CN108618988A - A kind of Pimple removing scream and preparation method thereof containing alkannin - Google Patents
A kind of Pimple removing scream and preparation method thereof containing alkannin Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of Pimple removing scream and preparation method thereof containing alkannin.Pimple removing scream, in parts by weight, including 13 parts of alkannin, 0.1 0.3 parts of citric acid, 0.2 0.5 parts of antioxidant, 14.8 26.9 parts of auxiliary agent, 70 85 parts of solvent；The antioxidant is selected from one or more of vitamin C, honey, beeswax.The invention also discloses preparation methods.Main active alkannin of the present invention is natural plant extracts, does not add essence, pigment and the preservative of traditional chemical synthesis class, green and healthy.The Pimple removing scream of preparation can effectively facilitate skin metabolism, and activating skin cells protect skin not corroded by bacterium, hence it is evident that small pox is promoted to improve.
Description
Technical field
The present invention relates to daily cosmetics field more particularly to a kind of Pimple removing screams and preparation method thereof containing alkannin.
Background technology
Whelk is also known as acne, is a kind of chronic inflammatory skin of pilosebaceous unit.Sebaceous glands is opened on more
Follicular orifice, once follicular orifice blocks, mistake in the stimulation for the excess fat acid that the metabolism of excessive sebum generates and enclosed environment
The effect for spending the propionibacterium acnes of proliferation makes skin generate inflammatory reaction.
Currently, the product for the treatment of whelk contains the additives such as preservative mostly on the market, there is certain thorn to skin
Swash property, is used for a long time and easily forms scar or pigmentation, it is serious or even skin allergy can be caused, and since pathogen easily produces
Raw drug resistance, anti-acne effect are not satisfactory.
Alkannin is naphthoquinone compound, as Asian puccoon main pharmacodynamics ingredient, has antibacterial anti-inflammatory, detumescence convergence, anti-acne
It repairs, promote the bioactivity such as wound healing, can speed up the metabolism of acne print and scar, there is significant anti-acne, anti-acne
The effect of print and anti-inflammatory.For grease, the transmission of the electronics and proton of alkannin naphthoquinone compound can terminate grease
Free chain reaction, to play powerful antioxidation.Meanwhile alkannin can effectively inhibit by force leukotrienes
B4 (LTB4) and 5- hydroxyeicosatetraenoic acids (5-HETE) biosynthesis, to play anti-inflammatory effect.
In the prior art, the patent of entitled " Pimple removing scream " of Patent No. ZL200710035784.1, including Chinese medicine group
Side and matrix formulations include at least smilax, coix seed, pueraria lobata, Radix Astragali, chrysanthemum, Radix Ophiopogonis etc. in Chinese prescription used, in existing
Medicine complicated component, and the problems such as be not necessarily suitble to majority of populations, do not have experimental data definitely and prove prepared by face cream anti-acne
Effect.
Invention content
Goal of the invention：For problems of the prior art, the present invention provide a kind of Pimple removing scream containing alkannin and
Preparation method, prepared Pimple removing scream can effectively antibacterial, anti-inflammatory, anti-oxidant, nonirritant, anti-acne effect is apparent, makes
With conveniently, target user is extensive.
Technical solution：
Pimple removing scream of the present invention containing alkannin, in parts by weight, including：1-3 parts of alkannin, citric acid 0.1-
0.3 part, 0.2-0.5 parts of antioxidant, 14.8-26.9 parts of auxiliary agent, 70-85 parts of solvent；The antioxidant is selected from vitamin
C, one or more of honey, beeswax.
Wherein, the auxiliary agent be selected from gamma-cyclodextrin, moisturizer, saualane, 1,2- hexylene glycols, emulsifier, cholesterine,
One or more of thickener and vaseline.
