CN104689176B - A kind of Chinese medicine preparation for treating knee osteoarthritis and preparation method thereof - Google Patents
A kind of Chinese medicine preparation for treating knee osteoarthritis and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine preparation for treating knee osteoarthritis, and the Chinese medicine preparation is made up of following Chinese medicine material：The rhizome of davallia, the root of herbaceous peony, radix glycyrrhizae, semen brassicae, the Radix Astragali, honeycomb, levisticum, teasel, the red sage root, corydalis tuber, Common St.Paulswort Herb, Bi Collettiis, smilax, cucumber and flax benevolence.The Chinese medicine preparation of the present invention, Chinese medicine material used, can conveniently be bought in pharmacy, and cost is cheap, and preparation method is also simple, and manufactured Chinese medicine preparation toxic side effect is small, and fast, easy to absorb, short treating period is absorbed in alimentary canal, and cure rate is high.Though flavour of a drug are more, prescription is rigorous, and monarch, compatibility is proper, and hit the interpretation of the cause, onset and process of an illness.It is clinically used for treating osteoarthritis, has been reduced or avoided caused by Western medicine non-steroid anti-inflammatory drug, regulation Bone m etabolism medicine and glucocorticoid and has applied, caused toxicity in therapeutic process has been reduced or avoided to greatest extent.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine preparation for treating knee osteoarthritis and its preparation side
Method.
Background technology
Knee osteoarthritis is clinically to continue a kind of chronic, the kneed frequently-occurring disease of progress assault sexually and common disease.Be with
Joint defunctionalization, joint margins spur caused by articular cartilage degeneration, joint wear are formed, soft tissue chronic strain outside joint
With the disease that degenerative change is pathological characteristicses.With the development of lesion severity, some patients may finally disable.With
The arrival of China's aging society, knee osteoarthritis has turned into one of most common reason of the chronic disability of the elderly.The disease
Generation may increase with the age, normal abrasion, the excessively close phase of many factors such as use, chronic injury, heredity, environment
Close, obesity, diet etc. are all probably pathogenic factors.Shown according to documents and materials：More than 60 years old crowds, almost 100% has knee pass
Save the histological appearance of retrogression, the x-ray sign of 60%~80% visible osteoarthritis, wherein 20% has pain and active receiving
Limit, the domestic incidence of disease are up to 8.3%.Patient's Chang Yin gonalgias are unbearably seen a doctor.Blood test：Erythrocyte sedimentation rate is normal or slightly higher.
Knee joint x-ray plain film early stage and Non Apparent Abnormality, about several years rear engenders that joint space is narrow, now shows articular cartilage
Have started to thinning.During beginning, joint space is normal when not bearing a heavy burden, and occurs after load-bearing narrow.Lesion later stage, joint space have aobvious
Write it is narrow, can have under cartilage it is micro- fracture sign, then there is osteosclerosis, last joint margins come to a point, and have spur to be formed.CT and
MRI is checked can be in the abnormal change of early detection articular cartilage and subchondral bone matter.
Osteoarthritis belongs to the categories such as " heumatism " of the traditional Chinese medical science, " bi Zheng ".In the traditional Chinese medical science thinks that this sick occurrence and development has
Outer two big factor.External cause is relevant with the invasion and attack of the damp and hot perverse trend of chill, and internal cause is then relevant with the imbalance of the function such as liver and spleen kidney.Face
Bed is dialectical to be divided into wind cold wetness type, wind wetness heat type, type of obstruction of phlegm and blood stasis, deficiency of the liver and kidney.
At present, treatment knee osteoarthritis mainly uses drug therapy and surgical operation therapy.Drug therapy, including non-steroidal
Anti-inflammatory analgesic medicine, glucocorticoid, hyaluronic acid, GLUCOSAMINE, poly glucosamine.Operative treatment includes arthroscope lavation art
With joint debridement art, Drilling, osteotomy, cartilage and chondrocyte cell transplantation art under cartilage by joint, artificial substratum application and
Artificial joint replacement.Following defect in general be present in above-mentioned two big method：Due to needing long-term use when drug application is treated
Medicine, easily cause a variety of discomforts.Such as nonsteroidal anti-inflammatory anodyne, easily cause upset,gastro-intestinal, headache, dizziness and kidney function damage；
Using glucocorticoid, blood pressure, blood glucose, blood fat and the Bone m etabolism of patient are easily influenceed, induces or aggravates peptic ulcer.It is and outer
One big weak point of surgical treatment is then that economic costs are huge.Therefore, research and develop it is a kind of have no toxic side effect, therapeutic effect it is good
The medicine for treating osteoarthritis is urgent problem to be solved.
