CN108601554B - 用于治疗癌症和转移的低强度聚焦超声 - Google Patents

用于治疗癌症和转移的低强度聚焦超声 Download PDF

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CN108601554B
CN108601554B CN201680045882.0A CN201680045882A CN108601554B CN 108601554 B CN108601554 B CN 108601554B CN 201680045882 A CN201680045882 A CN 201680045882A CN 108601554 B CN108601554 B CN 108601554B
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tumor
ultrasound
transducers
lofu
treatment
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CN108601554A (zh
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C·古哈
斯蒂芬·巴里
费尔南多·马西安
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Montefiore Medical Center
Albert Einstein College of Medicine
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Montefiore Medical Center
Albert Einstein College of Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
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    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
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    • A61K31/33—Heterocyclic compounds
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    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
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    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
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    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
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    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
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    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source
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    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A—HUMAN NECESSITIES
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    • A61N2007/0043—Ultrasound therapy intra-cavitary
    • A—HUMAN NECESSITIES
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/0065—Concave transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
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    • A61N2007/0091—Beam steering with moving parts, e.g. transducers, lenses, reflectors
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    • A61N2007/0095—Beam steering by modifying an excitation signal

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Human Computer Interaction (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN201680045882.0A 2015-06-03 2016-06-02 用于治疗癌症和转移的低强度聚焦超声 Active CN108601554B (zh)

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US201562170378P 2015-06-03 2015-06-03
US62/170,378 2015-06-03
US201562204312P 2015-08-12 2015-08-12
US62/204,312 2015-08-12
PCT/US2016/035440 WO2016196741A2 (en) 2015-06-03 2016-06-02 Low intensity focused ultrasound for treating cancer and metastasis

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144931A1 (en) 2015-03-09 2016-09-15 The Research Foundation For The State University Of New York Systems and methods for promoting cellular activities for tissue maintenance, repair, and regeneration
US10974077B2 (en) * 2015-06-03 2021-04-13 Montefiore Medical Center Low intensity focused ultrasound for treating cancer and metastasis
WO2018071908A1 (en) 2016-10-16 2018-04-19 Vibrato Medical, Inc. Extracorporeal therapeutic ultrasound for promoting angiogenesis
WO2019094802A1 (en) 2017-11-09 2019-05-16 Montefiore Medical Center Low energy immune priming for treating cancer and metastasis
JP7408563B2 (ja) * 2017-12-22 2024-01-05 フリーダム ウェイブス エッセ．エッレ．エッレ． 薬物の癌細胞へのソノポレーションを誘導するためのシステム及びその方法
US11260249B2 (en) * 2018-07-19 2022-03-01 Sonablate Corp. System, apparatus and method for high intensity focused ultrasound and tissue healing activation
JP2020110282A (ja) * 2019-01-10 2020-07-27 治 三宅 生体用の超音波照射治療装置
JP7474773B2 (ja) 2019-02-13 2024-04-25 アルフェウス メディカル，インク． 非侵襲的音響化学療法
WO2020165383A1 (fr) * 2019-02-15 2020-08-20 Boysset Max Pièce d'habillement et méthode de contrôle de cellules utilisant une telle pièce d'habillement
CN110507917A (zh) * 2019-07-30 2019-11-29 哈尔滨医科大学 一种超高场磁共振引导的低强度聚焦超声爆破系统
CN114761076A (zh) * 2019-08-27 2022-07-15 蒙特非奥里医疗中心 放射疗法的消融后调节
US20210169979A1 (en) * 2019-12-05 2021-06-10 The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges System and method for sonosensitized cancer immunotherapy with nanoparticles
CN116348146A (zh) * 2020-08-06 2023-06-27 蒙特非奥里医疗中心 作为放射疗法的辅助的树突细胞活化疗法
CA3185803A1 (en) 2020-08-07 2022-02-10 Vijay Agarwal Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
TWI843989B (zh) 2021-02-19 2024-06-01 美商美威高能離子醫療系統公司 用於粒子治療系統之支架
US12364880B2 (en) * 2021-03-15 2025-07-22 Guided Therapy Systems, Llc Method for mid-intensity, non-ablative acoustic treatment of injured tissue
WO2023060199A1 (en) * 2021-10-06 2023-04-13 The Trustees Of Columbia University In The City Of New York Method and integrated system for selective removal of defective cells and edematous fluids from the lung
US20250041577A1 (en) * 2021-12-10 2025-02-06 Insightec, Ltd. Short-pulse sonodynamic treatment apparatus
US20230293913A1 (en) * 2022-03-17 2023-09-21 Open Water Internet Inc. Harmonic excitation therapy and anti-tumor agent
WO2024042447A1 (en) 2022-08-22 2024-02-29 Laserleap Technologies, S.A. Devices and methods for priming solid tumors with pressure pulses to enhance anticancer therapies
WO2024246914A1 (en) * 2023-06-01 2024-12-05 B.G. Negev Technologies And Applications Ltd. Therapeutic ultrasound methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011128693A1 (en) * 2010-04-16 2011-10-20 Cancercure Technology As Systems for inducing hyperthermia
WO2014021489A1 (ko) * 2012-07-30 2014-02-06 노슨 주식회사 기울기 정보를 가지는 초음파 프로브, 그를 이용한 초음파 진단 및 치료 장치