Further, the Pimple removing scream of the present invention containing alkannin, in parts by weight, including：1-3 parts of alkannin,
4-8 parts of gamma-cyclodextrin, 5-8 parts of moisturizer, 0.1-0.3 parts of saualane, 1-3 parts of 1,2- hexylene glycols, 0.1-0.5 parts of emulsifier, courage
0.5-0.8 parts of sterol, 0.1-0.3 parts of thickener, 0.2-0.5 parts of antioxidant, 0.1-0.3 parts of citric acid, 4-6 parts of vaseline,
70-85 parts of solvent.
Alkannin：With anti-inflammatory, antibacterial action, be used locally for treatment burn and wound healing etc., have significant anti-acne,
The purity of anti-acne print, the bioactivity for promoting wound healing, the alkannin is 99.959%.
Moisturizer：With moisture-keeping efficacy；The moisturizer is selected from one or more of glycerine, propylene glycol, sorbierite.
Saualane：Saualane is that rare chemical stability is high, and the splendid animal fat of use feeling has preferably skin
Compatibility will not cause allergy and stimulation, and other active components in formula can be accelerated to be permeated into skin；With lower pole
Property and medium spreadability, and pure, colourless, free from extraneous odour；It may also suppress the growth of mould.Skin effect：1) reinforce maintenance table
Skin is effectively formed natural protective film, helps the balance between skin and sebum；2) peroxidating for inhibiting skin lipid, can effectively ooze
Skin is penetrated, and promotes the proliferation of skin base cell, to delay skin aging, improving and eliminating chloasma has apparent life
Manage effect；3) so that skin pore is opened, promote blood microcirculation, promote the metabolism of cell, damaged cell is repaired in help.
1,2- hexylene glycols：As solvent, fragrance, medical disinfectant.
Emulsifier：Surface reactive material has hydrophilic group and lipophilic group in molecule simultaneously, it is gathered on oil/water interface,
Interfacial tension can be reduced and reduction forms the required energy of emulsion, to improve the energy of emulsion；The emulsification
Agent is selected from one or more of PEG-100 stearates, PEG-60 stearates.
Cholesterine：It can safeguard the normal function of skin, it can also be used as stabilizer, emollients and water-retaining agent, skin
Drying can also play lubrication and moisturizing with cholesterol.
Thickener：Thickening power；The thickener is selected from one or more of carbomer, AVC；Carbomer is selected from card
One or more of wave 940, card wave 941, card wave U10, card wave U20, preferably card wave 941；
Antioxidant：The honey of antioxidation, preferably stability and good in oxidation resistance.
Citric acid：Belong to one kind of tartaric acid, main function is to speed up cutin update, and the update of cutin contributes in skin
The receipts of the peeling of melanin, pore are thin, the dissolving etc. of blackhead.
Vaseline：Dry skin and the various skin problems caused by drying can be alleviated with moisturizing, maintenance skin.
Gamma-cyclodextrin：Improve the stability of alkannin.
The solvent is water.
Above-mentioned formula system can guarantee the stable molding and anti-acne performance of face cream.
It is further preferred that the Pimple removing scream of the present invention containing alkannin, in parts by weight, including：Alkannin
1.5-2.5 parts, 4.5-5.5 parts of gamma-cyclodextrin, 5.5-6.5 parts of glycerine, 0.15-0.25 parts of saualane, 1,2- hexylene glycols 1.5-
2.5 parts, 0.15-0.25 parts of PEG-100 stearates, 0.55-0.65 parts of cholesterine, 0.15-0.25 parts of carbomer, honey
0.35-0.45 parts, 0.15-0.25 parts of citric acid, 4.5-5.5 parts of vaseline, 75-80 parts of water.
It is furthermore preferred that the Pimple removing scream of the present invention containing alkannin, in parts by weight, including：2 parts of alkannin, γ-
5 parts of cyclodextrin, 6 parts of glycerine, 0.2 part of saualane, 2 parts of 1,2- hexylene glycols, 0.2 part of PEG-100 stearates, 0.6 part of cholesterine,
0.2 part of carbomer, 0.4 part of honey, 0.2 part of citric acid, 5 parts of vaseline, 78.2 parts of water.