The content of the invention
For above-mentioned prior art, the invention provides it is a kind of have no toxic side effect, the treatment kneecap joint that therapeutic effect is good
Scorching Chinese medicine preparation, and provide its preparation method.
The present invention is achieved by the following technical solutions：
A kind of Chinese medicine preparation for treating knee osteoarthritis, it is made of the bulk drug including following parts by weight：The rhizome of davallia
20~30 parts, 45~60 parts of the root of herbaceous peony, 10~15 parts of radix glycyrrhizae, 12~18 parts of semen brassicae, 15~30 parts of the Radix Astragali, 9~12 parts of honeycomb, solely
Living 30~40 parts, 10~20 parts of teasel, 15~30 parts of the red sage root, 45~60 parts of, Bi Collettiis 30~40 of Fen, Common St.Paulswort Herbs of corydalis tuber 10~20
Part, 20~30 parts of smilax, 20~30 parts of cucumber sub (smashing to pieces), 20~30 parts of flax benevolence.
Preferably, it is made of the bulk drug of following parts by weight：30 parts of the rhizome of davallia, 60 parts of the root of herbaceous peony, 15 parts of radix glycyrrhizae, sinapsis alba
18 parts of son, 30 parts of the Radix Astragali, 12 parts of honeycomb, 40 parts of levisticum, 20 parts of teasel, 30 parts of the red sage root, 60 parts of the Fen, Common St.Paulswort Herbs of corydalis tuber 20, Bi
30 parts of 40 parts of Collettii, 30 parts of smilax, cucumber sub (smashing to pieces), 30 parts of flax benevolence.
Further, the bulk drug of following parts by weight is included：6~9 parts of Soil unit, 9~12 parts of the wind-weed is (if conditions of patients
Relatively light, chemical examination erythrocyte sedimentation rate is normal, then both bulk drugs can not have to；If conditions of patients is more serious, or erythrocyte sedimentation rate compared with
It hurry up, or have adstante febre, then have more preferable clinical effectiveness after both medicines are added.).
Preferably, it is made of the bulk drug of following parts by weight：30 parts of the rhizome of davallia, 60 parts of the root of herbaceous peony, 15 parts of radix glycyrrhizae, sinapsis alba
18 parts of son, 30 parts of the Radix Astragali, 12 parts of honeycomb, 40 parts of levisticum, 20 parts of teasel, 30 parts of the red sage root, 60 parts of the Fen, Common St.Paulswort Herbs of corydalis tuber 20, Bi
30 parts of 40 parts of Collettii, 30 parts of smilax, cucumber sub (smashing to pieces), 30 parts of flax benevolence, 6 parts of Soil unit, 9 parts of the wind-weed.
The preparation method of Chinese medicine preparation of the treatment knee osteoarthritis is：In addition to flax benevolence, each bulk drug is taken, is soaked together
Enter in water, by submergence be defined, immersion 90~150 minutes (summer preferably 90~120 clocks, preferably 120~150 minutes other seasons,
Most preferably 150 minutes), then it is cooked by slow fire 20~30 minutes, pours out 300 milliliters of decoction.Afterwards boil for second time, add cool
Appropriate amount of water, after being cooked by slow fire 20~30 minutes, then pour out 300 milliliters of decoction.Decoct twice and there are 600 milliliters of decoctions.Take recklessly
Edestan is smashed to pieces or ground, and is sprinkled into 600 milliliters of decoctions, obtains decoction, as treats the Chinese medicine preparation of knee osteoarthritis.
The property of medicine of bulk drug used in the present invention is as follows：
The rhizome of davallia：Bitter, it is warm-natured.Return liver and kidney channel.The strong bone of kidney tonifying, continues and hinders pain relieving, promoting blood circulation and hemostasis.
Teasel：Bitter, pungent, slightly warm in nature.Return liver, kidney channel.Energy filling liver kidney, strong waist and knee, promoting circulation of blood detumescence, myogenic pain relieving, continue
Muscle synthetism.
The Radix Astragali：It is sweet, slightly warm in nature.Return lung, spleen, liver and kidney channel.Invigorating qi for strengthening superficies, hidroschesis detoxification, myogenic, diuresis, detumescence.
The red sage root：Bitter, cold nature.The thoughts of returning home, Liver Channel.Energy promoting blood circulation, inducing meastruation to relieve menalgia, cool blood to disappear carbuncle.
