CN108552535A - 钙软胶囊及制备方法 - Google Patents
钙软胶囊及制备方法 Download PDFInfo
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- CN108552535A CN108552535A CN201810308101.3A CN201810308101A CN108552535A CN 108552535 A CN108552535 A CN 108552535A CN 201810308101 A CN201810308101 A CN 201810308101A CN 108552535 A CN108552535 A CN 108552535A
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- calcium
- gelatin
- tricalcium phosphate
- beeswax
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种钙软胶囊及制备方法，其中，该钙软胶囊包括胶皮囊，及在胶皮囊内封装的钙物料液，所述的钙物料液包括磷酸三钙30％、柠檬酸钙10％、L‑乳酸钙3％、核桃油56.6％、蜂蜡0.39％、甜菊糖苷0.01％。胶皮囊包括60％的明胶、26％的甘油、3％的二氧化钛和11％的纯化水。本发明具有提供多种钙源且钙含量高，及胃肠道刺激较低和口感好的效果。
Description
技术领域
本发明涉及生物与新医药领域，特别涉及一种钙软胶囊及制备方法。
背景技术
我们知道，钙是维持人体健康所必需的一种元素，也是人体内含量最多的无机元素，其中99％的钙与磷结合集中在骨骼和牙齿中，另外一小部分钙存在于机体的软组织和血液中，在机体各种生理学和生物化学过程中起着重要作用。从膳食结构分析，中国人属于缺钙人群，原因在于：我国是以植物性食物为主的膳食结构，而谷物中的植酸、某些蔬菜如菠菜、苋菜、竹笋等含草酸较多，植酸、草酸能与钙结合成不溶性的钙盐，降低钙的吸收率；膳食纤维中的醛糖酸残基与钙结合，可干扰钙的吸收；此外，食物中钙磷的比例失调，都会影响人体对钙的吸收而导致缺钙，上述原因导致从膳食中获得的钙普遍不足。调查显示：在城市中51％的男性和60％的妇女钙的摄入量没有达到所需要量的一半，达到标准的还不到10％；城市少年儿童中有72％、79％的人钙的摄入量不到标准的一半，农村的儿童少年钙的摄入量更低。临床研究证实，缺钙容易导致和引发骨骼畸形、骨质疏松、肌肉痉挛、原发性高血压等症状，幼儿缺钙易患佝偻病，生长不良。相比之下，口服补钙品是一种有效的补钙方法。目前市场上的产品主要以化学药品和中成药较多，而且以无机钙较多，含钙量较低，且存在着副作用，如碳酸钙对胃肠道刺激大，常会出现胃肠道不适的等现象，并且不易被吸收利用。因此，研究开发一种钙磷平衡、配比科学、含钙量高，生物利用率高的补钙保健食品具有重要意义。目前，市面上的钙制剂来源大多以无机钙为主。由于无机钙的钙制剂存在溶解度低，对胃肠道刺激大的缺点，不适合幼儿食用的缺陷；只有少数以有机钙为主的钙制剂存在于市面上，然而这种钙制剂含量低，价格高的缺点，不受广大消费者欢迎。
发明内容
鉴于上述问题，本发明的目的在于提供一种提供多种钙源且钙含量高，及胃肠道刺激较低和口感好的钙软胶囊及制备方法。
为实现上述目的，本发明提供的一种钙软胶囊，其中，包括胶皮囊，及在胶皮囊内封装的钙物料液，所述的钙物料液包括磷酸三钙30％、柠檬酸钙10％、L-乳酸钙3％、核桃油56.6％、蜂蜡0.39％、甜菊糖苷0.01％。胶皮囊包括60％的明胶、26％的甘油、3％的二氧化钛和11％的纯化水。
