CN108541948A - A kind of lithocarpus litseifolius lozenge and preparation method thereof - Google Patents
A kind of lithocarpus litseifolius lozenge and preparation method thereof Download PDFInfo
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- CN108541948A CN108541948A CN201810776309.8A CN201810776309A CN108541948A CN 108541948 A CN108541948 A CN 108541948A CN 201810776309 A CN201810776309 A CN 201810776309A CN 108541948 A CN108541948 A CN 108541948A
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- China
- Prior art keywords
- lithocarpus litseifolius
- lozenge
- lithocarpus
- powder
- litseifolius
- Prior art date
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Links
- 241001365741 Lithocarpus litseifolius Species 0.000 title claims abstract description 100
- 239000007937 lozenge Substances 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 38
- 230000001070 adhesive effect Effects 0.000 claims abstract description 15
- 239000000853 adhesive Substances 0.000 claims abstract description 14
- 239000000945 filler Substances 0.000 claims abstract description 14
- 239000000080 wetting agent Substances 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 10
- 239000011122 softwood Substances 0.000 claims abstract description 8
- 230000001954 sterilising effect Effects 0.000 claims abstract description 8
- 235000020985 whole grains Nutrition 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 235000019441 ethanol Nutrition 0.000 claims description 18
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 12
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 12
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 12
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000012141 concentrate Substances 0.000 claims description 10
- 108010011485 Aspartame Proteins 0.000 claims description 9
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 9
- 229960003438 aspartame Drugs 0.000 claims description 9
- 235000010357 aspartame Nutrition 0.000 claims description 9
- 239000000605 aspartame Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 150000001336 alkenes Chemical class 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 206010018473 Glycosuria Diseases 0.000 abstract description 3
- 208000008589 Obesity Diseases 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 3
- 235000020824 obesity Nutrition 0.000 abstract description 3
- 229920002472 Starch Polymers 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 7
- 239000003826 tablet Substances 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- -1 dihydrochalcone glucoside Chemical class 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 229920002774 Maltodextrin Polymers 0.000 description 4
- 239000005913 Maltodextrin Substances 0.000 description 4
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940035034 maltodextrin Drugs 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 3
- 241000234314 Zingiber Species 0.000 description 3
- 235000006886 Zingiber officinale Nutrition 0.000 description 3
- 235000008397 ginger Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002218 hypoglycaemic effect Effects 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241001633106 Lithocarpus Species 0.000 description 2
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 2
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 2
- IOUVKUPGCMBWBT-DARKYYSBSA-N Phloridzin Natural products O[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-DARKYYSBSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229940100243 oleanolic acid Drugs 0.000 description 2
- VGEREEWJJVICBM-UHFFFAOYSA-N phloretin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=C(O)C=C(O)C=C1O VGEREEWJJVICBM-UHFFFAOYSA-N 0.000 description 2
- IOUVKUPGCMBWBT-UHFFFAOYSA-N phloridzosid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-UHFFFAOYSA-N 0.000 description 2
- IOUVKUPGCMBWBT-QNDFHXLGSA-N phlorizin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-QNDFHXLGSA-N 0.000 description 2
- 235000019139 phlorizin Nutrition 0.000 description 2
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229940032147 starch Drugs 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- ZWTDXYUDJYDHJR-UHFFFAOYSA-N (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one Natural products OC1=CC(O)=CC=C1C=CC(=O)C1=CC=C(O)C=C1O ZWTDXYUDJYDHJR-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000004900 autophagic degradation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- QXMNTPFFZFYQAI-IMDKZJJXSA-N beta-sitosterol 3-O-beta-D-glucopyranoside Natural products CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)O[C@@H]5C[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)C QXMNTPFFZFYQAI-IMDKZJJXSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- NPJICTMALKLTFW-OFUAXYCQSA-N daucosterol Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NPJICTMALKLTFW-OFUAXYCQSA-N 0.000 description 1
- QDFKFNAHVGPRBL-UHFFFAOYSA-N daucosterol Natural products CCC(CCC(C)C1CCC2C1CCC3C2(C)CC=C4CC(CCC34C)OC5OC(CO)C(O)C(O)C5O)C(C)C QDFKFNAHVGPRBL-UHFFFAOYSA-N 0.000 description 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001599 direct drying Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 238000009702 powder compression Methods 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of lithocarpus litseifolius lozenge and preparation method thereof, the lithocarpus litseifolius lozenge includes following components according to mass fraction：Lithocarpus litseifolius powder 26.75%~27%, filler 50.5%~52.5%, adhesive 20.5%~22.5%, corrigent 0.25%.Softwood, sterilizing, thus obtaining the product after whole grain tabletting drying is prepared by the way that each component is uniformly mixed addition wetting agent.Lithocarpus litseifolius lozenge of the present invention has the characteristics that small, carrying convenience, convenient to take, is not only suitable for glycosuria patient and obesity person's use is also applied for each age level crowd.And existing market does not occur the related report of lithocarpus litseifolius lozenge, has wide development prospect.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of lithocarpus litseifolius lozenge and preparation method thereof.