Corydalis tuber：Acrid flavour, hardship, it is warm-natured.Return liver, the spleen channel.There are promoting blood circulation to remove blood stasis, the function of sharp gas analgesic.
Common St.Paulswort Herb：Bitter, it is cold in nature.Return liver, spleen, kidney channel.Wind-damp dispelling, relieving rigidity of muscles and joints.
Bi Collettii：Bitter, it is mild-natured.Return kidney, stomach.Dampness removing removes turbid, wind expelling stagnation removing.
Soil unit：Taste is salty, cold in nature；It is slightly poisonous.Return liver warp.Energy broken stasis of blood blood, continuous muscles and bones.
Semen brassicae：It is acrid flavour, peppery, it is warm-natured.Return lung passes through.Warm lung slit phlegm profit gas, dissipating bind are removed obstruction in channels to relieve pain.
Smilax：It is sweet, light, it is mild-natured.Return liver, stomach.Have removing toxic substances, dehumidify, it is easing joint movement the effect of.
Honeycomb：It is sweet, it is mild-natured.Return stomach.Detoxicating and destroying parasites, wind-expelling pain-stopping.
Levisticum：Acrid flavour, hardship, slightly warm in nature.Return kidney, bladder warp.Dispelling wind and eliminating dampness, arthritis analgesic.
The root of herbaceous peony：Cold nature, bitter, acid.Return liver, the spleen channel.Nourishing blood and liver, relieved pain in delaying, hold back cloudy receipts sweat.
The wind-weed：Bitter, it is cold in nature.Return lung, stomach, kidney channel.Clearing heat-fire, nourishing Yin and moistening dryness.
Cucumber：It is sweet, it is cool in nature, it is nontoxic.Returns spleen, stomach, large intestine channel.Reunion of fractured tendons and bones, wind-dispelling, dissolving phlegm, replenish the calcium.
Flax benevolence：It is sweet, it is mild-natured.Return lung, spleen, liver and kidney channel.Moisturize laxation, nourishing the liver and kidney.
Radix glycyrrhizae：It is sweet, it is mild-natured.Returns spleen, stomach.Invigorate the spleen and benefit qi, nourishing heart moistening lung, purging intense heat and detonicating, relieving spasm to stop pain, reconcile all
Medicine.
The Chinese medicine preparation of the present invention, 17 taste Chinese medicine used, can conveniently buy, cost is cheap, preparation method in pharmacy
Simply, manufactured Chinese medicine preparation toxic side effect is small, and fast, easily absorption, short treating period, cure rate height are absorbed in alimentary canal.Flavour of a drug
Though more, prescription is rigorous, and monarch, compatibility is proper, and hit the interpretation of the cause, onset and process of an illness.It is clinically used for treating osteoarthritis, is reduced or avoided
Apply caused by Western medicine non-steroid anti-inflammatory drug, regulation Bone m etabolism medicine and glucocorticoid, be reduced or avoided to greatest extent
Caused toxicity in therapeutic process.Rhizome of davallia work(is apt to The strong bone of kidney tonifying, continues and hinders pain relieving in side.Therefore it is usually used in lumbago due to the kidney deficiency, fall
Wink and frustrate, injured bone, Hiccough and deaf, tooth mobility.Teasel has splendid promoting circulation of blood detumescence, reunion of fractured tendons and bones, filling liver kidney, strong
Waist and knee effect, therefore be apt to control aching pain in waist and back, podomere Impotence numbness, fall and flutter wound, damage muscle folding bone.The taste medicine of the above two is to senile caused by liver and kidney deficiency
Caused lumbocrural pain has good therapeutic action, therefore is monarch drug in a prescription altogether.Corydalis tuber, Soil unit, Common St.Paulswort Herbs, semen brassicae, honeycomb, levisticum,
Bi Collettii, smilax, cucumber son, above-mentioned 9 taste Chinese medicine have concurrently dispelling wind and eliminating dampness, promoting blood circulation, remove obstruction in channels to relieve pain, filling liver kidney, strengthening the bones and muscles it
Effect, reinforcement and supplementary function are played to the therapeutic effect of the rhizome of davallia and teasel, therefore are ministerial drug altogether.The Radix Astragali, the red sage root, the wind-weed,
This 4 taste medicine of flax benevolence, possesses nourishing qi and blood, clear up and discharge interior hot, nourishing liver and kidney effect, the mainly trouble based on knee osteoarthritis
Person is mostly person in middle and old age, and qi and blood is decayed more at an early age, therefore applies the Radix Astragali, the red sage root to carry out nourishing qi and blood, especially cold suitable for insufficiency of vital energy and blood
People.Flax benevolence tonifies the liver and kidney essence and blood, and can relax bowel.Heat in the wind-weed is kind clear, for this be using corrigent meaning, prevent many pungent
Warm fragrant dry agent gas consumption impairment of yin, and have good antipyretic effect for the patient of heating.So above-mentioned 4 taste medicine is adjutant altogether.In vain
Chinese herbaceous peony, the taste medicine of licorice two, i.e. peony and licorice decoction, two medicines share, sour sweet and property is cooler, have the work(of good relieving spasm to stop pain.