本发明另一目的是提供一种钙物料液包括磷酸三钙33％、柠檬酸钙8％、L-乳酸钙2％、核桃油54.5％、蜂蜡0.5％、甜橙香精1.982％、甜菊糖苷0.018％。胶皮囊包括62的明胶、32％的甘油、1％的二氧化钛和5％的纯化水。
本发明另一目的是提供一种钙物料液包括磷酸三钙40％、柠檬酸钙5％、L-乳酸钙2％、核桃油50％、蜂蜡1.982％、甜橙香精1％、甜菊糖苷0.018％。胶皮囊包括68的明胶、26％的甘油、1％的二氧化钛和5％的纯化水。
本发明另一目的是提供一种钙软胶囊的制备方法，其中，具体步骤如下：(1)称量和过筛
按照配方量称取经检验合格后的原辅料备用，所述的原辅料包括高细度的磷酸三钙、高细度的柠檬酸钙、高细度的L-乳酸钙、蜂蜡、核桃油、甜橙香精、甜菊糖苷、明胶、甘油、纯化水、二氧化钛；
(2)钙物料液的配制
A、取适量的核桃油，按照配方量的甜橙香精混用于核桃油备用；B、取称量好的蜂蜡与经混用后的核桃油加热至60-70℃，使蜂蜡熔融备用；C、取配方量甜菊糖苷和适量磷酸三钙混合过100目筛后，再与高细度的磷酸三钙、高细度的柠檬酸钙和高细度的L-乳酸钙混合，后加入熔融后的蜂蜡搅拌，过胶体磨研磨2-3次，制得钙物料液备用。
(3)胶皮囊配制
A、取按照配方量的明胶、甘油、纯化水、二氧化钛；B、将甘油、纯化水置于化胶罐中加热至65～80℃；C、投入明胶、二氧化钛并升温至70～80℃，搅拌熬制1-2h，待明胶全部熔融；D、抽真空脱泡在-0.06MPa～-0.08MPa的条件下，出胶和滤过100目筛，60±5℃保温备用；
(4)压丸出粒
A、将钙物料液用输料管输送至软胶囊机的储料槽中；B、将制备好的囊皮胶液用输料管输送到软胶囊机的储胶槽中并保温至60±5℃；C、开动软胶囊机，压制每粒胶丸出粒。
在一些实施方式中，高细度的磷酸三钙为1200目的磷酸三钙；所述高细度的柠檬酸钙为1200目的柠檬酸钙；所述高细度的L-乳酸钙为1200目的L-乳酸钙，由此，磷酸三钙、柠檬酸钙和L-乳酸钙均为颗粒大小控制在10微米以下。
在一些实施方式中，胶丸的长度为2-3cm，宽度为1-1.5cm。本发明的有益效果是具有提供多种钙源且钙含量高，及胃肠道刺激较低和口感好的效果。具体如下：(1)磷酸三钙10％—90％为无机酸螯合钙，应用于普遍存在钙含量高(38％)的人体骨骼中不溶于水溶于酸、可在胃酸中溶解、不产生气体对肠胃刺激小。柠檬酸钙1-20％为有机酸螯合钙，吸收不依赖胃酸，对肠胃刺激小和钙含量较低(24％)，难溶于水(0.1g/100mL，25℃)，吸收慢。L-乳酸钙1-20％为有机酸螯合钙，吸收不依赖胃酸、对肠胃刺激小、钙含量低(18％)、极易溶于水，吸收较快。采用的植物油0-80％为基础填充剂，与蜂蜡经均质乳化工艺形成多相悬浮乳液均匀分散承载。钙粉食用香料或香精0％-5％矫味剂，则可提供香味，掩盖其它配料产生的不良气味。甜味剂0％-5％代替糖，可提供甜味和不会导致蛀牙。蜂蜡0％-5％为乳化剂和植物油经均质乳化工艺形成多相悬浮乳液均匀分散承载钙粉。(2)高细度的磷酸三钙为1200目的磷酸三钙；所述高细度的柠檬酸钙为1200目的柠檬酸钙；所述高细度的L-乳酸钙为1200目的L-乳酸钙，由此，磷酸三钙、柠檬酸钙和L-乳酸钙均为颗粒大小控制在10微米以下。目的在于减低钙颗粒大小，增加单位重量表面积，使钙粉更好的与胃肠道接触，帮助吸收。所以本发明具有提供多种钙源，提供高钙含量的同时，也适当降低纯有机钙的成本。另外，特定规格的钙源解决了钙软胶囊制剂的口感、规格及对胃肠道的刺激的问题。