Background technology
Lithocarpus litseifolius (Lithocarpus litsefolius (Hance) Chun) is Fagaceae Lithocarpus plant, is a kind of
Collect the rare species of food, tea, four kinds of sugar, medicine functions.Lithocarpus litseifolius, which is one kind that western developed country is being sought, to be had well
Healthcare function and the valuable wild resource plant for replacing carbohydrate for being suitble to obese people and diabetic population to use.In May, 2017
National health State Family Planning Commission issue a public proclamation (2017 No. 7) lithocarpus litseifolius is classified as new raw-food material.Lithocarpus litseifolius is mainly with leaf
It is used as medicine, dihydrochalcone glucoside is with the activity for inhibiting activation hyaluronidase.Also " three anti-" (it is anti-oxidant,
Antiallergy, anticancer become), the effect of " three drop " (blood pressure lowering, hypoglycemic, reducing blood lipid).Currently, the ingredient of lithocarpus litseifolius is ground in China
Study carefully and achieve great achievement, research shows that phloridzin has significant effect to diabetes control.The main component of lithocarpus litseifolius is
Phloridzin (I), phloretin (II), dihydrochalcone -2 '-β-D- glucopyranosides (III), daucosterol (IV), cupreol
(V), (Ⅸ) nine kind of Quercetin (VI), cyanidenon (VII), quercitin (VIII) and oleanolic acid compound.Lithocarpus litseifolius contains
Abundant flavonoids, anti-aging, protect liver, adjusts Vascular permeability at its verified hypoglycemic, reducing blood lipid of tool of polyphenol compound
Property, to artery sclerosis, diuresis, antibacterial anti-inflammatory, inhibit tumour cell, cell autophagy etc. promoted to have pharmacological action；Oleanolic acid
It is the active ingredient of lithocarpus litseifolius cough-relieving.
As people are to the growing interest of health and to the preference of natural health-care products and pharmaceuticals, the exploitation to lithocarpus litseifolius
There is higher researching value with application.The wooden ginger leaves are a kind of natural health-care products with a variety of good healthcare functions, are one
The new raw-food material of kind great potential.The utilization of lithocarpus litseifolius Sweet tea is mainly made with sweet-tea drink and dry tea currently on the market
Based on.Lozenge refers to the compressed tablets contained in slow mechanism dissolved in oral cavity, can to oral cavity and it is pharyngeal generate lasting drug effect, mainly pass through
Sublingual and oral cavity buccal surface mucosa absorption has absorption rapid, rapid-action, convenient to take, in good taste, and wide application of the crowd etc. is special excellent
Point.The big multipair pharynx throat of lozenge promotes the production of body fluid to quench thirst, Disperse hepatic depression, foster lung yin, dissolving phlegm addiction, clearing heat and detoxicating etc. has effect.Lithocarpus litseifolius contains
Piece has the characteristics that small, carrying convenience, convenient to take.Therefore lithocarpus litseifolius is suitable for each age level crowd, at present
Market does not occur the related report of lithocarpus litseifolius lozenge, has wide development prospect.
Invention content
The purpose of the present invention is intended to provide a kind of lithocarpus litseifolius lozenge and preparation method thereof, have small, carrying convenience,
Feature convenient to take.
