CN104524426A - Traditional Chinese medicine for treating cerebral hemorrhage - Google Patents
Traditional Chinese medicine for treating cerebral hemorrhage Download PDFInfo
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- CN104524426A CN104524426A CN201410730489.8A CN201410730489A CN104524426A CN 104524426 A CN104524426 A CN 104524426A CN 201410730489 A CN201410730489 A CN 201410730489A CN 104524426 A CN104524426 A CN 104524426A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to the field of pharmaceutical formulation, specifically to a traditional Chinese medicine for treating cerebral hemorrhage. The traditional Chinese medicine is characterized by being prepared from the following medicinal raw materials, by weight, 5-9% of cassia seed, 4-7% of ligustrum lucidum, 4-7% of stigma croci, 4-8% of Radix Ceratostigmae, 5-8% of rhizoma nardostachyos, 6-9% of sea-buckthorn, 6-9% of Renanthera, 7-9% of Radix Ceratostigmae, 6-9% of prunella vulgaris, 2-5% of sharpleaf galangal fruit, 6-9% of erycibe obtusifolia benth, 2-5% of piper wallichii, 4-6% of peganum harmala, 2-4% of roud cardamon seed, 4-6% of curcuma tuber and 2-4% of radix bupleuri. The above 17 medicinal raw materials are immersed in water; and after decoction, slag is removed to obtain a filtrate. The traditional Chinese medicine provided by the invention has advantages of remarkable curative effect, low cost and no toxic or side-effect.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine for the treatment of cerebral hemorrhage.
Background technology
As everyone knows, cerebral hemorrhage is also called cerebral hemorrhage, is due to non-traumatic the breaking of cerebral artery vessel, and blood enters a kind of acute illness occurred in brain essence, more common in acute cerebrovascular disease.Primary disease main clinical manifestation is unexpected disturbance of consciousness and quadriplegia, and the hyperpietic of usual about 50 years old falls ill at most, and male is more than women.The modal cause of disease is hypertensive cerebral hemorrhage, is taking into account on the basis of other inducements, is that hypertension must be controlled effectively, effectively could avoids the generation of hypertensive cerebral hemorrhage.On the basis of hypertension long term, any generation can brought out factor that blood pressure short-term increases and can cause hypertensive cerebral hemorrhage.Nowadays, cerebral hemorrhage has become an emergency case serious symptom comparatively extensively occurred, and China is annual because the patient of death from cerebral hemorrhage accounts for about 20% of whole disease death.The treatment of cerebral hemorrhage, conventional has Drug therapy and operative treatment, and medication effect is limited, and easily brings the side effect such as drug dependence, liver damage to patient.And operative treatment has a big risk, costly, postoperative easy recurrence, not easily selects.
Summary of the invention
Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides a kind of Chinese medicine for the treatment of cerebral hemorrhage evident in efficacy, with low cost.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of cerebral hemorrhage, it is characterized in that being made up of the crude drug of following percentage by weight: Semen Cassiae 5 ~ 9%, Radix Rhodiolae 4 ~ 7%, Fructus Ligustri Lucidi 4 ~ 8%, Stigma Croci 4 ~ 7%, Radix ceratostigmatis willemottiani 4 ~ 8%, Radix Et Rhizoma Nardostachyos 5 ~ 8%, Fructus Hippophae 6 ~ 9%, Herba Renantherae coccineae 6 ~ 9%, Radix ceratostigmatis willemottiani 7 ~ 9%, Spica Prunellae 6 ~ 9%, Fructus Alpiniae Oxyphyllae 2 ~ 5%, Caulis Erycibes 6 ~ 9%, Caulis et Folium piperis 2 ~ 5%, Herba pegani harmalae 4 ~ 6%, roud cardamon seed 2 ~ 4%, Radix Curcumae 4 ~ 6%, Radix Bupleuri 2 ~ 4%, above-mentioned 17 kinds of crude drug are soaked in water, to remove slag after decocting to obtain filtrate.