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068961A3 (fr) 1981-06-26 1983-02-02 Thomson-Csf Dispositif d'échauffement localisé de tissus biologiques
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
AU1579901A (en) 1999-11-01 2001-05-14 University Of Cincinnati, The Transcranial ultrasound thrombolysis system and method of treating a stroke
US6725095B2 (en) 2000-04-13 2004-04-20 Celsion Corporation Thermotherapy method for treatment and prevention of cancer in male and female patients and cosmetic ablation of tissue
US6821274B2 (en) * 2001-03-07 2004-11-23 Gendel Ltd. Ultrasound therapy for selective cell ablation
US20100087728A1 (en) 2000-11-28 2010-04-08 Physiosonics, Inc. Acoustic palpation using non-invasive ultrasound techniques to identify and localize tissue eliciting biological responses
US20040034304A1 (en) 2001-12-21 2004-02-19 Chikayoshi Sumi Displacement measurement method and apparatus, strain measurement method and apparatus elasticity and visco-elasticity constants measurement apparatus, and the elasticity and visco-elasticity constants measurement apparatus-based treatment apparatus
ES2315493T3 (es) * 2002-05-23 2009-04-01 Gendel Limited Dispositivo de ablacion.
US7396336B2 (en) 2003-10-30 2008-07-08 Sherwood Services Ag Switched resonant ultrasonic power amplifier system
US7896821B1 (en) * 2003-11-14 2011-03-01 Perfusion Technology, LLC Low intensity directed ultrasound (LODUS) mediated blood brain barrier disruption
WO2005065371A2 (en) 2003-12-30 2005-07-21 Liposonix, Inc. Systems and methods for the destruction of adipose tissue
AU2005213235A1 (en) 2004-02-12 2005-08-25 Neurosonix Ltd Acoustic control of emboli in vivo
KR100537343B1 (ko) * 2004-10-01 2005-12-19 주식회사 듀플로젠 관절염 치료용 초음파 장치
WO2006050058A2 (en) 2004-10-28 2006-05-11 The General Hospital Corporation Methods of detection and therapy of inflamed tissues using immune modulation
CN1814323B (zh) * 2005-01-31 2010-05-12 重庆海扶(Hifu)技术有限公司 一种聚焦超声波治疗系统
US7194063B2 (en) 2005-02-10 2007-03-20 Brookhaven Science Associates, Llc Methods for implementing microbeam radiation therapy
WO2006113794A2 (en) 2005-04-20 2006-10-26 Richard Blankenbecler Treatment to reduce damage from radiation therapy
EP1904179A2 (en) * 2005-06-07 2008-04-02 Koninklijke Philips Electronics N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids
JP4369907B2 (ja) * 2005-07-01 2009-11-25 株式会社日立製作所 音響化学治療装置
KR20080039925A (ko) 2005-07-22 2008-05-07 토모테라피 인코포레이티드 생물학적 모델에 기초하여 방사선 요법 치료 계획을적합화시키는 방법 및 시스템
WO2007044469A2 (en) * 2005-10-05 2007-04-19 Perfusion Technology, Llp A method and apparatus to direct radiation treatment to a specific region of the brain
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
