CN108578633A - A kind of Wei-chang-an Capsule and preparation method thereof - Google Patents

A kind of Wei-chang-an Capsule and preparation method thereof Download PDF

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CN108578633A
CN108578633A CN201810849006.4A CN201810849006A CN108578633A CN 108578633 A CN108578633 A CN 108578633A CN 201810849006 A CN201810849006 A CN 201810849006A CN 108578633 A CN108578633 A CN 108578633A
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capsule
parts
chang
wei
preparation
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赵婉汝
赵文贤
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Shaanxi Hui Fu Pharmaceutical Co Ltd
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Shaanxi Hui Fu Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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Abstract

The invention discloses a kind of Wei-chang-an Capsules and preparation method thereof, belong to the field of Chinese medicines.The raw material group of capsule of the present invention becomes：Cuttlebone, fritillaria thunbergii, fructus amomi, the bletilla striata, corydalis tuber, Radix Paeoniae Alba, Radix Notoginseng, the tuber of pinellia, dandelion, dried orange peel, Radix Glycyrrhizae.The present invention provides a kind of Wei-chang-an Capsule preparation methods.The present invention is relieved pain with relieving haperacidity, the functions such as regulating qi-flowing for harmonizing stomach, it can be used for epigastric distension and distress, pain caused by treating gastric and duodenal ulcer simultaneously, the illnesss such as sour regurgitation, acid regurgitation, pure Chinese medicine formula, be conducive to patient's long-term use, while capsule preparations, stable quality, favorable reproducibility, safely, effectively, be easy to preserve and storage.

