CN108578278A - A kind of edible lipstick and preparation method thereof contributing to weight-reducing - Google Patents
A kind of edible lipstick and preparation method thereof contributing to weight-reducing Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
- A61Q1/06—Lipsticks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
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Abstract
The invention discloses a kind of edible lipsticks and preparation method thereof contributing to weight-reducing, are prepared from the following raw materials in parts by weight：300 500 parts of Brazil wax, 200 400 parts of candelila wax, 50 80 parts of olive oil, 50 80 parts of Sweet Almond Oil, 50 80 parts of sunflower seed oil, 50 80 parts of grape seed oil, 50 80 parts of shea butter, 100 150 parts of natural VE, 150 200 parts of beeswax, 400 400 parts of red sorghum pigment.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to it is a kind of contribute to weight-reducing edible lipstick and its preparation side
Method.
Background technology
Lipstick is the big sharp weapon that women highlights complexion, lip can be allowed ruddy glossy, increases facial aesthetic feeling.However, existing
Artificial color in lipstick on the market, lipstick may be converted into Mutagen, lead to cancer simultaneously under ultraviolet light irradiation
And the lanolin in lipstick has stronger adsorptivity, can all be attached on the mucous membrane of lip the dust in air, bacterium, eat
When substance harmful to health will be taken in the mouth, into we in vivo.The huge sum of money such as the lead containing higher amount, cadmium in lipstick
Belong to, lead has accumulative, and the long-term human body that sucks probably can lead to chronic lead poisoning, cause anaemia, abdominal pain, acute renal failure and brain
The problems such as neuropathy.
N-octacosanol (Octacosanol), popular name：Montanylalcohol (Montanylalcohol), Japan are known as Ocatacosanol
(Koranylalcohol).Molecular formula is C28H58O, appearance are white powder or flakey crystal, 81-83 DEG C of molten point, proportion
0.1783 (85 DEG C) dissolve in the organic solvents such as hot ethanol, ether, benzene, toluene, chloroform, dichloromethane, petroleum ether, do not dissolve in
Water.It is nonhygroscopic to acid, alkali, reducing agent, light, thermostabilization.In addition, people specialize in the toxicity of octacosanol, lead to
Crossing acute toxicity test confirms white mouse LD50=18000mg/kg (white mouse is oral), safety (salt LD50=higher than salt
3000mg/kg).In research n-octacosanol in the effect test of rat lipid metabolism high in fat, adding n-octacosanol group
The total cholesterol of middle rat and the content of low density lipoprotein cholesterol all significantly reduce, and are in dose dependent, and highly dense
The content for spending lipoprotein cholesterol is then constant, and the weight of the greasiness tissue in kidney week is remarkably decreased, and cell number does not subtract
It is few, show that n-octacosanol may inhibit the accumulation of lipid in the tissue, and for the fat in epididymis greasiness matter tissue and liver
Content is without influence.Supplement n-octacosanol can also reduce the content of triglycerides in blood plasma, improve the content of aliphatic acid, former
Because may be the activity for inhibiting heparin phosphohydrolase.It tests and also found, lipoprotein lipid enzyme activity in the greasiness tissue in kidney week
Property increase, the oxygenation efficiency of aliphatic acid increases in muscle, shows the lipid generation high in fat for affecting rat for adding n-octacosanol
It thanks.
It grows to even greater heights as the mankind return natural cry, using natural plant composition as cosmetic material causing
Cosmetic worker widely studies.Numerous studies show that some ingredients have acceleration lipid metabolism, beauty work(in natural plants
Effect, they to skin action temperature and, irritation is small, safe, has effects that can reach body shaping while beauty.Therefore,
Application of the natural plant composition in lipstick class cosmetics has very wide foreground.
Invention content
The purpose of the present invention is be directed to above-mentioned lipstick market there are the problem of, provide it is a kind of contribute to weight-reducing edible mouth
Red and preparation method thereof, using pure natural raw material, beeswax extract n-octacosanol is added, even if practical in pure plant extraction
Enter body afterwards, can also reach safe and harmless, lipid metabolism can also be helped speed up, reduces Foam cells and reach good body shaping
Effect, and add essential oil, proportion that natural moisture preserving ingredient accounts for it is larger, salubrious experience is brought to people.