WO2010029556A1 (en) * 2008-09-12 2010-03-18 Slender Medical, Ltd. A device for ultrasound treatment and monitoring tissue treatment
JP5032094B2 (ja) * 2006-11-06 2012-09-26 テルモ株式会社 超音波診断装置および制御プログラム
US20080317204A1 (en) 2007-03-16 2008-12-25 Cyberheart, Inc. Radiation treatment planning and delivery for moving targets in the heart
CN101820949B (zh) 2007-03-30 2017-05-24 皇家飞利浦电子股份有限公司 用于引导放疗和其他过程的mri引导的hifu标记法
US20100092424A1 (en) 2007-11-21 2010-04-15 Sanghvi Narendra T Method of diagnosis and treatment of tumors using high intensity focused ultrasound
WO2009070677A1 (en) 2007-11-28 2009-06-04 Reliant Technologies, Inc. Nonablative and ablative tissue treatment method and device
US8466605B2 (en) * 2008-03-13 2013-06-18 Ultrashape Ltd. Patterned ultrasonic transducers
US20100286673A1 (en) 2008-03-17 2010-11-11 Palomar Medical Technologies, Inc. Method and apparatus for treatment of tissue
WO2010009141A1 (en) 2008-07-14 2010-01-21 Arizona Board Of Regents For And On Behalf Of Arizona State University Methods and devices for modulating cellular activity using ultrasound
US8962290B2 (en) 2008-08-26 2015-02-24 Intelligentnano Inc. Enhanced animal cell growth using ultrasound
CN101642607B (zh) * 2009-09-01 2012-11-28 西安交通大学 基于阵列换能器的低强度聚焦超声药物控释与监控装置
CN101690677B (zh) * 2009-10-13 2011-09-21 西安交通大学 聚焦超声治疗组合阵元相控阵及多焦点剪切波成像系统
US20130144192A1 (en) * 2011-07-17 2013-06-06 Neurotrek, Inc. Ultrasound neuromodulation treatment of anxiety (including panic attacks) and obsessive-compulsive disorder
BR112012029726A2 (pt) * 2010-05-27 2017-09-26 Koninl Philips Electronics Nv método para a operação de um transdutor ultrassônico, transdutor ultrassônico para a geração seletiva de ondas ultrassônicas e calor, e sistema para análise de amostra
US8777854B2 (en) * 2011-09-06 2014-07-15 General Electric Company Method and system for ultrasound based automated detection, quantification and tracking of pathologies
US20140058293A1 (en) * 2012-05-23 2014-02-27 Sunnybrook Research Institute Multi-Frequency Ultrasound Device and Method of Operation
EP2864792A1 (en) 2012-06-26 2015-04-29 Biodesix, Inc. Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
CA2878491A1 (en) * 2012-07-08 2014-01-16 Sunnybrook Health Sciences Centre System and method for using ultrasound-stimulated microbubble exposures to induce ceramide accumulation in endothelial and tumor cells
CN102831716A (zh) * 2012-08-27 2012-12-19 曲宝源 预付费球形膨胀腔低压损立柱式超声波热量表
US9061133B2 (en) * 2012-12-27 2015-06-23 Brainsonix Corporation Focused ultrasonic transducer navigation system
AU2014207272A1 (en) * 2013-01-18 2015-07-30 Neal D. Andruska Estrogen receptor inhibitors
CN203112640U (zh) * 2013-02-05 2013-08-07 韩先锋 旋流分区式船舶压载水处理装置