Peony and licorice decoction is traditional Chinese medical science classical prescription, and treating painful swelling of joints for thousands of years has significant clinical efficacy.By peony and licorice decoction application
Analgesic effect is played in the full side of this cooperation, directly mitigates patient suffering, with to make medicine.
For full square degree, actually it is conceived to filling liver kidney, strengthening the bones and muscles, lively atmosphere blood, the pain that relieves the pain angle cube.Tonifying liver
Kidney, strengthening the bones and muscles be for Patients with Knee Osteoarthritis be mostly the elderly, liver kidney essense blood day degradation it is few, muscles and bones increasingly lose it is foster in moistening,
There is the mechanism of not Rong Ze pains；And lively atmosphere blood is then applied to reality pain caused by blockage of phlegm and blood stasis, i.e. not general rule pain mechanism.This
Outside, cucumber sub (smashing to pieces) and flax benevolence are two kinds of specific drugs for needing especially to explain.Cucumber is synthetism zhuanggu among the people and benefit
The optimal secret recipe of calcium, to the disease of the internal organs such as osteoporosis, legs and feet cramp, rheumatism, arthritis, cervical spondylopathy and liver, stomach, spleen, lung
Disease has the function of resuming treatment with health care.Yellow melon seeds powder can adjust " five consumptive diseases " of people, " seven kinds of impairments ", to long-term internal lesion caused by overexertion and sclerotin injury
And caput femoris necrosis has the function of recovering and treat, and excessively has the function that can be regained one's strength rapidly to human-body fatigue.And there is defaecation
The effect of ease constipation treats constipation.The effect of on compatibility after flax benevolence, can be more preferably.
The Chinese medicine preparation of the present invention, cures mainly knee osteoarthritis.It is oral during treatment, when oral, preferably fluid temperature is heated
To 37 DEG C.One portion per day, one 600ml, takes at twice, and six are a course for the treatment of.General 2~4 courses for the treatment of can obtain notable treatment
Effect.
Embodiment
With reference to embodiment, the present invention is further illustrated.
Embodiment 1 prepares a kind of Chinese medicine preparation for treating knee osteoarthritis
It is formulated and is：30 grams of the rhizome of davallia, 45 grams of the root of herbaceous peony, 12 grams of radix glycyrrhizae, 18 grams of semen brassicae, 30 grams of the Radix Astragali, 12 grams of honeycomb, levisticum
40 grams, 20 grams of teasel, 30 grams of the red sage root, 60 grams of Ke, Common St.Paulswort Herbs, 40 grams of the, Bi Collettiis of corydalis tuber 20,6 grams of Soil unit, 30 grams of smilax, cucumber
30 grams of sub (smashing to pieces), 30 grams of flax benevolence (this is one dosage).
Preparation method is：Preceding each bulk drug of 15 taste is taken, is immersed together in 2000 milliliters of water, is soaked 120 minutes, then slow fire
Decoct 30 minutes, obtain about 300 milliliters of decoction.Afterwards boil for second time, add cold water appropriate, after being cooked by slow fire 20 minutes,
About 300 milliliters of decoction is poured out again.Decoct twice and there are 600 milliliters of decoctions.Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of medicines
In liquid, decoction is obtained, as treats the Chinese medicine preparation of osteoarthritis.
It is oral during treatment, fluid temperature is heated to 37 DEG C.One portion per day, take at twice, about 300 milliliters every time, 6
For a course for the treatment of.
Embodiment 2 prepares a kind of Chinese medicine preparation for treating knee osteoarthritis
It is formulated and is：30 grams of the rhizome of davallia, 60 grams of the root of herbaceous peony, 15 grams of radix glycyrrhizae, 18 grams of semen brassicae, 30 grams of the Radix Astragali, 12 grams of honeycomb, levisticum
40 grams, 20 grams of teasel, 30 grams of the red sage root, 60 grams of Ke, Common St.Paulswort Herbs, 40 grams of the, Bi Collettiis of corydalis tuber 20,30 grams of smilax, 6 grams of Soil unit, the wind-weed
9th, 30 grams of cucumber sub (smashing to pieces), 30 grams of flax benevolence.