具体实施方式
下面对发明作进一步详细的说明。
实施例1
钙软胶囊，包括胶皮囊，及在胶皮囊内封装的钙物料液，所述的钙物料液包括磷酸三钙30％、柠檬酸钙10％、L-乳酸钙3％、核桃油56.6％、蜂蜡0.39％、甜菊糖苷0.01％。胶皮囊包括60％的明胶、26％的甘油、3％的二氧化钛和11％的纯化水。
实施例2是在上述基础上进行变形设计,上述的钙物料液包括磷酸三钙33％、柠檬酸钙8％、L-乳酸钙2％、核桃油54.5％、蜂蜡0.5％、甜橙香精1.982％、甜菊糖苷0.018％。胶皮囊包括62的明胶、32％的甘油、1％的二氧化钛和5％的纯化水。上述的甜橙香精可采用草莓香精或者苹果香精代替或者不加香精。
实施例3是在上述基础上进行变形设计,上述的钙物料液包括磷酸三钙40％、柠檬酸钙5％、L-乳酸钙2％、核桃油50％、蜂蜡1.982％、甜橙香精1％、甜菊糖苷0.018％。胶皮囊包括68的明胶、26％的甘油、1％的二氧化钛和5％的纯化水。上述的甜橙香精可采用草莓香精或者苹果香精代替或者不加香精。
上述核桃油(植物油)：类同的有葵花籽油、菜籽油、橄榄油、花生油、芝麻油、棕榈油、大豆油、玉米油。蜂蜡(乳化剂)：巴西棕榈蜡、单，双甘油脂肪酸酯。甜橙香精(食用香料香精)：橘子、苹果、草莓、椰子、香蕉、蓝莓、菠萝、芒果、荔枝。甜菊糖苷(甜味剂)：三氯蔗糖、麦芽糖醇、阿斯巴甜。二氧化钛(食用色素):焦糖色、可可壳色、辣椒橙、辣椒红、萝卜红、玫瑰茄红、葡萄皮红、天然苋菜红、甜菜红、栀子蓝、栀子黄、红氧化铁。
一种钙软胶囊的制备方法，其中，具体步骤如下：(1)称量和过筛。按照配方量称取经检验合格后的原辅料备用，所述的原辅料包括高细度的磷酸三钙、高细度的柠檬酸钙、高细度的L-乳酸钙、蜂蜡、核桃油、甜橙香精、甜菊糖苷、明胶、甘油、纯化水、二氧化钛。(2)钙物料液的配制。A、取适量的核桃油，按照配方量的甜橙香精混用于核桃油备用；B、取称量好的蜂蜡与经混用后的核桃油加热至60-70℃，使蜂蜡熔融备用；C、取配方量甜菊糖苷和适量磷酸三钙混合过100目筛后，再与高细度的磷酸三钙、高细度的柠檬酸钙和高细度的L-乳酸钙混合，后加入熔融后的蜂蜡搅拌，过胶体磨研磨2-3次，制得钙物料液备用。(3)胶皮囊配制。A、取按照配方量的明胶、甘油、纯化水、二氧化钛；B、将甘油、纯化水置于化胶罐中加热至65～80℃；C、投入明胶、二氧化钛并升温至70～80℃，搅拌熬制1-2h，待明胶全部熔融；D、抽真空脱泡在-0.06MPa～-0.08MPa的条件下，出胶和滤过100目筛，60±5℃保温备用。(4)压丸出粒。A、将钙物料液用输料管输送至软胶囊机的储料槽中；B、将制备好的囊皮胶液用输料管输送到软胶囊机的储胶槽中并保温至60±5℃；C、开动软胶囊机，压制每粒胶丸出粒。高细度的磷酸三钙为1200目的磷酸三钙；所述高细度的柠檬酸钙为1200目的柠檬酸钙；所述高细度的L-乳酸钙为1200目的L-乳酸钙，磷酸三钙、柠檬酸钙和L-乳酸钙均为颗粒大小控制在10微米以下。胶丸的长度为2-3cm，宽度为1-1.5cm。
