CN108542963A - A kind of film forming pharmaceutical composition and preparation method thereof of prevention and treatment mastitis for milk cows - Google Patents
A kind of film forming pharmaceutical composition and preparation method thereof of prevention and treatment mastitis for milk cows Download PDFInfo
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- CN108542963A CN108542963A CN201810567891.7A CN201810567891A CN108542963A CN 108542963 A CN108542963 A CN 108542963A CN 201810567891 A CN201810567891 A CN 201810567891A CN 108542963 A CN108542963 A CN 108542963A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Pregnancy & Childbirth (AREA)
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Abstract
A kind of film forming pharmaceutical composition and preparation method thereof of prevention and treatment mastitis for milk cows, belongs to technical field of animal husbandry；The technical problem to be solved is that the film forming pharmaceutical compositions and preparation method thereof of a kind of nontoxic, no drug residue of offer, the prevention and treatment mastitis for milk cows that drug safety, curative effect is fast, cure rate is high；The technical solution used for：0.5 5 parts of propolis, 1.5 2.5 parts of radix bupleuri distillate, 1.5 2.5 parts of cordate houttuynia distillate, 0.5 1 parts of film forming agent, 0.5 1 parts of transdermal agent, 50 65 parts of ethyl alcohol, 30 50 parts of water, wherein film forming agent are NC Nitroncellulose, and transdermal agent is azone, and ethyl alcohol is absolute ethyl alcohol.
Description
Technical field
The present invention relates to a kind of film forming pharmaceutical compositions and preparation method thereof of prevention and treatment mastitis for milk cows, belong to poultry
Animal husbandry cultural technique field.
Background technology
Mammitis, also known as acute mastitis, milk is yellow, milk is swollen, is to become carbuncle swells since hemostasis poison gas is condensed in breast, breast occurs
Firmly, it swells, heat, pain, infected cattle refuses cub sucking or a kind of disease of hand milking, is more common in the cow of postpartum breastfeeding phase, especially
Be lactation period milk cow it is more common.According to statistics, mammitis accounts for the 21%-23% that milk cow always falls ill, and milk amount declines caused by it, disease
Breast is discarded, or even since newborn area suppurates, gangrenous, atrophy is so that permanently lose milking capacity, causes milk cow to be eliminated, give dairy band
Very big loss is carried out.The milk cow being eliminated every year by mammitis accounts for the 9%-10% of total mortality.
The milk cow production in the 21st century, China enters the new stage of rapid development, and broad masses of the people are for breast
And the demand of dairy products is continuously increased, this is in the rapid development for objectively having greatly facilitated China's milk cow production.But it is newborn
The generation of room inflammation, the serious yield and quality for affecting milk cow, causes milk cow to be eliminated too early, culture efficiency is made to reduce, to wide
Big raiser brings huge economic loss.In addition over the course for the treatment of, due to largely using the chemicals such as antibiotic, cause
The generation of antibody-resistant bacterium and various antibiotic residues cause the output of milk and the quality decline of milk, form antibiotic milk, seriously endanger
People's health.And Chinese herbal medicine is mainly using the plant of nature, animal and minerals as raw material, it is pure to be that animal body most easily absorbs
Natural materials, containing there are many biological effective components, and toxic side effect is little, almost noresidue, without drug resistance, it is free from environmental pollution,
There is unique advantage in terms for the treatment of mastitis for milk cows.
Invention content
Overcome the deficiencies in the prior art of the present invention, the technical problem to be solved is that provide nontoxic one kind, no drug residue, medication
Safety；The film forming pharmaceutical composition and preparation method thereof for the prevention and treatment mastitis for milk cows that curative effect is fast, cure rate is high.
In order to solve the above technical problems, the technical solution adopted in the present invention is：A kind of prevention and treatment mastitis for milk cows
Film forming pharmaceutical composition, the group of the composition is divided into：0.5-5 parts of propolis, 1.5-2.5 parts of radix bupleuri distillate, cordate houttuynia distillation
1.5-2.5 parts of liquid, 0.5-1 parts of film forming agent, 0.5-1 parts of transdermal agent, 50-65 parts of ethyl alcohol, 30-50 parts of water.Wherein film forming agent is nitre
Base cellulose, transdermal agent are azone, and ethyl alcohol is absolute ethyl alcohol.
