CN104740313B - One kind treats chronic gastritis Chinese medicine composition and preparation method thereof - Google Patents
One kind treats chronic gastritis Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating chronic gastritis and preparation method thereof, the Chinese medicine composition is made up of the raw material of following weight proportion：150 parts of Radix Codonopsis, 100 parts of Poria cocos, 100 parts of the bighead atractylodes rhizome, 100 parts of the root of herbaceous peony, 150 parts of the red sage root, 100 parts of the radix paeoniae rubrathe, 100 parts of bletilla, 20 parts of rheum officinale, 60 parts of the banksia rose, 100 parts of Fructus meliae toosendan, 100 parts of dark plum, 10 parts of indigo naturalis；And after being extracted according to certain process, with acceptable auxiliary material in pharmacy and manufactured oral preparation of Chinese traditional medicinal.Chinese medicine composition of the present invention has preparation technology simple possible, safe and effective, pharmacological effect effect is obvious, clinical effectiveness outstanding feature.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for treating chronic gastritis and preparation method thereof, belongs to pharmaceutical preparations technology neck
Domain.
Background technology
Chronic gastritis is common clinical, and the incidence of disease is higher.Its clinical characters is that the course of disease is long, touching refractory, to patient
Live and work bring inconvenience, can also develop into individually gastric precancerous lesion even stomach cancer, threat to life health.It is clinical
Common patient has indigestion performance, such as sour regurgitation, belch, early satiety, anorexia, nausea symptom.Atrophic gastritis can
To there is obvious apocleisis and weight loss, and with anaemia.Chronic gastritis is damaged repeatedly by a variety of adverse factors, causes stomach to glue
The chronic inflammatory diseases of film.It is now recognized that this sick generation and acute gastritis, infection of the upper respiratory tract focus, thermophilic tobacco and wine, diet are not
When, bile regurgitation, gastric anacidity, malnutrition, autoimmune response and chronic drug stimulate and helicobacter pylori infection infected with
Close.Clinically regular epigastric distension and distress, stomachache, belch, acid regurgitation or poor appetite etc. are main performance.It is divided into by histology chronic
Superficial gastritis, atrophic gastritis and the class of hypertrophic gastritis three.Superficial gastritis can change into atrophic gastritis or with withering
Contracting gastritis is simultaneously deposited, and a small number of atrophic gastritis can develop into stomach cancer again.For chronic gastritis, most of Western medicine can only be temporary transient
Relief of symptoms, illness can not be eradicated, long-term use can produce certain dependence and the resistance to the action of a drug, and side effect is larger.And this
Invention offer one kind treats chronic gastritis, and clinically application aspect has significant curative effect, and the less Chinese traditional medicine composition of toxic side effect
Thing.
The traditional Chinese medical science thinks that chronic gastritis is one kind disease with the characteristics of illness is longer with the characteristics of gastral cavilty portion pain recurrent exerbation
Disease, category traditional Chinese medicine " gastral cavilty disease ", " stomach ruffian " category.In the cause of disease, weakness of the spleen and the stomach is its internal factor, eating and drinking without temperance, feelings will
Hinder, work and rest is excessive, inward invasion of pathogenic cold is its risk factor.Eating and drinking without temperance, it is stagnant not change, it is strongly fragrant to hold back mechanism of qi；It is worried angry, liver, which is lost, to be dredged
Let out, stagnation of the circulation of vital energy gastral cavilty；Excessively pungent old then wasting QI-blood, then mechanism of qi does not relax excessive idleness；Inward invasion of pathogenic cold, stagnate gastral cavilty, emptiness of spleen and stomach,
In addition above factors cause functional activity of QI being not smooth, and stasis gastral cavilty, disturbance in ascending and descending is this sick basic pathogenesis.This disease produces more because cold-evil coagulates
Caused by stagnant, stagnation of QI due to depression of the liver, damp and hot interior Sheng, intemperance of taking food.Treat to have in this sick Zhang Zhongjing " banxia xiexin decoction " and pungent open bitter drop, fever and chills
And adjust, the method that tonification and purgation in combination, treat the stomach ruffian clearly side's of sending medication consideration for later age.In Qing Dynasty Lee《Zhengzi Huibu feeling of fullness》In it is right
" this sick treatment, just suitable Shu Yu, resolving sputum, fall fire, preferably consolidate middle gas assistant with his medicine long；There is phlegm to control phlegm, there is fire to relieve inflammation or internal heat, Yu Zejian
Change." traditional Chinese medicine composition for treating of the present invention is weakness of the spleen and the stomach, qi stagnation blood stasis chronic gastritis have the effect of definite.