The present invention also provides the preparation methods of the Pimple removing scream containing alkannin, including：
(1) solvent, moisturizer, vaseline, the thickener of formula ratio, Hybrid Heating dissolving are weighed；
(2) 1,2- hexylene glycols, saualane, emulsifier, cholesterine, citric acid, fire-bar are added into the system of step (1)
It stirring and dissolving and is emulsified under part；
(3) after emulsifying completely, 45 DEG C -55 DEG C are cooled to, alkannin and antioxidant is added, stirring is allowed to dissolving fully,
Obtain Pimple removing scream.
In step (1), the temperature of heating for dissolving is 60 DEG C -70 DEG C；In step (2), the temperature of heating for dissolving is 60 DEG C -70
℃。
In the step (2), (3), agitating device is magnetite blender, and rotating speed is advisable in 300~500r/min or so.
In the step (3), gamma-cyclodextrin, alkannin and antioxidant is added when being cooled to 50 DEG C, it is possible to prevente effectively from
Under the high temperature conditions, alkannin is decomposed is aoxidized with antioxidant, to ensure the anti-acne effect of face cream
Advantageous effect：
For the present invention using alkannin as main functional component, purity is up to 99.9%, has significant anti-acne, anti-acne print and disappears
Scorching effect is aided with the antioxidation for accelerating cutin update and antioxidant such as honey of citric acid, can be assisted with synergy purple
The effect of careless element, accelerates the recovery of anti-acne and acne print；Prepared Pimple removing scream can effectively antibacterial, anti-inflammatory, anti-oxidant, it is stingless
Swash property, anti-acne effect is apparent, easy to use, and target user is extensive.
Main active alkannin of the present invention is natural plant extracts, does not add the essence of traditional chemical synthesis class
(such as aloe flavour, flavoring rose essence etc.), pigment (such as carmine, sunset is red ... etc.) and preservative (such as the different thiophene of methyl
Oxazoline ketone, parabens, formaldehyde and formaldehyde donor class ... etc.), it is green and healthy.The Pimple removing scream of preparation can effectively facilitate
Skin metabolism, activating skin cells protect skin not corroded by bacterium, hence it is evident that small pox is promoted to improve.
Specific implementation mode
With reference to specific embodiment, the present invention is furture elucidated.
Embodiment 1：
A kind of Pimple removing scream containing alkannin includes preparing raw material as follows by weight：1 part of alkannin, gamma-cyclodextrin
4 parts, 7 parts of glycerine, 0.1 part of saualane, 2 parts of 1,2- hexylene glycols, 0.3 part of PEG-100 stearates, 0.6 part of cholesterine, carbomer
0.3 part, 0.3 part of honey, 0.1 part of citric acid, 4 parts of vaseline, 80.3 parts of deionized water.
Wherein, the alkannin purity is 99.959%, and the carbomer is card wave 941.
The preparation method of the above-mentioned Pimple removing scream containing alkannin, includes the following steps：
(1) 80.3 parts of deionized waters, 7 parts of glycerine, 4 parts of vaseline, 0.3 part of carbomer are weighed, after mixing at 65 DEG C water
It is abundant that bath is heated to dissolving；
(2) it is hard that 2 parts of 1,2- hexylene glycols, 0.1 part of saualane, 0.3 part of PEG-100 are separately added into the system of step (1)
Resin acid ester, 0.6 part of cholesterine, 0.1 part of citric acid are allowed to dissolve and be emulsified under 65 DEG C of condition of water bath heating using agitating device；
(3) after emulsification completely, water-bath is cooled to 50 DEG C or so, and 4 parts of gamma-cyclodextrins, 1 part of alkannin and 0.3 part of bee is added
Honey is allowed to dissolving fully to get Pimple removing scream using agitating device；In step (2), (3), agitating device is magnetite blender,
Rotating speed is advisable in 300~500r/min or so.
Embodiment 2：
A kind of Pimple removing scream containing alkannin includes preparing raw material as follows by weight：2 parts of alkannin, gamma-cyclodextrin
5 parts, 6 parts of glycerine, 0.2 part of saualane, 2 parts of 1,2- hexylene glycols, 0.2 part of PEG-100 stearates, 0.6 part of cholesterine, carbomer
0.2 part, 0.4 part of honey, 0.2 part of citric acid, 5 parts of vaseline, 78.2 parts of deionized water.
