuratepowder powder is dissolved in water
With strong oxidizing property, acidity and high concentration anionic so that sodium dichloroisocyanurate solution has very strong corrosivity to metal, no
It can be used for the disinfection of metal product, limit the use of sodium dichloroisocyanuratepowder powder.
Therefore, there is an urgent need to one kind to keep pH value of solution between 5.0-6.0, and stability is good, and disinfection effect is notable,
Reduce the sodium dichloroisocyanuratepowder powder to metal protection.
Invention content
The present invention is intended to provide a kind of sodium dichloroisocyanuratepowder powder and preparation method thereof.The sodium dichloroisocyanuratepowder powder water
Solution can keep pH between 5.0-6.0, reduce the ionization of HClO, improve stability of solution, best sterilizing is kept to imitate
Fruit, while corrosion of the sodium dichloroisocyanurate solution to metal product can also be reduced.
In order to achieve the above object, the present invention uses following technical scheme：
A kind of sodium dichloroisocyanuratepowder powder, including following raw material and its parts by weight：40-50 parts of sodium dichloroisocyanurate,
47-60 parts of 0.2-1.0 parts of calgon, 0.5-2 parts of lauryl sodium sulfate and sodium sulphate.
Further, the sodium dichloroisocyanuratepowder powder includes following raw material and its parts by weight：Sodium dichloroisocyanurate
53 parts of 45 parts, 0.5 part of calgon, 1.5 parts of lauryl sodium sulfate and sodium sulphate.
Further, the preparation of the sodium dichloroisocyanuratepowder powder includes the following steps：
S1, calgon, lauryl sodium sulfate and sodium sulphate are respectively placed in baking oven, 100-120 DEG C of drying, powder
It is broken, 50 mesh sieve is crossed, sodium dichloroisocyanurate crosses 50 mesh sieve, and powder is spare；
S2, the calgon for taking corresponding parts by weight and lauryl sodium sulfate powder, are added corresponding parts by weight two
/ mono- sodium sulphate is uniformly mixed, obtains mixture A；
S3, it takes the sodium dichloroisocyanurate of corresponding parts by weight that mixture A obtained by step S2 is added, is uniformly mixed, then add
Enter the sodium sulphate of other half, be uniformly mixed, dispense after the assay was approved to get.
In addition, the application the present invention also provides a kind of sodium dichloroisocyanuratepowder powder in disinfection field, the dichloro are different
Cyanurate sodium powder can be used for 100% killing high-pathogenicity blue ear disease virus, swine fever virus and foot and mouth disease virus.
Further, the sodium dichloroisocyanuratepowder powder kills high-pathogenicity blue ear disease virus and hog cholera for 100%
The highest aqueous solution extension rate of poison is 1:10000.
Further, the sodium dichloroisocyanuratepowder powder is dilute for the highest aqueous solution of 100% killing foot and mouth disease virus
It is 1 to release multiple:3200.
In addition, the application the present invention also provides a kind of sodium dichloroisocyanuratepowder powder in disinfection field, the dichloro are different
Cyanurate sodium powder can be used for 100% killing escherichia coli, staphylococcus aureus and Pasteurella.
Further, the sodium dichloroisocyanuratepowder powder kills escherichia coli, staphylococcus aureus for 100%
Highest aqueous solution extension rate with Pasteurella is 1:10000.
In addition, the present invention also provides a kind of preparation method of sodium dichloroisocyanuratepowder powder, the preparation method includes
Following steps：
S1, calgon, lauryl sodium sulfate and sodium sulphate are respectively placed in baking oven, 100-120 DEG C of drying, powder
It is broken, 50 mesh sieve is crossed, sodium dichloroisocyanurate crosses 50 mesh sieve, and powder is spare；
S2, the calgon for taking corresponding parts by weight and lauryl sodium sulfate powder, are added corresponding parts by weight two
/ mono- sodium sulphate is uniformly mixed, obtains mixture A；
S3, it takes the sodium dichloroisocyanurate of corresponding parts by weight that mixture A obtained by step S2 is added, is uniformly mixed, then add
Enter the sodium sulphate of other half, be uniformly mixed, dispense after the assay was approved to get.
