CN108567899A - Chinese medicine composition, oral solution and preparation method thereof for treating diabetes - Google Patents
Chinese medicine composition, oral solution and preparation method thereof for treating diabetes Download PDFInfo
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Abstract
The invention discloses Chinese medicine composition, the oral solutions and preparation method thereof for treating diabetes, belong to technical field of Chinese medicine.The Chinese medicine composition for treating diabetes of the present invention, is grouped as by the group of following parts by weight：25 35 parts of Radix Astragali, 10 20 parts of radix pseudostellariae, 10 25 parts of sealwort, 10 25 parts of Poria cocos, 10 20 parts of Radix Rehmanniae, 20 25 parts of rhizoma anemarrhenae, 8 12 parts of Schisandra chinensis, 8 12 parts of radix scrophulariae, 8 12 parts of the fruit of Chinese wolfberry, 8 12 parts of black art powder.The Chinese medicine composition is when for treating mouse diabetes, it is good with hypoglycemic effect, it is without side-effects, the advantages that absorption that is not damaged to pancreas islet, inhibiting glucose and improvement fatty acid metabolism, PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM finds that the reparation and update of beta Cell of islet can be accelerated, the cell and its harmful substance for removing denaturation or apoptosis, promote the sensibility of insulin receptor.
Description
Technical field
The present invention relates to Chinese medicine composition, the oral solutions and preparation method thereof for treating diabetes, belong to traditional Chinese medicine skill
Art field.
Background technology
Diabetes are a kind of metabolic diseases caused by multi-pathogenesis characterized by chronic hyperglycemia, are due to insulin
Metabolic disease caused by hyposecretion or insulin action obstacle.Persistent high blood sugar and long-term metabolic disorder etc. can lead to whole body
Histoorgan, especially eye, kidney, the damage of angiocarpy and nervous system and its dysfunction and failure.With people's life water
Flat raising often eats high heat, high sugar, high-fat food in diet, cause the incidence of diabetes by
Year is soaring.
At present mainly by western medical treatment diabetes, still, there is also prodigious in terms for the treatment of diabetes for western medicine therapy
Shortcoming, wherein a most important performance is exactly that side effect is larger, if any medicine can influence water and electrolyte metabolism, influence
Blood fat, metabolism of blood glucose, some medicine long-term uses can also affect on sexual function etc..In addition, blood glucose fluctuation is larger during hypoglycemic, it is special
It is not early stage or senile diabetes, very sensitive to Western medicine antidiabetic drug, blood glucose may be fallen too low or even generating body after medication
Position property hypoglycemia, reduces dosage or secondary, and blood glucose may increase quickly again.
There is curative effect to stablize, have no adverse reaction for treatment of the Chinese medicine for diabetes and its complication, adjust
The advantages that organismic internal environment improves constitution, mitigates insulin-resistant states, adjust glycolipid metabolism, adjust immunity of organism, light
Type, middle patients with type Ⅰ DM preventing and controlling in occupy some superiority, the treatment especially for diabetic complication is significant in efficacy.But
Be current treatment diabetes the traditional Chinese medicine composition for treating course for the treatment of it is long, treat diabetes slowly effect.
Invention content
The purpose of the present invention is to provide a kind of Chinese medicine compositions for treating diabetes, and treatment diabetes are quick,
Short treating period.
The present invention also provides a kind of oral solutions for treating diabetes.
The present invention also provides the preparation methods of above-mentioned oral solution.
To achieve the goals above, the technical solution adopted in the present invention is：
Chinese medicine composition for treating diabetes is grouped as by the group of following parts by weight：25-35 parts of Radix Astragali, radix pseudostellariae
10-20 parts, 10-25 parts of sealwort, 10-25 parts of Poria cocos, 10-20 parts of Radix Rehmanniae, 20-25 parts of rhizoma anemarrhenae, 8-12 parts of Schisandra chinensis, radix scrophulariae 8-12
Part, 8-12 parts of the fruit of Chinese wolfberry, 8-12 parts of black art powder.
