CN108542980A - A kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid - Google Patents
A kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid Download PDFInfo
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Abstract
The invention discloses a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid, are related to technical field of traditional Chinese medicines, and a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid includes the following steps：（1）Prepare wine liquid；（2）The microporous barrier for the use of pore size being 46 microns is filtered wine liquid, the Chinese Drug Gualouzi wine prepared up to the present invention is full of nutrition, mouthfeel is excellent, it dehumidifies with cold extermination relieve heat, promoting blood circulation, dredging meridian and relieving pain and other effects, not only the custom that people drink had been met, but also rheumatism paralysis can be treated, has been a kind of effective medicinal liquor for treating rheumatism and rheumatoid.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid.
Background technology
Rheumatoid arthritis (Rheumatoid arthrities, RA) is a kind of etiology unknown, based on arthropathy
Chronic generalized immunity disease, it is clinical to show as symmetry, chronic, progressive panarthritis, affected joints swelling, pain more
Bitterly, activity is unfavorable, and function of joint is impaired, such as cannot timely diagnosing and treating, joint stiffness, deformity can be developed into, disabled and tight
Ghost image rings the health and quality of life of patient.Rheumatoid arthritis incidence is higher, and each race has morbidity, at itself
Its illness rate row are the first in immunity connective tissue disease, are a kind of common diseases endangering health of people, seriously affect the labor of patient
Kinetic force has become universally acknowledged one of refractory disease.
Rheumatism is treated in the prior art and the medicament active constituent content of rheumatoid is low, and stability is poor, effect unobvious.
Invention content
The purpose of the present invention is for existing problem, provide a kind of Chinese Drug Gualouzi for treating rheumatism and rheumatoid
Wine.
The present invention is achieved by the following technical solutions：
A kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid includes the following steps：
（1）Following raw material is weighed in parts by weight：Ferment 100-110 parts of Chinese Drug Gualouzi, 30-35 parts of lycopodium calvatum, Poria cocos 30-35
Part, 10-15 parts of silkworm excrement, 3-6 parts of caulis sinomenii, 0.12-0.18 parts of activated yeast, will fermentation Chinese Drug Gualouzi, lycopodium calvatum, Poria cocos, silkworm excrement,
Caulis sinomenii drains surface moisture after cleaning up, and carries out crushing and beating using tissue mashing machine, is crushed to 80 mesh, is mixed
Then material adds 5 times of clear water of its quality into mixture, be beaten 10min, obtain slurries, activated yeast is added into slurries, stir
It mixes uniformly, when then soluble solid content is 15% in ferment at constant temperature to liquid at 23 DEG C, is filtered, obtains wine liquid；
（2）Using pore size be 4-6 microns microporous barrier to wine liquid be filtered to get.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 80, rush 15, mountain
Tea seed 10, Scabrous Mosla Herb 12.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, rush, camellia seed, Scabrous Mosla Herb, drying to moisture content to 8%, powder are weighed by weight
It is broken, it sieves with 100 mesh sieve, is uniformly mixed, obtains mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus
In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 3 times of clear water of its quality stir evenly, slurries obtained, into slurries
The bacillus cereus bacterium solution for adding its quality 2.5% ferments 2.5 hours at 30 DEG C, then carries out steam sterilizing, sent out
Zymotic fluid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure
The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.2 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the excrement when silkworm excrement is three dormancy.
Further, the silkworm excrement is by pretreatment：It is 0.5% sodium salicylate solution in 40 DEG C of water to use mass fraction
The lower constant temperature of bath impregnates 2 hours, is then evaporated concentration, drying to constant weight, you can.
Further, described a kind of for treating rheumatism and the Chinese Drug Gualouzi wine application method of rheumatoid can be by 1:5 matter
Amount ratio, which is watered, drinks, or presses 1:2 mass ratios, which are watered, wipes affected part.
The present invention has the following advantages compared with prior art：Chinese Drug Gualouzi wine prepared by the present invention is full of nutrition, and mouthfeel is excellent,
It dehumidifies with cold extermination relieve heat, promoting blood circulation, dredging meridian and relieving pain and other effects had not only met the custom that people drink, but also can treat rheumatism fiber crops
Numbness is a kind of effective medicinal liquor for treating rheumatism and rheumatoid, meanwhile, the fermentation Chinese Drug Gualouzi that the present invention adds stops with cold dispelling
Bitterly, relaxing tendons and activating collaterals, anti-inflammatory analgesic, promoting circulation of blood latus rectum, removing blood stasis and analgesics, strengthening the muscles and bones promoting blood circulation and removing blood stasis and other effects；Prepared by the present invention controls
The Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid treats rheumatism significant effect, by adding the fermentation Chinese Drug Gualouzi energy prepared in the present invention
The effect for the treatment of rheumatism is enough greatly improved, and uses the reduction with obvious effects of Chinese Drug Gualouzi abrasive flour, does not add rush, mountain
Tea seed, Scabrous Mosla Herb can influence the effect of Chinese Drug Gualouzi wine treatment rheumatism.