In the present invention, lauryl sodium sulfate can reduce sodium dichloroisocyanurate solution corrosivity, applicant
It is found surprisingly that, after calgon is added, the component of sodium dichloroisocyanurate solution interacts, notable to corrosion of metal
It reduces.Test example 2 it can be proved that the 0.1% sodium dichloroisocyanurate solution for preparing of the present invention to stainless steel substrates, carbon steel coupon, aluminium
Piece and copper sheet is corrosion-free or no corrosion effect, and comparative example 1 (removing calgon) and comparative example 2 (remove dodecane
Base sodium sulphate) prepare 0.1% sodium dichloroisocyanurate solution have to stainless steel substrates, aluminium flake, carbon steel coupon and copper sheet it is different
The corrosiveness of degree.Its principle may be during sterilizing, and lauryl sodium sulfate is adsorbed in metal surface, with
Competitive Adsorption occurs for the chlorion in solution so that the destruction of chlorion weakens；Calgon can with chelated mineral from
Son collectively covers in metal surface with lauryl sodium sulfate, forms layer protecting film, resists strong oxidizing property, acidity and highly concentrated
Spend the corrosiveness of anion solutions.
Meanwhile calgon sodium dichloroisocyanuratepowder powder can be made to be dissolved in water after the pH value of solution that is formed be maintained at 5.0-
Between 6.0, to reduce the ionization of HClO in solution, the stability of solution is improved, keeps it in best sterilizing
State.Test example 1 is remarkably improved sterilizing rate to 100% it can be proved that calgon is added in the embodiment of the present invention 1, and three
Although polyphosphate sodium also has the ability of certain adjusting pH, so that pH value of solution is between 6.0-6.5, dichloro isocyanide urea can not be made
Acid sodium solution sterilizing rate reaches 100%.
In addition, the pleasantly surprised discovery of present invention applicant, each group distribution ratio of the present invention is reasonable, can kill various bacteria and disease
Poison.Test example 1 is it can be proved that sodium dichloroisocyanuratepowder powder of the present invention 100% kills escherichia coli, staphylococcus aureus
Highest dilution with Pasteurella is 1:10000；Test example 3-5 is it can be proved that sodium dichloroisocyanuratepowder powder of the present invention 100%
The highest diluted concentration for killing pathogenic reproductive and respiratory syndrome virus and swine fever virus is 1:10000,100% kills foot and mouth disease virus most
High dilution is 1:3200.
The present invention has the following advantages：
(1) aqueous solution prepared by sodium dichloroisocyanuratepowder powder of the present invention can keep pH between 5.0-6.0, reduce HClO's
Ionization improves stability of solution, keeps best disinfection effect.
(2) 0.1% aqueous solution prepared by sodium dichloroisocyanuratepowder powder of the present invention acts on metal no corrosion, low dense
Degree dilution can be used for the sterilizing of metal product.
(3) sodium dichloroisocyanuratepowder powder extension rate of the present invention is 1:10000 and its it is following when, can 100% kill large intestine
Escherichia, staphylococcus aureus, Pasteurella, pathogenic reproductive and respiratory syndrome virus and swine fever virus；Extension rate is 1:3200
It, can 100% killing foot and mouth disease virus virus and its when following.
Specific implementation mode
The specific implementation mode of form by the following examples makees further specifically the above of the present invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
Wherein agents useful for same is common agents, can be bought in reagent manufacturing enterprise.
Embodiment 1-3 sodium dichloroisocyanuratepowder powders
Sodium dichloroisocyanuratepowder powder raw material and its parts by weight described in 1-3 of the embodiment of the present invention are as shown in table 1.
Sodium dichloroisocyanuratepowder powder raw material and its parts by weight described in 1 1-3 of the embodiment of the present invention of table
| Material name | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Sodium dichloroisocyanurate | 45 | 40 | 48 |
| Calgon | 0.5 | 1.0 | 0.8 |
| Lauryl sodium sulfate | 1.5 | 1.0 | 1.2 |
| Sodium sulphate | 53 | 58 | 50 |
Preparation method：
S1, calgon, lauryl sodium sulfate and sodium sulphate being respectively placed in baking oven, 105 DEG C of drying crush,
50 mesh sieve is crossed, sodium dichloroisocyanurate crosses 50 mesh sieve, and powder is spare；
S2, the calgon for taking corresponding parts by weight and lauryl sodium sulfate powder, are added corresponding parts by weight two
/ mono- sodium sulphate is uniformly mixed, obtains mixture A；
S3, it takes the sodium dichloroisocyanurate of corresponding parts by weight that mixture A obtained by step S2 is added, is uniformly mixed, then add
Enter the sodium sulphate of other half, be uniformly mixed, dispense after the assay was approved to get.