Preferably, the Chinese medicine composition for treating diabetes is grouped as by the group of following parts by weight：30 parts of Radix Astragali, too
20 parts of son ginseng, 15 parts of sealwort, 15 parts of Poria cocos, 20 parts of Radix Rehmanniae, 20 parts of rhizoma anemarrhenae, 10 parts of Schisandra chinensis, 10 parts of radix scrophulariae, 10 parts of the fruit of Chinese wolfberry,
10 parts of black art powder.
The function of Radix Astragali is tonifying Qi and lifting yang in the Chinese medicine composition of the present invention, and tonifying lung consolidates table, inducing diuresis for removing edema, expelling pus and promoting granulation,
It is the key medicine of tonifying Qi qi-restoratives.It is usually used in treating spleen-lung Qi deficiency on tcm clinical practice, yang-energy sink or insufficiency of vital energy and blood or blood deficiency and depleted fluid
Deng card.Radix Astragali master (I, II, III, IV) containing astragalin, the ingredients such as daucosterol and Sayasaponin Ⅰ.Active ingredient Radix Astragali in Radix Astragali
Polysaccharide (APS), can reduce glucose load, have and adjust blood glucose, protect cardiovascular system, improve the work of myocardial ischemic injury
With the cumarin isoreactivity ingredient that Radix Astragali contains also has reduction blood glucose effect.
Contain radix pseudostellariae in the Chinese medicine composition of the present invention, Pseudostellaria Polysaccharide can reduce diabetic mice blood glucose, increase body
Weight increases hepatic glycogen content.
Sealwort in the Chinese medicine composition of the present invention is mild-natured, sweet in flavor, returns spleen, lung, kidney channel.Sealwort contain lymphatic temperament, starch,
The ingredients such as carbohydrate, a variety of amino acid, multivitamin and alkaloid have enhancing immune function, anti-aging, resist oxygen lack, anti-tired
The effects that labor, antibacterial, enhancing metabolism, and can blood pressure lowering, hypoglycemic, reduction serum cholesterol and triacylglycerol.
Poria cocos sclerotium in the Chinese medicine composition of the present invention accounts for about dry weight 93% and triterpene compound containing β-pachyman
Pachymic acid, pachymic acid, 3 beta-hydroxy wool steroid trienic acids have diuresis, antibacterial, antineoplastic action, while having drop blood
The effect of sugar.
The polysaccharide in Radix Rehmanniae in the Chinese medicine composition of the present invention can treat diabetes, reduce blood glucose.
Rhizoma anemarrhenae in the Chinese medicine composition of the present invention can also reduce blood glucose.
Schisandra chinensis in the Chinese medicine composition of the present invention can improve the combined immune power of body, be used for auxiliary treatment glycosuria
Disease.
Radix scrophulariae in the Chinese medicine composition of the present invention can improve the combined immune power of body, be used for auxiliary treatment glycosuria
Disease.
The fruit of Chinese wolfberry in the Chinese medicine composition of the present invention can improve the combined immune power of body, be used for auxiliary treatment glycosuria
Disease.
Black art powder in the Chinese medicine composition of the present invention can improve the combined immune power of body, be used for auxiliary treatment glycosuria
Disease.
The Chinese medicine composition of the present invention is guidance with theory of traditional Chinese medical science and modern pharmacology, and sorting is simple, treats mouse diabetes
Significant effect, the healing period is short, solves the deficiency in the presence for the treatment of Chinese medicine for treating diabetes at present.The Chinese traditional medicine composition of the present invention simultaneously
Object has stimulation islet β cell insulin, the sensibility repaired islet function, increase insulin receptor, inhibits glucose
Absorption, improve the effects that fatty acid metabolism, and it is excellent with stimulating that small, toxicity is low, reparation is fast, is not likely to produce drug resistance etc.
Point.