The invention is realized by the following technical scheme：
A kind of preparation method for the edible lipstick for helping to lose weight, includes the following steps：
1) prepare the raw material of following weight proportion：
2) beeswax filter cloth package is placed in 80 DEG C of hot water and is melted, after the impurity in reject filter cloth, by the beeswax of melting
Cooling is stood to remove mechanical admixture, the 95v/v% ethyl alcohol of the weights such as the beeswax addition of mechanical admixture will be removed, 20min is boiled and take advantage of
Heat pours out ethanol solution, is repeated once, and solid is precipitated after cooling, filters, then washed twice with cold 95v/v% ethyl alcohol, removes
Cold ethyl alcohol dissolved matter will precipitate and merge to obtain refined beeswax with the ethyl alcohol insoluble matter of heat；
3) the refined beeswax that step obtains is weighed, is placed in reaction vessel, the 95v/ of 2-3 times of refined beeswax weight is added
The ethyl alcohol of v%, while the KOH for refining beeswax quality 10% is added, 90 DEG C of heating water baths, stirring, back flow reaction 4h, the reaction was complete
Stop stirring afterwards, be cooled to 70 DEG C, the extractant 120# gasoline of 2-3 times of refined beeswax weight is added, stirs 30min, then add
The water for entering 1-2 times of refined beeswax weight, stirs 10min, keeps the temperature stratification in 50 DEG C, liquid liquid phase separation takes organic extraction phase
It in 25 DEG C of cold crystallizations, filters, washing obtains crude glycol；
4) crude glycol for obtaining upper step uses volume ratio chloroform：N-hexane=3：1 mixed solution, with 1：15
Solid-to-liquid ratio carry out being recrystallized to give pure n-octacosanol at 35 DEG C；
5) it takes Brazil wax to be placed in the 95v/v% ethyl alcohol of 2-3 times of weight, is heated to 95-100 DEG C after sealing, and
Heating 20-40min is kept, solution is detached after Brazil wax dissolving；
6) filtered solution is placed in the appearance of opening by the solution for obtaining upper step using macromolecule dialysis membrane filtration
In device 5h is placed at 28-30 DEG C；
7) Brazil wax that upper step obtains is ground in grinder, candelila wax is carried out in grinder
Grinding；
8) olive oil, Sweet Almond Oil, sunflower seed oil, grape seed oil, breast wood is added in the material mixing for obtaining step 7)
Fruit oil, natural VE, and put into emulsification pot, it is heated to 80-85 DEG C, stirring；
9) after the substance of upper step is completely dissolved, red sorghum pigment is added, stirring obtains mixed material；
10) inject mold when the mixed material of upper step is cooled to 70-75 DEG C and be cooled to 2-10 DEG C, demoulding can at
Product.
Filter cloth described in step 2) of the present invention is the filter cloth of 200 mesh.
The step 6), be the solution for obtaining upper step use aperture for 2-5 microns macromolecule dialyse film mistake
Filter so that the poisonous metal chemical substance that Brazil wax mixes in production and processing is removed, and filtered solution is placed in
In open container 5h is placed at 28-30 DEG C.
Grinding described in step 7) is to grind 10-30min in the grinder that rotating speed is 4000-6000 turns/min.
Stirring described in step 8) and step 9), time 10-30min.
The invention further relates to the edible lipsticks for contributing to weight-reducing obtained using above-mentioned preparation method.
Compared with prior art, advantages of the present invention：
1, in alcohol saponification process, the selection of organic extractant is crucial, generally can all select benzene class, hexane, petroleum ether
Equal nonpolar solvents, and benzene kind of extractants is the most commonly used.The present invention by solvent property, solvent price, operation difficulty or ease, toxicity and
The combined factors such as product yield are screened and are considered, select 120# gasoline for optimum extraction solvent, the strong toxic solvents of benzene class is avoided to exist
To the injury of people in experiment.
2, during crystallization purifying, the single solvent of abandoning tradition uses combination solvent chloroform/n-hexane volume
Than 3：1 mode dissolving-recrystallization, improves the purity of n-octacosanol.
Specific implementation mode
With embodiment, the invention will be further described below, but the invention is not limited in these embodiments.