1 sodium dichloroisocyanuratepowder powder of comparative example
Difference from Example 1 is that comparative example 1 removes calgon, and the dosage of sodium sulphate increases to 53.5 parts,
Remaining component and preparation method reference implementation example 1.
2 sodium dichloroisocyanuratepowder powder of comparative example
Difference from Example 1 is that comparative example 2 removes lauryl sodium sulfate, and the dosage of sodium sulphate increases to
54.5 parts, remaining component and preparation method reference implementation example 1.
3 sodium dichloroisocyanuratepowder powder of comparative example
Difference from Example 1 is that calgon is replaced with sodium tripolyphosphate by comparative example 3, remaining component and
Preparation method reference implementation example 1.
4 sodium dichloroisocyanuratepowder powder of comparative example
Difference from Example 1 is that lauryl sodium sulfate is replaced with neopelex by comparative example 4,
Remaining component and preparation method reference implementation example 1.
1 pH value of solution of test example and disinfection effect measure
1. test material：Sodium dichloroisocyanuratepowder powder prepared by embodiment 1, comparative example 1 and comparative example 3.
2. subjects：Escherichia coli (8099), staphylococcus aureus (ATCC6538) and Pasteurella, are purchased
Institute is supervised from Chinese animal doctor's veterinary medicament.
3. test method：Bacterium solution is subjected to count plate, is then diluted to containing bacterium 10 with sodium chloride injection6-107CFU/
The test bacteria liquid of ml, sodium dichloroisocyanuratepowder powder prepared by embodiment 1, comparative example 1 and comparative example 3 are dilute by specified dilution ratio
It releases to test concentrations, draws 0.5ml test bacteria liquids in the sodium dichloroisocyanurate solution of 4.5ml test concentrations, set 20 DEG C of water
After acting on 5min in bath, 1.0ml is drawn immediately, 9.0ml neutralizers are added (containing 0.5% sodium thiosulfate, 0.3% lecithin, 2%
The phosphate buffer of Tween 80,1% tryptone, pH7.2-7.4, in 121 DEG C of pressuresteam sterilization 20min) in mixing, with
0.9% sodium chloride injection calculates each group bacterium and is averaged killing rate as blank control.
4. test result：
2 sodium dichloroisocyanuratepowder powder pH value of solution of table and bactericidal effect
As shown in Table 2, the sodium dichloroisocyanuratepowder powder pH value of solution that prepared by embodiment 1 is 6.0 hereinafter, being conducive in solution
Hypochlorous acid keeps stablizing, and so that sodium dichloroisocyanuratepowder powder is played maximum bactericidal effect, 1:(1000-10000) extension rate
Under the conditions of be 100% to the killing rate of escherichia coli, staphylococcus aureus and Pasteurella.And comparative example 1 is (partially without six
Sodium phosphate) for sodium dichloroisocyanurate dilution pH more than 7, hypochlorous acid is easy ionization, and sterilizing rate significantly reduces 13.8-29.6%；
Comparative example 3 (substituting calgon with sodium tripolyphosphate) sodium dichloroisocyanurate dilution pH is larger, sodium dichloroisocyanurate
Best bactericidal effect cannot be reached.
2 metal protection of test example measures
1. test material：Sodium dichloroisocyanuratepowder powder prepared by embodiment 1, comparative example 1-4.
2. subjects：Stainless steel substrates, carbon steel coupon, aluminium flake and copper sheet.
3. test method：Reference《Disinfection technology standard》(version in 2002) carries out metal protection experiment.
Classification of 3 disinfectant of table to metal erosion
| R0<0.005 | It is corrosion-free |
| 0.005≤R1<0.010 | No corrosion |
| 0.010≤R2<0.100 | Mild corrosion |
| 0.100≤R3<1.000 | Moderate corrosion |
| R4≥1.000 | Severe is corroded |
4. test result：
4 0.1% sodium dichloroisocyanurate solution corrosivity test result of table
As shown in Table 4, the 0.1% sodium dichloroisocyanurate solution that prepared by the embodiment of the present invention 1 is corrosion-free to stainless steel substrates
Effect, to carbon steel coupon, aluminium flake and copper sheet no corrosion act on, illustrate sodium dichloroisocyanuratepowder powder of the present invention can less than or equal to
The disinfection of metal is used in 0.1% concentration range.And comparative example 1 (no calgon) and 3 (hexa metaphosphoric acid of comparative example
Sodium replaces with sodium tripolyphosphate) prepare 0.1% sodium dichloroisocyanurate solution have mild corrosion work to stainless steel substrates and aluminium flake
With having moderate corrosion effect to carbon steel coupon and copper sheet；Comparative example 2 (no lauryl sodium sulfate) and (the dodecyl sulphur of comparative example 4
Sour sodium replaces with neopelex) 0.01% sodium dichloroisocyanurate solution for preparing has stainless steel substrates and aluminium flake
Corrosiveness is spent, has severe corrosiveness to carbon steel coupon and copper sheet, illustrates 0.1% dichloroisocyanuric acid prepared by comparative example 1-4
Sodium solution can cause metal erosion, not be suitable for the sterilizing of metal product.