A kind of film forming pharmaceutical composition of preferred prevention and treatment mastitis for milk cows, the group of the composition are divided into：Propolis
0.5 part, 1.5 parts of radix bupleuri distillate, 1.5 parts of cordate houttuynia distillate, 0.5 part of film forming agent, 0.5 part of transdermal agent, 65 parts of ethyl alcohol, water 33
Part.Wherein film forming agent is NC Nitroncellulose, and transdermal agent is azone, and ethyl alcohol is absolute ethyl alcohol.
The preparation method of the film forming pharmaceutical composition of the prevention and treatment mastitis for milk cows is：
A, 0.5-5 parts of propolis is weighed, 35 parts of 80 DEG C of absolute ethyl alcohols is added to dissolve by heating, it is spare；
B, 30 parts of 1.5-2.5 parts of radix bupleuri distillate, 1.5-2.5 parts of cordate houttuynia distillate purifying water dissolutions are weighed, it is spare；
C, 0.5-1 parts plus 30 parts absolute ethyl alcohol dissolvings of film forming agent are weighed, it is spare；
D, the solution obtained by step A, B and C is uniformly mixed, is eventually adding 0.5-1 parts of transdermal agent, 100 is settled to water
Part degree filters to get the pharmaceutical composition.
Compared with prior art the invention has the advantages that.
In prescription of the present invention, the propolis mechanism of action mainly can sterilize, sterilize, sterilize, be antibacterial, and it is only right to solve antibiotic
The defect and unique film forming that single microorganism works have good prosthetic to the breast of damage, and make without secondary
With it is significant to show that propolis has Escherichia coli, staphylococcus aureus for causing mammitis etc. by extracorporeal bacteria inhibitor test
Effect, MIC are very low.
The mechanism of action of radix bupleuri distillate mainly can alleviate rapidly the red, hot, swollen of mammitis, pain symptom.
The mechanism of action of cordate houttuynia distillate is mainly clearing heat and detoxicating, detumescence and apocenosis, to cause mammitis Escherichia coli,
Staphylococcus aureus etc. has obvious action.
The pharmaceutical composition of the treatment mastitis for milk cows of the present invention, category pure Chinese medicinal preparation, nontoxic, no drug residue, green product,
Drug safety；Large-scale application proves that curative effect is fast, cure rate is high, no recurrence.
Specific implementation mode
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of film forming pharmaceutical composition of prevention and treatment mastitis for milk cows, the group of the composition are divided into：0.5 part of propolis, radix bupleuri
1.5 parts of distillate, 1.5 parts of cordate houttuynia distillate, 0.5 part of film forming agent, 0.5 part of transdermal agent, 50 parts of ethyl alcohol, 30 parts of water.
Embodiment 2
A kind of film forming pharmaceutical composition of prevention and treatment mastitis for milk cows, the group of the composition are divided into：5 parts of propolis, radix bupleuri steam
2.5 parts of distillate, 2.5 parts of cordate houttuynia distillate, 1 part of film forming agent, 1 part of transdermal agent, 65 parts of ethyl alcohol, 50 parts of water.
Embodiment 3
A kind of film forming pharmaceutical composition of prevention and treatment mastitis for milk cows, the group of the composition are divided into：2 parts of propolis, radix bupleuri steam
1.8 parts of distillate, 2.2 parts of cordate houttuynia distillate, 0.7 part of film forming agent, 0.6 part of transdermal agent, 60 parts of ethyl alcohol, 40 parts of water.
Embodiment 4
A kind of film forming pharmaceutical composition of prevention and treatment mastitis for milk cows, the group of the composition are divided into：3.2 parts of propolis, radix bupleuri
2.2 parts of distillate, 1.9 parts of cordate houttuynia distillate, 0.7 part of film forming agent, 0.8 part of transdermal agent, 62 parts of ethyl alcohol, 43 parts of water.
Embodiment 5
A kind of film forming pharmaceutical composition of prevention and treatment mastitis for milk cows, the group of the composition are divided into：4.2 parts of propolis, radix bupleuri
2.1 parts of distillate, 1.7 parts of cordate houttuynia distillate, 0.9 part of film forming agent, 0.6 part of transdermal agent, 57 parts of ethyl alcohol, 39 parts of water.