Embodiment 1：
A kind of preparation method for the edible lipstick for helping to lose weight, includes the following steps：
Step 1：300 parts of Brazil wax, 400 parts of candelila wax, 50 parts of olive oil, 80 parts of Sweet Almond Oil, sunflower seed
50 parts of oil, 50 parts of grape seed oil, 80 parts of shea butter, 100 parts of natural VE, 150 parts of beeswax, 400 parts of red sorghum pigment；
Step 2：The filter cloth package of 200 mesh of thick beeswax is placed in 80 DEG C of hot water and is melted, the impurity in reject filter cloth
Afterwards, the beeswax of melting is stood into cooling (removing mechanical admixture), appropriate 95% ethyl alcohol is added in the beeswax for removing mechanical admixture, is boiled
Boiling 20min pours out ethanol solution while hot, repeats primary.Solid is precipitated after cooling, filters, then washed twice with cold ethyl alcohol, removes
Cold ethyl alcohol dissolved matter (predominantly resin, stearic acid etc.) is removed, precipitation is merged into obtain refined beeswax with the ethyl alcohol insoluble matter of heat；
Step 3：It weighs 50g and refines beeswax, be placed in 500mL three-necked flasks, the ethyl alcohol that 125ml is 95% is added, simultaneously
6.79 grams of KOH are added, 90 DEG C of heating water baths, stirring, back flow reaction 4h, stopping stirring, is cooled to 70 DEG C or so after the reaction was complete,
150ml extractant 120# gasoline is added, stirs 30min, adds 75ml water, stirs 10min, in 50 DEG C of heat preservation standings point
Layer, liquid liquid phase separation take organic extraction mutually in 25 DEG C of cold crystallizations, to filter, and washing obtains crude glycol and (refines bee according to real income
Wax is produced according to the corresponding ratio of this step)；
Step 4：By crude glycol, chloroform/n-hexane (3 is selected：1), with 1：15 solid-to-liquid ratio is tied again at 35 DEG C
Crystalline substance obtains pure n-octacosanol；
Step 5：It takes Brazil wax to be placed in 95% ethyl alcohol, 95-100 DEG C is heated to after being sealed, and keep this
Temperature heats 20-40min, and solution is taken out after Brazil wax dissolving；
Step 6：By the solution taken out in step 5 using macromolecule dialysis membrane filtration so that Brazil wax is in life
The poisonous metal chemical substance mixed in production processing is removed, and filtered solution is placed in open container in 28-30 DEG C
Lower placement 5h；
Step 7：The Brazil wax obtained in step 6 is taken out in the grinder that rotating speed is 4000-6000 turns/min
It is ground 10-30min；
Step 8：Candelila wax is ground 10-30min in the grinder that rotating speed is 4000-6000 turns/min；
Step 9：It will be Step 4: olive oil, Sweet Almond Oil, sunflower seed oil, grape pip be added in seven, eight obtained substances
Oil, shea butter, natural VE are simultaneously put into emulsification pot, are heated at 80 DEG C -85 DEG C and are stirred 10-30min；
Step 10：Red sorghum pigment is added when the substance of step 9 is completely dissolved, stirs 10-30min, obtains mixed material；
Step 11：Inject mold when material to be mixed is cooled to 70 DEG C -75 DEG C and be cooled to 2-10 DEG C, demoulding can at
Product.