应用效果磷酸三钙10％—90％为无机酸螯合钙，应用于普遍存在钙含量高(38％)的人体骨骼中不溶于水溶于酸、可在胃酸中溶解、不产生气体对肠胃刺激小。柠檬酸钙1-20％为有机酸螯合钙，吸收不依赖胃酸，对肠胃刺激小和钙含量较低(24％)，难溶于水(0.1g/100mL，25℃)，吸收慢。L-乳酸钙1-20％为有机酸螯合钙，吸收不依赖胃酸、对肠胃刺激小、钙含量低(18％)、极易溶于水，吸收较快。采用的植物油0-80％为基础填充剂，与蜂蜡经均质乳化工艺形成多相悬浮乳液均匀分散承载。钙粉食用香料或香精0％-5％矫味剂，则可提供香味，掩盖其它配料产生的不良气味。甜味剂0％-5％代替糖，可提供甜味和不会导致蛀牙。蜂蜡0％-5％为乳化剂和植物油经均质乳化工艺形成多相悬浮乳液均匀分散承载钙粉。高细度的磷酸三钙为1200目的磷酸三钙；所述高细度的柠檬酸钙为1200目的柠檬酸钙；所述高细度的L-乳酸钙为1200目的L-乳酸钙，由此，磷酸三钙、柠檬酸钙和L-乳酸钙均为颗粒大小控制在10微米以下。目的在于减低钙颗粒大小，增加单位重量表面积，使钙粉更好的与胃肠道接触，帮助吸收。
以上所述的仅是本发明的一些实施方式。对于本领域的普通技术人员来说，在不脱离本发明创造构思的前提下，还可以做出若干变形和改进，这些都属于发明的保护范围。
Claims (6)
1.钙软胶囊，其特征在于，包括胶皮囊，及在胶皮囊内封装的钙物料液，所述的钙物料液包括磷酸三钙30％、柠檬酸钙10％、L-乳酸钙3％、核桃油56.6％、蜂蜡0.39％、甜菊糖苷0.01％；
所述的胶皮囊包括60％的明胶、26％的甘油、3％的二氧化钛和11％的纯化水。
2.根据权利要求1所述的钙软胶囊，其特征在于，所述的钙物料液包括磷酸三钙33％、柠檬酸钙8％、L-乳酸钙2％、核桃油54.5％、蜂蜡0.5％、甜橙香精1.982％、甜菊糖苷0.018％；
所述的胶皮囊包括62的明胶、32％的甘油、1％的二氧化钛和5％的纯化水。
3.根据权利要求1所述的钙软胶囊，其特征在于，所述的钙物料液包括磷酸三钙40％、柠檬酸钙5％、L-乳酸钙2％、核桃油50％、蜂蜡1.982％、甜橙香精1％、甜菊糖苷0.018％；
所述的胶皮囊包括68的明胶、26％的甘油、1％的二氧化钛和5％的纯化水。
4.钙软胶囊的制备方法，其中，具体步骤如下：
(1)称量和过筛
按照配方量称取经检验合格后的原辅料备用，所述的原辅料包括高细度的磷酸三钙、高细度的柠檬酸钙、高细度的L-乳酸钙、蜂蜡、核桃油、甜橙香精、甜菊糖苷、明胶、甘油、纯化水、二氧化钛；
(2)钙物料液的配制
A、取适量的核桃油，按照配方量的甜橙香精混用于核桃油备用；
B、取称量好的蜂蜡与经混用后的核桃油加热至60-70℃，使蜂蜡熔融，备用；
C、取配方量甜菊糖苷和适量磷酸三钙混合过100目筛后，再与高细度的磷酸三钙、高细度的柠檬酸钙和高细度的L-乳酸钙混合，后加入熔融后的蜂蜡搅拌，过胶体磨研磨2-3次，制得钙物料液备用；
(3)胶皮囊配制
A、取按照配方量的明胶、甘油、纯化水、二氧化钛；
B、将甘油、纯化水置于化胶罐中加热至65～80℃；
C、投入明胶、二氧化钛并升温至70～80℃，搅拌熬制1-2h，待明胶全部熔融；
D、抽真空脱泡在-0.06MPa～-0.08MPa的条件下，出胶和滤过100目筛，60±5℃保温备用；
(4)压丸出粒
A、将钙物料液用输料管输送至软胶囊机的储料槽中；
B、将制备好的囊皮胶液用输料管输送到软胶囊机的储胶槽中并保温至60±5℃；
C、开动软胶囊机，压制每粒胶丸出粒；
D、灯检和选拣去除非正型丸，得正型胶软囊。
5.根据权利要求4所述的钙软胶囊的制备方法，其特征在于，所述高细度的磷酸三钙为1200目的磷酸三钙；所述高细度的柠檬酸钙为1200目的柠檬酸钙；所述高细度的L-乳酸钙为1200目的L-乳酸钙。
6.根据权利要求4所述的钙软胶囊的制备方法，其特征在于，所述胶丸的长度为2-3cm，宽度为1-1.5cm。
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