The present invention is realized especially by following technical scheme：
A kind of lithocarpus litseifolius lozenge, the lithocarpus litseifolius lozenge include following components according to mass fraction：Lithocarpus litseifolius
Powder 26.75%~27%, filler 50.5%~52.5%, adhesive 20.5%~22.5%, corrigent 0.25%.
Preferably, a kind of lithocarpus litseifolius lozenge, the lithocarpus litseifolius lozenge include following components according to mass fraction：Wood
Ginger leaves Ke powder 26.75%, filler 51.5%, adhesive 21.5%, corrigent 0.25%.
The lithocarpus litseifolius powder is prepared by the following method to obtain：Lithocarpus litseifolius leaf dries pulverizing is crossed into 60 mesh sieve, is pressed
According to 1:20 solid-to-liquid ratio is impregnated for 24 hours with 70% ethyl alcohol, is carried out ultrasonic wave extraction, ethyl alcohol is recovered under reduced pressure, concentrate is through macropore tree
Fat detaches, and the concentrate of acquisition is spray-dried to obtain lithocarpus litseifolius powder.
The filler is selected from one kind of starch, maltodextrin or microcrystalline cellulose, it is preferred that the filler choosing
From microcrystalline cellulose.
The adhesive is selected from starch slurry or polyvinylpyrrolidone, it is preferred that the adhesive is selected from polyethylene
Pyrrolidones.
The corrigent is selected from Aspartame.
Another object of the present invention is to provide the preparation methods of above-mentioned lithocarpus litseifolius lozenge, specifically include following steps：
Weigh lithocarpus litseifolius powder 26.75%~27%, filler 50.5%~52.5%, adhesive 20.5% respectively according to mass fraction
~22.5% and corrigent 0.25% be uniformly mixed, wetting agent is added and is prepared softwood, sterilizing, thus obtaining the product after whole grain tabletting drying.
Further, the wetting agent is selected from distilled water or ethyl alcohol.
Further, drying 30min under the conditions of the drying condition is 60 DEG C.
Beneficial effects of the present invention are：
The present invention provides a kind of lithocarpus litseifolius lozenge and preparation method thereof, obtained lithocarpus litseifolius lozenge smooth in appearance,
Color is yellowish, have it is more lasting return it is sweet slightly sweet, it is good in taste.And microbe colony sum detection is carried out to manufactured lozenge,
Water content detection, tablet weight variation detection.Its total clump count ＜ 1000CFU/g, moisture ＜ 9%, tablet weight variation ＜ 5%, it is every
Meet《Chinese Pharmacopoeia》The requirement of version defined in 2010.Lithocarpus litseifolius lozenge has small, carrying convenience, convenient to take
Feature, is not only suitable for glycosuria patient and obesity person's use is also applied for each age level crowd.And existing market does not go out
The related report of existing lithocarpus litseifolius lozenge, has wide development prospect.
Specific implementation mode
Below in conjunction with specific embodiment of the present invention, technical solution of the present invention is clearly and completely described, is shown
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Lithocarpus litseifolius lozenge of the present invention includes following components according to mass fraction：Lithocarpus litseifolius powder 26.75%~27% is filled out
Fill agent 50.5%~52.5%, adhesive 20.5%~22.5%, corrigent 0.25%, it is preferred that include according to mass fraction
Following components：Lithocarpus litseifolius powder 26.75%, filler 51.5%, adhesive 21.5%, corrigent 0.25%.
Lithocarpus litseifolius powder of the present invention is prepared by the following method：Weigh a certain amount of lithocarpus litseifolius for smashing it through 60 mesh sieve
Powder, according to 1:20 solid-to-liquid ratio is impregnated for 24 hours with 70% ethyl alcohol.In frequency 40kHz, the time is that 30min carries out ultrasonic wave extraction.
Ethyl alcohol is recovered under reduced pressure, concentrate is detached through macroreticular resin, and the concentrate of acquisition is spray-dried to obtain lithocarpus litseifolius powder.Gained
Lithocarpus litseifolius powder oozes the unique smell of people in the faint yellow sweetness with lithocarpus litseifolius.