US10960233B2 (en) 2013-03-06 2021-03-30 B.G. Negev Technologies And Applications Ltd. Low intensity ultrasound therapy
WO2014145007A1 (en) 2013-03-15 2014-09-18 Eagleyemed Ultrasound probe
CN103230648B (zh) * 2013-04-24 2016-09-14 重庆医科大学 低强度聚焦超声分子显像与治疗系统
WO2015067786A1 (en) * 2013-11-08 2015-05-14 Koninklijke Philips N.V. Medical apparatus for radiotherapy and ultrasound heating
CN110575244A (zh) 2013-11-19 2019-12-17 伊西康公司 用于治疗支气管疾病的胸腔镜方法
TW201521671A (zh) * 2013-12-11 2015-06-16 Univ Nat Taiwan 超音波醫療裝置
US11547300B2 (en) 2014-01-31 2023-01-10 The General Hospital Corporation Methods of treating and imaging tumor micrometastases using photoactive immunoconjugates
KR102465947B1 (ko) 2014-04-18 2022-11-10 얼테라, 인크 밴드 트랜스듀서 초음파 치료
EP3247280B1 (en) 2015-01-15 2023-07-12 Herring, Rodney Diffuse acoustic confocal imager
CN104874114A (zh) 2015-06-01 2015-09-02 天津大学 一种利用低强度超声促进放射治疗效应的系统
US10974077B2 (en) 2015-06-03 2021-04-13 Montefiore Medical Center Low intensity focused ultrasound for treating cancer and metastasis
WO2017079431A1 (en) 2015-11-05 2017-05-11 The General Hospital Corporation Methods for treating cancer by enhancing intratumoral immune response
KR101875111B1 (ko) 2016-04-29 2018-07-09 한국수력원자력 주식회사 저선량 방사선을 이용한 암화유전자 Ras-유도 악성 암화 억제
US20180154183A1 (en) 2016-06-22 2018-06-07 Velayudhan Sahadevan Normal Tissue Toxicity Reducing Microbeam-Broadbeam Radiotherapy, Skin's Radio-Response Immunotherapy and Mutated Molecular Apheresis Combined Cancer Treatments
US11684802B2 (en) 2016-12-31 2023-06-27 Radiation Barrier Llc Reducing damage from radiation therapy and increasing cancer kill rates by interweaving of low and high dose sessions
MX2019007729A (es) 2016-12-31 2019-08-29 Radiation Barrier Llc Reducción del daño de la quimioterapia y aumento de las tasas de destrucción de cáncer usando radiación entremezclada de baja dosis.
WO2019094802A1 (en) 2017-11-09 2019-05-16 Montefiore Medical Center Low energy immune priming for treating cancer and metastasis
WO2020123388A1 (en) 2018-12-11 2020-06-18 Board Of Regents, The University Of Texas System Radiotherapies and uses thereof
CN114761076A (zh) 2019-08-27 2022-07-15 蒙特非奥里医疗中心 放射疗法的消融后调节

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011128693A1 (en) * 2010-04-16 2011-10-20 Cancercure Technology As Systems for inducing hyperthermia
WO2014021489A1 (ko) * 2012-07-30 2014-02-06 노슨 주식회사 기울기 정보를 가지는 초음파 프로브, 그를 이용한 초음파 진단 및 치료 장치

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
low intensity focused ultrasound(LOFU) modulates unfold protein response and sensitizes prostate cancer to 17 AAG;Subhrajit Saha 等;《Oncoscience》;20150131;第1卷(第6期);第434-445页 *

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