Preparation method is：Preceding each bulk drug of 16 taste is taken, is immersed together in 2000 milliliters of water, is soaked 120 minutes, then slow fire
Decoct 30 minutes, obtain about 300 milliliters of decoction.Afterwards boil for second time, add cold water appropriate, after being cooked by slow fire 20 minutes,
About 300 milliliters of decoction is poured out again.Decoct twice and there are 600 milliliters of decoctions.Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of medicines
In liquid, decoction is obtained, as treats the Chinese medicine preparation of osteoarthritis.
Embodiment 3 prepares a kind of Chinese medicine preparation for treating knee osteoarthritis
It is formulated and is：30 grams of the rhizome of davallia, 60 grams of the root of herbaceous peony, 15 grams of radix glycyrrhizae, 15 grams of semen brassicae, 24 grams of the Radix Astragali, 9 grams of honeycomb, levisticum
40 grams, 20 grams of teasel, 30 grams of the red sage root, 60 grams of Ke, Common St.Paulswort Herbs, 40 grams of the, Bi Collettiis of corydalis tuber 20,30 grams of smilax, cucumber it is sub (smashing to pieces)
30 grams, 30 grams of flax benevolence.
Preparation method is：Preceding each bulk drug of 14 taste is taken, is immersed together in 2000 milliliters of water, is soaked 120 minutes, then slow fire
Decoct 30 minutes, obtain about 300 milliliters of decoction.Afterwards boil for second time, add cold water appropriate, after being cooked by slow fire 20 minutes,
About 300 milliliters of decoction is poured out again.Decoct twice and there are 600 milliliters of decoctions.Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of medicines
In liquid, decoction is obtained, as treats the Chinese medicine preparation of osteoarthritis.
Embodiment 4 prepares a kind of Chinese medicine preparation for treating knee osteoarthritis
It is formulated and is：30 grams of the rhizome of davallia, 45 grams of the root of herbaceous peony, 15 grams of radix glycyrrhizae, 18 grams of semen brassicae, 30 grams of the Radix Astragali, 12 grams of honeycomb, levisticum
40 grams, 20 grams of teasel, 20 grams of the red sage root, 45 grams of Ke, Common St.Paulswort Herbs, 30 grams of the, Bi Collettiis of corydalis tuber 20,6 grams of Soil unit, 9 grams of the wind-weed, smilax
30 grams, 30 grams of cucumber sub (smashing to pieces), 30 grams of flax benevolence.
Preparation method is：Preceding each bulk drug of 16 taste is taken, is immersed together in 2000 milliliters of water, is soaked 120 minutes, then slow fire
Decoct 30 minutes, obtain about 300 milliliters of decoction.Afterwards boil for second time, add cold water appropriate, after being cooked by slow fire 20 minutes,
About 300 milliliters of decoction is poured out again.Decoct twice and there are 600 milliliters of decoctions.Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of medicines
In liquid, decoction is obtained, as treats the Chinese medicine preparation of osteoarthritis.
Embodiment 5 prepares a kind of Chinese medicine preparation for treating knee osteoarthritis
It is formulated and is：20 grams of the rhizome of davallia, 45 grams of the root of herbaceous peony, 15 grams of radix glycyrrhizae, 15 grams of semen brassicae, 30 grams of the Radix Astragali, 12 grams of honeycomb, levisticum
40 grams, 20 grams of teasel, 30 grams of the red sage root, 60 grams of Ke, Common St.Paulswort Herbs, 30 grams of the, Bi Collettiis of corydalis tuber 20,6 grams of Soil unit, 10 grams of the wind-weed, smilax
30 grams, 30 grams of cucumber sub (smashing to pieces), 30 grams of flax benevolence.
Preparation method is：Preceding each bulk drug of 16 taste is taken, is immersed together in 2000 milliliters of water, is soaked 120 minutes, then slow fire
Decoct 30 minutes, obtain about 300 milliliters of decoction.Afterwards boil for second time, add cold water appropriate, after being cooked by slow fire 20 minutes,
About 300 milliliters of decoction is poured out again.Decoct twice and there are 600 milliliters of decoctions.Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of medicines
In liquid, decoction is obtained, as treats the Chinese medicine preparation of osteoarthritis.