Embodiment 2：
A kind of preparation method for the edible lipstick for helping to lose weight, includes the following steps：
Step 1：400 parts of Brazil wax, 300 parts of candelila wax, 65 parts of olive oil, 65 parts of Sweet Almond Oil, sunflower seed
65 parts of oil, 65 parts of grape seed oil, 65 parts of shea butter, 120 parts of natural VE, 180 parts of beeswax, 500 parts of red sorghum pigment；
Step 2：The filter cloth package of 200 mesh of thick beeswax is placed in 80 DEG C of hot water and is melted, the impurity in reject filter cloth
Afterwards, the beeswax of melting is stood into cooling (removing mechanical admixture), appropriate 95% ethyl alcohol is added in the beeswax for removing mechanical admixture, is boiled
Boiling 20min pours out ethanol solution while hot, repeats once, solid is precipitated after cooling, filter, then washed twice with cold ethyl alcohol, remove
Cold ethyl alcohol dissolved matter (predominantly resin, stearic acid etc.) is removed, precipitation is merged into obtain refined beeswax with the ethyl alcohol insoluble matter of heat；
Step 3：It weighs 50g and refines beeswax, be placed in 500mL three-necked flasks, the ethyl alcohol that 125ml is 95% is added, simultaneously
Add 6.79 grams of KOH, 90 DEG C of heating water baths, stirring, back flow reaction 4h, stopping stirring, is cooled to 70 DEG C or so, adds after the reaction was complete
Enter 150ml extractant 120# gasoline, stir 30min, add 75ml water, stir 10min, stratification is kept the temperature in 50 DEG C,
Liquid liquid phase separation, takes organic extraction mutually in 25 DEG C of cold crystallizations, to filter, and washing obtains crude glycol and (refines beeswax root according to real income
It is produced according to the corresponding ratio of this step)；
Step 4：By crude glycol, chloroform/n-hexane (3 is selected：1), with 1：15 solid-to-liquid ratio is tied again at 35 DEG C
Crystalline substance obtains pure n-octacosanol；
Step 5：It takes Brazil wax to be placed in 95% ethyl alcohol, 95-100 DEG C is heated to after being sealed, and keep this
Temperature heats 20-40min, and solution is taken out after Brazil wax dissolving；
Step 6：By the solution taken out in step 5 using macromolecule dialysis membrane filtration so that Brazil wax is in life
The poisonous metal chemical substance mixed in production processing is removed, and filtered solution is placed in open container in 28-30 DEG C
Lower placement 5h；
Step 7：The Brazil wax obtained in step 6 is taken out in the grinder that rotating speed is 4000-6000 turns/min
It is ground 10-30min；
Step 8：Candelila wax is ground 10-30min in the grinder that rotating speed is 4000-6000 turns/min；
Step 9：It will be Step 4: olive oil, Sweet Almond Oil, sunflower seed oil, grape pip be added in seven, eight obtained substances
Oil, shea butter, natural VE are simultaneously put into emulsification pot, are heated at 80 DEG C -85 DEG C and are stirred 10-30min；
Step 10：Red sorghum pigment is added when the substance of step 9 is completely dissolved, stirs 10-30min, obtains mixed material；
Step 11：Inject mold when material to be mixed is cooled to 70 DEG C -75 DEG C and be cooled to 2-10 DEG C, demoulding can at
Product.
Embodiment 3：
A kind of preparation method for the edible lipstick for helping to lose weight, includes the following steps：
Step 1：400 parts of Brazil wax, 300 parts of candelila wax, 60 parts of olive oil, 60 parts of Sweet Almond Oil, sunflower seed
60 parts of oil, 60 parts of grape seed oil, 60 parts of shea butter, 120 parts of natural VE, 180 parts of beeswax, 500 parts of red sorghum pigment；
Step 2：The filter cloth package of 200 mesh of thick beeswax is placed in 80 DEG C of hot water and is melted, the impurity in reject filter cloth
Afterwards, the beeswax of melting is stood into cooling (removing mechanical admixture), appropriate 95% ethyl alcohol is added in the beeswax for removing mechanical admixture, is boiled
Boiling 20min pours out ethanol solution while hot, repeats primary.Solid is precipitated after cooling, filters, then washed twice with cold ethyl alcohol, removes
Remove cold ethyl alcohol dissolved matter (predominantly resin, stearic acid etc.).Precipitation is merged into obtain refined beeswax with the ethyl alcohol insoluble matter of heat；
Step 3：It weighs 50g and refines beeswax, be placed in 500mL three-necked flasks, the ethyl alcohol that 125ml is 95% is added, simultaneously
6.79 grams of KOH are added, 90 DEG C of heating water baths, stirring, back flow reaction 4h, stopping stirring, is cooled to 70 DEG C or so after the reaction was complete,
Add 150ml extractant 120# gasoline, stir 30min, add 75ml water, stir 10min, stratification is kept the temperature in 50 DEG C,