Oral solution for treating diabetes is made of the Chinese medicine material of following parts by weight：25-35 parts of Radix Astragali, radix pseudostellariae
10-20 parts, 10-25 parts of sealwort, 10-25 parts of Poria cocos, 10-20 parts of Radix Rehmanniae, 20-25 parts of rhizoma anemarrhenae, 8-12 parts of Schisandra chinensis, radix scrophulariae 8-12
Part, 8-12 parts of the fruit of Chinese wolfberry, 8-12 parts of black art powder.
The oral solution of the present invention has stimulation islet β cell insulin, repairs islet function, increases insulin receptor
Sensibility, inhibit glucose absorption, improve fatty acid metabolism the effects that.When for treating mouse diabetes, there is hypoglycemic
The advantages that effect is good, without side-effects, absorption that is not damaged to pancreas islet, inhibiting glucose and improvement fatty acid metabolism, pathomorphism
It learns observation and finds that the invention can accelerate the reparation and update of beta Cell of islet, remove the cell and its harmful substance of denaturation or apoptosis,
Promote the sensibility of insulin receptor.
The above-mentioned preparation method for treating the oral solution of diabetes includes the following steps：
1) it takes the Chinese medicine material of formula ratio to be mixed with water, impregnates, decocts, leach cooking liquid is sieved to obtain first-time filtrate；
2) dregs of a decoction that are obtained in step 1) are added water and decoct, and leach cooking liquid is sieved to obtain secondary filtrate；
3) dregs of a decoction that are obtained in step 2) are added water and decoct, and leach cooking liquid is sieved to obtain filtrate three times；
4) merge each secondary filtrate to get.
Preferably, the time impregnated in step 1) is 30-60min.
Preferably, it is that high heat decoction is extremely boiled to be decocted described in step 1), is then cooked by slow fire and keeps slightly boiling 1-1.5h.
Preferably, it is that high heat decoction is extremely boiled to be decocted described in step 2), is then cooked by slow fire and keeps slightly boiling 30-50min.
Preferably, it is that high heat decoction is extremely boiled to be decocted described in step 3), is then cooked by slow fire and keeps slightly boiling 20-40min.
The slightly boiling refers to boiling.
The sieving was the sieve of 200 mesh or more.
Preferably, the sieving was the sieve of 200 mesh.
Preferably, the above-mentioned preparation method for treating the oral solution of diabetes, includes the following steps：
1) it takes the Chinese medicine material of formula ratio and water that 4-8 times is measured mixes, impregnate, decoct, leach cooking liquid is sieved to obtain first-time filtrate；
2) dregs of a decoction in step 1) are added 3-7 times of Chinese medicine material and measure water decoction, and leach cooking liquid is sieved to obtain secondary filtrate；
3) dregs of a decoction in step 2) are added 3-5 times of Chinese medicine material and measure water decoction, and leach cooking liquid is sieved to obtain filtrate three times；
4) merge each secondary filtrate, be concentrated into Chinese medicine material it is 4-6 times heavy to get.
The preparation method of the oral solution for treating diabetes of the present invention, preparation process is simple, suitable for mass production.
Description of the drawings
Mouse diabetic model group pancreatic tissue is sliced micrograph in Fig. 1 test examples；
Blank group pancreatic tissue is sliced micrograph in Fig. 2 test examples；
Experimental group pancreatic tissue is sliced micrograph in Fig. 3 test examples；
Control group pancreatic tissue is sliced micrograph in Fig. 4 test examples.
Specific implementation mode
With reference to specific embodiment, the present invention is described in further detail.
Embodiment 1
Chinese medicine composition in the present embodiment for treating diabetes, is grouped as by the group of following parts by weight：30 parts of Radix Astragali,
20 parts of radix pseudostellariae, 15 parts of sealwort, 15 parts of Poria cocos, 20 parts of Radix Rehmanniae, 20 parts of rhizoma anemarrhenae, 10 parts of Schisandra chinensis, 10 parts of radix scrophulariae, the fruit of Chinese wolfberry 10
Part, 10 parts of black art powder.
