CN108567825A - The fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice - Google Patents
The fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice Download PDFInfo
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- CN108567825A CN108567825A CN201810733236.4A CN201810733236A CN108567825A CN 108567825 A CN108567825 A CN 108567825A CN 201810733236 A CN201810733236 A CN 201810733236A CN 108567825 A CN108567825 A CN 108567825A
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- China
- Prior art keywords
- materical crude
- fleece
- crude slice
- medicine materical
- fresh
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- 239000003814 drug Substances 0.000 title claims abstract description 26
- 240000001341 Reynoutria japonica Species 0.000 title claims abstract description 14
- 235000018167 Reynoutria japonica Nutrition 0.000 title claims abstract description 14
- 239000000843 powder Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract 2
- FFWOKTFYGVYKIR-UHFFFAOYSA-N physcion Chemical compound C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1O FFWOKTFYGVYKIR-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- CQNVSNFEXPKHGW-UHFFFAOYSA-N 2-hydroxychrysophanol Chemical compound O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(C)C(O)=C2O CQNVSNFEXPKHGW-UHFFFAOYSA-N 0.000 claims description 3
- 244000291564 Allium cepa Species 0.000 claims description 3
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims description 3
- 239000010282 Emodin Substances 0.000 claims description 3
- 241001289529 Fallopia multiflora Species 0.000 claims description 3
- UGNZSMZSJYOGNX-UHFFFAOYSA-N Isoviocristine Natural products O=C1C=C(C)C(=O)C2=CC3=CC(OC)=CC(O)=C3C(O)=C21 UGNZSMZSJYOGNX-UHFFFAOYSA-N 0.000 claims description 3
- WLXGUTUUWXVZNM-UHFFFAOYSA-N anthraglycoside A Natural products C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1OC1OC(CO)C(O)C(O)C1O WLXGUTUUWXVZNM-UHFFFAOYSA-N 0.000 claims description 3
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 claims description 3
- 150000004053 quinones Chemical class 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 244000141353 Prunus domestica Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that：The fleece-flower root harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution is freeze-dried after being condensed into clear cream, then is vacuum-packed after crushing, being sieved.The water content of powder decoction pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical field, the manufacture field for especially belonging to fleece-flower root medicine materical crude slice is fallen.
Background technology
The Chinese medicine fleece-flower root is polygonum multiflorum thunbPolygonum multijiorum Thunb. dried root, has
Removing toxic substances, disappear carbuncle, preventing malaria, the effect of relaxing bowel.This product is mainly used for sore carbuncle, and scrofula, rubella itch, chronic malaria body void, intestinal dryness is just
Secret treatment is a herb common on tcm clinical practice.The processing method of traditional fleece-flower root is：When autumn, two season of winter leaf are withered
Excavation, prunes both ends, cleans, it is a it is big be cut into block, it is dry, be packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, does
Dry, packaging.Such medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, store and transport
It is of high cost.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Cause
This, develop a kind of stable quality is reliable, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action novel
Fleece-flower root medicine materical crude slice, it is imperative.Existing market fleece-flower root medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentration
Two kinds of forms of granule pieces, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultra micro
Medicine materical crude slice cannot solve the problems, such as that medicinal material pollutes；Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that：In the fleece-flower root
After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~
The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering,
Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.15 ~ 1.25 clear cream.It is cold in -20 ~ -40 DEG C of vacuum after gained clear cream is freezed 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators
It is lyophilized dry.Lyophilized products be dried under vacuum to again at 60 ~ 80 DEG C water content be less than 10%, crush, cross 60 mesh sieve, vacuum packaging to get at
Product.The finished product medicine materical crude slice Onion quinones of He containing Jie are with rheum emodin（C15H10O5）And Physcion（C16H12O5）Total amount meter, must not be less than
0.20%.The clinical general usage amount of this medicine materical crude slice is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, powder, capsule
In agent and tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.
The present invention solve traditional fleece-flower root medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested,
The shortcomings such as the poor, unstable quality of hygiene condition, due to being to take advantage of fresh extraction, quality is than ultramicro grinding medicine materical crude slice and concentrated granular
Medicine materical crude slice is more preferable.
Specific embodiment
It after polygonum multiflorum medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours certainly
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction
Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.20 to be concentrated into relative density
Clear cream.By the clear cream of gained after -80 DEG C are freezed 12 hours, in -40 DEG C of vacuum freeze dryings.Dried object is dry with 60 DEG C of vacuum again
It is dry to water content be 8%, crush, cross 60 mesh sieve, be vacuum-packed to get finished product.The finished product medicine materical crude slice Onion quinones of He containing Jie are with rheum emodin
（C15H10O5）And Physcion（C16H12O5）Total amount meter, be 0.30%.
Claims (2)
1. a kind of fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that：It is net in time after polygonum multiflorum medicinal material harvesting
Choosing, removal impurity and the dis-medicinal part such as silt, keeps medicinal material surface wettability, cleans and cuts in taking advantage of using fresh herb tap water in 24 hours
At the piece of 2 ~ 5mm thickness, the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight is added, impregnate and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes
Juice；The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects medicine
Juice；Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.15 ~ 1.25 to be concentrated into relative density
Clear cream；After gained clear cream freezes 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, in -20 ~ -40 DEG C of vacuum freeze dryings；Freeze-drying
Object is dried under vacuum to water content at 60 ~ 80 DEG C and is less than 12% again, crushes, and crosses 60 mesh sieve, is vacuum-packed to get finished product；Finished product medicine materical crude slice
The Onion quinones of He containing Jie are with rheum emodin（C15H10O5）And Physcion（C16H12O5）Total amount meter, must not be less than 0.20%.
2. the fleece-flower root according to claim 1 is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that：Clinic generally makes
Dosage is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733236.4A CN108567825A (en) | 2018-07-06 | 2018-07-06 | The fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733236.4A CN108567825A (en) | 2018-07-06 | 2018-07-06 | The fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108567825A true CN108567825A (en) | 2018-09-25 |
Family
ID=63573797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733236.4A Withdrawn CN108567825A (en) | 2018-07-06 | 2018-07-06 | The fleece-flower root is fresh to carry freeze-dried powder medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108567825A (en) |
-
2018
- 2018-07-06 CN CN201810733236.4A patent/CN108567825A/en not_active Withdrawn
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180925 |