Liquid liquid phase separation, takes organic extraction mutually in 25 DEG C of cold crystallizations, to filter, and washing obtains crude glycol and (refines beeswax root according to real income
It is produced according to the corresponding ratio of this step)；
Step 4：By crude glycol, chloroform/n-hexane (3 is selected：1), with 1：15 solid-to-liquid ratio is tied again at 35 DEG C
Crystalline substance obtains pure n-octacosanol；
Step 5：It takes Brazil wax to be placed in 95% ethyl alcohol, 95-100 DEG C is heated to after being sealed, and keep this
Temperature heats 20-40min, and solution is taken out after Brazil wax dissolving；
Step 6：By the solution taken out in step 5 using macromolecule dialysis membrane filtration so that Brazil wax is in life
The poisonous metal chemical substance mixed in production processing is removed, and filtered solution is placed in open container in 28-30 DEG C
Lower placement 5h；
Step 7：The Brazil wax obtained in step 6 is taken out in the grinder that rotating speed is 4000-6000 turns/min
It is ground 10-30min；
Step 8：Candelila wax is ground 10-30min in the grinder that rotating speed is 4000-6000 turns/min；
Step 9：It will be Step 4: olive oil, Sweet Almond Oil, sunflower seed oil, grape pip be added in seven, eight obtained substances
Oil, shea butter, natural VE are simultaneously put into emulsification pot, are heated at 80 DEG C -85 DEG C and are stirred 10-30min；
Step 10：Red sorghum pigment is added when the substance of step 9 is completely dissolved, stirs 10-30min, obtains mixed material；
Step 11：Inject mold when material to be mixed is cooled to 70 DEG C -75 DEG C and be cooled to 2-10 DEG C, demoulding can at
Product.
Experimental example：
1, scratch test
After mouse is lost hair or feathers, lipstick is applied to mouse depilation position, mouse sign state, warp are observed every a hour
It observes, the performance of mouse sign is all gone well, and imitates the state that people uses lipstick, and early painting evening disappears, and is spaced 12 hours by smearing
Lipstick wash clean observes skin condition, and skin condition is all gone well, and allergic phenomena does not occur.It tests and sees repeatedly within such ten days
It examines, mouse sign is all gone well, and allergic phenomena does not occur for skin at smearing.
The aspiration participant of 50 people, smearing lipstick in 2 months by a definite date time are randomly selected, it is existing that lip does not generate allergy
As.
2, lipid metabolism in rats is tested
Experimental animal selects healthy adult male SD rat, and 30, weight controls room temperature 25 ± 1 between 110-130g
DEG C relative humidity 55 ± 15%, natural lighting.Ad lib and drinking-water replace feed and drinking water, replace bedding and padding weekly daily.
Adaptation starts to test after a week, nursing 10 weeks, weekly time recording the weight of animals and food ration.
SD rats are grouped at random by weight, every group 10, divide A, B cage, per 5, cage, picric acid dye marker.It is respectively
Blank control group, control group high in fat, lipstick group.It is as follows that each group feeds situation：
(1) blank control group：100% basal feed, drinking-water of freely ingesting；
(2) control group high in fat：High lipid food, drinking-water of freely ingesting；
(3) lipstick group：99% high lipid food, feeding are used lipstick before, drinking-water of freely ingesting.
Test it is feeds utilized be divided into basal feed and high lipid food, except basal feed used in blank control group is directly purchase
Finished product, remaining feed periodically make.High lipid food formula and lipstick group of formula be+10% yolk powder of 78.8% basal feed+
+ 0.2% cholate of+1% cholesterol of+5% lard of 5% sucrose.Making basal feed used in high lipid food and lipstick group feed is
Powdered, formula is identical with base particle feed.Above-mentioned formula Fodder making is periodically pressed weekly, and each group made is raised
Material through feeding after natural drying.
Sample collection and Indexs measure
During feeding, eyeball blood sampling is plucked after anhydrous ether is anaesthetized 4 weeks, 8 weekends.Wherein, A cage rats are won within 4 weeks
Right eye wins B cage rat right eyes for 8 weeks.It feeding for 10 weekends, each group SD Rat Fast 12h weigh, and measurement body is long, and eyeball takes blood,
Cervical dislocation is lethal, the separation heart, liver, spleen, lung, kidney；Internal organs are rinsed with physiological saline, filter paper is blotted, weighed, and is calculated internal organs and is referred to
Number.