Wherein, the alkannin purity is 99.959%, and the carbomer is card wave 941.
The preparation method of the above-mentioned Pimple removing scream containing alkannin, includes the following steps：
(1) 78.2 parts of water, 6 parts of glycerine, 5 parts of vaseline, 0.2 part of carbomer are weighed, after mixing at 65 DEG C heating water bath
It is abundant to dissolving；
(2) it is hard that 2 parts of 1,2- hexylene glycols, 0.2 part of saualane, 0.2 part of PEG-100 are separately added into the system of step (1)
Resin acid ester, 0.6 part of cholesterine, 0.2 part of citric acid are allowed to dissolve and be emulsified under 65 DEG C of condition of water bath heating using agitating device；
(3) after emulsification completely, water-bath is cooled to 50 DEG C or so, and 5 parts of gamma-cyclodextrins, 2 parts of alkannins and 0.4 part of bee is added
Honey is allowed to dissolving fully to get Pimple removing scream using agitating device；In step (2), (3), agitating device is magnetite blender,
Rotating speed is advisable in 300~500r/min or so.
Embodiment 3：
A kind of Pimple removing scream containing alkannin includes preparing raw material as follows by weight：3 parts of alkannin, gamma-cyclodextrin
6 parts, 7 parts of glycerine, 0.2 part of saualane, 3 parts of 1,2- hexylene glycols, 0.5 part of PEG-100 stearates, 0.7 part of cholesterine, carbomer
0.2 part, 0.4 part of honey, 0.2 part of citric acid, 4 parts of vaseline, 74.8 parts of deionized water.
Wherein, the alkannin purity is 99.959%, and the carbomer is card wave 941.
A kind of preparation method of above-mentioned Pimple removing scream containing alkannin, includes the following steps：
(1) 74.8 parts of water, 7 parts of glycerine, 4 parts of vaseline, 0.2 part of carbomer are weighed, after mixing at 65 DEG C heating water bath
It is abundant to dissolving；
(2) it is hard that 3 parts of 1,2- hexylene glycols, 0.2 part of saualane, 0.5 part of PEG-100 are separately added into the system of step (1)
Resin acid ester, 0.7 part of cholesterine, 0.2 part of citric acid are allowed to dissolve and be emulsified under 65 DEG C of condition of water bath heating using agitating device；
(3) after emulsification completely, water-bath is cooled to 50 DEG C or so, and 6 parts of gamma-cyclodextrins, 3 parts of alkannins and 0.4 part of bee is added
Honey is allowed to dissolving fully to get Pimple removing scream using agitating device；In step (2), (3), agitating device is magnetite blender,
Rotating speed is advisable in 300~500r/min or so.
Embodiment 4：
A kind of Pimple removing scream containing alkannin includes preparing raw material as follows by weight：3 parts of alkannin, gamma-cyclodextrin
6 parts, 7 parts of glycerine, 0.2 part of saualane, 3 parts of 1,2- hexylene glycols, 0.5 part of PEG-100 stearates, 0.7 part of cholesterine, carbomer
0.2 part, 0.2 part of citric acid, 4 parts of vaseline, 74.8 parts of deionized water.
Wherein, the alkannin purity is 99.959%, and the carbomer is card wave 941.
A kind of preparation method of above-mentioned Pimple removing scream containing alkannin, includes the following steps：
(1) 74.8 parts of water, 7 parts of glycerine, 4 parts of vaseline, 0.2 part of carbomer are weighed, after mixing at 65 DEG C heating water bath
It is abundant to dissolving；
(2) it is hard that 3 parts of 1,2- hexylene glycols, 0.2 part of saualane, 0.5 part of PEG-100 are separately added into the system of step (1)
Resin acid ester, 0.7 part of cholesterine, 0.2 part of citric acid are allowed to dissolve and be emulsified under 65 DEG C of condition of water bath heating using agitating device；
(3) after emulsification completely, water-bath is cooled to 50 DEG C or so, 6 parts of gamma-cyclodextrins, 3 parts of alkannins is added, using stirring
Device is allowed to dissolving fully to get Pimple removing scream；In step (2), (3), agitating device is magnetite blender, rotating speed 300~
500r/min or so is advisable.