Oral solution in the present embodiment for treating diabetes, is made of the Chinese medicine material of following parts by weight：Radix Astragali 30g,
Radix pseudostellariae 20g, sealwort 15g, Poria cocos 15g, Radix Rehmanniae 20g, rhizoma anemarrhenae 20g, Schisandra chinensis 10g, radix scrophulariae 10g, fruit of Chinese wolfberry 10g, black art powder
10g。
The above-mentioned preparation method for treating the oral solution of diabetes in the present embodiment, includes the following steps：
1) it takes the water that the Chinese medicine material of formula ratio is measured with 6 times to mix, impregnates 30min, high heat decoction is extremely boiled, then slow boiling
It decocts and keeps slightly boiling 1h, leach cooking liquid uses 200 mesh screens, obtains first-time filtrate and the dregs of a decoction；
2) 5 times of amount water of Chinese medicine material are added in the dregs of a decoction of step 1), then high heat decoction is cooked by slow fire holding slightly boiling to boiling
40min, leach cooking liquid are filtered using 200 mesh screens, obtain secondary filtrate and the dregs of a decoction；
3) 4 times of amount water of Chinese medicine material are added in the dregs of a decoction of step 2), then high heat decoction is cooked by slow fire holding slightly boiling to boiling
30min, leach cooking liquid are filtered using 200 mesh screens, obtain filtrate three times；
4) merge each secondary filtrate, be concentrated into 800mL to get.
Embodiment 2
Chinese medicine composition in the present embodiment for treating diabetes, is grouped as by the group of following parts by weight：25 parts of Radix Astragali,
10 parts of radix pseudostellariae, 10 parts of sealwort, 10 parts of Poria cocos, 10 parts of Radix Rehmanniae, 25 parts of rhizoma anemarrhenae, 8 parts of Schisandra chinensis, 8 parts of radix scrophulariae, 8 parts of the fruit of Chinese wolfberry, crow
8 parts of art powder.
Oral solution in the present embodiment for treating diabetes, is made of the Chinese medicine of following parts by weight：25 parts of Radix Astragali, crown prince
10 parts of ginseng, 10 parts of sealwort, 10 parts of Poria cocos, 10 parts of Radix Rehmanniae, 25 parts of rhizoma anemarrhenae, 8 parts of Schisandra chinensis, 8 parts of radix scrophulariae, 8 parts of the fruit of Chinese wolfberry, black art powder
8 parts.
The above-mentioned preparation method for treating the oral solution of diabetes in the present embodiment, includes the following steps：
1) it takes the water that the Chinese medicine material of formula ratio is measured with 4 times to mix, impregnates 45min, high heat decoction is extremely boiled, then slow boiling
It decocts and keeps slightly boiling 1.5h, leach cooking liquid uses 200 mesh screens, obtains first-time filtrate and the dregs of a decoction；
2) 3 times of amount water of Chinese medicine material are added in the dregs of a decoction of step 1), then high heat decoction is cooked by slow fire holding slightly boiling to boiling
30min, leach cooking liquid are filtered using 200 mesh screens, obtain secondary filtrate and the dregs of a decoction；
3) 3 times of amount water of Chinese medicine material are added in the dregs of a decoction of step 2), then high heat decoction is cooked by slow fire holding slightly boiling to boiling
20min, leach cooking liquid are filtered using 200 mesh screens, obtain filtrate three times；
4) merge each secondary filtrate, be concentrated into 4 times of weights of Chinese medicine material to get.
Embodiment 3
Chinese medicine composition in the present embodiment for treating diabetes, is grouped as by the group of following parts by weight：35 parts of Radix Astragali,
15 parts of radix pseudostellariae, 25 parts of sealwort, 25 parts of Poria cocos, 15 parts of Radix Rehmanniae, 23 parts of rhizoma anemarrhenae, 12 parts of Schisandra chinensis, 12 parts of radix scrophulariae, the fruit of Chinese wolfberry 12
Part, 12 parts of black art powder.