Description

A kind of Wei-chang-an Capsule and preparation method thereof
Technical field
The present invention relates to medical manufacture fields more particularly to a kind of Wei-chang-an Capsule and preparation method thereof.
Background technology
The taste of traditional Chinese medicine are not equal to spleen and stomach in modern medicine anatomical concepts meaning, the function packet of Chinese medicine taste The physiological function of anatomy taste is included, and in extensive range more than what anatomy taste were related to.The cause of disease of Chinese medicine the spleen-stomach diseases, pathology Though not as modern medicine study gastritis, peptic ulcer etiology and pathology it is specific, by its basic sides (attack because Element, defending factors, mental element and immune factor) include all, or even compared with covering face bigger, as generation-inhibition in five elements relationship and Pathological product cause a disease etc..According to the theory of the Chinese medicine theory of spleen and stomach, the function of taste does not have gastritis, peptic ulcer disease then normally Generation.
Clinical practice proves, by using the prescription of adjustment spleen and stomach function, there is treatment to make gastritis, peptic ulcer With.As long as using accurate proper, produce effects good, the effect of sometimes even over modern medicine.
With the development of society, people's rhythm of life is getting faster, and it is irregular on many people's living and diets, it is not careful in one's diet Health and raw and cold frying etc., cause it to fall a series of stomach trouble.
Wherein gastritis, peptic ulcer disease, relatively conventional two kinds of diseases in numerous stomach trouble under today's society.Gastritis point is acute Gastritis and chronic gastritis, clinically Symptoms be：Loss of appetite, weight loss is tired, abdominal distension, stomach-ache, hyperhydrochloria, Belch, epigastric discomfort, upper abdomen pain, gastric mucosa is congested, and gastral cavilty is glutted, and hyperhydrochloria, appetite is poor, abdominal distension corruption gasteremphraxis, It Deng some related symptoms, and is more difficult to effect a radical cure again, this disease is mostly related with our some eating habits of living.Peptic ulcer Point gastric ulcer and duodenal ulcer, clinical signs are：Upper abdomen pain, it is common to have rhythmicity, periodicity and chronicity The property of feature, pain is often secret anguish, cusalgia, distending pain, hunger pain or severe pain, and the duration of each panic attacks is mostly 1 ~2 hours, also sustainable a few days, while the breaking-out of pain has seasonality, most susceptible disease of general time of the year when autumn changes into winter, gastric ulcer pain hair It is born in postprandial 1/2~2 hour, then is alleviated after 1~2 hour gastric emptying.
Such illness is undoubtedly insufferable for people, although this can be treated by having many stomach medicines to propose Illness, but effect is all less desirable, Western medicine curative effect is fast, but cannot tackle the problem at its root, and Chinese Herbs are slow, taste It is especially bitter, but can be solved the problems, such as from root.And for treating stomach trouble, people are used due to the difference to disease cognitive on earth Chinese medicine or Western medicine, also or the problem of Integrated TCM on, disagreement is again bigger, actually any mode of the selection often at One problem, therefore we need a kind of active drug to solve the above problems.
Invention content
The problem of based on background technology, the present invention propose a kind of Wei-chang-an Capsule and preparation method thereof.
The present invention proposes a kind of Wei-chang-an Capsule, including following raw material：35-38 parts of cuttlebone, fritillaria thunbergii 35-40 Part, 22-26 parts of fructus amomi, 22-28 parts of the bletilla striata, 20-24 parts of corydalis tuber, 35-39 parts of Radix Paeoniae Alba, 5-8 parts of Radix Notoginseng, 22-25 parts of the tuber of pinellia, Pu Public English 25-38 parts, 22-26 parts of dried orange peel, 15-20 parts of Radix Glycyrrhizae.
A kind of Wei-chang-an Capsule and preparation method thereof, includes the following steps：
S1, cleaning：Raw material are collected, cleaning and sterilization is carried out and dries；
S2, crushing：Each raw material is uniformly mixed processed pulverize and sieve and is ground into fine powder；
S3, grinding, polishing：The processed fine powder that is ground into of medicinal material after sieving is packed into polishing of capsules according to fixed proportion.
S4, packaging：The packaged processing of capsule after S3 is processed.
S5, storage：Capsule after packing processes is put into storehouse preservation.
Preferably, it pulverizes and sieves in the S2 and is sieved for No. 6, the proportion of goods damageds of medicinal material are generally can be controlled within 5%.
Preferably, the fine powder after grinding is packed into polishing of capsules by the S3 by fixed proportion.
Preferably, the capsule after the S5 packing processes, deposits in 37 DEG C -40 DEG C, under the conditions of relative humidity 75%.
Because fructus amomi oiliness is stronger in Chinese medicine, individually crushing, sieving are more difficult, after should first being mixed with other medicinal materials, Crushed together with pulverizer again, such crushing effect is preferable, after crossing No. six sieves, the proportion of goods damageds of medicinal material generally can be controlled in 5% with Interior, sieving is packed into capsule.Make to can guarantee that the loss of various medicinal materials substantially reduces when making in this way.
Compared with prior art, the present invention advantageous effect is：
The present invention uses Chinese medicine, doctor trained in Western medicine and the method for the combination of Chinese tradiational and Western medicine, and clinical efficacy is definite, solves patient and buys medicine process The difficult problem of middle selection, while the present invention utilizes modern science means, visits clear taste and substantially combines Chinese medicine modern pharmacology research, To enterogastric diseases differentiation of symptoms and signs for classification of syndrome, cuttlebone, fritillaria thunbergii, the bletilla striata, fructus amomi, corydalis tuber, the tuber of pinellia, Radix Notoginseng, dandelion, white is selected The medicinal materials such as Chinese herbaceous peony, dried orange peel are refined into Wei-chang-an Capsule, have the effect of relieving haperacidity analgesic, regulating qi-flowing for harmonizing stomach.For treating stomach and 12 fingers Epigastric distension and distress caused by enterelcosis, pain, the illnesss such as sour regurgitation, acid regurgitation.