General lozenge is made of the effective active constituent of plant and auxiliary material, and different auxiliary materials determines the different work(of lozenge
Energy.General pharmaceutic adjuvant requires chemical property to stablize, inactive, and it is anti-that chemistry does not occur with main active components of plants
It answers, does not influence mainly to dissolve out the natural or synthetic raw material that agent measures.The reasonable employment of auxiliary material has been largely fixed lozenge
Quality assurance.
Filler is called diluent, filler, is, to increase the weight or volume of lozenge, to make more to hold for filling tablet
Easy tabletting.Common filler has starch, Icing Sugar, maltodextrin, lactose, microcrystalline cellulose etc..Because Icing Sugar and lactose contain sugar
Class, and the main function of lithocarpus litseifolius is blood pressure lowering, blood fat, blood glucose.The present invention has selected starch, maltodextrin, microcrystalline cellulose
Element.Wherein starch property stablize, hygroscopicity is small, cheap, is not chemically reacted with most drugs, but compressibility compared with
Difference；Maltodextrin has stronger viscosity, is dissolved in hot water, does not dissolve in ethyl alcohol, and improper use can make tablet surface point, water occur
Print causes disintegration of tablet or dissolution slow；Microcrystalline cellulose compressibility is preferable, and binding force is stronger, and the tablet hardness being pressed into is larger,
" dry adhesives " that can be used as direct powder compression use.Therefore preferred filler is microcrystalline cellulose.
Adhesive can make inviscid or sticky smaller solid accumulation be bonded to particle or thick liquid.Such as starch slurry, hydroxyl
Third methylcellulose, polyvinylpyrrolidone, sodium carboxymethylcellulose etc..The present invention has selected starch slurry and polyvinylpyrrolidine
Ketone, the results showed that starch slurry has good adhesive effect but is easier to lump, and is unfavorable for tabletting.Therefore preferred adhesive is polyethylene
Pyrrolidones.
Although lithocarpus litseifolius per se with sweet taste, by preliminary experiment find be not added corrigent when, contain
The bitter taste of piece, which still compares, to be difficult to receive, and mouthfeel is fresh and sweet after corrigent is added, and the taste of lithocarpus litseifolius itself will not be covered.
According to the hypoglycemic effect of lithocarpus litseifolius, select Aspartame as corrigent, Aspartame is a kind of synthesis corrigent,
Sugariness is 200 times of sucrose, oral not received by human body, and glycosuria patient and obesity person is suitble to use.
The preparation method of lithocarpus litseifolius lozenge of the present invention, specifically includes following steps：Wood is weighed respectively according to mass fraction
Ginger leaves Ke powder 26.75%~27%, microcrystalline cellulose 50.5%~52.5%, 20.5%~22.5% and of polyvinylpyrrolidone
Aspartame 0.25% is uniformly mixed, and wetting agent is added, softwood, sterilizing, thus obtaining the product after whole grain tabletting drying is prepared.
Wherein the wetting agent is selected from distilled water or ethyl alcohol.The drying condition is dry under the conditions of being 60 DEG C
30min。
Embodiment 1
The preparation of lithocarpus litseifolius powder：The a certain amount of lithocarpus litseifolius powder for smashing it through 60 mesh sieve is weighed, according to 1:20 consolidate
Liquor ratio is impregnated for 24 hours with 70% ethyl alcohol.In frequency 40kHz, the time is that 30min carries out ultrasonic wave extraction.Ethyl alcohol is recovered under reduced pressure, it is dense
Contracting liquid is detached through macroreticular resin, and the concentrate of acquisition is spray-dried to obtain lithocarpus litseifolius powder.The lithocarpus litseifolius powder of gained is in
The faint yellow sweetness with lithocarpus litseifolius is oozed the unique smell of people.
The preparation of lithocarpus litseifolius lozenge：Weigh lithocarpus litseifolius powder 26.25%, microcrystalline cellulose respectively according to mass fraction
51.5%, polyvinylpyrrolidone 22.5% and Aspartame 0.25% are uniformly mixed, and wetting agent distilled water is added and is prepared
Softwood, whole grain tabletting, the sterilizing, thus obtaining the product lithocarpus litseifolius lozenge after dry 30min under the conditions of 60 DEG C.