Oral solution in the present embodiment for treating diabetes, is made of the Chinese medicine of following parts by weight：35 parts of Radix Astragali, crown prince
15 parts of ginseng, 25 parts of sealwort, 25 parts of Poria cocos, 15 parts of Radix Rehmanniae, 23 parts of rhizoma anemarrhenae, 12 parts of Schisandra chinensis, 12 parts of radix scrophulariae, 12 parts of the fruit of Chinese wolfberry, crow
12 parts of art powder.
The above-mentioned preparation method for treating the oral solution of diabetes in the present embodiment, includes the following steps：
1) it takes the water that the Chinese medicine material of formula ratio is measured with 8 times to mix, impregnates 60min, high heat decoction is extremely boiled, then slow boiling
It decocts and keeps slightly boiling 1h, leach cooking liquid uses 200 mesh screens, obtains first-time filtrate and the dregs of a decoction；
2) 7 times of amount water of Chinese medicine material are added in the dregs of a decoction of step 1), then high heat decoction is cooked by slow fire holding slightly boiling to boiling
50min, leach cooking liquid are filtered using 200 mesh screens, obtain secondary filtrate and the dregs of a decoction；
3) 5 times of amount water of Chinese medicine material are added in the dregs of a decoction of step 2), then high heat decoction is cooked by slow fire holding slightly boiling to boiling
40min, leach cooking liquid are filtered using 200 mesh screens, obtain filtrate three times；
4) merge each secondary filtrate, be concentrated into 6 times of weights of Chinese medicine material to get.
Test example
One, experimental animal is grouped
Take Balb/c mouse 80, weight (180~250g) laboratory rearing after a week, be randomly divided into 3 groups, cage divided to raise
It supports.18~22 DEG C of animal house temperature, relative humidity 55%~75%, natural lighting are fed with solid balanced feed, free water.
Two, Model of diabetic rat is established
It weighs citric acid 1.05g and the A liquid for being made into a concentration of 0.05mol/L is added in distilled water 100ml；Weigh citric acid three
The B liquid for being made into a concentration of 0.05mol/L is added in distilled water 100ml in sodium 1.47g；A, B liquid are pressed 1 using preceding:0.94 mixing, i.e.,
At the citric acid-sodium citrate buffer solution of pH=4.6.Alloxan (Alloxan), dosage 200mg/ are weighed according to mouse weight
Kg is set in sterile penicillin bottle, will newly be matched in citric acid-sodium citrate buffer solution injection Alloxan pulvis before, and be rocked molten
Solution is made into required a concentration of Alloxan solution, the alloxan (matching while using) of intraperitoneal injection.Add in 3h drinking-water after injection
Enter 25% glucose 1ml/100g；It is injected intraperitoneally again afterwards for 24 hours, 72 hours tail vein bloods of injection drug survey blood sugar concentration.Blood glucose
Concentration is judged as modeling successfully for continuous 2 days more than 11mmol/L.Randomly choose 20 diabetic rat models as model group, at random
Non- modeling mouse 20 is chosen, as blank group (Vehicle), this group of mouse conventinal breeding, daily gavage physiological saline (10mL/kg/
Day) 1 time.
Three, medication
Model mouse 40 is taken, is randomly divided into experimental group and control group, every group 20.Experimental group uses the oral of embodiment 1
The daily gavage of liquid, dosage 10mL/kg/ days are administered each 1 time, successive administration 30d sooner or later, single cage raising.Control group do not give to
Medicine is handled, the blood glucose value variation of 2h after monitoring mouse weight and the preceding 2h of feeding in experimentation daily and searching for food.Experimental group with compare
Group mouse change of blood sugar and experimental group weight are as shown in table 1.
1 experimental group of table and control group mouse blood glucose and weight test value
From table 1 it follows that experimental group is compared compared with control group, blood-sugar content is decreased obviously, the oral solution pair of embodiment 1
There is significant improvement result in mouse diabetes.The oral solution pair is illustrated without significant change to mouse weight before and after experimental group experiment
It is without side-effects in mouse.