Radix Codonopsis has tonifying spleen benefit stomach effect, red sage root promoting blood circulation and cooling blood in we, and myogenic is put on flesh, and two medicine compatibilities, qi and activate blood circulation stops
Bitterly, it is altogether monarch drug in a prescription.The bighead atractylodes rhizome replenishes qi to invigorate the spleen eliminating dampness, to help Radix Codonopsis；Banksia rose promoting qi circulation and relieving pain, a, gas one blood compatible with the red sage root, adjust smooth
Qi and blood；Root of herbaceous peony relieving spasm to stop pain；Rheum officinale heat clearing and blood circulation promoting.To help the red sage root, above-mentioned four taste aids in monarch drug in a prescription air making-up and spleen enlivening, heat clearing and blood circulation promoting, and
Promoting qi circulation and relieving pain is monarch drug in a prescription altogether.Poria cocos invigorating the spleen excreting dampness with help the bighead atractylodes rhizome, indigo naturalis, the radix paeoniae rubrathe coordinate the red sage root, rheum officinale cooling and activating blood, melia toosendan sub-line
Gas relieves pain, and bletilla helps red sage root detumescence and promoting granulation；Dark plum reinforcing stomach reg fluid, stomach-Yin is damaged to prevent the dry medicine of all hardships.It is adjutant with Six-element.
All medicine phases are matched somebody with somebody, and reinforcing and reducing methods is used in combination, and qi and blood is simultaneously controlled, giving consideration to both the incidental and fundamental, and righting is evil without loving, and gets rid of evils without hindering just, temper is good for, qi and blood
Unobstructed, heat symptoms caused by an exopathgen must be dropped, and abdominal distention, weak, bitter taste, all cards of halitosis can be cured.Therefore we have strengthening the spleen and stomach, vital energy regualting and blood circulation-promoting
Effect, clinically for incoordination between the spleen and the stomach caused Upper abdominal pain, feeling of fullness receives difference and the illness such as chronic gastritis has significant treatment
Effect.
The content of the invention
Present invention aims at provide it is a kind of it is convenient to take, toxic side effect is small, steady quality, curative effect reliably treat it is chronic
The Chinese medicine composition and its preparation method of gastritis.
The technical scheme is that a kind of Chinese medicine composition for being used to treat chronic gastritis, by the raw material of following parts by weight meter
Composition：It is 150 parts of Radix Codonopsis, 100 parts of Poria cocos, 100 parts of the bighead atractylodes rhizome, 100 parts of the root of herbaceous peony, 150 parts of the red sage root, 100 parts of the radix paeoniae rubrathe, 100 parts of bletilla, big
Yellow 20 parts, 60 parts of the banksia rose, 100 parts of Fructus meliae toosendan, 100 parts of dark plum, 10 parts of indigo naturalis；
Above-mentioned medicinal material is prepared with following processing step：
(1) indigo naturalis, the red sage root are ground into fine powder, it is standby；
(2) the bighead atractylodes rhizome, banksia rose medicinal material are taken, it is that 9~12 times of amount water soak 1 hour to add medicinal material weight ratio, steam distillation 1~
2h, volatile oil is collected, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 4~7 times of amounts, stir, refrigerate, filter, filter
Cross thing after drying, produce inclusion compound, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and be ground into dried cream powder,
The dregs of a decoction are standby；
(3) rheum officinale, Fructus meliae toosendan medicinal material are taken, adds medicinal material weight ratio as 7~10 times of 50%~80% ethanol of amount, refluxing extraction 1~
3 times, 0.5~2h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dry cream every time
Powder, sieving, the dregs of a decoction are standby；
(4) the dregs of a decoction of step (2) and (3) are merged with Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material again, added and medicine
Material weight for the decocting of 8~11 times of amounts than being boiled 1~3 time, and 0.5~2h, is filtered, merging filtrate, be concentrated under reduced pressure drying, and powder every time
Dried cream powder is broken into, it is standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and step (2) middle inclusion compound, it is fully mixed
After even, Traditional Chinese drug mixture is produced, the auxiliary material commonly used in pharmacy is added and various different oral formulations is made, produce.