The blood sample of acquisition is stood into 4h at room temperature, fully after solidification, 10min is centrifuged in 5000r/min, is taken after centrifugation
Layer serum, 4 DEG C stored refrigerated.300 μ L of serum are taken to measure rat blood serum total cholesterol (TC), highly dense with automatic clinical chemistry analyzer
Spend lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG) biochemical indicator.
Liver organization is observed
Rat when dissected, take a small pieces fresh liver tissue physiological saline clean, be put immediately into 4% paraformaldehyde it is molten
Fixed in liquid, tissue should not be too large to ensure that fixed liquid energy permeates rapidly hepatic tissue；Through it is a series of dehydration (80%, 90%,
95%, 100% ethyl alcohol), transparent (dimethylbenzene) processing after embedded with paraffin；Microtome, thickness are used after cooling and shaping
It it is 4 μm or so, in 45 DEG C of water surface tiles；After being sufficiently spread out, it is pasted into glass slide, 60 DEG C of pathological tissue drifts is placed in and dries instrument baking piece
20min sloughs the paraffin of tissue space.It is then dyed with Hematoxylin-eosin, neutral gum sealing, microscopically observation.
Statistical data processing
Experimental data is handled with SPSS16 statistical softwares, and comparison among groups are carried out with Student-Newman-Keuls methods
One-way analysis of variance (ANOVA) counts, and experimental data is indicated with mean value ± standard error (mean ± SE), P<0.05 is aobvious for difference
It writes.
Results and discussion
2.1 weight and food ration
The average weight and average daily food ration (g, x ± s) of 1 each group SD rats of table
Note：Compared with control group high in fat,**P<0.01,*P<0.05。
Each group SD rats are initial, 4 weeks, the average weight of 8 weeks and 10 weeks it is as shown in table 1.As seen from table, experiment initial (0
Week) when, the average weight of each group SD rats is without significant difference.After feeding 4 weeks, the weight of each group rat, which has, to be obviously increased,
But without significant difference between each group.After feeding 8 weeks, the average weight of control rats high in fat is increased compared with blank control group
4.65% (p=0.52), lipstick group rat average weight control group more high in fat increase 2.14% (p=0.73).It is 10 weekends, high
The average weight of fat control rats increases 11.44% (p compared with blank control group<0.01), this is mainly due to controls high in fat
Group feeding high lipid food, and caused by blank control group feeding normal diet；Compared with control group high in fat, the average weight of lipstick group
4.80% (p=0.40) is reduced, illustrates that n-octacosanol does not influence the average weight of rat.As seen from table, when initial
The average daily food ration of each group rat is respectively 108.20g, 112.00g and 121.30g, and there was no significant difference.Feed 4 weeks, 8 weeks and
After 10 weeks, the average daily food ration of control group and lipstick group rat high in fat shows that lipstick group does not interfere with rat without significant difference
Average daily food ration.
Influence of the 2.2 lipstick groups to Serum TC, TG, LDL-C, HDL-C
Cause blood fat to increase after rat oral gavage edible oil, shows as serum TG, TC and LDL-C and increase, Serum HDL-C drop
It is low.It is coated with after lipstick, serum TC, TG and LDL-C significantly reduce (P<0.01), and Serum HDL-C has no change (P>0.05).
Refer to following table：
Influence (x ± s) of 2 lipstick of table to rat
Note：Compared with the control group,#P<0.05,##P<0.01
Influence of the lipstick to rat weight and blood fat of this experiment discussion.It can be seen that lipstick group does not cause weight to change
Become.Lipstick group can be with substantial reduction in triglycerides and low-density lipoprotein.It also can reduce high-density lipoprotein simultaneously and serum is total
Cholesterol.