Specific implementation mode
Present invention is further elaborated in following combination specific embodiment.
Embodiment 1
1. the raw material composition and parts by weight of Chinese medicinal capsule active ingredient of the present invention are：
35-38 parts of cuttlebone, 35-40 parts of fritillaria thunbergii, 22-28 parts of the bletilla striata, 20-24 parts of corydalis tuber, 35-39 parts of Radix Paeoniae Alba, three Seven 5-8 parts, 22-25 parts of the tuber of pinellia, 25-38 parts of dandelion, 22-26 parts of dried orange peel, 15-20 parts of Radix Glycyrrhizae, 22-26 parts of fructus amomi.
2. a kind of Wei-chang-an Capsule and preparation method thereof, comprises the following steps that：
(1) by cuttlebone, fritillaria thunbergii, the bletilla striata, corydalis tuber, Radix Paeoniae Alba, Radix Notoginseng, the tuber of pinellia, dandelion, dried orange peel, Radix Glycyrrhizae, fructus amomi medicine Material is cleaned, and containers for future use is put into.
(2) all medicinal materials are individually crushed with pulverizer, is sufficiently mixed uniformly, cross No. six sieves.
(3) the processed levigation of medicinal material after sieving is poured into capsule.Without using the process means such as extraction separation, purifying, place There is no toxicity medicinal material in side, prescription is without incompatibility such as eighteen incompatibilities, nineteen counteractions yet.
(4) packing processes are made, are put in storage.
The oiliness of fructus amomi is stronger in the above medicinal material, individually pulverize and sieve it is relatively difficult, have in process with Other medicinal materials crush again after being sufficiently mixed uniformly.Crushing effect is relatively good.
It is generally can be controlled within 5% by the proportion of goods damageds being sieved with upper type.Sieving is packed into capsule.Make making in this way When can guarantee that the loss of various medicinal materials substantially reduces.
3. the selection of dosage form：The present invention by cuttlebone, fritillaria thunbergii, the bletilla striata, fructus amomi, corydalis tuber, the tuber of pinellia, Radix Notoginseng etc. ten simply Medicine forms, and there is relieving haperacidity analgesic, the functions such as regulating qi-flowing for harmonizing stomach to cure mainly epigastric distension and distress caused by disorder of stomach-energy, pain, sour regurgitation, acid regurgitation Equal diseases, gastric and duodenal ulcer are shown in above-mentioned disorder.With decoction application, clinical effectiveness is definite for original side, but due to decoction decocting, It is inconvenient to carry, it is not easy to patient medication, therefore is fabricated to prescribed preparation.Because each dosing dosage of prescription is smaller, therefore select medicine Material is ground into fine powder and capsule is made, and can retain the active ingredient of crude drug well, and is conducive to patient's long-term use, passes through The further investigation of galenic pharmacy and quality control etc., capsule stable quality, safely, effectively.
4. stability of drug products and safety experiment
(1) capsule that will be made by the above method, respectively establishment are numbered：20031019、20031101、20031118.
(2) reference substance is taken：Ginsenoside Rb1、Rg1And Panax Notoginseng saponin R1Reference substance, Paeoniflorin reference substance are given birth in Chinese drug Tetramune calibrating is bought.
(3) ZF-I types ultraviolet analysis instrument for three purposed；
(4) experiment agents useful for same is taken.Note：Agents useful for same is that analysis is pure in practicality.
(5) by Wei-chang-an Capsule finished product, it is packed into the oral administration solid produced by Hebei province Cang County rehabilitation acceptable packaging material factory In plastic drug package (authentication code is state's pack word 20010073), it is positioned over 37 DEG C -40 DEG C of temperature, relative humidity 75% Under part, in 0 month, January, 2 months, the separately sampled inspection for carrying out indices in March.Experimental method according to《Wei-chang-an Capsule quality Draft standard》It is required that carrying out.
5. detection project is as follows：
1 sample ID of table：Wei-chang-an Capsule lot number：20031019
2 sample ID of table：Wei-chang-an Capsule lot number：20031101
3 sample ID of table：Wei-chang-an Capsule lot number：20031118
6. result：Root Ju we to three batches of sample reserved sample observings of preparation as a result, " Wei-chang-an Capsule " is in appearance character, mirror Not, hygiene, moisture, dissolution etc. all change without conspicuousness, meet the requirement of Wei-chang-an Capsule quality standard, show " Wei-chang-an Capsule " is more stable.In addition, Wei-chang-an Capsule is packed for the medicinal modeling of oral administration solid of Packaging Materials Plant's production Expect bottle, on the quality of capsule without influence, this capsule is stable during experiment, it is ensured that storage life is 1 year.
7. model case is illustrated：
Mr. Wang crosses people from continent, since diet is irregular, suffers from acute gastritis in 2015, which has continued 3 years for a long time, Period takes other drugs and does not take effect.It is discontinued 20 days, takes Wei-chang-an Capsule, abdominal pain mitigates after one week, diarrhea Symptom is also declining, and spirit is also improved, and is continuously taken abdominal pain sense in 2 months and has been disappeared, also not in diarrhea.Take half Nian Hou, acute gastritis symptom already disappear, get well.
Zhang crosses people from continent, and the manual labour diet daily schedule is irregular with gastric ulcer all the year round, also once arrives hospital therapy, still Due to the cause that works, fail to fully recover always, is discontinued two weeks, takes Wei-chang-an Capsule, take two weeks, the appearance of gastric ulcer Cusalgia sense mitigates, and complexion has also been got well much than before.After taking 2 months, the sense of symptom cusalgia completely without, continue to take by 4th month, Check display, illness already disappear.
In conclusion the capsule has effects that treat stomach trouble, and significant effect really.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (5)