Specific implementation mode
Embodiment 1
A kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid includes the following steps：
（1）Following raw material is weighed in parts by weight：Ferment 100 parts of Chinese Drug Gualouzi, 30 parts of lycopodium calvatum, 30 parts of Poria cocos, 10 parts of silkworm excrement,
3 parts of caulis sinomenii, 0.12 part of activated yeast drain table after cleaning up fermentation Chinese Drug Gualouzi, lycopodium calvatum, Poria cocos, silkworm excrement, caulis sinomenii
Face moisture carries out crushing and beating using tissue mashing machine, is crushed to 80 mesh, obtains mixture, then add it into mixture
5 times of clear water of quality are beaten 10min, obtain slurries, activated yeast is added into slurries, stir evenly, then the constant temperature at 23 DEG C
When fermentation to soluble solid content in liquid is 15%, it is filtered, obtains wine liquid；
（2）Using pore size be 4-6 microns microporous barrier to wine liquid be filtered to get.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 80, rush 15, mountain
Tea seed 10, Scabrous Mosla Herb 12.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, rush, camellia seed, Scabrous Mosla Herb, drying to moisture content to 8%, powder are weighed by weight
It is broken, it sieves with 100 mesh sieve, is uniformly mixed, obtains mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus
In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 3 times of clear water of its quality stir evenly, slurries obtained, into slurries
The bacillus cereus bacterium solution for adding its quality 2.5% ferments 2.5 hours at 30 DEG C, then carries out steam sterilizing, sent out
Zymotic fluid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure
The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.2 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the excrement when silkworm excrement is three dormancy.
Further, the silkworm excrement is by pretreatment：It is 0.5% sodium salicylate solution in 40 DEG C of water to use mass fraction
The lower constant temperature of bath impregnates 2 hours, is then evaporated concentration, drying to constant weight, you can.
Further, described a kind of for treating rheumatism and the Chinese Drug Gualouzi wine application method of rheumatoid can be by 1:5 matter
Amount ratio, which is watered, drinks, or presses 1:2 mass ratios, which are watered, wipes affected part.
Embodiment 2
A kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid includes the following steps：
（1）Following raw material is weighed in parts by weight：Ferment 110 parts of Chinese Drug Gualouzi, 35 parts of lycopodium calvatum, 35 parts of Poria cocos, 15 parts of silkworm excrement,
6 parts of caulis sinomenii, 0.18 part of activated yeast drain table after cleaning up fermentation Chinese Drug Gualouzi, lycopodium calvatum, Poria cocos, silkworm excrement, caulis sinomenii
Face moisture carries out crushing and beating using tissue mashing machine, is crushed to 80 mesh, obtains mixture, then add it into mixture
5 times of clear water of quality are beaten 10min, obtain slurries, activated yeast is added into slurries, stir evenly, then the constant temperature at 23 DEG C
When fermentation to soluble solid content in liquid is 15%, it is filtered, obtains wine liquid；
（2）Using pore size be 4-6 microns microporous barrier to wine liquid be filtered to get.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 80, rush 15, mountain
Tea seed 10, Scabrous Mosla Herb 12.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, rush, camellia seed, Scabrous Mosla Herb, drying to moisture content to 8%, powder are weighed by weight
It is broken, it sieves with 100 mesh sieve, is uniformly mixed, obtains mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus
In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 3 times of clear water of its quality stir evenly, slurries obtained, into slurries
The bacillus cereus bacterium solution for adding its quality 2.5% ferments 2.5 hours at 30 DEG C, then carries out steam sterilizing, sent out
Zymotic fluid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure
The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.2 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the excrement when silkworm excrement is three dormancy.
Further, the silkworm excrement is by pretreatment：It is 0.5% sodium salicylate solution in 40 DEG C of water to use mass fraction
The lower constant temperature of bath impregnates 2 hours, is then evaporated concentration, drying to constant weight, you can.