Four, pancreatic tissue pathological observation
Behind the 7th day, the 14th day, the 21st day and 30 days medication 1h, 5 mouse cervical dislocations is taken to put to death every time, dissection is taken out
Pancreas is laid on filter paper, is subsequently placed in the formalin fixer of Fresh, and routinely paraffin wax flaking method is taken off
Water is transparent, paraffin embedding, slice, and slice thickness is 4~6 μm, and hematoxylin eosin staining (HE dyeing), micro- sem observation simultaneously shines
Phase.
Five, test result
It is as shown in Figure 1 that mouse diabetic model group pancreatic tissue is sliced microscopic findings：Pancreas interstitial as can be seen from Figure 1
Congestion and edema, small interlobar fissure is broadening, and large-scale acinus structure is destroyed, interstitial adipose tissue necrosis, a large amount of cell infiltrations, gland
Steep swelling.It is as shown in Figure 2 that blank group pancreatic tissue is sliced microscopic findings：Acinus size and form differs as can be seen from Figure 2,
Structural integrity is made of one layer of cone-shaped acinar cells, and no focal acinus withers, no inflammation cellular infiltration around blood vessel.Experimental group
Pancreatic tissue slice microscopic findings are as shown in Figure 3 after continuous gavage Chinese medicine 30d：Pancreatic tissue oedema as can be seen from Figure 3
Mitigate, with a small amount of cell infiltration, acinus and conduit are normal, and pancreatic tissue dyeing shows that islet cells volume first increases
After reduce, alleviate inflammatory reaction and the pathological change of pancreatic tissue.Control group pancreatic tissue is sliced microscopic findings such as Fig. 4
It is shown：From fig. 4, it can be seen that visible many places focal lesion in acinar tissue, shows as acinus atrophy, volume-diminished, dyeing
Deepen, karyopycnosis, acinar cells arrangement is loose, there is lymphocyte and monocyte infiltration.
The experimental results showed that：Without significant change, the oral solution of embodiment 1 can significantly reduce the front and back mouse weight of experimental group experiment
Fasting blood-glucose, mouse diabetic model group more visible pancreas interstitial congestion and edema compared with blank group, small interlobar fissure is broadening, on a large scale
Acinus structure destroy, interstitial adipose tissue necrosis, a large amount of cell infiltrations, acinus swelling.Experimental group after medication and control
Group compares, and experimental group pancreatic tissue oedema mitigates, and with a small amount of cell infiltration, acinus and conduit are normal, pancreas group
It knits dyeing and shows that islet cells volume first increases and reduces afterwards, alleviate inflammatory reaction and the pathological change of pancreatic tissue.Illustrate this
Oral solution has certain protective effect to mouse diabetes model pancreatic tissue, and it is thin to significantly improve blood glucose level, protection pancreas islet β
Born of the same parents, this provides a kind of new treatment means for the treatment of diabetes.
Claims (10)
1. the Chinese medicine composition for treating diabetes, it is characterised in that：It is grouped as by the group of following parts by weight：Radix Astragali 25-35
Part, 10-20 parts of radix pseudostellariae, 10-25 parts of sealwort, 10-25 parts of Poria cocos, 10-20 parts of Radix Rehmanniae, 20-25 parts of rhizoma anemarrhenae, Schisandra chinensis 8-12
Part, 8-12 parts of radix scrophulariae, 8-12 parts of the fruit of Chinese wolfberry, 8-12 parts of black art powder.
2. the Chinese medicine composition according to claim 1 for treating diabetes, it is characterised in that：By following parts by weight
Group is grouped as：30 parts of Radix Astragali, 20 parts of radix pseudostellariae, 15 parts of sealwort, 15 parts of Poria cocos, 20 parts of Radix Rehmanniae, 20 parts of rhizoma anemarrhenae, 10 parts of Schisandra chinensis,
10 parts of radix scrophulariae, 10 parts of the fruit of Chinese wolfberry, 10 parts of black art powder.