Wherein preferable preparation method is realized by following steps：
(1) indigo naturalis, the red sage root are ground into fine powder, it is standby；
(2) the bighead atractylodes rhizome, banksia rose medicinal material are taken, and it is that 10 times of amount water soak 1 hour, steam distillation 1.5h to add medicinal material weight ratio, is received
Collect volatile oil, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 6 times of amounts, stir, refrigerate, filter, permeate is through dry
After dry, inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction are standby；
(3) rheum officinale, Fructus meliae toosendan medicinal material are taken, adds medicinal material weight ratio as 8 times of 70% ethanol of amount, refluxing extraction 2 times, each 1h,
Filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dried cream powder, sieve, the dregs of a decoction are standby
With；
(4) the dregs of a decoction of step (2) and (3) are merged with Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material again, dosing material
Weight filters, merging filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby than being boiled 2 times, each 1h for the decocting of 10 times of amounts
With；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing,
Traditional Chinese drug mixture is produced, the auxiliary material commonly used in pharmacy is added and various different oral formulations is made, produce.
Oral formulations made of technical solution of the present invention can be granule, hard capsule, tablet or pill.
Granule：By gained Traditional Chinese drug mixture, with appropriate dextrin, sucrose, mix, pelletize, dry, granule is made.
Hard capsule：By gained Traditional Chinese drug mixture, suitable auxiliary material is added, is pelletized, it is encapsulated, hard capsule is made.
Pill：By gained Traditional Chinese drug mixture, heat, stir with suitable matrix, and carry out dripping, dripping pill is made
Agent.
Tablet：By gained Traditional Chinese drug mixture, mixed with appropriate amount of starch, dextrin, granulation is tabletted.
The present invention is among practical study process, and the main creation point of technical scheme is the extraction process of medicinal material, thus
Significant technological progress is brought, it is main to have the beneficial effect that：
The Chinese medicine composition of the present invention is made up of the taste Chinese medicine of Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, red sage root etc. 12, in order to improve
Active ingredient dissolution rate and bioavilability in crude drug, select different extracting methods；In our Chinese medicine indigo naturalis mainly into
Dividing indigo and indigo red, it is danshensu and tanshinone IIA to contain water-soluble and liposoluble constituent in red rooted salvia, but due to original
Production technology, using decocting heating extraction, the extraction of the fat-soluble active ingredient wherein in the red sage root is not complete enough, and tanshinone
II A is heated to be lost, and Given this we are crushed red rooted salvia, are advantageous to retain its active principle；The bighead atractylodes rhizome, banksia rose medicinal material
In containing Baizhu volatile oil and containing volatile oil compositions such as dehydro-α-curcumene, costunolides, therefore carried using steam distillation
Take, in order to prevent volatile oil from being lost in formulation manufacturing processes, using beta-cyclodextrin inclusion compound into drug powder, it is stable to increase it
Property；Containing compositions such as anthraquinone, diphenylethylene and melia toosendan seed total flavonoids in rheum officinale, Fructus meliae toosendan medicinal material in side, it has in ethanol
Preferable solubility property, therefore use alcohol reflux to extract；Contain Radix Codonopsis terpene in Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material
The compositions such as class, glycoside, Paeoniflorin, bletilla polysaccharide, dark plum acid, dark plum polysaccharide and pachymaran, these active principles are in water
Solubility property is good, therefore uses water boiling and extraction.In order to greatest extent that extracts active ingredients in medicinal material are complete, therefore will be carried through ethanol
The hydration of the medicinal material such as the dregs of a decoction and Radix Codonopsis is pan-fried after taking and after steam distillation extracts, and according to above-mentioned preparation technology, obtained Chinese medicine carries
Take thing that there is significant therapeutic effect.
In a word, extraction and preparation technique of the invention and the technical scheme of shaping be us reality research process,
By it is unremitting grope it is rational to plan as a whole, compare with accidental discovery, and the clinical practice demand for said preparation of comprehensively having investigated
And the process route drawn, so as to ensure that the science for the Chinese medicine composition being finally made and validity.
It is that pharmacodynamic study experiment is carried out to the medicine that technical solution of the present invention obtains below, because the core of the present invention is created
In terms of new point is the extraction and preparation technique of medicinal material, the pharmacodynamics for sufficiently illustrating drug therapy chronic gastritis of the present invention is treated
Effect.With reference to the research level of modern pharmacology, work of the medicine of the present invention to rat model gastric juice free acidity, pepsin is studied
Property and rat blood serum in the experiment such as gastrin changes of contents, in order to simplify experimental implementation, save research expenditure, it then follows parallel right
According to experiment principle, each medicine group is got rid of because of the effect of Dosage Form Factors are brought difference in itself, so as to more this hair of the protrusion of science
The creativeness of bright technical scheme, but thus this can be derived completely for those skilled in the art, understand other in the application
The beneficial effect of parameter point technical scheme, therefore the technology of the present invention content and pharmacodynamic results are never limited to this scope.