Embodiment 5：
A kind of Pimple removing scream containing alkannin includes preparing raw material as follows by weight：3 parts of alkannin, gamma-cyclodextrin
6 parts, 7 parts of glycerine, 0.2 part of saualane, 3 parts of 1,2- hexylene glycols, 0.5 part of PEG-100 stearates, 0.7 part of cholesterine, carbomer
0.2 part, 0.4 part of honey, 4 parts of vaseline, 74.8 parts of deionized water.
Wherein, the alkannin purity is 99.959%, and the carbomer is card wave 941.
A kind of preparation method of above-mentioned Pimple removing scream containing alkannin, includes the following steps：
(1) 74.8 parts of water, 7 parts of glycerine, 4 parts of vaseline, 0.2 part of carbomer are weighed, after mixing at 65 DEG C heating water bath
It is abundant to dissolving；
(2) it is hard that 3 parts of 1,2- hexylene glycols, 0.2 part of saualane, 0.5 part of PEG-100 are separately added into the system of step (1)
Resin acid ester, 0.7 part of cholesterine are allowed to dissolve and be emulsified under 65 DEG C of condition of water bath heating using agitating device；
(3) after emulsification completely, water-bath is cooled to 50 DEG C or so, and 6 parts of gamma-cyclodextrins, 3 parts of alkannins and 0.4 part of bee is added
Honey is allowed to dissolving fully to get Pimple removing scream using agitating device；In step (2), (3), agitating device is magnetite blender,
Rotating speed is advisable in 300~500r/min or so.
Embodiment 6
To show beneficial effects of the present invention, the clinical effectiveness of the present invention is now used to be reported as follows：
Application：Patient age is chosen in 18-35 Sui sufferer totally 80, wherein women 40, male 40.It is all
The face of patient etc. has different degrees of small pox or acne print, wherein more severe case 5.
Test sample：Trial product uses the anti-acne containing alkannin of three formulas and method production by the embodiment of the present invention
Face cream.
Application testing method：After all small poxs are checked by researcher, the Pimple removing scream containing alkannin is applied to
Affected part.Patient takes the Pimple removing scream containing alkannin home, daily using 2-3 times, using preceding cleaning affected part, during use
Avoid tobacco and wine and maror.It is paid a return visit after 1 month, observes small pox Cure.
Evaluation method and evaluation criterion：After the Pimple removing scream one month containing alkannin, whether observation small pox is cured or is subtracted
Gently.Cure is divided into level-one, two level, three-level and cures, and counts Cure rate.Wherein：
Level-one is cured：Small pox completely disappears, and skin restores normal；
Two level is cured：Also a small amount of small pox, skin are restored；
Three-level is cured：Small pox does not disappear substantially, and skin is without improvement.
Test result：Treatment investigation such as following table after one month.
| Group | Number | Level-one cures (people) | Two level cures (people) | Three-level cures (people) |
| Embodiment 1 | 20 | 14 | 6 | 0 |
| Embodiment 2 | 20 | 16 | 3 | 1 |
| Embodiment 3 | 20 | 15 | 4 | 1 |
| Embodiment 4 | 20 | 11 | 7 | 2 |
| Embodiment 5 | 20 | 12 | 6 | 2 |
Conclusion (of pressure testing)：From the point of view of above-mentioned statistical conditions, the level-one cure rate of embodiment 1,2,3 is all higher than 60%, and implements
The level-one cure rate highest of example 2 illustrates that the Pimple removing scream containing alkannin prepared by the present invention is bright for the curative effect of small pox
It is aobvious, and anti-acne effect is best in most preferably raw material dosage；The cure rate of embodiment 1,2,3 is obviously higher than embodiment 4,5, says
Bright honey and citric acid are a supporting role the anti-acne effect of alkannin.