Further, described a kind of for treating rheumatism and the Chinese Drug Gualouzi wine application method of rheumatoid can be by 1:5 matter
Amount ratio, which is watered, drinks, or presses 1:2 mass ratios, which are watered, wipes affected part.
Embodiment 3
A kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid includes the following steps：
（1）Following raw material is weighed in parts by weight：Ferment 105 parts of Chinese Drug Gualouzi, 32 parts of lycopodium calvatum, 32 parts of Poria cocos, 13 parts of silkworm excrement,
5 parts of caulis sinomenii, 0.15 part of activated yeast drain table after cleaning up fermentation Chinese Drug Gualouzi, lycopodium calvatum, Poria cocos, silkworm excrement, caulis sinomenii
Face moisture carries out crushing and beating using tissue mashing machine, is crushed to 80 mesh, obtains mixture, then add it into mixture
5 times of clear water of quality are beaten 10min, obtain slurries, activated yeast is added into slurries, stir evenly, then the constant temperature at 23 DEG C
When fermentation to soluble solid content in liquid is 15%, it is filtered, obtains wine liquid；
（2）Using pore size be 4-6 microns microporous barrier to wine liquid be filtered to get.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 80, rush 15, mountain
Tea seed 10, Scabrous Mosla Herb 12.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, rush, camellia seed, Scabrous Mosla Herb, drying to moisture content to 8%, powder are weighed by weight
It is broken, it sieves with 100 mesh sieve, is uniformly mixed, obtains mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus
In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 3 times of clear water of its quality stir evenly, slurries obtained, into slurries
The bacillus cereus bacterium solution for adding its quality 2.5% ferments 2.5 hours at 30 DEG C, then carries out steam sterilizing, sent out
Zymotic fluid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure
The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.2 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the excrement when silkworm excrement is three dormancy.
Further, the silkworm excrement is by pretreatment：It is 0.5% sodium salicylate solution in 40 DEG C of water to use mass fraction
The lower constant temperature of bath impregnates 2 hours, is then evaporated concentration, drying to constant weight, you can.
Further, described a kind of for treating rheumatism and the Chinese Drug Gualouzi wine application method of rheumatoid can be by 1:5 matter
Amount ratio, which is watered, drinks, or presses 1:2 mass ratios, which are watered, wipes affected part.
Comparative example 1：It is differed only in embodiment 1 and does not add fermentation Chinese Drug Gualouzi.
Comparative example 2：It is differed only in embodiment 1 and fermentation Chinese Drug Gualouzi is replaced with into Chinese Drug Gualouzi grounds travel.
Comparative example 3：It is differed only in embodiment 1 and does not add rush, camellia seed, Scabrous Mosla Herb.
Patient is grouped：700 patients are all from the rheumatism of hospital outpatient, rheumatoid patient, age 20-65 Sui, course of disease 1-3
Year, it is divided into 7 groups, every group of 100 people, there was no significant difference for each group age, gender, state of an illness etc., is comparable.
Therapy：Using embodiment and comparative example ointment as medicine, 1 is pressed every time:5 mass ratios, which are watered, to be drunk,
Each amount of drinking is 50g, and 2 times a day, 15d is 1 course for the treatment of, after treating 2 courses for the treatment of, comparison；
Judge curative effect；Patient avoids eating scorching food during treatment；
Curative effect determinate standard：
It cures：Clinical symptoms all disappear, and indices check that normally, observation has no repeatedly for 3 months；
Effectively：Clinical symptom relief, the state of an illness are controlled, and indices inspection makes moderate progress；
In vain：No significant improvement or aggravated in clinical symptoms；
1 clinical efficacy test result of table
Control group uses application number application number：201511011792.3 wind-damp dispelling wine；
As can be seen from Table 1, the Chinese Drug Gualouzi wine for the treatment rheumatism and rheumatoid that prepared by the present invention treats rheumatism significant effect, leads to
The effect for the treatment of rheumatism can be greatly improved by crossing the fermentation Chinese Drug Gualouzi prepared in the addition present invention, and Chinese Drug Gualouzi is used to grind
Powder reduction with obvious effects, the effect of Chinese Drug Gualouzi wine treatment rheumatism can be influenced by not adding rush, camellia seed, Scabrous Mosla Herb.