Embodiment 6 prepares a kind of Chinese medicine preparation for treating knee osteoarthritis
It is formulated and is：30 grams of the rhizome of davallia, 60 grams of the root of herbaceous peony, 15 grams of radix glycyrrhizae, 18 grams of semen brassicae, 30 grams of the Radix Astragali, 12 grams of honeycomb, levisticum
40 grams, 20 grams of teasel, 30 grams of the red sage root, 50 grams of Ke, Common St.Paulswort Herbs, 40 grams of the, Bi Collettiis of corydalis tuber 10,9 grams of Soil unit, 9 grams of the wind-weed, smilax
20 grams, 30 grams of cucumber sub (smashing to pieces), 30 grams of flax benevolence.
Preparation method is：Preceding each bulk drug of 16 taste is taken, is immersed together in 2000 milliliters of water, is soaked 120 minutes, then slow fire
Decoct 30 minutes, obtain about 300 milliliters of decoction.Afterwards boil for second time, add cold water appropriate, after being cooked by slow fire 20 minutes,
About 300 milliliters of decoction is poured out again.Decoct twice and there are 600 milliliters of decoctions.Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of medicines
In liquid, decoction is obtained, as treats the Chinese medicine preparation of osteoarthritis.
Embodiment 7 prepares a kind of Chinese medicine preparation for treating knee osteoarthritis
It is formulated and is：20 grams of the rhizome of davallia, 50 grams of the root of herbaceous peony, 15 grams of radix glycyrrhizae, 18 grams of semen brassicae, 20 grams of the Radix Astragali, 10 grams of honeycomb, levisticum
40 grams, 20 grams of teasel, 30 grams of the red sage root, 50 grams of Ke, Common St.Paulswort Herbs, 30 grams of the, Bi Collettiis of corydalis tuber 20,6 grams of Soil unit, 30 grams of smilax, cucumber
30 grams of sub (smashing to pieces), 30 grams of flax benevolence.
Preparation method is：Preceding each bulk drug of 15 taste is taken, is immersed together in 2000 milliliters of water, is soaked 120 minutes, then slow fire
Decoct 30 minutes, obtain about 300 milliliters of decoction.Afterwards boil for second time, add cold water appropriate, after being cooked by slow fire 20 minutes,
About 300 milliliters of decoction is poured out again.Decoct twice and there are 600 milliliters of decoctions.Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of medicines
In liquid, decoction is obtained, as treats the Chinese medicine preparation of osteoarthritis.
Clinical data：
Patient data：66 knee osteoarthritis patients, Sex distribution are shown in Table 1.
Gender's ratio of 1 66 knee osteoarthritis patients of table
| Sex | Man | Female |
| Number of cases | 26 | 40 |
| Percentage | 39.39% | 60.61% |
66 knee osteoarthritis patients, age distribution are shown in Table 2.
The range of age of 2 66 knee osteoarthritis patients of table
| Age (year) | ≤50 | ≤60 | ≤70 | ＞ 70 |
| Number of cases | 14 | 23 | 16 | 13 |
| Percentage | 21.21% | 34.85% | 24.24% | 19.70% |
Therapeutic modality：All patients take the Chinese medicine preparation of the preparation of embodiment 2, and when taking, fluid temperature is heated to
37 DEG C oral.Daily 1 dose, take at twice, about 300 milliliters every time, 6 are 1 course for the treatment of.I.e. withdrawal after effective.
The standard of curative effect evaluation：With reference to version in 2002《New Chinese medicine guideline of clinical investigations》Clinical efficacy evaluation criteria：
It is 1. effective：The symptom eliminates such as pain, joint motion are unrestricted；It is 2. effective：The symptoms such as pain substantially eliminate, joint motion slightly by
Limit；It is 3. invalid：The symptoms such as pain are not improved with joint motion.It is shown in Table 3 in detail.
Situation table before and after 3 66 knee osteoarthritis Case treatments of table
Treatment results：As shown in table 4, table 5.
4 66 knee osteoarthritis patient's curative effect tables of table
| It is effective | Effectively | It is invalid | |
| Number of cases | 48 | 14 | 4 |
| Percentage | 72.73% | 21.21% | 6.06% |
5 66 knee osteoarthritis patient's course for the treatment of tables of table
| Treat number of days | 5~7 days | 8~14 days | 15~21 days | 22~28 days |
| Number of cases | 3 | 22 | 26 | 15 |
| Percentage | 4.55% | 33.33% | 39.39% | 22.73% |
Clinical practice：
This research observes from November, 2012 in October, 2014 patient 132 totally.It is divided into two groups, wherein test group 66
Example, control group 66.
1 group technology：132 patients are divided into test group 66, control group 66.