1 test material and method：
The preparation of 1.1 trial drugs：
A. the preparation of medicine centre of the present invention product group：
(1) indigo naturalis 10g, red sage root 150g are ground into fine powder, it is standby；
(2) bighead atractylodes rhizome 100g, banksia rose 60g medicinal materials are taken, and it is that 10 times of amount water soak 1 hour to add with medicinal material weight ratio, steam distillation
1.5h, volatile oil is collected, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 6 times of amounts, stir, refrigerate, filter, filtration
Thing after drying, produces inclusion compound, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, medicine
Slag is standby；
(3) rheum officinale 20g, Fructus meliae toosendan 100g medicinal materials are taken, adds medicinal material weight ratio as 8 times of 70% ethanol of amount, refluxing extraction 2 times,
Each 1h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dried cream powder, sieve,
The dregs of a decoction are standby；
By the step dregs of a decoction (2) and (3) again with Radix Codonopsis 150g, root of herbaceous peony 100g, radix paeoniae rubrathe 100g, bletilla 100g, dark plum 100g,
Poria cocos 100g medicinal materials merge, and dosing material weight filters, merging filtrate, decompression is dense than being boiled 2 times, each 1h for the decocting of 10 times of amounts
Contracting drying, and dried cream powder is ground into, it is standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing,
Traditional Chinese drug mixture is produced, before use, adds distilled water to be configured to suspension decoction, produces.
B. the preparation of control group medicine：
Gastral cavilty relaxation grain is taken, before use, adds distilled water to be configured to the suspension with product group equivalent concentration among medicine of the present invention
Decoction, produce.
1.2 experimental animal：Wistar rats, male and female dual-purpose body weight are 180~220g, are ground purchased from The Fourth Military Medical University's experiment
Study carefully center.
1.3 statistical procedures：Experimental result withRepresent, examined using t, determine the conspicuousness of group difference.
2. the test of pesticide effectiveness and result：
Rat 60 is taken, male and female half and half, is randomly divided into the 1st, 2,3,4 group, respectively Normal group, model group, the positive
Product group among drug control group, medicine of the present invention, every group 15, except the rat of Normal group gives physiological saline, remaining is each
Group rat carries out modeling, i.e., gavages 60% ethanol 2ml/ every time only every 10d within 1st month, and 20mmol/L deoxysodium cholate is molten
Liquid is arbitrarily drunk as beverage, the 2nd, 3 month every 7d respectively to drinking 30% ethanol and 10mmol/L deoxysodium cholate is molten
Liquid, before modeling terminates, extract a small number of animals and make pathology of gastric mucosa histological examination, after confirming the success of chronic gastritis model, take and make
Rat after mould success, every group randomly selects 10, the 1st group and 2 groups of rats give isometric physiological saline respectively, the 3rd group
Gastral cavilty relaxation grain is given respectively and the 4th group is given product group among the present invention, and dosage is 2.89g/kg, one time a day, continuously
42d.Water 24h is can't help in fasting before rat experiment, and dislocation is put to death, wins full stomach, gastral cavity is splitted along greater curvature portion, with 6mL distilled water
Gastral cavity is rinsed, after liquid centrifugation to be cleaned, takes supernatant, with titration measuring gastric juice free acidity, stomach egg is determined with wheat Te Shi methods
White enzymatic activity；Each group animal fasting 12h after last dose, broken end take blood 4ml to be placed in test tube, and with 3000r/min, centrifugation
5min, separation serum preserve at -20 DEG C, using radioimmunology, determine the content of gastrin, the results are shown in Table 1.
Influence of the table 1 to chronic gastritis rat digestive function
Note：Compared with after normal group treatment,■■■P<0.001,■■P<0.01,■P<0.05；Compare after being treated with model group
Compared with * * P<0.01,*P<0.05.
From the results showed that of table 1 compared with normal group control group, free acidity and stomach cardia in model group rats gastric juice
Gastrin content is respectively provided with significant otherness in enzyme and serum（P<0.01）, this illustrates the modeling method employed in this experiment
It is successful；Compared with model group, product group can significantly improve the stomach egg of rat with control group medicine among medicine of the present invention
White enzymatic activity（P<0.01）, and gastric juice free acidity and gastrin content also increased（P<0.05）, medicine of the present invention
The effect of middle product group, is better than control group medicine（Gastral cavilty relaxation grain）.