Embodiment 2
The preparation of lithocarpus litseifolius powder：The a certain amount of lithocarpus litseifolius powder for smashing it through 60 mesh sieve is weighed, according to 1:20 consolidate
Liquor ratio is impregnated for 24 hours with 70% ethyl alcohol.In frequency 40kHz, the time is that 30min carries out ultrasonic wave extraction.Ethyl alcohol is recovered under reduced pressure, it is dense
Contracting liquid is detached through macroreticular resin, and the concentrate of acquisition is spray-dried to obtain lithocarpus litseifolius powder.The lithocarpus litseifolius powder of gained is in
The faint yellow sweetness with lithocarpus litseifolius is oozed the unique smell of people.
The preparation of lithocarpus litseifolius lozenge：Weigh lithocarpus litseifolius powder 26.75%, microcrystalline cellulose respectively according to mass fraction
52.5%, polyvinylpyrrolidone 20.5% and Aspartame 0.25% are uniformly mixed, and wetting agent distilled water is added and is prepared
Softwood, whole grain tabletting, the sterilizing, thus obtaining the product lithocarpus litseifolius lozenge after dry 30min under the conditions of 60 DEG C.
Embodiment 3
The preparation of lithocarpus litseifolius powder：The a certain amount of lithocarpus litseifolius powder for smashing it through 60 mesh sieve is weighed, according to 1:20 consolidate
Liquor ratio is impregnated for 24 hours with 70% ethyl alcohol.In frequency 40kHz, the time is that 30min carries out ultrasonic wave extraction.Ethyl alcohol is recovered under reduced pressure, it is dense
Contracting liquid is detached through macroreticular resin, and the concentrate of acquisition is spray-dried to obtain lithocarpus litseifolius powder.The lithocarpus litseifolius powder of gained is in
The faint yellow sweetness with lithocarpus litseifolius is oozed the unique smell of people.
The preparation of lithocarpus litseifolius lozenge：Weigh lithocarpus litseifolius powder 26.75%, microcrystalline cellulose respectively according to mass fraction
51.5%, polyvinylpyrrolidone 21.5% and Aspartame 0.25% are uniformly mixed, and wetting agent distilled water is added and is prepared
Softwood, whole grain tabletting, the sterilizing, thus obtaining the product lithocarpus litseifolius lozenge after dry 30min under the conditions of 60 DEG C.
Embodiment 4
The preparation of lithocarpus litseifolius powder：The a certain amount of lithocarpus litseifolius powder for smashing it through 60 mesh sieve is weighed, according to 1:20 consolidate
Liquor ratio is impregnated for 24 hours with 70% ethyl alcohol.In frequency 40kHz, the time is that 30min carries out ultrasonic wave extraction.Ethyl alcohol is recovered under reduced pressure, it is dense
Contracting liquid is detached through macroreticular resin, and the concentrate of acquisition is spray-dried to obtain lithocarpus litseifolius powder.The lithocarpus litseifolius powder of gained is in
The faint yellow sweetness with lithocarpus litseifolius is oozed the unique smell of people.
The preparation of lithocarpus litseifolius lozenge：Weigh lithocarpus litseifolius powder 27%, microcrystalline cellulose respectively according to mass fraction
50.5%, polyvinylpyrrolidone 22.25% and Aspartame 0.25% are uniformly mixed, and wetting agent distilled water is added and is prepared
Softwood, whole grain tabletting, the sterilizing, thus obtaining the product lithocarpus litseifolius lozenge after dry 30min under the conditions of 60 DEG C.
5 lozenge microbial total fungal counting of embodiment
The detection method of microbial total bacterium number：Spread plate method.
Experimental subjects：Embodiment 3 prepares gained lozenge.
Average colony number × extension rate × 10 that total bacteria count=same dilution repeats three times.
By 10-1、10-2、10-3、10-4、10-5、10-6、10-7Three suitable gradients of middle selection, each gradient are done three parts and are put down
Row, what is selected here be extension rate is 10-3、10-4、10-5Three gradients, the results are shown in Table 1.
1 total plate count testing result of table
It is as shown in Table 1 10 in extension rate-3、10-4、10-5Bacterium colony, i.e. microbial total bacterium number ＜ are not grown
1000CFU/g.Meet《Chinese Pharmacopoeia》The requirement of version defined in 2010.