2 therapeutic modalities：
Test group：All patients take the Chinese medicine preparation of the preparation of embodiment 2.When taking, fluid temperature is heated to 37
It is DEG C oral.Daily 1 dose, take at twice, about 300 milliliters every time, it is 1 course for the treatment of to be used in conjunction 6 days.I.e. withdrawal after effective.
Control group：Oral C14H10Cl2NNaO2 (trade name：Wear sweet smell), 1~2 times/day of 75mg.6 days are the 1 observation course for the treatment of.
3 observational techniques：
3.1 inclusion criteria：Meet modern medicine " knee osteoarthritis " diagnostic criteria, and meet the traditional Chinese medical science " heumatism ", " bi Zheng "
Diagnosis, the patient of dialectical category " caused by liver and kidney deficiency, the tendon and vessel stasis of blood are stagnant ".
3.2 data collection：Patient is paid a return visit, change of illness state is understood, patient medication onset time is counted, done
Go out to compare, and patient's four methods of diagnosis situation, symptom integral are counted with reference to Evaluation of Synthetic Effect of Holistic standard, draw comprehensive therapeutic effect knot
By being compared.
4 observation index：
Every TCM symptom score changes such as pretherapy and post-treatment patient articular's pain, morning stiffness, activity be unfavorable.
5 statistical procedures：
5.1 two groups of patient disease total effectses the results are shown in Table 6
6 two groups of patient disease total effectses of table compare
As can be seen from Table 6, test group total effective rate is 93.94%, and control group total effective rate is 98.48%, through sum of ranks
Examine, two groups of total effective rates compare that there was no significant difference (P>0.05).
5.2 two groups of patient's tcm syndrome curative effects are relatively shown in Table 7
7 two groups of patient's tcm syndrome curative effects of table compare
Found out by table 7, two groups of patient's tcm syndrome curative effects compare, and test group total effective rate is 93.94%, and control group always has
Efficiency is 98.48%, through rank test, two groups of tcm syndrome curative effects compare that there was no significant difference (P>0.05).
5.3 adverse reaction：
Test group is shown in 3 laxativeness, does not give specially treated, all recovers normal defecation after drug withdrawal of recovering.Control group has 12
There is gastric discomfort discomfort in example patient.
6 treatment results：
By the medication efficacy analysis to test group and control group, we conclude that, using the Chinese medicine preparation of the present invention
Knee osteoarthritis is treated, night bed is bitterly or uncomfortable, walking pain or discomfort, the symptoms such as knee articulation is limited, works more
Rapidly, and effective percentage, obvious effective rate are poor unlike western medicine result, it is often more important that the side effect after medication is seldom, so can fill
The effect of Chinese medicine exquisite compatibility advantage is revealed in split.
Model case Lee, female, 64 years old, retired employees.Because " double knee joint pain recurrent exerbation 1 year, aggravating with both hands the
3 nearly articulations digitorum manus pain 2 months " were examined on July 12nd, 2014.1 year cause of patient is climbed the mountain and tired too causes right knee joint to occur
Pain, walking is unfavorable, and pain is alleviated substantially after rest first quarter moon.There is left knee joint also pain, activity because jumping square dance again afterwards
Postemphasis, taken a turn for the better after rest.Gone to a doctor in 2013 Nian9Yue Fenlai our hospital Orthopaedics Clinics, row double knee joint X-ray shows between double knee joint
Gap narrows, and double knee spinous process of tibia come to a point, and right knee shin bone inner edge has spur to be formed, and is diagnosed as knee osteoarthritis.Orthopedist gives
Oral aulin 0.1Qd, dredging collateral open the 3 Bid treatments of numbness piece, while advise it to reduce knee articulation.After medication first quarter moon, symptom
Slightly subtract.It can still feel that knee joint has mild pain during walking.Gonalgia aggravates during rainy days.After in May, 2014 is because of sweating
Laundry contact cold water causes the 3rd nearly articulations digitorum manus of both hands pain occur, examines then.It is existing symptoms include：Double knee joint pain is obvious, after activity
Aggravate, mitigate after rest, the 3rd nearly articulations digitorum manus pain of both hands, both hands stiff sense when from morning, can alleviate after several minutes of activity.Joint
Usually fear of wind is cold, and rainy days, pain aggravated.Receive dormancy can, two just adjust.Tongue nature is light red, and tongue is thin white, small and wiry pulse.Have a medical check-up：The bodily form is fat,
Double kneecap rubbing feelings (+), the nearly articulations digitorum manus of both hands middle finger is without swelling, tenderness (+).Look into same day erythrocyte sedimentation rate 21mm/h.Doctor trained in Western medicine diagnoses：Kneecap closes
Section is scorching, tcm diagnosis：Heumatism (caused by liver and kidney deficiency, the tendon and vessel stasis of blood are stagnant).Control with filling liver kidney, strengthening the bones and muscles, qi and activate blood circulation, dispelling wind and eliminating dampness, lead to
Network relieves pain.Treated by the medicine of embodiment 2, during treatment, orally, fluid temperature is heated to 37 DEG C.One portion per day, it is divided to two
Secondary to take, about 300 milliliters every time, 6 are a course for the treatment of.During medication, it is advised to avoid heavy burden and activity too many.Successively take medicine 18 altogether
Agent, all arthralgias are alleviated.