In summary, product group has free acidity and enhancing stomach cardia in rise experimental rat gastric juice among medicine of the present invention
Effect, these effects such as gastrin content are to treat the pharmacology of chronic gastritis disease in the activity and increase rat blood serum of enzyme
Basis, it can be seen that, medicine of the present invention has prominent beneficial effect.
Embodiment
It is the specific embodiment of present invention below, is solved the skill of technical problem in present specification for illustrating
Art scheme, contribute to skilled artisan understands that present invention, but the realization of technical solution of the present invention is not limited to these
Embodiment.
Embodiment 1
(1) indigo naturalis 10g, red sage root 150g are ground into fine powder, it is standby；
(2) bighead atractylodes rhizome 100g, banksia rose 60g medicinal materials are taken, and it is that 10 times of amount water soak 1 hour to add with medicinal material weight ratio, steam distillation
1.5h, volatile oil is collected, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 6 times of amounts, stir, refrigerate, filter, filtration
Thing after drying, produces inclusion compound, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, medicine
Slag is standby；
(3) rheum officinale 20g, Fructus meliae toosendan 100g medicinal materials are taken, adds medicinal material weight ratio as 8 times of 70% ethanol of amount, refluxing extraction 2 times,
Each 1h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dried cream powder, sieve,
The dregs of a decoction are standby；
By the step dregs of a decoction (2) and (3) again with Radix Codonopsis 150g, root of herbaceous peony 100g, radix paeoniae rubrathe 100g, bletilla 100g, dark plum 100g,
Poria cocos 100g medicinal materials merge, and dosing material weight filters, merging filtrate, decompression is dense than being boiled 2 times, each 1h for the decocting of 10 times of amounts
Contracting drying, and dried cream powder is ground into, it is standby；
(5) take it is above-mentioned (1) in medicinal powder, step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing, produce
Traditional Chinese drug mixture, with appropriate dextrin, sucrose, mix, pelletize, dry, 1000g granules are made.
Embodiment 2
(1) indigo naturalis 10g, red sage root 150g are ground into fine powder, it is standby；
(2) bighead atractylodes rhizome 100g, banksia rose 60g medicinal materials are taken, adds and is soaked 1 hour with than 9 times amount water of medicinal material weight, steam distillation
1.5h, volatile oil is collected, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 4 times of amounts, stir, refrigerate, filter, filtration
Thing after drying, produces inclusion compound, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, medicine
Slag is standby；
(3) rheum officinale 20g, Fructus meliae toosendan 100g medicinal materials are taken, adds medicinal material weight ratio as 7 times of 60% ethanol of amount, refluxing extraction 2 times,
Each 2h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dried cream powder, sieve,
The dregs of a decoction are standby；
By the step dregs of a decoction (2) and (3) again with Radix Codonopsis 150g, root of herbaceous peony 100g, radix paeoniae rubrathe 100g, bletilla 100g, dark plum 100g,
Poria cocos 100g medicinal materials merge, and dosing material weight filters, merging filtrate, decompression is dense than being boiled 3 times, each 0.5h for the decocting of 9 times of amounts
Contracting drying, and dried cream powder is ground into, it is standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing,
Traditional Chinese drug mixture is produced, is mixed with appropriate amount of starch, dextrin, granulation, is pressed into 1000 tablets.Embodiment 3
(1) indigo naturalis 10g, red sage root 150g are ground into fine powder, it is standby；
(2) bighead atractylodes rhizome 100g, banksia rose 60g medicinal materials are taken, adds and is soaked 1 hour with than 11 times amount water of medicinal material weight, steam distillation
2h, volatile oil is collected, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 5 times of amounts, stir, refrigerate, filter, permeate
After drying, inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction
It is standby；
(3) rheum officinale 20g, Fructus meliae toosendan 100g medicinal materials are taken, adds medicinal material weight ratio as 10 times of 50% ethanol of amount, refluxing extraction 3 times,
Each 0.5h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dried cream powder, mistake
Sieve, the dregs of a decoction are standby；
By the step dregs of a decoction (2) and (3) again with Radix Codonopsis 150g, root of herbaceous peony 100g, radix paeoniae rubrathe 100g, bletilla 100g, dark plum 100g,
Poria cocos 100g medicinal materials merge, and dosing material weight filters, merging filtrate, decompression than being boiled 1 time, each 1.5h for the decocting of 11 times of amounts
It is concentrated and dried, and is ground into dried cream powder, it is standby；
(5) take it is above-mentioned (1) in medicinal powder, step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing, produce
Traditional Chinese drug mixture, suitable auxiliary material is added, pelletized, it is encapsulated, 1000 hard capsules are made.Embodiment 4
(1) indigo naturalis 10g, red sage root 150g are ground into fine powder, it is standby；
(2) bighead atractylodes rhizome 100g, banksia rose 60g medicinal materials are taken, adds and is soaked 1 hour with than 12 times amount water of medicinal material weight, steam distillation
1h, volatile oil is collected, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 7 times of amounts, stir, refrigerate, filter, permeate
After drying, inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction
It is standby；
(3) rheum officinale 20g, Fructus meliae toosendan 100g medicinal materials are taken, adds medicinal material weight ratio as 9 times of 80% ethanol of amount, refluxing extraction 1 time,
Each 1.5h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dried cream powder, mistake
Sieve, the dregs of a decoction are standby；
By the step dregs of a decoction (2) and (3) again with Radix Codonopsis 150g, root of herbaceous peony 100g, radix paeoniae rubrathe 100g, bletilla 100g, dark plum 100g,
Poria cocos 100g medicinal materials merge, and dosing material weight is filtered, merging filtrate, is concentrated under reduced pressure than being boiled 2 times, each 2h for the decocting of 8 times of amounts
Dry, and be ground into dried cream powder, it is standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing,
Traditional Chinese drug mixture is produced, heats, stirs with suitable matrix, and carries out dripping, 1000g dripping pills are made.