In above example 1-5, the preparation method for preventing and treating the film forming pharmaceutical composition of mastitis for milk cows is：
A, propolis is weighed, ethyl alcohol is added to dissolve by heating, it is spare；
B, radix bupleuri distillate, cordate houttuynia distillate water dissolution are weighed, it is spare；
C, weighing film forming agent adds ethyl alcohol to dissolve, spare；
D, the solution obtained by step A, B and C is uniformly mixed, is eventually adding transdermal agent, scale is settled to water, filtered,
Up to the pharmaceutical composition.
The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit invention,
Claims indicate the scope of the present invention, and above-mentioned explanation does not point out the scope of the present invention, therefore, with the present invention
The comparable meaning and scope of claims in any variation, be regarded as being included within the scope of the claims.
Claims (3)
1. a kind of film forming pharmaceutical composition of prevention and treatment mastitis for milk cows, which is characterized in that the group of the composition is divided into：Bee
0.5-5 parts of glue, 1.5-2.5 parts of radix bupleuri distillate, 1.5-2.5 parts of cordate houttuynia distillate, 0.5-1 parts of film forming agent, transdermal agent 0.5-1
Part, 50-65 parts of ethyl alcohol, 30-50 parts of water.
2. a kind of film forming pharmaceutical composition of prevention and treatment mastitis for milk cows according to claim 1, which is characterized in that
The film forming agent is NC Nitroncellulose, and the transdermal agent is azone, and the ethyl alcohol is absolute ethyl alcohol.
3. special according to a kind of film forming pharmaceutical composition of any prevention and treatment mastitis for milk cows of claims 1 or 2
Sign is that the preparation method of the composition is：
A, 0.5-5 parts of propolis is weighed, 35 parts of 80 DEG C of absolute ethyl alcohols is added to dissolve by heating, it is spare；
B, 30 parts of 1.5-2.5 parts of radix bupleuri distillate, 1.5-2.5 parts of cordate houttuynia distillate purifying water dissolutions are weighed, it is spare；
C, 0.5-1 parts plus 30 parts absolute ethyl alcohol dissolvings of film forming agent are weighed, it is spare；
D, the solution obtained by step A, B and C is uniformly mixed, is eventually adding 0.5-1 parts of transdermal agent, 100 is settled to water
Part degree filters to get the pharmaceutical composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810567891.7A CN108542963A (en) | 2018-06-05 | 2018-06-05 | A kind of film forming pharmaceutical composition and preparation method thereof of prevention and treatment mastitis for milk cows |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810567891.7A CN108542963A (en) | 2018-06-05 | 2018-06-05 | A kind of film forming pharmaceutical composition and preparation method thereof of prevention and treatment mastitis for milk cows |
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| Publication Number | Publication Date |
|---|---|
| CN108542963A true CN108542963A (en) | 2018-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810567891.7A Pending CN108542963A (en) | 2018-06-05 | 2018-06-05 | A kind of film forming pharmaceutical composition and preparation method thereof of prevention and treatment mastitis for milk cows |
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| Country | Link |
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| CN (1) | CN108542963A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110742858A (en) * | 2019-10-30 | 2020-02-04 | 河南普华基因科技有限公司 | Houttuynia cordata gel for preventing and treating cow mastitis and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998323A (en) * | 2016-05-27 | 2016-10-12 | 青岛绿曼生物工程有限公司 | Film-forming pharmaceutical composition for preventing and treating cow mastitis as well as application and preparation method of pharmaceutical composition |
-
2018
- 2018-06-05 CN CN201810567891.7A patent/CN108542963A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998323A (en) * | 2016-05-27 | 2016-10-12 | 青岛绿曼生物工程有限公司 | Film-forming pharmaceutical composition for preventing and treating cow mastitis as well as application and preparation method of pharmaceutical composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110742858A (en) * | 2019-10-30 | 2020-02-04 | 河南普华基因科技有限公司 | Houttuynia cordata gel for preventing and treating cow mastitis and preparation method and application thereof |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180918 |
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| RJ01 | Rejection of invention patent application after publication |