Claims (4)
1. a kind of Chinese medicine preparation for treating knee osteoarthritis, it is characterised in that be made of following bulk drug：The rhizome of davallia 20~
30 grams, 45~60 grams of the root of herbaceous peony, 10~15 grams of radix glycyrrhizae, 12~18 grams of semen brassicae, 15~30 grams of the Radix Astragali, 9~12 grams of honeycomb, levisticum 30
~40 grams, 10~20 grams of teasel, 15~30 grams of the red sage root, 45~60 grams of Ke, Common St.Paulswort Herbs, 30~40 grams of the, Bi Collettiis of corydalis tuber 10~20,
20~30 grams of smilax, 20~30 grams of cucumber, 20~30 grams of flax benevolence, 6~9 grams of Soil unit, 9~12 grams of the wind-weed；
The Chinese medicine preparation is prepared by the following method to obtain：In addition to flax benevolence, each bulk drug is taken, is immersed in the water together, with
Submergence is defined, and soaks 90~150 minutes, is then cooked by slow fire 20~30 minutes, pours out 300 milliliters of decoction；Second is carried out afterwards
All over boiling, add cold water appropriate, after being cooked by slow fire 20~30 minutes, then pour out 300 milliliters of decoction；Decoct twice and there are 600 millis
Hydrargyrum oxydatum crudum liquid；Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters of decoctions, obtain decoction, as treat the Chinese medicine system of knee osteoarthritis
Agent.
2. a kind of Chinese medicine preparation for treating knee osteoarthritis according to claim 1, it is characterised in that be by following raw material
Made of medicine：30 grams of the rhizome of davallia, 60 grams of the root of herbaceous peony, 15 grams of radix glycyrrhizae, 18 grams of semen brassicae, 30 grams of the Radix Astragali, 12 grams of honeycomb, 40 grams of levisticum,
20 grams of teasel, 30 grams of the red sage root, 60 grams of Ke, Common St.Paulswort Herbs, 40 grams of the, Bi Collettiis of corydalis tuber 20,30 grams of smilax, cucumber sub 30 grams, flax benevolence
30 grams, 6 grams of Soil unit, 9 grams of the wind-weed.
A kind of 3. preparation method of Chinese medicine preparation for treating knee osteoarthritis described in claim 1 or 2, it is characterised in that step
Suddenly it is：In addition to flax benevolence, each bulk drug is taken, is immersed in the water together, be defined by submergence, soaked 90~150 minutes, be then cooked by slow fire
Boil 20~30 minutes, pour out 300 milliliters of decoction；Afterwards boil for second time, add cold water appropriate, to be cooked by slow fire 20~30 points
Zhong Hou, then pour out 300 milliliters of decoction；Decoct twice and there are 600 milliliters of decoctions；Take flax benevolence to smash to pieces or grind, be sprinkled into 600 milliliters
In decoction, decoction is obtained, as treats the Chinese medicine preparation of knee osteoarthritis.
4. the preparation method of the Chinese medicine preparation for the treatment of knee osteoarthritis as claimed in claim 3, it is characterised in that the immersion
Basis of time season is different and different, and summer is 90~120 minutes；Other seasons are 120~150 minutes.
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Non-Patent Citations (3)
| Title |
|---|
| 中医药治疗退行性膝关节骨关节炎87例;黄进等;《现代中西医结合杂志》;20020531;第11卷(第9期);第837-838页，尤其是第837页右栏最后一段 * |
| 中药内服加外熏洗治疗类风湿关节炎的研究;潘华等;《光明中医》;20110630;第26卷(第6期);第1132-1133页，尤其是第1133页左栏第2.3.2节 * |
| 膝关节骨性关节炎;唐汉中医药网;《http://book.th55.cn/a/201206/8154.html》;20120627;第1-3页，尤其是第3页3.张方建诊治经验 * |
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