1. a kind of Wei-chang-an Capsule, which is characterized in that including following raw material：35-38 parts of cuttlebone, fritillaria thunbergii 35-40 Part, 22-26 parts of fructus amomi, 22-28 parts of the bletilla striata, 20-24 parts of corydalis tuber, 35-39 parts of Radix Paeoniae Alba, 5-8 parts of Radix Notoginseng, 22-25 parts of the tuber of pinellia, Pu Public English 25-38 parts, 22-26 parts of dried orange peel, 15-20 parts of Radix Glycyrrhizae.
2. a kind of preparation method of Wei-chang-an Capsule as claimed in claim 1, which is characterized in that include the following steps：
S1, cleaning：Raw material are collected, cleaning and sterilization is carried out and dries；
S2, crushing：Each raw material is uniformly mixed processed pulverize and sieve and is ground into fine powder；
S3, grinding, polishing：The processed fine powder that is ground into of medicinal material after sieving is packed into polishing of capsules according to fixed proportion.
S4, packaging：The packaged processing of capsule after S3 is processed.
S5, storage：Capsule after packing processes, deposits in storehouse.
3. a kind of Wei-chang-an Capsule according to claim 2 and preparation method thereof, which is characterized in that crushed in the S2 Sieve is No. 6 sieves, and the proportion of goods damageds of medicinal material are generally can be controlled within 5%.
4. a kind of Wei-chang-an Capsule according to claim 2 and preparation method thereof, which is characterized in that after the S3 will be ground Fine powder by fixed proportion be packed into polishing of capsules.
5. a kind of Wei-chang-an Capsule according to claim 2 and preparation method thereof, which is characterized in that the S5 packing processes Capsule afterwards, deposits in 37 DEG C -40 DEG C, under the conditions of relative humidity 75%.
CN201810849006.4A 2018-07-28 2018-07-28 A kind of Wei-chang-an Capsule and preparation method thereof Pending CN108578633A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1100651A (en) * 1994-03-15 1995-03-29 广东医学院医药科技开发中心 Chinese herbal prepn. for curing chronic gastroenteritis and peptic gastric ulcer
CN104056061A (en) * 2014-05-30 2014-09-24 洛阳新火种节能技术推广有限公司 Traditional Chinese medicinal formula for treating gastric ulcer
CN107890539A (en) * 2017-08-15 2018-04-10 程玉峰金章 A kind of Chinese medicine for treating stomach trouble

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1100651A (en) * 1994-03-15 1995-03-29 广东医学院医药科技开发中心 Chinese herbal prepn. for curing chronic gastroenteritis and peptic gastric ulcer
CN104056061A (en) * 2014-05-30 2014-09-24 洛阳新火种节能技术推广有限公司 Traditional Chinese medicinal formula for treating gastric ulcer
CN107890539A (en) * 2017-08-15 2018-04-10 程玉峰金章 A kind of Chinese medicine for treating stomach trouble

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