Claims (6)
1. a kind of preparation method for the edible lipstick for helping to lose weight, which is characterized in that include the following steps：
1) prepare the raw material of following weight proportion：
2) beeswax filter cloth package is placed in 80 DEG C of hot water and is melted, after the impurity in reject filter cloth, the beeswax of melting is stood
Cooling will remove the 95v/v% ethyl alcohol of the weights such as the beeswax addition of mechanical admixture, and boil 20min and incline while hot to remove mechanical admixture
Go out ethanol solution, be repeated once, solid is precipitated after cooling, filters, then washed twice with cold 95v/v% ethyl alcohol, remove cold second
Alcohol dissolved matter will precipitate and merge to obtain refined beeswax with the ethyl alcohol insoluble matter of heat；
3) the refined beeswax that step obtains is weighed, is placed in reaction vessel, the 95v/v% of 2-3 times of refined beeswax weight is added
Ethyl alcohol, while the KOH for refining beeswax quality 10% is added, 90 DEG C of heating water baths, stirring, back flow reaction 4h, after the reaction was complete
Stop stirring, be cooled to 70 DEG C, the extractant 120# gasoline of 2-3 times of refined beeswax weight is added, stirs 30min, adds
The water of 1-2 times of refined beeswax weight, stirs 10min, keeps the temperature stratification in 50 DEG C, liquid liquid phase separation, take organic extraction mutually in
25 DEG C of cold crystallizations filter, and washing obtains crude glycol；
4) crude glycol for obtaining upper step uses volume ratio chloroform：N-hexane=3：1 mixed solution, with 1：15 consolidate
Liquor ratio carries out being recrystallized to give pure n-octacosanol at 35 DEG C；
5) it takes Brazil wax to be placed in the 95v/v% ethyl alcohol of 2-3 times of weight, 95-100 DEG C is heated to after sealing, and keep
20-40min is heated, solution is detached after Brazil wax dissolving；
6) filtered solution is placed in open container by the solution for obtaining upper step using macromolecule dialysis membrane filtration
5h is placed at 28-30 DEG C；
7) Brazil wax that upper step obtains is ground in grinder, candelila wax is ground in grinder
Mill；
8) the wooden fruit of olive oil, Sweet Almond Oil, sunflower seed oil, grape seed oil, breast is added in the material mixing for obtaining step 7)
Oil, natural VE, and put into emulsification pot, it is heated to 80-85 DEG C, stirring；
9) after the substance of upper step is completely dissolved, red sorghum pigment is added, stirring obtains mixed material；
10) mold being injected when the mixed material of upper step is cooled to 70-75 DEG C and being cooled to 2-10 DEG C, demoulding can obtain finished product.
2. a kind of preparation method of edible lipstick for helping to lose weight according to claim 1, it is characterised in that：Step
2) filter cloth described in is the filter cloth of 200 mesh.
3. a kind of preparation method of edible lipstick for helping to lose weight according to claim 1, it is characterised in that：It is described
Step 6), be the solution for obtaining upper step use aperture for 2-5 microns macromolecule dialyse membrane filtration so that cohune
The poisonous metal chemical substance that palmitic acid wax mixes in production and processing is removed, by filtered solution be placed in open container in
5h is placed at 28-30 DEG C.
4. a kind of preparation method of edible lipstick for helping to lose weight according to claim 1, it is characterised in that：Step
7) grinding described in is to grind 10-30min in the grinder that rotating speed is 4000-6000 turns/min.
5. a kind of preparation method of edible lipstick for helping to lose weight according to claim 1, it is characterised in that：Step
8) and step 9) described in stirring, time 10-30min.
6. what claim 1-5 any one of them preparation methods obtained contributes to the edible lipstick of weight-reducing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236992A (en) * | 2019-07-31 | 2019-09-17 | 东晟源研究院(广州)有限公司 | The Recipe and preparation method of safety edible colorant lipstick |
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| CN102048659A (en) * | 2010-11-02 | 2011-05-11 | 深圳技师学院 | Edible lipstick and preparation method thereof |
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| CN105534754A (en) * | 2016-01-13 | 2016-05-04 | 佟佳倪 | Colorful edible lipstick |
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| CN102048659A (en) * | 2010-11-02 | 2011-05-11 | 深圳技师学院 | Edible lipstick and preparation method thereof |
| CN103330676A (en) * | 2013-07-23 | 2013-10-02 | 陆飞 | Manufacturing method of edible lipstick |
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| CN110236992A (en) * | 2019-07-31 | 2019-09-17 | 东晟源研究院(广州)有限公司 | The Recipe and preparation method of safety edible colorant lipstick |
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