The detection of 6 lozenge moisture of embodiment
Moisture in lithocarpus litseifolius lozenge is detected using direct drying method.
The arithmetic mean of instantaneous value (X) × 100% of relative standard deviation (RSD)=standard deviation (SD)/result of calculation.
Experimental subjects：Embodiment 3 prepares gained lozenge.
It takes 3.00g to crush or levigate lithocarpus litseifolius lozenge is placed in the aluminium box dried to constant weight or flat measuring cup is set
Dry 2~4h in 100 ± 5 DEG C of thermostatic drying chamber, covers taking-up and is put into drier and be cooled to room temperature weighing, places into perseverance
Dry 1h, takes out in incubator drying box, until front and back of poor quality twice no more than 2mg, as constant weight.Calculate moisture, knot
Fruit is shown in Table 2.
2 water content detection result of table
By measuring three times, it is 7.46%, RSD=2.74% to obtain average value, shows that precision is good.Lithocarpus litseifolius contains
The moisture of piece is 7.46%, is less than 9%, meets national standard.
7 sensory evaluation of embodiment
The quality of a usual index cannot reflect the quality containing tablet quality, and many indexes is needed to consider, so logical
It is evaluation criterion to the appearance of lozenge, institutional framework, flavour, mouthfeel etc. to cross and establish an evaluation method, counts 5 people's appraisal results
It is averaged acquisition sensory evaluation, scoring is specifically shown in Table 3.
3 sensory evaluation grade form of table
Feeling evaluation is carried out respectively to the lithocarpus litseifolius lozenge prepared in Examples 1 to 4, the results are shown in Table 4.
Result is commented in 4 sensory evaluation of table
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (9)
1. a kind of lithocarpus litseifolius lozenge, which is characterized in that the lithocarpus litseifolius lozenge includes following components according to mass fraction：
Lithocarpus litseifolius powder 26.75%~27%, filler 50.5%~52.5%, adhesive 20.5%~22.5%, corrigent
0.25%.
2. a kind of lithocarpus litseifolius lozenge according to claim 1, which is characterized in that the lithocarpus litseifolius lozenge is according to matter
It includes following components to measure score：Lithocarpus litseifolius powder 26.75%, filler 51.5%, adhesive 21.5%, corrigent 0.25%.
3. a kind of lithocarpus litseifolius lozenge according to claim 1 or 2, which is characterized in that the lithocarpus litseifolius powder passes through
Following methods are prepared：Lithocarpus litseifolius leaf dries pulverizing is crossed into 60 mesh sieve, according to 1:20 solid-to-liquid ratio is soaked with 70% ethyl alcohol
Bubble for 24 hours, carries out ultrasonic wave extraction, ethyl alcohol is recovered under reduced pressure, concentrate is detached through macroreticular resin, and the concentrate of acquisition is spray-dried
Obtain lithocarpus litseifolius powder.
4. a kind of lithocarpus litseifolius lozenge according to claim 1 or 2, which is characterized in that the filler is selected from crystallite
Cellulose.
5. a kind of lithocarpus litseifolius lozenge according to claim 1 or 2, which is characterized in that the adhesive is selected from poly- second
Alkene pyrrolidone.
6. a kind of lithocarpus litseifolius lozenge according to claim 1 or 2, which is characterized in that the corrigent is selected from A Si
Ba Tian.
7. a kind of preparation method of lithocarpus litseifolius lozenge, which is characterized in that include the following steps：It is weighed respectively according to mass fraction
Lithocarpus litseifolius powder 26.75%~27%, microcrystalline cellulose 50.5%~52.5%, polyvinylpyrrolidone 20.5%~22.5%
It is uniformly mixed with Aspartame 0.25%, wetting agent is added, softwood, sterilizing, thus obtaining the product after whole grain tabletting drying is prepared.
8. preparation method according to claim 7, which is characterized in that the wetting agent is selected from distilled water or ethyl alcohol.
9. preparation method according to claim 7, which is characterized in that under the conditions of the drying condition is 60 DEG C
Dry 30min.
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