Effect of 3 sodium dichloroisocyanuratepowder powder of the present invention of test example to reproductive and respiratory syndrome virus
1. test material：Sodium dichloroisocyanuratepowder powder prepared by embodiment 1.
2. subjects：High-pathogenicity blue ear disease virus (PRRSV), MK cells Marc-145, by Ministry of Agriculture's animal epidemic disease
Sick prevention and control emphasis open laboratory provides.
3. test method：
(1) Marc-145 cells test the sensitivity of sodium dichloroisocyanuratepowder powder：By sodium dichloroisocyanuratepowder powder with 3%
FBS is diluted to different concentration, is inoculated in the corresponding aperture of cell respectively, per hole 1ml, is inoculated with 4 holes, is control with 3%FBS
Group is placed in 37 DEG C, 5%CO2It is cultivated in incubator, observes daily, continuously cultivate 5-7d, this experiment is repeated 3 times.The result shows that
3%FBS cellular control unit normal growths are thin to Marc-145 when sodium dichloroisocyanuratepowder powder concentration is less than or equal to 0.001%
The growth of born of the same parents has no significant effect.
(2) sodium dichloroisocyanuratepowder powder is killed PRRSV and is tested：Sodium dichloroisocyanuratepowder powder is diluted to difference with DMEM
Concentration, PRRSV stostes (TCID50=104.2/ 0.1ml) dilute the sodium dichloroisocyanurate solution with equivalent various concentration after 2 times
Mixing, 20 DEG C of effect 20min, then respectively 10 are diluted with 3%FBS3Times, it is linked into Marc-145 cell culture plate wells, each
4 holes of concentration, using 3%FBS as blank control group, 0.001% sodium dichloroisocyanurate solution be negative control group, 2 × 103Times
PRRSV liquid after dilution is positive control, is placed in 37 DEG C, 5%CO2It cultivates in incubator, observes daily.Continuous culture 5-7d,
Record cell growth status.
4. test result：
5 sodium dichloroisocyanuratepowder powder of table is to PRRSV killing effects
Note：* cell growth status is expressed as：Cell growth abnormity hole count/inoculation hole count.
As shown in Table 5, the solution that prepared by sodium dichloroisocyanuratepowder powder of the present invention can when more than or equal to 0.01% concentration
PRRSV viruses are killed, Marc-145 cells is made not to be infected by the virus, do not generate cytopathy, it can normal growth.Blank control group
With negative control group cell can normal growth, positive controls cell is infected, and growth failure (vacuole, melt by circle contracting
Close, fall off), illustrate that this experimental result data is reliable.
Effect of 4 sodium dichloroisocyanuratepowder powder of the present invention of test example to swine fever virus
1. test material：Sodium dichloroisocyanuratepowder powder prepared by embodiment 1.
2. subjects：Swine fever virus (HCV), porcine kidney cell (PK-15) are opened by Ministry of Agriculture's Field of Animal Epidemic Disease Control emphasis
Laboratory provides.
3. test method：
(1) PK-15 cells test the sensitivity of sodium dichloroisocyanuratepowder powder：By sodium dichloroisocyanuratepowder powder 3%FBS
It is diluted to different concentration, is inoculated in the corresponding aperture of cell respectively, per hole 1ml, is inoculated with 4 holes, using 3%FBS as control group,
37 DEG C are placed in, 5%CO2It is cultivated in incubator, observes daily, continuously cultivate 5-7d, this experiment is repeated 3 times.The result shows that 3%
FBS cellular control unit normal growths, when sodium dichloroisocyanuratepowder powder concentration is less than or equal to 0.001%, the life to PK-15 cells
Length has no significant effect.