The invention has the beneficial effects as follows, the advantage such as evident in efficacy, with low cost, without any side effects.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Semen Cassiae, Radix Rhodiolae, Fructus Ligustri Lucidi, Stigma Croci, Radix ceratostigmatis willemottiani, Radix Et Rhizoma Nardostachyos, Fructus Hippophae, Herba Renantherae coccineae, Radix ceratostigmatis willemottiani, Spica Prunellae, Fructus Alpiniae Oxyphyllae, Caulis Erycibes, Caulis et Folium piperis, Herba pegani harmalae, roud cardamon seed, Radix Curcumae, Radix Bupleuri is adopted to be that raw material is prepared from.The every pair of its component (% by weight) is Semen Cassiae 7.5, Radix Rhodiolae 6.1, Fructus Ligustri Lucidi 5.9, Stigma Croci 6.1, Radix ceratostigmatis willemottiani 5.5, Radix Et Rhizoma Nardostachyos 7.1, Fructus Hippophae 7.8, Herba Renantherae coccineae 7.8, Radix ceratostigmatis willemottiani 8.1, Spica Prunellae 7.7, Fructus Alpiniae Oxyphyllae 3.2, Caulis Erycibes 7.7, Caulis et Folium piperis 2.9, Herba pegani harmalae 5.5, roud cardamon seed 3.5, Radix Curcumae 4.7, Radix Bupleuri 2.9.Get above-mentioned 17 taste raw materials, gross weight is 176 grams, add water 800 ~ 900 milliliters and at room temperature soak 5 ~ 6 hours, slow fire decocted to 60 ~ 80 minutes, filtrate about 150 milliliters of removing slag to obtain, and medicinal residues add water 200 ~ 300ml again, decoct 20 ~ 30 minutes, to remove slag to obtain filtrate 50 ~ 70 milliliters, altogether the medicine juice of about 200 ~ 220 milliliters, i.e. obtained decoction of the present invention.Load in sterile glass vials, seal bottle cap is for subsequent use, and every day 1 dose point 2 times is oral, sooner or later respectively once, and each (medicine) being taken before meal 100 ~ 110 milliliters.
Semen Cassiae loosening bowel to relieve constipation of the present invention, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, reducing blood pressure and blood fat; Radix Rhodiolae has QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling; Fructus Ligustri Lucidi is used for coronary heart disease, hyperlipemia, hypertension, chronic hepatitis; Stigma Croci has blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, effect of resolving stagnation for tranquilization.For amenorrhea, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad; Radix ceratostigmatis willemottiani promoting blood circulation and stopping pain, blood stasis dispersing and fresh blood promoting; Functions dispelling wind and clearing away cold, removing dampness is subsided a swelling, relaxing muscles and tendons and activating QI and blood in the collateral.For anemofrigid-damp arthralgia, muscle arteries and veins contracture pain carbuncle; Effect of Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, activating spleen and strengthening stomach, contributes to treating abdominal distention, anorexia; Fructus Hippophae has effect of relieving cough and resolving phlegm, invigorating the stomach and promoting digestion, promoting blood circulation to remove blood stasis.Can reduce cholesterol, allevating angina pectoris shows effect, and prevents and treats the effect of coronary atherosclerotic heart disease in addition; The synthetism of Herba Renantherae coccineae dissipating blood stasis, for fracture; Spica Prunellae has the effect of improving eyesight of relieving inflammation or internal heat, and can control conjunctival congestion and swelling pain, headache etc.; Fructus Alpiniae Oxyphyllae warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air stomachache, invasion by pathogenic cold is vomited and diarrhoea, many salivas; Caulis Erycibes expelling wind and removing dampness, reducing swelling and alleviating pain.For rheumatic arthralgia, hemiplegia, tumbling and swelling; Radix ceratostigmatis willemottiani promoting blood circulation and stopping pain, blood stasis dispersing and fresh blood promoting; Caulis et Folium piperis wind-damp dispelling, the meridian dredging, strong waist foot, pain relieving cough-relieving; Herba pegani harmalae has relieving cough and asthma, wind-damp dispelling, and detumescence poison is to effect; Roud cardamon seed has regulating the flow of QI to ease the stomach, dry cold-damp, effect of alcoholic intoxication.Can to treat for stomachache the disease such as abdominal distention, eructation regurgitation; Radix Curcumae has the use of regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire; Radix Bupleuri has reconciling superficies and interior, effect of soothing the liver yang invigorating.