The effect of in order to further verify finished product preparation of the present invention, we will be prepared in above-mentioned specific embodiment 1-4 into
Product granule, tablet, hard capsule and pill medicine have carried out corresponding clinical test, are now reported as follows result.
Clinical observation and curative effect
1. general information：
In July, 2008~2010 year May is collected in the tested case of the court patient 151, as research object, wherein male
83, women 68；Age be 23~58 years old, average age (48.72 ± 1.31) year；The course of disease 6 months~3 years, average course of disease
(2.35 ± 0.41) year；It is randomly divided into 5 groups, wherein embodiment 1 group 34, embodiment 2 group 29, embodiment 3 group 31, implementation
Example 4 group 27, control group（Weiwanshu granule medicament group）30, all patients according to age, sex, the course of disease, clinical symptoms etc.,
Each group there are no significant in terms of general information difference, has comparativity.
Diagnostic criteria:Reference《Traditional Chinese medical science disease diagnosis and treatment standard and with prescription select》And《Common disease diagnosis basis is sentenced with curative effect
Disconnected diagnosis》:Gastrocopy finds gastric mucosa congestion oedema, ulcer surface and blutpunkte, rotten to the corn point.Stomach lining and gastric juice urease are fast
Speed diagnosis test paper method test helicobacter pylori (HP) is the positive.With gastral cavilty portion distending pain, repeatedly burning heat sensation, acid regurgitation, hiccup etc.
Digestive symptoms etc., meet above-mentioned condition, you can are diagnosed as chronic gastritis and make a definite diagnosis.
2. treatment method
1 group of the oral embodiment of the present invention for the treatment of group, 2 groups, 3 groups, 4 groups of medicines, each taking 4 dosage units, daily 2
It is secondary；The oral gastral cavilty relaxation grain of control group, 2 times a day, 1 bag every time, continuously took 3 courses for the treatment of with 4 weeks for a course for the treatment of.Control
During treatment, coordinate the conditionings such as certain diet, psychology and work and rest custom.
3. therapeutic evaluation
It is effective：After treatment, helicobacter pylori checks feminine gender, and clinical symptoms and sign recover normal, fibergastroscopy stomach
Mucous membrane foci disappearance.Effectively：After treatment, helicobacter pylori checks feminine gender, and clinical symptoms and sign are improved in varying degrees, fiber
Gastrocopy gastric mucosa focus has different degrees of improvement.It is invalid：After treatment, helicobacter pylori checks positive, clinical symptoms, sign
With gastric mucosa focus it is unchanged or aggravate.
3.1 result of the tests are shown in Table 2.
Each test group clinical effectiveness statistics of table 2
After drug therapy of the results showed that of table 2 by 3 courses for the treatment of, its most of Patients with Chronic Gastritis, occur
Sour regurgitation, belch, anorexia, nausea, belly distending pain, the symptom such as hiccup all improve significantly, and helicobacter pylori checks
For feminine gender, gastric mucosa focus has different degrees of improvement.1 group of the embodiment of the present invention, 2 groups, 3 groups, 4 groups of total effective rates be respectively
79.4%th, 75.9%, 74.2%, 77.8%, wherein, it is optimal the effect of 1 group of the embodiment of the present invention, and control group Weiwanshu granule medicament
The effective percentage of group is only 56.7%, the results showed that, Chinese medicine composition prepared by technical solution of the present invention is in terms of gastritis disease is treated
Clinical efficacy it is notable, and be better than Weiwanshu granule medicament group, and over the course for the treatment of, do not find each test group medicine not
Good reaction.