(2) sodium dichloroisocyanuratepowder powder is killed HCV and is tested：Sodium dichloroisocyanuratepowder powder is diluted to DMEM different dense
Degree, HCV stostes (TCID50=104.2/ 0.1ml) dilution 2 times after mixed with the sodium dichloroisocyanurate solution of equivalent various concentration,
20 DEG C of effect 20min, then respectively 10 are diluted with 3%FBS3Times, it is linked into PK-15 cell culture plate wells, each concentration 4
Hole, using 3%FBS as blank control group, 0.001% sodium dichloroisocyanurate solution be negative control group, 2 × 103After diluting again
HCV liquid be positive control, be placed in 37 DEG C, 5%CO2It cultivates in incubator, observes daily.Continuous culture 5-7d, records cell
Growing state.
4. test result：
6 sodium dichloroisocyanuratepowder powder of table is to HCV killing effects
Note：*Cell growth status is expressed as：Cell growth abnormity hole count/inoculation hole count.
As shown in Table 6, the solution that prepared by sodium dichloroisocyanuratepowder powder of the present invention can when more than or equal to 0.01% concentration
HCV virus is killed, PK-15 cells is made not to be infected by the virus, does not generate cytopathy, it can normal growth.Blank control group and the moon
Property cellular control unit can normal growth, positive controls cell is infected, growth failure (circle contracting, vacuole, fusion,
Fall off), illustrate that this experimental result data is reliable.
Effect of 5 sodium dichloroisocyanuratepowder powder of the present invention of test example to foot and mouth disease virus
1. test material：Sodium dichloroisocyanuratepowder powder prepared by embodiment 1.
2. subjects：O-shaped aftosa suckling mouse tissue virus (LD50=10-8.0), 4 ages in days suck the breast small white mouse (suckling mouse), by
Field of Animal Epidemic Disease Control emphasis open laboratory of the Ministry of Agriculture provides.
3. test method：
(1) safety testing：Sodium dichloroisocyanuratepowder powder is done 1 with deionized water:100、1:200、1:300 and 1:400
It times dilutes, injects 4 age in days suckling mouses respectively, every suckling mouse dorsal sc injection 0.2ml sodium dichloroisocyanuratepowder powder dilution, every group
Injection 5, using deionized water as negative control.72h is observed continuously after injection, every group of experiment is repeated 4 times.The result shows that dichloro
Isocyanuric acid sodium powder is 1:300 times or more when diluting, to experimental animal safety.
(2) sodium dichloroisocyanuratepowder powder is killed foot and mouth disease virus and is tested：With deionized water by sodium dichloroisocyanuratepowder powder
Dilution 1:1000、1:1200、1:1400、1:1500、1:1600、1:1700 and 1:1800 times, respectively with dilution 1:500 times of mouth
Aphtovirus mixed in equal amounts, after room temperature acts on 30min, in 4 age in days suckling mouse dorsal sc injection viruses-thimerosal mixed liquor
0.2ml, using aliquots of deionized water as blank control group, 1:2000 sodium dichloroisocyanurate dilutions be negative control group, 1:
1000 times of diluted virus liquids are positive controls, and 7d is observed continuously in every group 54 age in days suckling mouses after injection, record mouse survival
Situation.
4. test result：
7 sodium dichloroisocyanuratepowder powder of table is to foot and mouth disease virus killing effect
Note：*Death rate is expressed as：Death toll/experimental animal sum.
As shown in Table 7, the highest dilution that sodium dichloroisocyanuratepowder powder 100% of the present invention kills foot and mouth disease virus is 1:
3200, suckling mouse can be made not to be infected by the virus, it can normal growth and development.Blank control group and negative control group suckling mouse can normally give birth to
Development, positive controls suckling mouse are infected, cause animal dead, illustrate that this experimental result data is reliable.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should by the present invention claim be covered.
Claims (9)
1. a kind of sodium dichloroisocyanuratepowder powder, which is characterized in that including following raw material and its parts by weight：Sodium dichloroisocyanurate
47-60 parts of 40-50 parts, 0.2-1.0 parts of calgon, 0.5-2 parts of lauryl sodium sulfate and sodium sulphate.
2. sodium dichloroisocyanuratepowder powder as described in claim 1, which is characterized in that including following raw material and its parts by weight：Two
53 parts of 45 parts of chlorine isocyanuric acid sodium, 0.5 part of calgon, 1.5 parts of lauryl sodium sulfate and sodium sulphate.
