CN108602848B - 1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂 - Google Patents

1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂 Download PDF

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Publication number
CN108602848B
CN108602848B CN201680076549.6A CN201680076549A CN108602848B CN 108602848 B CN108602848 B CN 108602848B CN 201680076549 A CN201680076549 A CN 201680076549A CN 108602848 B CN108602848 B CN 108602848B
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galectin
compound
group
formula
alkyl
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Chinese (zh)
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CN108602848A (zh
Inventor
F·塞特贝里
U·尼尔松
H·莱弗勒
A·彼得森
H·尚比
T·布里默特
R·约翰森
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Galecto Biotech AB
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Galecto Biotech AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201680076549.6A 2015-11-09 2016-11-08 1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂 Expired - Fee Related CN108602848B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15193657 2015-11-09
EP15193657.2 2015-11-09
EP16172358 2016-06-01
EP16172358.0 2016-06-01
PCT/EP2016/076918 WO2017080973A1 (en) 2015-11-09 2016-11-08 1,1 '-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins

Publications (2)

Publication Number Publication Date
CN108602848A CN108602848A (zh) 2018-09-28
CN108602848B true CN108602848B (zh) 2022-01-18

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CN201680076549.6A Expired - Fee Related CN108602848B (zh) 2015-11-09 2016-11-08 1，1’-硫烷二基-二-β-D-吡喃半乳糖苷作为半乳糖凝集素的抑制剂

Country Status (7)

Country Link
US (1) US10730902B2 (cg-RX-API-DMAC7.html)
EP (1) EP3374368B1 (cg-RX-API-DMAC7.html)
JP (1) JP6892859B2 (cg-RX-API-DMAC7.html)
CN (1) CN108602848B (cg-RX-API-DMAC7.html)
CA (1) CA3000924A1 (cg-RX-API-DMAC7.html)
ES (1) ES2921500T3 (cg-RX-API-DMAC7.html)
WO (1) WO2017080973A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109563119A (zh) * 2016-07-12 2019-04-02 格莱克特生物技术公司 半乳糖凝集素的α-D-半乳糖苷抑制剂
KR102626669B1 (ko) 2017-05-12 2024-01-17 갈랙틴 사이언시즈, 엘엘씨 질환의 예방 및 치료를 위한 화합물 및 이의 용도
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
US11267811B2 (en) 2017-09-27 2022-03-08 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
WO2019075045A1 (en) 2017-10-11 2019-04-18 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
EP3807290B1 (en) 2018-06-15 2022-03-30 Bristol-Myers Squibb Company Tetrahydropyran-based thiodisaccharide mimics as galectin-3 inhibitors
WO2020117883A1 (en) 2018-12-06 2020-06-11 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
JP7547345B2 (ja) 2018-12-27 2024-09-09 グリコミメティクス， インコーポレイテッド ガレクチン－３阻害性ｃ－グリコシド
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
WO2021081881A1 (zh) * 2019-10-31 2021-05-06 深圳先进技术研究院 一种基于tdg分子骨架的功能糖类分子及其制备方法
CN113521283A (zh) * 2020-04-14 2021-10-22 中国医学科学院药物研究所 Galectin-3作为靶标在寻找保护胰岛功能药物或者生物制剂中的应用
US12275720B2 (en) 2020-05-05 2025-04-15 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
WO2021231243A1 (en) 2020-05-11 2021-11-18 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
CN115768768A (zh) 2020-05-28 2023-03-07 百时美施贵宝公司 半乳凝素-3抑制剂
WO2022171561A1 (en) * 2021-02-10 2022-08-18 Galecto Biotech Ab Novel galactoside inhibitor of galectins

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057284A1 (en) * 2001-01-22 2002-07-25 Ulf Nilsson New inhibitors against galectins
WO2005113569A1 (en) * 2004-05-21 2005-12-01 Forskapatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
CN102066393A (zh) * 2008-05-16 2011-05-18 佛斯卡专利公司 半乳糖苷抑制剂的新颖的合成
CN102439021A (zh) * 2009-04-28 2012-05-02 南方佛斯卡专利公司 半乳凝素的新型半乳糖苷抑制剂
CN104755088A (zh) * 2012-10-31 2015-07-01 格莱克特生物技术公司 半乳凝集素-3的半乳糖苷抑制剂及其用于治疗肺纤维化的应用
CN104955471A (zh) * 2012-11-15 2015-09-30 塔夫斯大学 使用半乳糖凝集素蛋白抑制剂用于治疗、调节或预防受试者的眼部血管生成或者纤维化的方法、组合物以及试剂盒
WO2016005311A1 (en) * 2014-07-09 2016-01-14 Galecto Biotech Ab Novel hybrid galactoside inhibitor of galectins
WO2016113335A1 (en) * 2015-01-16 2016-07-21 Galecto Biotech Ab Novel galactoside inhibitor of galectins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401300D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel Galactoside Inhibitors of Galectins
KR102231732B1 (ko) 2012-10-10 2021-03-23 갈렉틴 테라퓨틱스, 인크. 당뇨병성 신장병증 및 관련 질환의 치료를 위한 갈락토스 갈래의 탄수화물 화합물
CA2970062C (en) 2015-01-30 2023-02-28 Galecto Biotech Ab Alpha-d-galactoside inhibitors of galectins

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057284A1 (en) * 2001-01-22 2002-07-25 Ulf Nilsson New inhibitors against galectins
WO2005113569A1 (en) * 2004-05-21 2005-12-01 Forskapatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
CN102066393A (zh) * 2008-05-16 2011-05-18 佛斯卡专利公司 半乳糖苷抑制剂的新颖的合成
CN102439021A (zh) * 2009-04-28 2012-05-02 南方佛斯卡专利公司 半乳凝素的新型半乳糖苷抑制剂
CN104755088A (zh) * 2012-10-31 2015-07-01 格莱克特生物技术公司 半乳凝集素-3的半乳糖苷抑制剂及其用于治疗肺纤维化的应用
CN104955471A (zh) * 2012-11-15 2015-09-30 塔夫斯大学 使用半乳糖凝集素蛋白抑制剂用于治疗、调节或预防受试者的眼部血管生成或者纤维化的方法、组合物以及试剂盒
WO2016005311A1 (en) * 2014-07-09 2016-01-14 Galecto Biotech Ab Novel hybrid galactoside inhibitor of galectins
WO2016113335A1 (en) * 2015-01-16 2016-07-21 Galecto Biotech Ab Novel galactoside inhibitor of galectins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors;Bader A. Salameh, et al.;《Bioorganic & Medicinal Chemistry》;20100520;第18卷;第5367-5378页 *

Also Published As

Publication number Publication date
EP3374368B1 (en) 2022-06-01
JP2018534301A (ja) 2018-11-22
EP3374368A1 (en) 2018-09-19
CN108602848A (zh) 2018-09-28
US20180327440A1 (en) 2018-11-15
CA3000924A1 (en) 2017-05-18
WO2017080973A1 (en) 2017-05-18
US10730902B2 (en) 2020-08-04
ES2921500T3 (es) 2022-08-26
JP6892859B2 (ja) 2021-06-23

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