It should be pointed out that the above specific implementation mode is only illustrative of the invention and is not intended to limit the scope of the invention,
After having read the present invention, those skilled in the art fall within appended by the application the modification of the various equivalent forms of the present invention and weigh
Profit requires limited range.
Claims (10)
1. a kind of Pimple removing scream containing alkannin, which is characterized in that in parts by weight, including：1-3 parts of alkannin, citric acid
0.1-0.3 parts, 0.2-0.5 parts of antioxidant, 14.8-26.9 parts of auxiliary agent, 70-85 parts of solvent；The antioxidant is selected from dimension
One or more of raw element C, honey, beeswax.
2. the Pimple removing scream according to claim 1 containing alkannin, which is characterized in that the auxiliary agent is selected from γ-ring paste
One or more of essence, moisturizer, saualane, 1,2- hexylene glycols, emulsifier, cholesterine, thickener and vaseline.
3. the Pimple removing scream according to claim 2 containing alkannin, which is characterized in that in parts by weight, including：Alkannin
1-3 parts, 4-8 parts of gamma-cyclodextrin, 5-8 parts of moisturizer, 0.1-0.3 parts of saualane, 1-3 parts of 1,2- hexylene glycols, emulsifier 0.1-
0.5 part, 0.5-0.8 parts of cholesterine, 0.1-0.3 parts of thickener, 0.2-0.5 parts of antioxidant, 0.1-0.3 parts of citric acid, all scholars
4-6 parts of woods, 70-85 parts of solvent.
4. the Pimple removing scream according to claim 2 or 3 containing alkannin, which is characterized in that the moisturizer is selected from sweet
One or more of oil, propylene glycol, sorbierite.
5. the Pimple removing scream according to claim 2 or 3 containing alkannin, which is characterized in that the emulsifier is selected from
One or more of PEG-100 stearates, PEG-60 stearates.
6. the Pimple removing scream according to claim 2 or 3 containing alkannin, which is characterized in that the thickener is selected from card
One or more of wave nurse, AVC.
7. according to Pimple removing scream of the claim 1-3 any one of them containing alkannin, which is characterized in that the solvent is
Water.
8. according to the preparation method of Pimple removing scream of the claim 3-7 any one of them containing alkannin, which is characterized in that packet
It includes：
(1) solvent, moisturizer, vaseline, the thickener of formula ratio, Hybrid Heating dissolving are weighed；
(2) 1,2- hexylene glycols, saualane, emulsifier, cholesterine, citric acid are added into the system of step (1), under heating condition
Stirring and dissolving simultaneously emulsifies；
(3) after emulsification completely, 45 DEG C -55 DEG C are cooled to, gamma-cyclodextrin, alkannin and antioxidant is added, stirring is allowed to dissolve
Fully, Pimple removing scream is obtained.
9. the preparation method of the Pimple removing scream according to claim 8 containing alkannin, which is characterized in that in step (1), add
The temperature of heat of solution is 60 DEG C -70 DEG C.
10. the preparation method of the Pimple removing scream according to claim 8 containing alkannin, which is characterized in that in step (2),
The temperature of heating for dissolving is 60 DEG C -70 DEG C.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568243A (en) * | 2019-01-31 | 2019-04-05 | 张鹭云 | A kind of waterless nano vitamin C face cream and preparation method thereof |
| CN111529448A (en) * | 2020-06-04 | 2020-08-14 | 广州欧盛化妆品有限公司 | Skin barrier repair cream and preparation method thereof |
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| CN113995693A (en) * | 2021-11-23 | 2022-02-01 | 湖北省麦诗特生物科技有限公司 | Essence composition with anti-inflammatory effect liposome and preparation method and application thereof |
| CN114099358A (en) * | 2021-11-23 | 2022-03-01 | 湖北省麦诗特生物科技有限公司 | Shikonin moisturizing cream composition with fastness and preparation method thereof |
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