As a result showing, Chinese medicine composition of the invention has the advantages that preparation technology simple possible, curative effect are reliable and stable, its
No matter beneficial effect is from the preparing technique process of medicinal material, or on the forming technique of finished product preparation, it is effectively guaranteed that this hair
The excellent results of bright Chinese medicine composition, this further proves that Chinese medicine composition of the present invention is that a kind of curative effect is reliable, safely and effectively
The medicine of chronic gastritis is treated, there is huge market potential, is worth further genralrlization.
Claims (7)
1. a kind of Chinese medicine composition for treating chronic gastritis, it is made up of the bulk drug of following weight proportion：150 parts of Radix Codonopsis,
100 parts of Poria cocos, 100 parts of the bighead atractylodes rhizome, 100 parts of the root of herbaceous peony, 150 parts of the red sage root, 100 parts of the radix paeoniae rubrathe, 100 parts of bletilla, 20 parts of rheum officinale, the banksia rose 60
Part, 100 parts of Fructus meliae toosendan, 100 parts of dark plum, 10 parts of indigo naturalis；Characterized in that, the Chinese medicine composition is prepared by following processing steps
Form：
(1) indigo naturalis, the red sage root are ground into fine powder, it is standby；
(2) the bighead atractylodes rhizome, banksia rose medicinal material are taken, and it is that 9~12 times of amount water soak 1 hour, 1~2h of steam distillation to add medicinal material weight ratio, is received
Collect volatile oil, add the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 4~7 times of amounts, stir, refrigerate, filter, permeate warp
After drying, inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction are standby
With；
(3) rheum officinale, Fructus meliae toosendan medicinal material are taken, adds medicinal material weight ratio as 7~10 times of 50%~80% ethanol of amount, refluxing extraction 1~3
Secondary, 0.5~2h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dry cream every time
Powder, sieving, the dregs of a decoction are standby；
(4) the dregs of a decoction of step (2) and (3) are merged with Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material again, added and medicinal material weight
Amount for the decocting of 8~11 times of amounts than being boiled 1~3 time, and 0.5~2h, is filtered, merging filtrate, be concentrated under reduced pressure drying, and is ground into every time
Dried cream powder, it is standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and step (2) middle inclusion compound, after fully mixing,
Traditional Chinese drug mixture is produced, the auxiliary material commonly used in pharmacy is added and various different oral formulations is made, produce.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that it is prepared by following processing steps：
(1) indigo naturalis, the red sage root are ground into fine powder, it is standby；
(2) the bighead atractylodes rhizome, banksia rose medicinal material are taken, and it is that 10 times of amount water soak 1 hour to add medicinal material weight ratio, and steam distillation 1.5h, collection is waved
Hair oil, add volatilization weight of oil be 6 times amount beta-schardinger dextrin saturated aqueous solutions, stir, refrigerate, filter, permeate after drying,
Inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction are standby；
(3) rheum officinale, Fructus meliae toosendan medicinal material are taken, and it is 8 times of 70% ethanol of amount to add medicinal material weight ratio, refluxing extraction 2 times, each 1h, is filtered
Cross, merging filtrate simultaneously reclaims ethanol to after without alcohol taste, after decoction is concentrated and dried, and is ground into dried cream powder, sieves, the dregs of a decoction are standby；
(4) the dregs of a decoction of step (2) and (3) are merged with Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material again, dosing material weight
Than being boiled 2 times, each 1h for the decocting of 10 times of amounts, filter, merging filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing, produce
Traditional Chinese drug mixture, add the auxiliary material commonly used in pharmacy and various different oral formulations are made, produce.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that the Chinese medicine composition is granule, tablet, ebonite
Wafer or pill.