The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.Its processing technique is identical with embodiment 1.
| Embodiment | Semen Cassiae | Radix Rhodiolae | Fructus Ligustri Lucidi | Stigma Croci | Radix ceratostigmatis willemottiani | Radix Et Rhizoma Nardostachyos | Fructus Hippophae | Herba Renantherae coccineae | Radix ceratostigmatis willemottiani | Spica Prunellae | Fructus Alpiniae Oxyphyllae | Caulis Erycibes | Caulis et Folium piperis | Herba pegani harmalae | Roud cardamon seed | Radix Curcumae | Radix Bupleuri |
| Two | 9 | 7 | 4 | 7 | 4 | 8 | 6 | 9 | 7 | 9 | 3 | 9 | 2 | 6 | 2 | 6 | 2 |
| Three | 9 | 4 | 8 | 4 | 8 | 5 | 9 | 6 | 9 | 6 | 5 | 6 | 5 | 4 | 4 | 4 | 4 |
| Four | 5 | 6 | 7 | 6 | 5 | 7 | 8 | 8 | 8 | 9 | 2 | 9 | 4 | 5 | 3 | 5 | 3 |
| Five | 8 | 5 | 7 | 5 | 7 | 6 | 7 | 7 | 8 | 7 | 4 | 7 | 3 | 5 | 4 | 6 | 4 |
The clinical trial carried out below in conjunction with my institute is done further the present invention, is described in detail:
1, case selection: adopt Chinese medicine composition of the present invention to treat 96 routine patients with cerebral hemorrhage is altogether the patients with cerebral hemorrhage of being in hospital 1-30 days.Wherein man 56 example, female 40 example; The oldest person 68 years old, age reckling only has 40 years old.In 96 routine patients with cerebral hemorrhage: putamen hemorrhage 1-30CC 42 example; Cerebral lobar hemorrhage 2-30CC 18 example; Pontine hemorrhage 2-30 CC 14 example; Cerebellar hemorrhage 5-30CC 12 example, ventricular hemorrhage 5-25CC 10 example.
2, Therapeutic Method: every day 1 dose point 2 times is oral, and each (medicine) being taken before meal 100-110ml, treats 3 months altogether.Medication checked head CT after 3 months, carried out nervous function damage and improved degree scoring, to observe absorption of hematoma situation and efficacy evaluation.
3, the standard of curative effect evaluation: cure: hemiplegic limb recovers 5 grades, language performance is without difficulty, and life can be taken care of oneself.Effective: language performance is still not exclusively fluent, Myodynamia recovery 3-4 level, life can be taken care of oneself or half self-care.Effective: vital sign is normal; Hemiplegic limb takes a turn for the better, Myodynamia recovery 2-3 level, and language performance is unfluent, can't take care of oneself.Invalid: to die from complication, clinical death.
4, therapeutic effect: after 3 months, in the 96 routine patients with cerebral hemorrhage that pharmaceutical composition of the present invention is treated, cures 86 examples, accounts for 89.6%; Effective 7 examples, account for 7.3%; Effective 3 examples, account for 3.1%.Total effective rate 100%.Result shows, Chinese medicine composition of the present invention has extremely significant curative effect to treatment patients with cerebral hemorrhage.
Model case:
Soup, female, 57 years old, has hypertension history, go out morning exercises time fall down, complete aphasia, but Consciousness, can eat into a small amount of food, left hand can not activity freely, and left lower extremity is numb, and bed can not be stood up, vexed, mental confusion, dizzy, frequent micturition, light red tongue, white and thin fur, on inspection putamen hemorrhage 25cc.Take Chinese medicine composition of the present invention after 1 month, brain hematoma major part disappears, language function recovers completely, can out-of-bed activity, following the service Chinese medicine composition of the present invention 1 month, brain hematoma disappears completely, can not by any auxiliary, freedom of movement, symptom disappears completely, follow up a case by regular visits to 1 year without recurrence, without bad sequela.
Hu, man, 67 years old, patient have hypertension history, patient because of my old man dead, excited, burst cerebral hemorrhage, syncope, hands of dehiscing spreads, eye close, the enuresis.Putamen hemorrhage is about 30CC on inspection.Gavage Chinese medicine composition of the present invention after 3 days, recover swallow, after 7 days, language function recovers, but aphasia, continue to take pharmaceutical composition of the present invention after 3 weeks, speech is smooth, can stand up and sit up; Following the service Chinese medicine composition of the present invention 1 month, all transference cures, follow up a case by regular visits to 1 year, and patient body is healthy, no sequel.