3. the oral solution for treating diabetes, it is characterised in that：It is made of the Chinese medicine material of following parts by weight：Radix Astragali 25-35
Part, 10-20 parts of radix pseudostellariae, 10-25 parts of sealwort, 10-25 parts of Poria cocos, 10-20 parts of Radix Rehmanniae, 20-25 parts of rhizoma anemarrhenae, Schisandra chinensis 8-12
Part, 8-12 parts of radix scrophulariae, 8-12 parts of the fruit of Chinese wolfberry, 8-12 parts of black art powder.
4. the preparation method according to claim 3 for treating the oral solution of diabetes, it is characterised in that：Including as follows
Step：
1) it takes the Chinese medicine material of formula ratio to be mixed with water, impregnates, decocts, leach cooking liquid is sieved to obtain first-time filtrate；
2) dregs of a decoction that are obtained in step 1) are added water and decoct, and leach cooking liquid is sieved to obtain secondary filtrate；
3) dregs of a decoction that are obtained in step 2) are added water and decoct, and leach cooking liquid is sieved to obtain filtrate three times；
4) merge each secondary filtrate to get.
5. the preparation method according to claim 4 for treating the oral solution of diabetes, it is characterised in that：In step 1)
The time of immersion is 30-60min.
6. the preparation method according to claim 4 for treating the oral solution of diabetes, it is characterised in that：In step 1)
Described decoct is that high heat decoction is extremely boiled, and is then cooked by slow fire and keeps slightly boiling 1-1.5h.
7. the preparation method according to claim 4 for treating the oral solution of diabetes, it is characterised in that：In step 2)
Described decoct is that high heat decoction is extremely boiled, and is then cooked by slow fire and keeps slightly boiling 30-50min.
8. the preparation method according to claim 4 for treating the oral solution of diabetes, it is characterised in that：In step 3)
Described decoct is that high heat decoction is extremely boiled, and is then cooked by slow fire and keeps slightly boiling 20-40min.
9. the preparation method according to claim 4 for treating the oral solution of diabetes, it is characterised in that：The sieving
To cross the sieve of 200 mesh or more.
10. the preparation method according to claim 4 for treating the oral solution of diabetes, it is characterised in that：Including such as
Lower step：
1) it takes the Chinese medicine material of formula ratio and water that 4-8 times is measured mixes, impregnate, decoct, leach cooking liquid is sieved to obtain first-time filtrate；
2) dregs of a decoction in step 1) are added 3-7 times of Chinese medicine material and measure water decoction, and leach cooking liquid is sieved to obtain secondary filtrate；
3) dregs of a decoction in step 2) are added 3-5 times of Chinese medicine material and measure water decoction, and leach cooking liquid is sieved to obtain filtrate three times；
4) merge each secondary filtrate, be concentrated into Chinese medicine material it is 4-6 times heavy to get.
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Citations (3)
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|---|---|---|---|---|
| CN1833706A (en) * | 2005-03-17 | 2006-09-20 | 黄菊 | Medicine for treating diabets onellitus and prepn. thereof |
| CN101120992A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines rehmanniae radix, ophiopogon Japonicus, and radix scrophulariae for heat-clearing dryness-moistruizing and treating diabetes |
| CN105394763A (en) * | 2015-12-17 | 2016-03-16 | 劲膳美生物科技股份有限公司 | Pregnant-woman diabetes total-nutrient formula food |
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| CN1833706A (en) * | 2005-03-17 | 2006-09-20 | 黄菊 | Medicine for treating diabets onellitus and prepn. thereof |
| CN101120992A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines rehmanniae radix, ophiopogon Japonicus, and radix scrophulariae for heat-clearing dryness-moistruizing and treating diabetes |
| CN105394763A (en) * | 2015-12-17 | 2016-03-16 | 劲膳美生物科技股份有限公司 | Pregnant-woman diabetes total-nutrient formula food |
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Application publication date: 20180925 |