4. the preparation method of Chinese medicine composition as claimed in claim 1, it is characterised in that：
A raw material composition and ratio：150 parts of Radix Codonopsis, 100 parts of Poria cocos, 100 parts of the bighead atractylodes rhizome, 100 parts of the root of herbaceous peony, 150 parts of the red sage root, the radix paeoniae rubrathe 100
Part, 100 parts of bletilla, 20 parts of rheum officinale, 60 parts of the banksia rose, 100 parts of Fructus meliae toosendan, 100 parts of dark plum, 10 parts of indigo naturalis；
B operates the raw material in A as follows：
(1) indigo naturalis, the red sage root are ground into fine powder, it is standby；
(2) the bighead atractylodes rhizome, banksia rose medicinal material are taken, and than 9~12 times amount water of dosing material weight are soaked 1 hour, and 1~2h of steam distillation, collection is waved
Hair oil, the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 4~7 times of amounts is added, stirs, refrigerates, filter, permeate is through drying
Afterwards, inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction are standby；
(3) rheum officinale, Fructus meliae toosendan medicinal material are taken, adds medicinal material weight ratio as 7~10 times of 50%~80% ethanol of amount, refluxing extraction 1~3
Secondary, 0.5~2h, filtration, merging filtrate simultaneously reclaim ethanol to after without alcohol taste, after decoction is concentrated and dried, and are ground into dry cream every time
Powder, sieving, the dregs of a decoction are standby；
(4) the dregs of a decoction of step (2) and (3) are merged with Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material again, dosing material weight
Than being boiled 1~3 time for the decocting of 8~11 times of amounts, 0.5~2h, is filtered, merging filtrate, be concentrated under reduced pressure drying, and is ground into dry every time
Cream powder, it is standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing, produce
Traditional Chinese drug mixture, add the auxiliary material commonly used in pharmacy and various different oral formulations are made, produce.
5. the preparation method of Chinese medicine preparation as claimed in claim 4, it is characterised in that：Step (4) in manufactured oral formulations be
Granule, tablet, hard capsule or pill.
6. the preparation method of Chinese medicine composition as claimed in claim 4, it is characterised in that：
(1) indigo naturalis, the red sage root are ground into fine powder, it is standby；
(2) the bighead atractylodes rhizome, banksia rose medicinal material are taken, and it is that 10 times of amount water soak 1 hour, steam distillation 1.5h to add with medicinal material weight ratio, is collected
Volatile oil, the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 6 times of amounts is added, stirs, refrigerates, filter, permeate is through drying
Afterwards, inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction are standby；
(3) rheum officinale, Fructus meliae toosendan medicinal material are taken, and it is 8 times of 70% ethanol of amount to add medicinal material weight ratio, refluxing extraction 2 times, each 1h, is filtered
Cross, merging filtrate simultaneously reclaims ethanol to after without alcohol taste, after decoction is concentrated and dried, and is ground into dried cream powder, sieves, the dregs of a decoction are standby；
(4) the dregs of a decoction (2) and (3) are merged with Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material again, dosing material weight ratio is
The decocting of 10 times of amounts is boiled 2 times, each 1h, is filtered, merging filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(5) take it is above-mentioned (1) in medicinal powder, (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing, produce Chinese medicine mixing
Thing, add the auxiliary material commonly used in pharmacy and various different oral formulations are made, produce.
7. the preparation method of Chinese medicine composition as claimed in claim 4, it is characterised in that：
(1), by indigo naturalis, the red sage root, fine powder is ground into, it is standby；
(2) the bighead atractylodes rhizome, banksia rose medicinal material are taken, and it is that 10 times of amount water soak 1 hour, steam distillation 1.5h to add with medicinal material weight ratio, is collected
Volatile oil, the beta-schardinger dextrin saturated aqueous solution that volatilization weight of oil is 6 times of amounts is added, stirs, refrigerates, filter, permeate is through drying
Afterwards, inclusion compound is produced, by the aqueous solution after distillation, filtration, after filtrate is concentrated and dried, and is ground into dried cream powder, the dregs of a decoction are standby；
(3) rheum officinale, Fructus meliae toosendan medicinal material are taken, and it is 8 times of 70% ethanol of amount to add medicinal material weight ratio, refluxing extraction 2 times, each 1h, is filtered
Cross, merging filtrate simultaneously reclaims ethanol to after without alcohol taste, after decoction is concentrated and dried, and is ground into dried cream powder, sieves, the dregs of a decoction are standby；
(4) the dregs of a decoction of step (2) and (3) are merged with Radix Codonopsis, the root of herbaceous peony, the radix paeoniae rubrathe, bletilla, dark plum, Poria cocos medicinal material again, dosing material weight
Than being boiled 2 times, each 1h for the decocting of 10 times of amounts, filter, merging filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(5) the medicinal powder in taking above-mentioned steps (1), step (2), (3), (4) in dried cream powder and (2) middle inclusion compound, after fully mixing, produce
Traditional Chinese drug mixture, with appropriate dextrin, sucrose, mix, pelletize, dry, granule is made.
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