Chen, female, 46 years old, unexpected dizzy, headache during working, asophia, right side quadriplegia, irregular breathing, muscular strength went down, and is pontine hemorrhage through examination in hospital, hemorrhage about 20CC.Take Chinese medicine composition of the present invention after 1 week, extensive language function recovers, and speech is fluent, continues to take pharmaceutical composition of the present invention after 3 weeks, can by auxiliary implement out-of-bed activity, following the service Chinese medicine composition of the present invention 1 month, all transference cures, follow up a case by regular visits to 1 year, patient body is healthy, no sequel.
Claims (1)
1. treat the Chinese medicine of cerebral hemorrhage for one kind, it is characterized in that being made up of the crude drug of following percentage by weight: Semen Cassiae 5 ~ 9%, Radix Rhodiolae 4 ~ 7%, Fructus Ligustri Lucidi 4 ~ 8%, Stigma Croci 4 ~ 7%, Radix ceratostigmatis willemottiani 4 ~ 8%, Radix Et Rhizoma Nardostachyos 5 ~ 8%, Fructus Hippophae 6 ~ 9%, Herba Renantherae coccineae 6 ~ 9%, Radix ceratostigmatis willemottiani 7 ~ 9%, Spica Prunellae 6 ~ 9%, Fructus Alpiniae Oxyphyllae 2 ~ 5%, Caulis Erycibes 6 ~ 9%, Caulis et Folium piperis 2 ~ 5%, Herba pegani harmalae 4 ~ 6%, roud cardamon seed 2 ~ 4%, Radix Curcumae 4 ~ 6%, Radix Bupleuri 2 ~ 4%, above-mentioned 17 kinds of crude drug are soaked in water, filtrate of removing slag after decocting to obtain.
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| CN201410730489.8A CN104524426A (en) | 2014-12-05 | 2014-12-05 | Traditional Chinese medicine for treating cerebral hemorrhage |
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| CN201410730489.8A CN104524426A (en) | 2014-12-05 | 2014-12-05 | Traditional Chinese medicine for treating cerebral hemorrhage |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456534A (en) * | 2015-12-29 | 2016-04-06 | 青岛昌安达药业有限公司 | Traditional Chinese medicine preparation for treating cerebral hemorrhage |
| CN105535274A (en) * | 2015-12-29 | 2016-05-04 | 青岛昌安达药业有限公司 | Traditional Chinese medicine formula for treating cerebral hemorrhage |
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| JP2003034646A (en) * | 2001-06-29 | 2003-02-07 | Teruhiko Shimoda | 'shin-ei husai gan'-first-aid chinese medicine for treating cerebrovascular disease(cvd) |
| CN101554439A (en) * | 2009-05-12 | 2009-10-14 | 河北金大地房地产开发有限公司 | Traditional Chinese medicine preparation for preventing cerebral arteriosclerosis |
| CN103393941A (en) * | 2013-07-29 | 2013-11-20 | 刘庆华 | Drug for treating cerebral infarction |
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2014
- 2014-12-05 CN CN201410730489.8A patent/CN104524426A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003034646A (en) * | 2001-06-29 | 2003-02-07 | Teruhiko Shimoda | 'shin-ei husai gan'-first-aid chinese medicine for treating cerebrovascular disease(cvd) |
| CN101554439A (en) * | 2009-05-12 | 2009-10-14 | 河北金大地房地产开发有限公司 | Traditional Chinese medicine preparation for preventing cerebral arteriosclerosis |
| CN103393941A (en) * | 2013-07-29 | 2013-11-20 | 刘庆华 | Drug for treating cerebral infarction |
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| 杨晓恒等: "活血化痰清热通腑法为主治疗急性脑出血138例疗效观察", 《中国中医急症》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456534A (en) * | 2015-12-29 | 2016-04-06 | 青岛昌安达药业有限公司 | Traditional Chinese medicine preparation for treating cerebral hemorrhage |
| CN105535274A (en) * | 2015-12-29 | 2016-05-04 | 青岛昌安达药业有限公司 | Traditional Chinese medicine formula for treating cerebral hemorrhage |
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