3. sodium dichloroisocyanuratepowder powder as claimed in claim 1 or 2, which is characterized in that the system of the sodium dichloroisocyanuratepowder powder
It is standby to include the following steps：
S1, calgon, lauryl sodium sulfate and sodium sulphate being respectively placed in baking oven, 100-120 DEG C of drying crushes,
50 mesh sieve is crossed, sodium dichloroisocyanurate crosses 50 mesh sieve, and powder is spare；
S2, the calgon for taking corresponding parts by weight and lauryl sodium sulfate powder, be added corresponding parts by weight two/
One sodium sulphate is uniformly mixed, obtains mixture A；
S3, it takes the sodium dichloroisocyanurate of corresponding parts by weight that mixture A obtained by step S2 is added, is uniformly mixed, add another
The sodium sulphate of outer half, be uniformly mixed, dispense after the assay was approved to get.
4. a kind of sodium dichloroisocyanuratepowder powder is in the application in disinfection field, which is characterized in that the sodium dichloroisocyanuratepowder powder can
High-pathogenicity blue ear disease virus, swine fever virus and foot and mouth disease virus are killed for 100%.
5. sodium dichloroisocyanuratepowder powder as claimed in claim 4 is in the application in disinfection field, which is characterized in that the dichloro isocyanide
The highest aqueous solution extension rate that urea acid sodium powder kills high-pathogenicity blue ear disease virus and swine fever virus for 100% is 1:
10000。
6. sodium dichloroisocyanuratepowder powder as claimed in claim 4 is in the application in disinfection field, which is characterized in that the dichloro isocyanide
The highest aqueous solution extension rate that urea acid sodium powder kills foot and mouth disease virus for 100% is 1:3200.
7. a kind of sodium dichloroisocyanuratepowder powder is in the application in disinfection field, which is characterized in that the sodium dichloroisocyanuratepowder powder can
Escherichia coli, staphylococcus aureus and Pasteurella are killed for 100%.
8. sodium dichloroisocyanuratepowder powder as claimed in claim 7 is in the application in disinfection field, which is characterized in that the dichloro isocyanide
The highest aqueous solution dilution times that urea acid sodium powder kills escherichia coli, staphylococcus aureus and Pasteurella for 100%
Number is 1:10000.
9. a kind of preparation method of sodium dichloroisocyanuratepowder powder, which is characterized in that the preparation method comprises the following steps：
S1, calgon, lauryl sodium sulfate and sodium sulphate being respectively placed in baking oven, 100-120 DEG C of drying crushes,
50 mesh sieve is crossed, sodium dichloroisocyanurate crosses 50 mesh sieve, and powder is spare；
S2, the calgon for taking corresponding parts by weight and lauryl sodium sulfate powder, be added corresponding parts by weight two/
One sodium sulphate is uniformly mixed, obtains mixture A；
S3, it takes the sodium dichloroisocyanurate of corresponding parts by weight that mixture A obtained by step S2 is added, is uniformly mixed, add another
The sodium sulphate of outer half, be uniformly mixed, dispense after the assay was approved to get.
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| CN112493258A (en) * | 2020-12-04 | 2021-03-16 | 四川超极制药有限公司 | Sodium dichloroisocyanurate powder and preparation method thereof |
| WO2021211411A1 (en) * | 2020-04-13 | 2021-10-21 | The University Of North Carolina At Chapel Hill | Disinfectant compositions and methods of making and using the same |
| JP2022007914A (en) * | 2020-05-27 | 2022-01-13 | 和日庵株式会社 | Hypochlorous water, composition for preparing hypochlorous water, and test paper for determining hypochlorous water |
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| CN101897335A (en) * | 2009-05-26 | 2010-12-01 | 潘运平 | Sodium dichloroisocyanurate powder |
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| CN1045332A (en) * | 1989-03-10 | 1990-09-19 | 李久春 | Disinfectant for animals and production technology |
| CN101049107A (en) * | 2006-07-11 | 2007-10-10 | 成都润兴消毒药业有限公司 | Sterilization powder, and preparation method. |
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| WO2021211411A1 (en) * | 2020-04-13 | 2021-10-21 | The University Of North Carolina At Chapel Hill | Disinfectant compositions and methods of making and using the same |
| JP2022007914A (en) * | 2020-05-27 | 2022-01-13 | 和日庵株式会社 | Hypochlorous water, composition for preparing hypochlorous water, and test paper for determining hypochlorous water |
| CN112493258A (en) * | 2020-12-04 | 2021-03-16 | 四川超极制药有限公司 | Sodium dichloroisocyanurate powder and preparation method thereof |
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