Claims (8)
1. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid, which is characterized in that include the following steps：
（1）Following raw material is weighed in parts by weight：Ferment 100-110 parts of Chinese Drug Gualouzi, 30-35 parts of lycopodium calvatum, Poria cocos 30-35
Part, 10-15 parts of silkworm excrement, 3-6 parts of caulis sinomenii, 0.12-0.18 parts of activated yeast, will fermentation Chinese Drug Gualouzi, lycopodium calvatum, Poria cocos, silkworm excrement,
Caulis sinomenii drains surface moisture after cleaning up, and carries out crushing and beating using tissue mashing machine, is crushed to 80 mesh, is mixed
Then material adds 5 times of clear water of its quality into mixture, be beaten 10min, obtain slurries, activated yeast is added into slurries, stir
It mixes uniformly, when then soluble solid content is 15% in ferment at constant temperature to liquid at 23 DEG C, is filtered, obtains wine liquid；
（2）Using pore size be 4-6 microns microporous barrier to wine liquid be filtered to get.
2. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid according to claim 1, which is characterized in that described
Fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 80, rush 15, camellia seed 10, Scabrous Mosla Herb 12.
3. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid according to claim 2, which is characterized in that described
Fermentation Chinese Drug Gualouzi preparation method be：
（1）Detach volatile oil：Chinese Drug Gualouzi, rush, camellia seed, Scabrous Mosla Herb, drying to moisture content to 8%, powder are weighed by weight
It is broken, it sieves with 100 mesh sieve, is uniformly mixed, obtains mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus
In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 3 times of clear water of its quality stir evenly, slurries obtained, into slurries
The bacillus cereus bacterium solution for adding its quality 2.5% ferments 2.5 hours at 30 DEG C, then carries out steam sterilizing, sent out
Zymotic fluid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
4. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid according to claim 3, which is characterized in that described
Supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, the flow of extracting pressure 18MPa, carbon dioxide are
10kg/h。
5. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid according to claim 3, which is characterized in that described
Bacillus cereus content is 1.2 × 10 in bacillus cereus bacterium solution3cfu/mL。
6. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid according to claim 1, which is characterized in that described
Excrement when silkworm excrement is three dormancy.
7. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid according to claim 1 or 6, which is characterized in that
The silkworm excrement is by pretreatment：Using mass fraction, the constant temperature under 40 DEG C of water-baths impregnates 2 hours for 0.5% sodium salicylate solution,
Then it is evaporated concentration, drying to constant weight, you can.
8. a kind of Chinese Drug Gualouzi wine for treating rheumatism and rheumatoid according to claim 1, which is characterized in that described
It is a kind of for treating rheumatism and the Chinese Drug Gualouzi wine application method of rheumatoid can be by 1:5 mass ratios, which are watered, to be drunk, or presses 1:2
Mass ratio, which is watered, wipes affected part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166318A (en) * | 2010-12-21 | 2011-08-31 | 徐士付 | Chinese medicated wine for treating rheumatoid disease |
| CN105477508A (en) * | 2016-01-26 | 2016-04-13 | 天津安之和合基因科技有限公司 | Traditional Chinese medicine formula for treating rheumatism and rheumatoid arthritis and preparation method thereof |
| CN105687299A (en) * | 2016-02-27 | 2016-06-22 | 赵百华 | Liquor containing poria cocos and silkworm excrement |
| JP2016222729A (en) * | 2016-10-04 | 2016-12-28 | 小林製薬株式会社 | Granulated substance including kamishimotsuto extract powder |
| CN107028137A (en) * | 2017-03-13 | 2017-08-11 | 蚌埠清菲农业科技有限公司 | A kind of frying production method of Chinese Drug Gualouzi |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166318A (en) * | 2010-12-21 | 2011-08-31 | 徐士付 | Chinese medicated wine for treating rheumatoid disease |
| CN105477508A (en) * | 2016-01-26 | 2016-04-13 | 天津安之和合基因科技有限公司 | Traditional Chinese medicine formula for treating rheumatism and rheumatoid arthritis and preparation method thereof |
| CN105687299A (en) * | 2016-02-27 | 2016-06-22 | 赵百华 | Liquor containing poria cocos and silkworm excrement |
| JP2016222729A (en) * | 2016-10-04 | 2016-12-28 | 小林製薬株式会社 | Granulated substance including kamishimotsuto extract powder |
| CN107028137A (en) * | 2017-03-13 | 2017-08-11 | 蚌埠清菲农业科技有限公司 | A kind of frying production method of Chinese Drug Gualouzi |
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Application publication date: 20180918 |
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